Publications

immunogenicity and safety of hepatitis b vaccination in patients with type 2 diabetes in china: an open-label randomized controlled trial.	hepatitis b virus (hbv) infection remains a global public health challenge. patients with diabetes are at greater risk of hbv infection than healthy people. the immunogenicity and safety of two major hepatitis b vaccines were evaluated in chinese patients with diabetes.	2021	33992438
diversification of mammalian deltaviruses by host shifting.	hepatitis delta virus (hdv) is an unusual rna agent that replicates using host machinery but exploits hepatitis b virus (hbv) to mobilize its spread within and between hosts. in doing so, hdv enhances the virulence of hbv. how this seemingly improbable hyperparasitic lifestyle emerged is unknown, but it underpins the likelihood that hdv and related deltaviruses may alter other host-virus interactions. here, we show that deltaviruses diversify by transmitting between mammalian species. among 96,6 ...	2021	33397804
a longitudinal observational study in two cats naturally-infected with hepadnavirus.	hepatitis b virus (hbv) is a major cause of liver disease in humans including chronic hepatitis and hepatocellular carcinoma. domestic cat hepadnavirus (dch), a novel hbv-like hepadnavirus, was identified in domestic cats in 2018. from 6.5 %-10.8 % of pet cats are viremic for dch and altered serological markers suggestive of liver damage have been identified in 50 % of dch-infected cats. dch dna has been detected in association with characteristic lesions of chronic hepatitis and with hepatocell ...	2021	33524809
molecular detection and characterisation of domestic cat hepadnavirus (dch) from blood and liver tissues of cats in malaysia.	a new domestic cat hepadnavirus (dch, family hepadnaviridae) was first reported from whole blood samples of domestic cats in australia in 2018, and from cat serum samples in italy in 2019. the pathogenesis of dch is unknown, but it was reported in cats with viraemia (6.5-10.8%), chronic hepatitis (43%) and hepatocellular carcinoma (28%). recent reports suggest that dch resembles the human hepatitis b virus (hbv) and its related hepatopathies. this study aims to detect and characterize dch among ...	2021	33407487
studies on the efficacy, potential cardiotoxicity and monkey pharmacokinetics of glp-26 as a potent hepatitis b virus capsid assembly modulator.	while treatment options are available for hepatitis b virus (hbv), there is currently no cure. anti-hbv nucleoside analogs and interferon-alpha 2b rarely clear hbv covalently closed circular dna (cccdna), requiring lifelong treatment. recently, we identified glp-26, a glyoxamide derivative which modulates hbv capsid assembly. the impact of glp-26 on viral replication and integrated dna was assessed in an hbv nude mouse model bearing hbv transfected ad38 xenografts. at day 45 post-infection, glp- ...	2021	33467678
analysis of codon usage of horseshoe bat hepatitis b virus and its host.	in the present analysis, codon usage strategies and base distribution of horseshoe bat hepatitis b virus (hbhbv) were analyzed and compared with its host rhinolophus sinicus, as no work was yet reported. the magnitude of synonymous codon usage bias (cub) in the virus and its host was low with higher proportion of the base c. notably, 21 more frequently used codons, 19 less frequently used codons and 3 underrepresented codons (tcg, acg and gcg) were found to be similar in both virus and its host ...	2021	34171764
a systematic study of tupaia as a model for human acute hepatitis b infection.	the molecular features of hepatitis b virus (hbv) infection, eradication, and pathogenesis are poorly understood, partly due to the lack of an adequate animal model that faithfully reproduces the course of infection. although tupaia belangeri were previously recognized as hbv-susceptible animals, the course of infection in adult tupaias remains obscure. herein, we performed a longitudinal study and demonstrated that adult tupaias were efficiently infected (90% infection rate) with 108 copies of ...	2021	33952781