Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| a case report of primary hepatic carcinoma with prolonged hb virus infection and mono-clonal gammopathy. | a case of alpha-feto protein (afp) positive hepatic cell carcinoma has been presented in which the appearance of a mono-clonal gammopathy can be explained by persistent infection with hb virus (hbv). the patient, a fifty year old male, developed acute jaundice with hepatitis in july, 1952, and died of an hepatic cell carcinoma in december, 1973. the interest of this case lies in the fact that during the seven months prior to be patient's demise, a mono-clonal gammopathy of igg (l type), together ... | 1977 | 67980 |
| immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis b virus in liver and in serum of hbsag carriers. | a new antigen-antibody system associated with the hepatitis b virus and immunologically distinct from the hb surface, core, and e systems is reported. the new antigen, termed delta, was detected by direct immunofluorescence only in the liver cell nuclei of patients with hbsag positive chronic liver disease. at present, the intrahepatic expression of hbcag and delta antigen appears to be mutually exclusive. no ultrastructural aspect corresponding to the delta antigen could be identified under the ... | 1977 | 75123 |
| [new aspects of therapy and prophylaxis of virus hepatitis (author's transl)]. | the etiology of viral hepatitis is well known, since the hepatitis a virus and the hepatitis b virus were detected. there is, however, no specific treatment of the disease. steroids should not be used, since a therapeutical value in viral hepatitis is not definitely proven and since they may contribute to the development of chronic hepatitis. the application of hepatitis b immunoglobulin (hbig), interferon or interferon inducers in hepatitis b infections has yielded some interesting results, whi ... | 1977 | 73114 |
| forecasting the development of primary hepatocellular carcinoma by the use of risk factors: studies in west africa. | an association between hepatitis b virus (hbv) and primary hepatocellular carcinoma (phc) has been found in several studies in africa, asia, and elsewhere. in this paper we considered the interrelations between several events related to hbv infection, which include the presence of: 1) hepatitis b surface antigen (hbsag), 2) antibody to hepatitis b core antigen (anti-hbc), 3) antibody to the surface antigen (anti-hbs), 4) chronic liver disease, 5) elevated alpha-fetoprotein, and 6) phc. with the ... | 1977 | 68119 |
| hepatitis b antigen: advancement in knowledge quickens. (a review). | for many years viral hepatitis and its causative agent have been an enigma to investigators. in the last decade there has been such an increase of information on the subject that it challenges one's ability to keep abreast of the advancement in knowledge. the purpose of this paper is to bring into focus some of the latest developments with regard to viral hepatitis b and its causative agent. | 1977 | 69402 |
| anti-hbbrno: a new ciep hepatitis b marker, more sensitive than hbsag radioimmunoassay. | evidence is presented for the new hbbrnoag-anti-hgbrno system association with the hbsag. the association is displayed particularly in a prevalence of ausria detectable hbsag carriers among the anti-hbbrno carriers, suggesting the anti-hbbrno to be a marker of contact with hepatitis b or, possibly, an indicator of co-existing hbsag antigenaemia, not detectable by radioimmunoassay. identity of hbbrnoag with hbsag/a, d, y, w, is ruled out, the identity with the other hbv associated antigenic speci ... | 1977 | 69570 |
| expression of hepatitis b virus-specific markers in asymptomatic hepatitis b surface antigen carriers. | a study was undertaken to assess the state of hepatitis b virus infection in a group of asymptomatic hepatitis b surface antigen (hbsag) carriers. this study confirmed that the presence of hepatitis b e antigen (hbeag) in serum was closely associated with serum hbsag-specific deoxyribonucleic acid polymerase activity, hepatitis b core antigen (hbcag) in serum and liver cell nuclei, and a histological picture of chronic hepatitis. no hbsag-specific deoxyribonucleic acid polymerase activity or hbc ... | 1977 | 71267 |
| anti-e and rheumatoid factor. | 1977 | 71433 | |
| incidence of hbe antigen and hbe antibody in blood-donors. | 1977 | 71584 | |
| the demonstration of subtype (d or y)-specific determinants on the surface of the presumed hepatitis b virus. | dane particles isolated from the sera of hbsag/ad and hbsag/ay carriers were reacted with monospecific antibodies to the d and y subtype-specific determinants of hbsag/. dane particles from hbsag/ad expressed the d determinant on their surfaces and those from hbsag/ay sera contained the y specificity. both complete (dna-p and hbcag) and defective (hbcag alone) dane particles expressed the subtype-specific determinants. | 1977 | 70490 |
| [hepatitis b virus and primary liver carcinoma: evidences for a filiation hepatitis b, cirrhosis and primary liver cancer]. | many arguments have been developed for a filiation hepatitis b, cirrhosis and primary liver cancer (plc). the hypothesis in favour of the hepatitis b virus (hbv) as an indirect agent of plc was supported by epidemiological and anatomo-clinical data. the study of the serological markers of hbv has been performed in groups of senegalese patients who were suffering from hepatitis b, cirrhosis or plc and two control groups (blood donors and other cancers). the results concern the sequence leeding fr ... | 1977 | 71006 |
