Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| self-collection based hpv testing for cervical cancer screening among women living with hiv in uganda: a descriptive analysis of knowledge, intentions to screen and factors associated with hpv positivity. | women living with hiv (whiv) are disproportionately impacted by cervical dysplasia and cancer. the burden is greatest in low-income countries where limited or no access to screening exists. the goal of this study was to describe knowledge and intentions of whiv towards hpv self-collection for cervical cancer screening, and to report on factors related to hpv positivity among women who participated in testing. | 2017 | 28086933 |
| a highly sensitive quantum dots-dna nanobiosensor based on fluorescence resonance energy transfer for rapid detection of nanomolar amounts of human papillomavirus 18. | a very sensitive and convenient nanobiosensor based on fluorescence resonance energy transfer (fret) was developed for the detection of a 22-mer oligonucleotides sequence in human papillomavirus 18 virus (hpv18) gene. for this purpose, water-soluble cdte quantum dots (qds) were synthesized and, subsequently, amino-modified 11-mer oligonucleotide as one of the two necessary probes was attached to qds surface to form functional qds-dna conjugates. right after addition of the qds-dna and a second c ... | 2017 | 28081500 |
| no evidence for cross-protection of the hpv-16/18 vaccine against hpv-6/11 positivity in female sti clinic visitors. | data from a vaccine trial and from post-vaccine surveillance in the united kingdom have suggested that the bivalent hpv-16/18 vaccine offers cross-protection against hpv-6/11 and protection against anogenital warts (agw). we studied the effect of the bivalent vaccine on genital hpv-6/11 positivity and agw in the netherlands. | 2017 | 28126492 |
| cost-effectiveness analysis of as04-adjuvanted human papillomavirus 16/18 vaccine compared with human papillomavirus 6/11/16/18 vaccine in the philippines, with the new 2-dose schedule. | cervical cancer (cc) is the second leading cause of cancer death among filipino women. human papillomavirus (hpv) vaccination protects against cc. two vaccines (as04-hpv-16/18 and 4vhpv) are approved in the philippines; they were originally developed for a 3-dose (3d) administration and have recently been approved in a 2-dose schedule (2d). this study aims to evaluate the cost-effectiveness of hpv vaccination of 13-year-old filipino girls, in addition to current screening, in the new 2d schedule ... | 2017 | 28075249 |
| what is the predictive value of animal models for vaccine efficacy in humans? the importance of bridging studies and species-independent correlates of protection. | animal models have played a pivotal role in all stages of vaccine development. their predictive value for vaccine effectiveness depends on the pathogen, the robustness of the animal challenge model, and the correlates of protection (if known). this article will cover key questions regarding bridging animal studies to efficacy trials in humans. examples include human papillomavirus (hpv) vaccine in which animal protection after vaccination with heterologous prototype virus-like particles (vlps) p ... | 2017 | 28348035 |
| histopathology of vaccine-preventable diseases. | the widespread use of vaccines has been one of the most important medical advances in the last century, saving trillions of dollars and millions of lives. despite local eradication of some infections, travellers returning from affected areas may cause outbreaks through reintroduction of pathogens to individuals who are unable to receive vaccines for medical reasons or who have declined vaccination for non-medical reasons. infections that would otherwise be uncommonly encountered by anatomical pa ... | 2017 | 27960239 |
| development of an acid-resistant salmonella typhi ty21a attenuated vector for improved oral vaccine delivery. | the licensed oral, live-attenuated bacterial vaccine for typhoid fever, salmonella enterica serovar typhi strain ty21a, has also been utilized as a vaccine delivery platform for expression of diverse foreign antigens that stimulate protection against shigellosis, anthrax, plague, or human papilloma virus. however, ty21a is acid-labile and, for effective oral immunization, stomach acidity has to be either neutralized with buffer or by-passed with ty21a in an enteric-coated capsule (ecc). several ... | 2017 | 27673328 |
| gtl001, a bivalent therapeutic vaccine against human papillomavirus 16 and 18, induces antigen-specific cd8+ t cell responses leading to tumor regression. | prophylactic vaccines are available for women and girls not yet infected with hpv, but women already infected with hpv need a treatment to prevent progression to high-grade cervical lesions and cancer. gtl001 is a bivalent therapeutic vaccine for eradicating hpv-infected cells that contains hpv16 e7 and hpv18 e7 both fused to detoxified adenylate cyclase from bordetella pertussis, which binds specifically to cd11b+ antigen-presenting cells. this study examined the ability of therapeutic vaccinat ... | 2017 | 28301611 |
| gtl001 and bivalent cyaa-based therapeutic vaccine strategies against human papillomavirus and other tumor-associated antigens induce effector and memory t-cell responses that inhibit tumor growth. | gtl001 is a bivalent therapeutic vaccine containing human papillomavirus (hpv) 16 and hpv18 e7 proteins inserted in the bordetella pertussis adenylate cyclase (cyaa) vector intended to prevent cervical cancer in hpv-infected women with normal cervical cytology or mild abnormalities. to be effective, therapeutic cervical cancer vaccines should induce both a t cell-mediated effector response against hpv-infected cells and a robust cd8(+) t-cell memory response to prevent potential later infection. ... | 2017 | 28196735 |
| the cellular dna helicase chlr1 regulates chromatin and nuclear matrix attachment of the human papillomavirus 16 e2 protein and high-copy-number viral genome establishment. | in papillomavirus infections, the viral genome is established as a double-stranded dna episome. to segregate the episomes into daughter cells during mitosis, they are tethered to cellular chromatin by the viral e2 protein. we previously demonstrated that the e2 proteins of diverse papillomavirus types, including bovine papillomavirus (bpv) and human papillomavirus 16 (hpv16), associate with the cellular dna helicase chlr1. this virus-host interaction is important for the tethering of bpv e2 to m ... | 2017 | 27795438 |
| quadrivalent vaccine-targeted human papillomavirus genotypes in heterosexual men after the australian female human papillomavirus vaccination programme: a retrospective observational study. | australia introduced a national quadrivalent human papillomavirus (4vhpv) vaccination programme for girls and young women in april, 2007. the hpv genotypes targeted by the female vaccine could also affect the protection afforded to heterosexual men. we examined the prevalence of 4vhpv targeted vaccine genotypes and the nine-valent hpv (9vhpv)-targeted vaccines genotypes among sexually active, predominantly unvaccinated heterosexual men from 2004 to 2015. | 2017 | 27282422 |
