Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| diabetes, epstein-barr virus and extranodal natural killer/t-cell lymphoma in india: unravelling the plausible nexus. | the international diabetes federation diabetes atlas estimates a staggering 590 million people affected with diabetes mellitus (dm) within the next two decades globally, of which type 2 dm will constitute more than 90%. the associated insulin resistance, hyperinsulinemia, and hyperglycemia pose a further significant risk for developing diverse malignant neoplasms. diabetes and malignancy are multifactorial heterogeneous diseases. the immune dysfunction secondary to type 2 diabetes also reactivat ... | 0 | 27051150 |
| expression of epstein-barr virus antibodies ea-igg, rta-igg, and vca-iga in nasopharyngeal carcinoma and their use in a combined diagnostic assay. | epstein-barr virus (ebv) infection is closely associated with nasopharyngeal carcinoma, which can be monitored by the levels of rta protein antibody igg (rta-igg), early antigen antibody (ea-igg), and viral capsid antibody (vca-iga). in the present study, we investigated the serum levels of rta-igg, ea-igg, and vca-iga in nasopharyngeal cancer patients, and the diagnostic value of a combined assay that includes these antibodies in addition to the ebv-dna. a total of 56 nasopharyngeal cancer pati ... | 2016 | 27050964 |
| downregulation of atoh8 induced by ebv-encoded lmp1 contributes to the malignant phenotype of nasopharyngeal carcinoma. | mechanism for the malignant phenotype of nasopharyngeal carcinoma (npc) remains poorly understood. epstein-barr virus (ebv) consistently appears in nearly all malignant npc patient samples, suggesting the strong etiological link between the malignant phenotype and ebv infection. here we found that the ebv-encoded latent membrane protein (lmp1) enhanced cell growth, motility, invasion and xenograft tumor growth of npc. rna-seq profiling analysis of lmp1-positive npc patient tissues indicated that ... | 2016 | 27049918 |
| mechanism of action of ebv, bcl-2, p53, c-myc and rb in non-hodgkin's lymphoma. | the aim of the present study is to explore the mechanism of action of several proteins, including epstein-barr virus (ebv), b-cell lymphoma (bcl)-2, p53, c-myc and retinoblastoma (rb), in non-hodgkin's lymphoma (nhl). | 2016 | 27049262 |
| a novel antibody discovery platform identifies anti-influenza a broadly neutralizing antibodies from human memory b cells. | monoclonal antibody isolation directly from circulating human b cells is a powerful tool to delineate humoral responses to pathological conditions and discover antibody therapeutics. we have developed a platform aimed at improving the efficiencies of b cell selection and v gene recovery. here, memory b cells are activated and amplified using epstein-barr virus infection, co-cultured with cho-mucd40l cells, and then assessed by functional screenings. an in vitro transcription and translation (ivt ... | 2016 | 27049174 |
| computational analysis of ebna1 "druggability" suggests novel insights for epstein-barr virus inhibitor design. | the epstein-barr nuclear antigen 1 (ebna1) is a critical protein encoded by the epstein-barr virus (ebv). during latent infection, ebna1 is essential for dna replication and transcription initiation of viral and cellular genes and is necessary to immortalize primary b-lymphocytes. nonetheless, the concept of ebna1 as drug target is novel. two ebna1 crystal structures are publicly available and the first small-molecule ebna1 inhibitors were recently discovered. however, no systematic studies have ... | 2016 | 27048620 |
| epstein-barr virus and its association with oral hairy leukoplakia: a short review. | in immunocompromised subjects, epstein-barr virus (ebv) infection of terminally differentiated oral keratinocytes may result in subclinical productive infection of the virus in the stratum spinosum and in the stratum granulosum with shedding of infectious virions into the oral fluid in the desquamating cells. in a minority of cases this productive infection with dysregulation of the cell cycle of terminally differentiated epithelial cells may manifest as oral hairy leukoplakia. this is a white, ... | 2016 | 27047546 |
| factors associated with onset, relapses or progression in multiple sclerosis: a systematic review. | multiple sclerosis (ms) is a chronic disease of the central nervous system with an unidentified etiology. we systematically reviewed the literature on the possible risk factors associated with ms disease onset, relapses and progression from 1960 to 2012 by accessing six databases and including relevant systematic reviews, meta-analyses, case-control or cohort studies. the focus was on identifying modifiable risk factors. fifteen systematic reviews and 169 original articles were quality assessed ... | 2016 | 27045883 |
| evaluation of ebv transformation of human memory b-cells isolated by facs and macs techniques. | several studies have been performed to develop effective neutralizing monoclonal antibodies. the epstein-barr virus (ebv) can efficiently immortalize b-cells to establish lymphoblastoid cell lines (lcl) and so it has been used extensively for transformation of b-cells to produce and secrete immunoglobulin. the present study addressed the effect of tlr7/8 agonist (r848), feeder cells layer and fluorescence-activated cell sorting (facs) and magnetic-activated cell sorting (macs) cell separation met ... | 2016 | 27043044 |
| severe hypersplenism associated to hemophagocytic and lymphoproliferative syndrome secondary to epstein-barr virus infection. a report of two cases. | 2016 | 27041246 | |
| epstein-barr virus reactivation is induced, but abortive, in cutaneous lesions of systemic hydroa vacciniforme and hypersensitivity to mosquito bites. | epstein-barr virus (ebv)-associated t/natural killer (nk)-lymphoproliferative disorders (lpds) include hydroa vacciniforme (hv) and hypersensitivity to mosquito bites (hmb). the pathomechanisms of these diseases are still unclear. | 2016 | 27039668 |
| performance of an antigen assay for diagnosing acute hepatitis e virus genotype 3 infection. | hepatitis e virus (hev) is a major cause of hepatitis worldwide. its diagnosis is based on the detection of anti-hev igm and/or hev-rna. | 2016 | 27038538 |
| acute cholestatic hepatitis induced by epstein-barr virus infection in an adult: a case report. | acute cholestatic hepatitis without features of infectious mononucleosis is a rare presentation of primary epstein-barr infection, with only several cases previously reported in the medical literature. early investigation for epstein-barr virus in febrile patients with deranged liver function tests and no demonstrable biliary obstruction on imaging can expedite both diagnosis and treatment, thereby avoiding costly or invasive procedures such as liver biopsy. | 2016 | 27037083 |
