Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| unusual presentation of rosai-dorfman disease in a 14-month-old italian child: a case report and review of the literature. | rosai-dorfman disease (rdd) is a rare form of histiocytosis characterized by histiocyte proliferation within lymph nodes and extranodal tissue. here we report an unusual presentation of rdd in an italian toddler. moreover, we reviewed the pediatric case reports published between 2004 and 2014, focusing in particular on medical therapy. | 2016 | 27142277 |
| antibody producing b lineage cells invade the central nervous system predominantly at the time of and triggered by acute epstein-barr virus infection: a hypothesis on the origin of intrathecal immunoglobulin synthesis in multiple sclerosis. | patients with multiple sclerosis (ms), a chronic inflammatory disease of the central nervous system (cns), typically have an intrathecal synthesis of immunoglobulin (ig)g. intrathecal igg is produced by b lineage cells that entered the cns, but why and when these cells invade the cns of patients with ms is unknown. the intrathecal igg response in patients with ms is polyspecific and part of it is directed against different common viruses (e.g. measles virus, rubella virus, varicella zoster virus ... | 2016 | 27142157 |
| a case of primary pulmonary nk/t cell lymphoma presenting as pneumonia. | primary pulmonary lymphoma, particularly non-b cell lymphomas involving lung parenchyma, is very rare. a 46-year-old male was admitted to the hospital with fever and cough. chest x-ray showed left lower lobe consolidation, which was considered pneumonia. however, because the patient showed no response to empirical antibiotic therapy, bronchoscopic biopsy was performed for proper diagnosis. the biopsied specimen showed infiltrated atypical lymphocytes with angiocentric appearance. on immunohistoc ... | 2016 | 27141431 |
| mathematical modeling of the cells repair regulations in nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is a malignant cancer which is caused by the activation of epstein-barr virus (ebv) via some external factors. in the cells repair regulations, the p53 gene mutation can be used as the early indication of the npc growth. the npc growth is due to the dna damage accumulation caused by the ebv infection. in this paper we construct the cells repair regulations model to characterize the npc growth. the model is a 15 dimensional of first order ode system and consists the ... | 2016 | 27140528 |
| human herpesviruses respiratory infections in patients with acute respiratory distress (ards). | acute respiratory distress syndrome (ards) is today a leading cause of hospitalization in intensive care unit (icu). ards and pneumonia are closely related to critically ill patients; however, the etiologic agent is not always identified. the presence of human herpes simplex virus 1, human cytomegalovirus and epstein-barr virus in respiratory samples of critically ill patients is increasingly reported even without canonical immunosuppression. the main aim of this study was to better understand t ... | 2016 | 27138606 |
| ebna1 antigen-specific cd8+ t cells in cerebrospinal fluid of patients with multiple sclerosis. | epidemiological data suggests that epstein-barr virus may be involved in the pathogenesis of multiple sclerosis (ms). we aimed to determine the frequency of cd8+ t cells specific for one ebna1-derived epitope (hpvgeadyfey) in cerebrospinal fluid (csf) and blood of patients with ms and other inflammatory neurological diseases (oind). the frequency of specific cd8+ t cells was assessed by hla-class-i-binding pentamers restricted to hla-b35. the frequency of hpvgeadyfey-specific cd8+ t cells did ne ... | 2016 | 27138093 |
| distribution and molecular characterization of human adenovirus and epstein-barr virus infections in tonsillar lymphocytes isolated from patients diagnosed with tonsillar diseases. | surgically removed palatine tonsils provide a conveniently accessible source of t and b lymphocytes to study the interplay between foreign pathogens and the host immune system. in this study we have characterised the distribution of human adenovirus (hadv), epstein-barr virus (ebv) and human cytomegalovirus (hcmv) in purified tonsillar t and b cell-enriched fractions isolated from three patient age groups diagnosed with tonsillar hypertrophy and chronic/recurrent tonsillitis. hadv dna was detect ... | 2016 | 27136093 |
| factors influencing survival among kenyan children diagnosed with endemic burkitt lymphoma between 2003 and 2011: a historical cohort study. | discovering how to improve survival and establishing clinical reference points for children diagnosed with endemic burkitt lymphoma (ebl) in resource-constrained settings has recaptured international attention. using multivariate analyses, we evaluated 428 children with ebl in kenya for age, gender, tumor stage, nutritional status, hemoglobin, lactate dehydrogenase (ldh), epstein-barr virus (ebv) and plasmodium falciparum prior to induction of chemotherapy (cyclophosphamide, vincristine, methotr ... | 2016 | 27136063 |
| ileo-ileal intussusception and bowel obstruction caused by plasmablastic lymphoma of small bowel- a rare entity in rare location. | intussusception of small bowel is considered a rare cause of bowel obstruction in adults accounting for only about 1% of bowel obstruction in adults. intussusception in adults is uncommon with 95% cases of intussusceptions occurring in children. adult intussusception from small intestinal lymphoma is also rare with only 36 cases reported in the literature between 2000 and 2011. plasmablastic lymphoma (pbl) is an aggressive lymphoid neoplasm usually seen in the oral cavity in the clinical setting ... | 2016 | 27134931 |
| herpesvirus infections and risk of frailty and mortality in older women: women's health and aging studies. | to examine the relationship between herpesvirus infections and mortality and incident frailty risks in community-dwelling older women. | 2016 | 27131018 |
| global mapping of o-glycosylation of varicella zoster virus, human cytomegalovirus, and epstein-barr virus. | herpesviruses are among the most complex and widespread viruses, infection and propagation of which depend on envelope proteins. these proteins serve as mediators of cell entry as well as modulators of the immune response and are attractive vaccine targets. although envelope proteins are known to carry glycans, little is known about the distribution, nature, and functions of these modifications. this is particularly true for o-glycans; thus we have recently developed a "bottom up" mass spectrome ... | 2016 | 27129252 |
