Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [dynamics examination of eliminating surface antigen of hepatitis b virus (hbsag) and its significance for the prognosis of the disease and the carrier state (author's transl)]. | 1978 | 149606 | |
| [antibodies against the superficial component of hepatitis b virus of health workers (author's transl)]. | 1978 | 153795 | |
| [current views on the pathogenesis of hepatitis b virus infection]. | 1979 | 155247 | |
| [cloning of the hepatitis b virus genome in escherichia coli]. | the whole genome of the hepatitis b virus (dane particles) was inserted in vitro in the genome of the bacteriophage lambda gtwes . lambda b. the recombinant dna molecule was cloned in e. coli. amplification of the hybrid bacteriophage enables the preparation of large amounts of hepatitis b virus dna. the possibilities offered by the utilization of this recombinant bacteriophage are discussed. | 1978 | 158442 |
| fulminant hepatic failure during remission from leukemia: three cases associated with massive liver cell necrosis and hepatitis b virus. | three patients at various stages of remission from leukemia died following the development of massive liver necrosis within only 4-6 days. all had either hepatitis b surface antigen or antibody in their sera, and two of them experienced severe epigastric pain before the onset of liver injury. hepatitis b surface antigen appeared in two of these patients after remission from leukemia. serum gamma-globulin levels increased with decreasing doses of prednisolone and other antileukemic drugs, and hep ... | 1979 | 158950 |
| [occurrence and spreading of hepatitis b virus according to its immunochemical markers (author's transl)]. | 1979 | 159136 | |
| viral hepatitis, type a. identification by specific complement fixation and immune adherence tests. | hepatitis a antibody was detected by specific immune adherence and complement-fixation tests in a study involving 473 serum specimens from 20 patients who had viral hepatitis, type a. in all 20 patients who had no detectable immune adherence antibody (less than 1:5) before onset of hepatitis high levels (greater than or equal to 1:1024) developed one to four weeks later, occasionally reaching peak levels exceeding greater than or equal to 1:81,920 several months thereafter. five to 10 years late ... | 1975 | 164627 |
| physical, chemical and morphologic dimensions of human hepatitis a virus strain cr326 (38578). | cr326 human hepatitis a virus purified by isopycnic banding from infected marmoset sera was shown to consist of 27 nm spherical particles on electron microscopic examination. the particles were identified as hepatitis a virus by tests for infectivity and by specific neutralization of infectivity with convalescent human hepatitis a serum. also, indentical 27 nm viruses in liver extracts gave specific reactions with hepatitis a antisera when tested by immune electron microscopy. the bouyant den ... | 1975 | 164674 |
| a specific complement-fixation test for human hepatitis a employing cr326 virus antigen. diagnosis and epidemiology. | a specific diagnostic complement-fixation test for hepatitis a antibody in human serum was described employing livers of marmosets infected with cr326 strain human hepatitis a virus. persons with hepatitis a, but not hepatitis b, developed hepatitis a cf antibody shortly after the onset of illness and this persisted thereafter. good agreement was noted in the development of cf and neutralizing antibodies in hepatitis a cases. hepatitis a was shown to occur in a person with hepatitis b antigenemi ... | 1975 | 165548 |
| hepatitis types b and non-b. epidemiologic background. | two episodes of acute viral hepatitis occurred in each of 34 patients. one episode in each patient was serologically diagnosable as type b hepatitis on the basis of tests for hepatitis b surface antigen or antibody. the other episode was classified as "non-b" on the basis of seronegativity, reinforced by seropositivity in an alternate bout. an epidemiologic background appropriate to "serum" hepatitis, either transfusion (one bout) or illicit self-injection (46 bouts), was associated just as freq ... | 1975 | 168417 |
| hepatic dysfunction in recipients of renal allografts. | 1975 | 168654 | |
| viral hepatitis--1975. | 1975 | 169401 | |
| viral hepatitis. | 1975 | 169519 | |
| viral causes of hepatitis. | 1975 | 169635 | |
| clinical and pathological findings and sequelae of viral hepatitis. | 1975 | 169636 | |
| clinical aspects of viral infections in kidney-graft recipients. | 1975 | 170042 | |
| epidemiology of cytomegalovirus infection after transplantation and immunosuppression. | viral infections and clinical complications were studied during hemodialysis and after renal transplantation. active cytomegalovirus infection developed in 96% of patients after renal transplantation; reactivation of herpes simplex, varicella-zoster, and epstein-barr viruses was found in 35%, 24%, and 0% of patients, respectively. cytomegalovirus viremia developed in 42% of patients an average of two months after renal transplantation, lasted 1.75 (+/- 1.5) months (except in one patient with chr ... | 1975 | 171315 |