| immunological methods for the detection of porcine lymphotropic herpesviruses (plhv). | porcine lymphotropic herpesviruses (plhv-1, -2, and -3) are widespread in pigs and closely related to the human pathogenic gammaherpesviruses epstein-barr virus (human herpesvirus 4, hhv-4) and kaposi sarcoma herpesvirus (hhv-8). in minipigs, plhv-1 causes a porcine post-transplantation lymphoproliferative disorder (ptld) after experimental transplantations. porcine ptld comes with clinical symptoms similar to those of human ptld, a serious complication of solid organ and allogeneic bone marrow ... | 2016 | 27036503 |
| environmental factors and their interactions with risk genotypes in ms susceptibility. | the area of multiple sclerosis (ms) epidemiology has expanded during the last few years. established lifestyle and environmental factors influencing ms risk are epstein-barr virus infection, sun exposure/vitamin d, and smoking. we review these factors and a series of other potential candidates implicated in the pathogenesis of ms and how environmental factors interact with genetic susceptibility with regard to disease risk. | 2016 | 27035899 |
| plasmablastic lymphoma mimicking acute pancreatitis. | background. plasmablastic lymphoma (pbl) is a rare b-cell neoplasm. it predominantly occurs in the oral cavity of human immunodeficiency virus (hiv)-positive patients and exhibits a highly aggressive clinical behavior. case presentation. we describe an unusual case of a 37-year-old hiv-positive male who presented with acute pancreatitis secondary to multiple peripancreatic masses compressing the pancreas. histopathological examination of the lesions showed diffuse and cohesive pattern of large b ... | 2016 | 27034868 |
| murine models of epstein-barr virus-associated lymphomagenesis. | the epstein-barr virus (ebv) is a b-lymphotropic gamma herpes virus associated with a number of malignancies. most ebv-related cancers present complex medical management challenges; thus it has been essential to develop preclinical in vivo models allowing for the study of pathogenesis, prevention, and treatment of these diseases. early in vivo models used nonhuman primates; however, such models were limited by the inability of ebv to achieve viral latency, availability, and cost. immunodeficient ... | 2016 | 27034395 |
| detection of active epstein-barr virus infection in duodenal mucosa of patients with refractory celiac disease. | refractory celiac disease is characterized by mucosal damage in patients with celiac disease despite a gluten-free diet. little is known about the mechanisms that cause persistent intestinal inflammation in these patients. we performed a case-control study of 17 consecutive patients diagnosed with refractory celiac disease from 2001 through 2014 (median age, 51 y; 10 women) and 24 patients with uncomplicated celiac disease (controls) to determine whether refractory disease is associated with inf ... | 2016 | 27033429 |
| a protein and mrna expression-based classification of gastric cancer. | the overall survival of gastric carcinoma patients remains poor despite improved control over known risk factors and surveillance. this highlights the need for new classifications, driven towards identification of potential therapeutic targets. using sophisticated molecular technologies and analysis, three groups recently provided genetic and epigenetic molecular classifications of gastric cancer (the cancer genome atlas, 'singapore-duke' study, and asian cancer research group). suggested by the ... | 2016 | 27032689 |
| killer-specific secretory (ksp37) gene expression in subjects with down's syndrome. | down syndrome is characterized by dysmorphic features, mental retardation and problems of immune deficiency. chronic infection by epstein-barr virus is frequently present in subjects with down syndrome. ksp37 gene is commonly expressed by nk, cd8(+) t, γδ t and cd4(+) t cells; these data suggest that ksp37 have cytotoxic properties. an increase of ksp37 protein serum levels it has been showed during the acute phase of epstein-barr virus. in this study, we evaluated the expression of ksp37 mrna, ... | 2016 | 27032399 |
| epstein-barr virus-associated b-cell lymphoproliferative disorder in a patient with sézary syndrome treated by methotrexate. | 2016 | 27031298 | |
| methylation and expression of epstein-barr virus latent membrane protein 1, 2a and 2b in ebv-associated gastric carcinomas and cell lines. | promoter cpg methylation of epstein-barr virus (ebv) genome plays an essential role in maintaining viral latency. latent membrane protein (lmp) 1, 2a and 2b of ebv exert multiple oncogenic properties by activating multiple signal pathways and modulating the expression of various oncogenes. | 2016 | 27026080 |
| periodic illness associated with epstein-barr virus: a new diagnosis after a 22-year follow-up. | 2016 | 27025823 | |
| circulating interleukin-10 levels and human papilloma virus and epstein-barr virus-associated cancers: evidence from a mendelian randomization meta-analysis based on 11,170 subjects. | recent studies have showed interleukin 10 (il-10) is a critical cytokine that determines antiviral immune response and is related to virus-associated cancers. however, whether genetically elevated circulating il-10 levels are associated with the risk of human papilloma virus and epstein-barr virus-associated cancers (heacs) is still unclear. mendelian randomization method was implemented to meta-analyze available observational studies by employing il-10 three variants (-592c>a, -819c>t, and -108 ... | 2016 | 27022283 |
| gianotti-crosti syndrome as presenting sign of cytomegalovirus infection: a case report and a critical appraisal of its possible cytomegalovirus etiology. | gianotti-crosti syndrome (gcs) is a self-limiting exanthem of acute onset with a characteristic acral distribution, usually occurring in children. it is characterized by symmetric pink to red-brown papular or papulovesicular lesions that are a few millimetres in diameter, distributed on the face, buttocks and limbs. it may be accompanied by low-grade fever, hepato-splenomegaly and lymphadenopathy. gcs is considered a unique cutaneous response to viral infection, mostly associated with hepatitis ... | 2016 | 27017141 |
| primary epstein-barr virus infection, seroconversion, and post-transplant lymphoproliferative disorder in seronegative renal allograft recipients: a prospective cohort study. | epstein-barr virus (ebv)-seronegative renal transplant recipients are at risk of post-transplant lymphoproliferative disorder (ptld). we compared primary ebv infection, seroconversion, and ptld in ebv-seronegative patients who received renal allograft from seropositive or seronegative donors (d+/r- and d-/r-, respectively). | 2016 | 27016725 |
| a case report of nk-cell lymphoproliferative disease with a wide involvement of digestive tract develop into epstein-barr virus associated nk/t cell lymphoma in an immunocompetent patient. | epstein-barr virus (ebv) plays an important role in various diseases. ebv-associated lymphoproliferative disease (lpd) is a rare disease with a canceration tendency. it is difficult to differentiate lpd with involvement of digestive tract from crohn disease due to similar clinical and endoscopic manifestations. we present a case report of multiple ulcers with esophagus, small bowel and the entire colon involved, proved to be nk-cell lpd, developed into ebv-associated nk/t cell lymphoma, in an im ... | 2016 | 27015206 |
