| detection of parvovirus b19 in macerated fetal tissue using in situ hybridisation. | to compare the application of a non-radioactive in situ hybridisation (ish) technique with an immunocytochemical technique for the detection of human parvovirus b19 in formalin fixed, paraffin wax embedded sections of macerated fetal tissue. | 1997 | 9389975 |
| parvovirus b19 quiescence during the course of human immunodeficiency virus infection in persons with hemophilia. | to detect and characterize parvovirus b19 infection during the course of progressive immune deficiency from human immunodeficiency virus (hiv), ten subjects enrolled in the multicenter hemophilia cohort study were followed for 6.4 to 15 years from hiv seroconversion through extreme immune deficiency. four to five sera or plasma samples from each subject, collected at predetermined cd4+ lymphocyte levels, were tested for immunoglobulin g (igg) and m (igm) b19 antibodies and dna. all 42 samples we ... | 1997 | 9395187 |
| association of parvovirus b19 genome in children with myocarditis and cardiac allograft rejection: diagnosis using the polymerase chain reaction. | inflammatory diseases of the heart, including myocarditis and cardiac transplant rejection, are important causes of morbidity and mortality in children. although viral infection may be suspected in either of these clinical conditions, the definitive etiology is often difficult to ascertain. furthermore, the histology is identical for both disorders. coxsackievirus has long been considered the most common cause of viral myocarditis; however, we previously demonstrated by polymerase chain reaction ... | 1997 | 9396454 |
| maternal serum alpha-fetoprotein and human chorionic gonadotropin in pregnant women with acute parvovirus b19 infection with and without fetal complications. | maternal serum alpha-fetoprotein (ms-afp) and human gonadotropin (ms-hcg) were retrospectively determined in 137 sera from 65 pregnant women with an acute parvovirus b19 infection. in 35 of the pregnant women, fetal complications occurred (group 1); in the remaining 30 women, there were no fetal complications (group 2). in group i, significant elevations of ms-afp were detected in 13 of the 35 women (37 per cent) and of ms-hcg in 25 of the 35 women (71 per cent). in nine of those women, sera wer ... | 1997 | 9399352 |
| low prevalence of active parvovirus b19 infection in hiv-infected patients. | in a prospective study to determine the prevalence of parvovirus b19 in adult patients positive for the human immunodeficiency virus, a series of 55 consecutively presenting patients was tested for antibodies to parvovirus b19 and parvovirus b19 dna. specific igg antibodies were detected in 96% of cases; specific igm antibodies were present in 10%. viral dna was not detected in any of the sera analysed by polymerase chain reaction. anemia could not be correlated with the presence of either igg o ... | 1997 | 9405950 |
| collaborative study to assess the suitability of a proposed working reagent for human parvovirus b19 dna detection in plasma pools by gene amplification techniques. b19 collaborative study group. | a collaborative study was done to examine the sensitivity and specificity of assays for the detection of human parvovirus b19 dna in plasma pools by pcr techniques and to establish a working reagent for b19 dna testing of plasma pools. | 1997 | 9407637 |
| a multicenter pharmacosurveillance study for the evaluation of the efficacy and safety of recombinant factor viii in the treatment of patients with hemophilia a. german kogenate study group. | in this open multicenter study the safety and efficacy of recombinant factor viii (rfviii) was assessed in 39 previously treated patients with hemophilia a (factor viii basal activity < or = 15%). recombinant fviii was administered for prophylaxis and treatment of bleeding episodes and for surgical procedures. a total of 3679 infusions of rfviii were given. efficacy of rfviii as assessed by subjective evaluation of response to infusion and mean annual consumption of rfviii was comparable to that ... | 1997 | 9408018 |
| [acute pericarditis caused by human parvovirus b-19]. | | 1997 | 9410062 |
| [transient erythroblastopenia in children. severe anemia with good prognosis]. | transient erythroblastopenia of childhood (tec) is an acute form of anaemia characterized by a transient red blood cell aplasia, of unknown cause, in the bone marrow. the incidence appears to be increasing. 16 patients were seen in our paediatric department during the period 1990 to 1996. the ages varied from two to 48 months. all patients had severe anaemia, the lowest mean haemoglobin values being 4.9 (2.2-7.8) g/100 ml. the reticulocyte count was low in 14 patients, whereas two patients had r ... | 1997 | 9411857 |
| cutaneous vasculitis due to human parvovirus b19 in an hiv-infected patient: report of a case. | | 1997 | 9412714 |