| correlation of e antigen, dna polymerase activity, and dane particles in chronic benign and chronic active type b hepatitis infections. | the e determinant of hepatitis b surface antigen (hbs ag) was found in 23 of 42 patients with chronic hepatitis b virus (hbv) infection. presence of e antigen was associated with increases in dna polymerase activity and in the number of circulating dane particles. in the group with detectable e antigen, the average dna polymerase activity was 367+/-78 counts per minute (cpm; mean+/-standard error [se]), and the average number of dane particles counted in electron micrographs was 4.4% of the tota ... | 1977 | 68088 |
| hepatitis b "e" antigen: an apparent association with lactate dehydrogenase isozyme-5. | serums containing the "e" antigen of hepatitis b virus were subjected to electrophoresis in polyacrylamide gel. an extra band appeared in the lactate dehydrogenase isozyme pattern, but this band was undetectable in serums containing antibodies to the e antigenic determinant. prior separation of the lactate dehydrogenase isozyme-5 fraction by chromatography of serum on minicolumns of diethylaminoethyl-sephadex-a50 improved electrophoretic identification of the extra band. neutralization with anti ... | 1977 | 73221 |
| structure of hepatitis b dane particle dna and nature of the endogenous dna polymerase reaction. | the circular dna of hepatitis b dane particles, which serves as the primer/template for an endogenous dna polymerase, was analyzed by electrophoresis before and after a polymerase reaction and after digestion by restriction endonuclease or single-strand-specific endonuclease s1. the unreacted molecules extracted from the particles were electrophoretically heterogeneous, and treatment with s1 nuclease produced double-stranded linear dna ranging in length from 1,700 to 2,800 base pairs (bp). after ... | 1977 | 69727 |
| early lesions and development of primary hepatocellular carcinoma in man--association with hepatitis b viral infection. | it is well known that primary hepatocellular carcinoma could be derived from chronic hepatitis and liver cirrhosis in epidemiologic studies. however, it is still not clear what kinds of hepatocyte are premalignant cells. recently we have focused on liver cell dysplasia as a possible premalignant cell, and showed localization of alpha-fetoprotein in the cytoplasma of these cells. although the dysplastic cells were often seen in the liver of chronic active hepatitis, hepatitis b virus associated d ... | 1977 | 70387 |
| hepatitis-b virus in bedbugs (cimex hemipterus) from senegal. | bedbugs of the species cimex hemipterus (f) were collected on four separate occasions from the bedding in the huts of village dwellers in senegal, west africa. hepatitis-b surface antigen (hbsag) was detected in unengorged nymph and adult bedbugs in each of the first three collections. 3 of 28 such specimens were hbsag(+) in the first collection and 3 of 17 specimens were positive in the second collection. in the third, 6 of 9 were hbsag(+) when the bed occupant was known to be hbsag(+). 2 of th ... | 1977 | 69829 |
| association of human hepatocellular carcinoma and cirrhosis with hepatitis b virus surface and core antigens in the liver. | 1977 | 72736 | |
| continuous lymphoblastoid suspension cultures from cells of haematopoietic organs of baboons with malignant lymphoma. report iii: immunological studies. | lymphoblastoid cultures established from haematopoietic organs of baboons with lymphoma belong to the b-cell type. cytoplasmic antigen is revealed in 2--6% of suspension culture cells established from lymphomatous baboons by indirect immunofluorescence reaction using serum from human burkitt's lymphoma patients with antibody titer to capsid antigen of epstein-barr virus 1: 320. there is a correlation between the number of antigen-containing cells in these cultures and the number of cells in whic ... | 1977 | 71245 |
| coincident hepatitis b surface antigen and antibodies of different subtypes in human serum. | three patients with simultaneously detectable hepatitis b surface antigen (hbsag) and antibody (anti-hbs) in their sera were studied for subtypes of hbsag and anti-hbs. in each case anti-hbs was found to be directed to a different subtype than that of the circulating hbsag, indicating that reinfection (or simultaneous infection) with a second subtype occurred. | 1977 | 63520 |
| non-a, non-b post-transfusion hepatitis. | to clarify the role of hepatitis-a virus (h.a.v.) in the aetiology of post-transfusion hepatitis unrelated to hepatitis-b virus, we have tested and titred pre-transfusion and convalescent serum samples from 32 patients for antibody to hepatitis-a antigen (anti-ha) by quantitative immune adherence haemagglutination. 12 patients had no detectable anti-ha in either pre-transfusion or late convalescent serum; the other 20 had anti-ha in pretransfusion serum and no significant chance in titre during ... | 1977 | 65657 |
| reactivation of hepatitis-b virus. | 1977 | 65666 | |
| terminology of hepatitis viruses and antigens. recommendations of the who expert committee on viral hepatitis. | 1977 | 67103 | |
| prevalence of hepatitis b infection among residents of an institution for the mentally retarded. | data on prevalence of antibody to hepatitis b surface antigen (anti-hbs) and of hepatitis b surface antigen (hbsag) among 95 matched pairs of down's syndrome (ds) and other mentally retarded (omr) patients in an institution were analyzed by age on admission and by length of residence. passive hemagglutination test were used to determine anti-hbs. anti-hbs prevalence increased with admission age among ds patients (26%, 42% and 56% for age groups less than or equal to 5, 6-15 and greater than 15 y ... | 1977 | 138362 |
