Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| fine specificity of the antibody response to epstein-barr nuclear antigen-2 and other epstein-barr virus proteins in patients with clinically isolated syndrome: a peptide microarray-based case-control study. | we analyzed the fine specificity of antibodies to epstein-barr nuclear antigen-2 (ebna-2) and other epstein-barr virus (ebv) proteins in 29 patients with clinically isolated syndrome (cis, the first clinical manifestation of multiple sclerosis [ms]) and 29 controls with a peptide microarray containing 117 overlapping peptides representing the full-length ebna-2 protein and 71 peptides from 8 further ebv proteins. while ebv peptide antibodies were elevated in cis, suggesting that ebv contributes ... | 2016 | 27397076 |
| [research advances in target genes of epstein-barr virus-encoded micrornas]. | the epstein-barr virus (ebv) is a gamma herpes virus associated with several types of malignancies. the ebv encodes viral micrornas (mirnas) that can target genes within cells. the ebv participates in signal transduction as well as the proliferation and differentiation of cells. how the target genes and functions of ebv-encoded mirnas contribute to the pathogenesis of ebv is an important research topic. some target genes have been validated since ebv-encoded mirnas were discovered and, in this a ... | 2016 | 27396169 |
| phenylethylchromones with in vitro antitumor promoting activity from aquilaria filaria. | a new chromone, 2-(2-hydroxy-2-phenylethyl)chromone (1), was isolated together with ten known phenylethyl chromones from meoh extracts of agarwood (aquilaria filaria). the selected compounds were evaluated in an antiproliferative assay against five human tumor cell lines, including a multidrug-resistant cell line. they were also tested for antitumor promoting activity, as mediated by 12-o-tetradecanoylphorbol-13-acetate-induced activation of the epstein-barr virus early antigen in raji cells. am ... | 2017 | 27392244 |
| facial manifestations of epstein-barr virus-related lymphoproliferative disease in childhood acute lymphoblastic leukemia in remission: two atypical presentations. | epstein-barr virus-related lymphoproliferative disease (ebv-lpd) rarely occurs in patients with acute lymphoblastic leukemia (all), who have not received hematopoietic transplantation. we describe ebv-lpd manifesting as facial lesions in two children with all in remission. one patient was a 16-year-old male with t-cell all with an ebv-positive angiocentric polymorphous lip lesion presenting as right-sided facial swelling. the other patient was a 12-year-old male with b-cell all with an ebv-posit ... | 2016 | 27392033 |
| expression of cdx2 and thyroid transcription factor-1 in oropharyngeal undifferentiated carcinomas: a potential diagnostic pitfall. | oropharyngeal undifferentiated carcinomas are rare and most are human papillomavirus related. morphologically, they overlap with undifferentiated carcinomas from other organ sites, including the nasopharynx, lung, and gastrointestinal tract. most have lymph node metastases at presentation and, especially when initially encountered in a lymph node, immunostains may be performed to determine the most likely primary site. we recently reviewed a case in consultation that strongly and diffusely expre ... | 2016 | 27389559 |
| conjugating prussian blue nanoparticles onto antigen-specific t cells as a combined nanoimmunotherapy. | to engineer a novel nanoimmunotherapy comprising prussian blue nanoparticles (pbnps) conjugated to antigen-specific cytotoxic t lymphocytes (ctl), which leverages pbnps for their photothermal therapy (ptt) capabilities and epstein-barr virus (ebv) antigen-specific ctl for their ability to traffic to and destroy ebv antigen-expressing target cells. | 2016 | 27389189 |
| a child's hla-drb1 genotype increases maternal risk of systemic lupus erythematosus. | systemic lupus erythematosus (sle) disproportionately affects women of reproductive age. during pregnancy, women are exposed to various sources of fetal material possibly constituting a significant immunologic exposure relevant to the development of sle. the objective of this study was to investigate whether having any children who carry drb1 alleles associated with sle increase the risk of maternal sle. this case-control study is based on the university of california, san francisco mother-child ... | 2016 | 27388144 |
| post-transcriptional regulation of klf4 by high-risk human papillomaviruses is necessary for the differentiation-dependent viral life cycle. | human papillomaviruses (hpvs) are epithelial tropic viruses that link their productive life cycles to the differentiation of infected host keratinocytes. a subset of the over 200 hpv types, referred to as high-risk, are the causative agents of most anogenital malignancies. hpvs infect cells in the basal layer, but restrict viral genome amplification, late gene expression, and capsid assembly to highly differentiated cells that are active in the cell cycle. in this study, we demonstrate that hpv ... | 2016 | 27386862 |
| clinicopathological features of low-grade thyroid-like nasopharyngeal papillary adenocarcinoma. | primary low-grade thyroid-like papillary adenocarcinomas are extremely rare neoplasms that generally originate in the nasopharynx. here, we describe a novel case of a 15-year-old chinese girl who was diagnosed with low-grade thyroid-like papillary adenocarcinoma, including a brief review of the literature to reveal the clinicopathological features of low-grade thyroid-like nasopharyngeal papillary adenocarcinoma. | 2017 | 27384157 |
| serum baff levels, methypredsinolone therapy, epstein-barr virus and mycobacterium avium subsp. paratuberculosis infection in multiple sclerosis patients. | elevated b lymphocyte activating factor baff levels have been reported in multiple sclerosis (ms) patients; moreover, disease-modifying treatments (dmt) have shown to influence blood baff levels in ms patients, although the significance of these changes is still controversial. in addition, baff levels were reported increased during infectious diseases. in our study, we wanted to investigate on the serum baff concentrations correlated to the antibody response against mycobacterium avium subspecie ... | 2016 | 27383531 |
| esophageal and gastric ulceration due to synchronous herpes simplex virus, cytomegalovirus and epstein-barr virus infection. | 2016 | 27382954 | |
| targeting the ca(2+) sensor stim1 by exosomal transfer of ebv-mir-bart13-3p is associated with sjögren's syndrome. | primary sjögren's syndrome (pss) is a systemic autoimmune disease that is associated with inflammation and dysfunction of salivary and lacrimal glands. the molecular mechanism(s) underlying this exocrinopathy is not known, although the syndrome has been associated with viruses, such as the epstein barr virus (ebv). we report herein that an ebv-specific microrna (ebv-mir-bart13-3p) is significantly elevated in salivary glands (sgs) of pss patients and we show that it targets stromal interacting m ... | 2016 | 27381477 |