| [clinical risks analysis of ebv infection in patients with allogeneic hematopoietic stem cell transplantation]. | to analyze the prevalence of epstein barr virus (ebv) infection in patients following allogeneic hematopoietic stem cell transplantation (allo-hsct). | 2016 | 27014984 |
| the differentiation and protective function of cytolytic cd4 t cells in influenza infection. | cd4 t cells that recognize peptide antigen in the context of class ii mhc can differentiate into various subsets that are characterized by their helper functions. however, increasing evidence indicates that cd4 cells with direct cytolytic activity (cd4 ctl) play a role in chronic as well as acute infections, such as influenza a virus (iav) infection. in the last couple of decades, techniques to measure the frequency and activity of these cytolytic cells has demonstrated their abundance in infect ... | 2016 | 27014272 |
| human herpesviruses as copathogens of hiv infection, their role in hiv transmission, and disease progression. | of eight human herpesviruses (hhvs), often, only herpes simplex virus types 1 (hsv-1) and 2 (hsv-2) find mention in medical literature as both of these viruses are commonly associated with genital lesions and oral ulcers, commonly known as cold sores. however, role of human herpesviruses as copathogens and in aggravation and in the transmission of other human diseases, especially the acquired immunodeficiency syndrome (hiv/aids) has only very recently been recognized. therefore, screening and tr ... | 2017 | 27013807 |
| origin of cystic squamous cell carcinoma metastases in head and neck lymph nodes: addition of ebv testing improves diagnostic accuracy. | most cases of cystic squamous cell carcinoma (scc) metastases in the upper neck are associated with an oropharyngeal primary, namely human papillomavirus (hpv)-associated scc arising in the palatine or lingual tonsil. a retrospective study was performed on 22 patients who presented with cystic head and neck scc metastases. the purpose of the study was to find out whether histological characteristics, p16 protein expression, hpv and epstein-barr virus (ebv) status could be useful in predicting th ... | 2016 | 27013059 |
| hcf1 and oct2 cooperate with ebna1 to enhance orip-dependent transcription and episome maintenance of latent epstein-barr virus. | epstein-barr virus (ebv) establishes latent infections as multicopy episomes with complex patterns of viral gene transcription and chromatin structure. the ebv origin of plasmid replication (orip) has been implicated as a critical control element for viral transcription, as well as viral dna replication and episome maintenance. here, we examine cellular factors that bind orip and regulate histone modification, transcription regulation, and episome maintenance. we found that orip is enriched for ... | 2016 | 27009953 |
| erk2 phosphorylation of ebna1 serine 383 residue is important for ebna1-dependent transactivation. | functional inhibition of epstein-barr virus (ebv)-encoded nuclear antigen 1 (ebna1) can cause the death of ebv infected cells. in this study, a bioinformatics tool predicted the existence of putative extracellular signal-regulated kinase (erk) docking and substrate consensus sites on ebna1, suggesting that erk2 could bind to and phosphorylate ebna1. in accordance, erk2 was found to phosphorylate ebna1 serine 383 in a reaction suppressed by h20 (a structural congener of the erk inhibitor), u0126 ... | 2016 | 27009860 |
| pd-l1 is an independent prognostic predictor in gastric cancer of western patients. | targeting the pd-1/pd-l1 immune checkpoint signaling is a novel promising treatment strategy in several tumor entities, and it is suggested that pd-l1/pd-1 expression is predictive for a pd-1/pd-l1 checkpoint inhibitor treatment response. we investigated the expression of pd-l1 and pd-1 by immunohistochemistry in a large and well characterized gastric cancer (gc) cohort of caucasian patients, consisting of 465 gc samples and 15 corresponding liver metastases. staining results were correlated wit ... | 2016 | 27009855 |
| broadening specificity and enhancing cytotoxicity of adoptive t cells for nasopharyngeal carcinoma immunotherapy. | although promising, clinical responses to adoptive immunotherapy for nasopharyngeal carcinoma (npc) are still limited by the restricted number of epstein-barr virus (ebv) antigens that can be targeted and their poor immunogenicity. our previous work indicated that the immunogenic features of the npc-associated viral antigen barf1 may be exploited for immunotherapeutic purposes. nevertheless, t-cell lines obtained with current protocols include only negligible numbers of barf1-specific cytotoxic ... | 2016 | 27009165 |
| survival analysis of patients with advanced-stage nasopharyngeal carcinoma according to the epstein-barr virus status. | the main aim of this study is to analyze the prognostic differences in nasopharyngeal carcinoma (npc) patients who are positive and negative for epstein-barr virus (ebv). | 2016 | 27008701 |
| [research progress of epstein-barr virus-associated gastric carcinoma]. | epstein-barr virus-associated gastric carcinoma(ebvagc) comprises nearly 10% of gastric carcinoma in the world. ebvagc is supposed to have distinct clinicopathological features, including male predominance, the 'lace pattern' in the early stage, lower rate of lymph node involvement and infiltration of a large number of various inflammatory cells. eber-ish detection is the golden standard in the diagnosis of ebvagc. although there is no special therapy due to the limited understanding, ebvagc has ... | 2016 | 27003661 |
| prevalence of polyoma bk virus (bkpyv), epstein-barr virus (ebv) and human papilloma virus (hpv) in oropharyngeal cancer. | the aim of this study was to analyze the prevalence of bk virus, human papillomavirus and epstein-barr virus in oropharyngeal cancer, and to test our hypothesis that bkv/hpv/ebv co-infection plays a role in oropharyngeal squamous cell carcinoma. the correlation between viral infection, oscc, anatomic location, pre-treatment staging, evidence of metastases to lymph nodes, and grading was also investigated. the examination samples were collected from 62 patients from paraffin tissue blocks. males ... | 2015 | 26999952 |
| high-throughput microdissection for next-generation sequencing. | precision medicine promises to enhance patient treatment through the use of emerging molecular technologies, including genomics, transcriptomics, and proteomics. however, current tools in surgical pathology lack the capability to efficiently isolate specific cell populations in complex tissues/tumors, which can confound molecular results. expression microdissection (xmd) is an immuno-based cell/subcellular isolation tool that procures targets of interest from a cytological or histological specim ... | 2016 | 26999048 |