| immunodeficiency in down's syndrome: relationship between presence of human thyroglobulin antibodies and hbsag carrier status. | the relationship between the presence of hepatitis b surface antigen (hbsag) and antibodies to human thyroglobulin (htgab) has been studied in 110 subjects with down's syndrome (ds) from 4 months to 50 years of age and in 122 controls carefully matched for sex, age and socio-environmental conditions. the overall percentage of hbsag carriers was 22.7 in ds and 6.6 in controls and that of htgab-positive subjects was 41.8 in ds and 19.7 in controls. in ds the frequency of htgab-positive subjects wa ... | 1977 | 144056 |
| mixed cryoglobulinemia-an immune complex disease often associated with hepatitis b virus infection. | 1977 | 148133 | |
| hepatocellular carcinoma and chronic persistent hepatitis. | the morphologic type of cirrhosis that is followed most frequently by hepatocellular carcinoma is posthepatitic cirrhosis. furthermore, hb ag is detected in a high rate among cases with hepatocellular carcinoma suggesting the intimate causal relationship between hepatitis b virus and hepatocellular carcinoma. it has been considered that hepatocellular carcinoma might develop during destruction and regeneration of fully developed liver cirrhosis. however, hepatocellular carcinoma is combined with ... | 1977 | 200057 |
| parenterally transmitted non-a, non-b hepatitis: an epidemic reassessed. | in 1972 a nonsocomial outbreak of parenterally transmitted hepatitis affected both marrow transplant patients and normal platelet donors in an oncology unit. because of the characteristics of the clinical illness, the incubation period of 27 days, and the effect of immune serum globulin on the clinical illness, the outbreak was attributed to hepatitis a; there was no serologic evidence of either hepatitis b virus or cytomegalovirus infection. stored serums from this outbreak were re-examined by ... | 1977 | 195506 |
| recent advances in the identification of hepatitis viruses. | resulting directly from the discovery of virus-related antigens, rapid progress has marked the last decade of viral hepatitis research. the hepatitis b virion has been tentatively identified as a dna virus with an endogenous dna polymerase, and new serological markers for type b hepatitis have been discovered. hepatitis a antigen has been identified on a virus-like particle thought to be the hepatitis a virion. progressively more sophisticated assays for hepatitis antigens and antibodies have be ... | 1977 | 196274 |
| geographical distribution of the subtype of hepatitis b surface antigen in chinese. | using the much more sensitive hemagglutination inhibition assay for subtyping of hepatitis b surface antigen (hbsag), we examined the determinants a, d, w and r in 192 from 228 hbsag positive adults who had been found after screening with reversed passive hemagglutination method. sixty-four subtypable cases were asymptomatic carriers and the remaining 128 were liver disease patients. among them there was no significant difference of the subtypes, invariably with adw as the main subtype. geograph ... | 1977 | 196971 |
| experimental carcinoma of liver in macaque monkeys exposed to diethylnitrosamine and hepatitis b virus. | the effects of treatments with diethylnitrosamine (dena) and hepatitis b virus (hbv) on macaque monkeys were investigated by virus serology and by light and electron microscopy. the experimental groups comprised 43 newborn or juvenile cynomolgus and rhesus monkeys of both sexes. hbv neither had a carcinogenic effect nor increased the oncogenic effect of dena. however, hbv given to juvenile primates before treatment with dena resulted in subsequent gross and microscopic alterations consistent wit ... | 1977 | 198564 |
| [core and coat of the hepatitis b-virus and cytoplasmic viruslike particles in chronic hepatitis. an electron microscopic study (author's transl)]. | in the second liver biopsy material of a seropositive patient receiving immunosuppressive therapy (corticosteroid + imuran) for chronic active hepatitis (cah), intranuclear, ring-shaped, 20--25 nm in diameter non-coated particles (core) of liver cells and intracisternal filaments, 23 nm in diameter (coat) of the soft er in the "ground-glass" hepatocytes were demonstrated by electron microscopy. core-particles in the cytoplasm were seen occasionally. dane-particles could not be visualized. cytopl ... | 1977 | 200036 |
| [hbs-antigen induced extrahepatic immune-complex disease (author's transl)]. | a 62-year old patient was hospitalized with fever, polyarthritis and exanthema. all bacteriological, virological and biochemical findings were normal. the immunological analysis showed initially the hbs-antigen in the serum. no irregular antibody was found. chemotherapy was failing, but application of corticosteroids was followed by a dramatic improvement. nine weeks after the onset of the disease the patient was healthy again. antibodies against hbs-antigen were found 3 months later. the data s ... | 1977 | 138790 |
| hepatitis b virus and antigen-antibody complex diseases. | 1977 | 141006 | |
