Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| long-term persistence of immunity after hepatitis b vaccination: is this substantiated by the literature? | hepatitis b vaccination is held to provide life-long protection against hepatitis b virus (hbv) infection, but evidence for this notion remains wanting, since no studies have assessed the vaccinees in their fourth decade of life. indeed, there are several reports indicating that despite vaccination in infancy, the prevalence of hbv infection still increased with age in the vaccinees, and that both anti-hbs titer and anamnestic response declined with age. clearly it is time to clarify the long-te ... | 2017 | 28277087 |
| correlations of microvascular blood flow of contrast-enhanced ultrasound and hgf/c-met signaling pathway with clinicopathological features and prognosis of patients with hepatocellular carcinoma. | the study is designed to explore the correlations of microvascular blood flow of contrast-enhanced ultrasound (ceus) and hepatocyte growth factor (hgf)/c-met signaling pathway with clinicopathological features and prognosis of patients with hepatocellular carcinoma (hcc). one hundred and eighteen patients pathologically diagnosed as primary hcc were selected. all hcc patients underwent ceus examination before operation. hcc tissues and adjacent normal tissue specimens were obtained to detect the ... | 2017 | 28243120 |
| prognostic value of increased expression of raco-1 in patients with hepatitis b-related hepatocellular carcinoma. | ring domain ap-1 coactivator-1 (raco-1) is a coactivator that links c-jun to growth factor signaling and is essential for ap-1 function. this study aimed to investigate the expression and clinical significance of raco-1 protein in hepatitis b virus (hbv)-related hepatocellular carcinoma (hcc) in china. a total of 136 tissue samples of hbv-related hcc were detected by immunohistochemistry (including 76 patients in training cohort and 60 patients in validation cohort). correlation between raco-1 e ... | 2017 | 28243109 |
| the development of hepatocarcinoma after long-term antivirus treatment of chinese patients with chronic hepatitis b virus infection: incidence, long-term outcomes and predictive factors. | patients with chronic hepatitis b virus (hbv) infection are at high risk for progressing to decompensated cirrhosis and hepatocellular carcinoma (hcc). although long-term treatment with nucleos(t)ide analogues (nas) benefits patients with chronic hepatitis b (chb), many develop hcc. therefore, the clinical outcomes of patients chb who undergo long-term treatment with nas remain to be identified. the aim of this study therefore was to evaluate the risk and predictors of patients with chb who deve ... | 2017 | 28237828 |
| the epsilon motif of hepatitis b virus rna exhibits a potassium-dependent ribonucleolytic activity. | fourteen different classes of ribozymes are known that catalyse a range of diverse chemical reactions. we report here a novel potassium-dependent nucleolytic activity present in hepatitis b virus (hbv) rna. a short rna region (53 nt) with enzymatic properties released itself from the viral sequence by cis cleavages and could subsequently act in trans. the released region encompassed the epsilon motif present in the hbv rna. the 3' end of the liberated fragment was within the noncanonical polyade ... | 2017 | 28236666 |
| impaired expression and function of tlr8 in chronic hbv infection and its association with treatment responses during peg-ifn-α-2a antiviral therapy. | toll-like receptor 8 (tlr8) plays an important role in controlling chronic viral infections. however, the role of tlr8 in chronic hepatitis b virus (hbv) infection is poorly understood. in this study, we aimed to investigate the expression and function of tlr8 in peripheral blood mononuclear cells (pbmcs) of chronic hepatitis b (chb) patients and its alteration during peg-ifn-α-2a therapy. | 2017 | 28236535 |
| prmt5 restricts hepatitis b virus replication via epigenetic repression of cccdna transcription and interference with pgrna encapsidation. | chronic hepatitis b virus (hbv) infection remains a major health problem worldwide. the covalently closed circular dna (cccdna) minichromosome, which serves as the template for the transcription of viral rnas, plays a key role in viral persistence. while accumulating evidence suggests that cccdna transcription is regulated by epigenetic machinery, particularly the acetylation of cccdna-bound histone 3 (h3) and h4, the potential contributions of histone methylation and related host factors remain ... | 2017 | 28236308 |
| characterization of hepatitis b virus (hbv) pres/s gene mutations in blood donors with occult hbv infection in the baoji area of north china. | occult hepatitis b virus (hbv) infection (obi) in blood donors was investigated in the baoji area of north china, and obi-related viral mutations in donors were characterized. | 2017 | 28236303 |
| hepatic deficiency of the pioneer transcription factor foxa restricts hepatitis b virus biosynthesis by the developmental regulation of viral dna methylation. | the foxa family of pioneer transcription factors regulates hepatitis b virus (hbv) transcription, and hence viral replication. hepatocyte-specific foxa-deficiency in the hbv transgenic mouse model of chronic infection prevents the transcription of the viral dna genome as a result of the failure of the developmentally controlled conversion of 5-methylcytosine residues to cytosine during postnatal hepatic maturation. these observations suggest that pioneer transcription factors such as foxa, which ... | 2017 | 28235042 |
| lamivudine, entecavir, or tenofovir treatment of hepatitis b infection: effects on calcium, phosphate, fgf23 and indicators of bone metabolism. | patients with chronic hepatitis b virus (hbv) are often treated with nucleoside/nucleotide antiviral agents and metabolic bone toxicity is a possible concern. | 2017 | 28233741 |
| quantitative nucleic acid amplification methods and their implications in clinical virology. | recently, a number of techniques have been approved for quantification of viral nucleic acids in clinical samples. viral load (vl) tests have considerable importance in the management of patients and are widely used in routine diagnosis. in clinical virology, vl testing are important to monitor the antiviral treatment, to initiate preemptive therapy, to understand pathogenesis, and to evaluate the infectivity. these tests have now become a part of many diagnostic and treatment guidelines. consid ... | 2017 | 28251100 |
| hepatitis b and nafld: lives crossed. | hepatitis b virus infection seems to protect against steatosis and insulin resistance decreasing nafld. metabolic syndrome has been associated with increased risk of disease progression to cirrhosis and liver cancer in hepatitis b. hbsag seroclearance increased over time and it could be a confounding factor when analysing nafld and hepatitis b prevalence. | 2017 | 28233740 |
