Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| no evidence for cross-protection of the hpv-16/18 vaccine against hpv-6/11 positivity in female sti clinic visitors. | data from a vaccine trial and from post-vaccine surveillance in the united kingdom have suggested that the bivalent hpv-16/18 vaccine offers cross-protection against hpv-6/11 and protection against anogenital warts (agw). we studied the effect of the bivalent vaccine on genital hpv-6/11 positivity and agw in the netherlands. | 2017 | 28126492 |
| quality of life of young patients with recurrent respiratory papillomatosis. | to assess quality of life of children and teenagers with recurrent respiratory papillomatosis, according to the evidence of infection by human papillomavirus types 6 and 11, compared with healthy volunteers and patients with chronic otitis media. | 2017 | 28193306 |
| high-risk and low-risk human papilloma virus in association to spontaneous preterm labor: a case-control study in a tertiary center, egypt. | this study aimed to detect the correlation between human papillomavirus (hpv) and spontaneous preterm labor in egyptian women and its association to the human papilloma viral load and mpp2 gene expression. | 2017 | 28264621 |
| immunogenicity and safety of quadrivalent human papillomavirus types 6/11/16/18 recombinant vaccine in chronic kidney disease stage iv, v and vd. | up to >80% of sexually active adults will become infected with human papillomavirus (hpv) during their lifetime. persistent hpv infection can result in cervical, vulvovaginal, penile and anogenital cancer. clinical studies have shown the efficacy of three doses of quadrivalent hpv-6/11/16/18 l1 virus-like particle (vlp) vaccination, at day 0, month 2 and month 6, to lower the occurrence of hpv infection and its complications. however, immunogenicity and safety of the hpv vaccine have not been pr ... | 2017 | 26932687 |
| lack of evidence for a relationship between high risk human papillomaviruses and breast cancer in iranian patients. | whether there is any relationship between human papilloma virus (hpv) and breast carcinoma is not clear. some previous studies have indicated a possible role in oncogenesis in the breast. in this study, we therefore analyzed the presence of hpv infection in breast tissues of iranian women from yazd city. | 2016 | 27797244 |
| nucleotide and phylogenetic analysis of human papillomavirus type 11 isolated from juvenile-onset recurrent respiratory papillomatosis in china. | to assess the association between sequence variants of human papillomavirus (hpv) 11 and recurrent respiratory papillomatosis and the taxonomy and evolutionary history of hpv 11. complete hpv 11 nucleotide sequences were sequenced by illumina hiseq2000 analyzers and compared with the hpv 11 prototype isolate (genbank accession number: m14119) using blast 2.0 server software. eighteen full-length hpv 11 genomic sequences were amplified and sequenced. a total of 49 nucleotide mutations were identi ... | 2016 | 26369639 |
| synthesis and antiviral evaluation of octadecyloxyethyl benzyl 9-[(2-phosphonomethoxy)ethyl]guanine (ode-bn-pmeg), a potent inhibitor of transient hpv dna amplification. | human papillomavirus (hpv) high-risk genotypes such as hpv-16 and hpv-18 cause the majority of anogenital tract carcinomas, including cervical cancer, the second most common malignancy in women worldwide. currently there are no approved antiviral agents that reduce or eliminate hpv and reverse virus-associated pathology. we synthesized and evaluated several alkoxyalkyl acyclic nucleoside phosphonate diesters and identified octadecyloxyethyl benzyl 9-[(2-phosphonomethoxy)ethyl]guanine (ode-bn-pme ... | 2016 | 27933957 |
| multiple human papillomavirus infection is associated with high-risk infection in male genital warts in ulsan, korea. | further understanding of male human papillomavirus (hpv) infection is necessary to prevent infection in men, as well as transmission to women. in our current study, we investigated patterns of hpv infection and genotype distributions in male genital warts using the anyplex ii hpv28 detection kit. we reviewed the medical records of 80 male patients who presented to 5 neighborhood clinics in ulsan, korea, for the treatment of genital warts between april 2014 and january 2015. all patients underwen ... | 2016 | 26955236 |
| human papilloma virus detection by innolipa hpv in prostate tissue from men of northeast mexico | background: prostatic adenocarcinoma by prosate cancer (pca) is the most prevalent cancer and the second cause of cancer-related death among men in the western world. human papilloma virus (hpv) may be considered as a preventable risk factor. in this study, we assessed the frequencies of hpv infection in prostatic adenocarcinoma and benign prostatic hyperplasia (bph) cases in northeast mexico. materials and methods: a total of 87 paraffin-embedded blocks (from 25 and 62 patients with definite di ... | 2016 | 28030912 |
| detection of human papillomavirus genotypes and major brca mutations in familial breast cancer. | breast cancer is a multistep disease and infection with a dna virus could play a role in one or more of the steps in this pathogenic process. high-risk human papillomaviruses (hpvs) are the causative agents of several cancers. in this study, we investigated hpv genotypes associated with breast cancer and its relationship with brca mutation for the detection of familial breast cancer. we analyzed 84 formalin-fixed, paraffin-embedded tissue blocks from 38 familial breast cancer and 46 nonfamilial ... | 2016 | 27186947 |
| global genomic diversity of human papillomavirus 11 based on 433 isolates and 78 complete genome sequences. | human papillomavirus 11 (hpv11) is an etiological agent of anogenital warts and laryngeal papillomas and is included in the 4-valent and 9-valent prophylactic hpv vaccines. we established the largest collection of globally circulating hpv11 isolates to date and examined the genomic diversity of 433 isolates and 78 complete genomes (cgs) from six continents. the genomic variation within the 2,800-bp e5a-e5b-l1-upstream regulatory region was initially studied in 181/207 (87.4%) hpv11 isolates coll ... | 2016 | 27030261 |
| papillary urothelial carcinoma with squamous differentiation in association with human papilloma virus: case report and literature review. | the human papilloma virus (hpv) is a carcinogen known for its strong association with cervical cancers and cervical lesions. it is also known to be associated with a variety of squamous cell carcinomas in other areas, such as the penis, vulva, anus and head and neck. however, the association with urothelial carcinoma remains controversial. here, we report a case of urothelial carcinoma with squamous differentiation associated with hpv-6/hpv-11. | 2016 | 27069958 |