| transmission of non-a, non-b hepatitis. | in studies conducted in the early 1950s, sera from six asymptomatic blood donors, implicated in the transmission of viral hepatitis, were inoculated into 10 to 20 volunteers each. five of these "implicated" donor sera transmitted clinically apparent hepatitis to the recipients. the stored serum samples from these studies have been reanalyzed using serologic markers for hepatitis b virus and hepatitis a virus infection. two of the donor sera were hepatitis b surface antigen (hbsag)-positive, and ... | 1977 | 195505 |
| mutliple hepatitis viruses in multiple attacks of acute viral hepatitis. | we evaluated the causes of 30 episodes of acute viral hepatitis in 13 patients who had multiple attacks. two (seven per cent) of 30 bouts were caused by hepatitis a virus, and 12 (40%) by hepatitis b virus. no patient, however, had more than one attack with the serologic characteristics of type a or type b disease. thus, there were 16 bouts (53 per cent) not attributable to either of the two recognized hepatitis viruses. none of these "non-a, non-b" episodes, evaluated for infectious mononucleos ... | 1977 | 186710 |
| antibody to hepatitis b core antigen in patients with hepatocellular carcinoma. | hepatitis b surface antigen (hbsag), anti-hbs, and anti-hb core (hbc) were measured in 124 patients with hepatocellular carcinoma (hcc) in comparison with 299 control subjects of comparable ages, and in 48 cases of chronic hepatitis and 52 cases of hepatic cirrhosis. it was found that 72.6% of the hcc patients were positive for anti-hbc, and 80.6% were positive for at least one test, whereas in the control, anti-hbc was positive in 30.1% and 34.1% were positive for at least one test, the differe ... | 1977 | 192626 |
| hepatitis b virus infection and primary hepatocellular carcinoma. | ninety-three patients with biopsy-proven primary hepatocellular carcinoma (phc) from uganda, zambia, and the united states were examined for serologic evidence of hepatitis b virus (hbv) infection. patients were tested for hepatitis b surface antigen (hbsag) and its antibody (anti-hbs), antibody to the hepatitis b core antigen (anti-hbc), hepatitis b e antigen (hbeag), and its antibody (anti-hbe). active hbv infection, as indicated by positive tests for hbsag (with or without anti-hbs) and anti- ... | 1977 | 192895 |
| acute viral hepatitis: modern knowledge. | 1977 | 193084 | |
| advances in viral hepatitis. report of the who expert committee on viral hepatitis. | 1977 | 193307 | |
| [etiology and epidemiology of viral hepatitis]. | 1977 | 211575 | |
| hepatitis ain greenland: importance of specific antibody testing in epidemiologic surveillance. | an epidemic of viral hepatitis type a in an arctic area is described. from 1970-1974, 4961 clinical cases of hepatitis were reported in greenland, corresponding to 11 per cent of the total population. epidemiologic surveillance indicated person-to-person transmission of the disease, apparently by the oralfecal route. the course of the disease was mild, and complications were rare with a case fatality rate of 0.3%. ninety-three per cent of the cases occurred in individuals 1-25 years of age, sugg ... | 1977 | 189600 |
| cellular localization of hepatitis b virus antigens in patients with hepatocellular carcinoma coexisting with liver cirrhosis. | specimens of liver tissue obtained by biopsy from five patients and at necropsy from seven patients with postnecrotic liver cirrhosis and hepatocellular carcinoma were examined for the presence of hepatitis b surface antigen (hbs ag) and hepatitis b core antigen (hbc ag) by direct immunofluorescence. in all cases, samples of serum were tested for hbs ag and antibody to hbs ag (anti-hbs) by immunoelectroosmophoresis and for antibody to hbc ag (anti-hbc) by indirect immunofluorescence. of these 12 ... | 1977 | 190331 |
| the relationship between hepatitis b virus infection and hepatic cell carcinoma in mozambique. | hepatitis b surface antigen and antibody were sought in sera collected from patients with hepatic cell carcinoma and from healthy blood donors. the frequency of the antigen among the patients was significantly higher than that among blood donors who served as controls (p = less than .01) but no significant difference was found in estimated exposure to hepatitis b virus between hepatic cell carcinoma patients and african blood donors. however, exposure to hepatitis b virus was significantly less ... | 1977 | 202048 |
| hepatoma and hepatitis b virus. | 1977 | 188786 | |
| anti-hbc titer in relation to the etiological role of hepatitis b virus in primary hepatocellular carcinoma. | the antibody to hepatitis b core antigen (anti-hbc) is belived to be a marker for natural infection with hepatitis b virus (hbv). in order to study the etiological role of hbv in relation to primary hepatocellular carcinoma (phc), the anti-hbc in sera of 31 phc patients was surveyed by the immune adherence hemagglutination method which was about 10 times more sensitive than the complement fixation method. twenty two out of 31 phc cases were positive for anti-hbc (71.0%). the is a higher rate of ... | 1977 | 192028 |
| failure to transmit human viral hepatitis types a and b to the congenitally athymic nude mouse. | 1977 | 202797 | |
| hepatocellular carcinoma and hepatitis b. | 1977 | 204083 | |
| partial amino acid sequence of two major component polypeptides of hepatitis b surface antigen. | determination of the amino acid sequence of the immunogenic polypeptides of hepatitis b surface antigen may not only permit molecular localization of the distinct determinants a, d, and y but may also lead to the synthesis of a hapten useful in prophylactic immunization against hepatitis b virus infection. for this purpose, purified monotypic hepatitis b surface antigen of adw subtype was resolved into equal amounts of two major polypeptides (22,000 and 28,000 daltons) and up to six other minor ... | 1977 | 266193 |