| label-free detection of hepatitis b virus using solution immersed silicon sensors. | highly sensitive solution immersed silicon (sis) biosensors were developed for detection of hepatitis b virus (hbv) infection in the early stage. the ultrasensitivity for overlayer thickness at the nonreflecting condition for the p-polarized wave is the basis of sis sensing technology. the change in thickness due to biomolecular interactions and change in refractive index of the surrounding buffer medium were assessed simultaneously using two separate ellipsometric parameters (ψ and δ), respecti ... | 2017 | 28231713 |
| association of neutrophil-lymphocyte ratio and t lymphocytes with the pathogenesis and progression of hbv-associated primary liver cancer. | the neutrophil-lymphocyte ratio (nlr) is a new prognostic predictor for patients with liver cancer. the association of nlr and t lymphocytes with the pathogenesis and progression of liver cancer is poorly understood. | 2017 | 28231294 |
| potential of cannabidiol for the treatment of viral hepatitis. | viral hepatitis b (hbv) and hepatitis c (hcv) pose a major health problem globally and if untreated, both viruses lead to severe liver damage resulting in liver cirrhosis and cancer. while hbv has a vaccine, hcv has none at the moment. the risk of drug resistance, combined with the high cost of current therapies, makes it a necessity for cost-effective therapeutics to be discovered and developed. the recent surge in interest in medical cannabis has led to interest in evaluating and validating th ... | 2017 | 28250664 |
| serum lipid profile as a marker of liver impairment in hepatitis b cirrhosis patients. | chronic hbv infection is a major cause of cirrhosis and an important risk factor to develop hepatocellular carcinoma. the study is conducted to find out the changes in the lipid metabolism of hbv-cirrhosis patients. | 2017 | 28249586 |
| reactivation of occult hbv infection in an hiv/hcv co-infected patient successfully treated with sofosbuvir/ledipasvir: a case report and review of the literature. | reactivation of occult or inactive hepatitis b virus (hbv) infection during immunosuppressant treatments is well known and widely described in literature. the same observation has been made in hepatitis c (hcv)-infected patients previously exposed to hbv and treated with interferon-free daa treatments. because of common transmission routes, persons may have been exposed to hcv, hbv and hiv, but few cases have been reported in this scenario to date. frequency of hbv reactivation in hiv/hcv co-inf ... | 2017 | 28249574 |
| evaluation of two vidas (®)prototypes for detecting anti-hev igg. | high performance anti-hepatitis e virus (hev) igg assays are crucial for epidemiology. | 2017 | 28249234 |
| the independent predictors of significant liver histological changes in chronic hepatitis b virus infection patients with persistently high-normal or low-normal alanine transaminase levels. | to determine the independent predictors of significant liver histological changes (slhc) defined as inflammatory grade ≥a2 and/or fibrosis stage ≥f2 using the metavir scoring system in chronic hepatitis b virus (hbv) infection patients with persistently normal alt (pnalt) levels. | 2017 | 28245424 |
| reactivation of hepatitis b in patients of chronic hepatitis c with hepatitis b virus infection treated with direct acting antivirals. | hepatitis b virus (hbv) may reactivate when treating chronic hepatitis c (chc) with direct acting antivirals (daa). we aim to investigate the risk of hbv reactivation during daa therapy. | 2017 | 28230928 |
| prec and c regions of woodchuck hepatitis virus facilitate persistent expression of surface antigen of chimeric whv-hbv virus in the hydrodynamic injection balb/c mouse model. | in the hydrodynamic injection (hi) balb/c mouse model with the overlength viral genome, we have found that woodchuck hepatitis virus (whv) could persist for a prolonged period of time (up to 45 weeks), while hepatitis b virus (hbv) was mostly cleared at week four. in this study, we constructed a series of chimeric genomes based on hbv and whv, in which the individual sequences of a 1.3-fold overlength hbv genome in pbs-hbv1.3 were replaced by their counterparts from whv. after hi with the whv-hb ... | 2017 | 28230775 |
| seroprevalence of hepatitis b, hepatitis c, human immunodeficiency virus, treponema pallidum, and co-infections among blood donors in kyrgyzstan: a retrospective analysis (2013-2015). | post-soviet kyrgyzstan has experienced a major surge in blood-borne infections, but data from adequately powered, up-to-date studies are lacking. we thus examined a) the seroprevalences of hepatitis b virus surface antigen (hbsag), hiv-1 p24 antigen and antibodies against hepatitis c virus (anti-hcv), human immunodeficiency viruses (anti-hiv-1/2, hiv-1 group o), and treponema pallidum among blood donors in kyrgyzstan and assess their distribution according to sex, age, and provinces of residence ... | 2017 | 28222792 |
| are non-invasive fibrosis markers for chronic hepatitis b reliable in sub-saharan africa? | in the absence of liver biopsy, the world health organization recommends non-invasive tests, such as aspartate aminotransferase to platelet ratio index and fib-4, to assess liver fibrosis in patients with chronic hepatitis b. however, these tests are not well validated in sub-saharan africa. recently, a new marker, gamma-glutamyl transpeptidase to platelet ratio, was found to be more accurate in an african setting, but this needs confirmation in other cohorts. | 2017 | 28222249 |
| multicenter study of skin rashes and hepatotoxicity in antiretroviral-naïve hiv-positive patients receiving non-nucleoside reverse-transcriptase inhibitor plus nucleoside reverse-transcriptase inhibitors in taiwan. | two nucleos(t)ide reverse-transcriptase inhibitors (nrtis) plus 1 non-nrti (nnrti) remain the preferred or alternative combination antiretroviral therapy (cart) for antiretroviral-naive hiv-positive patients in taiwan. the three most commonly used nnrtis are nevirapine (nvp), efavirenz (efv) and rilpivirine (rpv). this study aimed to determine the incidences of hepatotoxicity and skin rashes within 4 weeks of initiation of cart containing 1 nnrti plus 2 nrtis. | 2017 | 28222098 |
| quantitative (13)c traces of glucose fate in hepatitis b virus-infected hepatocytes. | quantitative characterization of (13)c-labeled metabolites is an important part of the stable isotope tracing method widely used in metabolic flux analysis. given the long relaxation time and low sensitivity of (13)c nuclei, direct measurement of (13)c-labeled metabolites using one-dimensional (13)c nmr often fails to meet the demand of metabolomics studies, especially with large numbers of samples and metabolites having low abundance. although hsqc-based 2d nmr methods have improved sensitivity ... | 2017 | 28221022 |
