| the seroprevalence of igg antibodies to human papillomavirus (hpv) types hpv-16, hpv-18, and hpv-11 capsid-antigens in mothers and their children. | human papillomavirus (hpv) types causing anogenital lesions and cancer are accepted as being sexually transmitted. the methods whereby children acquire these anogenital type hpv infections are unclear. the present study determined the prevalence of anti-hpv-16, hpv-11 and hpv-18 igg antibodies in mothers and their children in an attempt to identify evidence of hpv transmission from mother to child. hpv virus-like particles (vlp) vlp-16, vlp-11 and vlp-18 were used in enzyme-linked immunosorbent ... | 2007 | 17607783 |
| expression of the hpv11 e2 gene in transgenic mice does not result in alterations of the phenotypic pattern. | the e2 early protein of human papillomaviruses (hpv) has been found associated with the mitotic spindle therefore being implicated in the partition of the replicated viral dna to daughter cells. in addition, e2 proteins bind to the upstream regulatory region of the virus and to cellular promoters modulating thereby cellular transcription and differentiation. in many cervical cancers, the e2 reading frame is interrupted upon incorporation of the viral genome into the host dna. this results in the ... | 2008 | 17701441 |
| do g protein-coupled receptors expressed in human lingual epithelium interact with hpv11? | human papillomaviruses infect epithelia but little is known about the nature of cell surface receptors interacting with the viral particles. it has been proposed that glycosaminoglycans and integrins may be involved in the attachment process. in the present study, the putative interactions of virus-like particles of human papillomavirus type 11 (hpv11), which present a tropism for nasopharyngeal epithelia, with olfactory and taste receptors expressed in the human lingual epithelium were studied. ... | 2007 | 17705193 |
| human papilloma virus type and recurrence rate after surgical clearance of anal condylomata acuminata. | anal condylomata acuminata (aca) are caused by human papilloma virus (hpv) infection which is transmitted by close physical and sexual contact. the result of surgical treatment of aca has an overall success rate of 71% to 93%, with a recurrence rate between 4% and 29%. the aim of this study was to assess a possible association between hpv type and aca recurrence after surgical treatment. | 2009 | 19543141 |
| transitional cell neoplasm of the nasolacrimal duct associated with human papillomavirus type 11. | tumors of the lacrimal sac are rare but noteworthy because of their significant potential to become malignant or life-threatening if treatment is delayed. dermatologists may be the first to encounter such neoplasms. | 2010 | 19615034 |
| anal condyloma acuminatum. | anal condyloma acuminatum is a human papillomavirus (hpv) that affects the mucosa and skin of the anorectum and genitalia. anal condyloma acuminatum is the most commonly diagnosed sexually transmitted disease in the united states. to date, there are more than 100 hpv types, with hpv-6, hpv-10, and hpv-11 predominately found in the anogenital region and causing approximately 90% of genital warts. risk factors for anal condyloma acuminatum include multiple sex partners, early coital age, anal inte ... | 2009 | 19820442 |
| differential binding patterns to host cells associated with particles of several human alphapapillomavirus types. | the focus of this research was to compare the binding profiles of human papillomavirus (hpv) 11, 16, 18 and 45 virus-like particles (vlps) to hacat cells and to the extracellular matrix (ecm) secreted by these cells. all four hpv types tested bind to a component(s) of the ecm. hpv11 vlp binding is blocked when the ecm is pretreated with an anti-laminin 5 (ln5) polyclonal antibody. a series of treatments utilizing heparins and heparinase revealed that hpv18 vlps are dependent on heparan sulfates ... | 2010 | 19846678 |
| rna interference silences the human papillomavirus 6b/11 early gene e7 in vitro and in vivo. | rna interference (rnai) is a potential therapeutic tool in the treatment of various diseases, such as cancers and viral infections. silencing of e7 genes is an effective method to suppress human papilloma virus (hpv)-related tumours. | 2010 | 19874368 |
| inducible heat shock protein 70 enhances hpv31 viral genome replication and virion production during the differentiation-dependent life cycle in human keratinocytes. | increasing data indicate heat shock proteins (hsps) including inducible hsp70 (hsp70i) are involved in the replicative cycles of various viruses including adenoviruses (ads), polyomaviruses (pyvs), and some rna viruses. cell-free system studies implicate hsp70i in human papillomavirus type 11 (hpv11) genome replication with e1 and e2 proteins, and there is evidence that hsp70 is involved in capsid assembly and disassembly for pyvs and hpvs. hsp70 expression is increased in hpv16 e6/e7 gene trans ... | 2010 | 19896513 |