| viral hepatitis: recent developments and prospects for prevention. | during the past decade new development in hepatitis research have shed new light on the etiologic, epidemiologic, immunologic, and prophylactic aspects of type a and b hepatitis virus infection. recent advances in hepatitis a virus research include: (1) identification of the virus as a 27 nm particle with characteristics resembling an enterovirus, (2) transmission of the infection to marmosets and chimpanzees, and (3) development of specific complement fixation and immune adherence antibody test ... | 1975 | 171363 |
| evidence for viral hepatitis other than type a or type b among persons in costa rica. | in studies of hepatitis in an endemic zone in costa rica, 103 patients were examined for antibodies against hepatitts a by the immune-adherence assay, for hepatitis b antigen and its antibody by radioimmunoassay and passive hemagglutination, respectively, and for antibodies against cytomegalovirus by complement fixation. twelve cases were encountered in which both type a and type b hepatitis could be excluded on the basis of serologic testing. in all but one of these 12 patients, cytomegalovirus ... | 1975 | 171577 |
| viral hepatitis: a pathologic spectrum. | acute viral hepatitis has several identifiable morphologic components but the major categories are (1) cytopathic, (2) inflammatory, and (3) regenerative. each category has independently variable characteristics. extreme alterations related to severity of disease, alteration of immune response, or pre-existing liver disease may result in diagnostic difficulties for the pathologist. in contrast to the usual concept, patients who survive fulminant viral hepatitis rarely, if ever, develop cirrhosis ... | 1975 | 171949 |
| viral hepatitis on the threshold of control. | 1975 | 171950 | |
| discussion. viral hepatitis: the disease. | 1975 | 171952 | |
| biophysical and biochemical properties of cr326 human hepatitis a virus. | cr326 human hepatitis a virus purified by isopycnic banding from infected marmoset sera was shown to consist of 27 mmu spherical particles on electron microscopic examination. the particles were identified as hepatitis a virus by tests by infectivity and by specific neutralization of infectivity with convalescent human hepatitis a serum. also, identical 27 mmu viruses in liver extracts gave specific reactions with hepatitis a antisera when tested by immune electron microscopy. the buoyant densit ... | 1975 | 171955 |
| viral hepatitis: clinical aspects. | in the majority of instances acute viral hepatitis resolves totally without sequelae. fulminant hepatitis is a highly lethal lesion but 20 to 25 per cent of patients, principally young patients, survive. survivors do not appear to develop chronic liver disease. persistent viral hepatitis follows acute icteric hepatitis, both type b and non-b, in 10 to 12 per cent of patients. six long-term hbs ag carriers demonstrated hbs ag clearance after 14-73 months. chronic active viral hepatitis often prog ... | 1975 | 171956 |
| etiological spectrum of post-transfusion hepatitis. | frequent occurrence of post-transfusion hepatitis continues despite screening for australia antigen in blood before transfusion and elimination of commercial donor sources. the majority of these cases appears unrelated to hepatitis b virus. preoperative, acute, and convalescent serra were screened for evidence of hepatitis b, hepatitis a, epstein-barr, and cytomegalovirus exposure in 34 cardiac surgery patients developing post-transfusion hepatitis postoperatively. four patients showed evidence ... | 1975 | 172400 |
| lymphocyte e rosette inhibitory factor: a regulatory serum lipoprotein. | rosette inhibitory factor, rif, previously described in serum from patients with hepatitis b virus infection, has been isolated and identified as a minor species of beta-lipoprotein of the low-density (ldl) class. it is unrelated to hepatitis b virus proteins or particles. although discrete by reference to charge and density (1.050 +/- 0.004 g/cm3), rif appears to be a complex macromolecular structure containing apolipoproteins a, b, and c. greater than 400% recovery is achieved upon 300,000-fol ... | 1975 | 172585 |
| [viral hepatitis a and b]. | 1975 | 172831 | |
| current concepts of acute and chronic viral hepatitis. | 1975 | 172845 | |
| causes of death in fulminant hepatic failure and relationship to quantitative histological assessment of parenchymal damage. | the clinical course and causes of death in 132 consecutive patients with fulminant hepatic failure and grade iii or iv encephalopathy have been reviewed. 105 patients died and in 96 of these an autopsy examination was performed. in 36 patients there was cerebral oedema and the mean age of this group was significantly younger than the other fatal cases. in 28 patients death was attributed to major haemorrhage which originated in the gastrointestinal tract in 25. the prothrombin time ratio was not ... | 1975 | 172938 |