| requirement for the e1 helicase c-terminal domain in papillomavirus dna replication in vivo. | the papillomavirus (pv) e1 helicase contains a conserved c-terminal domain (ctd), located next to its atp-binding site, whose function in vivo is still poorly understood. the ctd is comprised of an alpha helix followed by an acidic region (ar) and a c-terminal extension termed the c-tail. recent biochemical studies on bovine papillomavirus 1 (bpv1) e1 showed that the ar and c-tail regulate the oligomerization of the protein into a double hexamer at the origin. in this study, we assessed the impo ... | 2016 | 26739052 |
| clinical course of recurrent respiratory papillomatosis: comparison between aggressiveness of human papillomavirus-6 and human papillomavirus-11. | recurrent respiratory papillomatosis (rrp) is mainly associated with human papillomavirus (hpv)6 or hpv11. the purpose of this study was to compare clinical outcome, aggressiveness, and treatment response between hpv6- and hpv11-associated rrp. | 2015 | 24955561 |
| the natural history of genital human papillomavirus among hiv-negative men having sex with men and men having sex with women. | although human immunodeficiency virus (hiv)-negative men having sex with men (msm) bear a substantial burden of human papillomavirus (hpv)-associated disease, prospective studies of genital hpv infection in this population are scarce. | 2015 | 25649172 |
| synthesis and antiviral activity of maleopimaric and quinopimaric acids' derivatives. | a series of maleopimaric and quinopimaric acids' derivatives modified in the e-ring, at the carbonyl- and carboxyl-groups were synthesized and evaluated for their activity in vitro against respiratory viruses (influenza; rhinovirus; adenovirus; and sars), papilloma virus, and hepatitis b and c viruses. the antiviral screening of levopimaric acid diene adducts derivatives was carried out with minimal effect on sars and influenza type b viruses. excellent antiviral activity of the ozonolysis produ ... | 2015 | 26372075 |
| human papilloma virus infection in non-cancerous versus normal esophageal tissue samples by endoscopy. | cancers are the second most common cause of non-accidental deaths in iran, after cardiovascular mortality. although most cases of esophageal squamous cell carcinoma (escc) in the usa and western populations have been attributed to high levels of exposure to tobacco and alcohol, but in iranian populations, other risk factors especially infectious agents have been postulated as possible causes, particularly human papillomavirus (hpv). this study aimed to determine the prevalence and the types of h ... | 2015 | 26221490 |
| seroprevalence and seroincidence of herpes simplex virus (2006-2010), syphilis (2006-2010), and vaccine-preventable human papillomavirus subtypes (2000-2010) among us military personnel. | sexually transmitted infections have historically been burdensome in military populations. we describe the seroprevalence and seroincidence of vaccine-preventable human papillomavirus (vp-hpv) subtypes in a sample of 200 servicemen, along with the seroprevalence and seroincidence of herpes simplex virus (hsv-1/2) and syphilis in a sample of 200 men and 200 women. | 2015 | 25868137 |
| electrocautery resection, shaving with a scalpel, and podophyllin: a combination therapy for giant condyloma acuminatum. | giant condyloma acuminatum (also known as buschke-löwenstein tumor) is a rare disease, for which the treatment of choice is still controversial. in the case described in this report, we used a combination of electrocautery and a surgical scalpel to resect a huge genital wart, followed by long-term local treatment with podophyllin. this procedure was relatively fast, easy to perform, involved minimal bleeding, and did not result in any complications. moreover, combination therapy enabled us to av ... | 2015 | 25927062 |
| [expression and polyclonal antibody preparation of hpv-11e7 protein]. | to express human papillomavirus type 11, e7 protein (hpv11e7) via a prokaryotic expression vector and produce anti-hpv11e7 polyclonal antibody. | 2014 | 24909284 |
| an unusual, giant and benign condyloma acuminatum lesion on the genital area for more than a decade. | condyloma acuminatum, is a rare sexually transmitted disease. the virus responsible for condyloma is human papillomavirus.hpv-6 and hpv-11 are the most commonly detected hpv genotypes, but at least 20 other hpv genotypes have occasionally been found in genital wart tissue specimens. in fact genital hpv infection is common among sexually active populations. this disease may occur at any age after puberty and always seen in the mucosal area. it is characterized by slow growth. we reported here a c ... | 2014 | 25405121 |
| prevalence of human papilloma virus among women with breast cancer since 2005-2009 in isfahan. | human papilloma virus (hpv) dna has been detected in breast carcinoma by different laboratorial techniques, suggesting that the virus could play a role in the pathogenesis of this tumor. | 2014 | 24627883 |
| risk factors of the vertical transmission of human papilloma virus in newborns from singleton pregnancy - preliminary report. | the aim of this study was to analyze the relationship between the frequency of human papilloma virus (hpv) isolation in pregnant women and their offspring, and to assess the risk of maternal-neonatal transmission. | 2014 | 23697795 |
| melting profiles may affect detection of residual hpv l1 gene dna fragments in gardasil®. | gardasil® is a quadrivalent human papillomavirus (hpv) protein-based vaccine containing genotype-specific l1 capsid proteins of hpv-16, hpv-18, hpv-6 and hpv-11 in the form of virus-like-particles (vlps) as the active ingredient. the vlps are produced by a dna recombinant technology. it is uncertain if the residual hpv l1 gene dna fragments in the vaccine products are considered contaminants or excipients of the gardasil® vaccine. because naked viral dna fragments, if present in the vaccine, may ... | 2014 | 24083601 |
| human papillomavirus and its influence on head and neck cancer predisposition. | human papillomavirus (hpv) is a virus often infecting humans. it is often present on skin or mucous membranes. these diverse dna viruses are often linked to many various benign and malignant neoplastic lesions. over 40 types of hpv are transmitted through sexual contact and infect the anogenital region which might be secondly transmitted to the oral mucous. over 150 hpv viruses are defined according to the invaded site. oral papillomas are marked with numbers 6, 7, 11, 16 and 32. squamous cell p ... | 2013 | 24018424 |