| human papillomavirus and chlamydia trachomatis infection in gyneco-obstetric outpatients from a mexican hospital. | human papillomavirus (hpv) and chlamydia trachomatis are the most frequent sexually transmitted infections, usually asymptomatic. persistent infection with high-risk hpv types and other cofactors such as the concomitant infection with c. trachomatis can represent a higher risk to develop cervical lesions; therefore, screening with sensitive methods could aid to identify women at risk. | 2017 | 28303822 |
| costing of national sti program implementation for the global sti control strategy for the health sector, 2016-2021. | in 2016 the world health assembly adopted the global strategy on sexually transmitted infections (sti) 2016-2021 aiming to reduce curable stis by 90% by 2030. we costed scaling-up priority interventions to coverage targets. | 2017 | 28129372 |
| the high-risk human papillomavirus e6 oncogene exacerbates the negative effect of tryptophan starvation on the development of chlamydia trachomatis. | chlamydia trachomatis is an obligate intracellular pathogen that requires specific essential nutrients from the host cell, one of which is the amino acid tryptophan. in this context interferon gamma (ifnγ) is the major host protective cytokine against chlamydial infections because it induces the expression of the host enzyme, indoleamine 2,3-dioxygenase 1, that degrades tryptophan, thereby restricting bacterial replication. the mechanism by which ifnγ acts has been dissected in vitro using epith ... | 2017 | 27658027 |
| frequency of chlamydia trachomatis infection in cervical intraepithelial lesions and the status of cytological p16/ki-67 dual-staining. | chlamydia trachomatis (ct) is not a disease subject to mandatory reporting in brazil, and the prevalence rate of this genital infection varies according to the region in which studies are conducted, as well as by the detection technique employed. ct has been associated with persistence of human papillomavirus (hpv) infection and the facilitation of cervical carcinoma development. we evaluated the chlamydia trachomatis infection and its association with cytology, p16/ki-67 dual-stained cytology a ... | 2017 | 28074107 |
| point-of-care sexually transmitted infection diagnostics: proceedings of the star sexually transmitted infection-clinical trial group programmatic meeting. | the goal of the point-of-care (poc) sexually transmitted infection (sti) diagnostics meeting was to review the state-of-the-art research and develop recommendations for the use of poc sti diagnostics. experts from academia, government, nonprofit, and industry discussed poc diagnostics for stis such as chlamydia trachomatis, human papillomavirus, neisseria gonorrhoeae, trichomonas vaginalis, and treponema pallidum. key objectives included a review of current and emerging technologies, clinical an ... | 2017 | 28282646 |
| immune reconstitution syndrome in a human immunodeficiency virus infected child due to giardiasis leading to shock. | human immunodeficiency virus (hiv)-associated immune reconstitution inflammatory syndrome has been reported in association with tuberculosis, herpes zoster (shingles), cryptococcus neoformans, kaposi's sarcoma, pneumocystis pneumonia, hepatitis b virus, hepatitis c virus, herpes simplex virus, histoplasma capsulatum, human papillomavirus, and cytomegalovirus. however, it has never been documented with giardiasis. we present a 7-year-old hiv infected girl who developed diarrhea and shock followin ... | 2017 | 26985424 |
| identification of novel 5,6-dimethoxyindan-1-one derivatives as antiviral agents. | discovery of novel antiviral agents is essential because viral infection continues to threaten human life globally. various heterocyclic small molecules have been developed as antiviral agents. the 5,6-dimethoxy indan-1-one nucleus is of considerable interest as this ring is the key constituent in a range of bioactive compounds, both naturally occurring and synthetic, and often of considerable complexity. | 2017 | 28359234 |
| potential role of e4 protein in human papillomavirus screening: a review | in 2006, cervical cancer was reported as the second most common cancer in women of malaysia. this type of cancer has been shown to correlate with persistent high risk human papillomavirus (hpv) infection. although hpv is well known to induce cervical cancer, knowledge of pathways that link the latent stage of the viral replication cycle to precancerous and cancerous stages remains incomplete. however, it is interesting to note that the virus can be isolated from tissues ranging from normal to lo ... | 2017 | 28345325 |
| high-risk human papilloma virus in archival tissues of oral pathosis and normal oral mucosa. | oral cancer ranks third among all cancers in the indian population. human papilloma virus (hpv) plays a significant role in oral carcinogenesis. population-based subtype variations are present in the hpv prevalence. this study gives an emphasis on the parameters to be considered in formalin fixed paraffin embedded tissues for polymerase chain reaction (pcr)-based research work. | 2017 | 26097346 |
| local action with global impact: highly similar infection patterns of human viruses and bacteriophages. | the investigation of host-pathogen interaction interfaces and their constituent factors is crucial for our understanding of an organism's pathogenesis. here, we explored the interactomes of hiv, hepatitis c virus, influenza a virus, human papillomavirus, herpes simplex virus, and vaccinia virus in a human host by analyzing the combined sets of virus targets and human genes that are required for viral infection. we also considered targets and required genes of bacteriophages lambda and t7 infecti ... | 2017 | 27822522 |
| the need to optimize adolescent immunization. | the adolescent period heralds the pediatric patient's transition into adulthood. it is a time of dynamic development during which effective preventive care measures can promote safe behaviors and the development of lifelong health habits. one of the foundations of preventive adolescent health care is timely vaccination, and every visit can be viewed as an opportunity to update and complete an adolescent's immunizations.in the past decade, the adolescent immunization schedule has expanded to incl ... | 2017 | 28167517 |
| stop codon mutagenesis for homogenous expression of human papillomavirus l1 protein in escherichia coli. | human papillomavirus (hpv) is widely accepted to be the major causative pathogen of cervical cancer, warts, and other epithelial tumors. virus infection and subsequent disease development can be prevented by vaccination with hpv vaccines derived from eukaryotic expression systems. here, we report the soluble expression of the major capsid protein l1 of hpv31, a dominant carcinogenic hpv genotype, in escherichia coli. hpv31 l1 protein and its elongated form (l1+) were observed in sds-page and ce- ... | 2017 | 28267627 |
| two-step chromatographic purification of glutathione s-transferase-tagged human papillomavirus type 16 e6 protein and its application for serology. | human papillomavirus (hpv) e6 protein is an oncoprotein with a pivotal role in cervical carcinogenesis. expression and purification of hpv e6 from escherichia coli (e. coli) has been difficult because of its strong hydrophobicity even when expressed as a fusion protein with glutathione s-transferase (gst). there has been no protocol suggested for purifying gst-tagged hpv e6 protein with high purity so far. herein, we provide efficient protocol for purifying gst-hpv16 e6 protein for the first tim ... | 2017 | 28089881 |