| association of e antigen with dane particle dna in sera from asymptomatic carriers of hepatitis b surface antigen. | sera containing hepatitis b surface antigen from 30 asymptomatic blood donors were assayed for e antigen (hbeag) and antibody to e antigen (anti-hbe) by rheophoresis,. fourteen samples (47%) had detectable hbeag, ten (33%) had anti-hbe, and six (20%) had neither. dna was extracted from 26 of these sera and assayed for its ability to anneal to a [32p]-dna probe that is a copy of dane particle dna. all 10 hbeag-positive samples tested contained dna that formed specific hybrids with the dna probe, ... | 1977 | 266736 |
| rebuttal to a jama editorial: hepatitis b--traffic in the dentist's office. | 1977 | 267655 | |
| [the dentist's responsibility in the oral rehabilitation of patients with chronic kidney diseases]. | it is important that the dentist knows about disturbances of blood coagulation during and after hemo-dialysis, so that he avoids administration of platelet-inhibiting medication like aspirin and that he recognizes radiologically visible signs of insufficient dialysis in the jaws. because of the reduced protection from infections, antibiotic prophylaxis should be carried out before every dental operation, the medication of choice being penicillin. due to the high rate of infection by the hepatiti ... | 1977 | 265241 |
| sex differences in response to hepatitis b infection among patients receiving chronic dialysis treatment. | patients undergoing treatment at a community-based renal dialysis clinic were monitored monthly for hepatitis b surface antigen (hbsag) and antibody to hbsag (anti-hbs). of 160 patients who began treatment hbsag(-)/anti-hbs(-), 77 subsequently became hbsag(+). once hbsag(+), males were more likely to remain hbsag(+) indefinitely, whereas females were more likely to convert to hbsag(-) and develop anti-hbs. this was not due to a sex difference in exposure to hepatitis b virus because only patient ... | 1977 | 267950 |
| immune response to hepatitis b virus in children with papular acrodermatitis. | papular acrodermatitis of childhood (pac) is characterized by papular eruption of skin, lymphadenopathy, and acute hepatitis b surface antigen (hbsag)-positive anicteric hepatitis. to study the course of hepatitis b virus infection we followed 16 patients with pac, 2 to 7 years of age, for periods ranging from 6 to 46 months. all patients tested developed hepatitis b surface antigenemia subtype ay, and produced antibody to hepatitis b core antigen with the highest incidence after 3 to 5 months. ... | 1977 | 332578 |
| immunological abnormalities associated with liver disease: cause or effect? | immunological abnormalities are demonstrable in patients with various types of liver damage. these may be (a) non-specific and unrelated to pathogenesis, e.g. auto-antibodies such as anti-nuclear factor; (b) specifically directed against liver antigens but not pathogenetic, e.g. cell mediated immune (cmi) reactions to liver antigen as seen in experimental carbon tetrachloride poisoning; (c) of such a nature as to modify the pathology produced by hepatotoxic agents, e.g. hepatitis b virus or alco ... | 1977 | 274938 |
| the genome of hepatitis b virus. | 1977 | 334041 | |
| host specificity of a serum marker for hepatitis b: evidence that "e antigen" has the properties of an immunoglobulin. | a family of antigens, referred to collectively as e antigen (eag), has been detected in sera of some individuals with liver disease who test positive for hepatitis b surface antigen. studies on eag partially purified by affinity chromatography on insolubilized antibodies to eag revealed the following: (i) eag has the physicochemical and immunologic properties of an immunoglobulin, predominantly of the igg4 subclass, and (ii) specific antigenic sites, designated as e determinants, differentiate e ... | 1977 | 266209 |
| association of graft survival with host response to hepatitis b infection in patients with kidney transplants. | we studied the relation of host response to hepatitis b infection before transplantation with survival of kidney grafts in 79 patients receiving 87 transplants. antibody to hepatitis b surface antigen (anti-hbs) signaled early graft rejection (median survival congruent to two months), whereas hepatitis b surface antigen (hbsag) signaled delayed rejection (greater than 22 months). patients with neither hbsag nor anti-hbs had graft survival times (median congruent to 16 months) similar to the hbsa ... | 1977 | 318732 |
| humoral and cell-mediated immunity to hepatitis b virus antigen in a haemodialysis-renal transplantation unit. | hepatitis b surface antigen (hbsag), the corresponding antibody (anti-hbs), the antibody to hepatitis b core antigen (anti-hbc), and the cellular immune response to purified hbsag (leucocyte migration inhibition test: lmt-hbsag) were determined in 19 staff members, 11 long-term haemodialysis patients, and 22 renal transplant patients in a haemodialysis-renal transplantation unit. past or present infection, as expressed by the presence of circulating anti-hbs or hbsag, was found in 30 cases (58 p ... | 1977 | 343497 |