| diagnostic and therapeutic challenges of ebv-positive mucocutaneous ulcer: a case report and systematic review of the literature. | epstein-barr virus-positive mucocutaneous ulcer (ebvmcu) is a recently recognized b cell lymphoproliferative disorder that is driven by latent ebv infection and causes discrete ulcerations in the oropharynx, gastrointestinal tract, and skin. local attenuation of immunosurveillance associated with iatrogenic immunosuppressant use, primary immunodeficiency, or age-associated immunosenescence has been implicated as a predisposing factor. this disorder is likely under reported, as it was only first ... | 2015 | 27127726 |
| cd4-positive t-cell primary central nervous system lymphoma in an hiv positive patient. | primary central nervous system lymphomas (pcnsls) in patients with human immunodeficiency virus (hiv) are predominantly b-cell lymphomas associated with epstein-barr virus (ebv) and rarely cd8-positive t-cell pcnsls. | 2016 | 27124906 |
| spontaneous regression of pulmonary nodules presenting as epstein-barr virus-related atypical infectious mononucleosis. | pulmonary nodules associated with epstein-barr virus (ebv)-related atypical infectious mononucleosis have rarely been described. | 2016 | 27123664 |
| a novel homozygous mutation in unc13d presenting as epstein-barr-virus-associated lymphoproliferative disease at 9 years of age. | 2016 | 27123661 | |
| detection of epstein-barr virus in synovial fluid of rheumatoid arthritis patients. | rheumatoid arthritis (ra) is one of the most common chronic inflammatory disorders. genes and environmental factors contribute to ra. epstein-barr virus (ebv) has been considered as one the ra pathogeneses. the aim of this study was to detect of the ebv genome in patients with ra. | 2016 | 27123228 |
| age and cellular composition influence overall survival in a collective of non-immunocompromised patients with ebv-positive diffuse large b-cell lymphoma from a german lymphoma center. | we investigated 41 diffuse large b-cell lymphomas (dlbcl) diagnosed at one center harboring ≥50% of latently epstein-barr virus (ebv)-infected neoplastic cells occurring in 34 patients aged ≥50 years and in 7 patients younger than 50 years in the absence of any known immunodeficiency for the expression patterns of ebv latent and immediate-early proteins, for the differentiation stage of the neoplastic cells, the presence of cytogenetic alterations and a possible co-infection with the human herpe ... | 2016 | 27122390 |
| korean perspectives of nasopharynx cancer management. | though korea is located in non-endemic region of epstein-barr virus (ebv) infection and the incidence rate of nasopharynx cancer (npca) is very low, some clinical and histologic characteristics are similar to those in ebv endemic regions. korean radiation oncology group (krog) established a database of npca patients and a few informative studies were performed, which mostly have conformed to those from the previously reports by others. large variation in intensity modulated rt (imrt) detail was ... | 2016 | 27121888 |
| therapeutic vaccination strategies to treat nasopharyngeal carcinoma. | epstein-barr virus (ebv) infects most people worldwide. ebv has oncogenic potential and is strongly associated with several lymphomas and carcinomas, including nasopharyngeal carcinoma (npc), that together total 200,000 cases of cancer each year. all ebv-associated cancers express viral proteins that allow highly selective immunotherapeutic targeting of the malignant cells. a number of therapeutic ebv vaccines have been tested in clinical trials with evidence of immune boosting and clinical resp ... | 2016 | 27121883 |
| immunotherapy for nasopharyngeal cancer-a review. | nasopharyngeal carcinoma (npc) is associated with the epstein-barr virus (ebv) and characterized by peritumoral immune infiltrate. advanced npc has high lethality. immunotherapy directed against ebv antigen targets has been previously explored in clinical trials, and is likely to be validated as an important target in npc as randomized data emerges in the future. cancer vaccines and adoptive t cell therapy have been explored in the clinic, with the latter showing the greatest success. recent adv ... | 2016 | 27121882 |
| advances in systemic treatment for nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is a unique disease endemic in asia. it is etiologically linked to the epstein-barr virus and is both radio- and chemo-sensitive. while radiotherapy (rt) remains the primary treatment modality with high cure rates for early stage disease, systemic treatment forms an important integral component in the treatment of npc, both in the non-metastatic as well as palliative setting. presently, standard therapy in locally advanced npc comprises conventional cytotoxic chemo ... | 2016 | 27121881 |
| clinical trials in nasopharyngeal carcinoma-past, present and future. | nasopharyngeal carcinoma (npc) has an age-adjusted incidence for both sexes with greater frequency in some endemic regions, especially the southern china. genetic, ethnic, environmental factors and epstein-barr virus (ebv) infection might take part in the cause of the disease. based on the understanding and research progresses, we have had a further step among the diagnosis and prognosis of the disease. meanwhile, a numerous clinical trials aiming to pick out the most suitable therapeutic choice ... | 2016 | 27121880 |
| clinical utility of circulating epstein-barr virus dna analysis for the management of nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is one of the commonest cancers in southern china. the carcinogenesis is closely associated with epstein-barr virus (ebv) infection. in endemic regions with high incidence of npc, ebv genome can be detected in virtually all npc tumor tissues. over the last decade, circulating cell-free ebv dna has been developed as a tumor marker for npc. plasma ebv dna analysis using real-time pcr has been shown to be useful for early detection, prognostication and monitoring of t ... | 2016 | 27121878 |
| micrornas in nasopharyngeal carcinoma. | it is becoming increasingly evident that aberrantly expressed micrornas (mirnas) are responsible for a number of disease processes, including cancer initiation and progression. mirnas have been implicated as key players in numerous neoplasms, including nasopharyngeal carcinoma (npc). functionally, deregulation of mirnas that act either as tumour suppressors or oncogenes results in numerous cancer-associated phenomena, including changes in proliferation, migration, and cell survival. furthermore, ... | 2016 | 27121877 |