| vitamin d, hla-drb1 and epstein-barr virus antibody levels in a prospective cohort of multiple sclerosis patients. | our objective was to study the association between serum levels of anti epstein-barr virus nuclear antigen 1 (ebna-1) antibody and 25-hydroxyvitamin d (25(oh)d) in a prospective cohort of patients with relapsing-remitting multiple sclerosis. | 2016 | 26998820 |
| lymphoepithelioma-like gastric carcinoma located in the lesser curvature of the gastric body: a case report and review of the literature. | lymphoepithelioma-like gastric carcinoma (lelc) is a type of epstein-barr virus (ebv)-associated gastric cancer, characterized by the presence of a lymphoid stroma with cells arranged primarily in microalveolar, thin trabecular and primitive tubular patterns, or isolated cells. in situ hybridization is usually used to confirm the presence of ebv. lelc is a rare type of cancer, with an incidence of 1-4% among all gastric cancers. despite its rarity, this tumor has attracted attention due to its d ... | 2016 | 26998292 |
| herpes and polyoma family viruses in thyroid cancer. | thyroid cancer is considered the most common malignancy that affects the endocrine system. generally, thyroid cancer derives from follicular epithelial cells, and thyroid cancer is divided into well-differentiated papillary (80% of cases) and follicular (15% of cases) carcinoma. follicular thyroid cancer is further divided into the conventional and oncocytic (hürthle cell) type, poorly differentiated carcinoma and anaplastic carcinoma. both poorly differentiated and anaplastic carcinoma can aris ... | 2016 | 26998055 |
| mature t- and nk-cell non-hodgkin lymphoma in children and young adolescents. | mature t/natural killer (nk)-cell neoplasms of children and the young adolescent population exhibit higher prevalence in central and south american and asian populations and many are associated with epstein-barr virus (ebv). they are represented in large part by extranodal t/nk cell lymphomas- nasal-type or extra nasal-type, chronic lymphoproliferative disorders of t/nk cells or chronic active ebv disease, systemic ebv-positive lymphoproliferative disorders of childhood, hydroa vacciniforme-like ... | 2016 | 26992145 |
| role of epstein-barr virus status and immunophenotypic studies in the evaluation of exfoliative cytology specimens from patients with post-transplant lymphoproliferative disorders. | post-transplant lymphoproliferative disorders (ptlds) are well characterized in tissue sections, but their evaluation in exfoliative cytology specimens is limited. this study reports a 25-year experience with ptlds in exfoliative cytology specimens. | 2016 | 26992116 |
| identification of igh gene rearrangement and immunophenotype in an animal model of epstein-barr virus-associated lymphomas. | epstein-barr virus (ebv) is a human oncogenic herpesvirus associated with lymphoma and nasopharyngeal carcinoma. because the susceptible hosts of eb virus are limited to human and cotton-top tamarins (saguinus oedipus), there have been no appropriate animal models until the lymphoma model induced by ebv in human peripheral blood lymphocyte (hu-pbl)/scid chimeric mice was reported. however, it is still controversial whether the ebv-associated lymphoma induced in hu-pbl/scid mice is a monoclonal t ... | 2016 | 26991077 |
| methylation of epstein-barr virus rta promoter in ebv primary infection, reactivation and lymphoproliferation. | during epstein-barr virus (ebv) latency, the ebv genome is largely silenced by methylation. this silencing is overturned during the switch to the lytic cycle. a key event is the production of the viral protein zta which binds to three zta-response elements (zre) from the rta promoter (rp), two of which (zre2 and zre3) include three cpg motifs methylated in the latent genome. the bisulphite pyrosequencing reaction was used to quantify the methylation of zre2, zre3a, and zre3b in ebv-positive cell ... | 2016 | 26990870 |
| ebv seroepidemiology in married and unmarried women and men in iran. | among the eight known human herpes viruses, epstein- barr virus (ebv) is considered to be sexually transmissible. this study was conducted to evaluate the seroepidemiology of this infection in married and unmarried iranian couples. | 2014 | 26989728 |
| analysis of epstein-barr virus infection models in a series of pediatric carriers from a developing country. | epstein-barr virus (ebv) is a b lymphotropic human herpesvirus. two models, germinal center (gc) and direct infection, describe how ebv infects b-cells. since in argentina primary infection is mostly subclinical at young ages, children represent an interesting population where to analyze ebv infection, especially considering that most studies are usually performed in adults. tonsil biopsies from pediatric carriers were studied to describe infection characteristics. ebv+ lymphocytes at the interf ... | 2016 | 26988293 |
| haplotypes of the d-amino acid oxidase gene are significantly associated with schizophrenia and its neurocognitive deficits. | d-amino acid oxidase (dao) has been reported to be associated with schizophrenia. this study aimed to search for genetic variants associated with this gene. the genomic regions of all exons, highly conserved regions of introns, and promoters of this gene were sequenced. potentially meaningful single-nucleotide polymorphisms (snps) obtained from direct sequencing were selected for genotyping in 600 controls and 912 patients with schizophrenia and in a replicated sample consisting of 388 patients ... | 2016 | 26986737 |
| how compelling are the data for epstein-barr virus being a trigger for systemic lupus and other autoimmune diseases? | systemic lupus erythematosus (sle) is caused by a combination of genetic and acquired immunodeficiencies and environmental factors including infections. an association with epstein-barr virus (ebv) has been established by numerous studies over the past decades. here, we review recent experimental studies on ebv, and present our integrated theory of sle development. | 2016 | 26986247 |
| disseminated mycobacterium marinum infection with a destructive nasal lesion mimicking extranodal nk/t cell lymphoma: a case report. | mycobacterium marinum is a ubiquitous waterborne organism that mainly causes skin infection in immunocompetent patients, and its disseminated infection is rare. extranodal nk/t cell lymphoma, nasal type (enkl) usually localizes at the nasal and/or paranasal area, but occasionally disseminates into the skin/soft tissue and gastrointestinal tract. compromised immunity is a risk factor for developing nontuberculous mycobacterial (ntm) infection and malignant lymphoma, and the 2 diseases may share s ... | 2016 | 26986167 |
| the split renilla luciferase complementation assay is useful for identifying the interaction of epstein-barr virus protein kinase bglf4 and a heat shock protein hsp90. | protein-protein interactions can regulate different cellular processes, such as transcription, translation, and oncogenic transformation. the split renilla luciferase complementation assay (srlca) is one of the techniques that detect protein-protein interactions. the srlca is based on the complementation of the ln and lc non-functional halves of renilla luciferase fused to possibly interacting proteins which after interaction form a functional enzyme and emit luminescence. the bglf4 of epstein-b ... | 2016 | 26982469 |