| status of hbsag seroprevalence in 15 million rural couples in china: a cross-sectional study. | a cross-sectional analysis of prevalence of hepatitis b virus infection (hbv) among rural couples was conducted between 2010 and 2014. serologic hbv markers, including hepatitis b surface antigen (hbsag) and e antigen (hbeag), were tested. primary outcome of interest comprised hbsag positivity in couples (both positive: f+m+, only wife positive: f+m-, only husband positive: f-m+), and secondary outcome consisted of prevalence and risk factors of hbsag positivity among husbands or wives. of 14,81 ... | 2017 | 28220812 |
| [diagnosis and treatment of chronic hepatitis b and d. national consensus guideline in hungary from 15 october 2016]. | diagnosis and treatment of hbv/hdv infection means for the patient to be able to maintain working capacity, to increase quality of life, to prevent cancer, and to prolong life expectancy, while society benefits from eliminating the chances of further transmission of the viruses, and decreasing the overall costs of serious complications. the guideline delineates the treatment algorithms for 2017 set by a consensus meeting of physicians involved in the treatment of these diseases. the prevalence o ... | 2017 | 28218868 |
| a noninvasive diagnostic model to assess nonalcoholic hepatic steatosis in patients with chronic hepatitis b. | the objective of this study was to develop a noninvasive diagnostic test for nonalcoholic hepatic steatosis in patients with chronic hepatitis b (chb) by using routinely available clinical markers. | 2017 | 28203279 |
| the new aptima hbv quant real-time tma assay accurately quantifies hepatitis b virus dna from genotypes a to f. | sensitive and accurate hepatitis b virus (hbv) dna detection and quantification are essential to diagnose hbv infection, establish the prognosis of hbv-related liver disease, and guide the decision to treat and monitor the virological response to antiviral treatment and the emergence of resistance. currently available hbv dna platforms and assays are generally designed for batching multiple specimens within an individual run and require at least one full day of work to complete the analyses. the ... | 2017 | 28202793 |
| hiv and sti s among men who have sex with men in dodoma municipality, tanzania: a cross-sectional study. | to determine the seroprevalence of hiv, sti and related risks among men who have sex with men (msm) in dodoma municipality, tanzania. | 2017 | 28202736 |
| high prevalence of hepatitis b virus infection in the age range of 20-39 years old individuals in lome. | hepatitis b is a liver infection caused by the hepatitis b virus (hbv). it affects all women and men irrespective of age. although sub-saharan africa is an area of high prevalence of this disease, data on the prevalence of acute and chronic hbv infections in this region remain to be widely documented. | 2017 | 28217218 |
| hepatitis b virus x protein stimulates high mobility group box 1 secretion and enhances hepatocellular carcinoma metastasis. | hepatitis b virus x protein (hbx) plays an important role in the progression of hepatocellular carcinoma. here we reported that overexpression of hbx in hepatocellular carcinoma (hcc) cells could induce the secretion of high-mobility group box 1 (hmgb1) to promote invasion and metastasis of hcc in an autocrine/paracrine manner. hbx triggered an increase of cytoplasmic calcium and activated camkk/camkiv pathway, leading to subsequent translocation and release of hmgb1. hmgb1 neutralizing antibody ... | 2017 | 28216372 |
| factors associated with persistent increase in level of alanine aminotransferase in patients with chronic hepatitis b receiving oral antiviral therapy. | despite complete suppression of viral dna with antiviral agents, in some patients with chronic hepatitis b (chb), serum levels of alanine aminotransferase (alt) do not normalize. we investigated factors associated with persistent increases in level of alt in patients with chb given long-term tenofovir disoproxil fumarate. | 2017 | 28215615 |
| atorvastatin decreases hbx-induced phospho-akt in hepatocytes via p2x receptors. | hepatocellular carcinoma (hcc) is rated as the fifth most common malignancy and third in cancer related deaths worldwide. statins, hmg-coa reductase inhibitors, are potent cholesterol lowering drugs and recent epidemiological evidence suggests that statins prevent aggressive hcc development. previous experiments revealed that statins downregulate phosphorylated akt (pakt). here, it is demonstrated that atorvastatin decreases nuclear pakt levels in pancreatic and lung cancer cell lines within min ... | 2017 | 28209758 |
| adenovirus vector harboring the hbcag and tripeptidyl peptidase ii genes induces potent cellular immune responses in vivo. | chronic hepatitis b virus (hbv) infection is associated with a weak but specific cellular immune response of the host to hbv. tripeptidyl peptidaseⅱ (tppⅱ), an intracellular macromolecule and proteolytic enzyme, plays an important complementary and compensatory role for the proteasome during viral protein degradation and major histocompatibility complex class i antigen presentation by inducing a specific cellular immune response in vivo. based on a previous study, we aimed to explore the role of ... | 2017 | 28214886 |
| hepatitis b virus core antigen stimulates il-6 expression via p38, erk and nf-κb pathways in hepatocytes. | hepatitis b virus (hbv) causes both acute and chronic liver injury. viral proteins are involved in the pathological progress. hepatitis b core antigen (hbcag), a component of viral nucleocapsid, is not only essential for hbv lifecycle, but also exhibits strong immunogenicity. the cytoplasmic location of hbcag in liver biopsy is associated with liver injury and inflammation, but the exact mechanisms remain to be elaborated. | 2017 | 28214858 |
| hepatitis b virus x protein reduces podocyte adhesion via downregulation of α3β1 integrin. | hepatitis b virus (hbv)-associated glomerulonephritis (hbv-gn) is characterized by a reduced number of podocytes due to apoptosis and shedding from the basement membrane. however, the pathological mechanism of hbv-gn is unclear. we previously showed that hepatitis b virus x protein (hbx) promotes apoptosis in tubular epithelial cells. in this study, we transfected podocytes with hbx and examined the effects on adhesion and apoptosis of these cells. | 2017 | 28214836 |
| woodchuck sodium taurocholate cotransporting polypeptide supports low-level hepatitis b and d virus entry. | sodium taurocholate cotransporting polypeptide (ntcp) is the functional receptor for human hepatitis b virus (hbv) and its satellite hepatitis d virus (hdv). species barriers to hbv/hdv infection are mainly determined at entry level by variations in the sequences of particular ntcp orthologs. in this study, we sought to determine whether the ntcp ortholog in woodchuck (marmota monax), woodchuck ntcp (wntcp) supports viral infection. we found that wntcp is capable of supporting hbv/hdv infection ... | 2017 | 28213271 |