| malignant transformation of a highly aggressive human papillomavirus type 11-associated recurrent respiratory papillomatosis. | the objective is to present an uncommon case of squamous cell carcinoma (scc) arising from extensive recurrent respiratory papillomatosis (rrp) involving the upper and lower airway and temporal bone. | 2010 | 20015762 |
| characterization of human papillomavirus type 11-specific immune responses in a preclinical model. | human papillomavirus (hpv) types 6 and 11 are associated with recurrent respiratory papillomatosis (rrp). although a prophylactic vaccine has been developed that protects against hpv infection, a therapeutic vaccine is still needed for those patients infected with and/or suffering from persistent disease. therefore, we developed a novel, therapeutic dna vaccine targeting hpv-11 and characterized the in vivo immunologic responses generated against hpv-11 e6 and e7 after dna vaccination in a precl ... | 2010 | 20025042 |
| [construction and immunogenicity evaluation of chimerical dna vaccine of human papillomavirus type 11]. | to construct chimerical dna vaccine plasmid of human papillomavirus type 11 (hpv11) l1-e7, and to evaluate its immunogenicity. | 2009 | 20104772 |
| [expression, purification and immunogenicity of human papillomavirus type 11 virus-like particles from escherichia coli]. | to produce human papillomavirus type 11 virus-like particles (hpv11 vlps) from escherichia coli and to investigate its immunogenicity and type cross neutralization nature. | 2009 | 20112683 |
| novel human papilloma virus (hpv) genotypes in children with recurrent respiratory papillomatosis. | recurrent respiratory papillomatosis (rrp) is characterized by the presence of benign virally induced tumors of the larynx and respiratory epithelium that may obstruct the airway and tend to recur frequently. rrp is caused by the human papilloma virus (hpv), most frequently by hpv types 6 and 11. in this study, we present four cases of children with rrp in whom hpvs other than hpv-6 or hpv-11 were found. | 2010 | 20213305 |
| conjunctival papilloma caused by human papillomavirus type 11 treated with systemic interferon in a five-year-old boy. | conjunctival papilloma is a benign tumor of the conjunctival mucosa. in childhood, papilloma represents 7-10% of conjunctival tumors. human papillomavirus (hpv)-6 and hpv-11 are the major hpv types responsible for conjunctival lesions. a five-year-old boy with a two-year history of conjunctival papilloma caused by hpv type 11 treated with systemic interferon alpha is reported and the literature is reviewed. | 2010 | 20402076 |
| betulin and ursolic acid synthetic derivatives as inhibitors of papilloma virus. | the synthesis of new betulin and ursolic acid derivatives and evaluation of their antiviral activity in vitro is reported. betulin was modified at positions c-3, c-20 and c-28 to afford the derivatives with nicotinoyl-, methoxycynnamoyl-, alkyne and aminopropoxy-2-cyanoethyl-moieties. the two stage conversion of betulin to the new ursane-type triterpenoid by treatment of allobetulin with ac(2)o-hclo(4) is suggested. cyanoethylation of ursonic acid oxime led to cyanoethyloximinoderivative. accord ... | 2010 | 20558062 |
| human papillomavirus e2 protein with single activation domain initiates hpv18 genome replication, but is not sufficient for long-term maintenance of virus genome. | the papillomavirus life cycle is regulated by a family of proteins encoded by the e2 open reading frame; e2 proteins regulate viral gene expression, dna replication and genome maintenance. we have previously shown that the bovine papillomavirus (bpv1) full-length e2 protein forms heterodimers with repressor forms of e2, and these e2 heterodimers serve as activators of transcription and replication during the viral life cycle. in the present study, using the single-chain e2 heterodimer as a model ... | 2010 | 20940072 |
| [vaccine against human papilloma virus]. | genital human papilloma virus infection (hpv) is the most common sexually transmitted infection worldwide, it is the cause of genital warts, and it is related with cervical cancer, the second most common cause of death from cancer in women in america, and the first in underdeveloped countries, and it is related with penis and prostate cancer in males also, and with anal cancer in both genders. this review examines the most important actual facts about hpv infection, and the new prophylactic vacc ... | 2008 | 19263667 |