| immunodeficiency to hepatitis b virus infection and genetic susceptibility to development of hepatocellular carcinoma. | the high frequency of hepatitis b antigen (hbsag) in hepatocellular carcinoma (hcc) patients has led to the hypothesis that immunoresponsiveness to hepatitis b virus (hbv) may be deficient in some patients, and that the immune response deficiency may have a genetic basis. radioelectrocomplexing (rec), a radioimmunoassay in gel based on the principle of counterimmunoelectrophoresis (cie), has been used to identify four hbv immune status subgroups: 1) hbsag +ve/hbsab +ve; 2) hbsag +ve/hbsab -ve; 3 ... | 1975 | 173228 |
| infectivity studies of hepatitis a and b in non-human primates. | we have induced hepatitis a in marmosets of the subspecies saguinus mystax following primary inoculation with human serum containing the ms-1 strain of hepatitis a virus (hav) and in 3 further marmoset subpassages using infective marmoset serum from each preceding passage. in each passage acquisition of serum antibody against 17 nm virus-like particles recovered from acute illness stools of human volunteers who developed hepatitis following inoculation with the ms-1 strain of hav, as well as fro ... | 1975 | 173599 |
| characterization of cr326 human hepatitis a virus, a probable enterovirus. | cr326 human hepatitis a virus purified by isopycnic banding from infected marmoset sera was shown to consist of 27 mmu spherical particles on electron microscopic examination. the particles were identified as hepatitis a virus by tests for infectivity and by specific neutralization of infectivity with convalescent human hepatitis a serum. also, identical 27 mmu viruses in liver extracts gave specific reactions with hepatitis a antisera when tested by immune electron microscopy. the buoyant densi ... | 1975 | 173603 |
| tropical cirrhosis and hepatoma. | 1976 | 173844 | |
| acute viral hepatitis. | 1976 | 173971 | |
| hepatitis: two elusive viruses. | 1976 | 174064 | |
| viral hepatitis--a primer: 1. epidem.iology. | hepatitis a is most often transmitted by the fecal-oral route under conditions of crowding, poor hygiene, and prolonged exposure to infected persons. direct spread of hepatitis b via person-to person contact has only recently been proved. hepatitis b is usually transmitted indirectly proved. hepatitis b is usually transmitted indirectly by percutaneous routes, and the increase in drug abuse has brought about a change in its epidemiologic pattern. | 1976 | 174067 |
| the relation of infection with the hepatitis b agent to primary hepatic carcinoma. | in asia, africa, and other tropical areas, primary hepatic carcinoma (phc) is associated with liver cirrhosis of the postnecrotic (macronodular) type. chronic viral hepatitis is likely to be the cause of this cirrhosis in many patients from regions where chronic infection with the hepatitis b virus (hbv) is common. more than 95% of patients with hepatoma (in mali and senegal) have evidence of infection with hbv, a much higher frequency than in controls. thirty-nine of 62 patients with phc had he ... | 1975 | 174434 |
| [pathogenic and therapeutic concepts in viral hepatitis]. | 1976 | 175890 | |
| the seroepidemiology of reovirus, coxsackievirus infections among panamanian indian children. | rates of hepatitis b virus infection varied significantly among panamanian indian tribes. chocó and mainland cuna indians had a greater prevalence of antibody to hepatitis b surface antigen than guaymi and island cuna indians. the village water supply appeared to be the major environmental difference that distinguished the tribes from one another. since contaminated water plays a role in the transmission of enterovirus, an attempt was made to assess relative exposure to contaminated water by det ... | 1976 | 176278 |
| [laboratory diagnostic differences between hepatitis a and hepatitis b]. | 1976 | 177254 | |
| [hospital-acquired hepatitis type b. report of 6 cases (author's transl)]. | seroconversion was observed in 6 patients, indicating an infection with hepatitis virus b. all of these patients had been hospitalized with hbag-positive persons a few weeks before, 5 of them because of acute hepatitis type a. while seroconversion was followed by acute hepatitis in 4 cases, the infection remained clinically silent in the other two patients. the second periods of illness were no attacks of relapsing hepatitis type a, as was indicated by hbag. vice versa superinfection of hepatiti ... | 1976 | 177849 |