| genetic and epigenetic landscape of nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is a unique epithelial malignancy that shows a remarkable geographical and ethic distribution. multiple factors including predisposing genetic factors, environmental carcinogens, and epstein-barr virus (ebv) infection contribute to the accumulation of genetic and epigenetic alterations leading to npc development. emerging technologies now allow us to detailedly characterize and understand cancer genomes. genome-wide studies show that typically npc tumors are charac ... | 2016 | 27121876 |
| genetic susceptibility to the endemic form of npc. | nasopharyngeal carcinoma (npc) is a malignancy with remarkably high prevalence in east asia. lines of evidence have suggested the involvement of genetic lesions in the etiology of npc, together with the contributions of epstein-barr virus infection and environmental exposures. linkage and association studies, either based on candidate genes or genome-wide levels, have been conducted to dissect the genetic variants that contribute to npc risk. this review summarizes the current findings of geneti ... | 2016 | 27121875 |
| the correlation between the virus- and brain antigen-specific b cell response in the blood of patients with multiple sclerosis. | there is a largely divergent body of literature regarding the relationship between epstein-barr virus (ebv) infection and brain inflammation in multiple sclerosis (ms). here, we tested ms patients during relapse (n = 11) and in remission (n = 19) in addition to n = 22 healthy controls to study the correlation between the ebv- and brain-specific b cell response in the blood by enzyme-linked immunospot (elispot) and enzyme-linked immunosorbent assay (elisa). cytomegalovirus (cmv) was used as a con ... | 2016 | 27120609 |
| [current research of the roles of il-35 in tumor progression]. | interleukin(il)-35 is a new member of the interleukin-12 superfamily. since its first report in 2007, il-35 rapidly became a research highlight in the field of immunology. like other il-12 superfamily members, il-35 was a heterodimer which was composed of an α chain p35 and a β chain epstein-barr virus induced gene 3 (ebi3). recent research work revealed two distinct roles of il-35. firstly, il-35 is highly expressed in some kinds of inflammatory diseases and autoimmune diseases and plays import ... | 2016 | 27118652 |
| epidemiology of multiple sclerosis: from risk factors to prevention-an update. | although genetic susceptibility explains the clustering of multiple sclerosis (ms) within families and the sharp decline in risk with increasing genetic distance, it cannot fully explain the geographical variations in ms frequency and the changes in risk that occur with migration, which support the action of strong environmental factors. among these, vitamin d status, obesity in early life, infection with the epstein-barr virus, and cigarette smoking are the most consistent environmental predict ... | 2016 | 27116717 |
| filicinic acid based meroterpenoids with anti-epstein-barr virus activities from hypericum japonicum. | seven filicinic acid-based meroterpenoids (1-7), possessing 6/6/11, 6/6/7/5, or 6/6/10 ring systems, were isolated from hypericum japonicum. all of them have novel skeletons with the incorporation of sesquiterpenoid moieties to an acylated filicinic acid. compounds 2a and 4 exhibited significant efficacy on anti-epstein-barr virus, with ec50 values of 0.57 and 0.49 μm, respectively. furthermore, compounds 2a and 4 were well accommodated to the binding pocket of 2gv9 predicted by the molecular do ... | 2016 | 27116597 |
| head and neck epstein-barr virus mucocutaneous ulcer: case report and literature review. | to report the clinical presentation, treatment, and management outcomes of patients with epstein-barr virus-positive mucocutaneous ulcer (ebvmcu) of the head and neck, which is a newly characterized pathologic entity with aggressive morphology but follows an indolent, self-limiting clinical course. | 2016 | 27113560 |
| antigen nature and complexity influence human antibody light chain usage and specificity. | human antibodies consist of a heavy chain and one of two possible light chains, kappa (κ) or lambda (λ). here we tested how these two possible light chains influence the overall antibody response to polysaccharide and protein antigens by measuring light chain usage in human monoclonal antibodies from antibody secreting cells obtained following vaccination with pneumovax23. remarkably, we found that individuals displayed restricted light chain usage to certain serotypes and that lambda antibodies ... | 2016 | 27113164 |
| [prevalence of multiple sclerosis in the region of murcia]. | multiple sclerosis (ms) is a demyelinating inflammatory disease of the central nervous system with immune-mediated pathogenesis. recent research points to an increase in its prevalence, and a number of studies relate epstein-barr virus (ebv) with its aetiology. | 2016 | 27113063 |
| methylation status and ap1 elements are involved in ebv-mediated mir-155 expression in ebv positive lymphoma cells. | the relationship between epstein barr virus (ebv) and mir-155 is well established. ebv infection induces mir-155 expression, which is expressed at higher levels in ebv latency type iii cells compared to ebv latency type i cells. however, the mechanism by which ebv latency genes activate mir-155 expression is still unclear. here we present data showing that dna methylation regulates mir-155 expression. we also provide evidence that the ap1 signaling pathway is involved in ebv-mediated mir-155 act ... | 2016 | 27110708 |
| a gammaherpesvirus noncoding rna is essential for hematogenous dissemination and establishment of peripheral latency. | recent intense investigations have uncovered important functions for a diverse array of novel noncoding rna (ncrna) species, including micrornas (mirnas) and long noncoding rnas. not surprisingly, viruses from multiple families have evolved to encode their own regulatory rnas; however, the specific in vivo functions of these ncrnas are largely unknown. the human gammaherpesviruses epstein-barr virus (ebv) and kaposi's sarcoma-associated herpesvirus (kshv) are highly ubiquitous pathogens that are ... | 2016 | 27110595 |
| impaired cytokine responses to epstein-barr virus antigens in systemic lupus erythematosus patients. | we analyzed cytokine responses against latent and lytic epstein-barr virus (ebv) antigens in systemic lupus erythematosus (sle) patients and healthy controls (hcs) to obtain an overview of the distinctive immune regulatory response in sle patients and to expand the previously determined impaired ebv-directed t-cell response. the concentrations of 14 cytokines (il2, il4, il5, il6, il10, il12, il17, il18, il1β, ifnγ, tnfα, tnfβ, tgfβ, and gm-csf) were quantified upon stimulation of whole blood wit ... | 2016 | 27110576 |