| human oncogenic herpesvirus and post-translational modifications - phosphorylation and sumoylation. | pathogens, especially viruses, evolve abilities to utilize cellular machineries to facilitate their survival and propagation. post-translational modifications (ptms), especially phosphorylation and sumoylation, that reversibly modulate the function and interactions of target proteins are among the most important features in cell signaling pathways. ptm-dependent events also serve as one of the favorite targets for viruses. among the seven unambiguous human oncogenic viruses, hepatitis b virus (h ... | 2016 | 27379086 |
| changing patterns in the epstein-barr virus (ebv)and hodgkin lymphoma association in tunisia. | we compared the features of the epstein-barr virus (ebv) and hodgkin lymphoma (hl) association in tunisia in two periods of time, 1991-2001 (111 cases) and 2002-2012 (122 cases). the investigation of the ebv status by eber in situ hybridization showed a significant decrease in the prevalence of ebv-positive hl from 69.3 % for the period 1991-2001 to 40.1 % for the 2002-2012 period (p = 0.00001). ebv positivity has decreased in all age groups but was more pronounced among young patients, in the 1 ... | 2016 | 27378019 |
| classical hodgkin lymphoma with positive epstein-barr virus status is associated with more foxp3 regulatory t cells. | background classical hodgkin lymphoma (chl) is characterized by sparse malignant hodgkin and reed-sternberg cells dispersed in an inflammatory microenvironment. immune evasion of malignant cells is partially due to the existence of a subpopulation of immunosuppressive regulatory t cells (treg). the aim of this study was to analyze t cell composition in chl with special emphasis on treg in regard to epstein-barr virus (ebv) status, subtype, and patient age. material and methods the study included ... | 2016 | 27377121 |
| viral noncoding rnas in cancer biology. | over 12 % of all human cancers are caused by oncoviruses, primarily including epstein-barr virus (ebv), high-risk human papillomaviruses (hpvs), hepatitis b and c viruses (hbv and hcv, respectively), and kaposi's sarcoma herpesvirus (kshv). in addition to viral oncoproteins, a variety of noncoding rnas (ncrnas) produced by oncoviruses have been recognized as important cofactors that contribute to the oncogenic events. in this chapter, we will focus on the recent understanding of the long and sho ... | 2016 | 27376743 |
| herpesvirus late gene expression: a viral-specific pre-initiation complex is key. | during their productive cycle, herpesviruses exhibit a strictly regulated temporal cascade of gene expression that can be divided into three general stages: immediate-early (ie), early (e), and late (l). this expression program is the result of a complex interplay between viral and cellular factors at both the transcriptional and post-transcriptional levels, as well as structural differences within the promoter architecture for each of the three gene classes. since the cellular enzyme rna polyme ... | 2016 | 27375590 |
| late persistent positive ebv viral load and risk of solid cancer in kidney transplant patients. | recent studies reported that posttransplant epstein-barr virus (ebv) replication is frequent and indicates overimmunosuppression. we hypothesized that long-term ebv replication may identify overimmunosuppressed patients at higher risk of cancer. | 2016 | 27367471 |
| prognostic significance of signal transducer and activator of transcription 5 and 5b expression in epstein-barr virus-positive patients with chronic lymphocytic leukemia. | signal transducer and activator of transcription (stat) proteins have been intensively studied in hematologic malignancies, and the efficacy of agents against stats in lymphomas is already under research. we investigated the expression of total stat5 and stat5b in peripheral blood samples of patients with chronic lymphocytic leukemia (cll) in correlation with the presence of epstein-barr virus (ebv) and its major oncoprotein (latent membrane protein 1, lmp1). the ebv load was measured in the per ... | 2016 | 27367207 |
| evaluation of the risk of lymphomagenesis in xenografts by the pcr-based detection of ebv bamhi w region in patient cancer specimens. | establishment of patient-derived tumor xenografts (pdxs) is hampered by lymphomagenesis mostly caused by the latently-infected epstein-barr virus (ebv) contained in patient cancer tissues. however, the character of patient tissues that result in lymphomagenesis after xenotransplantation is not elucidated. in this study, we analyzed the patient colorectal cancer (crc) tissues and the pdxs established by their xenotransplantation. we found that 2 of 9 (22%) pdx tumors were ebv-associated human dif ... | 2016 | 27367028 |
| management of epstein-barr virus infections and post-transplant lymphoproliferative disorders in patients after allogeneic hematopoietic stem cell transplantation: sixth european conference on infections in leukemia (ecil-6) guidelines. | epstein-barr virus-related post-transplant lymphoproliferative disorders are recognized as a significant cause of morbidity and mortality in patients undergoing hematopoietic stem cell transplantation. to better define current understanding of post-transplant lymphoproliferative disorders in stem cell transplant patients, and to improve its diagnosis and management, a working group of the sixth european conference on infections in leukemia 2015 reviewed the literature, graded the available quali ... | 2016 | 27365460 |
| virus reactivations after autologous hematopoietic stem cell transplantation detected by multiplex pcr assay. | several studies have indicated that viral reactivations following allogeneic hematopoietic stem cell transplantation (allo-hsct) are frequent, but viral reactivations after autologous hsct (auto-hsct) have not been investigated in detail. we performed multiplex polymerase chain reaction (pcr) assay to examine multiple viral reactivations simultaneously in 24 patients undergoing auto-hsct between september 2010 and december 2012. weekly whole blood samples were collected from pre- to 42 days post ... | 2017 | 27364410 |
| recurrence of tubulointerstitial nephritis without uveitis, in a patient with previous tubulointerstitial nephritis and uveitis syndrome after transplant. | we report a case of recurrent tubulointerstitial nephritis without uveitis in a patient with previous tubulointerstitial nephritis and uveitis syndrome after transplant. a 26-year-old male patient who had been diagnosed with tubulointerstitial nephritis and uveitis syndrome at 8 years of age developed end-stage renal failure and subsequently underwent living-donor related renal transplant at 17 years old. the 1st recurrence of tubulointerstitial nephritis and uveitis occurred 36 months after tra ... | 2016 | 27364115 |