| expression, polyubiquitination, and therapeutic potential of recombinant e6e7 from hpv16 antigens fused to ubiquitin. | ubiquitin-proteasome system plays an essential role in the immune response due to its involvement in the antigen generation and presentation to cd8(+) t cells. hereby, ubiquitin fused to antigens has been explored as an immunotherapeutic strategy that requires the activation of cytotoxic t lymphocytes. here we propose to apply this ubiquitin fusion approach to a recombinant vaccine against human papillomavirus 16-infected cells. e6e7 multi-epitope antigen was fused genetically at its n- or c-ter ... | 2017 | 28025776 |
| in silico analysis of l1/l2 sequences of human papillomaviruses: implication for universal vaccine design. | the aim of this study was to design a multiepitope universal vaccine for major human papillomavirus (hpv) structural proteins, l1/l2, by bioinformatics models. for this purpose, we predicted the most probable immunogenic epitopes of l1 and l2 from common high-risk hpv 16, 18, 31, and 45 beside high prevalent type 6 and 11 based on bcpreds defaulted model, while solvent accessibility of structure was extrapolated. the three-dimensional molecular model of l1 protein was constructed by swiss model ... | 2017 | 28388355 |
| nucleic acid sensing with enzyme-dna binding protein conjugates cascade and simple dna nanostructures. | a versatile and universal dna sensing platform is presented based on enzyme-dna binding protein tags conjugates and simple dna nanostructures. two enzyme conjugates were thus prepared, with horseradish peroxidase linked to the dimeric single-chain bacteriophage cro repressor protein (hrp-sccro) and glucose oxidase linked to the dimeric headpiece domain of escherichia coli laci repressor protein (gox-dhp), and used in conjunction with a hybrid ssdna-dsdna detection probe. this probe served as a s ... | 2017 | 28331958 |
| secretory production of designed multipeptides displayed on a thermostable bacterial thioredoxin scaffold in pichia pastoris. | internal grafting of designed peptides to scaffold proteins is a valuable strategy for a variety of applications including recombinant peptide antigen construction. a peptide epitope from human papillomavirus (hpv) minor capsid protein l2 displayed on thioredoxin (trx) has been validated preclinically as a broadly protective and low-cost alternative hpv vaccine. focusing on thioredoxin from the hyperthermophilic archaebacterium pyrococcus furiosus (pftrx) as a scaffold, we have constructed a mod ... | 2017 | 27133916 |
| study of greek children and youths with cystic fibrosis identifies immunisation gaps and delays. | data about immunisation rates in cystic fibrosis (cf) patients are scarce. we estimated the rates and timeliness of immunisations in cf patients aged 0.55-22 years. | 2017 | 27862309 |
| modulation of pd-l1 and cd8 activity in idiopathic and infectious chronic inflammatory conditions. | programmed death-ligand 1 (pd-l1) can reduce the immune response by inhibiting cd8 t-cell proliferation and cytotoxic activity. we studied a series of human viral (molloscum, human papillomavirus, herpes simplex, cytomegalovirus, epstein-barr virus, smallpox) and bacterial infections (helicobacter pylori) for the in situ expression of pd-l1, mononuclear cell infiltration, and cd8 activity and compared this to noninfectious idiopathic inflammatory conditions to better define which immune response ... | 2017 | 27438510 |
| analyzing esophageal squamous cell papillomas for the presence of human papilloma virus. | human papilloma virus (hpv) infection can be a predisposing condition for the development of squamous cell papilloma (scp) of the esophagus, which can progress to dysplasia and to carcinoma as a result of chronic infection. the aim of the present study was to search for the presence of hpv in the esophageal scp, and to genotype the detected hpv. | 2017 | 28316321 |
| nitrative and oxidative dna damage in infection-related carcinogenesis in relation to cancer stem cells. | infection and chronic inflammation have been recognized as important factors for carcinogenesis. under inflammatory conditions, reactive oxygen species (ros) and reactive nitrogen species (rns) are generated from inflammatory and epithelial cells, and result in the formation of oxidative and nitrative dna lesions, such as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodg) and 8-nitroguanine. the dna damage can cause mutations and has been implicated in inflammation-mediated carcinogenesis. it has bee ... | 2017 | 28163802 |
| adjusted particle size eliminates the need of linkage of antigen and adjuvants for appropriated t cell responses in virus-like particle-based vaccines. | since the discovery of the first virus-like particle (vlp) derived from hepatitis b virus in 1980 (1), the field has expanded substantially. besides successful use of vlps as safe autologous virus-targeting vaccines, the powerful immunogenicity of vlps has been also harnessed to generate immune response against heterologous and even self-antigens (2-4). linking adjuvants to vlps displaying heterologous antigen ensures simultaneous delivery of all vaccine components to the same antigen-presenting ... | 2017 | 28321220 |
| characterization of the disassembly and reassembly of the hbv glycoprotein surface antigen, a pliable nanoparticle vaccine platform. | while nanoparticle vaccine technology is gaining interest due to the success of vaccines like those for the human papillomavirus that is based on viral capsid nanoparticles, little information is available on the disassembly and reassembly of viral surface glycoprotein-based nanoparticles. one such particle is the hepatitis b virus surface antigen (sag) that exists as nanoparticles. here we show, using biochemical analysis coupled with electron microscopy, that sag nanoparticle disassembly requi ... | 2017 | 28061386 |
| cervical human papillomavirus infection in the early postoperative period after liver transplantation: prevalence, risk factors, and concordance with anal infections. | solid organ transplant recipients are at increased risk of developing several human papillomavirus (hpv)-related malignancies, including cervical and anal cancers. the purpose of this prospective study was to assess the initial prevalence and risk factors for high-risk hpv (hr-hpv) cervical infections in liver transplant recipients, as well as their concordance with anal infections. a total of 50 female patients were enrolled in the department of general, transplant and liver surgery at the medi ... | 2017 | 27988990 |
| oncogenic role of tumor viruses in humans. | viruses are the intracellular pathogens that reproduce only in the living cell and manipulate the cellular machinery to produce more viruses. viral replications can affect cellular genes of the host in multiple cancerous ways. approximately, 20% of all human oncogenesis is caused by cancer-causing viruses known as oncoviruses. viral infection causes chronic inflammation leading to cell death, uncontrollable proliferation, and modulated expression of some of the regulatory proteins. oncogenesis i ... | 2017 | 27830995 |