| a scheduled program of molecular screening for epstein-barr virus decreases the incidence of post-transplantation lymphoproliferative disease in pediatric liver transplantation. | this is a cohort, retrospective, comparative study of all liver transplant recipients from a single center, from may 1998 to july 2015. patients were divided into two groups according to the type of epstein-barr viral load monitoring. for group i (1998-2007), polymerase chain reaction (pcr) was not available or it was only qualitative with limited access. for group ii (2008-2015), we used periodically scheduled quantitative pcr in plasma and leukocytes, with aggressive tapering of immunosuppress ... | 2016 | 27110023 |
| post-transplantation infections in bolivia. | over 26 years, we found 46 infectious episodes in 350 kidney transplant recipients. fifteen were urinary tract infections, recurrent in 4 patients. there were 8 cytomegalovirus infections, three of them fatal when intravenous (iv) ganciclovir was not available. seven patients had a reactivation of tuberculosis (tb) in the pleura, cervical spine, lumbar spine, knee, ankle, skin and peritoneum, respectively, and were all resolved satisfactorily with conventional anti-tb therapy. three patients tra ... | 2016 | 27110022 |
| viral infections associated with oral cancers and diseases in the context of hiv: a workshop report. | human herpesviruses (hhvs) and human papillomavirus (hpv) are common in the general population and, in immunocompetent people, are mostly carried asymptomatically. however, once an individual becomes immunocompromised by age, illness or hiv infection these dormant viruses can manifest and produce disease. in hiv-positive patients, there is an increased risk of disease caused by hhvs and hpv infections and cancers caused by the oncoviruses epstein-barr virus, hhv-8 and hpv. this workshop examined ... | 2016 | 27109286 |
| hairy leukoplakia; lessons learned: 30-plus years. | well into the fourth decade of the hiv/aids pandemic, we can look back on the early years, the initial discoveries, and the broad sweep of the progress of our understanding of the nature, causes, and significance of the oral lesions seen in those infected with the virus. prominent among these is oral hairy leukoplakia (hl), a previously unknown lesion of the mouth associated with epstein-barr virus (ebv) and initially seen only in people with aids, in the then-recognized risk groups, or those sh ... | 2016 | 27109280 |
| induction chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in stage iii-ivb nasopharyngeal carcinoma patients with epstein-barr virus dna ≥4000 copies/ml: a matched study. | the effects of induction chemotherapy (ic) followed by concurrent chemoradiotherapy (ccrt) in high-risk (stage iii-ivb with ebv dna≥4000 copies/ml) nasopharyngeal carcinoma (npc) patients are unclear. | 2016 | 27105538 |
| high post-treatment serum levels of soluble programmed cell death ligand 1 predict early relapse and poor prognosis in extranodal nk/t cell lymphoma patients. | the impact of serum levels of soluble programmed cell death ligand 1 (spd-l1) on prognosis in patients with epstein-barr virus-associated malignancies has never been investigated. we prospectively measured pre- and post-treatment serum spd-l1 levels and evaluated their prognostic value in 97 patients with newly diagnosed, early stage extranodal nk/t-cell lymphoma (enktcl) treated with asparaginase-based chemotherapy followed by radiotherapy. for predicting survival outcomes, serum spd-l1 levels ... | 2016 | 27105512 |
| association between hla-a1 and -a2 types and epstein-barr virus status of post-transplant lymphoproliferative disorder. | the susceptibility to epstein-barr virus (ebv)-related post-transplant lymphoproliferative disorder (ptld) may be affected by the human leukocyte antigen (hla) type. we investigated hla-a and hla-b allele frequencies, focusing on hla-a1 and -a2, in a population-based case series of ebv + (n = 60) and ebv- (n = 44) ptld after solid organ transplantation. the proportion of ebv + ptld was highest in hla-a1 homozygotes (100%), lower in carriers of hla-a1/ax (79%), hla-a1/a2 (55%), hla-a2/ax (54%), a ... | 2016 | 27104753 |
| epstein-barr virus-associated gastric carcinoma and specific features of the accompanying immune response. | epstein-barr virus-associated gastric carcinoma (ebvagc) is one of the four subtypes of gastric carcinoma (gc), as defined by the novel classification recently proposed by the cancer genome atlas. ebvagc has several clinicopathological features such as longer survival and higher frequency of lymphoepithelioma-like carcinoma (lelc) and carcinoma with crohn's disease-like lymphoid reaction that distinguish it from ebv-negative gc. the intensity and pattern of host cellular immune response in gc ha ... | 2016 | 27104020 |
| combinatorial epigenetic deregulation by helicobacter pylori and epstein-barr virus infections in gastric tumourigenesis. | epigenetic mechanisms, including dna methylation, histone modifications, chromatin remodelling and micrornas, convert environmental signals to transcriptional outputs but are commonly hijacked by pathogenic microorganisms. recent advances in cancer epigenomics have shed new light on the importance of epigenetic deregulation in helicobacter pylori- and epstein-barr virus (ebv)-driven gastric tumourigenesis. moreover, it is becoming apparent that epigenetic mechanisms interact through crosstalk an ... | 2016 | 27102722 |
| both high and low levels of cellular epstein-barr virus dna in blood identify failure after hematologic stem cell transplantation in conjunction with acute gvhd and type of conditioning. | the level of epstein-barr virus dna in blood has proven to be a biomarker with some predictive value in allogeneic hematopoietic stem cell transplantation patients (hsct). we evaluated the impact of ebv load on survival of 51 patients (32m/19f, median age: 32 years, from < 1 to 68 years old), who had received hsct for different types of malignancies (49 cases) or non-malignancies (2 cases). the overall survival [1]was compared between patients with extreme and moderate cell bound ebv dna levels. ... | 2016 | 27102298 |
| pure lymphoepithelioma-like carcinoma originating from the urinary bladder. | lymphoepithelioma-like carcinoma of the urinary bladder (lelcb) is a rare variant of infiltrating urothelial carcinoma. we report a case of lelcb in a 43-year-old man. ultrasonography and cystoscopy revealed two bladder tumors, one on the left side of the trigone and the other on the right side of the trigone. transurethral resection of the bladder tumors was performed and pathological analysis revealed undifferentiated carcinoma. we therefore performed radical cystectomy and urinary diversion. ... | 2017 | 27099604 |
| epstein-barr virus-associated iris smooth muscle tumor with epithelioid morphology in aids patients: a case report. | report of an acquired immunodeficiency syndrome (aids) patient with epstein-barr virus (ebv)-associated iris smooth muscle tumor. | 2016 | 27099533 |