| epstein-barr virus-associated smooth muscle tumor. | immunodeficient individuals are prone to develop a number of opportunistic infections and unique neoplasms. epstein-barr virus-associated smooth muscle tumor is an uncommon neoplasm associated with immunodeficiency. it has been described in patients infected with human immunodeficiency virus, in the posttransplant setting, and in those with congenital immunodeficiency. different anatomic sites can be involved by epstein-barr virus-associated smooth muscle tumor, and even multiple locations can c ... | 2016 | 27362573 |
| crispr/cas9-mediated genome editing of herpesviruses limits productive and latent infections. | herpesviruses infect the majority of the human population and can cause significant morbidity and mortality. herpes simplex virus (hsv) type 1 causes cold sores and herpes simplex keratitis, whereas hsv-2 is responsible for genital herpes. human cytomegalovirus (hcmv) is the most common viral cause of congenital defects and is responsible for serious disease in immuno-compromised individuals. epstein-barr virus (ebv) is associated with infectious mononucleosis and a broad range of malignancies, ... | 2016 | 27362483 |
| splenic infarction associated with acute infectious mononucleosis due to epstein-barr virus infection. | the purpose of this study was to report a case of a previously healthy 20-year-old woman diagnosed with splenic infarction following infectious mononucleosis (im) by epstein-barr virus (ebv) infection and to perform the first systematic review of the clinical characteristics of splenic infarction associated with im. a systematic review was conducted using english, french, and japanese literatures of splenic infarction associated with im due to ebv infection published between 1961 and 2015 in pub ... | 2017 | 27357912 |
| loss of arid1a expression predicts poor survival prognosis in gastric cancer: a systematic meta-analysis from 14 studies. | the chromatin remodeling gene, at-rich interactive domain 1a gene (arid1a), frequently mutates inactively in gastric cancer (gc). however, its prognostic value remains controversial. to address this issue, a comprehensive meta-analysis was performed. studies published until march 2016 were systematically searched. a total of 15 cohorts from 14 literatures involving 3183 patients were subjected to this meta-analysis. the pooled data showed that arid1a expression loss predicted poor overall surviv ... | 2016 | 27354232 |
| response to 5-azacytidine in a patient with tet2-mutated angioimmunoblastic t-cell lymphoma and chronic myelomonocytic leukaemia preceded by an ebv-positive large b-cell lymphoma. | we report the case of a patient with a history of epstein-barr virus-positive large b-cell lymphoma, who relapsed with an angioimmunoblastic t-cell lymphoma (aitl) associated with a chronic myelomonocytic leukaemia (cmml). we performed targeted next-generation sequencing on cmml and aitl dna, which revealed mutations of tet2, dnmt3a, srsf2, nras and idh1, thus confirming that the spectrum of aitl mutations share similarities with myeloid disorders. the frequencies of tet2/dnmt3a and srsf2 varian ... | 2016 | 27353473 |
| three rwandan children with massive splenomegaly and epstein-barr virus-associated lymphoproliferative disorders: case presentations and the literature review. | this report describes 3 rwandan children with massive splenomegaly and pancytopenia who underwent splenectomy. each was diagnosed with epstein-barr virus-associated lymphoproliferative disorder (ebv lpd) based on lymphocyte morphology, lymphocyte immunophenotype, and the results of ebv in situ hybridization studies. the differential diagnosis of splenomegaly, with a special emphasis on the sub-saharan african context, is discussed along with ebv and associated disorders. these cases serve as a c ... | 2016 | 27352192 |
| a fully human igg1 anti-pd-l1 mab in an in vitro assay enhances antigen-specific t-cell responses. | monoclonal antibodies (mabs) that interfere with checkpoint molecules are being investigated for the treatment of infectious diseases and cancer, with the aim of enhancing the function of an impaired immune system. avelumab (msb0010718c) is a fully human igg1 mab targeting programmed death-ligand 1 (pd-l1), which differs from other checkpoint-blocking antibodies in its ability to mediate antibody-dependent cell-mediated cytotoxicity. these studies were conducted to define whether avelumab could ... | 2016 | 27350882 |
| epstein-barr virus dynamics in asymptomatic immunocompetent adults: an intensive 6-month study. | characterizing epstein-barr virus (ebv) dynamics in asymptomatic immunocompetent persons provides a baseline for defining quantitative thresholds associated with ebv disease. studying latent membrane protein (lmp)-1 sequence variation over time could establish the rates of reactivation and superinfection, and also trace transmission. twelve asymptomatic adult subjects were evaluated prospectively nine times over 6 months. ebv serum antibodies were measured by enzyme immunoassay. ebv dna in oral ... | 2016 | 27350880 |
| successful treatment of ileal ulcers caused by immunosuppressants in two organ transplant recipients. | although gastroduodenal ulcers are common in solid organ transplant patients, there are few reports on multiple giant ulcers in the distal ileum and ileocecal valve caused by immunosuppressants herein, we report on a liver transplant recipient and a renal transplant recipient with multiple large ulcers in the distal ileum and ileocecal valve who rapidly achieved ulcer healing upon withdrawal of sirolimus or tacrolimus and administration of thalidomide. in case 1, a 56-year-old man with primary h ... | 2016 | 27350740 |
| an epstein-barr virus-encoded protein complex requires an origin of lytic replication in cis to mediate late gene transcription. | epstein-barr virus lytic replication is accomplished by an intricate cascade of gene expression that integrates viral dna replication and structural protein synthesis. most genes encoding structural proteins exhibit "true" late kinetics-their expression is strictly dependent on lytic dna replication. recently, the ebv bcrf1 gene was reported to encode a tata box binding protein homolog, which preferentially recognizes the tatt sequence found in true late gene promoters. bcrf1 is one of seven ebv ... | 2016 | 27348612 |
| diagnosis and management of extranodal nk/t cell lymphoma nasal type. | extranodal nk/t-cell lymphoma nasal type is a distinct clinicopathologic entity. the most common initial site of presentation is the nasopharyngeal area, but non-nasals sites including the skin and the gastrointestinal tract may be affected. | 2016 | 27347812 |