| diagnosis and clinical course of autoimmune neutropenia in infancy: analysis of 240 cases. | primary autoimmune neutropenia (ain) is caused by granulocyte-specific autoantibodies and occurs predominantly in infancy. clinical presentation and diagnosis have not been well established, resulting in burdening diagnostic investigations and unnecessary treatment with granulocyte colony-stimulating factor (g-csf). in the present study, clinical, laboratory, and immunologic data of 240 infants with primary ain were evaluated. suspected association with parvovirus b19 infection was investigated ... | 1998 | 9414283 |
| characterization of cis-acting and ns1 protein-responsive elements in the p6 promoter of parvovirus b19. | parvovirus b19 infections are associated with diverse clinical manifestations, ranging from no symptoms to severe symptoms. the virus shows an extreme tropism for replication in erythroid progenitor cells, possibly due to the activity of the only functional promoter (p6) of the b19 virus genome in combination with both cell- and cell cycle-specific factors and the trans-activator protein ns1. as presented here, p6 promoter sequences derived from several b19 virus isolates proved to be highly con ... | 1998 | 9420265 |
| parvovirus b19 infection-related complications in renal transplant recipients: treatment with intravenous immunoglobulin. | chronic red cell aplasia can develop in immunocompromised patients including transplant recipients infected with parvovirus b19 (pv b19). renal involvement with pv b19 infection is not well-recognized. | 1997 | 9422430 |
| [cryoglobulinemia and parvovirus b19 infection]. | | 1997 | 9424130 |
| parvovirus particles in a fetal-heart with myocarditis: ultrastructural and immunohistochemical study. | we report on the occurrence of parvovirus particles and vp1 (84 kda) and vp2 (58 kda) viral antigens in the heart of a case of fatal myocarditis in a fetus of a 26 year old women. numerous cells containing intranuclear inclusions were identified within the blood vessels of the heart in a close apposition to muscle fibers. these cells were characterized by plentiful mitochondria and were consistent with erythroblasts. typically, inclusions consisted of electrondense marginated chromatin and granu ... | 1997 | 9437504 |
| parvovirus b19 infection in hong kong. | human parvovirus b19 is a small dna virus that can cause a number of diseases, notably erythema infectiosum in children, and aplastic crisis in patients with chronic haemolytic disorders. with the availability of serological tests for parvovirus infection, much is known about the prevalence of this virus in the western population. however, there have not been any data on the epidemiological pattern of parvovirus b19 infection in hong kong and its surrounding region. in this report we have studie ... | 1997 | 9459396 |
| parvovirus-induced pancytopenia in a child with acquired haemolytic anaemia. | a 14-year-old boy, with acquired haemolytic anaemia secondary to paravalvular leak from a prosthetic aortic valve, presented with severe pancytopenia. subsequent investigation showed serological evidence of recent parvovirus b19 infection. the patient required transfusion and subsequently improved rapidly, with maintenance of pre-infective haemoglobin levels. to our knowledge this is the first reported case in which infection with parvovirus has caused pancytopenia in an acquired chronic mechani ... | 1997 | 9460570 |
| [the diagnostic value of anti-cmv and anti-hpv-b19 antiviral antibodies in studies on causes of recurrent abortions]. | presence of serum anti-cytomegalovirus (cmv) and anti-parvovirus b19 (hpv-b19) antibodies was studied in 11 women within the first day after consecutive spontaneous abortion in the second trimester of pregnancy and in the control group, consisting of 15 women in the second trimester of a normal pregnancy. most of studied women manifested presence of serum igg class anti-cmv antibodies (igg-anti-cmv) and levels of the antibodies proved significantly higher in women following spontaneous abortions ... | 1997 | 9463082 |
| long-term outcome of children following maternal human parvovirus b19 infection. | to determine the long-term outcomes of children exposed in utero to maternal parvovirus b19 infection. | 1998 | 9464735 |
| [comment on contribution by t. glück, r. h. straub, j. schölmerich, b. lang: "infections and vasculitis"]. | | 1997 | 9465384 |
| lupus syndrome after parvovirus b19 infection. | systemic lupus erythematosus is uncommon in elderly individuals. a 72-year-old woman developed parvovirus b19 infection followed by a systemic lupus erythematosus-like syndrome with persistent thrombocytopenia and raynanud's phenomenon. few cases of systemic lupus erythematosus after parvovirus b19 infection have been reported, and none had thrombocytopenia. | 1997 | 9476277 |
| evaluation of parvo b19, cmv and hpv viruses in human aborted material using the polymerase chain reaction technique. | to investigate the role of human parvovirus b19 (parvo b19), cytomegalovirus (cmv) and human papilloma virus (hpv) viruses in the aetiopathogenesis of spontaneous abortions. | 1998 | 9481569 |
| human parvovirus b19 dna detected by receptor-mediated hemagglutination assay of pooled plasma for fractionation. | | 1998 | 9482405 |