| vertical transmission of hepatitis-b surface antigen. | transmission of hepatitis b virus from mother to infant can cause a severe type of neonatal hepatitis. comparing chronic carrier mothers with mothers who have acute hepatitis in pregnancy we find that the latter group present the greater risk to their infants. differences in the presence of hepatitis b core and hepatitis b e antigen and antibody in the acute case and in the carrier state may expoain the differences observed in the transmission rates of two groups. in countries where the prevalen ... | 1977 | 324529 |
| acute and chronic hepatitis: multisystemic involvement related to immunologic disease. | 1977 | 320847 | |
| [epidemiological study of hepatitis b virus in children in the aki area, kochi-ken, japan]. | 1977 | 321837 | |
| antibodies to hepatitis b core antigen in hepatitis b surface antigen-positive and -negative chronic hepatitis. | antibody to hepatitis b core antigen (anti-hbc) is a sensitive indicator of hepatitis b virus (hbv) infection. however, anti-hbc has been found in only a few patients with chronic hepatitis. therefore, we tested for anti-hbc in 124 sera from 67 patients with histologically proven chronic hepatitis by the indirect fluorescent antibody technique. all patients, except for one with chronic hepatitis who was seropositive for hepatitis b surface antigen (hbs ag), had anti-hbc that persisted throughout ... | 1977 | 325149 |
| [significance of the antigen and the anti-e antibody in patients with surface antigen of hepatitis b virus]. | 1977 | 302013 | |
| t and b lymphocytes in uremic patients with type b hepatitis infection. | peripheral t and b lymphocytes were measured in (1) hepatitis b surface antigen (hbsag)-positive, (2) hbsag-negative uremic patients on chronic hemodialysis (chd) therapy, and (3) patients with type b chronic active viral hepatitis (cavh). when compared to normals, a decrease in the absolute number of t and b lymphocytes was detected in both chd groups. cavh patients had a decrease in the total number of t lymphocytes. when expressed as percentage of t lymphocytes, normals and hbsag-negative chd ... | 1977 | 300854 |
| t-lymphocyte cytotoxicity to hbsag-coated target cells in hepatitis b virus infection. | the cytotoxic effect of peripheral lymphocytes on chicken red blood cells (chrbc) coated with purified hepatitis b surface antigen (hbsag) has been studied as an in vitro parameter of cell-mediated immunity in acute and chronic infection with hepatitis b virus. using this technique, the mean cytotoxic index of lymphocytes from patients with acute hepatitis b (29.13 +/- 20.88) was significantly higher than that obtained with lymphocytes from control subjects (6.53 +/- 3.75). only 33.3% of the pat ... | 1977 | 304824 |
| hepatitis b prevalence within a dental student population. | in this descriptive epidemiologic study, prevalence rates of hepatitis b surface antigen (hbsag) and its antibody (anti-hbs) among fourth-year dental students and second-year dental hygiene students were found to be comparable to those of a control population and a local age-adjusted blood donor group. this observation contrasts with the rates reported for practicing dentists, especially oral surgeons, and indicates that the increased risk experienced by dentists after dental school may be attri ... | 1977 | 264921 |
| viral hepatitis: enzyme assays and serologic procedures in the study of an epidemic. | an epidemic of viral hepatitis beginning in late 1975 in a residence for multiply handicapped children, recognized very early in its course, was investigated prospectively to permit comparison of enzymatic and serologic tests. thirty-three residents of the institution and 46 full- and part-time employees were studied by the immune adherence hemagglutination procedure for antibody (anti-hav) to hepatitis a virus (hav). of these, 31 residents and 37 staff members were susceptible at the beginning ... | 1977 | 201170 |
| prevalence of antibody to hepatitits b surface antigen among staff in an edinburgh hospital. | antibody to hepatitis b surface antigen was detected by radioimmunoprecipitation in 74 (5-5%) of 1336 staff members in a large general hospital in edinburgh, in 14 (2-9%) of 480 volunteer blood donors in the area, and in 12 (6-1%) of 197 pregnant women attending for the first time at the ante-natal clinic in the hospital. rates of antibody prevalence rose with age in the sample of hospital staff and in that of the blood donors, particularly among males. on the other hand, in the ante-natal patie ... | 1977 | 264499 |
| hepatitis, an occupational hazard. | 1977 | 217861 | |
| [transmission of hepatitis b virus from the mother to the infant]. | 1977 | 243551 | |
| australia antigen and the biology of hepatitis b. | 1977 | 325649 | |
| identification of lymphocytes in percutaneous liver biopsy cores. different t:b cell ratio in hb sag-positive and -negative hepatitis. | the lymphocytes infiltrating the liver were isolated and characterized as t or b cells in three groups of patients: 20 patients with hepatitis b surface antigen (hb sag)-positive acute and chronic hepatitis, 8 patients with hbsag-negative chronic hepatitis with prior evidence for hepatitis b virus (hbv) infection, and 5 patients with hbsag-negative chronic hepatitis without prior evidence for hbv infection. the predominant cell infiltrating the liver was shown to be a t cell in all categories; h ... | 1977 | 323096 |
| [medical nobel prize in 1976]. | 1977 | 323771 | |