| lung squamous cell carcinoma arising in a patient with adult-onset recurrent respiratory papillomatosis. | a 75-year-old male was admitted to our hospital in december 2011 with a mass in the right upper pulmonary lobe. he was incidentally diagnosed as having tracheal papillomas 10 years ago. bronchoscopy revealed multiple polypoid papillomas in the dorsal lesion of the trachea. polymerase chain reaction amplification detected human papillomavirus type 11 dna in the papilloma tissues. a computed tomography scan demonstrated the occlusion of the right superior segment bronchus with distal consolidation ... | 2013 | 23110763 |
| anal and perianal squamous carcinomas and high-grade intraepithelial lesions exclusively associated with "low-risk" hpv genotypes 6 and 11. | anal squamous cell carcinomas are predominantly associated with high-risk human papillomaviruses (hpvs), particularly hpv 16, similar to cervical, vaginal and vulvar cancers. although the presence of "low-risk" hpvs, in particular genotypes 6 and 11, have occasionally been reported in various hpv-related anogenital cancers, the overall distribution of these genotypes in the anal canal and perianal tissue may differ to that in the cervix. in addition, although the majority of anal and perianal ca ... | 2013 | 23616200 |
| seroprevalence of hpv vaccine types 6, 11, 16 and 18 in hiv-infected and uninfected women from brazil. | information on vaccine-type hpv seroprevalence is essential for vaccine strategies; however, limited data are available on past exposure to hpv-quadrivalent vaccine types in hiv-infected woman in brazil. | 2013 | 23490398 |
| a case of esophageal squamous cell carcinoma with positive hpv 11. | hpv (human pappiloma virus) infection is an etiologic risk factor for esophageal carcinoma with several studies supporting its carcinogenic role. the main strains are hpv16 and 18 and the less frequent strains 11, 6, 31 and 36. we report the case of a 58 year old male, smoker, admitted to our hospital for progressive dysphagia. previous endoscopies and biopsies were compatible with a hyperkeratotic esophagus, negative for dysplasia. second endoscopy showed a hyperkeratotic, verrucous, esophagus ... | 2013 | 23195756 |
| genomic differences in the background of different severity in juvenile-onset respiratory papillomatoses associated with human papillomavirus type 11. | this study aimed to compare complete genome sequences of human papillomavirus (hpv) type 11 from two solitary papillomas (considered minimally aggressive), two moderately (six and nine episodes) and two highly aggressive (30 and 33 episodes) juvenile-onset respiratory papillomatoses. genomic regions were sequenced using the sanger method; sequences were compared to available genbank genomes. activity of the long control region (lcr) was assessed in hep-2 cell line using luciferase assays and com ... | 2013 | 23649705 |
| human papillomavirus and other genital infections in indigenous women from paraguay: a cross-sectional analytical study. | the incidence of cervical cancer in paraguay is among the highest in the world, with the human papillomavirus (hpv) being a necessary factor for cervical cancer. knowledge about hpv infection among indigenous women is limited. this cross-sectional study analyzed the frequency of hpv and other genital infections in indigenous paraguayan women of the department of presidente hayes. | 2013 | 24206645 |
| assessment of human papilloma virus infection in adult laryngeal papilloma using a screening test. | human papilloma virus (hpv) infection is involved in both juvenile and adult laryngeal papilloma. we wished to determine which types of adult laryngeal papilloma were clinically related to hpv infection. we hypothesized that multiple-site and recurrent papillomas would have a strong relationship to hpv and conducted the present study to test this hypothesis. | 2012 | 23273988 |
| occurrence of vaccine and non-vaccine human papillomavirus types in adolescent finnish females 4 years post-vaccination. | control of human papillomavirus (hpv)-related cancers by inclusion of hpv vaccination into national vaccination programmes is likely. one open question is replacement of the vaccine types with other high-risk (hr) hpv types in the vaccination era. we studied occurrence of hpv types in adolescent females participating in a population-based vaccination trial. a total of 4,808 16- to 17-year-old females from finland were enrolled in the 1:1 randomized phase iii (patricia) trial of the efficacy of v ... | 2012 | 22492244 |
| the role of human papilloma virus (hpv) genotyping in recurrent respiratory papillomatosis in rasoul akram hospital. | the most common laryngeal mass in children is recurrent respiratory papillomatosis (rrp). studies have attempted to correlate viral typing and its aggressiveness. | 2012 | 23483670 |
| nuclear domain 10-associated proteins recognize and segregate intranuclear dna/protein complexes to negate gene expression. | dna viruses, such as herpes simplex virus type 1 (hsv-1), simian virus 40 (sv40), and cytomegaloviruses (cmv), start their replicative processes and transcription at specific nuclear domains known as nd10 (nuclear domain 10, also called pml bodies). it has been previously determined that for hsv-1 and sv40, a short dna sequence and its binding protein are required and sufficient for cell localization of viral dna replication and gene transcription. | 2012 | 23021128 |
| use of reprogrammed cells to identify therapy for respiratory papillomatosis. | a patient with a 20-year history of recurrent respiratory papillomatosis had progressive, bilateral tumor invasion of the lung parenchyma. we used conditional reprogramming to generate cell cultures from the patient's normal and tumorous lung tissue. analysis revealed that the laryngeal tumor cells contained a wild-type 7.9-kb human papillomavirus virus type 11 (hpv-11) genome, whereas the pulmonary tumor cells contained a 10.4-kb genome. the increased size of the latter viral genome was due to ... | 2012 | 23013073 |
| seroprevalence of human papillomavirus types 6, 11, 16 and 18 in chinese women. | human papillomavirus (hpv) seroprevalence data have not previously been reported for different geographical regions of china. this study investigated the cross-sectional seroprevalence of antibodies to hpv 6, 11, 16, and 18 virus-like particles in chinese women. | 2012 | 22715915 |
| role of the association of high-risk hpv identified by real-time pcr in cervical preneoplastic lesions. | to evaluate the effects of infection in multiple types of high-risk human papilloma virus (hpv) in cervical preneoplastic lesions in patients undergoing colposcopy following a diagnosis of atypical squamous cells of unknown significance (ascus) and low-grade squamous intraepithelial (lsil) cytology. | 2012 | 23185789 |
| Identification and analysis of papillomavirus e2 protein binding sites in the human genome. | Papillomavirus E2 protein is required for the replication and maintenance of viral genomes and transcriptional regulation of viral genes. E2 functions through sequence-specific binding to 12-bp DNA motifs-E2 binding sites (E2BS)-in the virus genome. Papillomaviruses are able to establish persistent infection in their host and have developed a long-term relationship with the host cell in order to guarantee the propagation of the virus. In this study, we have analyzed the occurrence and functional ... | 2012 | 22031941 |