| an overview of infectious complications after allogeneic hematopoietic stem cell transplantation. | infections are the most common and significant cause of mortality and morbidity after allogeneic hematopoietic stem cell transplantation (allo-hsct). the presence of neutropenia and mucosal damage are the leading risk factors in the early pre-engraftment phase. in the early post-engraftment phase, graft versus host disease (gvhd) induced infection risk is increased in addition to catheter related infections. in the late phase, in which reconstitution of cellular and humoral immunity continues, a ... | 2016 | 27344206 |
| atypical manifestations of epstein-barr virus: red alert for primary immunodeficiencies. | 2017 | 27343635 | |
| authors' reply: atypical manifestations of epstein-barr virus: red alert for primary immunodeficiencies. | 2017 | 27343634 | |
| low density of cd204-positive m2-type tumor-associated macrophages in epstein-barr virus-associated gastric cancer: a clinicopathologic study with digital image analysis. | recent studies suggest that cd204-positive (cd204(+)) m2-type tumor-associated macrophages (tams) are associated with the aggressive behavior of various cancers. however, the clinicopathologic significance of tumor-infiltrating cd204(+) macrophages and their correlation with epstein-barr virus (ebv) in gastric cancer is unclear. tissue microarrays were constructed from 119 surgically resected gastric cancer specimens (86 ebv-negative and 28 ebv-positive cases). after immunohistochemistry of cd20 ... | 2016 | 27342912 |
| immunohistochemistry as a surrogate for molecular subtyping of gastric adenocarcinoma. | the cancer genome atlas research network recently classified gastric adenocarcinoma into 4 molecular subtypes: epstein-barr virus-positive tumors, microsatellite-unstable tumors, tumors with chromosomal instability, and genomically stable tumors. we theorized that immunohistochemistry might be useful in similar categorization and that that her2 expression might relate to subtype. we stained 104 gastric adenocarcinomas for mlh1, p53, and eber in situ hybridization. we grouped them based on staini ... | 2016 | 27342907 |
| physical activity, sedentary behaviors, and epstein-barr virus antibodies in young adults. | this study aimed to elucidate the associations between physical activity, sedentary behaviors, and epstein-barr virus (ebv) antibody levels (as an indirect marker of cell-mediated immunity, cmi). this study made use of a 14-year longitudinal study with a representative sample of adolescents in the us. a total of 3361 participants (42.1% male) aged 11 to 21years at baseline who completed wave i (1994-1995), wave iii (2001-2002), and wave iv (2008) surveys of the national longitudinal study of ado ... | 2016 | 27342426 |
| epstein-barr virus-associated smooth muscle tumor of the cavernous sinus: a delayed complication of allogenic peripheral blood stem cell transplantation: case report. | epstein-barr virus (ebv)-associated smooth muscle tumors (smts) have recently been associated with primary and secondary immunodeficiencies. they are broadly divided into 3 subgroups: hiv-related, posttransplant, and congenital immunodeficiency. subsequent to organ transplantation and acquired immunosuppression, a few cases of ebv-associated smts have been described in the liver, respiratory tract, and gastrointestinal system. to the authors' knowledge, intracranial involvement after peripheral ... | 2016 | 27341041 |
| divergent viral presentation among human tumors and adjacent normal tissues. | we applied a newly developed bioinformatics system called virusscan to investigate the viral basis of 6,813 human tumors and 559 adjacent normal samples across 23 cancer types and identified 505 virus positive samples with distinctive, organ system- and cancer type-specific distributions. we found that herpes viruses (e.g., subtypes hhv4, hhv5, and hhv6) that are highly prevalent across cancers of the digestive tract showed significantly higher abundances in tumor versus adjacent normal samples, ... | 2016 | 27339696 |
| targeting epstein-barr virus-transformed b lymphoblastoid cells using antibodies with t-cell receptor-like specificities. | epstein-barr virus (ebv) is an oncovirus associated with several human malignancies including posttransplant lymphoproliferative disease in immunosuppressed patients. we show here that anti-ebv t-cell receptor-like monoclonal antibodies (tcr-like mabs) e1, l1, and l2 bound to their respective hla-a*0201-restricted ebv peptides ebna1562-570, lmp1125-133, and lmp2a426-434 with high affinities and specificities. these mabs recognized endogenously presented targets on ebv b lymphoblastoid cell lines ... | 2016 | 27338099 |
| regulation of ebv lmp1-triggered epha4 downregulation in ebv-associated b lymphoma and its impact on patients' survival. | epstein-barr virus (ebv), an oncogenic human virus, is associated with several lymphoproliferative disorders, including burkitt lymphoma, hodgkin disease, diffuse large b-cell lymphoma (dlbcl), and posttransplant lymphoproliferative disorder (ptld). in vitro, ebv transforms primary b cells into lymphoblastoid cell lines (lcls). recently, several studies have shown that receptor tyrosine kinases (rtks) play important roles in ebv-associated neoplasia. however, details of the involvement of rtks i ... | 2016 | 27338098 |
| validation of an optimized elisa for quantitative assessment of epstein-barr virus antibodies from dried blood spots. | our objective was to validate a commercially available elisa to measure antibody titers against epstein-barr virus (ebv) in dried blood spots (dbs) to replace a previously validated assay for dbs that is no longer available. we evaluated the precision, reliability, and stability of the assay for the measurement of ebv antibodies in matched plasma, fingerprick dbs, and venous blood dbs samples from 208 individuals. effects of hematocrit and dbs sample matrix on ebv antibody determination were als ... | 2016 | 27337556 |
| epstein-barr virus. | this review covers relevant clinical and laboratory information relating to epstein-barr virus (ebv) infections in immunocompromised hosts. it describes the epidemiology and clinical manifestations with a primary focus on disease in solid organ and stem cell transplant recipients. the review pays particular attention to diagnostic approaches, including serologic testing and imaging, with an expanded discussion on the role of measuring the ebv load in peripheral blood, identifying both strengths ... | 2016 | 27337443 |