| [adrenalitis]. | inflammation of the adrenal glands is caused by autoimmunopathies or infections and can induce adrenal insufficiency. autoimmune lymphocytic adrenalitis is often combined with other autoimmune diseases and the most frequent cause of addison's disease; however, it only becomes clinically apparent when more than 90 % of the adrenal cortex has been destroyed. histological features are characterized by lymphoplasmacytic inflammation leading to an increased destruction of adrenocortical tissue but le ... | 2016 | 27099224 |
| early t cell recognition of b cells following epstein-barr virus infection: identifying potential targets for prophylactic vaccination. | epstein-barr virus, a b-lymphotropic herpesvirus, is the cause of infectious mononucleosis, has strong aetiologic links with several malignancies and has been implicated in certain autoimmune diseases. efforts to develop a prophylactic vaccine to prevent or reduce ebv-associated disease have, to date, focused on the induction of neutralising antibody responses. however, such vaccines might be further improved by inducing t cell responses capable of recognising and killing recently-infected b cel ... | 2016 | 27096949 |
| prevalence and risk factors for oral dna tumor viruses in hiv-infected youth. | human papillomavirus (hpv), epstein-barr virus (ebv), and kaposi sarcoma-associated herpes virus (kshv) may promote oral cancers, especially among immunosuppressed individuals. the aims of this study were to examine whether demographic characteristics, medical history, sexual behaviors, substance use, cd4+ t-cell count, hiv viral load, and hpv vaccination were associated with hpv, ebv, and kshv infection and viral load. multivariable modeling using logistic or linear regression examined associat ... | 2016 | 27096166 |
| structural and mechanistic insights into the tropism of epstein-barr virus. | epstein-barr virus (ebv) is the prototypical γ-herpesvirus and an obligate human pathogen that infects mainly epithelial cells and b cells, which can result in malignancies. ebv infects these target cells by fusing with the viral and cellular lipid bilayer membranes using multiple viral factors and host receptor(s) thus exhibiting a unique complexity in its entry machinery. to enter epithelial cells, ebv requires minimally the conserved core fusion machinery comprised of the glycoproteins gh/gl ... | 2016 | 27094060 |
| ebv-positive diffuse large b-cell lymphoma of the elderly: 2016 update on diagnosis, risk-stratification, and management. | epstein-barr virus (ebv)-positive diffuse large b-cell lymphoma (dlbcl) of the elderly is a provisional entity included in the 2008 who classification of lymphoid neoplasms. it is a disease typically seen in the elderly and thought to be associated with chronic ebv infection and severe immunosuppression with a component of immunosenescence. recent research, however, has suggested that ebv-positive dlbcl can be seen in younger, immunocompetent patients. the diagnosis of ebv-positive dlbcl of the ... | 2016 | 27093913 |
| rapid and combined detection of mycoplasma pneumoniae, epstein-barr virus and human cytomegalovirus using allglo quadruplex quantitative pcr. | acute respiratory infections (aris) cause substantial morbidity and mortality worldwide. the causes of ari are dynamic, and co-infections of mycoplasma pneumoniae, epstein-barr virus and human cytomegalovirus are recently developed causes of ari. here, we established a quadruplex quantitative pcr (qpcr) method to rapidly identify and simultaneously detect a single infection or co-infection of these three pathogens and an internal control in a single tube using allglo probes. the analysis demonst ... | 2016 | 27093597 |
| ebv-associated peripheral t-cell lymphoma of gastrointestinal tract presented with widespread chronic inflammation: a case report. | we report a case of epstein-barr virus (ebv)-associated t-cell lymphoma of gastrointestinal (gi) tract from a 70-year-old white woman who initially presented with a widespread gi inflammation and gastric obstruction. initial biopsies of the gi tract showed severe chronic inflammation in the esophagus, stomach, and the small intestine. celiac disease and inflammatory bowel disease were ruled out. the patient was treated with partial gastrectomy. histology showed gastric wall thickening with ebv-p ... | 2017 | 27093448 |
| epstein-barr virus glycoprotein gh/gl antibodies complement iga-viral capsid antigen for diagnosis of nasopharyngeal carcinoma. | to determine whether measuring antibodies against epstein-barr virus (ebv) glycoprotein gh/gl in serum could improve diagnostic accuracy in nasopharyngeal carcinoma (npc) cases, gh/gl expressed in a recombinant baculovirus system was used in an enzyme-linked immunosorbent assay (elisa) to detect antibodies in two independent cohorts. binary logistic regression analyses were performed using results from a training cohort (n = 406) to establish diagnostic mathematical models, which were validated ... | 2016 | 27093005 |
| role of ebna-3 family proteins in ebv associated b-cell lymphomagenesis. | epstein-barr virus (ebv) is highly ubiquitous in human population and establishes a lifelong asymptomatic infection within the infected host unless the immune system is compromised. following initial infection in the oropharyngeal epithelial cells, ebv primarily infects naive b-lymphocytes and develops a number of b-cell lymphomas particularly in immune-deficient individuals. in vitro, ebv can also infect and subsequently transform quiescent b-lymphocytes into continuously proliferating lymphobl ... | 2016 | 27092119 |
| impact of donor epstein-barr virus serostatus on the incidence of graft-versus-host disease in patients with acute leukemia after hematopoietic stem-cell transplantation: a study from the acute leukemia and infectious diseases working parties of the european society for blood and marrow transplantation. | we investigated the effect of epstein-barr virus (ebv) serostatus on the overall outcome of allogeneic hematopoietic stem-cell transplantation (allo-hsct). | 2016 | 27091716 |
| epstein-barr virus and b cells in the pathogenesis of graft-versus-host disease after allogeneic hematopoietic stem-cell transplantation. | 2016 | 27091710 | |
| epstein-barr virus latency type and spontaneous reactivation predict lytic induction levels. | the human epstein-barr virus (ebv) evades the immune system by entering a transcriptionally latent phase in b cells. ebv in tumor cells expresses distinct patterns of genes referred to as latency types. viruses in tumor cells also display varying levels of lytic transcription resulting from spontaneous reactivation out of latency. we measured this dynamic range of lytic transcription with rna deep sequencing and observed no correlation with ebv latency types among genetically different viruses, ... | 2016 | 27091426 |