| population attributable fraction of infection-related cancers in korea. | a number of infectious agents have been classified as human carcinogens. the purpose of the current study was to provide an evidence-based assessment of the burden of infection-related cancers in the korean population. materials and methods: the population attributable fraction was calculated using infection prevalence data from 1990 or earlier, relative risk estimates from meta-analyses using mainly korean studies and national data on cancer incidence and mortality for the year 2007. | 2011 | 20974652 |
| detection of high-risk human papillomavirus types 16 and 18 but not 33 and 52 in external genital warts from iranian females. | background: external genital warts (egw) are relatively common sexually transmitted diseases. in the majority of cases, low-risk human papilomaviruses (hpv), such as hpv-6 and hpv-11, are responsible but, high-risk types may also be detected and this has a bearing on vaccines for cervical cancer prevention. in this study the incidence of the high-risk hpv types 16, 18, 33 and 52 in egws of females from the southwest of iran was assessed. methods: seventy-nine women with egws participated in this ... | 2011 | 21627381 |
| virological failure of intralesional cidofovir therapy in recurrent respiratory papillomatosis is not associated with genetic or epigenetic changes of hpv11: complete genome comparison of sequential isolates. | five sequential human papillomavirus type 11 (hpv11) positive samples collected from an aggressive juvenile onset recurrent respiratory papillomatosis before, during and after intralesional cidofovir therapy leading to virological failure after initial response were analyzed. sequencing of the complete genome as well as methylation analysis by bisulfate modification and sequencing of the long control region (lcr) were performed to seek for genetic and epigenetic changes as a possible background ... | 2011 | 21945249 |
| human papillomavirus (hpv) 6, 11, 16, and 18 seroprevalence is associated with sexual practice and age: results from the multinational hpv infection in men study (him study). | few human papillomavirus (hpv) serology studies have evaluated type-specific seroprevalence of vaccine hpv types in men. this study investigates seroprevalence of hpv 6, 11, 16, and 18, and associated risk factors in men residing in three countries (united states, mexico, and brazil). | 2011 | 21378268 |
| tracheal papillomatosis: what do we know so far? | tracheal papillomatosis (tp) is a benign condition characterized by papillomatous growth of the bronchial epithelium that involves the trachea. this abnormal growth is a result of infection with human papilloma virus (hpv). two subtypes of hpv were found in most cases of tp, hpv-6 and hpv-11. tp, presents in two forms, the juvenile onset (jo) or adult onset (ao). the clinical presentation is typically nonspecific and it ranges from mild symptoms like cough to life-threatening conditions like upp ... | 2011 | 21971565 |
| incidence of low risk human papillomavirus in oral cancer: a real time pcr study on 278 patients. | squamous cell carcinoma is the most frequent malignant tumour of the oral cavity. it is widely known that tobacco and alcohol consumption are the major causes of the development of oral squamous cell carcinoma (oscc). the human papilloma virus infection has also been postulated as a risk factor for squamous cell carcinoma, although conflicting results have been reported. the aim of this study is to evaluate the presence of high-risk and low-risk type human papillomavirus in a large sample of squ ... | 2011 | 21781451 |
| conjunctival papilloma caused by human papillomavirus type 11 treated with systemic interferon in a five-year-old boy. | conjunctival papilloma is a benign tumor of the conjunctival mucosa. in childhood, papilloma represents 7-10% of conjunctival tumors. human papillomavirus (hpv)-6 and hpv-11 are the major hpv types responsible for conjunctival lesions. a five-year-old boy with a two-year history of conjunctival papilloma caused by hpv type 11 treated with systemic interferon alpha is reported and the literature is reviewed. | 2010 | 20402076 |
| inducible heat shock protein 70 enhances hpv31 viral genome replication and virion production during the differentiation-dependent life cycle in human keratinocytes. | increasing data indicate heat shock proteins (hsps) including inducible hsp70 (hsp70i) are involved in the replicative cycles of various viruses including adenoviruses (ads), polyomaviruses (pyvs), and some rna viruses. cell-free system studies implicate hsp70i in human papillomavirus type 11 (hpv11) genome replication with e1 and e2 proteins, and there is evidence that hsp70 is involved in capsid assembly and disassembly for pyvs and hpvs. hsp70 expression is increased in hpv16 e6/e7 gene trans ... | 2010 | 19896513 |
| human papillomavirus e2 protein with single activation domain initiates hpv18 genome replication, but is not sufficient for long-term maintenance of virus genome. | the papillomavirus life cycle is regulated by a family of proteins encoded by the e2 open reading frame; e2 proteins regulate viral gene expression, dna replication and genome maintenance. we have previously shown that the bovine papillomavirus (bpv1) full-length e2 protein forms heterodimers with repressor forms of e2, and these e2 heterodimers serve as activators of transcription and replication during the viral life cycle. in the present study, using the single-chain e2 heterodimer as a model ... | 2010 | 20940072 |
| betulin and ursolic acid synthetic derivatives as inhibitors of papilloma virus. | the synthesis of new betulin and ursolic acid derivatives and evaluation of their antiviral activity in vitro is reported. betulin was modified at positions c-3, c-20 and c-28 to afford the derivatives with nicotinoyl-, methoxycynnamoyl-, alkyne and aminopropoxy-2-cyanoethyl-moieties. the two stage conversion of betulin to the new ursane-type triterpenoid by treatment of allobetulin with ac(2)o-hclo(4) is suggested. cyanoethylation of ursonic acid oxime led to cyanoethyloximinoderivative. accord ... | 2010 | 20558062 |
| differential expression of cellular micrornas in hpv-11 transfected cells. an analysis by three different array platforms and qrt-pcr. | human papillomavirus type 11 (hpv-11) infects the genital and the respiratory tract leading to condylomas and respiratory papillomatosis. hpv infections are restricted to epithelial tissue and the progression through the virus lifecycle is tightly coordinated to the differentiation of the host cell. the changes of cellular micrornas by hpv-11 gene expression were investigated in a cell culture model of hacat cells transfected with hpv-11, with the goal of understanding which cellular processes w ... | 2010 | 21078297 |
