Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [magnius' e-antigen]. | the "e" ag/ac system found by magnius in 1972 is discussed briefly. the new antigen has the same immologic and physiochemical characteristics of hbs and hbc of the hepatitis virus. its existence shows the chronic evolution of the disease in ag hbs carriers. therefore the "e" antigen has a prognostic value in ag hbs carries. | 1977 | 329074 |
| correlation between titer of antibody to hepatitis b core antigen and presence of viral antigens in the liver. | liver specimens of 31 autopsied cases of liver cirrhosis who had had detectable levels of antibody to hepatitis b core antigen (anti-hbc) inthe serum were stained for hepatitis b core antigen (hbcag) and hepatitis b surface antigen (hbsag) by the direct immunofluorescence method. their premortem serum samples were tested for hbsag, antibody to hbsag (anti-hbs) and anti-hbc. persistent hepatitis b virus (hbv) infection as judged by circulating and/or liver hb antigens was identified in 18 patien ... | 1977 | 330306 |
| eukaryotic dna polymerases. | 1977 | 332062 | |
| immune response to hepatitis b virus in children with papular acrodermatitis. | papular acrodermatitis of childhood (pac) is characterized by papular eruption of skin, lymphadenopathy, and acute hepatitis b surface antigen (hbsag)-positive anicteric hepatitis. to study the course of hepatitis b virus infection we followed 16 patients with pac, 2 to 7 years of age, for periods ranging from 6 to 46 months. all patients tested developed hepatitis b surface antigenemia subtype ay, and produced antibody to hepatitis b core antigen with the highest incidence after 3 to 5 months. ... | 1977 | 332578 |
| simultaneous presence of hbsag and anti-hbs in the serum of different subtypes (serological and immunofluorescent studies). | serological and immunofluorescent studies were performed in 3 patients with the simultaneous presence of hbsag and anti-hbs in the serum. our investigations revealed the following results: hbsag and anti-hbs in the serum were of different subtypes. hbsag in the serum and in the liver had the same subtype. hbsag in the liver did not react with the circulating anti-hbs in the patient's own serum. hbsag-anti-hbs immune complexes could not be detected in the serum or in the liver tissue. these pheno ... | 1977 | 333803 |
| hepatitis b in ward and clinical laboratory employees of a general hospital. | after a sharp increase in viral hepatitis cases, mostly type b, among the 2000 employees of a general hospital during three years, we conducted an investigation which consisted of obtaining data on employee cases and surveying many current employees. of the 38 cases, 22 occurred in non-physician, ward employees. of 189 current ward employees, 8% had antibody to hepatitis b surface antigen (anti-hbs) and 1% had hepatitis b surface antigen (hbsag). hepatitis b virus (hbv) seropositivity was highes ... | 1977 | 333905 |
| the genome of hepatitis b virus. | 1977 | 334041 | |
| enzyme immunoassay for hepatitis b and its comparison to other methods. | a solid-phase enzyme immunoassay for the qualitative detection of hepatitis b surface antigenemia is presented and the results compared to the counter-immunoelectrophoresis and radioimmunoassay methods for detection of the same antigen. the enzyme-antibody conjugate was prepared from horseradish peroxidase coupled with antibodies to three sub-types of hepatitis b virus. polystyrene plastic tubes were used as the solid-phase support. the results of the enzyme immunoassay compare favorably with ra ... | 1977 | 336244 |
| [comparison between the presence of specific circulating immune complexes and the leukocyte migration inhibition test in different clinical forms of hepatitis b]. | circulating immune complexes were measured by a radioimmunoassay specific for hb complexes in different clinical situations related to hepatitis b virus infection. the leukocyte migration inhibition test (lmit) was performed simultaneously. comparison with the clinical situation suggests that immune complexes are not responsible for the lesions, but that these lesions might be produced by the immunity demonstrated by the lmit. a deficiency of this immunity is responsible for the persistence of i ... | 1977 | 337469 |
| the outcome of hepatitis b virus infection in pregnancy. | the literature concerning hepatitis b in pregnancy is reviewed and problems of management of both the acute and chronic infections are discussed. | 1977 | 339213 |
| hepatitis viruses. | 1978 | 340799 | |
| [maternal transmission of the hepatitis b virus (incidence and results)]. | 1977 | 342329 | |
| localisation of e-antigen in nuclei of hepatocytes in hbsag-positive liver diseases. | by the direct immunofluorescence technique 19 liver biopsies were examined for the presence of the e-antigen associated with the hepatitis b virus infection. with the use of double incubation and blocking experiments with fitc and rhodamine labelled antisera against hepatitis b core antigen and e-antigen, evidence is presented that the e-antigen is localised in the nuclei of the hepatocytes. we conclude that the e-antigen and the core antigen are not identical, although they are often present si ... | 1977 | 342357 |