| viral infections that affect the fetus. | several viral infections besides rubella are known to cause fetal anomalies and disease. cytomegalovirus, for example, may adversely affect the fetus in a number of ways. either herpesvirus or hepatitis b virus is transmissible from mother to offspring. viruses whose potential for fetal harm is less clear are those of varicella, mumps, and influenza. | 1976 | 177962 |
| intranuclear virus-like particles in hbsag- and ihxag-negative acute hepatitis (type c?) (preliminary report). | virus-like particles, acute hepatitis, hepatitis type c. intranuclear virus-like particles were found by electron microscopy in liver cells of a woman suffering from mild hbsag- and ihxag negative acute hepatitis. the particles encountered were morphologically different from those found in hepatitis b and hepatitis a respectively. futher studies are required to clarify whether the structures represent an incidental finding of a new human (passenger) virus or they may be related to the aetiologic ... | 1975 | 180761 |
| infectious particles in hepatitis. | 1976 | 180873 | |
| the economic impact of viral hepatitis in the united states. | 1976 | 181777 | |
| hepatitis a antigen isolated from liver and stool: immunologic comparison of antisera prepared in guinea pigs. | morphologically similar hepatitis a antigen particles (ha ag)3 have been detected in the stools of patients with type a hepatitis and in the livers of marmosets experimentally infected with hepatitis a virus. to investigate the humoral antibody responses to these antigens and to compare the immunologic properties of ha ag from these two sources, we immunized guinea pigs with either marmoset liver-derived ha ag or with human stool-derived ha ag in complete freund's adjuvant and measured their ant ... | 1976 | 182882 |
| distribution of antibody to hepatitis a antigen in urban adult populations. | to investigate the prevalence and distribution of antibody to hepatitis a antigen we tested 947 randomly selected people in the greater new york city area; 45 per cent were antigen positive, as determined by the immune adherence method. antibody was detected two to three times more frequently in lower social classes (72 to 80 per cent) than in middle and upper-middle classes (18 to 30 per cent). the rate of antibody detection was strongly correlated with age; the prevalence gradually increased t ... | 1976 | 183113 |
| [development of cellular immunity in patients with viral hepatitis]. | the development of cell-mediated immunity (cmi) to the surface antigen of hepatitis b virus (hbsag) and botevgrad antigen (ba) was traced in 50 hepatitis patients. migration inhibition test (mit) was performed with purified hbsg and ab. blood samples from every hepatitis patient were obtained at the beginning of the icteric phase, 10 days later and during convalescence. there was correlation between the two types of viral hepatitis and the type of cellular immune response. the development of cmi ... | 1976 | 185810 |
| mutliple hepatitis viruses in multiple attacks of acute viral hepatitis. | we evaluated the causes of 30 episodes of acute viral hepatitis in 13 patients who had multiple attacks. two (seven per cent) of 30 bouts were caused by hepatitis a virus, and 12 (40%) by hepatitis b virus. no patient, however, had more than one attack with the serologic characteristics of type a or type b disease. thus, there were 16 bouts (53 per cent) not attributable to either of the two recognized hepatitis viruses. none of these "non-a, non-b" episodes, evaluated for infectious mononucleos ... | 1977 | 186710 |
| hepatitis b virus, cirrhosis and primary carcinoma of the liver. an electron microscopic study. | the core and coat of hepatitis b virus were found by electron microscopy in parenchymal cells of a liver biopsy from a 61 year old man with chronic active hepatitis and cirrhosis of the liver. laparoscopy, 35 days after liver biopsy, and autopsy 42 days later confirmed the cirrhosis and showed in addition a well differentiated hepatoma. the possibility of a viral aetiology for the cirrhosis and primary carcinoma of the liver is considered. | 1976 | 188267 |
| hepatoma and hepatitis b virus. | 1977 | 188786 | |
| hepatitis ain greenland: importance of specific antibody testing in epidemiologic surveillance. | an epidemic of viral hepatitis type a in an arctic area is described. from 1970-1974, 4961 clinical cases of hepatitis were reported in greenland, corresponding to 11 per cent of the total population. epidemiologic surveillance indicated person-to-person transmission of the disease, apparently by the oralfecal route. the course of the disease was mild, and complications were rare with a case fatality rate of 0.3%. ninety-three per cent of the cases occurred in individuals 1-25 years of age, sugg ... | 1977 | 189600 |