| diseases caused by human papillomaviruses (hpv). | human papillomaviruses (hpv) are non-enveloped tumor viruses with a double stranded dna approximately 8 kilobases in length. the viral genome is enclosed by a spherical capsid with icosahedral symmetry and a diameter of about 55 nm. more than 100 hpv types have been identified. they infect the squamous epithelia of skin and mucosa and usually cause benign papillomas or warts. persistent infection with high-risk oncogenic hpv causes all cervical cancers, most anal cancers, and a subset of vulvar, ... | 2009 | 19302229 |
| population attributable fraction of infection-related cancers in korea. | a number of infectious agents have been classified as human carcinogens. the purpose of the current study was to provide an evidence-based assessment of the burden of infection-related cancers in the korean population. materials and methods: the population attributable fraction was calculated using infection prevalence data from 1990 or earlier, relative risk estimates from meta-analyses using mainly korean studies and national data on cancer incidence and mortality for the year 2007. | 2011 | 20974652 |
| human papillomavirus and epstein barr virus in oral hairy leukoplakia among hiv positive venezuelan patients. | oral hairy leukoplakia (ohl) is commonly found in individuals infected with hiv and represents the most frequent oral manifestation. the purpose of this study was to detect the presence of human papillomavirus (hpv) and epstein barr virus (ebv) in ohl of hiv+ venezuelan patients. we evaluated 21 hiv+ adult patients with clinically present ohl lesions: 11 under antiretroviral therapy, 10 without therapy, and 10 oral mucosal samples as controls. nested-pcr was used to detect ebv and hpv infection. ... | 2010 | 21053684 |
| differential expression of cellular micrornas in hpv-11 transfected cells. an analysis by three different array platforms and qrt-pcr. | human papillomavirus type 11 (hpv-11) infects the genital and the respiratory tract leading to condylomas and respiratory papillomatosis. hpv infections are restricted to epithelial tissue and the progression through the virus lifecycle is tightly coordinated to the differentiation of the host cell. the changes of cellular micrornas by hpv-11 gene expression were investigated in a cell culture model of hacat cells transfected with hpv-11, with the goal of understanding which cellular processes w ... | 2010 | 21078297 |
| [synthesis of triterpenoid acylates - an effective reproduction inhibitors of influenza a (h1n1) and papilloma viruses]. | the synthesis of a new group of triterpenoid acylates on the basis of oleanolic, glycyrrhetic and ursolic acids and betulin is described. in studying the activity of the synthesized compounds in relation to reproduction of virus pathogens of respiratory infections 28-o-methoxycynnamoylbetulin shows high activity against influenza type a (h1n1) the selectivity index si > 100. the high activity of 3,28-dinicotinoylbetulin against papilloma virus (strain hpv-11) was detected, the selectivity index ... | 2010 | 21317951 |
| human papillomavirus (hpv) 6, 11, 16, and 18 seroprevalence is associated with sexual practice and age: results from the multinational hpv infection in men study (him study). | few human papillomavirus (hpv) serology studies have evaluated type-specific seroprevalence of vaccine hpv types in men. this study investigates seroprevalence of hpv 6, 11, 16, and 18, and associated risk factors in men residing in three countries (united states, mexico, and brazil). | 2011 | 21378268 |
| detection of high-risk human papillomavirus types 16 and 18 but not 33 and 52 in external genital warts from iranian females. | background: external genital warts (egw) are relatively common sexually transmitted diseases. in the majority of cases, low-risk human papilomaviruses (hpv), such as hpv-6 and hpv-11, are responsible but, high-risk types may also be detected and this has a bearing on vaccines for cervical cancer prevention. in this study the incidence of the high-risk hpv types 16, 18, 33 and 52 in egws of females from the southwest of iran was assessed. methods: seventy-nine women with egws participated in this ... | 2011 | 21627381 |
| anal hpv genotypes and related displasic lesions in italian and foreign born high-risk males. | anal intraepithelial neoplasia and anal cancer are closely related to infection from high-risk human papilloma virus (hpv) genotypes. since hpvs involved in disease progression are reported to vary by geographical regions, this study focuses on hpv genotypes spectrum in 289 males attending a sexual transmitted diseases (std) unit according to their nationality. anal cytology, digene hybrid capture assay (hc2) and hpv genotyping were evaluated in 226 italian (it) and 63 foreign born (fb) subjects ... | 2009 | 19480957 |