| genome-wide identification of direct hbx genomic targets. | the hepatitis b virus (hbv) hbx regulatory protein is required for hbv replication and involved in hbv-related carcinogenesis. hbx interacts with chromatin modifying enzymes and transcription factors to modulate histone post-translational modifications and to regulate viral cccdna transcription and cellular gene expression. aiming to identify genes and non-coding rnas (ncrnas) directly targeted by hbx, we performed a chromatin immunoprecipitation sequencing (chip-seq) to analyse hbv recruitment ... | 2017 | 28212627 |
| possible impact of 190g > a ccr2 and δ32 ccr5 mutations on decrease of the hbv vaccine immunogenicity-a preliminary report. | background: chemokine genetic variations are involved in infectious diseases such as hepatitis b virus (hbv). several allelic variants might, in theory, affect the outcome of vaccination. objectives: this study was carried out to examine the associations of δ32 ccr5 and 190g > a ccr2 polymorphisms with a response to a primary course of three hbv vaccinations. methods: between december 2014 and december 2016, patients from three randomly selected primary care clinics in the west pomeranian region ... | 2017 | 28208753 |
| virological and serological features of acute hepatitis b in adults. | various viral kinetics among patients with acute hepatitis b (ahb) have been observed in clinical practice. this study investigated the virological, biochemical, and serological characteristics of ahb in adults.a total of 192 adult patients with ahb were recruited between december 2010 and january 2014. the quantification of biochemical and serologic markers for hepatitis b virus (hbv) infection was monitored from the onset.of the 192 patients, 113 patients were followed up. one patient died due ... | 2017 | 28207518 |
| is serum angiotensin-converting enzyme level useful for determining necroinflammatory activity in chronic hepatitis b infection? | the purpose of this study was to investigate the relationship between the findings from liver biopsy and the serum angiotensin-converting enzyme (ace) level to determine whether ace might serve as a potential noninvasive sign of necroinflammatory activity in patients with chronic hepatitis b (chb) infection. | 2017 | 28207324 |
| hepatitis b reactivation in patients with chronic hepatitis c undergoing anti-viral therapy with an interferon-free regimen. | a few cases of hepatitis b virus (hbv) reactivation during anti-viral therapy against hepatitis c (hcv) have been reported. however, the information regarding the real impact of this phenomenon is scarce. | 2017 | 28206681 |
| heteroaryldihydropyrimidine (hap) and sulfamoylbenzamide (sba) inhibit hepatitis b virus replication by different molecular mechanisms. | heteroaryldihydropyrimidine (hap) and sulfamoylbenzamide (sba) are promising non-nucleos(t)ide hbv replication inhibitors. haps are known to promote core protein mis-assembly, but the molecular mechanism of abnormal assembly is still elusive. likewise, the assembly status of core protein induced by sba remains unknown. here we show that sba, unlike hap, does not promote core protein mis-assembly. interestingly, two reference compounds hap_r01 and sba_r01 bind to the same pocket at the dimer-dime ... | 2017 | 28205569 |
| hepatitis b reactivation associated with immune suppressive and biological modifier therapies: current concepts, management strategies, and future directions. | hepatitis b reactivation associated with immune-suppressive and biological therapies is emerging to be an important cause of morbidity and mortality in patients with current or prior exposure to hepatitis b virus (hbv) infection. the population at risk for hbv reactivation includes those who either currently are infected with hbv or have had past exposure to hbv. because curative and eradicative therapy for hbv is not currently available, there is a large reservoir of individuals at risk for hbv ... | 2017 | 28219691 |
| outcomes of kidney transplantation in patients exposed to hepatitis b virus: analysis by phase of infection. | in kidney transplant recipients (ktrs) with hepatitis b virus (hbv) infection, immunosuppression may increase viral replication with increased risk for liver disease progression and hbv-related kidney diseases, factors that could adversely influence graft and patient outcomes. we aimed to analyze the impact of different phases of hbv infection on the outcomes in ktrs. | 2017 | 28219584 |
| differential expression of innate immune response genes in clinical phases of chronic hepatitis b infection. | we investigated innate immune gene expression in clinical phases of chronic hepatitis b infection, including immune tolerant (it), immune active (ia), inactive carrier (ic) and hepatitis b e antigen (hbeag)-negative phases, as well as healthy controls. expression levels of interferon types i, ii and iii, their receptor subunits, irfs, tlrs and other ifn-induced genes in peripheral blood mononuclear cells were compared. forty hbsag-positive treatment-naïve subjects without co-infection with hiv, ... | 2017 | 28218976 |
| a retrospective study of hepatitis b mother-to-child transmission prevention and postvaccination serological test results of infants at risk of perinatal transmission in two counties of middle china. | approximately, 240 million people have chronic hepatitis b worldwide, with mother-to-child-transmission (mtct) accounting for most cases. therefore, henan province, china launched a public health programme to prevent mtct. to determine the efficacy of this health programme, a survey was carried out in huixian and xinan counties, which are located in northern and western henan. all infants born in these two counties between january 1, 2013 and march 31, 2014 to a mother positive for hepatitis b s ... | 2017 | 28199772 |
| performance of hbsag quantification assays for detection of hepatitis b virus genotypes and diagnostic escape-variants in clinical samples. | the impact of hepatitis b virus (hbv) genomic variability on the measurement of hbsag level has been poorly evaluated. | 2017 | 28189936 |
| comparison of the efficacy and safety of entecavir and tenofovir in nucleos(t)ide analogue-naive chronic hepatitis b patients with high viraemia: a retrospective cohort study. | the aims of this study are to compare the long-term efficacy and safety of entecavir and tenofovir in nucleos(t)ide analogue (na)-naive patients with chronic hepatitis b (chb) with high hepatitis b virus (hbv) dna (> 6 log10 iu/ml). | 2017 | 28189857 |
| the role of st2 and st2 genetic variants in schistosomiasis. | chronic schistosomiasis and its severe complication, periportal fibrosis, are characterized by a predominant th2 response. to date, specific single nucleotide polymorphisms in st2 have been some of the most consistently associated genetic variants for asthma. | 2017 | 28189770 |