| humoral and cell-mediated immunity to hepatitis b virus antigen in a haemodialysis-renal transplantation unit. | hepatitis b surface antigen (hbsag), the corresponding antibody (anti-hbs), the antibody to hepatitis b core antigen (anti-hbc), and the cellular immune response to purified hbsag (leucocyte migration inhibition test: lmt-hbsag) were determined in 19 staff members, 11 long-term haemodialysis patients, and 22 renal transplant patients in a haemodialysis-renal transplantation unit. past or present infection, as expressed by the presence of circulating anti-hbs or hbsag, was found in 30 cases (58 p ... | 1977 | 343497 |
| hepatitis b. cytologic localization of virus antigens and the role of the immune response. | antigens of the hepatitis b virus have been localized within liver tissue by various immunologic, histochemical, and electron microscopic methods. the abundance and distribution of these virus antigens are in part determined by the host immune response. this interaction of immune mechanisms with the hepatitis b virus may be related to the pathogenesis and natural history of human hepatitis b virus infection. | 1978 | 344193 |
| [the selection and surveillance of cadaver kidney recipients. recent development in graft immunology (author's transl)]. | this study, based on results of 252 cadaver kidney transplantations, shows that some factors which reflect individual immune response capacity, such as ability to produce anti-hla antibodies, sex and response to hepatitis b virus, appear, along with hla compatibility, to markedly influence renal graft survival and leads us to propose the following new guide-line for cadaver kidney recipient selection: for "good responders" (i.e., patients with anti-hla antibodies, females and hbs ag negative ind ... | 1978 | 345239 |
| [pathology of hepatitis and liver cirrhosis in idiopathic cryoglobulinemic syndromes. clinical, casuistic and histopathological contribution]. | 1978 | 347545 | |
| asymptomatic structural liver disease in hemophilia. | in a study of persistent abnormalities of liver-function tests in hemophilic patients deficient in factor viii or ix and treated with factor viii or ix concentrates, we examined 14 liver biopsies from 13 anti-hbs-positive patients. none had any symptoms of liver disease. all had chronically abnormal levels of alanine aminotransferase. histologic studies showed chronic persistent hepatitis in eight patients, chronic active hepatitis in four and fatty infiltration with portal fibrosis in one. indi ... | 1978 | 349386 |
| urticaria associated with acute viral hepatitis type b: studies of pathogenesis. | to determine whether skin deposition of circulating immune complexes contributes to prodromal urticaria of acute hepatitis b, we studied two patients with hepatitis b who presented with urticaria and fever. during the urticarial prodrome but not thereafter, we found activation of both classic and alternative complement pathways. hepatitis b surface antigen (hbsag)-antibody complexes were identified (by electron microscopy) in cryoprecipitates from both patients and igg (by immunodiffusion) in cr ... | 1978 | 352219 |
| immune mechanisms and the action of interferon in chronic hepatitis b virus infection. | cytotoxic t lymphocytes can eliminate cells infected with hepatitis b virus. a defect of t lymphocyte-mediated cytolysis seems to exist in chronic hepatitis b infection. t cell-mediated lysis is dependent on hla antigens of the infected host and this may explain the increased or decreased frequency of particular hla antigens in chronic carriers of hepatitis b virus. this virus may decrease the concentration of hla antigens expressed on liver cells. interferon increases the hla antigen expression ... | 1978 | 352919 |
| liver biopsy in chronic hepatitis: 1968-78. | the classification of chronic hepatitis introduced in 1968 is still current, but has been modified. the concept of bridging hepatic necrosis has been incorporated, and is recognised as an important feature of both acute and chronic aggressive (active) hepatitis (cah). in the pathogenesis of the latter, piecemeal necrosis is, however, thought to be the more important factor. the histological picture of cah varies widely. several causes of cah have been identified, including hepatitis b virus. rec ... | 1978 | 355068 |
| fluorescent antibody study of diseased, end-stage human kidneys. | forty cases of diseased kidneys at end-stage were studied by fluorescent antibody technique in search for viral etiology of glomerulonephritis and other renal diseases. among these 40 cases, 12 (30%) were ascribed to immune complex disease because of detection of immunoglobulins and complement in glomeruli of the same kidney specimen. in 8 cases (20%) only complement was detected in glomeruli. in the remaining 50% neither complement nor immunoglobulin deposit was found in glomeruli. the etiologi ... | 1977 | 357100 |
| [antigenic e system in hepatitis b virus-induced infection]. | 1978 | 358161 | |