| the association between antibodies to neurotropic pathogens and schizophrenia: a case-control study. | exposure to neurotropic pathogens has been proposed as an environmental risk factor for schizophrenia and can be evaluated by measuring pathogen-specific immunoglobulin g (igg). seroprevalence of pathogen-specific igg reflects prior exposure, whereas igg levels are associated with reactivity or reinfection. several studies have examined these parameters in schizophrenia. however, results still remain inconclusive, as several previous studies did not correct for important confounding factors. | 2015 | 27336045 |
| standardised incidence ratios (sirs) for cancer after renal transplant in systemic lupus erythematosus (sle) and non-sle recipients. | we investigated malignancy risk after renal transplantation in patients with and without systemic lupus erythematosus (sle). | 2016 | 27335659 |
| bzlf1 attenuates transmission of inflammatory paracrine senescence in epstein-barr virus-infected cells by downregulating tumor necrosis factor alpha. | recent studies have shown that inflammatory responses trigger and transmit senescence to neighboring cells and activate the senescence-associated secretory phenotype (sasp). latent epstein-barr virus (ebv) infection induces increased secretion of several inflammatory factors, whereas lytic infections evade the antiviral inflammatory response. however, the changes in and roles of the inflammatory microenvironment during the switch between ebv life cycles remain unknown. in the present study, we d ... | 2016 | 27334596 |
| post-transplant lymphoproliferative disorder in the pelvis successfully treated with consolidative radiotherapy. | post-transplant lymphoproliferative disorders (ptlds) are aggressive malignancies which represent one of the major post-transplant complications. however, treatment options vary significantly and localized disease may be curatively treated with radiotherapy (rt) or surgery. we report a case of recurrent rectal ptld, which was successfully treated by chemoimmunotherapy followed by rt. | 2017 | 27334275 |
| common infections with polyomaviruses and herpesviruses and neuropsychological development at 4 years of age, the rhea birth cohort in crete, greece. | viral infections of the central nervous system may have detrimental effects for the developing brain, but the effects of less virulent common infections are unclear. we aim to investigate the impact of common viral infections of early childhood on neuropsychological performance of children at age four. | 2016 | 27334233 |
| epstein-barr virus infection of mammary epithelial cells promotes malignant transformation. | whether the human tumor virus, epstein-barr virus (ebv), promotes breast cancer remains controversial and a potential mechanism has remained elusive. here we show that ebv can infect primary mammary epithelial cells (mecs) that express the receptor cd21. ebv infection leads to the expansion of early mec progenitor cells with a stem cell phenotype, activates met signaling and enforces a differentiation block. when mecs were implanted as xenografts, ebv infection cooperated with activated ras and ... | 2016 | 27333046 |
| comprehensive expression profiles of gastric cancer molecular subtypes by immunohistochemistry: implications for individualized therapy. | gastric cancer (gc) is a leading cause of death. we aim to establish a clinically relevant assay that encompasses recent molecular classifications and provides useful clinical information in a large cohort of gc patients. a consecutive series of 438 gc patients that underwent palliative chemotherapy between 2014 and 2015 were assessed using 10 gc panels: eber in-situ hybridization, immunohistochemistry for mismatch repair (mmr) proteins (mlh1, pms2, msh2, and msh6), receptor tyrosine kinases (rt ... | 2016 | 27331626 |
| integrity of genome-wide genotype data from low passage lymphoblastoid cell lines. | we compared genotype data from the humanexomecore array in peripheral blood mononuclear cells and low passage lymphoblastoid cell lines from the same 24 individuals to test for genotypic errors caused by the epstein-barr virus transformation process. genotype concordance across the 24 comparisons was 99.57% for unfiltered genotype data, and 99.63% following standard genotype quality control filters. mendelian error rates and levels of heterozygosity were not significantly different between lymph ... | 2016 | 27330997 |
| clinical utility of thallium-201 single photon emission computed tomography and cerebrospinal fluid epstein-barr virus detection using polymerase chain reaction in the diagnosis of aids-related primary central nervous system lymphoma. | to determine the diagnostic efficiency of thallium-201 single photon emission computed tomography (spect) and epstein-barr virus (ebv) polymerase chain reaction (pcr) in the differentiation of primary central nervous system lymphoma (pcnsl) from other central nervous system processes in patients with hiv/aids. | 2016 | 27330874 |
| esophageal metastasis secondary to extranodal nasal-type natural killer/t-cell lymphoma: a case report. | we herein report a case of recurrent nasal natural killer (nk)/t-cell lymphoma in a 21-year-old male patient. the patient presented with an esophageal mass, fever and difficulty in swallowing. there were no other obvious sites of recurrence apart from the esophageal lesion. metastatic esophageal lesions are extremely rare. the histological analysis demonstrated a highly aggressive tumor with a characteristic angiodestructive growth pattern and nasal cavity necrosis. the lymphoma cells were immun ... | 2016 | 27330799 |
| clinical association of baseline levels of conjugated dienes in low-density lipoprotein and nitric oxide with aggressive b-cell non-hodgkin lymphoma and their relationship with immunoglobulins and th1-to-th2 ratio. | the aim of this study was to highlight the clinical association of baseline levels of conjugated dienes in low-density lipoprotein (ldl-bcd) and nitric oxide (no) with immunoglobulins (igs) and t helper (th)1/th2 ratio in patients with newly diagnosed b-cell non-hodgkin lymphoma (nhl). | 2016 | 27330333 |
| effect of high-dose vitamin d3 supplementation on antibody responses against epstein-barr virus in relapsing-remitting multiple sclerosis. | elevated antibody levels against epstein-barr virus (ebv) and a poor vitamin d status are environmental factors that may interact in relapsing-remitting multiple sclerosis (rrms) aetiology. | 2017 | 27325604 |
| elevated plasma fibrinogen level shows superior prognostic value than epstein-barr virus dna load for stage iva/b nasopharyngeal carcinoma patients in the intensity-modulated radiotherapy era. | effective prognostic factors for patients with stage iva/b nasopharyngeal carcinoma (npc) who are susceptible to distant metastases are limited. we aim to investigate the prognostic value of pretreatment plasma fibrinogen (fib) level and epstein-barr virus dna (ebv-dna) load in these patients in the era of intensity-modulated radiotherapy (imrt). | 2016 | 27323828 |