| cellular localization of hepatitis b virus antigens in patients with hepatocellular carcinoma coexisting with liver cirrhosis. | specimens of liver tissue obtained by biopsy from five patients and at necropsy from seven patients with postnecrotic liver cirrhosis and hepatocellular carcinoma were examined for the presence of hepatitis b surface antigen (hbs ag) and hepatitis b core antigen (hbc ag) by direct immunofluorescence. in all cases, samples of serum were tested for hbs ag and antibody to hbs ag (anti-hbs) by immunoelectroosmophoresis and for antibody to hbc ag (anti-hbc) by indirect immunofluorescence. of these 12 ... | 1977 | 190331 |
| [the relation of infection with the hepatitis b-agent to primary hepatic carcinoma (author's transl)]. | in asia, africa and other tropical areas primary hepatic carcinoma (phc) is associated with liver cirrhosis of the post-necrotic (macronodular) type. chronic viral hepatitis is likely to be the cause of this cirrhosis in many patients from regions where chronic infection with the hepatitis b virus (hbv) is common. more than 95% of patients with hepatoma (in mali and senegal) have evidence of infection with hbv, a much higher frequency than in controls. thirty-nine of 62 phc patients had hepatiti ... | 1976 | 190499 |
| a prospective study of acute viral hepatitis with particular reference to hepatitis a. | in order to investigate the relationship of hepatitis a antigen to viral hepatitis, a prospective study was carried out on 97 patients admitted to fairfield hospital, melbourne, with suspected viral hepatitis, and 3 of their family contacts. evidence of infection with hepatitis a virus was obtained by detecting hepatitis a antigen in stools, and/or antibody to it in sera, by immune electron microscopy. infection with hepatitis b virus was determined by testing for hepatitis b surface antigen and ... | 1976 | 191207 |
| anti-hbc titer in relation to the etiological role of hepatitis b virus in primary hepatocellular carcinoma. | the antibody to hepatitis b core antigen (anti-hbc) is belived to be a marker for natural infection with hepatitis b virus (hbv). in order to study the etiological role of hbv in relation to primary hepatocellular carcinoma (phc), the anti-hbc in sera of 31 phc patients was surveyed by the immune adherence hemagglutination method which was about 10 times more sensitive than the complement fixation method. twenty two out of 31 phc cases were positive for anti-hbc (71.0%). the is a higher rate of ... | 1977 | 192028 |
| viral hepatitis: some thoughts and a summary. | 1975 | 192078 | |
| antibody to hepatitis b core antigen in patients with hepatocellular carcinoma. | hepatitis b surface antigen (hbsag), anti-hbs, and anti-hb core (hbc) were measured in 124 patients with hepatocellular carcinoma (hcc) in comparison with 299 control subjects of comparable ages, and in 48 cases of chronic hepatitis and 52 cases of hepatic cirrhosis. it was found that 72.6% of the hcc patients were positive for anti-hbc, and 80.6% were positive for at least one test, whereas in the control, anti-hbc was positive in 30.1% and 34.1% were positive for at least one test, the differe ... | 1977 | 192626 |
| hepatitis b virus infection and primary hepatocellular carcinoma. | ninety-three patients with biopsy-proven primary hepatocellular carcinoma (phc) from uganda, zambia, and the united states were examined for serologic evidence of hepatitis b virus (hbv) infection. patients were tested for hepatitis b surface antigen (hbsag) and its antibody (anti-hbs), antibody to the hepatitis b core antigen (anti-hbc), hepatitis b e antigen (hbeag), and its antibody (anti-hbe). active hbv infection, as indicated by positive tests for hbsag (with or without anti-hbs) and anti- ... | 1977 | 192895 |
| acute viral hepatitis: modern knowledge. | 1977 | 193084 | |
| advances in viral hepatitis. report of the who expert committee on viral hepatitis. | 1977 | 193307 | |
| transmission of non-a, non-b hepatitis. | in studies conducted in the early 1950s, sera from six asymptomatic blood donors, implicated in the transmission of viral hepatitis, were inoculated into 10 to 20 volunteers each. five of these "implicated" donor sera transmitted clinically apparent hepatitis to the recipients. the stored serum samples from these studies have been reanalyzed using serologic markers for hepatitis b virus and hepatitis a virus infection. two of the donor sera were hepatitis b surface antigen (hbsag)-positive, and ... | 1977 | 195505 |
| parenterally transmitted non-a, non-b hepatitis: an epidemic reassessed. | in 1972 a nonsocomial outbreak of parenterally transmitted hepatitis affected both marrow transplant patients and normal platelet donors in an oncology unit. because of the characteristics of the clinical illness, the incubation period of 27 days, and the effect of immune serum globulin on the clinical illness, the outbreak was attributed to hepatitis a; there was no serologic evidence of either hepatitis b virus or cytomegalovirus infection. stored serums from this outbreak were re-examined by ... | 1977 | 195506 |