| macular amyloidosis and epstein-barr virus. | background. amyloidosis is extracellular precipitation of eosinophilic hyaline material of self-origin with special staining features and fibrillar ultrastructure. macular amyloidosis is limited to the skin, and several factors have been proposed for its pathogenesis. detection of epstein-barr virus (ebv) dna in this lesion suggests that this virus can play a role in pathogenesis of this disease. objective. ebv dna detection was done on 30 skin samples with a diagnosis of macular amyloidosis and ... | 2016 | 26981113 |
| epstein-barr virus and its association with rheumatoid arthritis and oral lichen planus. | pathogenesis of autoimmune diseases (ad) is one of a multifactorial milieu. a genetic predisposition, an immune system failure, hormonal imbalance and environmental factors play important roles. among the many environmental factors, the role of infection is gaining importance in the pathogenesis of various autoimmune disorders; among them, epstein-barr virus (ebv) plays a pivotal role. literature states an association of various ad with ebv namely multiple sclerosis, autoimmune thyroiditis, syst ... | 2017 | 26980953 |
| using structural-based protein engineering to modulate the differential inhibition effects of saugi on human and hsv uracil dna glycosylase. | uracil-dna glycosylases (udgs) are highly conserved proteins that can be found in a wide range of organisms, and are involved in the dna repair and host defense systems. udg activity is controlled by various cellular factors, including the uracil-dna glycosylase inhibitors, which are dna mimic proteins that prevent the dna binding sites of udgs from interacting with their dna substrate. to date, only three uracil-dna glycosylase inhibitors, phage ugi, p56, and staphylococcus aureus saugi, have b ... | 2016 | 26980279 |
| expression and prognostic roles of pik3ca, jak2, pd-l1, and pd-l2 in epstein-barr virus-associated gastric carcinoma. | as a special subtype of gastric carcinoma, epstein-barr virus (ebv)-associated gastric carcinoma (ebvagc) has distinct clinicopathological features. the cancer genome atlas research network revealed that ebvagc also has distinct molecular features: pik3ca mutations, dna hypermethylation, and jak2, pd-l1, and pd-l2 amplification. here, we evaluated pik3ca, jak2, pd-l1, and pd-l2 expression in 59 ebvagc and 796 ebv-negative gastric carcinoma (ebvngc) cases using immunohistochemistry and found that ... | 2016 | 26980034 |
| role of viral mirnas and epigenetic modifications in epstein-barr virus-associated gastric carcinogenesis. | micrornas are short (21-23 nucleotides), noncoding rnas that typically silence posttranscriptional gene expression through interaction with target messenger rnas. currently, mirnas have been identified in almost all studied multicellular eukaryotes in the plant and animal kingdoms. additionally, recent studies reported that mirnas can also be encoded by certain single-cell eukaryotes and by viruses. the vast majority of viral mirnas are encoded by the herpesviruses family. these dna viruses incl ... | 2016 | 26977250 |
| spironolactone blocks epstein-barr virus production by inhibiting ebv sm protein function. | clinically available drugs active against epstein-barr virus (ebv) and other human herpesviruses are limited to those targeting viral dna replication. to identify compounds directed against other steps in the viral life cycle, we searched for drugs active against the ebv sm protein, which is essential for infectious virus production. sm has a highly gene-specific mode of action and preferentially enhances expression of several late lytic cycle ebv genes. here we demonstrate that spironolactone, ... | 2016 | 26976570 |
| chronic unexplained fatigue. | fatigue is a common symptom in the community and the commonest associations are with stress or mood disturbance. one in a hundred people complain of unexplained and prolonged fatigue, with half that number meeting the strictest criteria for the chronic fatigue syndrome (cfs). discrete fatigue syndromes have been described, particularly after epstein barr virus infection. the majority of patients with cfs have a syndrome similar to the icd-10 definition of neurasthenia. mood and somatoform disord ... | 1999 | 26976541 |
| de novo proliferative glomerulonephritis with monoclonal igg deposits of the igg1κ subtype in a kidney allograft. | proliferative glomerulonephritis with monoclonal immunoglobulin g (igg) deposits (pgnmid) has recently been described in cases with glomerular disease. only 16 cases of recurrent or de novo pgnmid have been reported in the transplanted kidney. here we report a case of de novo pgnmid in a renal allograft diagnosed in the early stage by protocol biopsy. a 41-year-old male with end-stage kidney disease caused by focal glomerular sclerosis received a living-related kidney transplant. the post-transp ... | 2016 | 26976360 |
| demonstration of herpes simplex virus, cytomegalovirus, and epstein-barr virus in colorectal cancer. | the present study sought to investigate molecular evidence for association between the presence of herpes simplex virus (hsv), cytomegalovirus (cmv), and epstein-barr virus (ebv) in crc and colorectal polyp by using the pcr method in iran. | 2016 | 26975327 |
| lymphoepithelioma-like gastric carcinoma: a case report and review of the literature. | lymphoepithelioma-like gastric carcinoma is a rare type of gastric cancer characterized by a carcinoma with intense stromal lymphocytic infiltration. although lymphocytic infiltration is closely associated with epstein-barr virus (ebv) infection, concomitant occurrence with differentiated adenocarcinoma is relatively rare. the clinical manifestations of lymphoepithelioma-like gastric carcinoma (including ebv-positive and -negative forms) are similar to those of gastric cancer, and the diagnosis ... | 2016 | 26973402 |
| meta-analysis of genome-wide association studies reveals genetic overlap between hodgkin lymphoma and multiple sclerosis. | based on epidemiological commonalities, multiple sclerosis (ms) and hodgkin lymphoma (hl), two clinically distinct conditions, have long been suspected to be aetiologically related. ms and hl occur in roughly the same age groups, both are associated with epstein-barr virus infection and ultraviolet (uv) light exposure, and they cluster mutually in families (though not in individuals). we speculated if in addition to sharing environmental risk factors, ms and hl were also genetically related. usi ... | 2016 | 26971321 |
| comprehensive profiling of ebv gene expression in nasopharyngeal carcinoma through paired-end transcriptome sequencing. | the latent expression pattern of epstein-barr virus (ebv) genes in nasopharyngeal carcinoma (npc) has been extensively investigated, and the expression of several lytic genes in npc has been reported. however, comprehensive information through ebv transcriptome analysis in npc is limited. we performed paired-end rna-seq to systematically and comprehensively characterize the expression of ebv genes in npc tissue and c666-1 npc cell line, which consistently carries ebv. in addition to the transcri ... | 2016 | 26969667 |