| prospective evaluation of 618 pregnant women exposed to parvovirus b19: risks and symptoms. | to assess the risk of maternal parvovirus b19 infection from exposure to various sources and the fetal morbidity of those infections. | 1998 | 9491870 |
| a clinical and epidemiological study of human parvovirus b19 infection in fetal hydrops using pcr southern blot hybridization and chemiluminescence detection. | ninety-eight samples from 80 cases of spontaneous abortions after fetal death or hydrops fetalis from 12,000 pregnant women were examined using pcr. dna was extracted from amniotic fluid, fetal blood, ascitic fluid and fetal biopsies or placenta specimens using qia amp kits (qiagen). a 270-bp length fragment located within the b19 gene ns1 was amplified using pcr followed by electrophoresis and southern-blot hybridization assay using a horseradish peroxidase-labelled probe and chemiluminescence ... | 1998 | 9496373 |
| petechial gloves and socks syndrome caused by parvovirus b19. | this report describes a 14-year-old boy with petechial gloves and socks syndrome associated with acute parvovirus b19 infection. this represents only the second child reported with this distinctive exanthem. | 1998 | 9496801 |
| testing for parvovirus b19 in henoch-schönlein syndrome? | | 1998 | 9496814 |
| immediate and long term outcome of human parvovirus b19 infection in pregnancy. | to estimate more precisely the risk of fetal loss and congenital abnormalities after maternal parvovirus b19 infection, and to assess the long term outcome for surviving infants. | 1998 | 9501782 |
| life-threatening parvovirus b19-associated myocarditis and cardiac transplantation as possible therapy: two case reports. | parvovirus b19 infection can cause a wide spectrum of disease syndromes. two cases of parvovirus b19 infection were identified that resulted in life-threatening myocarditis shortly after acute infection in immunocompetent individuals. the diagnosis was made with serological and polymerase chain reaction techniques. one patient was successfully treated by heart transplantation. sequence analysis showed that the parvovirus b19 cloned from the patients' sera had 99% homology with the prototype sequ ... | 1998 | 9502455 |
| [ascites with "activated" lymphocytes in a case of hydrops fetalis related to a parvovirus b19 infection]. | a case of non immunologic hydrops fetalis associated with parvovirus b19 infection is reported. viral etiology was suspected by the pattern of overstimulated lymphocytes in fetal ascites and confirmed later by identification of parvovirus b19 by pcr. the cytologic finding center helps the precocious diagnosis. | 1997 | 9509326 |
| antenatal parvovirus infection: clinical implications. | | 1998 | 9509501 |
| hepatitis-associated aplastic anemia and acute parvovirus b19 infection: a report of two cases and a review of the literature. | hepatitis-associated aplastic anemia is rare in general, but occurs in up to 28% of patients receiving liver transplantation for fulminant non-a, non-b hepatitis. cases are commonly young men with mild hepatitis but severe aplastic anemia. although cases have been reported in association with hepatitis a, b, and c, most appear to be due to a non-a-b-c virus. we report two cases of acute hepatitis subsequently complicated by marrow hypoplasia in patients with acute parvovirus b19 infection. hepat ... | 1998 | 9517662 |
| persistence of parvovirus b19 dna in testis of patients with testicular germ cell tumours. | germ cell tumours (gct) of the testis are the most common malignant tumours occurring in young adults. in view of the young age of patients, the increasing incidence of gct and the overexpression of wild-type p53 observed in a majority of tumours, the possibility of the involvement of a virus in the development of this cancer was considered. testicular gct were analysed for the presence of cytomegalovirus and epstein-barr virus (ebv), which are known to cause overexpression of wild-type p53 prot ... | 1998 | 9519836 |
| prevalence of parvovirus b19 infection among patients with human immunodeficiency virus infection in barcelona, spain. | | 1998 | 9521236 |
| [parvovirus b19--a cause of hepatitis in patients with liver transplantation, anemia in hiv positive individuals and encephalopathies in children]. | | 1998 | 9522660 |
| human parvovirus b19 nonstructural (ns1) protein induces apoptosis in erythroid lineage cells. | infection of erythroid-lineage cells by human parvovirus b19 is characterized by a gradual cytocidal effect. accumulating evidence now implicates the nonstructural (ns1) protein of the virus in cytotoxicity, but the mechanism underlying the ns1-induced cell death is not known. using a stringent regulatory system, we demonstrate that ns1 cytotoxicity is closely related to apoptosis, as evidenced by cell morphology, genomic dna fragmentation, and cell cycle analysis with the human erythroleukemia ... | 1998 | 9525624 |