| hepatitis b immunoglobulin during pregnancy for prevention of mother-to-child transmission of hepatitis b virus. | hepatitis is a viral infection of the liver. it is mainly transmitted between people through contact with infected blood, frequently from mother to baby in-utero. hepatitis b poses significant risk to the fetus and up to 85% of infants infected by their mothers at birth develop chronic hepatitis b virus (hbv) infection. hepatitis b immunoglobulin (hbig) is a purified solution of human immunoglobulin that could be administered to the mother, newborn, or both. hbig offers protection against hbv in ... | 2017 | 28188612 |
| kinetics of hepatitis b surface antigen level in chronic hepatitis b patients who achieved hepatitis b surface antigen loss during pegylated interferon alpha-2a treatment. | hepatitis b surface antigen (hbsag) loss/seroconversion is considered to be the ideal endpoint of antiviral therapy and the ultimate treatment goal in chronic hepatitis b (chb). this study aimed to assess the patterns of hbsag kinetics in chb patients who achieved hbsag loss during the treatment of pegylated interferon (peg-ifn) α-2a. | 2017 | 28229987 |
| comparison of the qiagen artus hbv qs-rgq assay with the roche cobas ampliprep/cobas taqman hbv assay for quantifying viral dna in sera of chronic hepatitis b patients. | hepatitis b virus dna quantification is essential for managing chronic hepatitis b (chb). we compared the performance of artus hbv qs-rgq (qiagen gmbh, germany) and cap/ctm v2.0 hbv assays (roche molecular diagnostics, usa) in chb patients. | 2017 | 28224771 |
| baseline hbv load increases the risk of anti-tuberculous drug-induced hepatitis flares in patients with tuberculosis. | hepatitis associated anti-tuberculous treatment (hatt) has been a main obstacle in managing patients co-infected with mycobacterium tuberculosis and hepatitis b virus (hbv). therefore, we evaluated the factors related to the severity of adverse effects during hatt, especially those associated with liver failure. a retrospective study was carried out at tongji hospital from 2007 to 2012. increases in serum transaminase levels of >3, 5, and 10 times the upper limit of normal (uln) were used to def ... | 2017 | 28224437 |
| effects of sex and generation on hepatitis b viral load in families with hepatocellular carcinoma. | to explore factors associated with persistent hepatitis b virus (hbv) infection in a cohort of hepatocellular carcinoma (hcc)-affected families and then investigate factors that correlate with individual viral load among hepatitis b surface antigen (hbsag)-positive relatives. | 2017 | 28223732 |
| prodromal fever indicates a high risk of liver failure in acute hepatitis b. | the role of prodromal fever in the clinical course of acute hepatitis b virus (hbv) infection is still largely unclear. this study was conducted to investigate the factors associated with prodromal fever and its role in the development of acute liver failure (alf) in patients with acute hepatitis b (ahb). | 2017 | 28223176 |
| a screening assay for the identification of host cell requirements and antiviral targets for hepatitis d virus infection. | hepatitis delta virus (hdv) is a minimalistic satellite virus of hepatitis b virus (hbv). hbv/hdv co-infection, i.e. "hepatitis d", is the most severe form of viral hepatitis. no effective therapy for hdv infection is available partly due to the fact that hdv is a highly host-dependent virus devoid of any potentially drugable enzyme encoded in its small genome. in this study we present a semi-automated method to evaluate hdv infection and replication under the influence of different drugs. we ut ... | 2017 | 28223128 |
| prevalence of hbsag/hbeag amongst 1 936 801 couples preparing for pregnancy in rural china: an observational study. | there are few extant studies on the prevalence of hbv infection in couples preparing for pregnancy. we assessed the prevalence of hepatitis b surface antigen (hbsag) and hepatitis b e antigen (hbeag) in couples preparing for pregnancy in rural china, and the association between hbv prevalence and the statuses of hbsag/hbeag and alt in the spouses. we performed a nationwide cross-sectional study, using data from a health check-up program for 1 936 801 rural couples from 31 provinces preparing for ... | 2017 | 28199770 |
| mutation in the s gene of hepatitis b virus and anti-hbs subtype-nonspecificity contributed to the co-existence of hbsag and anti-hbs in patients with chronic hepatitis b virus infection. | the mechanism for the co-existence of hepatitis b surface antigen (hbsag) and antibodies to hbsag (anti-hbs) in chronic hbv infected patients remains controversial. this study aimed to explore the role of hbv s gene mutation and anti-hbs subtype-nonspecificity in patients with simultaneous hbsag/anti-hbs positivity. chronic hbv infections with (n = 145, group i) and without (n = 141, group ii) anti-hbs were included. the s gene was amplified and sequenced. the neutralization experiment was used ... | 2017 | 28198078 |
| the prevalence and clinicopathological features of breast cancer patients with hepatitis b virus infection in china. | we performed a case-control study to investigate the prevalence and clinicopathological features of breast cancer patients with hepatitis b virus (hbv) infection in china. the clinical data for 2,796 female patients with newly diagnosed, primary breast cancer were evaluated. a total of 234 breast cancer patients with hbv infection (the case group; positive for hepatitis b surface antigen [hbsag]) and 444 breast cancer patients without hbv infection (the control group; negative for hbsag, hepatit ... | 2017 | 28212549 |
| endemic prevalence of hepatitis b and c in mongolia: a nationwide survey among mongolian adults. | in this study a representative group of mongolian adults was tested for hepatitis b virus (hbv) and hepatitis c virus (hcv). screening was conducted at 17 different locations on a randomly sampled group, representative of the mongolian adult population. a total of 1158 adults, 500 (43.1%) men and 659 (56.9%) women were included. the prevalence estimates of hbv and hcv among the general mongolian adult population were found to be 11.1%± 1% (se) and 8.5% ± 0.7% or 207,418 and 160,228 cases, respec ... | 2017 | 28211256 |
| kir2dl3 and the kir ligand groups hla-a-bw4 and hla-c2 predict the outcome of hepatitis b virus infection. | killer immunoglobulin-like receptors (kirs) regulate the activation of natural killer cells through their interaction with human leukocyte antigens (hla). kir and hla loci are highly polymorphic and certain hla-kir combinations have been found to protect against viral infections. in this study we analyzed whether the kir/hla repertoire may influence the course of hepatitis b virus (hbv) infection. fifty-seven subjects with chronic hepatitis b (chb), 44 subjects with resolved hbv infection, and 6 ... | 2017 | 28211154 |