| recent advancements in combination subunit vaccine development. | viral structural proteins share a common nature of homotypic interactions that drive viral capsid formation. this natural process has been mimicked in vitro through recombinant technology to generate various virus-like particles (vlps) and small subviral particles that exhibit similar structural and antigenic properties of their authentic viruses. therefore, such self-assembled, polyvalent, and highly immunogenic vlps and small subviral particles are excellent subunit vaccines against individual ... | 2017 | 27649319 |
| role of tlr9 in oncogenic virus-produced cancer. | nucleic acid recognition by toll-like receptor 9 (tlr9) initiates signaling pathways that regulate the production of proinflammatory cytokines or type i interferons, as well as many other molecules required to initialize the immune response. the use of synthetic oligodeoxynucleotides (odns) has been crucial to emulate the recognition of dna sequences by tlr9. furthermore, odn administration to mice has shown to confer protection against a wide range of viral, bacterial, and parasitic pathogens. ... | 2017 | 28151089 |
| gene editing: a new tool for viral disease. | the emergence of the crispr/cas system of antiviral adaptive immunity in bacteria as a facile system for gene editing in mammalian cells may well lead to gene editing becoming a novel treatment for a range of human diseases, especially those caused by deleterious germline mutations. another potential target for gene editing are dna viruses that cause chronic pathogenic diseases that cannot be cured by using currently available drugs. we review the current state of this field and discuss the pote ... | 2017 | 27576009 |
| using qualitative methods to develop a contextually tailored instrument: lessons learned. | to develop a population-specific instrument to inform hepatitis b virus (hbv) and human papilloma virus (hpv) prevention education and intervention based on data and evidence obtained from the targeted population of khmer mothers reflecting their socio-cultural and health behaviors. | 2017 | 27981114 |
| bizarre cell dysplasia of the cervix. | the aim of this study was the characterization of a new subtype of high-grade cervical squamous intraepithelial lesion (hsil) with enlarged cells containing bizarre nuclei: so-called bizarre cell dysplasia (bcd). | 2017 | 28150409 |
| the interaction between human papillomavirus and other viruses. | the etiological role of human papillomavirus (hpv) in anogenital tract and head and neck cancers is well established. however, only a low percentage of hpv-positive women develop cancer, indicating that hpv is necessary but not sufficient in carcinogenesis. several biological and environmental cofactors have been implicated in the development of hpv-associated carcinoma that include immune status, hormonal changes, parity, dietary habits, tobacco usage, and co-infection with other sexually trans ... | 2017 | 27826043 |
| prevalence of herpes simplex virus type 2 and risk factors associated with this infection in women in southern brazil. | the herpes simplex virus type 2 (hvs-2) is the most prevalent infection worldwide. it is a cofactor in the acquisition of human immunodeficiency virus (hiv) and the persistence of human papillomavirus (hpv). this study evaluated the prevalence of hsv-2, using the polymerase chain reaction (pcr), and associated factors in patients treated at the federal university of rio grande (furg) and basic health units (bhu) in rio grande, brazil. the observed prevalence of hsv-2 was 15.6%. among the 302 wom ... | 2017 | 24037285 |
| mzc gel inhibits shiv-rt and hsv-2 in macaque vaginal mucosa and shiv-rt in rectal mucosa. | the population council's microbicide gel mzc (also known as pc-1005) containing miv-150 and zinc acetate dihydrate (za) in carrageenan (cg) has shown promise as a broad-spectrum microbicide against hiv, herpes simplex virus (hsv), and human papillomavirus. previous data show antiviral activity against these viruses in cell-based assays, prevention of vaginal and rectal simian-human immunodeficiency virus reverse transcriptase (shiv-rt) infection, and reduction of vaginal hsv shedding in rhesus m ... | 2017 | 27552154 |
| the most important questions in cancer research and clinical oncology : question 1. could the vertical transmission of human papilloma virus (hpv) infection account for the cause, characteristics, and epidemiology of hpv-positive oropharyngeal carcinoma, non-smoking east asian female lung adenocarcinoma, and/or east asian triple-negative breast carcinoma? | specific research foci: (1) mouse models of gamma-herpes virus-68 (γhv-68) and polyomavirus (pyv) infections during neonatal versus adult life. (2) for human papilloma virus (hpv)-positive oropharyngeal carcinoma (opc)-(a) asking the question: is oral sex a powerful carcinogen? (b) examining the evidence for the vertical transmission of hpv infection. (c) examining the relationship between hpv and epstein-barr virus (ebv) infections and nasopharyngeal cancer (npc) in west european, east european ... | 2017 | 28093081 |
| cytomegalovirus and mucoepidermoid carcinoma: a possible causal relationship? a pilot study. | human cytomegalovirus (cmv) infection has tropism for salivary gland ductal epithelium and establishes a persistent and lifelong infection. mucoepidermoid carcinoma (mec) is the most common salivary gland tumor. recent studies have established that mouse cmv-induced tumorigenesis displays histologic and molecular characteristics similar to human mec. we wished to explore further down the lane by analyzing the expression of pp65 and the key oncogenic signaling pathway in cases of mec and their et ... | 2017 | 26980959 |
| virus-associated neoplasms of the nasopharynx and sinonasal tract: diagnostic problems. | a significant fraction of nasopharyngeal and sinonasal tumors are associated with epstein-barr virus (ebv) or human papillomavirus (hpv). nasopharyngeal carcinoma (npc) and extranodal nk/t-cell lymphoma harbor ebv in practically all cases, although a small proportion of cases of the former harbor hpv. sinonasal inverted papillomas harbor hpv in about 25% of cases. sinonasal squamous cell carcinomas harbor transcriptionally active hpv in about 20% of cases, and limited data suggest that this subs ... | 2017 | 28060369 |
| high levels of ebv-encoded rna 1 (eber1) trigger interferon and inflammation-related genes in keratinocytes expressing hpv16 e6/e7. | different types of cells infected with epstein-barr virus (ebv) can release exosomes containing viral components that functionally affect neighboring cells. previously, we found that ebv was localized mostly in infiltrating lymphocytes within the stromal layer of cervical lesions. in this study, we aimed to determine effects of exosome-transferred ebv-encoded rnas (ebers) on keratinocytes expressing human papillomavirus (hpv) 16 e6/e7 (donori-hpv16 hfks). lipid transfection of in vitro-transcrib ... | 2017 | 28056059 |