| regulation of human b19 parvovirus promoter expression by hgabp (e4tf1) transcription factor. | the genetic expression of human b19 parvovirus is only dependent on one promoter in vivo and in vitro. this is the p6 promoter, which is located on the left side of the genome and is a single-stranded dna molecule. this led us to investigate the regulation of the p6 promoter and the possible resulting variability of the nucleotide sequence. after analysis of the promoter region of 17 b19 strains, only 1.5% variability was found. more exciting was the finding of mutations that were clustered arou ... | 1998 | 9525935 |
| [the blood-born viral infections]. | recently it has become urgent to establish a risk control system against emerging and re-emerging infectious diseases. many of the emerging and re-emerging infectious diseases such as aids and viral hepatitis, are induced by viral infection via blood. the main causative agents of blood-born viral infection are hepatitis b virus (hbv), hepatitis c virus (hcv), human immunodeficiency virus (hiv), human t cell leukemia virus type1 (htlv1), cytomegalovirus (cmv), epstein-barr virus (ebv), and human ... | 1998 | 9528333 |
| raised igm antibodies to parvovirus b19 in juvenile rheumatoid arthritis. | to delineate the role of human parvovirus b19 in the etiopathogenesis of juvenile rheumatoid arthritis (jra), igm and igg antibodies specific for parvovirus b19 surface protein antigen(s) were estimated in the sera using commercial elisa kits. sera of 69 jra patients (median age 16 yr, male : female ratio 1.1:1) satisfying the criteria of american rheumatism association along with 26 sera of rheumatoid arthritis (ra) and 12 sera of healthy children as disease and normal controls respectively wer ... | 1998 | 9529776 |
| [current developments in the laboratory diagnosis of rubella]. | thirty years after the introduction of the hemagglutination inhibition assay (hai), laboratory diagnosis of rubella virus infection has achieved a high reliability. while the hai remains the reference standard against which newer assays are compared, routine laboratory diagnosis is based mainly on elisa tests which permit a more rapid and less cumbersome detection of specific igg and igm antibody. although quantification of immunoglobulin g against rubella virus is performed using who standards, ... | 1997 | 9534272 |
| chronic parvovirus b19 infection induces the production of anti-virus antibodies with autoantigen binding properties. | human parvovirus b19 infection in adults shows some clinical features similar to those found in autoimmune connective tissue diseases. to better clarify the relationship between viral infection and autoimmunity, we have evaluated the ability of anti-parvovirus antibodies to specifically recognize autoantigens in ten patients with chronic symmetric arthritis resembling rheumatoid arthritis or with recurrent episodes of arthritis and cutaneous manifestations and persistence of specific igm antibod ... | 1998 | 9541589 |
| [seroprevalence of anti-human parvovirus b19 antibodies in a sample of blood donors in galicia]. | to determine the seroprevalence of antibodies to human parvovirus b19 (pvb19) in a series of 92 blood donors in galicia. | 1998 | 9542305 |
| human parvovirus b19 infections in infants and children. | | 1997 | 9544309 |
| parvovirus b19 infection and unresponsiveness to erythropoietin therapy in haemodialysis patients. | | 1998 | 9550669 |
| transport of viruses through fetal membranes: an in vitro model of perinatal transmission. | a model system for perinatal transmission of viral infections was developed and transport of infectious virus particles through fetal membranes was investigated. viruses of different families known to cause serious intrauterine infections were selected, including relevant and model viruses: the dna-viruses hsv-1 and -2 as well as the animal herpes viruses bhv-1 and shv-1, the rna-virus bvdv as a model for hepatitis c virus, hiv-1 and -2, and ppv as a model for parvovirus b19. migration of infect ... | 1998 | 9557298 |
| comparative evaluation of three recombinant antigen-based enzyme immunoassays for detection of igm and igg antibodies to human parvovirus b19. | diagnosis of acute and past infection with parvovirus b19 is based on detection of igm and igg antibodies. | 1998 | 9562859 |
| detection of intrauterine viral infection using the polymerase chain reaction. | intrauterine viral infection commonly presents as nonimmune hydrops fetalis or intrauterine growth restriction. cytomegalovirus (cmv) and parvovirus are commonly recognized causes of fetal infection using serology and cultures. we used the polymerase chain reaction (pcr) to evaluate the frequency of fetal viral infection and the associated clinical course and outcome. specimens (amniotic fluid, fetal blood, pleural fluid, tissue) from 303 abnormal pregnancies at risk for viral infection and 154 ... | 1998 | 9562961 |
| rising incidence of parvovirus b19 infection. | | 1998 | 9563206 |
| high cost, low volume care in haemophilia. | | 1998 | 9564014 |
| photo quiz ii. leukocytoclastic vasculitis secondary to parvovirus b19 infection. | | 1998 | 9564461 |
| still's disease, severe thrombocytopenia, and acute hepatitis associated with acute parvovirus b19 infection. | | 1998 | 9564490 |