| the natural history of human polyomaviruses and herpesviruses in early life--the rhea birth cohort in greece. | sparse data exist on the patterns and determinants of acquisition of polyomaviruses and herpesviruses in childhood. we measured immunoglobulin g seroreactivity against 10 polyomaviruses (bkpyv, jcpyv, kipyv, wupyv, mcpyv, hpyv6, hpyv7, tspyv, hpyv9, hpyv10) and 5 herpesviruses (epstein barr virus (ebv), cytomegalovirus (cmv), herpes simplex virus types 1 and 2, human herpesvirus 8) using multiplex serology on blood samples collected at birth (cord blood, n = 626) and at follow-up at 3 years (n = ... | 2016 | 26968942 |
| ebv reactivation as a target of luteolin to repress npc tumorigenesis. | nasopharyngeal carcinoma (npc) is a malignancy derived from the epithelial cells of the nasopharynx. although a combination of radiotherapy with chemotherapy is effective for therapy, relapse and metastasis after remission remain major causes of mortality. epstein-barr virus (ebv) is believed to be one of causes of npc development. we demonstrated previously that ebv reactivation is important for the carcinogenesis of npc. we sought, therefore, to determine whether ebv reactivation can be a targ ... | 2016 | 26967558 |
| lymphomatoid granulomatosis with paraneoplastic polymyositis: a rare malignancy with rare complication. | lymphomatoid granulomatosis is a rare epstein-barr virus driven lymphoproliferative disease. it most commonly presents with symptoms of lung involvement such as cough, chest tightness, and dyspnea or constitutional symptoms of weight loss, malaise, and fever. the diagnosis is obtained by biopsy and histopathology. here we report the case of a 31-year-old male who presented with weight loss, rash, and weakness and was diagnosed with lymphomatoid granulomatosis with paraneoplastic polymyositis. we ... | 2016 | 26966605 |
| epstein-barr virus encephalitis with substantia nigra involvement. | infectious mononucleosis due to epstein-barr virus (ebv) is a usually benign systemic viral illness common in children. many studies described nervous system manifestations of infectious mononucleosis with a wide spectrum of neurologic deficits. neurologic complications of ebv are seen in both acute and reactivate infection. herein, we describe a patient diagnosed by acute ebv encephalitis with substantia nigra involvement and excellent clinical recovery. | 2017 | 26962357 |
| iatrogenic immunodeficiency-associated lymphoproliferative disorders in transplant and nontransplant settings. | iatrogenic immunodeficiency-associated lymphoproliferative disorders comprise a group of lymphoid neoplasms that are associated with an immunosuppressed state, either in the posttransplant period, or during the treatment of various autoimmune and rheumatologic disorders by immunomodulatory medications. their morphologies vary widely but are generally classified according to the lymphomas that they most closely resemble. this group is strongly associated with infections by the epstein-barr virus ... | 2017 | 26960627 |
| epstein-barr virus-positive t-cell lymphoproliferative disease following umbilical cord blood transplantation for acute myeloid leukemia. | we report a case of the extremely rare condition epstein-barr virus (ebv)-positive t-cell lymphoproliferative disease (lpd) which occurred after umbilical cord blood transplantation. a 25-year-old japanese man underwent cord blood transplantation from a male human leukocyte antigen 4/6-matched donor due to acute myeloid leukemia with trisomy 8. bone marrow examination on day 30 showed chimerism with at least 90% donor cells and complete hematological response. chronic symptoms of graft-versus-ho ... | 2016 | 26960588 |
| plasmablastic lymphoma in hiv patients: experience at a tertiary care hospital in eastern india. | plasmablastic lymphoma (pbl), a rare non-hodgkin's lymphoma (nhl) variant specifically associated with human immunodeficiency virus/acquired immunodeficiency syndrome (hiv/aids), expresses well-differentiated plasma cell markers like cd138, bright cd38, and mum1; but not conventional b-cell markers. it occurs at unusual sites like oral cavity and orbit, and has poor survival rates. | 2016 | 26960478 |
| [analysis of clinical characteristics of hypoxic hepatitis in children]. | to explore the etiology and clinical characteristics of hypoxic hepatitis (hh) in children. | 2016 | 26957066 |
| epstein barr virus and mycobacterium avium subsp. paratuberculosis peptides are recognized in sera and cerebrospinal fluid of ms patients. | mycobacterium avium subsp. paratuberculosis (map) and epstein-barr virus (ebv) epitopes elicit a consistent humoral response in serum of multiple sclerosis patients, but the cross reactivity against the homologous myelin basic protein (mbp) and human interferon regulatory factor 5 (irf5) has not been searched within the cerebral spinal fluid (csf). we evaluated in sera and csf of patients with ms and with other neurological diseases (ond) the humoral response against ebv/map peptides and the irf ... | 2016 | 26956729 |
| methotrexate-associated ebv-positive vasculitis in the skin: a report of two cases simulating rheumatoid vasculitis. | rheumatoid vasculitis (rv) is one of the most serious extra-articular complications of rheumatoid arthritis (ra), generally treated with a high dose of immunosuppressive drugs. recently, we encountered two cases of ulcerative vasculitis in methotrexate (mtx)-prescribed ra patients, which simulated rv; however, epstein-barr virus (ebv)-encoded rna in situ hybridization on their skin biopsies revealed many ebv-positive lymphocytes (over 50 cells/high-power field) within the vessel walls and periva ... | 2016 | 26955985 |
| novel insights into the early histopathogenesis of immunodeficiency-associated burkitt lymphoma: a case report of burkitt microlymphoma arising within hiv lymphadenitis. | to report a case detailing the early histopathogenesis of burkitt lymphoma (bl), epstein-barr virus (ebv) positive, in the clinical setting of hiv infection. | 2016 | 26953628 |
| chronic active ebv infection with features of granulomatosis with polyangiitis. | herein, we report the case of a 13-year-old boy with multiple recurrent ulcers on his legs. he developed severe sinusitis at 10 years of age and had significant weight loss (6 kg) in the 2 months prior to admission. histology of tissue biopsied from the ulcer indicated small vessel vasculitis and granulomatous inflammation. given that these findings met the diagnostic criteria for granulomatosis with polyangiitis (gpa), he was treated with immunosuppressive agents. further pathology, however, in ... | 2016 | 26952849 |