| smarcb1 (ini-1)-deficient sinonasal carcinoma: a series of 39 cases expanding the morphologic and clinicopathologic spectrum of a recently described entity. | to more fully characterize the clinical and pathologic spectrum of a recently described tumor entity of the sinonasal tract characterized by loss of nuclear expression of smarcb1 (ini1), we analyzed 39 smarcb1-deficient sinonasal carcinomas collected from multiple medical centers. the tumors affected 23 males and 16 females with an age range of 19 to 89 years (median, 52). all patients presented with locally advanced disease (t3, n=5; t4, n=27) involving the sinuses (mainly ethmoid) with variabl ... | 2017 | 28291122 |
| update from the 4th edition of the world health organization classification of head and neck tumours: what is new in the 2017 who blue book for tumors and tumor-like lesions of the neck and lymph nodes. | the world health organization (who) 2017 classification of head and neck tumors ("blue book") will now include a new chapter on tumors and tumor-like lesions of the neck and lymph nodes, which was not included in the previous edition. tumors and tumor-like lesions, including a variety of cysts and metastases, can arise in any component in the neck, including soft tissue, lymph nodes, and developmental remnants. the pathology and clinical features of metastatic carcinoma of unknown primary in the ... | 2017 | 28247228 |
| clinical value of the epstein-barr virus and p16 status in patients with nasopharyngeal carcinoma: a single-centre study in japan. | the clinical significance of the epstein-barr virus (ebv) status and p16 expression was unknown in nasopharyngeal carcinoma (npc). | 2017 | 28171876 |
| immunotherapy against cancer-related viruses. | approximately 12% of all cancers worldwide are associated with viral infections. to date, eight viruses have been shown to contribute to the development of human cancers, including epstein-barr virus (ebv), hepatitis b and c viruses, and human papilloma virus, among others. these dna and rna viruses produce oncogenic effects through distinct mechanisms. first, viruses may induce sustained disorders of host cell growth and survival through the genes they express, or may induce dna damage response ... | 2017 | 28008927 |
| (18) f-fdg pet/ct vs. human papillomavirus, p16 and epstein-barr virus detection in cervical metastatic lymph nodes for identifying primary tumors. | squamous cell carcinoma of unknown primary of the head and neck (sccup) is a heterogeneous disease entity that requires careful examination to locate the occult primary. we examined the diagnostic value of expression of biomarkers, such as human papillomavirus (hpv), p16 and epstein-barr virus (ebv), in metastatic lymph nodes vs. (18) f-fluorodeoxyglucose ((18) f-fdg) positron emission tomography/computed tomography (pet/ct). we prospectively enrolled 54 consecutive sccup patients who received h ... | 2017 | 27943271 |
| molecular concept in human oral cancer. | the incidence of oral cancer remains high in both asian and western countries. several risk factors associated with development of oral cancer are now well-known, including tobacco chewing, smoking, and alcohol consumption. cancerous risk factors may cause many genetic events through chromosomal alteration or mutations in genetic material and lead to progression and development of oral cancer through histological progress, carcinogenesis. oral squamous carcinogenesis is a multistep process in wh ... | 2017 | 26668446 |
| the influence of human papillomavirus on nasopharyngeal carcinoma in japan. | although japan is a non-endemic area with nasopharyngeal carcinoma (npc), the proportion of who type i npc in japan are different from that in non-endemic areas such as north america and europe. recently, it is said that not only epstein-barr virus (ebv) but also human papillomavirus (hpv) has an influence on npc in non-endemic areas. the aim of this study is to clarify the influence of hpv on npc in japan. | 2017 | 27499435 |
| the global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012. | by using data from the international agency for research on cancer publication cancer incidence in 5 continents and globocan, this report provides the first consolidated global estimation of the subsite distribution of new cases of lip, oral cavity, and pharyngeal cancers by country, sex, and age for the year 2012. major geographically based, sex-based, and age-based variations in the incidence of lip, oral cavity, and pharyngeal cancers by subsite were observed. lip cancers were highly frequent ... | 2017 | 28076666 |
| role of human papillomavirus and tumor suppressor genes in oral cancer. | the incidence of oral cancer remains high and is associated with many deaths in both western and asian countries. several risk factors for the development of oral cancer are now well known, including smoking, drinking and consumption of smokeless tobacco products. genetic predisposition to oral cancer has been found in certain cases, but its components are not yet entirely clear. in accordance with the multi-step theory of carcinogenesis, the natural history of oral cancer seems to gradually evo ... | 2017 | 27194871 |
| the prevalence of viral agents in esophageal adenocarcinoma and barrett's esophagus: a systematic review. | human papilloma virus (hpv), which may reach the esophagus through orogenital transmission, has been postulated to be associated with esophageal adenocarcinoma (eac). a systematic review of the literature investigating the prevalence of infectious agents in eac and barrett's esophagus (be) was carried out. | 2017 | 28252462 |
| the presence of human papillomavirus and epstein-barr virus in male chinese lichen sclerosus patients: a single center study. | this study aimed to investigate the presence of human papillomavirus and epstein-barr virus in male lichen sclerosus patients. we extracted dna from formalin-fixed paraffin-embedded foreskin tissue blocks of 47 male ls patients and 30 healthy men and performed real-time pcr test to detect hpv and ebv. none of the 47 ls patients and 30 healthy men had detectable hpv infection. ebv was detected in 18 ls patients (38.3%) and four healthy men (13.3%), the difference is significant (p < 0.05). tissue ... | 2017 | 26289401 |
| anal intraepithelial neoplasia: a review of diagnosis and management. | anal intraepithelial neoplasia (ain) is a premalignant lesion of the anal mucosa that is a precursor to anal cancer. although anal cancer is relatively uncommon, rates of this malignancy are steadily rising in the united states, and among certain high risk populations the incidence of anal cancer may exceed that of colon cancer. risk factors for ain and anal cancer consist of clinical factors and behaviors that are associated with the acquisition and persistence of human papilloma virus (hpv) in ... | 2017 | 28255426 |
| preliminary results of a screening program for anal cancer and its precursors for hiv-infected men who have sex with men in vigo-spain. | men who have sex with men (msm) infected with human immunodeficiency virus (hiv) have the highest risk of developing anal cancer (ac). the objective of this study was to describe our screening implementation program in this population, and report the prevalence of human papillomavirus (hpv) anal infection, and cytological and histological findings in a spanish medium-size community (vigo, spain). | 2017 | 28229612 |