| virological failure of intralesional cidofovir therapy in recurrent respiratory papillomatosis is not associated with genetic or epigenetic changes of hpv11: complete genome comparison of sequential isolates. | five sequential human papillomavirus type 11 (hpv11) positive samples collected from an aggressive juvenile onset recurrent respiratory papillomatosis before, during and after intralesional cidofovir therapy leading to virological failure after initial response were analyzed. sequencing of the complete genome as well as methylation analysis by bisulfate modification and sequencing of the long control region (lcr) were performed to seek for genetic and epigenetic changes as a possible background ... | 2011 | 21945249 |
| incidence of low risk human papillomavirus in oral cancer: a real time pcr study on 278 patients. | squamous cell carcinoma is the most frequent malignant tumour of the oral cavity. it is widely known that tobacco and alcohol consumption are the major causes of the development of oral squamous cell carcinoma (oscc). the human papilloma virus infection has also been postulated as a risk factor for squamous cell carcinoma, although conflicting results have been reported. the aim of this study is to evaluate the presence of high-risk and low-risk type human papillomavirus in a large sample of squ ... | 2011 | 21781451 |
| the role of human papilloma virus (hpv) genotyping in recurrent respiratory papillomatosis in rasoul akram hospital. | the most common laryngeal mass in children is recurrent respiratory papillomatosis (rrp). studies have attempted to correlate viral typing and its aggressiveness. | 2012 | 23483670 |
| assessment of human papilloma virus infection in adult laryngeal papilloma using a screening test. | human papilloma virus (hpv) infection is involved in both juvenile and adult laryngeal papilloma. we wished to determine which types of adult laryngeal papilloma were clinically related to hpv infection. we hypothesized that multiple-site and recurrent papillomas would have a strong relationship to hpv and conducted the present study to test this hypothesis. | 2012 | 23273988 |
| human papillomavirus and other genital infections in indigenous women from paraguay: a cross-sectional analytical study. | the incidence of cervical cancer in paraguay is among the highest in the world, with the human papillomavirus (hpv) being a necessary factor for cervical cancer. knowledge about hpv infection among indigenous women is limited. this cross-sectional study analyzed the frequency of hpv and other genital infections in indigenous paraguayan women of the department of presidente hayes. | 2013 | 24206645 |
| no evidence for cross-protection of the hpv-16/18 vaccine against hpv-6/11 positivity in female sti clinic visitors. | data from a vaccine trial and from post-vaccine surveillance in the united kingdom have suggested that the bivalent hpv-16/18 vaccine offers cross-protection against hpv-6/11 and protection against anogenital warts (agw). we studied the effect of the bivalent vaccine on genital hpv-6/11 positivity and agw in the netherlands. | 2017 | 28126492 |
| multiple human papillomavirus infection is associated with high-risk infection in male genital warts in ulsan, korea. | further understanding of male human papillomavirus (hpv) infection is necessary to prevent infection in men, as well as transmission to women. in our current study, we investigated patterns of hpv infection and genotype distributions in male genital warts using the anyplex ii hpv28 detection kit. we reviewed the medical records of 80 male patients who presented to 5 neighborhood clinics in ulsan, korea, for the treatment of genital warts between april 2014 and january 2015. all patients underwen ... | 2016 | 26955236 |
| electrocautery resection, shaving with a scalpel, and podophyllin: a combination therapy for giant condyloma acuminatum. | giant condyloma acuminatum (also known as buschke-löwenstein tumor) is a rare disease, for which the treatment of choice is still controversial. in the case described in this report, we used a combination of electrocautery and a surgical scalpel to resect a huge genital wart, followed by long-term local treatment with podophyllin. this procedure was relatively fast, easy to perform, involved minimal bleeding, and did not result in any complications. moreover, combination therapy enabled us to av ... | 2015 | 25927062 |
| clinical course of recurrent respiratory papillomatosis: comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11. | recurrent respiratory papillomatosis (rrp) is mainly associated with human papillomavirus (hpv)6 or hpv11. the purpose of this study was to compare clinical outcome, aggressiveness, and treatment response between hpv6- and hpv11-associated rrp. | 2015 | 24955561 |