| acute flaccid myelitis in the united states, august-december 2014: results of nationwide surveillance. | during late summer/fall 2014, pediatric cases of acute flaccid myelitis (afm) occurred in the united states, coincident with a national outbreak of enterovirus d68 (ev-d68)-associated severe respiratory illness. | 2016 | 27318332 |
| embelin prevents lmp1-induced trail resistance via inhibition of xiap in nasopharyngeal carcinoma cells. | the tumor necrosis factor-related apoptosis-inducing ligand (trail) selectively induces apoptosis in the majority of tumor cells, whilst sparing normal cells. however, the potential use of trail in the treatment of cancer is limited by the inevitable emergence of drug resistance. the present study reports the upregulation of latent membrane protein 1 (lmp1)-induced trail resistance via the enhanced expression of x-linked inhibitor of apoptosis protein (xiap) in nasopharyngeal carcinoma (npc) cel ... | 2016 | 27313761 |
| automated quantification of epstein-barr virus in whole blood of hematopoietic stem cell transplant patients using the abbott m2000 system. | accurate quantification of epstein-barr virus (ebv) load in blood is essential for the management of post-transplant lymphoproliferative disorders. the automation of dna extraction and amplification may improve accuracy and reproducibility. we evaluated the ebv pcr kit v1 with fully automated dna extraction and amplification on the m2000 system (abbott assay). | 2016 | 27312691 |
| viruses, anti-viral therapy, and viral vaccines in children with immune thrombocytopenia. | immune thrombocytopenia (itp) might be preceded by silent or overt viral infections. similarly, anti-viral drugs and viral vaccines could also trigger itp and might play a central role in its pathogenesis. the seasonal nature of childhood itp suggests that viral infections might initiate immune responses that increase the predisposition and occurrence of itp. active cytomegalovirus or epstein-barr virus should be considered in differential diagnosis when thrombocytopenia is associated with lymph ... | 2016 | 27312173 |
| peripheral t-cell lymphomas of follicular helper t-cell type frequently display an aberrant cd3(-/dim)cd4(+) population by flow cytometry: an important clue to the diagnosis of a hodgkin lymphoma mimic. | nodal follicular helper t-cell-derived lymphoproliferations (specifically the less common peripheral t-cell lymphomas of follicular type) exhibit a spectrum of histologic features that may mimic reactive hyperplasia or hodgkin lymphoma. even though angioimmunoblastic t-cell lymphoma and peripheral t-cell lymphoma of follicular type share a common biologic origin from follicular helper t-cells and their morphology has been well characterized, flow cytometry of peripheral t-cell lymphomas of folli ... | 2016 | 27312067 |
| regulation of viral oncogenesis by micrornas. | viral infection may play a causative role in human cancers, for example hepatitis b virus (hbv) or hepatitis c virus (hcv) in liver cancer, human papilloma virus (hpv) in cervical cancer, and epstein-barr virus (ebv) in nasopharyngeal carcinoma. virally infected cells express viral-encoded genes that are critical for oncogenesis. some viruses also encode microrna (mirna) species. mirnas are small noncoding rna molecules that play an important role in cancer development and progression. recent st ... | 2014 | 27308317 |
| role of leukemia inhibitory factor in nasopharyngeal carcinogenesis. | although epstein-barr virus-associated nasopharyngeal carcinoma (npc) is a highly radiosensitive cancer, approximately 20% of patients with npc develop local recurrence after radiation therapy. multiple proinflammatory cytokines are thought to protect npc tumor cells from immune surveillance and therapeutic interventions. the cytokine leukemia inhibitory factor (lif) is a critical component of the npc microenvironment. lif influences tumor growth and survival, and is therefore considered a poten ... | 2014 | 27308310 |
| csf herpes virus and autoantibody profiles in the evaluation of encephalitis. | to report the frequency of coexisting herpes viruses (herpes simplex virus 1 [hsv-1] or hsv-2, varicella zoster virus, epstein-barr virus [ebv], cytomegalovirus, or human herpes virus 6 [hhv-6]) and autoantibodies in patients with encephalitis (herpes or autoimmune) in clinical laboratory service. | 2016 | 27308306 |
| cytomegalovirus and langerhans cell histiocytosis: is there a link? | langerhans cell histiocytosis is a rare proliferative histiocytic disease of unknown etiology. histologically, it is characterized by granuloma-like proliferation of langerhans-type dendritic cells derived from bone marrow. many investigators have suggested the possible role of viruses such as epstein-barr virus, human herpesvirus-6 (hhv-6), herpes simplex virus (hsv) types 1 and 2, and cytomegalovirus in the pathogenesis of langerhans cell histiocytosis. | 2016 | 27307972 |
| latency-associated nuclear antigen e3 ubiquitin ligase activity impacts gammaherpesvirus-driven germinal center b cell proliferation. | viruses have evolved mechanisms to hijack components of cellular e3 ubiquitin ligases, thus modulating the ubiquitination pathway. however, the biological relevance of such mechanisms for viral pathogenesis in vivo remains largely unknown. here, we utilized murid herpesvirus 4 (muhv-4) infection of mice as a model system to address the role of muhv-4 latency-associated nuclear antigen (mlana) e3 ligase activity in gammaherpesvirus latent infection. we show that specific mutations in the mlana so ... | 2016 | 27307564 |
| systemic lupus erythematosus. | systemic lupus erythematosus (sle) is an autoimmune disease that can affect many organs, including the skin, joints, the central nervous system and the kidneys. women of childbearing age and certain racial groups are typically predisposed to developing the condition. rare, inherited, single-gene complement deficiencies are strongly associated with sle, but the disease is inherited in a polygenic manner in most patients. genetic interactions with environmental factors, particularly uv light expos ... | 2016 | 27306639 |
| [regulation and evasion of host immune responses by epstein-barr virus]. | epstein-barr virus (ebv) is the first identified human oncogenic dna virus in the gamma-herpesvirus family. ebv triggers a cascade events of innate immune responses through toll-like receptor signaling including the production of type i interferons and the activation of functional autophagy. however, ebv has developed much more elaborate and sophisticated strategies for subverting and escaping the host immune system, such as limiting its own gene expression, activing the host ubiquitin-specific ... | 2016 | 27305776 |