| drug therapy reviews: chronic hepatitis. | the classification, clinical course, etiology and treatment of chronic hepatitis are discussed. the clinical manifestations of chronic hepatitis are of limited diagnostic use. diagnosis must be made by liver biopsy. the disease is classified as chronic persistent or chronic active hepatitis. the prognosis for chronic persistent hepatitis is excellent, and no treatment is required. chronic active hepatitis may progress to cirrhosis and is associated with a poor prognosis if untreated. recognized ... | 1978 | 358829 |
| "e" antigen: what is it? | 1978 | 362538 | |
| [morphologic and biophysical study of serum hepatitis transfection]. | 1978 | 366901 | |
| e antigen in the serum of hbs antigen-positive patients on maintenance dialysis and after transplantation. | the 'e antigen' (eag) is specifically associated with hepatitis b virus infections and appears to be a marker for the infectivity and a prognostic indicator of the chronicity of liver disease. therefore we examined by immunodiffusion the presence of eag in the seum of hbsag-positive patients on maintenance dialysis. the dialysis patients had a significantly higher incidence of positive eag compared with a group of unselected hbsag-positive patients without renal failure. in most of the dialysis ... | 1978 | 368777 |
| [hepatitis b virus (hbv) (author's transl)]. | 1978 | 369117 | |
| [development of a system for determining antibodies to the surface antigen of the virus of hepatitis b (hbsab)]. | a method for preparation of an immune diagnosticum using human erythrocytes of 0 (i) blood group sensitized with hepatitis b surface antigen in the presence of chromium chloride followed by the addition of formalin solution, for detection of antibody to the hepatitis b surface antigen is described. using this immune diagnosticum, antibody to the surface antigen of hepatitis b virus was detected in 12-15% of the normal population in the latvian ssr, and in 91% of patients with hepatitis b. | 1979 | 369142 |
| free "small" and igg-associated "large" hepatitis b e antigen in the serum and glomerular capillary walls of two patients with membranous glomerulonephritis. | nephrotic syndrome developed in two children who carried hepatitis b virus. both their serums contained hepatitis b surface antigen and hepatitis b e antigen (hbeag). two physicochemically and immunologically different categories of hbeag activity were identified in their serums--i.e., small molecular (free) and large molecular (associated with igg). their kidney-biopsy specimens disclosed pathologic changes typical of membranous glomerulonephritis. by a fluorescent-antibody technic, hbeag was ... | 1979 | 370592 |
| demonstration of hepatitis b e antigen in hepatitis b core particles obtained from the nucleus of hepatocytes infected with hepatitis b virus. | liver tissue infected with hepatitis b virus was homogenized and nuclei were separated by centrifugation. hepatitis b core particles were obtained from the nucleus by the digestion with pronase followed by ultracentrifugation in a sucrose density gradient. hepatitis b core particles were then treated with sodium dodecyl sulphate and 2 mercaptoethanol and tested for hepatitis b e antigen (hbeag) by the haemagglutination method. the antigenicity of hbeag was clearly demonstrated in hepatitis b cor ... | 1979 | 372495 |
| vaccines being tested for therapy, prevention of lung and liver cancer. | 1979 | 372606 | |
| hepatitis b virus markers among family contacts of asymptomatic hbsag carriers. | a study was undertaken to establish the risk of family contacts of hbsag carriers acquiring a hepatitis b virus (hbv) infection. about one-third of all household contacts of asymptomatic hbsag carriers had signs of past or ongoing hbv infection. family contacts of hbsag carriers with high numbers of circulating dane particles were shown to have a higher risk of developing hbv infection than family contacts of hbsag carriers without serological evidence of hbv synthesis. the probability of acquir ... | 1979 | 375378 |
| relationship between membrane-bound immunoglobulin and viral antigens in liver cells from patients with hepatitis b virus infection. | in an attempt to define further the significance of immunoglobulin g (igg) fixed in vivo to the hepatocyte membrane in hepatitis b virus (hbv) infection, we have studied the relationship between presence of membrane-bound igg and that of intracellular hepatitis b surface (hbsag) and core (hbcag) antigens in hepatocytes from 25 hbsag chronic carriers. for this purpose, we have used a double immunofluorescence technique that is able to detect igg and viral antigens within the same liver cell. in 1 ... | 1979 | 376391 |
| expression in escherichia coli of hepatitis b virus dna sequences cloned in plasmid pbr322. | fragments of hepatitis b virus dna isolated from dane particles have been inserted into the escherichia coli plasmid pbr322 and cloned. cells carrying the hybrid plasmid synthesise antigenic material that reacts specifically with antisera to hepatitis b viral antigens. | 1979 | 377093 |
| [recent advances in the study of viral hepatitis]. | 1979 | 377218 | |
| cloning in escherichia coli and physical structure of hepatitis b virion dna. | a restriction map of hepatitis b virion dna was established after cloning of the whole viral genome in escherichia coli. by use of ecori, xho i, bgl ii, xba i, bamhi, hincii, and hae iii endonucleases, a total of 28 restriction sites were mapped. the single-stranded region was localized on the restriction map and 5' end of the short strand was mapped at a fixed position. | 1979 | 377294 |