| [comparative study of three technics of inverse passive hemagglutination in the search for a surface antigen of the hepatitis b virus (ag hbs) (author's transl)]. | the following three different versions of reverse passive hemagglutination (rpha) were evaluated for the detection of hbs antigen: auscell i - abbott, wh hbs - wellcome and the hepanosticon - organon technique and results obtained were compared with those obtained by the radio immuno assay (ausria ii of abbott). in 493 sera studied, up to 16,8% were found positive by rpha as compared to 17,2% positives by ria. the percentage of false positives by the different methods varied from 4,9 to 7,3. con ... | 1977 | 327414 |
| [magnius' e-antigen]. | the "e" ag/ac system found by magnius in 1972 is discussed briefly. the new antigen has the same immologic and physiochemical characteristics of hbs and hbc of the hepatitis virus. its existence shows the chronic evolution of the disease in ag hbs carriers. therefore the "e" antigen has a prognostic value in ag hbs carries. | 1977 | 329074 |
| correlation between titer of antibody to hepatitis b core antigen and presence of viral antigens in the liver. | liver specimens of 31 autopsied cases of liver cirrhosis who had had detectable levels of antibody to hepatitis b core antigen (anti-hbc) inthe serum were stained for hepatitis b core antigen (hbcag) and hepatitis b surface antigen (hbsag) by the direct immunofluorescence method. their premortem serum samples were tested for hbsag, antibody to hbsag (anti-hbs) and anti-hbc. persistent hepatitis b virus (hbv) infection as judged by circulating and/or liver hb antigens was identified in 18 patien ... | 1977 | 330306 |
| eukaryotic dna polymerases. | 1977 | 332062 | |
| simultaneous presence of hbsag and anti-hbs in the serum of different subtypes (serological and immunofluorescent studies). | serological and immunofluorescent studies were performed in 3 patients with the simultaneous presence of hbsag and anti-hbs in the serum. our investigations revealed the following results: hbsag and anti-hbs in the serum were of different subtypes. hbsag in the serum and in the liver had the same subtype. hbsag in the liver did not react with the circulating anti-hbs in the patient's own serum. hbsag-anti-hbs immune complexes could not be detected in the serum or in the liver tissue. these pheno ... | 1977 | 333803 |
| fluorescent antibody study of diseased, end-stage human kidneys. | forty cases of diseased kidneys at end-stage were studied by fluorescent antibody technique in search for viral etiology of glomerulonephritis and other renal diseases. among these 40 cases, 12 (30%) were ascribed to immune complex disease because of detection of immunoglobulins and complement in glomeruli of the same kidney specimen. in 8 cases (20%) only complement was detected in glomeruli. in the remaining 50% neither complement nor immunoglobulin deposit was found in glomeruli. the etiologi ... | 1977 | 357100 |
| hepatitis b in ward and clinical laboratory employees of a general hospital. | after a sharp increase in viral hepatitis cases, mostly type b, among the 2000 employees of a general hospital during three years, we conducted an investigation which consisted of obtaining data on employee cases and surveying many current employees. of the 38 cases, 22 occurred in non-physician, ward employees. of 189 current ward employees, 8% had antibody to hepatitis b surface antigen (anti-hbs) and 1% had hepatitis b surface antigen (hbsag). hepatitis b virus (hbv) seropositivity was highes ... | 1977 | 333905 |
| enzyme immunoassay for hepatitis b and its comparison to other methods. | a solid-phase enzyme immunoassay for the qualitative detection of hepatitis b surface antigenemia is presented and the results compared to the counter-immunoelectrophoresis and radioimmunoassay methods for detection of the same antigen. the enzyme-antibody conjugate was prepared from horseradish peroxidase coupled with antibodies to three sub-types of hepatitis b virus. polystyrene plastic tubes were used as the solid-phase support. the results of the enzyme immunoassay compare favorably with ra ... | 1977 | 336244 |
| [comparison between the presence of specific circulating immune complexes and the leukocyte migration inhibition test in different clinical forms of hepatitis b]. | circulating immune complexes were measured by a radioimmunoassay specific for hb complexes in different clinical situations related to hepatitis b virus infection. the leukocyte migration inhibition test (lmit) was performed simultaneously. comparison with the clinical situation suggests that immune complexes are not responsible for the lesions, but that these lesions might be produced by the immunity demonstrated by the lmit. a deficiency of this immunity is responsible for the persistence of i ... | 1977 | 337469 |
| the outcome of hepatitis b virus infection in pregnancy. | the literature concerning hepatitis b in pregnancy is reviewed and problems of management of both the acute and chronic infections are discussed. | 1977 | 339213 |
| [maternal transmission of the hepatitis b virus (incidence and results)]. | 1977 | 342329 | |
| localisation of e-antigen in nuclei of hepatocytes in hbsag-positive liver diseases. | by the direct immunofluorescence technique 19 liver biopsies were examined for the presence of the e-antigen associated with the hepatitis b virus infection. with the use of double incubation and blocking experiments with fitc and rhodamine labelled antisera against hepatitis b core antigen and e-antigen, evidence is presented that the e-antigen is localised in the nuclei of the hepatocytes. we conclude that the e-antigen and the core antigen are not identical, although they are often present si ... | 1977 | 342357 |