| complete genome sequence of the who international standard for hepatitis b virus dna. | the world health organization (who) international standard (is) for hepatitis b virus (hbv) dna for use in nucleic acid amplification assays was characterized by determining the complete genome sequence, which was assigned genotype a. this information will aid the design, development, and evaluation of hbv dna amplification assays. | 2017 | 28209818 |
| serum lipid alterations identified in chronic hepatitis b, hepatitis b virus-associated cirrhosis and carcinoma patients. | the incidences of chronic hepatitis b (chb), hepatitis b virus (hbv)-associated cirrhosis and hbv-associated carcinoma are high and increasing. this study was designed to evaluate serum lipid metabolite changes that are associated with the progression from chb to hbv-associated cirrhosis and ultimately to hbv-associated hcc. a targeted metabolomic assay was performed in fasting sera from 136 chb patients, 104 hbv-associated cirrhosis, and 95 hbv-associated hcc using ultra-performance liquid chro ... | 2017 | 28198443 |
| predicting short-term survival after liver transplantation on eight score systems: a national report from china liver transplant registry. | to compare the performance of eight score systems (meld, umeld, meld-na. imeld, ukeld, meld-as, ctp, and mctp) in predicting the post-transplant mortality, we analyzed the data of 6,014 adult cirrhotic patients who underwent liver transplantation between january 2003 and december 2010 from the china liver transplant registry database. in hepatitis b virus (hbv) group, meld, umeld and meld-as showed good predictive accuracies at 3-month mortality after liver transplantation; by comparison with ot ... | 2017 | 28198820 |
| a molecular epidemiology study investigating familial clustering of hepatitis b virus infection in families with unfavorable prognoses in northwest china. | hepatitis b virus (hbv) infections and adverse outcome have been demonstrated to show characteristics of familial clustering. the aim of this study was to investigate the prevalence of different hbv genotypes, hbv sub-genotypes, and pre-s mutations associated with familial hbv infection clusters with unfavorable prognoses. families presenting with clustered hbv infections and unfavorable prognoses were enrolled in this study. non-clustered hbv-infected individuals were used as the control group. ... | 2017 | 28198546 |
| development and validation of a prognostic model for acute-on-chronic hepatitis b liver failure. | the canonic study proposed the chronic liver failure consortium acute-on-chronic liver failure (clif-c aclf) prognostic model at the european association for the study of the liver-clif diagnosis. this study aimed to develop and validate a prognostic model for predicting the short-term mortality of hepatitis b virus (hbv) aclf as defined by the asia-pacific association for the study of the liver. | 2017 | 28195876 |
| health-related quality of life in pediatric patients with chronic hepatitis b living in the united states and canada. | to determine if selected socio-demographic and hbv-specific clinical factors are associated with health-related quality of life (hrqol) among pediatric patients chronically infected with hepatitis b virus (hbv). | 2017 | 28169971 |
| th17/treg imbalance is an indicator of liver cirrhosis process and a risk factor for hcc occurrence in hbv patients. | to determine the impact of t helper 17 cell (th17)/regulatory t cell (treg) ratio imbalance on the process and prognosis of hepatitis b virus (hbv)-related liver cirrhosis. | 2017 | 28169127 |
| community seroprevalence of hepatitis b, c and human immunodeficiency virus in adult population in gojjam zones, northwest ethiopia. | in ethiopia, there is lack of data on the prevalence of hepatitis b virus (hbv), hepatitis c virus (hcv) and human immune deficiency virus (hiv) infections in adult population at community level. this study aimed at determining the hbv, hcv and hiv seroprevalence in adult population at community level in east and west gojjam zones in amhara region, ethiopia. | 2017 | 28166829 |
| different courses of hepatitis b reinfection after renal transplant: a case report. | hepatitis b surface antigen-positive allografts may be a source of transmission in patients who undergo renal transplantation. treatment of hepatitis b virus infection with nucleoside/nucleotide analogs in kidney recipients who have hepatitis b virus infection or who have received transplants from hepatitis b surface antigen-positive donors improves long-term patient survival. antiviral agents are administered as a preemptive or prophylactic therapy at the time of kidney transplantation, rather ... | 2017 | 28176616 |
| autologous neohep derived from chronic hepatitis b virus patients' blood monocytes by upregulation of c-met signaling. | in view of the escalating need for autologous cell-based therapy for treatment of liver diseases, a novel candidate has been explored in the present study. the monocytes isolated from hepatitis b surface antigen (hbsag) nucleic acid test (nat)-positive (hnp) blood were differentiated to hepatocyte-like cells (neohep) in vitro by a two-step culture procedure. the excess neutrophils present in hnp blood were removed before setting up the culture. in the first step of culture, apoptotic cells were ... | 2017 | 28170202 |
| economic analysis and budget impact of tenofovir and entecavir in the first-line treatment of hepatitis b virus in italy. | chronic hepatitis b is a common, progressive disease, particularly when viral replication is detected. oral antivirals can suppress viral replication and prevent or delay the development of cirrhosis and liver-related complications. the treatments of chronic hepatitis b cannot totally cure the disease but can prevent its progression to hepatocellular carcinoma, decreasing the levels of both morbidity and mortality. to date, there are several therapies indicated by the international guidelines as ... | 2017 | 28197805 |
| effects of vaccine-acquired polyclonal anti-hbs antibodies on the prevention of hbv infection of non-vaccine genotypes. | in universal hepatitis b (hb) vaccination, single vaccine-derived polyclonal anti-hbs antibodies (anti-hbs) need to inhibit infection of hb viruses (hbv) of non-vaccine genotypes. we experimentally addressed this issue. | 2017 | 28197802 |
| high nkg2a expression contributes to nk cell exhaustion and predicts a poor prognosis of patients with liver cancer. | background and aims: as the predominant lymphocyte subset in the liver, natural killer (nk) cells have been shown to be highly associated with the outcomes of patients with chronic hepatitis b virus infection (chb) and hepatocellular carcinoma (hcc). previously, we reported that nkg2a, a checkpoint candidate, mediates human and murine nk cell dysfunction in chb. however, nk cell exhaustion and, particularly, the level of nkg2a expression within liver tumors have not been reported. methods: in th ... | 2017 | 28197391 |