| ano-genital warts and hiv status- a clinical study. | ano-genital warts (agw) like other sexually transmitted diseases (std) is associated with human immunodeficiency virus (hiv) infection. this study of agw was done in hiv positive and hiv negative patients. | 2017 | 28274028 |
| 2016 international meeting of the global virus network. | the global virus network (gvn) was established in 2011 in order to strengthen research and responses to current viral causes of human disease and to prepare against new viral pandemic threats. there are now 38 gvn centers of excellence and 6 affiliate laboratories in 24 countries. gvn scientists meet annually to learn about each other's current research, address collaborative priorities and plan future programs. the 2016 meeting was held from october 23-25 in hokkaido, japan, in partnership with ... | 2017 | 28315708 |
| human papilloma virus dermatosis in human immunodeficiency virus-positive patients: a 14-year retrospective study in 965 patients. | the incidence of the human papilloma virus (hpv) has not dropped in hiv-positive patients despite the discovery of antiretroviral therapy (art). our goal is to assess the prevalence of hpv in hiv patients and its relationship with the epidemiological and virological characteristics of hiv patients. | 2017 | 28238336 |
| a review of screening strategies for cervical cancer in human immunodeficiency virus-positive women in sub-saharan africa. | cervical cancer (cc) is a leading cause of cancer-related death and a major public health issue in sub-saharan africa. this heavy burden parallels that of the human immunodeficiency virus (hiv) infection, which increases the risk of developing cc. despite the progressive reduction of hiv prevalence in the past decade, the cc incidence and mortality rates in sub-saharan africa remain high. the heterogeneity of the distribution of the two diseases in the african continent, together with the differ ... | 2017 | 28203108 |
| multiple preinvasive and invasive hpv-related lesions of the anogenital tract in a female patient with hiv infection: a case report. | patients with human immunodeficiency virus (hiv) infection have been shown to be at increased risk for high-risk human papillomavirus (hr-hpv) infection of the anogenital tract. furthermore, in the last decades, the introduction of highly active antiretroviral therapy (haart) has increased the longevity of these patients who now live long enough to develop hpv-related cancers; hence, the impact of hpv infection on hiv-positive patients is of increasing concern. | 2017 | 28121939 |
| chinese shang ring male circumcision: a review. | chinese shang ring adult male circumcision (sc) is a safe and effective procedure which is easy to learn and to perform. by a specially designed small device, male circumcision (mc) can be performed in 5 min. compared with conventional adult mc (cc), sc has shorter operation time, less blood loss, less pain score, higher appearance satisfaction rate, and lower complication rate. sc was first developed in china. as recent studies have demonstrated that mc reduced the risk of acquiring human immun ... | 2017 | 28278508 |
| [comparison of human papilloma virus infection status between men who have sex with men recruited from gay bathhouses and hiv voluntary counseling and testing clinics respectively in urumqi]. | objective: to understand the human papilloma virus (hpv) infection status in men who have sex with men (msm) recruited from gay bathhouses and hiv voluntary counseling and testing (vct) clinics in urumqi, xinjiang uygur autonomous region, and identify the associated risk factors. methods: a total of 200 msm aged ≥18 years were recruited by using the " snowballing" sampling method from gay bathhouses and vct clinics in urumqi during march-may, 2016. the msm recruited completed questionnaires afte ... | 2017 | 28100377 |
| modeling the mechanisms by which hiv-associated immunosuppression influences hpv persistence at the oral mucosa. | human immunodeficiency virus (hiv)-infected patients are at an increased risk of co-infection with human papilloma virus (hpv), and subsequent malignancies such as oral cancer. to determine the role of hiv-associated immune suppression on hpv persistence and pathogenesis, and to investigate the mechanisms underlying the modulation of hpv infection and oral cancer by hiv, we developed a mathematical model of hiv/hpv co-infection. our model captures known immunological and molecular features such ... | 2017 | 28060843 |
| [sexuality risk factors among people with suspect of sexually transmitted disease]. | describing determinants factors in sexually transmitted diseases is necessary to evaluate and design effective measures for prevention and treatment. the aim of this research was to determine the sexual risk factors of people who are treated at sexually transmitted diseases centre and to analyze differences based on gender. | 2017 | 28117765 |
| cetuximab plus chemoradiotherapy for hiv-associated anal carcinoma: a phase ii aids malignancy consortium trial. | purpose squamous cell carcinoma of the anal canal (sccac) is characterized by high locoregional failure (lrf) rates after definitive chemoradiation (crt), associated with anogenital human papilloma virus, and often appears in hiv infection. because cetuximab enhances the effect of radiation therapy in human papilloma virus-associated oropharyngeal scc, we hypothesized that adding cetuximab to crt would reduce lrf in sccac. methods forty-five patients with stage i to iii sccac and hiv infection r ... | 2017 | 27937092 |
| sexually transmitted disease testing and uptake of human papillomavirus vaccine in a large online survey of us men who have sex with men at risk for hiv infection, 2012. | national guidelines recommend annual human immunodeficiency virus (hiv)/sexually transmitted disease testing for sexually active men who have sex with men (msm) and vaccination against human papillomavirus for msm through age 26. a 2012 online survey of 2,794 msm found that 51%, 36%, and 14% reported receiving human immunodeficiency virus testing, sexually transmitted disease testing, and human papillomavirus vaccination, respectively. | 2017 | 27898576 |
| hiv-associated anal dysplasia and anal carcinoma. | anal carcinoma shows an increasing incidence in people living with human immunodeficiency virus (hiv) and acquired immune deficiency syndrome (aids) in whom it is also much more common compared to the hiv-negative population. human papillomavirus infection is the etiological basis of malignant development in the anal epithelium. therefore, adequate diagnosis and treatment of the precursor lesions (anal intraepithelial neoplasia) is of clinical importance. in cases with preserved immune function, ... | 2017 | 28253522 |
| cervical cancer screening practices, knowledge of screening and risk, and highly active antiretroviral therapy adherence among women living with human immunodeficiency virus in lima, peru. | cervical cancer (cc) is the leading cause of cancer death among peruvian women. awareness shown by women living with hiv (wlhiv) of their increased risk and papanicoloau (pap) smear frequency is understudied, particularly in peru. we assessed the uptake of guidelines-based cc screening practices and its associations with two predictors, knowledge of cc screening and risk and highly active antiretroviral therapy (haart) adherence, among wlhiv. collected by self-administered questionnaires from 20 ... | 2017 | 27789849 |