| graft survival and response to hepatitis-b virus in kidney recipients. | 1979 | 377722 | |
| the etiology of chronic active hepatitis in korea. | in a study of apparently normal, healthy korean army recruits performed in 1962, we found that 42 of 1,906 screened subjects had elevations of their serum glutamic pyruvate transaminase. liver biopsies were obtained from 32 of these subjects and 9 of these had a "novel" antigen present, which reacted specifically with a convalescent serum from a case of serum hepatitis. we have recently tested frozen serum obtained from 8/9 of these cases and found that all 8 had hbsag in their serum which, in s ... | 1979 | 377825 |
| hepatitis b core antigen immune complexes in the liver of hepatitis b patients. | single liver biopsies from 102 clinically diagnosed hepatitis patients were examined by immunofluorescence for the presence of hepatitis b surface antigen (hbsag) and hepatitis b core antigen (hbcag), complement and immunoglobulin deposition, and for their capacity to fix human complement in vitro. of the sixty-five hbsag positive livers, fifty-three were histologically diagnosed as chronic hepatitis, three as acute hepatitis, five as acute hepatitis with signs of transition to chronicity, and f ... | 1979 | 385186 |
| [markers of type b viral hepatitis]. | the discovery of australian antigen (hbsag) has led to an increasing deal of knowledges about the virus of type b hepatitis (hbv); several markers of hbv have been detected and are becoming disposable for clinical and epidemiological purposes. the hbsag is carried by 3 types of particulate structures discovered by electron microscopy as small spherical particles having diameter around 22 nm, long filaments and spherical particles having an overall diameter of the 42 nm (dane-particle) with an el ... | 1979 | 386166 |
| the occurrence of antibody markers of hepatitis b virus infection in an hbsag-negative blood donor population. | anti hbs, anti-hbc and anti-hbe were tested in blood donors negative for hbsag by radio- and enzyme-immunoassay. in this population 6.4% of the donors were positive for at least one type of antibody to hbv: 4.0% for anti-hbs, 2.3% for anti-hbc and 4.3% for anti-hbe. two sera (0.2%) were exclusively positive for anti-hbc, eight sera (2.2%) were weakly positive only for anti-hbe. further studies of the infectivity of such samples might be of interest. | 1979 | 386609 |
| hepatitis b virus infection in a renal unit in india. | 1979 | 387581 | |
| expression of hbsag on the membrane of hepatocytes in chronic carriers of hepatitis b virus infection. | liver cell membrane localization of hepatitis b surface antigen (hbsag) was investigated in 31 asymptomatic chronic carriers by a direct immunofluorescence technique. a close relationship was found between absence of inflammatory liver disease, presence of large amounts of hbsag in the liver and expression of the antigen at the hepatocyte surface. capping of hbsag after the addition of anti-hbs serum could be inhibited by factors (temperature, metabolic inhibition) that are known to influence vi ... | 1978 | 387960 |
| [transfer factor (tf) treatment of patients with hbs-ag-positive chronic active hepatitis. a prospective, controlled study (author's transl)]. | it is a clinically and experimentally well supported working hypothesis that infection with hepatitis b virus may result in chronic active hepatitis in patients with suspected immune deficiencies. on this basis, a pilot study was performed in order to evaluate the effect of "specific" transfer factor (tf) in the treatment of hbs-ag-positive chronic active hepatitis. from the leukocytes of 500 ml venous blood each of 40 volunteers that had completely recovered from acute virus hepatitis b within ... | 1979 | 388053 |
| sex differences in response to hepatitis b virus. iii. responses to hbv and sex of donor and recipient in kidney and bone marrow transplantation. | we proposed the hypothesis that there is an antigen on the hepatitis b virus (hbv) that cross-reacts with a male associated antigen to explain four observations: 1) sex differences in the responses to hbv infection, 2) sex differences in the prevalence of chronic liver diseases associated with hepatitis b, 3) the association of parental responses to hbv with the sex ratio (at birth) of their offspring, and 4) the relation of kidney graft survival with the combination of anti-hbs in the recipient ... | 1979 | 389250 |
| refugees will be screened for hepatitis b virus. | 1979 | 389394 | |
| [chronic hepatitis b. relationships between hepatitis virus and immunological response]. | 1979 | 390421 | |
| [hepatitis virus b infection and hepatopathy after kidney transplantation]. | serological markers for hepatitis virus b (hbv) infection and the occurrence of hepatopathies were analyzed in 152 patients during the hemodialysis period and on average 3.8 years after receiving a renal allotransplant. at the beginning of hemodialysis, 25% of the patients showed signs of an ongoing or past infection with hbv (10% hepatitis virus b surface-antigen [hbsag] positive and 15% anti-hbsag positive). at the time of transplantation, 20% of the patients were positive for hbsag and 25% ha ... | 1979 | 390693 |