| knowledge, current status, and barriers toward healthcare worker vaccination among family medicine resident participants in a web-based survey in korea. | we investigated the knowledge, status, and barriers toward healthcare workers receiving vaccinations among korean family medicine residents. to date, a systematic study has not been conducted among medical practitioners examining these variables. | 2017 | 28197329 |
| elevated pre-treatment il-18 level is associated with hbeag seroconversion in hiv-hbv coinfection. | in hepatitis b virus (hbv) infected patients, hepatitis b e antigen (hbeag) seroconversion is associated with better outcomes. interleukin-18 (il-18) controls hepatitis b replication in a mouse model. however, its role in treatment response in hiv/hbv co-infected patients is unknown. | 2017 | 28195558 |
| sodium taurocholate cotransporting polypeptide is the limiting host factor of hepatitis b virus infection in macaque and pig hepatocytes. | infections with the human hepatitis b (hbv) and hepatitis d virus (hdv) depend on species-specific host factors like the receptor human sodium taurocholate cotransporting polypeptide hntcp. complementation of mouse hepatocytes with hntcp confers susceptibility to hdv but not hbv indicating the requirement of additional hbv-specific factors. as an essential premise towards the establishment for an hbv-susceptible animal model, we investigated the role of hntcp as a limiting factor of hepatocytes ... | 2017 | 28195359 |
| pre-s2 mutant-induced mammalian target of rapamycin signal pathways as potential therapeutic targets for hepatitis b virus-associated hepatocellular carcinoma. | chronic hepatitis b virus (hbv) infection is a major risk factor for hepatocellular carcinoma (hcc). pre-s2 mutant represents an hbv oncoprotein that is accumulated in the endoplasmic reticulum (er) and manifests as type ii ground glass hepatocytes (gghs). pre-s2 mutant can induce er stress and initiate multiple er stress-dependent or -independent cellular signal pathways, leading to growth advantage of type ii ggh. importantly, the mammalian target of rapamycin (mtor) signal pathways are consis ... | 2017 | 28195035 |
| targeting mitochondrial dysfunction can restore antiviral activity of exhausted hbv-specific cd8 t cells in chronic hepatitis b. | hepatitis b virus (hbv)-specific cd8 t cells are functionally exhausted in chronic hepatitis b infection, and this condition can be corrected only partially through the modulation of inhibitory pathways, which suggests that a more complex molecular interplay underlies t cell exhaustion. to gain broader insight into this process and identify additional targets for the restoration of t cell function, we compared the transcriptome profiles of hbv-specific cd8 t cells from patients with acute and ch ... | 2017 | 28165481 |
| type i ifn augments il-27-dependent trim25 expression to inhibit hbv replication. | hepatitis b virus (hbv) can cause chronic hepatitis b, which may lead to cirrhosis and liver cancer. type i interferon (ifn) is an approved drug for the treatment of chronic hepatitis b. however, the fundamental mechanisms of antiviral action by type i ifn and the downstream signaling pathway are unclear. trim25 is an ifn-stimulated gene (isg) that has an important role in rig-i ubiquitination and activation. whether trim25 is induced in liver cells by type i ifn to mediate anti-hbv function rem ... | 2017 | 28194021 |
| anti-hbv drugs suppress the growth of hbv-related hepatoma cells via down-regulation of hepatitis b virus x protein. | chronic infection of hepatitis b virus (hbv) is closely associated with the development of hepatocellular carcinoma (hcc). meta-analyses show that adjuvant anti-hbv therapy is effective for hbv-related hcc patients in clinical. however, the significance that anti-hbv drugs depress hcc is poorly understood. here, we investigated the effects of telbivudine (ldt), entecavir (etv) and interferon-α2b (ifn-α2b) on hbv-related hcc. our data showed that the treatment with the drugs significantly suppres ... | 2017 | 28192212 |
| detection of antibodies against hepatitis b virus surface antigen and hepatitis c virus core antigen in plasma with a waveguide-mode sensor. | in large-scale disasters, such as huge significant earthquakes, on-site examination for blood typing and infectious disease screening will be very helpful to save lives of victims who need surgical treatment and/or blood transfusion. however, physical damage, such as building collapse, electric power failure and traffic blockage, disrupts the capacity of the medical system. portable diagnostic devices are useful in such cases of emergency. in this study, we evaluated a waveguide-mode sensor for ... | 2017 | 28190739 |
| hepatitis b virus modulates store-operated calcium entry to enhance viral replication in primary hepatocytes. | many viruses modulate calcium (ca2+) signaling to create a cellular environment that is more permissive to viral replication, but for most viruses that regulate ca2+ signaling, the mechanism underlying this regulation is not well understood. the hepatitis b virus (hbv) hbx protein modulates cytosolic ca2+ levels to stimulate hbv replication in some liver cell lines. a chronic hbv infection is associated with life-threatening liver diseases, including hepatocellular carcinoma (hcc), and hbx modul ... | 2017 | 28151934 |
| sonography predicts liver steatosis in patients with chronic hepatitis b. | liver inflammation and fibrosis may impair the ability of sonography to identify steatosis. we determined the accuracy of sonography in grading steatosis in patients with chronic hepatitis b compared to liver biopsy. | 2017 | 28151547 |
| role of tlr9 in oncogenic virus-produced cancer. | nucleic acid recognition by toll-like receptor 9 (tlr9) initiates signaling pathways that regulate the production of proinflammatory cytokines or type i interferons, as well as many other molecules required to initialize the immune response. the use of synthetic oligodeoxynucleotides (odns) has been crucial to emulate the recognition of dna sequences by tlr9. furthermore, odn administration to mice has shown to confer protection against a wide range of viral, bacterial, and parasitic pathogens. ... | 2017 | 28151089 |
| tenofovir has inferior efficacy in adefovir-experienced chronic hepatitis b patients compared to nucleos(t)ide-naïve patients. | a recent study reported that entecavir had inferior efficacy in nucleos(t)ide analogue (na)-experienced chronic hepatitis b (chb) patients compared to na-naïve patients. we sought to compare the efficacy of tenofovir disoproxil fumarate (tdf) in na-experienced and na-naïve chb patients. | 2017 | 28190329 |