| l-asparaginase-based regimens followed by allogeneic hematopoietic stem cell transplantation improve outcomes in aggressive natural killer cell leukemia. | aggressive nature killer cell leukemia (ankl) is a mature nk-t cell lymphoma with worse prognosis, but optimal treatment is unclear. therefore, we analyzed the efficacy of l-asparaginase-based regimens for ankl patients. twenty-one patients who received dexamethasone, methotrexate, ifosfamide, l-asparaginase, and etoposide (smile) or etoposide, ifosfamide, dexamethasone, and l-asparaginase (vidl) chemotherapy at samsung medical center were selected. the overall response rate for all patients was ... | 2016 | 27091029 |
| acute acalculous cholecystitis in a lebanese girl with primary epstein-barr viral infection. | acute acalculous cholecystitis (aac) constitutes 5-10% of all cases of cholecystitis in adults, and is even less common in children. the recent literature has described an association between primary epstein-barr virus (ebv) infection and aac, however, it still remains an uncommon presentation of the infection. most authors advise that the management of aac in patients with primary ebv infection should be supportive, since the use of antibiotics does not seem to alter the severity or prognosis o ... | 2016 | 27090538 |
| spectrum of viral pathogens in blood of malaria-free ill travelers returning to canada. | malaria is the most common specific cause of fever in returning travelers, but many other vectorborne infections and viral infections are emerging and increasingly encountered by travelers. we documented common and emerging viral pathogens in malaria-negative specimens from ill travelers returning to canada. anonymized, malaria-negative specimens were examined for various viral pathogens by real-time pcr. samples were positive for herpes simplex viruses 1 or 2 (n = 21, 1.6%), cytomegalovirus (n ... | 0 | 27089008 |
| a nation-wide epidemiological study on the risk of developing second malignancies in patients with different histological subtypes of nasopharyngeal carcinoma. | risk assessment of second head/neck and epstein barr virus (ebv)-related malignancies in patients with different nasopharyngeal carcinoma (npc) subtypes. | 2016 | 27086485 |
| identification of gla/se as an effective adjuvant for the induction of robust humoral and cell-mediated immune responses to ebv-gp350 in mice and rabbits. | childhood infection with epstein-barr virus (ebv) is often asymptomatic and may result in mild flu-like symptoms, but exposure during adolescence and young adulthood can lead to acute infectious mononucleosis (aim) with a pathology characterized by swollen lymph nodes, sore throat, and severe fatigue lasting weeks or months. a vaccine targeting the envelope glycoprotein gp350 adjuvanted with aluminum hydroxide complexed with the tlr4 agonist monophosphoryl lipid a (mpla) achieved a 78% reduction ... | 2016 | 27085175 |
| humoral markers of active epstein-barr virus infection associate with anti-extractable nuclear antigen autoantibodies and plasma galectin-3 binding protein in systemic lupus erythematosus. | we investigated if signs of active epstein-barr virus and cytomegalovirus infections associate with certain autoantibodies and a marker of type i interferon activity in patients with systemic lupus erythematosus. igm and igg plasma levels against epstein-barr virus early antigen diffuse and cytomegalovirus pp52 were applied as humoral markers of ongoing/recently active epstein-barr virus and cytomegalovirus infections, respectively. plasma galectin-3 binding protein served as a surrogate marker ... | 2016 | 27084029 |
| specific expression and methylation of slit1, slit2, slit3, and mir-218 in gastric cancer subtypes. | slit has been suggested as a key regulator of cancer development and a promising therapeutic target for cancer treatment. herein, we analyzed expression and methylation of slit1/slit2/slit3 in 11 gastric cancer cell lines, 96 paired gastric tumors and adjacent normal gastric tissues, and 250 gastric cancers provided by the cancer genome atlas. methylation of slit1/slit2/slit3 was found both in early gastric cancers, and in advanced gastric cancers. even normal gastric tissue showed increased met ... | 2016 | 27082735 |
| co-prevalence of epstein-barr virus and high-risk human papillomaviruses in syrian women with breast cancer. | abstrat we recently performed 2 studies viewing the presence of epstein-barr virus (ebv) and high-risk human papillomaviruses (hpvs) types 16, 18, 31, 33 and 35 in human breast cancer in the syrian population. herein, we report that ebv and high-risk hpvs are co-present in breast cancer in syrian women. therefore, and based on our previous studies and present data, we reveal that 35 (32%) of 108 cancer samples are positive for both ebv and high-risk hpvs and their co-presence is associated with ... | 2016 | 27082145 |
| neurosurgery and human immunodeficiency virus in the era of combination antiretroviral therapy: a review. | human immunodeficiency virus (hiv) is a global health problem. it renders the central nervous system susceptible to infectious and noninfectious diseases. hiv-positive individuals may present to neurosurgical services with brain lesions of unknown etiology. the differential diagnosis in these cases is broad, including opportunistic infections and malignancies, and investigation should be tailored accordingly. opportunistic infections of the central nervous system can be complicated by hydrocepha ... | 2017 | 27081898 |
| recombinase activating gene 1 deficiencies without omenn syndrome may also present with eosinophilia and bone marrow fibrosis. | severe combined immunodeficiency (scid) syndromes are a heterogenous group of diseases characterized by impairment in both cellular and humoral immunity with a range of genetic disorders. complete recombinase activating gene (rag) deficiency is associated with classical t(-)b(-)nk(+) scid which is the most common phenotype of turkish scid patients. there is a broad spectrum of hypomorfic rag mutations including omenn syndrome, leaky or atypical scid with expansion of γδ t cells, autoimmunity and ... | 2016 | 27081423 |
| litsea species as potential antiviral plant sources. | litsea verticillata hance (lauraceae), a chinese medicine used to treat swelling caused by injury or by snake bites, was the first plant identified by our national institutes of health (nih)-funded international cooperative biodiversity group (icbg) project to exhibit anti-hiv activities. from this plant, we discovered a class of 8 novel litseane compounds, prototypic sesquiterpenes, all of which demonstrated anti-hiv activities. in subsequent studies, 26 additional compounds of different struct ... | 2016 | 27080941 |