| nuclear domain 10-associated proteins recognize and segregate intranuclear dna/protein complexes to negate gene expression. | dna viruses, such as herpes simplex virus type 1 (hsv-1), simian virus 40 (sv40), and cytomegaloviruses (cmv), start their replicative processes and transcription at specific nuclear domains known as nd10 (nuclear domain 10, also called pml bodies). it has been previously determined that for hsv-1 and sv40, a short dna sequence and its binding protein are required and sufficient for cell localization of viral dna replication and gene transcription. | 2012 | 23021128 |
| requirement for the e1 helicase c-terminal domain in papillomavirus dna replication in vivo. | the papillomavirus (pv) e1 helicase contains a conserved c-terminal domain (ctd), located next to its atp-binding site, whose function in vivo is still poorly understood. the ctd is comprised of an alpha helix followed by an acidic region (ar) and a c-terminal extension termed the c-tail. recent biochemical studies on bovine papillomavirus 1 (bpv1) e1 showed that the ar and c-tail regulate the oligomerization of the protein into a double hexamer at the origin. in this study, we assessed the impo ... | 2016 | 26739052 |
| [expression and polyclonal antibody preparation of hpv-11e7 protein]. | to express human papillomavirus type 11, e7 protein (hpv11e7) via a prokaryotic expression vector and produce anti-hpv11e7 polyclonal antibody. | 2014 | 24909284 |
| occurrence of vaccine and non-vaccine human papillomavirus types in adolescent finnish females 4 years post-vaccination. | control of human papillomavirus (hpv)-related cancers by inclusion of hpv vaccination into national vaccination programmes is likely. one open question is replacement of the vaccine types with other high-risk (hr) hpv types in the vaccination era. we studied occurrence of hpv types in adolescent females participating in a population-based vaccination trial. a total of 4,808 16- to 17-year-old females from finland were enrolled in the 1:1 randomized phase iii (patricia) trial of the efficacy of v ... | 2012 | 22492244 |
| seroprevalence and seroincidence of herpes simplex virus (2006-2010), syphilis (2006-2010), and vaccine-preventable human papillomavirus subtypes (2000-2010) among us military personnel. | sexually transmitted infections have historically been burdensome in military populations. we describe the seroprevalence and seroincidence of vaccine-preventable human papillomavirus (vp-hpv) subtypes in a sample of 200 servicemen, along with the seroprevalence and seroincidence of herpes simplex virus (hsv-1/2) and syphilis in a sample of 200 men and 200 women. | 2015 | 25868137 |
| human papilloma virus detection by innolipa hpv in prostate tissue from men of northeast mexico | background: prostatic adenocarcinoma by prosate cancer (pca) is the most prevalent cancer and the second cause of cancer-related death among men in the western world. human papilloma virus (hpv) may be considered as a preventable risk factor. in this study, we assessed the frequencies of hpv infection in prostatic adenocarcinoma and benign prostatic hyperplasia (bph) cases in northeast mexico. materials and methods: a total of 87 paraffin-embedded blocks (from 25 and 62 patients with definite di ... | 2016 | 28030912 |
| tracheal papillomatosis: what do we know so far? | tracheal papillomatosis (tp) is a benign condition characterized by papillomatous growth of the bronchial epithelium that involves the trachea. this abnormal growth is a result of infection with human papilloma virus (hpv). two subtypes of hpv were found in most cases of tp, hpv-6 and hpv-11. tp, presents in two forms, the juvenile onset (jo) or adult onset (ao). the clinical presentation is typically nonspecific and it ranges from mild symptoms like cough to life-threatening conditions like upp ... | 2011 | 21971565 |
| Identification and analysis of papillomavirus e2 protein binding sites in the human genome. | Papillomavirus E2 protein is required for the replication and maintenance of viral genomes and transcriptional regulation of viral genes. E2 functions through sequence-specific binding to 12-bp DNA motifs-E2 binding sites (E2BS)-in the virus genome. Papillomaviruses are able to establish persistent infection in their host and have developed a long-term relationship with the host cell in order to guarantee the propagation of the virus. In this study, we have analyzed the occurrence and functional ... | 2012 | 22031941 |
| global genomic diversity of human papillomavirus 11 based on 433 isolates and 78 complete genome sequences. | human papillomavirus 11 (hpv11) is an etiological agent of anogenital warts and laryngeal papillomas and is included in the 4-valent and 9-valent prophylactic hpv vaccines. we established the largest collection of globally circulating hpv11 isolates to date and examined the genomic diversity of 433 isolates and 78 complete genomes (cgs) from six continents. the genomic variation within the 2,800-bp e5a-e5b-l1-upstream regulatory region was initially studied in 181/207 (87.4%) hpv11 isolates coll ... | 2016 | 27030261 |