| [synthesis of triterpenoid acylates - an effective reproduction inhibitors of influenza a (h1n1) and papilloma viruses]. | the synthesis of a new group of triterpenoid acylates on the basis of oleanolic, glycyrrhetic and ursolic acids and betulin is described. in studying the activity of the synthesized compounds in relation to reproduction of virus pathogens of respiratory infections 28-o-methoxycynnamoylbetulin shows high activity against influenza type a (h1n1) the selectivity index si > 100. the high activity of 3,28-dinicotinoylbetulin against papilloma virus (strain hpv-11) was detected, the selectivity index ... | 2010 | 21317951 |
| novel human papilloma virus (hpv) genotypes in children with recurrent respiratory papillomatosis. | recurrent respiratory papillomatosis (rrp) is characterized by the presence of benign virally induced tumors of the larynx and respiratory epithelium that may obstruct the airway and tend to recur frequently. rrp is caused by the human papilloma virus (hpv), most frequently by hpv types 6 and 11. in this study, we present four cases of children with rrp in whom hpvs other than hpv-6 or hpv-11 were found. | 2010 | 20213305 |
| human papillomavirus and epstein barr virus in oral hairy leukoplakia among hiv positive venezuelan patients. | oral hairy leukoplakia (ohl) is commonly found in individuals infected with hiv and represents the most frequent oral manifestation. the purpose of this study was to detect the presence of human papillomavirus (hpv) and epstein barr virus (ebv) in ohl of hiv+ venezuelan patients. we evaluated 21 hiv+ adult patients with clinically present ohl lesions: 11 under antiretroviral therapy, 10 without therapy, and 10 oral mucosal samples as controls. nested-pcr was used to detect ebv and hpv infection. ... | 2010 | 21053684 |
| rna interference silences the human papillomavirus 6b/11 early gene e7 in vitro and in vivo. | rna interference (rnai) is a potential therapeutic tool in the treatment of various diseases, such as cancers and viral infections. silencing of e7 genes is an effective method to suppress human papilloma virus (hpv)-related tumours. | 2010 | 19874368 |
| transitional cell neoplasm of the nasolacrimal duct associated with human papillomavirus type 11. | tumors of the lacrimal sac are rare but noteworthy because of their significant potential to become malignant or life-threatening if treatment is delayed. dermatologists may be the first to encounter such neoplasms. | 2010 | 19615034 |
| differential binding patterns to host cells associated with particles of several human alphapapillomavirus types. | the focus of this research was to compare the binding profiles of human papillomavirus (hpv) 11, 16, 18 and 45 virus-like particles (vlps) to hacat cells and to the extracellular matrix (ecm) secreted by these cells. all four hpv types tested bind to a component(s) of the ecm. hpv11 vlp binding is blocked when the ecm is pretreated with an anti-laminin 5 (ln5) polyclonal antibody. a series of treatments utilizing heparins and heparinase revealed that hpv18 vlps are dependent on heparan sulfates ... | 2010 | 19846678 |
| malignant transformation of a highly aggressive human papillomavirus type 11-associated recurrent respiratory papillomatosis. | the objective is to present an uncommon case of squamous cell carcinoma (scc) arising from extensive recurrent respiratory papillomatosis (rrp) involving the upper and lower airway and temporal bone. | 2010 | 20015762 |
| characterization of human papillomavirus type 11-specific immune responses in a preclinical model. | human papillomavirus (hpv) types 6 and 11 are associated with recurrent respiratory papillomatosis (rrp). although a prophylactic vaccine has been developed that protects against hpv infection, a therapeutic vaccine is still needed for those patients infected with and/or suffering from persistent disease. therefore, we developed a novel, therapeutic dna vaccine targeting hpv-11 and characterized the in vivo immunologic responses generated against hpv-11 e6 and e7 after dna vaccination in a precl ... | 2010 | 20025042 |
| [expression, purification and immunogenicity of human papillomavirus type 11 virus-like particles from escherichia coli]. | to produce human papillomavirus type 11 virus-like particles (hpv11 vlps) from escherichia coli and to investigate its immunogenicity and type cross neutralization nature. | 2009 | 20112683 |
| [construction and immunogenicity evaluation of chimerical dna vaccine of human papillomavirus type 11]. | to construct chimerical dna vaccine plasmid of human papillomavirus type 11 (hpv11) l1-e7, and to evaluate its immunogenicity. | 2009 | 20104772 |
| diseases caused by human papillomaviruses (hpv). | human papillomaviruses (hpv) are non-enveloped tumor viruses with a double stranded dna approximately 8 kilobases in length. the viral genome is enclosed by a spherical capsid with icosahedral symmetry and a diameter of about 55 nm. more than 100 hpv types have been identified. they infect the squamous epithelia of skin and mucosa and usually cause benign papillomas or warts. persistent infection with high-risk oncogenic hpv causes all cervical cancers, most anal cancers, and a subset of vulvar, ... | 2009 | 19302229 |
| human papilloma virus type and recurrence rate after surgical clearance of anal condylomata acuminata. | anal condylomata acuminata (aca) are caused by human papilloma virus (hpv) infection which is transmitted by close physical and sexual contact. the result of surgical treatment of aca has an overall success rate of 71% to 93%, with a recurrence rate between 4% and 29%. the aim of this study was to assess a possible association between hpv type and aca recurrence after surgical treatment. | 2009 | 19543141 |
| anal condyloma acuminatum. | anal condyloma acuminatum is a human papillomavirus (hpv) that affects the mucosa and skin of the anorectum and genitalia. anal condyloma acuminatum is the most commonly diagnosed sexually transmitted disease in the united states. to date, there are more than 100 hpv types, with hpv-6, hpv-10, and hpv-11 predominately found in the anogenital region and causing approximately 90% of genital warts. risk factors for anal condyloma acuminatum include multiple sex partners, early coital age, anal inte ... | 2009 | 19820442 |
| anal hpv genotypes and related displasic lesions in italian and foreign born high-risk males. | anal intraepithelial neoplasia and anal cancer are closely related to infection from high-risk human papilloma virus (hpv) genotypes. since hpvs involved in disease progression are reported to vary by geographical regions, this study focuses on hpv genotypes spectrum in 289 males attending a sexual transmitted diseases (std) unit according to their nationality. anal cytology, digene hybrid capture assay (hc2) and hpv genotyping were evaluated in 226 italian (it) and 63 foreign born (fb) subjects ... | 2009 | 19480957 |