| detection of parvovirus b19 infection in first and second trimester fetal loss. | fetal and placental tissues and maternal sera from a series of 273 cases of first and second trimester fetal loss were collected to detect the frequency of parvovirus b19 infection. in addition, fetal tissues were studied for the presence of congenital anomalies. serology of maternal sera, histology of fetal tissues and placenta, polymerase chain reaction (pcr), in situ hybridization (ish), and immunohistochemistry (ihc) were used for the detection of parvovirus b19 infection. sera were tested f ... | 1998 | 9566279 |
| exanthems in childhood: an update. | | 1998 | 9568622 |
| successful treatment of gangrene in systemic necrotizing vasculitis with iloprost. | systemic necrotizing vasculitis is uncommon in children and may be rarely associated with gangrene. we describe a 3-yr-old girl with parvovirus b19-induced necrotizing vasculitis whose digital gangrene was successfully treated with iloprost, a prostacyclin analogue. | 1998 | 9569082 |
| nucleic acid immunization protects dogs against challenge with virulent canine parvovirus. | nucleic acid vaccines (navs) use expression vectors encoding one or more antigen genes to transfect host cells inducing both humoral and cellular immunity against the expressed antigen. nav offers major advantages over conventional vaccines for the protection of humans and animals. this study shows that a plasmid dna (pgt36vp1) encoding the full length vp1 region of canine parvovirus (cpv) induces immunity that protects dogs against challenge with virulent virus. five dogs without anti-cpv antib ... | 1998 | 9569471 |
| gestational parvovirus infection in united arab emirates. | | 1998 | 9570674 |
| autoantibodies and common viral illnesses. | to review the literature about common autoantibodies produced in association with viral infection. | 1998 | 9572708 |
| recombinant human parvovirus b19 vectors: erythroid cell-specific delivery and expression of transduced genes. | a novel packaging strategy combining the salient features of two human parvoviruses, namely the pathogenic parvovirus b19 and the nonpathogenic adeno-associated virus type 2 (aav), was developed to achieve erythroid cell-specific delivery as well as expression of the transduced gene. the development of such a chimeric vector system was accomplished by packaging heterologous dna sequences cloned within the inverted terminal repeats of aav and subsequently packaging the dna inside the capsid struc ... | 1998 | 9573295 |
| persistent parvovirus b19 infections in immunocompromised children. | immunocompromised patients have been shown to suffer from prolonged viral infections often without detectable immune response. here chronic infections with low virus levels can be frequently observed. in these patients viral dna can be detected over long periods by polymerase chain reaction (pcr). in this study parvovirus b19 presence was assessed by pcr, immunoblot and enzyme-linked immunosorbent assay in sera from children with mainly oncological and hematological diseases. in 45% of sera b19 ... | 1998 | 9574901 |
| [parvovirus b19 as infectious agent in infants]. | since its casual discovery and implication as a human pathogen that provokes transitory aplastic crises and infectious erythema, the b19 parvovirus has been related to a wide spectrum of diseases. to better understand this clinical diversity, we reviewed the cases of a serology positive infants admitted to the hospital. | 1997 | 9575116 |
| pure red cell aplasia due to persistent b19 parvovirus infection in patient infected with human immunodeficiency virus type 1. recovery with alpha-interferon therapy. | b19 parvovirus (pv) infection is ordinarily resolved with the production of specific antibodies that neutralize virus infectivity for erythroid host cells. nevertheless persistent infection with b19 pv and pure red blood cell aplasia have been documented. a 27 year-old male. i.v. drug abuser, hiv+ and hcv was diagnosed of pure red cell aplasia. six months later we had serologic evidence of persistent parvovirus infection. interferon therapy, started for hcv infection, showed a marked improvement ... | 1998 | 9577184 |
| neonatal erythema infectiosum. | a report is presented of a patient with neonatal erythema infectiosum who developed petechiae, transient thrombocytopenia and transient cardiac failure due to transplacental transmission of human parvovirus b19 (hpv b19) infection. it is suggested that the thrombocytopenia was caused by platelet-associated igg produced by the patient, and that the cardiac failure may have been caused by direct entry of hpv b19 into the cardiac tissue. | 1998 | 9583210 |
| small bowel atresia: antenatal intestinal vascular accident or parvovirus b19 infection? | | 1998 | 9589151 |
| case management study: polyarthritis with fever. | in most cases, a thorough initial evaluation will reveal the cause of fever and polyarthritis. however, in some patients the initial diagnosis may be unclear and, as time passes, the characteristic clinical patterns emerge. recurrent attacks are suggestive of other conditions such as crystal-induced arthritis, lyme disease, and mediterranean fever. in rheumatoid arthritis and reiter's syndrome, the fever resolves and the articular findings predominate with the passage of time. similarly, still's ... | 1998 | 9595837 |