| serological assays for the detection of hpv antibodies. | a variety of serological assays to detect antibodies to genital-type hpvs have been developed. bacterially expressed fusion proteins, synthetic peptides and hpv 11 virus propagated in a xenograft system have been the most commonly used antigen targets in either western blot assays or elisas. hpv antibodies have been readily detected and most studies suggest that they are type-specific. primarily, antibodies appear to be directed against the capsid antigens. the presence or titre of antibodies to ... | 1992 | 1330907 |
| sexually transmitted papillomaviral infection in the male: ii. the urethral reservoir. | urethral cytobrushing for hybridization studies was obtained from the anterior urethra of 75 male consorts of known hpv-infected female partners. our findings revealed a 24 per cent (19 patients) incidence of positive hybridization, identifying hpv-16 or hpv-18 in six instances associated with mixed papillomaviral infection of the shaft and the presence of hpv-6 and hpv-11 in 7 cases clinically related to exophytic disease of the shaft. although no histologic evidence of virus-tissue interaction ... | 1988 | 2838945 |
| [virus papillomas and malignant genital tumors]. | morphological and epidemiological studies point to a close correlation between viral genital warts and genital cancer. benign condylomata acuminata are commonly induced by hpv-6 and hpv-11. in precancerous bowenoid genital lesions, hpv-16 and hpv-18 could be cloned directly from cervical cancer tissue. whereas the occurrence of hpv-6 and hpv-11 seems to be a low risk infection, hpv-16 and hpv-18 may represent a high risk for malignant conversion. | 1985 | 3006372 |
| synthesis and antiviral activity of maleopimaric and quinopimaric acids' derivatives. | a series of maleopimaric and quinopimaric acids' derivatives modified in the e-ring, at the carbonyl- and carboxyl-groups were synthesized and evaluated for their activity in vitro against respiratory viruses (influenza; rhinovirus; adenovirus; and sars), papilloma virus, and hepatitis b and c viruses. the antiviral screening of levopimaric acid diene adducts derivatives was carried out with minimal effect on sars and influenza type b viruses. excellent antiviral activity of the ozonolysis produ ... | 2015 | 26372075 |
| use of reprogrammed cells to identify therapy for respiratory papillomatosis. | a patient with a 20-year history of recurrent respiratory papillomatosis had progressive, bilateral tumor invasion of the lung parenchyma. we used conditional reprogramming to generate cell cultures from the patient's normal and tumorous lung tissue. analysis revealed that the laryngeal tumor cells contained a wild-type 7.9-kb human papillomavirus virus type 11 (hpv-11) genome, whereas the pulmonary tumor cells contained a 10.4-kb genome. the increased size of the latter viral genome was due to ... | 2012 | 23013073 |
| the natural history of genital human papillomavirus among hiv-negative men having sex with men and men having sex with women. | although human immunodeficiency virus (hiv)-negative men having sex with men (msm) bear a substantial burden of human papillomavirus (hpv)-associated disease, prospective studies of genital hpv infection in this population are scarce. | 2015 | 25649172 |
| seroprevalence of hpv vaccine types 6, 11, 16 and 18 in hiv-infected and uninfected women from brazil. | information on vaccine-type hpv seroprevalence is essential for vaccine strategies; however, limited data are available on past exposure to hpv-quadrivalent vaccine types in hiv-infected woman in brazil. | 2013 | 23490398 |
| synthesis and antiviral evaluation of octadecyloxyethyl benzyl 9-[(2-phosphonomethoxy)ethyl]guanine (ode-bn-pmeg), a potent inhibitor of transient hpv dna amplification. | human papillomavirus (hpv) high-risk genotypes such as hpv-16 and hpv-18 cause the majority of anogenital tract carcinomas, including cervical cancer, the second most common malignancy in women worldwide. currently there are no approved antiviral agents that reduce or eliminate hpv and reverse virus-associated pathology. we synthesized and evaluated several alkoxyalkyl acyclic nucleoside phosphonate diesters and identified octadecyloxyethyl benzyl 9-[(2-phosphonomethoxy)ethyl]guanine (ode-bn-pme ... | 2016 | 27933957 |
| papillary urothelial carcinoma with squamous differentiation in association with human papilloma virus: case report and literature review. | the human papilloma virus (hpv) is a carcinogen known for its strong association with cervical cancers and cervical lesions. it is also known to be associated with a variety of squamous cell carcinomas in other areas, such as the penis, vulva, anus and head and neck. however, the association with urothelial carcinoma remains controversial. here, we report a case of urothelial carcinoma with squamous differentiation associated with hpv-6/hpv-11. | 2016 | 27069958 |