| ebv noncoding rna eber2 interacts with host rna-binding proteins to regulate viral gene expression. | epstein-barr virus (ebv) produces a highly abundant noncoding rna called ebv-encoded rna 2 (eber2) that interacts indirectly with the host transcription factor paired box protein 5 (pax5) to regulate viral latent membrane protein 1/2 (lmp1/2) gene expression as well as ebv lytic replication. to identify intermediary proteins, we isolated eber2-pax5-containing complexes and analyzed the protein components by mass spectrometry. the top candidates include three host proteins splicing factor proline ... | 2016 | 26951683 |
| whole-exome sequencing identifies mst1r as a genetic susceptibility gene in nasopharyngeal carcinoma. | multiple factors, including host genetics, environmental factors, and epstein-barr virus (ebv) infection, contribute to nasopharyngeal carcinoma (npc) development. to identify genetic susceptibility genes for npc, a whole-exome sequencing (wes) study was performed in 161 npc cases and 895 controls of southern chinese descent. the gene-based burden test discovered an association between macrophage-stimulating 1 receptor (mst1r) and npc. we identified 13 independent cases carrying the mst1r pathog ... | 2016 | 26951679 |
| [progress on the function of herpesvirus-encoded micrornas]. | since epstein barr virus was shown to encode micrornas(mirnas) in 2004, more than 470 mirnas have been discovered in α-, β-, and γ-herpesviruses. mirnas are small non-coding rna molecules and generally only have 18-25 nucleotides in length, which can regulate the expression of target genes by targeting its transcripts. herpesvirus-encoded mirnas not only target the key genes from latency to lytic replication, but also regulate various host cellular genes. current data manifest that herpesvirus-e ... | 2015 | 26951018 |
| severe skin complications after small bowel transplantation: graft-versus-host disease, dress, virus, or drug toxicity? | severe skin problems are uncommon after small bowel transplantation. differential diagnosis includes drug reactions, infections, graft-versus-host disease (gvhd), and mixed diseases. early diagnosis and treatment are determinant for prognosis. | 2016 | 26950725 |
| gastric adenocarcinoma microrna profiles in fixed tissue and in plasma reveal cancer-associated and epstein-barr virus-related expression patterns. | microrna expression in formalin-fixed paraffin-embedded tissue (ffpe) or plasma may add value for cancer management. the gastrogenus mir panel was developed to measure 55 cancer-specific human micrornas, epstein-barr virus (ebv)-encoded micrornas, and controls. this q-rtpcr panel was applied to 100 ffpes enriched for adenocarcinoma or adjacent non-malignant mucosa, and to plasma of 31 patients. in ffpe, micrornas upregulated in malignant versus adjacent benign gastric mucosa were hsa-mir-21, -15 ... | 2016 | 26950485 |
| extreme hypertriglyceridemia in an infant with hemophagocytic lymphohistiocytosis and hydroxycobalamin deficiency. | hemophagocytic lymphohistiocytosis (hlh) is a severe hyperinflammatory condition characterized by fever, cytopenias, hepatosplenomegaly and hemophagocytosis. hlh may be primary or secondary to infection, autoimmune disease or malignancy. hypertriglyceridemia is a common abnormality in hlh and one of the hlh-2004 diagnostic criteria. | 2016 | 26946773 |
| disseminated anetoderma in a patient with nodal epstein-barr virus-associated classical hodgkin lymphoma: anetodermic form of a concurrent discordant cutaneous marginal zone lymphoma. | patients with a lymphoma have an increased risk of developing a second lymphoproliferative disorder. the association of nodal hodgkin lymphoma and primary cutaneous marginal zone lymphoma (malt type) is exceptional, and only very few cases have been documented. anetoderma represents a circumscribed loss or rarefication of elastic fibers. different underlying processes may result in anetoderma, including cutaneous marginal zone lymphoma. we report a 50-year-old male patient with epstein-barr viru ... | 2016 | 26945704 |
| comparison of clinicopathologic parameters and survivals between epstein-barr virus-positive and her2-positive gastric cancers. | gastric carcinomas are highly mortal neoplasms for which new therapeutic options are being searched. the molecular subtyping of gastric adenocarcinomas was proposed recently, and the relationship between etiopathogenetic types is still under investigation. here we compared histopathologic, prognostic, and survival differences between epstein-barr virus (ebv)-positive and her2-positive gastric adenocarcinomas. in a retrospective design, we searched the ebv status with epstein barr virus encoded s ... | 2016 | 26945448 |
| epstein-barr virus hemorrhagic meningoencephalitis: case report and review of the literature. | neurologic complications related to epstein-barr virus (ebv) in immunocompetent adults are rare and most commonly self-limited. however, severe cases have been previously reported in the literature. we describe a case of meningoencephalitis with frontal bilateral hemorrhage in a non-immunocompromised adult following an ebv infection of the central nervous system confirmed by the presence of ebv-dna in the cerebrospinal fluid. during the patient's hospital stay, there was a favorable clinical and ... | 2016 | 26942617 |
| phase i clinical trial of 4-1bb-based adoptive t-cell therapy for epstein-barr virus (ebv)-positive tumors. | although adoptive cell therapy using ag-specific t cells has been tested successfully in the clinic, the production of these t cells has been challenging. by applying our simple and practical 4-1bb-based method for the generation of ag-specific cd8 t cells, here we determined the maximum tolerated dose, toxicity profile, immunologic responses, and clinical efficacy of autologous epstein-barr virus (ebv)/lmp2a-specific cd8 t cells (ebv-induced natural t cell; ebvint) in patients with relapsed/ref ... | 2016 | 26938947 |
| new cd20 alternative splice variants: molecular identification and differential expression within hematological b cell malignancies. | cd20 is a b cell lineage-specific marker expressed by normal and leukemic b cells and targeted by several antibody immunotherapies. we have previously shown that the protein from a cd20 mrna splice variant (d393-cd20) is expressed at various levels in leukemic b cells or lymphoma b cells but not in resting, sorted b cells from the peripheral blood of healthy donors. | 2015 | 26937306 |
| generation of human monoclonal autoantibody-producing cell lines by epstein-barr virus transformation of autoreactive b lymphocytes and by somatic cell hybridization techniques: application to the analysis of the autoimmune b cell repertoire. | epstein-barr virus (ebv) was used to immortalize human peripheral b lymphocytes committed to the production of autoantibodies in healthy subjects and in patients with various autoimmune diseases. ebv-transformed b lymphocytes producing human monoclonal autoantibodies were fused with the human-mouse heterohybridoma f3b6 cells to stabilize the production of monoclonal antibodies (mab). the present method of generating human b cell clones producing mabs now makes it possible to analyze in detail th ... | 1992 | 26937163 |