| synchronous biphenotypic richter syndrome with epstein-barr virus-positive nodal classical hodgkin lymphoma and bone marrow diffuse large b-cell lymphoma. | 2016 | 27079556 | |
| [oral plasmablastic lymphoma in a human immunodeficiency virus positive child: a case report]. | plasmablastic lymphoma is a rare and aggressive subtype of diffuse large b cell non-hodgkin lymphoma, originally described in the oral cavity of male adults with acquired immune deficiency syndrome. it is composed of neoplastic ceils which resemble immunoblasts but present immunophenotype distinctive of plasma cell and epstein-barr virus latent infection. in children, it is an even rarer disease. we present a case of oral plasmablastic lymphoma in a vertically transmitted human immunodeficiency ... | 2016 | 27079412 |
| cholecystitis and nephrotic syndrome complicating epstein-barr virus primary infection. | epstein-barr virus (ebv) infection results in a spectrum of clinical manifestations. the host immune response to ebv plays a key role in the extent and degree of clinical features, which in children under 4 years of age are usually mild, non-specific and self-limiting. a 2-year-old boy in whom no known immune disorder could be found presented with acute acalculous cholecystitis, renal dysfunction with massive proteinuria, ascites, pleural effusion, minimal peripheral oedema and a severe systemic ... | 2017 | 27077634 |
| the epstein-barr virus glycoprotein gp150 forms an immune-evasive glycan shield at the surface of infected cells. | cell-mediated immunity plays a key role in host control of viral infection. this is exemplified by life-threatening reactivations of e.g. herpesviruses in individuals with impaired t-cell and/or inkt cell responses. to allow lifelong persistence and virus production in the face of primed immunity, herpesviruses exploit immune evasion strategies. these include a reduction in viral antigen expression during latency and a number of escape mechanisms that target antigen presentation pathways. given ... | 2016 | 27077376 |
| circulating ebv dna, globulin and nodal size predict distant metastasis after intensity-modulated radiotherapy in stage ii nasopharyngeal carcinoma. | the optimal treatment for early-stage nasopharyngeal carcinoma (npc) remains controversial. identification of prognostic factors for metastasis and tumor progression is urgently required to improve clinical decision-making for patients with american joint committee on cancer (ajcc) 2009 stage ii npc from the endemic area. | 2016 | 27076847 |
| multicenter evaluation of whole-blood epstein-barr viral load standardization using the who international standard. | the first who international standard for epstein-barr virus (ebv) (who ebv standard) for nucleic acid amplification technology (nat)-based assays was commercialized in january 2012 by the national institute for biological standards and control. in the study reported here, we compared whole-blood ebv dna load (edl) results from 12 french laboratories for seven samples (quality controls for molecular diagnostics 2013 proficiency panel) in order to determine whether expression in international unit ... | 2016 | 27076661 |
| acute generalized exanthematous pustulosis associated with primary epstein-barr virus infection. | 2015 | 27075126 | |
| lymphoepithelioma-like gastric carcinoma in a patient with rectal laterally spreading tumor: a case report. | lymphoepithelioma-like gastric carcinoma (lelgc) is a rare neoplasm of the stomach that accounts for 1-4% of all gastric cancer cases. it is characterized by the presence of a lymphoid stroma with cells arranged primarily in micro alveolar, thin trabecular and primitive tubular patterns or isolated cells. in the present study, the case of a 50-year-old male patient with lelgc and rectal laterally spreading tumor is presented. following endoscopic submucosal dissection, a diagnosis of carcinoma w ... | 2016 | 27073504 |
| glypican-4 gene polymorphism (rs1048369) and susceptibility to epstein-barr virus-associated and -negative gastric carcinoma. | gastric cancer (gc) is one of the most common malignant tumors in china and single nucleotide polymorphisms (snps) have been found to be highly related to gc carcinogenesis. glypican-4 (gpc4), a member of the heparan sulphate proteoglycan family, plays an important role in the regulation of cell growth and differentiation. however, little is known about polymorphisms of gpc4 gene and their associated susceptibility to gc, especially to epstein-barr virus-associated gc (ebvagc). here we studied t ... | 2016 | 27071854 |
| characterization of the variability of epstein-barr virus genes in nasopharyngeal biopsies: potential predictors for carcinoma progression. | epstein-barr virus (ebv) infection is a significant factor in the pathogenesis of nasopharyngeal carcinoma, especially in the undifferentiated carcinoma of nasopharyngeal type (ucnt, world health organization type iii), which is the dominant histopathological type in high-risk areas. the major ebv oncogene is latent membrane protein 1 (lmp1). lmp1 gene shows variability with different tumorigenic and immunogenic potentials. ebv nuclear antigen 1 (ebna1) regulates progression of ebv-related tumor ... | 2016 | 27071030 |
| acute idiopathic scrotal edema caused by epstein-barr virus. | 2016 | 27071015 | |
| epstein-barr virus ebna-2 polymorphic patterns in nasopharyngeal carcinoma in southern china. | the aim of this study was to characterize the specific epstein-barr virus (ebv) polymorphisms from nasopharyngeal carcinoma (npc) patients and healthy donors in southern china, and to explore the relationship between ebv genotypes and npc. | 2015 | 27070148 |
| viral carcinogenesis beyond malignant transformation: ebv in the progression of human cancers. | cancer progression begins when malignant cells colonize adjacent sites, and it is characterized by increasing tumor heterogeneity, invasion and dissemination of cancer cells. clinically, progression is the most relevant stage in the natural history of cancers. a given virus is usually regarded as oncogenic because of its ability to induce malignant transformation of cells. nonetheless, oncogenic viruses may also be important for the progression of infection-associated cancers. recently this hypo ... | 2016 | 27068530 |
| [molecular subtypes of gastric cancer]. | gastric cancer has been classified based on the pathological characteristics including microscopic configuration and growth pattern. although these classifications have been used in studies investigating prognosis and recurrence pattern, they are not considered for decisions regarding the therapeutic strategy. in the toga study, trastuzumab, an anti-her2 monoclonal antibody, demonstrated clinical efficacy for gastric cancer with her2 overexpression or her2 gene amplification. based on these find ... | 2016 | 27067842 |