| recent advances in the identification of hepatitis viruses. | resulting directly from the discovery of virus-related antigens, rapid progress has marked the last decade of viral hepatitis research. the hepatitis b virion has been tentatively identified as a dna virus with an endogenous dna polymerase, and new serological markers for type b hepatitis have been discovered. hepatitis a antigen has been identified on a virus-like particle thought to be the hepatitis a virion. progressively more sophisticated assays for hepatitis antigens and antibodies have be ... | 1977 | 196274 |
| geographical distribution of the subtype of hepatitis b surface antigen in chinese. | using the much more sensitive hemagglutination inhibition assay for subtyping of hepatitis b surface antigen (hbsag), we examined the determinants a, d, w and r in 192 from 228 hbsag positive adults who had been found after screening with reversed passive hemagglutination method. sixty-four subtypable cases were asymptomatic carriers and the remaining 128 were liver disease patients. among them there was no significant difference of the subtypes, invariably with adw as the main subtype. geograph ... | 1977 | 196971 |
| experimental carcinoma of liver in macaque monkeys exposed to diethylnitrosamine and hepatitis b virus. | the effects of treatments with diethylnitrosamine (dena) and hepatitis b virus (hbv) on macaque monkeys were investigated by virus serology and by light and electron microscopy. the experimental groups comprised 43 newborn or juvenile cynomolgus and rhesus monkeys of both sexes. hbv neither had a carcinogenic effect nor increased the oncogenic effect of dena. however, hbv given to juvenile primates before treatment with dena resulted in subsequent gross and microscopic alterations consistent wit ... | 1977 | 198564 |
| [core and coat of the hepatitis b-virus and cytoplasmic viruslike particles in chronic hepatitis. an electron microscopic study (author's transl)]. | in the second liver biopsy material of a seropositive patient receiving immunosuppressive therapy (corticosteroid + imuran) for chronic active hepatitis (cah), intranuclear, ring-shaped, 20--25 nm in diameter non-coated particles (core) of liver cells and intracisternal filaments, 23 nm in diameter (coat) of the soft er in the "ground-glass" hepatocytes were demonstrated by electron microscopy. core-particles in the cytoplasm were seen occasionally. dane-particles could not be visualized. cytopl ... | 1977 | 200036 |
| hepatocellular carcinoma and chronic persistent hepatitis. | the morphologic type of cirrhosis that is followed most frequently by hepatocellular carcinoma is posthepatitic cirrhosis. furthermore, hb ag is detected in a high rate among cases with hepatocellular carcinoma suggesting the intimate causal relationship between hepatitis b virus and hepatocellular carcinoma. it has been considered that hepatocellular carcinoma might develop during destruction and regeneration of fully developed liver cirrhosis. however, hepatocellular carcinoma is combined with ... | 1977 | 200057 |
| viral hepatitis: enzyme assays and serologic procedures in the study of an epidemic. | an epidemic of viral hepatitis beginning in late 1975 in a residence for multiply handicapped children, recognized very early in its course, was investigated prospectively to permit comparison of enzymatic and serologic tests. thirty-three residents of the institution and 46 full- and part-time employees were studied by the immune adherence hemagglutination procedure for antibody (anti-hav) to hepatitis a virus (hav). of these, 31 residents and 37 staff members were susceptible at the beginning ... | 1977 | 201170 |
| the relationship between hepatitis b virus infection and hepatic cell carcinoma in mozambique. | hepatitis b surface antigen and antibody were sought in sera collected from patients with hepatic cell carcinoma and from healthy blood donors. the frequency of the antigen among the patients was significantly higher than that among blood donors who served as controls (p = less than .01) but no significant difference was found in estimated exposure to hepatitis b virus between hepatic cell carcinoma patients and african blood donors. however, exposure to hepatitis b virus was significantly less ... | 1977 | 202048 |
| failure to transmit human viral hepatitis types a and b to the congenitally athymic nude mouse. | 1977 | 202797 | |
| benign and malignant liver neoplasms: some new etiologic associations. | several agents have recently been implicated in the development of benign and malignant liver neoplasms. recognition of their possible role by the primary care physician may prevent serious consequences to patients exposed to these agents, which include oral contraceptives, androgens, hepatitis virus, and vinyl chloride. | 1978 | 203904 |
| hepatocellular carcinoma and hepatitis b. | 1977 | 204083 | |
| the immunology of the hepatitis viruses. | 1978 | 204170 | |