| immunogenicity and safety of quadrivalent human papillomavirus types 6/11/16/18 recombinant vaccine in chronic kidney disease stage iv, v and vd. | up to >80% of sexually active adults will become infected with human papillomavirus (hpv) during their lifetime. persistent hpv infection can result in cervical, vulvovaginal, penile and anogenital cancer. clinical studies have shown the efficacy of three doses of quadrivalent hpv-6/11/16/18 l1 virus-like particle (vlp) vaccination, at day 0, month 2 and month 6, to lower the occurrence of hpv infection and its complications. however, immunogenicity and safety of the hpv vaccine have not been pr ... | 2017 | 26932687 |
| lack of evidence for a relationship between high risk human papillomaviruses and breast cancer in iranian patients. | whether there is any relationship between human papilloma virus (hpv) and breast carcinoma is not clear. some previous studies have indicated a possible role in oncogenesis in the breast. in this study, we therefore analyzed the presence of hpv infection in breast tissues of iranian women from yazd city. | 2016 | 27797244 |
| quality of life of young patients with recurrent respiratory papillomatosis. | to assess quality of life of children and teenagers with recurrent respiratory papillomatosis, according to the evidence of infection by human papillomavirus types 6 and 11, compared with healthy volunteers and patients with chronic otitis media. | 2017 | 28193306 |
| high-risk and low-risk human papilloma virus in association to spontaneous preterm labor: a case-control study in a tertiary center, egypt. | this study aimed to detect the correlation between human papillomavirus (hpv) and spontaneous preterm labor in egyptian women and its association to the human papilloma viral load and mpp2 gene expression. | 2017 | 28264621 |
| nucleotide and phylogenetic analysis of human papillomavirus type 11 isolated from juvenile-onset recurrent respiratory papillomatosis in china. | to assess the association between sequence variants of human papillomavirus (hpv) 11 and recurrent respiratory papillomatosis and the taxonomy and evolutionary history of hpv 11. complete hpv 11 nucleotide sequences were sequenced by illumina hiseq2000 analyzers and compared with the hpv 11 prototype isolate (genbank accession number: m14119) using blast 2.0 server software. eighteen full-length hpv 11 genomic sequences were amplified and sequenced. a total of 49 nucleotide mutations were identi ... | 2016 | 26369639 |
| an unusual, giant and benign condyloma acuminatum lesion on the genital area for more than a decade. | condyloma acuminatum, is a rare sexually transmitted disease. the virus responsible for condyloma is human papillomavirus.hpv-6 and hpv-11 are the most commonly detected hpv genotypes, but at least 20 other hpv genotypes have occasionally been found in genital wart tissue specimens. in fact genital hpv infection is common among sexually active populations. this disease may occur at any age after puberty and always seen in the mucosal area. it is characterized by slow growth. we reported here a c ... | 2014 | 25405121 |
| human papilloma virus infection in non-cancerous versus normal esophageal tissue samples by endoscopy. | cancers are the second most common cause of non-accidental deaths in iran, after cardiovascular mortality. although most cases of esophageal squamous cell carcinoma (escc) in the usa and western populations have been attributed to high levels of exposure to tobacco and alcohol, but in iranian populations, other risk factors especially infectious agents have been postulated as possible causes, particularly human papillomavirus (hpv). this study aimed to determine the prevalence and the types of h ... | 2015 | 26221490 |
| prevalence of human papilloma virus among women with breast cancer since 2005-2009 in isfahan. | human papilloma virus (hpv) dna has been detected in breast carcinoma by different laboratorial techniques, suggesting that the virus could play a role in the pathogenesis of this tumor. | 2014 | 24627883 |
| melting profiles may affect detection of residual hpv l1 gene dna fragments in gardasil®. | gardasil® is a quadrivalent human papillomavirus (hpv) protein-based vaccine containing genotype-specific l1 capsid proteins of hpv-16, hpv-18, hpv-6 and hpv-11 in the form of virus-like-particles (vlps) as the active ingredient. the vlps are produced by a dna recombinant technology. it is uncertain if the residual hpv l1 gene dna fragments in the vaccine products are considered contaminants or excipients of the gardasil® vaccine. because naked viral dna fragments, if present in the vaccine, may ... | 2014 | 24083601 |