| anal intraepithelial neoplasia. | anal squamous cell cancer (scc) is a relatively uncommon cancer in the united states. anal scc has long been associated with human immunodeficiency virus (hiv) positivity and/or men who have sex with men. the incidence of anal scc has been increasing in both genders regardless of hiv status. few clinicians are aware that white women, when not controlling for gender and sexual preference together, have the highest incidence of anal scc. anal intraepithelial neoplasia (ain), dysplastic cells of th ... | 2017 | 27749636 |
| anti-retroviral therapy's miracle in the treatment of bowen's disease in a human immunodeficiency virus-positive patient: a rare case report. | bowen's disease (bd) is a form of squamous cell carcinoma in situ often associated with human papillomavirus. co-infection with human immunodeficiency virus (hiv) is associated with a greater risk of malignancy. we describe a case of bd in a 52-year-old unmarried hiv-positive male who presented with extensive skin lesions of 1-year duration. histopathology was suggestive of bd. he had been tried with topical imiquimod cream and cryo-therapy for 6 months. we observed no response for these above t ... | 2017 | 27890959 |
| high rates of anal high-grade squamous intraepithelial lesions in hiv-infected women who do not meet screening guidelines. | human immunodeficiency virus (hiv)-infected women have a higher burden of anal high-grade squamous intraepithelial lesions (hsil) and anal cancer (ac) compared with hiv-uninfected women. guidelines for ac screening in this population are heterogeneous. here we report outcomes and risk factors for anal hsil following implementation of universal ac screening offered to all hiv-infected women. | 2017 | 27965301 |
| efficacy of a film-forming medical device containing piroxicam and sun filters in the treatment of multiple actinic keratosis lesions in a subject with a history of kaposi sarcoma. | actinic keratosis (ak) is considered a premalignant form of skin cancer due to chronic sun exposure. in addition, human papilloma virus (hpv) has been advocated a role in the pathogenesis of this clinical condition. hpv proteins (mainly e6 and e7) seem to act synergistically with ultraviolet (uv) radiation in reducing the defensive mechanisms of keratinocyte apoptosis after uv damage. data regarding the involvement of other viruses, i.e. human herpes viruses (hhv), in the pathogenesis of ak are ... | 2017 | 28101017 |
| human immunodeficiency virus/aids, human papillomavirus, and anal cancer. | anal cancer is an increasingly common non-aids-defining cancer among individuals infected with the human immunodeficiency virus (hiv). it is associated with human papillomavirus (hpv). hpv16 is the most common genotype detected in anal cancers. the hpv types detected in anal cancer are included in the 9-valent vaccine. hpv vaccines have demonstrated efficacy in reducing anal precancerous lesions in hiv-infected individuals. standard treatment has been fluorouracil and mitomycin (or cisplatin) pl ... | 2017 | 27889034 |
| adult immunization-need of the hour. | immunization is the process or the act of making individuals immune, which is usually done during childhood. everyone is aware about immunization during childhood, however, very few know about adult immunization. this led us to review the adult immunization literature for the preventive strategies through various vaccination protocols. adults do require vaccination protocols with booster doses for hepatitis b, shingles, communicable diseases, traveler's diseases, etc. in this context, this artic ... | 2017 | 27583212 |
| evaluation of cervical and anal intraepithelial neoplasia in women attending a sexually transmitted infection clinic. | the incidence of anal and cervical cancers and their precursors have increased in the past decades. women with hiv and sexually transmitted infections are at a higher risk. cervical human papilloma virus infection may serve as a reservoir and source of anal infection or vice versa. a higher incidence of anal cytological abnormality has been observed in patients with abnormal cervical cytology. | 2017 | 27297278 |
| [effectiveness of human papillomavirus genotyping for detection of high-grade anal intraepithelial neoplasia compared to anal cytology]. | the incidence of high-grade anal intraepithelial neoplasia (hgain) -with an aetiological based on high-risk types of human papillomavirus- is increasing in some high-risk groups. screening for hgain includes routine anal cytology and, more recently, hpv genotyping. the main objective of this study was to determine the sensitivity and specificity of anal cytology and hpv genotyping for the detection of hgain. | 2017 | 26976378 |
| human papilloma virus infection and psoriasis: did human papilloma virus infection trigger psoriasis? | psoriasis is an autoimmune chronic inflammatory skin disease known to be triggered by streptococcal and hiv infections. however, human papilloma virus infection (hpv) as a triggering factor for the development of psoriasis has not been reported yet. we, hereby report a case of plaque type with inverse psoriasis which probably could have been triggered by genital warts (hpv infection) and discuss the possible pathomechanisms for their coexistence and its management. | 2017 | 26692619 |
| effect of antiretroviral therapy on mucocutaneous manifestations among human immunodeficiency virus-infected patients in a tertiary care centre in south india. | human immunodeficiency virus (hiv) infection produces a wide range of infectious and noninfectious dermatoses which correlate with the degree of immunodeficiency. since the introduction of highly active antiretroviral therapy (haart), there has been a dramatic decrease in the incidence of hiv-associated dermatoses. however, haart itself causes various cutaneous adverse drug reactions. | 2017 | 26692610 |
| an interesting finding in the uterine cervix: schistosoma hematobium calcified eggs. | schistosoma hematobium infection is an endemic parasitic disease in africa, which is frequently associated with urinary schistosomiasis. the parasite infection causes epithelial changes and disruption, facilitating the infection by the human papilloma virus and human immunodeficiency virus (hiv). the authors report the case of a 44-year-old african hiv-positive woman who presented an abnormal routine pap smear. colposcopy examination revealed dense acetowhite micropapillary epithelium covering t ... | 2017 | 26484333 |
| human papilloma virus and cervical cancer education needs among hiv-positive haitian women in miami. | haitian immigrant women, the largest growing black ethnic group in miami, experience the highest rates of cervical cancer and account for one of the largest populations diagnosed with human immunodeficiency virus/acquired immunodeficiency syndrome (hiv/aids) in south florida. using community-based participatory research methods, we conducted a pilot study to examine human papilloma virus (hpv)/cervical cancer knowledge and identify intervention preferences among hiv positive haitian women. | 2017 | 25864021 |