| parvovirus: a review. | infections caused by human parvovirus b19 result in a variety of clinical manifestations, the severity of which depends on the immune and hematologic status of the host. arthropathy is known to occur in children and adults with acute parvovirus b19 infection. in adults, the arthropathy is common and is usually brief and self-limited, although a chronic arthropathy due to hpv b19 infections can occur rarely. it is important to differentiate between such chronic infection and ra, because of the si ... | 1998 | 9595838 |
| [human parvovirus b19 infection in perinatal transmission and abnormal fetuses]. | to investigate the perinatal infection of human parvovirus b19 in pregnant women and their fetuses. | 1997 | 9596898 |
| b19 parvovirus induced fetal hydrops: rapid and simple diagnosis by detection of b19 antigens in amniotic fluids. | in our study we describe the direct detection of parvovirus b19 capsid antigens in amniotic fluid samples for the rapid and simple prenatal diagnosis of b19 induced fetal hydrops. the assay was performed on amniotic fluid specimens from fetal hydrops dotted on nylon membranes. the two capsid antigens, vp1 and vp2, which represent four per cent and 96 per cent of the capsid, respectively, were detected using a pool of monoclonal antibodies directed against these two proteins and the complex was v ... | 1998 | 9602483 |
| fetal parvovirus b19 infection and meconium peritonitis. | a 33-year-old primigravida at 26 weeks gestation presented with fetal hydrops and fetal anemia following prior parvovirus b19 infection. the fetus required two intrauterine transfusions of packed red cells. at 35 weeks gestation, a cesarean section was performed for obstetric reasons. as a consequence of a prenatal bowel perforation, the neonate developed meconium peritonitis, for which she needed laparotomy. this case demonstrates that there may be an association between intrauterine parvovirus ... | 1998 | 9605610 |
| rheumatic manifestations of parvovirus b19 infection. | human parvovirus b19 is an emerging dna virus. b19 infection is common and widespread. major manifestations of b19 infection are transient aplastic crisis, erythema infectiosum, hydrops fetalis, acute and chronic rheumatoid-like arthropathy, and, in the immunocompromised host, chronic or recurrent bone marrow suppression. a number of less common manifestations of b19 infection include various rash illnesses, neuropathies, and acute fulminant liver failure. of rheumatologic interest, b19 infectio ... | 1998 | 9606764 |
| factors impeding efficient expression of factor viii complementary dna minigenes. | haemophilia a is a bleeding disorder that affects approximately 1 in 10,000 males. it is caused by a deficiency of functional blood-clotting factor viii. protein-replacement therapy has been effective as treatment, resulting in a vast improvement in the quality of life and dramatically increasing the life expectancy of patients. however, therapy with plasma-derived factor viii has allowed the transmission of several human viruses, such as hepatitis viruses, human immunodeficiency virus and parvo ... | 1997 | 9607109 |
| nondiagnostic bone marrow in parvovirus b19-related anemia in aids: confounding effect of prior transfusion? | | 1998 | 9607872 |
| papular acrodermatitis of childhood related to poxvirus and parvovirus b19 infection. | papular acrodermatitis of childhood (gianotti-crosti syndrome) is considered an unspecific cutaneous pattern related to an increasing number of infectious diseases. we report two cases of gianotti-crosti syndrome, one of which occurred in the setting of parvovirus b19 primary infection and the other followed poxvirus infection. parvovirus b19 and poxvirus may represent new causative agents of gianotti-crosti syndrome. | 1998 | 9608338 |
| variable presentation of parvovirus b19 in a family. | this case report of the sequential presentation of parvovirus b19 in a family describes a 38-year-old woman initially presenting with 'gloves and socks' syndrome, along with her husband and five children who were also affected. a high clinical attack rate with prolonged illness and variable clinical presentations was demonstrated, including polyarthritis, erythema infectiosum and symptoms of a respiratory tract infection. in addition, the range of syndromes and clinical features of parvovirus b1 ... | 1998 | 9611383 |
| spontaneous recovery from severe parvovirus b19 pure red cell aplasia, in a heart transplant recipient, as demonstrated by marrow culture. | a 61-year-old heart transplant recipient with parvovirus b19 infection, presented as a severe pure red cell aplasia (prca) with hemoglobin level of 5 g/dl. both blood and bone marrow cells were positive for parvovirus b19 dna, whereas specific immunoglobulins igg and igm were not informative. bone marrow smears revealed erythroid hypoplasia without giant pronormoblasts. autologous and allogenic bone-marrow cultures revealed a high inhibition by patient's serum on bfu-e growth whereas the number ... | 1998 | 9615250 |