| development of a hepatitis b virus reporter system to monitor the early stages of the replication cycle. | currently, it is possible to construct recombinant forms of various viruses, such as human immunodeficiency virus 1 (hiv-1) and hepatitis c virus (hcv), that carry foreign genes such as a reporter or marker protein in their genomes. these recombinant viruses usually faithfully mimic the life cycle of the original virus in infected cells and exhibit the same host range dependence. the development of a recombinant virus enables the efficient screening of inhibitors and the identification of specif ... | 2017 | 28190076 |
| c-terminal truncated hepatitis b virus x protein regulates tumorigenicity, self-renewal and drug resistance via stat3/nanog signaling pathway. | hepatitis b virus (hbv) is a major risk factor of chronic liver disease and hepatocellular carcinoma (hcc). random integration of hbv dna into the host genome is frequent in hcc leading to truncation of the hbv dna, particularly at the c-terminal end of the hbv x protein (hbx). c-terminally truncated hbx (hbx-δc) has been implicated in playing a pro-oncogenic role in hepatocarcinogenesis. however, the mechanism whereby hbx-δc1 contributes to hepatocarcinogenesis remains unclear. in this study, w ... | 2017 | 28186991 |
| hepatitis b virus x protein-mediated non-coding rna aberrations in the development of human hepatocellular carcinoma. | hepatitis b virus (hbv) has an important role in the development of human hepatocellular carcinoma (hcc). accumulated evidence has shown that hbv-encoded x protein (hbx) can induce both genetic alterations in tumor suppressor genes and oncogenes, as well as epigenetic aberrations in hcc pathogens. non-coding rnas (ncrnas) mainly include micrornas and long non-coding rnas (lncrnas). although ncrnas cannot code proteins, growing evidence has shown that they have various important biological functi ... | 2017 | 28186085 |
| pharmaceutical approval update. | prasterone (intrarosa) for the treatment of dyspareunia due to menopause; crisaborole (eucrisa) for the topical treatment of atopic dermatitis; and tenofovir alafenamide (vemlidy) for once-daily treatment of chronic hepatitis b virus infection. | 2017 | 28163553 |
| rapid deterioration of latent hbv hepatitis during cushing disease and posttraumatic stress disorder after earthquake. | reactivation of the hepatitis b virus (hbv) is a risk in the 350 million hbv carriers worldwide. hbv reactivation may cause hepatocellular carcinoma, cirrhosis, and fulminant hepatitis, and hbv reactivation accompanied with malignant tumor and/or chemotherapy is a critical problem for patients with chronic hbv infection. multiple risk factors causing an immunosuppressive state can also induce hbv reactivation.we present a case of hbv reactivation during an immunosuppressive state caused by cushi ... | 2017 | 28183144 |
| ultrasensitive detection of serum hepatitis b virus by coupling ultrafiltration dna extraction with real-time pcr. | a simple and reliable dna extraction of hepatitis b virus (hbv) is critical in developing an ultrasensitive detection method for hbv infection. current commercially available serum hepatitis b virus (hbv) dna extraction methods are time-consuming, expensive and/or require specialized equipment, which hinders wide adoption of clinical laboratories. this study offers a report on an ultrasensitive hbv dna detection method by coupling serum hbv dna extraction by ultrafiltration (uf) with real-time p ... | 2017 | 28182626 |
| chronologic changes in serum hepatitis b virus dna, genotypes, surface antigen mutants and reverse transcriptase mutants during 25-year nationwide immunization in taiwan. | we investigated breakthrough infection and hepatitis b virus (hbv) genetic changes in immunized subjects after 25 years of a universal infant immunization. specifically, serum hbv dna, genotypes, surface antigen mutants and nucleoside analog-resistant (nar) mutants were assessed in 2853 subjects (<25 years old) surveyed in 2009, and these data were compared with the data from previous serosurveys. a comparison across different age-stratified groups using the 2009 data revealed a significant incr ... | 2017 | 28182307 |
| hepatitis b virus covalently closed circular dna homeostasis is independent of the lymphotoxin pathway during chronic hbv infection. | current treatment options for patients with chronic hepatitis b virus (hbv) infection are not curative as they are not effective in eliminating covalently closed circular dna (cccdna). cccdna is a stable template for hbv transcription in the nucleus of hepatocytes and is thought to be one of the main factors responsible for hbv persistence. recently, activation of the lymphotoxin beta receptor (ltβr) has been shown to trigger degradation of cccdna through induction of cytidine deaminases of the ... | 2017 | 28182305 |
| high expression of akr1b10 predicts low risk of early tumor recurrence in patients with hepatitis b virus-related hepatocellular carcinoma. | to clarify the relationship between aldo-keto reductase family 1 member b10 (akr1b10) expression and early hepatocellular carcinoma (hcc) recurrence, this study detected akr1b10 expression in tumor and adjacent non-tumor tissues from 110 patients with hepatitis b virus (hbv)-related hcc underwent liver resection and analyzed its correlations with clinicopathological characteristics and prognosis of these patients. detected by quantitative reverse transcription polymerase chain reaction, akr1b10 ... | 2017 | 28181486 |
| hepatitis b virus infection in undocumented immigrants and refugees in southern italy: demographic, virological, and clinical features. | the data on hepatitis b virus (hbv) infection in immigrants population are scanty. the porpoise of this study was to define the demographic, virological, and clinical characteristics of subjects infected with hbv chronic infection in a cohort of immigrants living in naples, italy. | 2017 | 28179020 |
| hepatitis b virus surface proteins accelerate cholestatic injury and tumor progression in abcb4-knockout mice. | understanding of the pathophysiology of cholestasis associated carcinogenesis could challenge the development of new personalized therapeutic approaches and thus improve prognosis. simultaneous damage might aggravate hepatic injury, induce chronic liver disease and even promote carcinogenesis. we aimed to study the effect of hepatitis b virus surface protein (hbsag) on cholestatic liver disease and associated carcinogenesis in a mouse model combining both impairments. hybrids of abcb4-/- and hbs ... | 2017 | 28178654 |
| clinical characteristics and prognosis of non-b, non-c hepatocellular carcinoma: the impact of patient sex on disease-free survival - a retrospective cohort study. | the number of patients with hepatocellular carcinoma (hcc) negative for both hepatitis b virus surface antigen (hbsag) and hepatitis c virus antibody (hcvab) has increased recently. the purpose of the present study was to investigate the clinical characteristics and prognoses of non-b non-c hcc (nbnc-hcc) patients. | 2017 | 28159713 |