| enhanced efficacy with reduced toxicity of chemotherapy drug 5-fluorouracil by synergistic treatment with abnormal savda munziq from uyghur medicine. | abnormal savda munziq (asmq) is a traditional prescription in uyghur medicine, and its treatment of complex diseases such as tumors and asthma has been proven to be effective in uyghur medical clinical practice. the efficacy-enhancing and toxicity-reducing properties of asmq were studied on mice with transplanted cervical cancer (u27) tumors, which were treated with 5-fluorouracil (5-fu) in this work. | 2017 | 28388901 |
| unique dna methylation signature in hpv-positive head and neck squamous cell carcinomas. | head and neck squamous cell carcinomas (hnsccs) represent a heterogeneous group of cancers for which human papilloma virus (hpv) infection is an emerging risk factor. previous studies showed promoter hypermethylation in hpv(+) oropharyngeal cancers, but only few consistent target genes have been so far described, and the evidence of a functional impact on gene expression is still limited. | 2017 | 28381277 |
| gene promoter methylation and protein expression of brms1 in uterine cervix in relation to high-risk human papilloma virus infection and cancer. | cervical cancer is strongly related to certain high-risk types of human papilloma virus infection. breast cancer metastasis suppressor 1 (brms1) is a tumor suppressor gene, its expression being regulated by dna promoter methylation in several types of cancers. this study aims to evaluate the methylation status of brms1 promoter in relation to high-risk types of human papilloma virus infection and the development of pre-cancerous lesions and describe the pattern of brms1 protein expression in nor ... | 2017 | 28381193 |
| retrospective study of the influence of hpv persistence on outcomes among women with high-risk hpv infections and negative cytology. | to evaluate the outcomes of women diagnosed with high-risk hpv without cytology evidence of cervical dysplasia. | 2017 | 28388819 |
| hpv-negative penile squamous cell carcinoma: disruptive mutations in the tp53 gene are common. | the majority of penile squamous cell carcinomas is caused by transforming human papilloma virus (hpv) infection. the etiology of hpv-negative cancers is unclear, but tp53 mutations have been implicated. archival tissues of 108 invasive squamous cell carcinoma from a single pathology institution in a low-incidence area were analyzed for hpv-dna and p16(ink4a) overexpression and for tp53 mutations by ion torrent next-generation sequencing. library preparation failed in 32/108 squamous cell carcino ... | 2017 | 28387325 |
| hpv testing in first-void urine provides sensitivity for cin2+ detection comparable to a physician-taken smear or brush-based self-sample: cross-sectional data from a triage population. | to compare sensitivity of high-risk hpv (hrhpv) and genotype detection in self-collected morning (u1) and later (u2) urine samples, brush-based self-samples (ss) and physician-taken smears (pts) for detecting cin2+ in a colposcopic referral population. | 2017 | 28391609 |
| generalized verrucosis and abnormal t cell activation due to homozygous taok2 mutation. | generalized verrucosis (gv) is a chronic and progressive cutaneous human papillomavirus (hpv) infection resulting in multiple warts and associated with acquired or genetic immune defects. we identified a consanguineous arab family manifesting gv and recurrent bacterial and viral infections, in association with inflammatory bowel disease (ibd). | 2017 | 28385331 |
| decline in hospitalization for genital warts in the veneto region after an hpv vaccination program: an observational study. | human papillomavirus (hpv) is one of the most common sexually transmitted pathogens. this observational study was conducted to estimate the trend of hospitalization for genital warts (gws) in the veneto region (italy) from 2004 to 2015. | 2017 | 28381294 |
| immunisation coverage annual report, 2014. | this 8th annual immunisation coverage report shows data for 2014 derived from the australian childhood immunisation register and the national human papillomavirus vaccination program register. this report includes coverage data for 'fully immunised' and by individual vaccines at standard age milestones and timeliness of receipt at earlier ages according to indigenous status. overall, 'fully immunised' coverage has been mostly stable at the 12- and 24-month age milestones since late 2003, but at ... | 2017 | 28385140 |
| effectiveness of photodynamic therapy in elimination of hpv-16 and hpv-18 associated with cin i in mexican women. | the present study aimed to determine the effectiveness of photodynamic therapy (pdt), using δ-aminolevulinic acid (5-ala), in the elimination of premalignant cervical lesions in mexican patients with human papillomavirus (hpv) infection and/or cervical intraepithelial neoplasia (cin). thirty women diagnosed with cin i and/or positive for hpv participated in the study. topical 6% 5-ala in gel form was applied to the uterine cervix; after 4 h, the lesion area was irradiated with a light dose of 20 ... | 2017 | 28380684 |
| quantitative multiplex immunohistochemistry reveals myeloid-inflamed tumor-immune complexity associated with poor prognosis. | here, we describe a multiplexed immunohistochemical platform with computational image processing workflows, including image cytometry, enabling simultaneous evaluation of 12 biomarkers in one formalin-fixed paraffin-embedded tissue section. to validate this platform, we used tissue microarrays containing 38 archival head and neck squamous cell carcinomas and revealed differential immune profiles based on lymphoid and myeloid cell densities, correlating with human papilloma virus status and progn ... | 2017 | 28380359 |
| surepath specimens versus thinprep specimen types on the cobas 4800 platform: high-risk hpv status and cytology correlation in an ethnically diverse bronx population. | to compare the cytologic preparations of 130 cervical specimens (from women of various ethnicities at high risk for human papillomavirus [hpv] infection) using the surepath (sp) collection system with specimens gathered using the thinprep (tp) system, as processed on the cobas 4800 analyzer, to determine which collection method more accurately identifies hpv infection. | 2017 | 28379422 |
| using a patient navigator to improve postpartum care in an urban women's health clinic. | to estimate whether postpartum visit attendance was improved in women exposed to a postpartum patient navigation program compared with those who received care immediately before the program's initiation and to assess whether other postpartum health behaviors improved during the intervention period. | 2017 | 28383374 |
| genetic mutation and exosome signature of human papilloma virus associated oropharyngeal cancer. | human papilloma virus-16 (hpv-16) associated oropharyngeal cancer (hpvopc) is increasing alarmingly in the united states. we performed whole genome sequencing of a 44 year old, male hpvopc subject diagnosed with moderately differentiated tonsillar carcinoma. we identified new somatic mutation in muc16 (a.k.a. ca-125), muc12, muc4, muc6, muc2, sirpa, hla-drb1, hla-a and hla-b molecules. increased protein expression of muc16, sirpa and decreased expression of hla-drb1 was further demonstrated in t ... | 2017 | 28383029 |