| typing of european strains of parvovirus b19 by restriction endonuclease analyses and sequencing: identification of evolutionary lineages and evidence of recombination of markers from different lineages. | european isolates of parvovirus b19 were analyzed by restriction enzyme analysis of pcr products of the vp1/2 coding region and sequencing of the same amplified region, five cloned fragments from each pcr product. two main groupings were found based on three perfectly linked point deviations. on the assumption that identical point deviations causing the various restriction patterns regardless of time and origin of virus isolation were unlikely to emerge independently in different evolutionary li ... | 1998 | 9620213 |
| novel cytomorphology of the giant proerythroblasts of parvovirus b19 infection. | the morphology of the giant proerythroblasts (gpe) in air-dried and wright-giemsa-stained smears of bone marrow in 16 patients with pure red cell aplasia (prca) caused by parvovirus b19 infection is described. b19 infection was diagnosed by the presence of the virus or viral dna and/or igm antibodies. twelve patients had chronic hemolytic anemia and aplastic crisis and 4 patients had aids with chronic prca. in patients with chronic hemolytic anemia and aplastic crisis, gpe were not detectable in ... | 1998 | 9625574 |
| increase of platelet-associated igg (pa-igg) and hemophagocytosis of neutrophils and platelets in parvovirus b19 infection. | | 1998 | 9631589 |
| [ulcers of the tongue, pityriasis lichenoides and primary parvovirus b19 infection]. | we report a case of parapsoriasis en gouttes (or pityriasis lichenoides) which presents two peculiarities. first, the patient had lingual ulcerations and second, the eruption appeared during a seroconversion for parvovirus b19. | 1996 | 9636752 |
| [hereditary spherocytosis associated with severe hypophosphatemia in patients recovering from aplastic crisis]. | this is a report about two cases of hereditary spherocytosis complicated by severe hypophosphatemia, while recovering from aplastic crisis. case #1: a 31-year-old male, who had jaundice and splenomegaly since the age of 15 and who has a son diagnosed with hemolytic anemia, was admitted because of fever lymphadenopathy, and jaundice. a diagnosis of hereditary spherocytosis was made based on microspherocytes observed in his peripheral blood smear. after admission, the anemia became more serious fo ... | 1998 | 9637890 |
| [relationship between human parvovirus b19 infection and spontaneous abortion]. | to determine whether there is a relationship between parvovirus b19 infection and spontaneous abortion. | 1997 | 9639755 |
| [pregnancies complicated by human b19 parvovirus infection: prevention and treatment]. | | 1997 | 9639758 |
| [diagnosis of human parvovirus b19 infection in nonimmune hydrops fetalis]. | parvovirus b19 (pv b19) infection was investigated in 29 pregnant women with fetal hydrops, after exclusion of feto-maternal incompatibility within red blood cell antigens, torch infections, feto-maternal hemorrhage and genetics reasons. the active viral infection was detected in 9 women (31%) by pcr amplification of dna b19; in 2 of them igm and igg, in 1 igm and in 4 igg antibodies were also present. in 6 women (20%) igg antibodies were only found, but not igm and dna b19, which confirmed infe ... | 1998 | 9640861 |
| [human parvovirus b19-induced aplastic crisis in a case with spherocytosis]. | a 43-year-old female with spherocytosis was admitted to the hospital because of fever, headache, and rapidly progressive anemia. on admission, she had severe anemia (hb 3.9 g/dl) with marked decrease in reticulocytes (0.3%). some premature leukocytes, such as promyerocyte, were observed in the peripheral blood. bone marrow smear revealed normocellular marrow with normal presence of erythroid cells. anti-human parvovirus b19 igm and igg antibody was positive in the serum on admission. the dna of ... | 1998 | 9642948 |
| acute parvovirus b19 infection in pregnant women--an analysis of serial samples by serological and semi-quantitative pcr techniques. | the serological and virological course of parvovirus b19 infection was followed in 14 women who suffered symptomatic or subclinical acute infection during pregnancy. serial serum samples from the patients were tested for igg and igm antibodies and the levels of parvovirus b19 dna were monitored using a semi-quantitative pcr assay. in addition, the outcome of the pregnancies was documented by clinical information and by testing cord blood for parvovirus b19 specific antibodies as well as for parv ... | 1998 | 9646103 |
| [seroprevalence versus parvovirus b19 in blood donors]. | the aim of the study was to describe the seroprevalence against parvovirus b19 in a random sample of blood donors in the hospital universitario de salamanca. | 1998 | 9646558 |