| hepatitis b-associated membranous glomerulonephritis in a child. | this appears to be the first reported case of membranous glomerulonephritis in a pediatric asymptomatic carrier of hepatitis b virus in north america. routine immunofluorescent methods were used to identify the hepatitis b surface antigen in glomeruli. in addition, the glomerular immune deposits were searched for the known ultrastructural forms of the virus. | 1979 | 391021 |
| an ultrastructural and immunohistochemical study on the delta antigen associated with the hepatitis b virus. | thirteen liver biopsies in which the delta antigen was detected by immunofluorescence were studied by electron microscopy and immune electron microscopy with peroxidase labelled igg and f(ab1)2 fraction obtained from a human antiserum containing high-titre anti-delta antibodies. the findings were compared with those obtained in 11 hbcag positive and in two hbsag negative controls. neither unique particulate morphology nor any hb virus ultrastructural component were visualised in the delta positi ... | 1979 | 392063 |
| [modern view on etiology and prevention of hepatitis b virus infection with regard to their place in dentistry]. | 1978 | 392610 | |
| selective detection of igm-antibody against core antigen of the hepatitis b virus by a modified enzyme immune assay. | igm antibody against core antigen of the hepatitis b virus (anti-hbc igm) was selectively determined by a new enzyme immunoassay (eia). microtiter plates were coated with anti-human micro chain immunoglobulin. on addition of serum igm is bound by a factor of about 4,000 more than igg. after removing the sample, hbcag is added to the igm-coated surface. binding takes place if the igm contained anti-hbc and was demonstrated by the aid of a conjugate made from anti-hbc igg and horse radish peroxida ... | 1979 | 395275 |
| [enzyme-linked assay for detection of hepatitis b virus surface antigen (author's transl)]. | 1979 | 397879 | |
| nucleotide sequence of the hepatitis b virus genome (subtype ayw) cloned in e. coli. | the complete nucleotide sequence of hepatitis b virus genome (subtype ayw) cloned in escherichia coli has been determined using the maxam and gilbert method and the dideoxynucleotide method. this sequence is 3,182 nucleotides long. location of the nonsense codons shows that the coding capacity of the l chain is larger than the coding capacity of the s chain. eight open regions, able to code for polypeptide chains larger than 100 amino acids, have been located. region 6, which is the largest, cov ... | 1979 | 399327 |
| hepatitis b virus genes and their expression in e. coli. | a composite dna sequence of regions of hepatitis b virus, determined from a series of recombinant plasmids, reveals the genes for the surface antigen and the core antigen of the virus. the sequence of the core antigen shows it to be a dna binding protein. the core antigen gene is expressed in escherichia coli and when injected into rabbits the bacterial product induces antibodies which react with core antigen isolated from human sources. | 1979 | 399329 |
| epidemiological survey of hepatitis b virus infections in various groups of population. | an epidemiological survey of hepatitis b virus (hbv) infection has been carried out from 1974 up to 1978 in four laboratories, with the aim of identifying high-risk groups in the population. radioimmunoassay procedures were used in order to detect the hepatitis b surface antigen (hbsag) and the corresponding antibody (anti-hbs) in serum samples from over 100,000 individuals of various geographical origin (mainly from ligury or from other areas in northern italy). the groups of population under m ... | 1979 | 399732 |
| [vaccination against hepatitis b in man]. | the preparation of a vaccine against hepatitis b is described. the vaccine is prepared from the hb viral coat (hbs ag) purified and formalin inactivated. the hbs ag is isolated and purified from the blood of healthy hbs ag positive donors by means of an immunoadsorbent technique. the inocuity and efficacy were tested on chimpanzees. vaccination was then applied in an attempt to protect patients and ward staff in a high risk haemodialysis unit. the efficacy of the vaccine was assessed by humoral ... | 1977 | 401985 |
| [use of a highly-sensitive method of electrophoresis-precipitation for detecting hepatitis b virus antigen in human serum]. | a modification of the highly-sensitive method of electrophoresis-precipitation in polyacrylamide gel used for detection of the virus hepatitis b antigen (hbsag) and the anti-hbsag is described. the method completely retains the specificity of the gel immunodiffusion test, but is 100--2000 times more sensitive in hbsag detection. the sera of patients with different pathology were checked by this method. in comparison with the methods used before the hbsag determination by the mentioned method pro ... | 1977 | 403983 |