| hepatitis a virus infection: new insights from seroepidemiologic studies. | the prevalence of exposure to hepatitis a virus (hav) increases with increasing age; decreases with increasing socioeconomic class; increases with increasing serologic evidence of prior hepatitis b virus (hbv) exposure but is much more common than hbv exposure; is independent of sex and race; varies in different parts of the world as a function of hygienic, developmental, and unrecognized geographic factors; and is not affected by immune deficiency or immaturity. transmission of type a hepatitis ... | 1978 | 204711 |
| viral hepatitis. | 1978 | 205734 | |
| acute viral hepatitis. | it is now possible to define two forms of acute viral hepatitis by means of specific serological tests and at least one other form by exclusion. these diseases are known as hepatitis a, hepatitis b and non a non b hepatitis respectively. major features of the virology, pathogenesis, laboratory diagnosis, epidemiology, mode of spread and control of each disease are briefly reviewed. | 1978 | 208497 |
| human studies following models of tumorigenesis by dna tumor viruses in animals. | the discovery of virus-specific messenger rna in virus-induced animal tumors has led to the search for messenger rna in human tumors that can be hybridized with the dna of known oncogenic viruses. attention has focused on the adenoviruses, which have produced cancer in laboratory animals and are widespread in man, and on three papovaviruses that have been isolated in human disease and which are oncogenic in hamsters. in other research, the association between human infection with herpesivurs typ ... | 1978 | 208690 |
| research into the cause, diagnosis and treatment of primary liver cancer. | 1975 | 209447 | |
| [nature of type a and type b hepatitis viruses and their diagnosis and control]. | 1978 | 209504 | |
| [viral hepatitis which is not caused by hepatitis virus]. | 1978 | 209527 | |
| transfusion-related short-incubation hepatitis in hemophilic patients. | nine episodes of a unique short-incubation form of hepatitis were observed during five years in six hemophilic children after infusion with commercial factor viii concentrate prepared by two different manufacturers. five patients with a single episode had no previous infusion for 14 months to 14 years. one patient with several episodes had no previous infusion for at least seven months preceding each episode. the illness was mild and self-limited. no seroconversions to cytomegalovirus, epstein-b ... | 1978 | 210302 |
| non-a, non-b hepatitis. | 1978 | 210303 | |
| clustering of different subtypes of hepatitis b surface antigen in families of patients with chronic liver diseases. | clustering of hepatitis b surface antigen (hbsag) with both subtypes adr and adw in three families of patients with chronic liver diseases or hepatocellular carcinoma was demonstrated in taiwan where adw is the main subtype. the subtype in the children was similar to that in their mothers, suggesting maternal transmission. in all the family units clustered with different subtypes, the same pattern occurred, invariably with fathers carrying hbsag/adr and the children carrying hbsag/adw. the subty ... | 1978 | 210659 |
| viral hepatitis--a triumphant triennial. | 1978 | 210661 | |
| incidence and significance of hepatitis b e antigen and antibody in postnecrotic cirrhosis and primary hepatocellular carcinoma. | a study of the serological markers of hepatitis b virus (hbv) including e antigen (hbe ag) and antibody against hbe ag (anti-hbe) was performed in senegalese patients suffering from cirrhosis and primary hepatocellular carcinoma, and in a control group (blood donors). it was not possible to diagnose additional hbv infections in primary hepatocellular carcinoma patients using hbe ag or anti-hbe ab alone as serological markers. the lower prevalence of hbe ag among primary hepatocellular carcinoma ... | 1978 | 211144 |
| [etiology and epidemiology of viral hepatitis]. | 1977 | 211575 | |
| hepatitis b virus dna in primary hepatocellular carcinoma tissue. | tumour, cirrhotic, and metastatic tissues from four patients with primary hepatocellular carcinoma have been investigated for the presence of hepatitis b viral dna by nucleic acid hybridization. tumours from two of three patients with a current hbv infection contained 1--2 genomes per cell of unintegrated viral dna, while tumours from the third hbs antigen-positive patient contained less than one genome equivalent per ten cells. a tumour from one patient with anti-hbs contained no detectable hbv ... | 1978 | 212525 |
| a virus similar to human hepatitis b virus associated with hepatitis and hepatoma in woodchucks. | particles with properties similar to those associated with human hepatitis b were found in serum from woodchucks with chronic hepatitis and hepatocellular carcinoma. it is suggested that woodchuck hepatitis virus is a second member of a novel class of viruses represented by the human hepatitis b virus. | 1978 | 212758 |