| epstein-barr virus neurologic complications. | investigators at the karol marcinkowski university of medical sciences, poznan, poland, analyzed the records of 194 children diagnosed with epstein-barr virus infection and having the viral capsid antigen igm antibody. | 2015 | 26933545 |
| valpromide inhibits lytic cycle reactivation of epstein-barr virus. | reactivation of epstein-barr virus (ebv) from latency into the lytic phase of its life cycle allows the virus to spread among cells and between hosts. valproic acid (vpa) inhibits initiation of the lytic cycle in ebv-infected b lymphoma cells. while vpa blocks viral lytic gene expression, it induces expression of many cellular genes, because it is a histone deacetylase (hdac) inhibitor. here we show, using derivatives of vpa, that blockade of ebv reactivation is separable from hdac inhibition. v ... | 2016 | 26933051 |
| novel targets in the treatment of advanced gastric cancer: a perspective review. | gastric cancer is responsible for a high burden of disease globally. although more extensive use of chemotherapy together with the recent introduction of the two targeted agents trastuzumab and ramucirumab have contributed to marginal outcome prolongation, overall survival for patients with advanced stage disease remains poor. over the last decade, a number of novel agents have been examined in clinical trials with largely disappointing results. potential explanations for this are the absence of ... | 2016 | 26929787 |
| macrophage inflammatory protein 1 alpha (mip-1α) may be associated with poor outcome in patients with extranodal nk/t-cell lymphoma. | the macrophage inflammatory protein 1α (mip-1α) is anticipated to have a role in extranodal natural killer (nk)/t-cell lymphoma (enktl) because the expression of mip-1α is related to epstein-barr virus (ebv) latency in ebv-related non-hodgkin lymphoma cells. thus, we measured the serum level of mip-1α in 69 patients with enktl using frozen serum samples that were archived at diagnosis. as serum level of mip-1α was not detectable in 19 patients (range: 0-24.37 pg/ml), patients were dichotomized i ... | 2016 | 26928433 |
| from conventional to next generation sequencing of epstein-barr virus genomes. | genomic sequences of epstein-barr virus (ebv) have been of interest because the virus is associated with cancers, such as nasopharyngeal carcinoma, and conditions such as infectious mononucleosis. the progress of whole-genome ebv sequencing has been limited by the inefficiency and cost of the first-generation sequencing technology. with the advancement of next-generation sequencing (ngs) and target enrichment strategies, increasing number of ebv genomes has been published. these genomes were seq ... | 2016 | 26927157 |
| artificial antigen-presenting cells expressing hla class ii molecules as an effective tool for amplifying human specific memory cd4(+) t cells. | owing to their multiple immune functions, cd4(+) t cells are of major interest for immunotherapy in chronic viral infections and cancer, as well as for severe autoimmune diseases and transplantation. therefore, standardized methods allowing rapid generation of a large number of cd4(+) t cells for adoptive immunotherapy are still awaited. we constructed stable artificial antigen-presenting cells (aapcs) derived from mouse fibroblasts. they were genetically modified to express human leukocyte anti ... | 2016 | 26924643 |
| prognostic impact of plasma epstein-barr virus dna in patients with nasopharyngeal carcinoma treated using intensity-modulated radiation therapy. | the prognostic value of plasma epstein-barr virus (ebv) dna remains unknown in nasopharyngeal carcinoma (npc) treated with intensity-modulated radiation therapy (imrt). we retrospectively reviewed medical records of 584 newly diagnosed patients with nonmetastatic and biopsy-proven npc treated using imrt. plasma ebv dna concentration was measured before therapy (pre-dna) and within 1 month of completing therapy (post-dna) using real-time quantitative polymerase chain reaction. receiver operating ... | 2016 | 26924234 |
| comparative proteomics analysis of apoptotic spodoptera frugiperda cells during p35 knockout autographa californica multiple nucleopolyhedrovirus infection. | infection with autographa californica multiple nucleopolyhedrovirus (acmnpv) mutants lacking a functional p35 gene can induce host cell apoptosis, which provides the possibility to use the potential of these viruses in the biological control of pest insects. nonetheless, the proteomics or the protein changes of spodoptera frugiperda (sf9) cells infected with p35 knockout acmnpv have not yet been studied. to further improve the use of acmnpv, we set out to analyze the protein composition and prot ... | 2016 | 26922645 |
| caspase-dependent cleavage regulates protein levels of epstein-barr virus-derived latent membrane protein 1. | epstein-barr virus (ebv)-encoded latent membrane protein-1 (lmp1) plays pathogenic roles in ebv-related diseases. thus, host cells employ several mechanisms to regulate lmp1 functions, and we previously reported possible regulation by signal transducing adaptor protein-2 as well as bs69. here, we found that caspase-3 mainly degraded lmp1 proteins in hela cells, leading to decreased nf-κb and stat3 activation. caspase-3 cleaved the consensus dntd sequences in the ctar3 region of lmp1. of importan ... | 2016 | 26921582 |
| high levels of antibody that neutralize b-cell infection of epstein-barr virus and that bind ebv gp350 are associated with a lower risk of nasopharyngeal carcinoma. | elevated iga antibodies indicative of ongoing exposure to epstein-barr virus (ebv) are high-risk biomarkers for nasopharyngeal carcinoma (npc), an ebv-related epithelial tumor. however, protective biomarkers that limit exposure to the virus have not been defined. we evaluated whether antibodies that can neutralize ebv infection by targeting glycoproteins involved in viral cell entry, including ebv vaccine candidate glycoprotein 350 (gp350), were associated with lower npc risk. | 2016 | 26920891 |
| cigarette smoking complements the prognostic value of baseline plasma epstein-barr virus deoxyribonucleic acid in patients with nasopharyngeal carcinoma undergoing intensity-modulated radiation therapy: a large-scale retrospective cohort study. | we evaluated the combined prognostic value of cigarette smoking and baseline plasma epstein-barr virus deoxyribonucleic acid (ebv dna) in patients with nasopharyngeal carcinoma (npc) treated with intensity-modulated radiation therapy (imrt). of consecutive patients, 1501 with complete data were eligible for retrospective analysis. smoking index (si; cigarette packs per day times smoking duration [years]), was used to evaluate the cumulative effect of smoking. primary end-point was overall surviv ... | 2016 | 26919237 |
| prospective characterization of the risk factors for transmission and symptoms of primary human herpesvirus infections among ugandan infants. | human herpesvirus (hhv) infections are common during infancy. primary infections are frequently asymptomatic and best studied prospectively by using direct viral detection. | 2016 | 26917575 |