| discordant e antigen, dna polymerase activity, and dane particle responses in two patients representing an index case-contact case pair with hepatitis b virus infection. | discordant results for e antigen, dna polymerase activity, and dane particle frequency were noted in the sera of two patients representing an index case-contact case pair with chronic aggressive hepatitis b. the lack of correlation between presence of e antigen and the infecting viral strain, as well as the strong relationship of e antigen to persistent and significant viremia, emphasize the role of the host's immune response in the expression of this antigen. | 1977 | 407311 |
| [significance of eag in hbsag positive families]. | 1977 | 407315 | |
| anti-hb immunoglobulin and its use in the prevention of hepatitis b. | 1977 | 410078 | |
| [on the infectiousness of hbs-antigen-positive medical personnel (author's transl)]. | electronmicroscopic study of 29 hbs-antigen-positive personnel of a large hospital demonstrated virus material in the blood in all instances. in nine cases dane particles, which are the infectious principle of the hepatitis b virus, were also seen. dane-particle-positive personnel in a hospital could well be a risk to the patients if the carrier status or infectiousness of the person is not known. | 1979 | 421666 |
| the hepatitis controversy. environmental control of hepatitis b: how 'safe' is 'safe enough'? | 1979 | 423822 | |
| spread of hepatitis b virus antigen. | 1979 | 426702 | |
| [antigens and antibodies in acute viral hepatitis caused by the b virus. clinical significance]. | three antigen-antibody systems are so far known to be related to viral hepatitis type b. tests for evidencing hbsag and antihbs are easily performed and important for the diagnosis, prevention and study of hepatitis b. the tests for evidencing hbcag and hbc are still the subject of study and research. the presence of hbsag in a subject shows he is hosting hepatitis b virus. it may also be present without hepatopathy or it may be associated with acute or chronic hepatitis b. at the present time t ... | 1979 | 431867 |
| hepatitis b e antigen, dna polymerase activity, and infection of household contacts with hepatitis b virus. | to determine if the presence of hepatitis b e antigen (hbeag) and elevated dna polymerase activity in the serum of chronic hbeag carriers indicate increased contagiousness in a household setting, the household contacts of 74 carriers were prospectively evaluated for serologic evidence of hepatitis b infection. thirty of the hbsag carriers had hbeag and 44 had anti-hbe. twenty-eight hbeag-positive carriers regularly demonstrated elevated dna polymerase when serially drawn serum samples were analy ... | 1979 | 437428 |
| changes in hepatitis b virus dna polymerase in relation to the outcome of acute hepatitis type b. | serum levels of hepatitis b virus specific dna polymerase and hepatitis b e antigen were studied serially in 34 patients with hepatitis b virus infection--20 who had the acute illness and recovered, seven who died with fulminant disease, three who died as a result of subacute hepatic necrosis, and four who went on to develop chronic active hepatitis. dna polymerase activity was present in 16 (80%) and hbeag in 13 (65%) of the uncomplicated cases at presentation and in all of those patients from ... | 1979 | 437551 |
| seroepidemiology of infection with hepatitis a and b viruses in an isolated pacific population. | to determine the prevalence of infection with hepatitis a virus and hepatitis b virus in an isolated population, samples of serum were collected from 574 healthy subjects living on the remote pacific island of funafuti. each specimen was tested for antibody to hepatitis a virus, hepatitis b surface antigen, and antibody to hepatitis b surface antigen by solid-phase radioimmunoassay. overall, 79.8% of the population showed evidence of previous infection with hepatitis a virus, and 72.5% with hepa ... | 1979 | 438552 |
| transmission of hepatitis b virus infection by asymptomatic chronic hbsag carrier mothers. | the courses of 18 children born to 13 chronic hepatitis b surface antigen (hbsag) carrier mothers were followed prospectively for serological and biochemical evidence of type b hepatitis. three children developed transient hbsag positivity accompanied by the appearance of antibody to the hepatitis b core antigen. two others had no detectable hbsag but developed antibody to hbsag. these serological manifestations of hepatitis b virus infection occurred late--6 to 24 months after birth. none of th ... | 1979 | 440870 |
| [clinical studies of the so-called asymptomatic carriers of surface antigen hbsag of hepatitis b virus]. | 1979 | 442638 | |
| lung involvement in essential mixed cryoglobulinemia. | 1979 | 443251 | |
| [radioimmunoassay for the demonstration of antibody against the nucleus of hepatitis b virus (hbcab, anti-hbc) (author's transl)]. | 1979 | 445550 | |
| non-a, non-b hepatitis among participants in a plasmapheresis stimulation program. | non-a, non-b hepatitis was transmitted to seven of nine participants in a red blood cell-stimulation program following transfusion of blood from one asymptomatic donor. five of the seven patients had clinical as well as biochemical evidence of infection, and three of these five were icteric. incubation periods for the clinical cases ranged from 28 to 50 days, and duration of illness was from two to eight weeks. none of the seven patients showed serologic evidence of acute infection or reinfectio ... | 1979 | 448190 |