| chromatin remodeling factor lsh drives cancer progression by suppressing the activity of fumarate hydratase. | chromatin modification is pivotal to the epithelial-mesenchymal transition (emt), which confers potent metastatic potential to cancer cells. here, we report a role for the chromatin remodeling factor lymphoid-specific helicase (lsh) in nasopharyngeal carcinoma (npc), a prevalent cancer in china. lsh expression was increased in npc, where it was controlled by the epstein-barr virus-encoded protein lmp1. in npc cells in vitro and in vivo, lsh promoted cancer progression in part by regulating expre ... | 2016 | 27302170 |
| putative periodontopathic bacteria and herpesviruses in pregnant women: a case-control study. | little is known about herpesvirus and putative periodontopathic bacteria in maternal chronic periodontitis. the present case-control study aimed to explore the potential relationship between putative periodontopathic bacteria and herpesviruses in maternal chronic periodontitis.saliva samples were collected from 36 pregnant women with chronic periodontitis (cases) and 36 pregnant women with healthy periodontal status (controls). six putative periodontopathic bacteria (porphyromonas gingivalis [pg ... | 2016 | 27301874 |
| lessons learned from in vivo studies of a viral noncoding rna. | despite increasing interest in the biology of noncoding rnas (ncrnas), few functions have been uncovered for viral ncrnas in vivo. in their recent article in msphere, feldman and colleagues [e. r. feldman et al., msphere 1(2):e00105-15, 2016, doi:10.1128/msphere.00105-15] demonstrate a highly specific activity of a gammaherpesviral ncrna in viral dissemination and establishment of latent infection. their work highlights several interesting features that should be informative to future studies of ... | 2017 | 27301787 |
| a rare case of epstein-barr virus negative inflammatory pseudotumor-like follicular dendritic cell sarcoma presenting as a solitary colonic mass in a 53-year-old woman; case report and review of literature. | follicular dendritic cell (fdc) sarcoma is a rare neoplasm that occurs predominantly in lymph nodes. one third of fdc sarcomas happens in extranodal sites. there are 2 morphologic variants of this tumor: conventional and inflammatory pseudotumor (ipt)-like. ipt-like fdc sarcomas are reported mostly in females and usually involve the spleen and liver. in all cases of ipt-like fdc sarcoma the epstein-barr virus (ebv) was positive by in situ hybridization except one instance. we report a case of 53 ... | 2016 | 27299190 |
| lenalidomide, thalidomide, and pomalidomide reactivate the epstein-barr virus lytic cycle through phosphoinositide 3-kinase signaling and ikaros expression. | lenalidomide, thalidomide, and pomalidomide (ltp) are immunomodulatory agents approved for use in multiple myeloma, but in some settings, especially with alkylating agents, an increase in hodgkin lymphoma and other secondary primary malignancies (spm) has been noted. some of these malignancies have been linked to epstein-barr virus (ebv), raising the possibility that immunomodulatory drugs disrupt latent ebv infection. | 2016 | 27297582 |
| validation of an ifnγ/il2 fluorospot assay for clinical trial monitoring. | the fluorospot assay, an advancement of the elispot assay, enables simultaneous measurement of different analytes secreted at a single-cell level. this allows parallel detection of several cytokines secreted by immune cells upon antigen recognition. easier standardization, higher sensitivity and reduced labour intensity render fluorospot assays an interesting alternative to flow-cytometry based assays for analysis of clinical samples. while the use of immunoassays to study immunological primary ... | 2016 | 27297580 |
| [molecular mechanism of glycoprotein-induced cell-cell fusion of herpesviruses]. | herpesviridae is a large family comprising linear, double-stranded dna viruses. herpesviridae contains three subfamilies: α-, β- and γ-herpesviruses. the glycoproteins gb, gh and gl of each subfamily form the "core fusion function" in cell-cell fusion. other herpesviruses also need additional glycoproteins to promote fusion, such as gd of the herpes simplex virus, gp42 of the epstein-barr virus, and go or ul128-131 of the human cytomegalovirus. in contrast, glycoproteins gm or gm/gn of herpesvir ... | 2016 | 27295891 |
| effects of lactobacillus casei shirota ingestion on common cold infection and herpes virus antibodies in endurance athletes: a placebo-controlled, randomized trial. | to assess evidence of health and immune benefit by consumption of a lactobacillus casei shirota probiotic in highly physically active people. | 2016 | 27294502 |
| integration of hiv in the human genome: which sites are preferential? a genetic and statistical assessment. | chromosomal fragile sites (fss) are loci where gaps and breaks may occur and are preferential integration targets for some viruses, for example, hepatitis b, epstein-barr virus, hpv16, hpv18, and mlv vectors. however, the integration of the human immunodeficiency virus (hiv) in giemsa bands and in fss is not yet completely clear. this study aimed to assess the integration preferences of hiv in fss and in giemsa bands using an in silico study. hiv integration positions from jurkat cells were used ... | 2016 | 27294106 |
| rabbits immunized with epstein-barr virus gh/gl or gb recombinant proteins elicit higher serum virus neutralizing activity than gp350. | epstein-barr virus (ebv) is the primary cause of infectious mononucleosis and has been strongly implicated in the etiology of multiple epithelial and lymphoid cancers, such as nasopharyngeal carcinoma, gastric carcinoma, hodgkin lymphoma, burkitt lymphoma, non-hodgkin lymphoma and post-transplant lymphoproliferative disorder. there is currently no licensed prophylactic vaccine for ebv. most efforts to develop prophylactic vaccines have focused on ebv gp350, which binds to cd21/cd35 to gain entry ... | 2016 | 27291087 |
| a review of nationwide population study of organ transplantation in taiwan. | solid organ transplantation has become the therapy of choice for patients with end-stage organ disease. the frequently transplanted organs in taiwan include liver, kidney, heart, and lung, and the success rate has improved significantly worldwide for the past decades. however, organ recipients are known to be at a higher risk of post-transplant infections and de novo cancer due to immunosuppression and oncogenic viral infections. organ recipients are known to be at a two- to fourfold increased r ... | 2016 | 27289565 |