| epstein-barr virus-associated lymphoepithelial carcinoma after pediatric liver transplant. | 2016 | 27065464 | |
| cordycepin enhances epstein-barr virus lytic infection and epstein-barr virus-positive tumor treatment efficacy by doxorubicin. | the consistent latent presence of epstein-barr virus (ebv) in tumor cells offers potential for virus-targeted therapies. the switch from the latent form of ebv to the lytic form in tumor cells can lead to tumor cell lysis. in this study, we report that a natural small molecule compound, cordycepin, can induce lytic ebv infection in tumor cells. subsequently, we demonstrate that cordycepin can enhance ebv reactivating capacity and ebv-positive tumor cell killing ability of low dose doxorubicin. t ... | 2016 | 27063964 |
| rta-igg as a biomarker for diagnosis and post treatment prognostic of nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is a common type of head and neck cancer. | 2016 | 27062704 |
| immunotherapeutic approaches for the treatment of childhood, adolescent and young adult non-hodgkin lymphoma. | with the introduction of the anti-cd20 monoclonal antibody rituximab, b-cell non-hodgkin lymphoma was the first malignancy successfully treated with an immunotherapeutic agent. since then, numerous advances have expanded the repertoire of immunotherapeutic agents available for the treatment of a variety of malignancies, including many lymphoma subtypes. these include the introduction of monoclonal antibodies targeting a variety of cell surface proteins, including the successful targeting of immu ... | 2016 | 27062282 |
| clonal deleted latent membrane protein 1 variants of epstein-barr virus are predominant in european extranodal nk/t lymphomas and disappear during successful treatment. | extranodal natural killer/t-cell lymphomas (nk/tl), rare in europe, are epstein-barr virus (ebv) associated lymphomas with poor outcomes. here, we determined the virus type and analyzed the ebv latent membrane protein-1 (lmp1) gene sequence in nk/tl from french patients. six clones of viral lmp1 were sequenced by sanger technology in blood from 13 patients before treatment with an l-asparaginase based regimen and, for 8 of them, throughout the treatment. blood lmp1 sequences from 21 patients wit ... | 2016 | 27061907 |
| detection of epstein-barr virus dnaemia after lung transplantation and its potential relationship with the development of post-transplant complications. | recent studies suggest that epstein-barr virus dnaemia (ebvd) may act as a surrogate marker of post-transplant immunosuppression. this hypothesis has not been tested so far in lung transplant (lt) recipients. | 2016 | 27061510 |
| the bdlf3 gene product of epstein-barr virus, gp150, mediates non-productive binding to heparan sulfate on epithelial cells and only the binding domain of cd21 is required for infection. | the cell surface molecules used by epstein-barr virus (ebv) to attach to epithelial cells are not well-defined, although when cd21, the b cell receptor for ebv is expressed epithelial cell infection increases disproportionately to the increase in virus bound. many herpesviruses use low affinity charge interactions with molecules such as heparan sulfate to attach to cells. we report here that the ebv glycoprotein gp150 binds to heparan sulfate proteoglycans, but that attachment via this glycoprot ... | 2016 | 27061054 |
| herpesvirus infections in hematopoietic stem cell transplant recipients seropositive for human cytomegalovirus before transplantation. | viral infections are a major cause of morbidity and mortality after hematopoietic stem cell transplantation (hsct). the effect of herpesvirus infections in human cytomegalovirus (hcmv)-seropositive (igg-positive/igm-negative) hsct recipients remains poorly understood. the risk factors associated with epstein-barr virus (ebv), hcmv, and human herpes virus type 6 (hhv-6) infections after hsct, both alone and in combination, were investigated in this study. | 2016 | 27057748 |
| itk gene mutation: effect on survival of children with severe hemophagocytic lymphohistiocytosis. | hemophagocytic lymphohistiocytosis (hlh) is characterized by deadly hyperinflammatory syndrome, but data on severe hlh with multi-organ dysfunction in children are scant. the authors report a retrospective study of 8 cases with severe hlh from a pediatric intensive care unit (picu) over a 1-y period and found that epstein barr virus (ebv) -infection was the most common etiology. all patients had genetic analysis, which showed that four patients with ebv -infection had one homozygous mutation, c. ... | 2016 | 27056244 |
| epstein-barr virus and gastric cancer risk: a meta-analysis with meta-regression of case-control studies. | research on how the risk of gastric cancer increases with epstein-barr virus (ebv) infection is lacking. in a systematic review that investigated studies published until september 2014, the authors did not calculate the summary odds ratio (sor) due to heterogeneity across studies. therefore, we include here additional studies published until october 2015 and conduct a meta-analysis with meta-regression that controls for the heterogeneity among studies. | 2016 | 27055546 |
| mosquito vectors and the spread of cancer: an overlooked connection? | mosquitoes (diptera: culicidae) represent a key threat for millions of humans and animals worldwide, vectoring important pathogens and parasites, including malaria, dengue, filariasis, and zika virus. besides mosquito-borne diseases, cancers figure among the leading causes of mortality worldwide. it is expected that annual cancer cases will rise from 14 million in 2012 to 22 million within the next two decades. notably, there are few contrasting evidences of the relationship between cancer and m ... | 2016 | 27053131 |
| ebv-related malignancies, outcomes and novel prevention strategies. | epstein barr virus (ebv) is a common gamma herpes virus with a high prevalence in adults worldwide. infection is mostly latent in affected individuals. ebv has been linked mostly with lymphoid malignancies but its association with epithelial and other non-lymphoid malignancies has also been described. | 2016 | 27052336 |
| a case of lymphomatoid granulomatosis presenting with cutaneous lesions. | 2015 | 27051739 | |
| atypical hydroa vacciniforme mimicking dermatomyositis: a case report in a lebanese girl. | 2015 | 27051685 | |
| a case of exuberant cutaneous lymphomagenesis in the setting of chronic patch mycosis fungoides. | 2015 | 27051679 |