| safety and immunogenicity of co-administered quadrivalent human papillomavirus (hpv)-6/11/16/18 l1 virus-like particle (vlp) and hepatitis b (hbv) vaccines. | adolescents and young adults are at high risk for human papillomavirus (hpv) and hepatitis b virus (hbv) infections, which are preventable by currently available, safe and effective, prophylactic vaccines. however, development of a combined immunization strategy may lead to better compliance for these vaccines, thereby contributing to the overall goal of protection against these diseases. this study assessed the safety and immunogenicity of co-administered quadrivalent hpv-6/11/16/18 l1 vlp and ... | 2008 | 18164106 |
| mapping of cytotoxic t lymphocytes epitopes in e7 antigen of human papillomavirus type 11. | one of the critical steps in the progression to condyloma acuminatum (ca) is the establishment of a persistent human papillomavirus (hpv) infection, majority of hpv type 6 and 11. cytotoxic t lymphocytes (ctl), which can be induced by the epitope-based peptides in vitro, are thought to be able to recognize and destroy virus-infected cells. in order to screen and identify hla-a*0201 restricted hpv-11e7 ctl epitopes, five epitope peptides and tetramers were selected including hpv-11e7 7-15 (tlkdiv ... | 2008 | 18299861 |
| conjunctival condylomata acuminata. | to report a case of sexually transmitted conjunctival squamous papillomas and to propose a new term for this condition. | 2008 | 18520518 |
| possible role for cellular karyopherins in regulating polyomavirus and papillomavirus capsid assembly. | polyomavirus and papillomavirus (papovavirus) capsids are composed of 72 capsomeres of their major capsid proteins, vp1 and l1, respectively. after translation in the cytoplasm, l1 and vp1 pentamerize into capsomeres and are then imported into the nucleus using the cellular alpha and beta karyopherins. virion assembly only occurs in the nucleus, and cellular mechanisms exist to prevent premature capsid assembly in the cytosol. we have identified the karyopherin family of nuclear import factors a ... | 2008 | 18701594 |
| prevalence of genital human papilloma virus infection and genotypes among young women in sicily, south italy. | infection with oncogenic human papilloma virus (hpv) types is a necessary cause of cervical cancer. this study assessed the prevalence of hpv infection and genotypes among 1,006 randomly selected women, ages 18 to 24 years, living in sicily (south italy). the overall hpv rate was 24.1% (95% confidence interval, 21.5-26.9). the most frequent types were hpv-16 (4.5%), hpv-53 (2.7%), and hpv-84 (2.6%). the prevalence of vaccine types hpv-6, hpv-11, and hpv-18 was 1.4%, 0.1%, and 1.3%, respectively. ... | 2008 | 18708390 |
| oral inverted ductal papilloma associated with condyloma acuminata and hpv in an hiv+ patient. | oral inverted ductal papillomas are rare benign tumours of minor salivary glands. a case that appeared in a middle-aged hiv+ woman simultaneous to two condyloma acuminata on the lips is described. the presence of human papilloma virus (hpv) 11 dna was demonstrated in all the samples using polymerase chain reaction. hpv could play an important role in the aetiology and pathogenesis of these lesions in this patient. | 2008 | 18774261 |
| e6 and e7 oncogene expression by human papilloma virus (hpv) and the aggressive behavior of recurrent laryngeal papillomatosis (rlp). | recurrent laryngeal papillomatosis (rlp), a chronic disease associated with human papilloma virus (hpv), requires serial surgical procedures for debulking, resulting in debilitating long-term dysphonia, laryngeal scarring, and rarely malignant degeneration. human papilloma virus 11 tumors have been widely accepted as more aggressive than hpv 6 tumors; however, the clinical course has been difficult to predict at disease onset, and the biologic mediators of proliferation have not been well charac ... | 2008 | 17990904 |
| remodeling of the human papillomavirus type 11 replication origin into discrete nucleoprotein particles and looped structures by the e2 protein. | the human papillomavirus (hpv) dna replication origin (ori) shares a common theme with many dna control elements in having multiple binding sites for one or more proteins spaced over several hundreds of base pairs. the hpv type 11 ori spans 103 bp and contains three palindromic e2 binding sites (e2bs-2, e2bs-3, and e2bs-4) for the dimeric e2 ori binding protein. these sites are separated by 64 and 3 bp. e2bs-1 is located 288 bp upstream of e2bs-2 and is not required for efficient transient or ce ... | 2008 | 18067922 |
| seroepidemiology of human papillomavirus type 11 in the united states: results from the third national health and nutrition examination survey, 1991--1994. | the national seroprevalence of the nononcogenic human papillomavirus (hpv) type 11, one of the types targeted by the quadrivalent hpv vaccine, has not been evaluated in the united states. the objectives of this study were to estimate the national seroprevalence and evaluate predictors of hpv-11 seropositivity. | 2008 | 18091027 |
| [vaccine against human papilloma virus]. | genital human papilloma virus infection (hpv) is the most common sexually transmitted infection worldwide, it is the cause of genital warts, and it is related with cervical cancer, the second most common cause of death from cancer in women in america, and the first in underdeveloped countries, and it is related with penis and prostate cancer in males also, and with anal cancer in both genders. this review examines the most important actual facts about hpv infection, and the new prophylactic vacc ... | 2008 | 19263667 |
| expression of the hpv11 e2 gene in transgenic mice does not result in alterations of the phenotypic pattern. | the e2 early protein of human papillomaviruses (hpv) has been found associated with the mitotic spindle therefore being implicated in the partition of the replicated viral dna to daughter cells. in addition, e2 proteins bind to the upstream regulatory region of the virus and to cellular promoters modulating thereby cellular transcription and differentiation. in many cervical cancers, the e2 reading frame is interrupted upon incorporation of the viral genome into the host dna. this results in the ... | 2008 | 17701441 |
| high incidence of malignant transformation of laryngeal papilloma in taiwan. | papillomas of the larynx include solitary laryngeal papilloma and recurrent respiratory papillomatosis. this study investigated the incidence of malignant transformation and assessed possible risk factors for laryngeal papillomas. | 2008 | 17975511 |