| hepatocellular carcinoma and the hepatitis b virus: evidence for a causal association. | 1978 | 212785 | |
| serologic markers of hepatitis a and b in chronic active hepatitis. | sera from 44 patients with a well-documented diagnosis of chronic active hepatitis (cah) were analysed for antibodies to hepatitis a virus (anti-hav), hepatitis b surface antigen (hbsag) and anti-hbs, e-antigen (hbeag) and anti-hbe, as well as antibodies to hepatitis b core antigen (anti-hbc). twenty-two patients had serologic evidence of hepatitis a infection. the frequency of anti-hav was low in patients under 50 years of age (21%) but high among older patients (72%). there was, however, no si ... | 1978 | 212821 |
| prospects of vaccines against cancer in man. | preventive immunization is the cheapest and most effective approach to the management of epidemic disease. certain forms of cancer, including burkitt's lymphoma, carcinoma of the cervix, primary liver cancer, acute leukaemia and breast cancer show many characteristics of epidemic disease, and the possibility of producing preventive vaccine against these conditions merits serious consideration. | 1978 | 212839 |
| [virus and human cancers]. | 1978 | 214215 | |
| hbsag-negative chronic active hepatitis related to hepatitis b virus. | numerous cases of chronic hepatitis have been shown to be closely associated with persistent infection with hepatitis b virus (hbv). a group of 100 patients suffering from chronic active hepatitis (cah) was investigated for hbv serologic markers. of these, 35 patients were hbsag-positive; in 26 hbsag-negative subjects, anti-hbc were detected using counterimmune electrophoresis and complement-fixation tests. these data suggest that chronic liver disease in patients who were only anti-hbc-positive ... | 1978 | 214684 |
| pathology and pathogenesis of viral hepatitis. | 1978 | 214873 | |
| hepatitis b virus infection and chronic liver disease in taiwan. | three hundred and eighty-five patients mostly with chronic liver diseases and 729 apparently healthy adults were studied for hepatitis b surface antigen (hbsag) with reversed passive hemagglutination and antibody (anti-hbs) with passive hemagglutination. in healthy adults around 15% was hbsag positive and in 45% was anti-hbs positive, estimating hepatitis b virus (hbv) infection in nearly two thirds of the population. the infection already occurred before adulthood. the prevalences of hbsag were ... | 1978 | 214987 |
| hepatocellular carcinoma in the u.s.a., etiologic considerations. localization of hepatitis b antigens. | the serologic and tissue markers of hepatitis b virus (hbv) were studied in 50 patients in whom hepatocellular carcinoma (hcc) was confirmed at autopsy. serologic and tissue markers included serum hepatitis b surface antigen (hbsag), tissue hbsag, tissue hepatitis core antigen (hbcag), and serum antibody to hbcag (anti-hbc). twenty-two patients had hcc arising in alcoholic cirrhosis; 2 of the 22 (9.1%) had one or more of the hbv tissue and serologic markers. this infection rate is similar to the ... | 1979 | 215488 |
| developments in viral hepatitis. | viral hepatitis is a major public health problem occurring endemically in all parts of the world. the general term viral hepatitis refers to infections caused by hepatitis virus type a, type b and a more recently identified infection referred to as "non-a: non-b" hepatitis. these clinically and pathologically similar forms of hepatitis have been studied intensively following the discovery of a specific antigen, australia antigen, one of the markers of infection with hepatitis b virus. | 1978 | 215717 |
| asymptomatic viral hepatitis types a and b in an adolescent population. | sera from 95 adolescents were examined for markers of hepatitis b virus (hbv) infection and hepatitis a virus (hav) infection. hbv markers were found in eight adolescents (8%) and evidence of previous hav infection was found in 18 adolescents (19%); none had a history of clinically recognizable hepatitis. these findings support the growing evidence that hbv and hav infections are diseases of the pediatric age group, and that testing of hbv vaccines when they become available for patient use will ... | 1978 | 215959 |
| hepatocellular carcinoma (an approach to the study of risk factors in human cancer). | risk factors can be used to formulate hypotheses on the aetiology and pathogenesis of site specific cancers. persistent infection with hepatitis b virus (hbv), chronic liver disease, and maleness are associated with a greatly increased risk of developing primary hepatocellular carcinoma (phc). a model for the pathogenesis of this tumour is proposed that does not involve integration of the hbv genome into the tumour cell. if chronic infection with hbv is necessary for the development of chronic l ... | 1978 | 216070 |