| cloning and endonuclease mapping of the hepatitis b viral genome. | 1979 | 450088 | |
| [membrano-proliferative glomerulonephritis during hepatitis b virus infection]. | 1979 | 450503 | |
| [the hepatitis b virus markers, in leprous patients (author's transl)]. | the hepatitis b virus markers were studied on 553 leprous sera and 100 controls sera. hbs ag detected by ria were present on 25,4% of leprous and 12% of controls; the anti-hbs by ria were revealed in 44,1% of patients out 38% of controls. the leprous was not carrying this markers were hbe ag or anti-hbe or anti-hbc positive. by this vertical study it appears that 2,4% of the cases presented recent or acute hepatitis; 23% were chronic carriers; 41,7% had been in times past infected but were cured ... | 1979 | 450680 |
| hepatitis b antigens and antibodies in asymptomatic carriers and in chronic liver diseases. | 88% of asymptomatic hepatitis b surface antigen (hbsag) carriers and 97% of hbsag positive patients with chronic hepatitis or non-alcoholic liver cirrhosis showed high titers of antibody to hepatitis b core antigen (anti-hbc). a high titer of anti-hbc, thus suggested to be an indicator of persistent hepatitis b virus infection, was found rarely in seronegative patients with chronic hepatitis, non-alcoholic cirrhosis, or alcoholic liver diseases. it was not revealed in idiopathic portal hypertens ... | 1979 | 452007 |
| chronic hepatitis associated with drug abuse: significance of hepatitis b virus. | 1979 | 452620 | |
| hepatitis b e-antigen and its correlation with other serological markers in chimpanzees. | three chimpanzees experimentally infected with hepatitis b virus, and another three chimpanzees that were hepatitis surface antigen carriers, were studied for the presence of viral antigens and humoral immune responses. quantitative analyses of hepatitis b surface and e-antigens in sequential serum samples at early acute stages revealed cyclic oscillations of these two antigens following a synchronous pattern. similar analyses of anti-e-antigen and anti-hepatitis b core antigen antibodies from t ... | 1979 | 457278 |
| prevalence of hbsag and anti-hbs among delivering women. | a survey of 2,500 delivering women revealed a 7.6% incidence of past infection with hepatitis b virus (hbv) (hbsag or anti-hbs). only 5.9% of the anti-hbs-positive mothers had a possible history of parenteral exposure to hepatitis b and none of the 55 hbsag carriers had such a history. the findings suggest that hbv is endemic and that it is probably spread in part by nonparenteral means. the high rates of hbsag and anti-hbs point to the possible preventive value of routine screenings for this sy ... | 1979 | 462789 |
| [male homosexuals--a group with heightened hepatitis b risk; recommendations for surveillance and treatment]. | 1979 | 463078 | |
| papular acrodermatitis associated with hepatitis b virus infection. | 1979 | 464619 | |
| chronic persistent hepatitis: hepatitis b virus markers and histological follow-up. | twenty-six untreated patients with chronic persistent hepatitis were followed prospectively for one to 17 years (mean 5.6 years). the patients developed no clinical features of chronic liver disease. raised serum transaminase levels were usually, but not consistently, the only biochemical abnormality; gamma globulin values were normal. serum markers of past or present hepatitis b infection were found initially in 14 patients: another two developed markers during their follow-up. nine patients pr ... | 1979 | 468067 |
| electron microscopy of hepatitis b virus components in chronic active liver disease. | eighteen liver biopsy specimens from patients with hepatitis b surface antigen (hbsag) positive chronic aggressive hepatitis were studied by electron microscopy. all cases were selected on the basis of positive liver cell membrane fluorescence for hbsag on immunohistochemical investigation. striking changes in the morphology of the liver cell membrane were observed in nearly all cases. furthermore, a dual aspect of hepatitis b core antigen (hbcag) is described. hbcag particles may occur as eithe ... | 1979 | 469016 |
| nucleotide sequence of the gene coding for the major protein of hepatitis b virus surface antigen. | dna extracted from hepatitis b virus dane particles has been cloned in bacteria using a plasmid vector. a full-length clone has been examined by restriction endonuclease analysis, and the nucleotide sequence of an 892-base pair fragment from cloned hepatitis b viral dna encoding the surface antigen gene is reported. the amino acid sequence deduced from the dna indicates that the surface antigens is a protein consisting of 226 amino acids and with a molecular weight of 25,398. the portion of the ... | 1979 | 471053 |
| [markers of infectivity and diffusion of hepatitis b virus infection in a dialysis unit]. | 1979 | 471350 | |
| [chronic hepatitis b. relations between hepatitis virus and the immunological response]. | 1979 | 472398 | |