| detection of human papillomavirus type 11 in a case of buschke-löwenstein tumor. | we here report a 31-year-old male affected by a papillary tumor in his pubic region. at 26 years of age, he consulted a nearby clinic and was prescribed a topical cream. although the condition was not relieved, he left the disease untreated. the gradually growing tumor adversely affected his quality of life, and he consulted another clinic, where he was referred to our hospital for surgery. the tumor had infiltrated the tissue at the base of the penis, but not the glans. after careful examinatio ... | 2008 | 18474465 |
| association of e6ap (ube3a) with human papillomavirus type 11 e6 protein. | the cellular e3 ubiquitin ligase e6ap (ube3a) interacts with the cancer-associated hpv e6 oncoproteins, where together with the viral e6 oncoprotein it binds and targets the degradation of the p53 tumor suppressor. we find that the hpv-11e6 protein also associates with e6ap in vivo, and thereby can target the degradation of an e6-associated protein. mutation of an e6-binding lxxll peptide motif on e6ap eliminated the association, revealing a common mode of interaction between high- and low-risk ... | 2007 | 17023019 |
| prophylactic dna immunization against multiple papillomavirus types. | at least 15 different papillomavirus types are causatively associated with the development of tumors in humans. since the middle of 2006 a protective, virus-like particle based vaccine against the tumor-related hpv types 16 and 18 is commercially available. we investigated the possibility of applying dna vaccination to obtain protective antibody responses against multiple papillomavirus types. our data indicate that low amounts of dna were sufficient to induce neutralizing antibodies in mice alt ... | 2007 | 17485151 |
| [prokaryotic expression and purification of human papillomavirus type 11 l2e7 fusion protein vaccine and its immunnogenicity]. | to construct the escherichia coli (e. coli) prokaryotic expression system pet9ahpv11l2e7, purify the fusion protein l2e7 and study the immunnogenicity of the protein. | 2007 | 17653322 |
| mitogen-activated protein kinases activate the nuclear localization sequence of human papillomavirus type 11 e1 dna helicase to promote efficient nuclear import. | human and animal papillomavirus dna replicates as multicopy nuclear plasmids. replication requires two viral proteins, the origin-recognition protein e2 and the replicative dna helicase e1. using genetic, biochemical, and immunofluorescence assays, we demonstrated that efficient nuclear import of the human papillomavirus (hpv) type 11 e1 protein depends on a codominant bipartite nuclear localization sequence (nls) and on phosphorylation of the serine residues s89 and s93 by the mitogen-activated ... | 2007 | 17344281 |
| incidence and duration of cervical human papillomavirus 6, 11, 16, and 18 infections in young women: an evaluation from multiple analytic perspectives. | to estimate the incidence and duration of cervical human papillomavirus (hpv)-6, hpv-11, hpv-16, and hpv-18 infections in a population of young american women. | 2007 | 17416761 |
| type-specific and cross-reactive antibodies induced by human papillomavirus 31 l1/l2 virus-like particles. | the aim of this study was to determine whether antibodies induced by human papillomavirus (hpv) type 31 l1/l2 virus-like particles (vlps) could cross-react with vlps of the closely related hpv-16 and distantly related hpv-11, and to investigate the potential role of the l2 protein in l1/l2 vlps in inducing cross-neutralizing antibodies. antisera were prepared from rabbits immunized with intact or denatured hpv-31 l1/l2 vlps. cross-reaction and cross-neutralization were analysed by western blotti ... | 2007 | 17577054 |
| optimization and determination of the absolute configuration of a series of potent inhibitors of human papillomavirus type-11 e1-e2 protein-protein interaction: a combined medicinal chemistry, nmr and computational chemistry approach. | we have previously reported the discovery and initial sar optimization of the first series of inhibitors of the human papillomavirus type-11 (hpv11) e1-e2 protein-protein interaction. these inhibitors featured an indandione system spiro-fused onto an all syn substituted tetrahydrofuran ring. in this paper, we report new sar efforts which have led to the identification of the first low nanomolar inhibitor of the hpv11 e1-e2 protein-protein interaction. in addition, we report a combined nmr and co ... | 2007 | 17306550 |
| prevalence of bk virus and human papillomavirus in human prostate cancer. | polyomaviruses such as the bk virus (bkv), jc virus (jcv) and sv40, as well as the human papillomaviruses (hpv) are frequently detected throughout human populations, causing subclinical persistent infections and inducing oncogenesis in human and other cell lines. to test the involvement of these viruses in prostate tumorigenesis, we investigated the prevalence of bkv, jcv and hpv in a series of human prostatic malignancies. forty-two samples of diagnosed prostatic malignancies were tested using ... | 2007 | 18161654 |
| do g protein-coupled receptors expressed in human lingual epithelium interact with hpv11? | human papillomaviruses infect epithelia but little is known about the nature of cell surface receptors interacting with the viral particles. it has been proposed that glycosaminoglycans and integrins may be involved in the attachment process. in the present study, the putative interactions of virus-like particles of human papillomavirus type 11 (hpv11), which present a tropism for nasopharyngeal epithelia, with olfactory and taste receptors expressed in the human lingual epithelium were studied. ... | 2007 | 17705193 |
| expression of hpv-11 l1 protein in transgenic arabidopsis thaliana and nicotiana tabacum. | we have investigated the possibility and feasibility of producing the hpv-11 l1 major capsid protein in transgenic arabidopsis thaliana ecotype columbia and nicotiana tabacum cv. xanthi as potential sources for an inexpensive subunit vaccine. | 2007 | 17850660 |
| [study on the genotyping of human papillomavirus using a new dna liquid chip in women of high-risk group of shandong province]. | to evaluate the diagnostic applicability of human papillomavirus (hpv) liquid chip assay which is based on luminex xmap system, and perform a hpv epidemiologic study with the liquid chip in women of shandong province. | 2007 | 17877181 |
| sexually transmitted infections, bacterial vaginosis, and candidiasis in women of reproductive age in rural northeast brazil: a population-based study. | population-based data on sexually transmitted infections (sti), bacterial vaginosis (bv), and candidiasis reflect the epidemiological situation more accurately than studies performed in specific populations, but such data are scarce. to determine the prevalence of sti, bv, and candidiasis among women of reproductive age from a resource-poor community in northeast brazil, a population-based cross sectional study was undertaken. all women from seven hamlets and the centre of pacoti municipality in ... | 2007 | 17924006 |