| human parvovirus b19 as a causative agent for rheumatoid arthritis. | human parvovirus b19 (b19) dna was detected in the synovial tissues in 30 of 39 patients with rheumatoid arthritis (ra), and infrequently in those with osteoarthritis and traumatic joints. on the other hand, the expression of the b19 antigen vp-1 was specific (27/27) in ra synovium with active synovial lesions, but not in osteoarthritis and controls. the target cells of b19 were macrophages, follicular dendritic cells, t cells, and b cells, but not synovial lining cells in the synovium. b19-nega ... | 1998 | 9653169 |
| serologic and virologic evidence for frequent intrauterine transmission of human parvovirus b19 with a primary maternal infection during pregnancy. | to define the intrauterine viral transmission rate during primary maternal parvovirus b19 infection and identify factors that may influence this rate. | 1998 | 9655540 |
| detection of parvovirus b19 in macerated fetal tissue using in situ hybridization. | | 1998 | 9659278 |
| a case of guillain-barré syndrome associated with human parvovirus b19 infection. | we report a 4-year-old boy who presented with guillain-barré syndrome 11 days after the onset of erythema infectiosum. the illness resolved without gamma globulin therapy. | 1998 | 9661947 |
| immunogold probes in electron microscopy. | | 1998 | 9664388 |
| intra-uterine parvovirus b19 infection and meconium peritonitis. | b19 fetal infection has been associated with hydrops or fetal death. we report four cases of meconium peritonitis in hydropic fetuses with laboratory diagnosis of b19 infection. parvovirus b19 dna was detected by in situ hybridization both in cord blood and in amniotic cells in three fetuses, while in one case only cord blood was available and proved positive. signs of active or recent b19 infection in maternal serum samples were documented only in two cases, which proved positive for specific i ... | 1998 | 9664606 |
| frequency of parvovirus b19 infection in nonimmune hydrops fetalis and utility of three diagnostic methods. | the rate of parvovirus b19 (pv) infection in cases of "idiopathic" nonimmune hydrops fetalis (nihf) is reported to be approximately 16% with polymerase chain reaction (pcr)-based methods. antibodies for use in paraffin-embedded tissue have not been systematically compared with pcr or with the presence of inclusions at varying gestational ages. all autopsy cases of nihf and those with effusions of multiple serous membranes examined between 1991 and 1996 (n = 29) were evaluated for the presence of ... | 1998 | 9670826 |
| papular-purpuric gloves and socks syndrome associated with acute parvovirus b19 infection: case report and review. | the papular-purpuric gloves and socks syndrome (ppgss) was first described in 1990. this syndrome is characterized by fever, acral pruritus, edema, petechiae, and oral erosions. subsequently, parvovirus b19 has been implicated, in most cases, as the causative agent of this syndrome. to date, with two exceptions, all published cases of ppgss have been from europe and the middle east and have been mainly reported in the dermatology literature. herein, we report what we believe to be only the secon ... | 1998 | 9675471 |
| [parvovirus b19 infection--a meningococcus-like sepsis]. | two otherwise healthy adults with fever and haemorrhagic exanthema are described. in both, primary human parvovirus infection was diagnosed. the clinical picture of fever and haemorrhagic exanthema should always arouse suspicion of serious disease such as meningococcal infection. if the patient is unaffected, however, primary human parvovirus infection should be borne in mind. | 1998 | 9679439 |
| persistent b19 parvovirus infection in pediatric malignancies. | the frequency and clinical importance of parvovirus b19 infection were studied in children investigated or treated for various malignancies and cytopenias. | 1998 | 9680929 |
| [virological diagnosis of an outbreak of fever and rashes caused by parvovirus b19, cuba, 1995]. | the results obtained in the study of an a outbreak of fever and rash occurred in havana city in march, 1995, are reported. dengue, measles, rubella, herpes simplex, and epstein barr were discarded as causal agents of the outbreak in the samples of 35 patients. parvovirus b19 was identified as the causing agent of the outbreak by the detection of igm antibodies and the polymerase chain reaction technique (pcr). the infection produced by this agent was confirmed in 14/18 samples (77.7%) by some of ... | 1997 | 9685954 |
| [parvovirus b19 atypical acrosyndrome]. | parvovirus b19 infection is a very polymorphic eruption. we describe a new clinical form. | 1997 | 9686060 |
| [parvovirus b19 primo-infection and cold agglutinins]. | parvovirus b19 infection is frequent. primary infection leads to diverse skin manifestations including the recently described gloves-and-socks papulopurpura. | 1997 | 9686061 |
| high prevalence of parvovirus b19 igg antibodies among dutch hemophilia patients. | human parvovirus b19 is a potential risk to hemophiliac patients receiving blood products. | 1998 | 9691402 |
| human parvovirus b19 antibodies are less frequent among patients treated with factor ix concentrate inactivated by ultrafiltration: a report from a single spanish institution. | | 1998 | 9691409 |