| anti-hb immunoglobulin and its use in the prevention of hepatitis b. | 1977 | 410078 | |
| [vaccination against hepatitis b in man]. | the preparation of a vaccine against hepatitis b is described. the vaccine is prepared from the hb viral coat (hbs ag) purified and formalin inactivated. the hbs ag is isolated and purified from the blood of healthy hbs ag positive donors by means of an immunoadsorbent technique. the inocuity and efficacy were tested on chimpanzees. vaccination was then applied in an attempt to protect patients and ward staff in a high risk haemodialysis unit. the efficacy of the vaccine was assessed by humoral ... | 1977 | 401985 |
| discordant e antigen, dna polymerase activity, and dane particle responses in two patients representing an index case-contact case pair with hepatitis b virus infection. | discordant results for e antigen, dna polymerase activity, and dane particle frequency were noted in the sera of two patients representing an index case-contact case pair with chronic aggressive hepatitis b. the lack of correlation between presence of e antigen and the infecting viral strain, as well as the strong relationship of e antigen to persistent and significant viremia, emphasize the role of the host's immune response in the expression of this antigen. | 1977 | 407311 |
| [significance of eag in hbsag positive families]. | 1977 | 407315 | |
| [use of a highly-sensitive method of electrophoresis-precipitation for detecting hepatitis b virus antigen in human serum]. | a modification of the highly-sensitive method of electrophoresis-precipitation in polyacrylamide gel used for detection of the virus hepatitis b antigen (hbsag) and the anti-hbsag is described. the method completely retains the specificity of the gel immunodiffusion test, but is 100--2000 times more sensitive in hbsag detection. the sera of patients with different pathology were checked by this method. in comparison with the methods used before the hbsag determination by the mentioned method pro ... | 1977 | 403983 |
| hepatitis b virus infection on taiwan. | 1977 | 757978 | |
| prognostic implications of the e antigen of hepatitis b virus. | the e antigen hbeag and its antibody anti-hb, have been said to be predictive of chronicity and resolution, respectively, in viral hepatitis. we found, as have others, a specific association with hepatitis b virus-induced disease. in addition, detectability of hbeag in the acute phase of type b hepatitis was followed by a sixfold higher incidence of chronic hepatitis. unfortunately, the prediction was erroneous in 65% of positive cases and 6% of negative cases. in chronic hepatitis, hbeag did no ... | 1977 | 578882 |
| [hbv (hepatitis b virus) infection through the birth canal]. | 1977 | 587187 | |
| high prevalence of hepatitis b virus infection among heavy alcohol drinkers in japan. | 1977 | 611365 | |
| australia antigen--a fresh approach. | 1977 | 614407 | |
| hepatitis-b surface antigen and antibody in black and white patients with venereal diseases. | the prevalence of both the hepatitis-b surface antigen (hbsag) and its specific antibody (anti-hbs) was significantly greater in the sera of white patients suffering from sexually transmitted diseases than that in white blood donors. however, black patients with venereal diseases did not show an increased prevalence of either hbsag or anti-hbs. these findings support the view that heterosexual transmission of the hepatitis-b virus is less likely to occur in populations in whom this infection is ... | 1977 | 580069 |
| [epidemiologic study of chronic hepatitis in relation to heptatis b virus infections (author's transl)]. | in order to evaluate the role of hepatitis b virus (hbv) in the etiology of chronic liver diseases, paired sera of 143 patients with biopsy-documented chronic hepatitis were tested for hbsag and anti-hbs by radioimmunoassay method. hbsag was detected in 67.3% of patients with a preceding verified eipsode of acute hepatitis, and in 26.7% of patients with a cryptogenic form of chronic hepatitis. hbsag was not found in any of patients with alcoholic chronic hepatitis and in only two of 18 patients ... | 1977 | 616263 |
| [hepatitis b antigen (hbsag) in hospitalized children]. | blood samples of 1940 hospitalized children aged 0--18 years were investigated for presence of hbs-ag by counter-electrophoresis, haemagglutination and radioimmunoassay, hbs-ag was found in 1.34% of all patients, being distributed evenly amongst boys and girls. the incidence was 1.7% in patients from a large university children's hospital and 0.6% in patients from a group of regional hospitals. of 26 samples positive by radioimmunoassay, 1 only was found positive by insensitive counter-electroph ... | 1977 | 617959 |
| disparate response of monozygotic twins to hepatitis b virus infection. | 1977 | 559734 | |
| serodiagnosis of hepatitis b virus infection by antibody to core antigen. | in a military population antibody to hepatitis b core antigen (anti-hbc) was found in 39% of acute hepatitis cases negative for hepatitis b surface antigen (hbs ag) and in 96% of hbs ag-positive cases. persistence of antibody to hbs ag (anti-hbs) in convalescent-phase sera was significantly greater (p less than 0.001) in individuals with acute hbs ag-positive hepatitis b than in patients with clinical hbs ag-negative hepatitis b. the prevalence of anti-hbc in the absence of hbs ag, anti-hbs, and ... | 1977 | 560416 |