| etiology of hepatitis b surface antigen (hbsag)-negative chronic hepatitis. | a study was undertaken to elucidate the etiology of hbsag-negative chronic hepatitis. form 37 individuals with hbsag-negative chronic hepatitis, 11 had liver membrane autoantibody (lma) and were thus classified as autoimmune. 6 patients had anti-hbc, 1 of which was also positive for lma. the majority of individuals with hbsag-negative chronic hepatitis had antibodies to hepatitis a antigen (anti-hav), in general at low titer. we conclude from our data that hepatitis a and hepatitis b virus infec ... | 1979 | 478201 |
| hbeag and anti-hbe detection by radioimmunoassay: correlation with vertical transmission of hepatitis b virus in taiwan. | a sensitive radioimmunoassay technique was used to detect hepatitis b e antigen (hbeag). a strong correlation was found between hbeag positivity of the serum of hepatitis b surface antigen (hbsag) carrier women in taiwan and the subsequent development of surface antigenemia in their babies. all babies who became chronic hbsag carriers were born to hbeag positive women, maternal hbeag positivity being a better prior indication of chronic antigenemia developing in the baby than the hbsag titer in ... | 1979 | 479860 |
| failure of maternofetal transmission for small as well as large molecular hepatitis b e antigen. | 1979 | 480018 | |
| hbsag immune complexes in the course of infection with hepatitis b virus. | 1979 | 487641 | |
| present status of hepatitis b vaccine. | 1979 | 492191 | |
| hepatitis b virus markers in 97 long-term hemodialysis patients. | a study was undertaken to assess the state of hepatitis b virus (hbv) infection in hemodialysis patients. from 97 hemodialysis patients tested, 51 were found to have at least one hepatitis b virus specific marker. 18 were hbsag carriers, 12 of these carriers have to be regarded as infectious as judged from the presence of hbeag and/or hbv-specific dna polymerase activity in the serum. antinuclear antibodies (ana) were found in the sera of approximately 20% of the hemodialysis patients with a hig ... | 1979 | 492411 |
| prevalence of hbeag, anti-hbe and dane particle-associated dna polymerase activity in asymptomatic carriers of hbsag. | hbeag/anti-hbe and dane particle-associated dna polymerase activity were detected in serum samples from 358 hbsag asymptomatic carriers found during normal routine screening of 11,200 blood donors (hbsag prevalence 3.1%). since virus specific dna polymerase activity and hbeag seem to be associated in some way with hepatitis b virus infectivity and liver damage, 5% of the hbsag carriers examined, as detected by the presence of hbeag, and 9.5%, as shown by dna polymerase activity, can be expected ... | 1979 | 493812 |
| a large-scale survey on the prevalence of hbeag and anti-hbe among asymptomatic carriers of hbv. correlation with sex, age, hbsag titre and s-gpt value. | during september and october of 1977, a total of 342,407 apparently healthy blood donors were screen for hbsag by reversed pha, and 6,342 (1.9%) asymptomatic carriers of hbv were identified. prevalence of hbeag and anti-hbe among hbv carriers was tested by our immunodiffusion method after serum samples had been concentrated threefold. the results were evaluated with reference to sex and age of donors, as well as hbsag titre and s-gpt level in the serum. hbeag was found slightly but significantly ... | 1979 | 494592 |
| [hepatitis b virus infection in patients with hansen's disease. iv. detection of further markers (hbe ag, anti-hbe, anti-hbc) in the blood]. | 1979 | 498941 | |
| sites that bind polymerized albumin on hepatitis b surface antigen particles: detection by radioimmunoassay. | antibodies to polymerized human albumin (poly-hsa) could not be detected by using sensitive methods (enzyme-linked immunosorbent assay and radioimmunoprecipitation) in sera from chronic carriers of hepatitis b surface antigen (hbsag) or in serial bleedings from one chimpanzee infected with type a hepatitis virus and one infected with non-a, non-b hepatitis virus. by a solid-phase radioimmunoassay, receptor sites for poly-hsa could be detected on hbsag particles from sera containing either hepati ... | 1979 | 500199 |
| failure to detect hepatitis b surface antigen (hbsag) in feces of hbsag-positive persons. | since previous studies did not provide conclusive data regarding the presence of hepatitis b surface antigen (hbsag) in the feces of hbsag carriers, the feces of 20 hbsag carriers and six patients with hbsag-positive active liver disease were examined with use of a reproducible method for concentrating and detecting hbsag in feces in which bovine serum, which has been shown to protect hbsag destruction by fecal components, was added to the fecal specimens. hbsag was not detected in 66 fecal spec ... | 1979 | 501151 |
| persistence of hepatitis b surface antigen in the bedbug cimex hemipterus (fabr.). | the fate of hepatitis b virus in the bedbug was investigated to assess this insect's potential as a vector. colony-reared cimex hemipterus (fabr.) were fed once on blood positive for hepatitis b surface antigen (hbsag). the insects were sampled at intervals thereafter and tested for hbsag by radioimmunoassay. hbsag persisted for up to six weeks in the bedbug's body after a single hbsag-positive meal, during which time several further hbsag-negative blood meals were taken. this result explains th ... | 1979 | 501152 |