| the seroprevalence of igg antibodies to human papillomavirus (hpv) types hpv-16, hpv-18, and hpv-11 capsid-antigens in mothers and their children. | human papillomavirus (hpv) types causing anogenital lesions and cancer are accepted as being sexually transmitted. the methods whereby children acquire these anogenital type hpv infections are unclear. the present study determined the prevalence of anti-hpv-16, hpv-11 and hpv-18 igg antibodies in mothers and their children in an attempt to identify evidence of hpv transmission from mother to child. hpv virus-like particles (vlp) vlp-16, vlp-11 and vlp-18 were used in enzyme-linked immunosorbent ... | 2007 | 17607783 |
| an inhibitor of the epidermal growth factor receptor function does not affect the ability of human papillomavirus 11 to form warts in the xenografted immunodeficient mouse model. | epidermal growth factor receptor (egfr) has been shown to be induced and activated in cells infected with hpv, suggesting that it may play a physiological role in viral replication or in the formation or maintenance of warts. to investigate this possibility, human foreskin tissue was infected with hpv11 and transplanted onto the renal capsule and the dermis of immunodeficient mice. the animals were treated orally or topically with the potent egfr inhibitor cp-545130, with treatment starting eith ... | 2007 | 17239450 |
| [study on the frequency of human papillomavirus type 6 and type 11 infection and l1 gene expression of the virus in biopsy samples of pointed condyloma patients]. | to determine the different rates of human papillomavirus types 6 (hpv-6) and 11 (hpv-11) infection in biopsy samples from pointed condyloma patients, and to construct prokaryotic expression system of the major capsid protein l1 of the virus so as to establish an elisa for detecting the expression of l1 gene in the biopsy samples. | 2006 | 16749998 |
| induction of productive human papillomavirus type 11 life cycle in epithelial cells grown in organotypic raft cultures. | the study of the human papillomavirus (hpv) life cycle was hampered for more than 50 years by the lack of a conventional cell culture system for propagating hpv. considerable progress has been made in the production of several hpv types using either organotypic rafts or human epithelial xenografts in immunocompromised mice. in this study, we demonstrated episomal maintenance of hpv-11 dna in n-tert cells. hpv-11 episomal dna containing cell populations grown in raft culture showed induction of t ... | 2006 | 16460777 |
| the human papillomavirus type 11 e1/\e4 protein is not essential for viral genome amplification. | an abundant human papillomavirus (hpv) protein e1/\e4 is expressed late in the virus life cycle in the terminally differentiated layers of epithelia. the expression of e1/\e4 usually coincides with the onset of viral dna amplification. however, the function of e1/\e4 in viral life cycle is not completely understood. to examine the role of e1/\e4 in the virus life cycle, we introduced a single nucleotide change in the hpv-11 genome to result in a truncation of e1/\e4 protein without affecting the ... | 2006 | 16687161 |
| preclinical model to test human papillomavirus virus (hpv) capsid vaccines in vivo using infectious hpv/cottontail rabbit papillomavirus chimeric papillomavirus particles. | a human papillomavirus (hpv) vaccine consisting of virus-like particles (vlps) was recently approved for human use. it is generally assumed that vlp vaccines protect by inducing type-specific neutralizing antibodies. preclinical animal models cannot be used to test for protection against hpv infections due to species restriction. we developed a model using chimeric hpv capsid/cottontail rabbit papillomavirus (crpv) genome particles to permit the direct testing of hpv vlp vaccines in rabbits. ani ... | 2006 | 17005666 |
| factors influencing subcellular localization of the human papillomavirus l2 minor structural protein. | two structural proteins form the capsids of papillomaviruses. the major structural protein l1 is the structural determinant of the capsids and is present in 360 copies arranged in 72 pentamers. the minor structural protein l2 is estimated to be present in twelve copies per capsid. possible roles for l2 in interaction with cell surface receptors and in virion uptake have been suggested. as previously reported, l2 localizes in subnuclear domains identified as nuclear domain 10 (nd10). as it was de ... | 2006 | 16257028 |
| ccaat/enhancer-binding protein beta represses human papillomavirus 11 upstream regulatory region expression through a promoter-proximal yy1-binding site. | ccaat/enhancer-binding protein beta (c/ebpbeta) can function as a repressor or as an activator of human papillomavirus (hpv) gene expression, depending on which cell type the experiments are conducted. in this report, it was shown that within primary human foreskin keratinocyte cells (hfk) the activity of c/ebpbeta can be switched from that of a repressor of hpv11 expression to an activator by mutating a single promoter-proximal consensus yy1-binding site within the hpv11 upstream regulatory reg ... | 2006 | 16361417 |
| presence of human papillomavirus dna in tonsillectomy specimens. | the objectives of this prospective case-control study were to study the prevalence of human papillomavirus (hpv) in tonsillectomy specimens from pediatric patients without recurrent respiratory papillomatosis (rrp), and to study methods of hpv detection. | 2006 | 16885738 |
| more men than women make mucosal iga antibodies to human papillomavirus type 16 (hpv-16) and hpv-18: a study of oral hpv and oral hpv antibodies in a normal healthy population. | we have previously shown the high prevalence of oral anti-human papillomavirus type 16 (hpv-16) antibodies in women with hpv-associated cervical neoplasia. it was postulated that the hpv antibodies were initiated after hpv antigenic stimulation at the cervix via the common mucosal immune system. the present study aimed to further evaluate the effectiveness of oral fluid testing for detecting the mucosal humoral response to hpv infection and to advance our limited understanding of the immune resp ... | 2006 | 16762074 |
| human papilloma virus in hyperplastic tonsillar and adenoid tissues in children. | human papillomavirus (hpv) in childhood causes skin and anogenital warts as well as the recurrent respiratory papillomatosis, a life-threatening cause of upper airway obstruction in children. to date, the information on hpv infection in tonsillar and adenoid hyperplasia in children is limited. | 2006 | 17133162 |