| human papillomavirus and its influence on head and neck cancer predisposition. | human papillomavirus (hpv) is a virus often infecting humans. it is often present on skin or mucous membranes. these diverse dna viruses are often linked to many various benign and malignant neoplastic lesions. over 40 types of hpv are transmitted through sexual contact and infect the anogenital region which might be secondly transmitted to the oral mucous. over 150 hpv viruses are defined according to the invaded site. oral papillomas are marked with numbers 6, 7, 11, 16 and 32. squamous cell p ... | 2013 | 24018424 |
| lung squamous cell carcinoma arising in a patient with adult-onset recurrent respiratory papillomatosis. | a 75-year-old male was admitted to our hospital in december 2011 with a mass in the right upper pulmonary lobe. he was incidentally diagnosed as having tracheal papillomas 10 years ago. bronchoscopy revealed multiple polypoid papillomas in the dorsal lesion of the trachea. polymerase chain reaction amplification detected human papillomavirus type 11 dna in the papilloma tissues. a computed tomography scan demonstrated the occlusion of the right superior segment bronchus with distal consolidation ... | 2013 | 23110763 |
| role of the association of high-risk hpv identified by real-time pcr in cervical preneoplastic lesions. | to evaluate the effects of infection in multiple types of high-risk human papilloma virus (hpv) in cervical preneoplastic lesions in patients undergoing colposcopy following a diagnosis of atypical squamous cells of unknown significance (ascus) and low-grade squamous intraepithelial (lsil) cytology. | 2012 | 23185789 |
| anal and perianal squamous carcinomas and high-grade intraepithelial lesions exclusively associated with "low-risk" hpv genotypes 6 and 11. | anal squamous cell carcinomas are predominantly associated with high-risk human papillomaviruses (hpvs), particularly hpv 16, similar to cervical, vaginal and vulvar cancers. although the presence of "low-risk" hpvs, in particular genotypes 6 and 11, have occasionally been reported in various hpv-related anogenital cancers, the overall distribution of these genotypes in the anal canal and perianal tissue may differ to that in the cervix. in addition, although the majority of anal and perianal ca ... | 2013 | 23616200 |
| detection of human papillomavirus genotypes and major brca mutations in familial breast cancer. | breast cancer is a multistep disease and infection with a dna virus could play a role in one or more of the steps in this pathogenic process. high-risk human papillomaviruses (hpvs) are the causative agents of several cancers. in this study, we investigated hpv genotypes associated with breast cancer and its relationship with brca mutation for the detection of familial breast cancer. we analyzed 84 formalin-fixed, paraffin-embedded tissue blocks from 38 familial breast cancer and 46 nonfamilial ... | 2016 | 27186947 |
| a case of esophageal squamous cell carcinoma with positive hpv 11. | hpv (human pappiloma virus) infection is an etiologic risk factor for esophageal carcinoma with several studies supporting its carcinogenic role. the main strains are hpv16 and 18 and the less frequent strains 11, 6, 31 and 36. we report the case of a 58 year old male, smoker, admitted to our hospital for progressive dysphagia. previous endoscopies and biopsies were compatible with a hyperkeratotic esophagus, negative for dysplasia. second endoscopy showed a hyperkeratotic, verrucous, esophagus ... | 2013 | 23195756 |
| risk factors of the vertical transmission of human papilloma virus in newborns from singleton pregnancy - preliminary report. | the aim of this study was to analyze the relationship between the frequency of human papilloma virus (hpv) isolation in pregnant women and their offspring, and to assess the risk of maternal-neonatal transmission. | 2014 | 23697795 |
| genomic differences in the background of different severity in juvenile-onset respiratory papillomatoses associated with human papillomavirus type 11. | this study aimed to compare complete genome sequences of human papillomavirus (hpv) type 11 from two solitary papillomas (considered minimally aggressive), two moderately (six and nine episodes) and two highly aggressive (30 and 33 episodes) juvenile-onset respiratory papillomatoses. genomic regions were sequenced using the sanger method; sequences were compared to available genbank genomes. activity of the long control region (lcr) was assessed in hep-2 cell line using luciferase assays and com ... | 2013 | 23649705 |
| seroprevalence of human papillomavirus types 6, 11, 16 and 18 in chinese women. | human papillomavirus (hpv) seroprevalence data have not previously been reported for different geographical regions of china. this study investigated the cross-sectional seroprevalence of antibodies to hpv 6, 11, 16, and 18 virus-like particles in chinese women. | 2012 | 22715915 |