| hemophagocytic lymphohistiocytosis: pathogenesis, diagnosis, and management. | hemophagocytic lymphohistiocytosis (hlh) is a life-threatening hyperinflammatory syndrome that is classified into primary and secondary hlh. primary hlh consists of monogenic disorders that mainly affect the perforin-mediated cytotoxicity of cytotoxic t lymphocytes and natural killer cells. secondary hlh occurs as a complication in various settings such as infection, malignancy, autoimmune disease, and post-allogeneic hematopoietic stem cell transplantation. both primary and secondary hlh are ch ... | 2016 | 27289085 |
| variable clinical phenotypes of x-linked lymphoproliferative syndrome in china: report of five cases with three novel mutations and review of the literature. | x-linked lymphoproliferative disease (xlp) is a rare life-threatening syndrome. rapid recognition and definitive diagnosis are critical to improve the prognosis and survival of patients with xlp. nowadays, little is known about patients with xlp in china. | 2016 | 27288720 |
| two unrelated burkitt lymphomas seven years apart in a patient with x-linked lymphoproliferative disease type 1 (xlp1). | we describe a rare case of a male child with x-linked lymphoproliferative disease type 1 (xlp1) who presented with burkitt lymphoma (bl) when he was 6 years old, achieved a complete response to therapy, and developed a second bl after seven years. | 2016 | 27287777 |
| detection of malawi polyomavirus sequences in secondary lymphoid tissues from italian healthy children: a transient site of infection. | the novel malawi polyomavirus (mwpyv) was initially detected in stool specimens from healthy children and children with gastrointestinal symptoms, mostly diarrhea, indicating that mwpyv might play a role in human gastroenteric diseases. recently, mwpyv sequences were additionally identified in respiratory secretions from both healthy and acutely ill children suggesting that mwpyv may have a tropism for different human tissues. this study was designed to investigate the possible sites of latency/ ... | 2016 | 27287743 |
| virus-associated haemophagocytic lymphohistiocytosis in a young filipino man. | haemophagocytic lymphohistiocytosis (hlh) is a rare syndrome of pathological immune activation characterised by extreme inflammation. we present a case of a young filipino man consulting for non-specific symptoms of fever, body malaise and weight loss. prominent physical examination findings included gross pallor, cachexia and hepatosplenomegaly. laboratory results revealed pancytopaenia, while bone marrow examination revealed haemophagocytosis. further workup for hlh showed hypertriglyceridaemi ... | 2016 | 27284096 |
| the epithelial-mesenchymal transition (emt) is regulated by oncoviruses in cancer. | the epithelial-mesenchymal transition (emt), defined as transdifferentiation of epithelial cells into mesenchymal cells, is critical for embryonic development, wound healing, tissue regeneration, organ fibrosis, and cancer progression. recently, the role of emt in carcinogenesis has attracted much attention. oncoviruses, including human papillomaviruses (hpvs), epstein-barr virus (ebv), and hepatitis b and c viruses (hbvs, hcvs), are known to be involved in the etiology of cancer and have been f ... | 2016 | 27279361 |
| pulmonary manifestation of immunoglobulin g4-related disease in a 7-year-old immunodeficient boy with epstein-barr virus infection: a case report. | immunoglobulin g4-related disease (igg4-rd) is a multiorgan fibroinflammatory condition with lymphoplasmacytic infiltrates containing abundant igg4-positive plasma cells. the immunopathogenesis of the disease and the potential role of triggering autoantigens or infectious factors have not been clearly defined. immunoglobulin g4-related lung disease is a new and emerging condition in pediatric patients and to date, there have been only two reports regarding pulmonary manifestation of igg4-rd in c ... | 2016 | 27277432 |
| clinical and laboratory differences between epstein-barr and cytomegalovirus infectious mononucleosis in children. | infective mononucleosis is most commonly caused by epstein-barr virus (ebv), and in smaller percentage by cytomegalovirus (cmv). | 2016 | 27276859 |
| dress syndrome with autoimmune hepatitis from strontium ranelate. | strontium ranelate, which is used for postmenopausal osteoporosis, has been associated with drug rash with eosinophilia and systemic symptoms (dress) syndrome, a severe, acute, potentially fatal, multisystem adverse drug reaction characterized by skin rash, fever, hematological abnormalities, and lymphadenopathy with involvement of several internal organs. we report the case of a woman who developed dress syndrome with a generalized maculopapular rash, eosinophilia, dyspnea, bilateral cervical l ... | 2016 | 27274555 |
| the role of micrornas in the pathogenesis of herpesvirus infection. | micrornas (mirnas) are small non-coding rnas important in gene regulation. they are able to regulate mrna translation through base-pair complementarity. cellular mirnas have been involved in the regulation of nearly all cellular pathways, and their deregulation has been associated with several diseases such as cancer. given the importance of micrornas to cell homeostasis, it is no surprise that viruses have evolved to take advantage of this cellular pathway. viruses have been reported to be able ... | 2016 | 27271654 |
| associations between inflammatory cytokines and organ damage in pediatric patients with hemophagocytic lymphohistiocytosis. | hemophagocytic lymphohistiocytosis (hlh) is a potentially fatal disease characterized by overwhelming inflammation response and multiple organ damage. most of the clinical and laboratory manifestations of hlh are thought to be related to hypercytokinemia and organ infiltration with lymphocytes and histiocytes. the aim of this study was to investigate the associations between cytokines and various manifestations of hlh. a total of 105 patients diagnosed with hlh were enrolled in this retrospectiv ... | 2016 | 27269180 |
| detection of epstein-barr virus and cytomegalovirus in gastric cancers in kerman, iran. | gastric cancer (gc) is a multifactorial disease with different factors having roles in its genesis. helicobacter pylori and epstein-barr virus (ebv) are known infectious agents that could contribute. in addition, there is evidence of a relationship with cytomegalovirus (cmv). since data on cmv prevalence in gastric cancer are limited, we here evaluated the frequency of ebv and cmv in iranian patients. ninety paraffin blocks of gc tissues from patients in kerman were evaluated for the presence of ... | 2016 | 27268608 |
| epstein-barr virus infection is associated to patients with multiple myeloma and monoclonal gammopathy of undetermined significance. | 2017 | 27268403 | |
| association of ddx58 177 c > t polymorphism with decreased risk of epstein-barr virus-related nodular sclerosis classical hodgkin lymphoma. | classical hodgkin lymphoma (chl) is frequently related to epstein-barr virus (ebv) infection. its malignant capacity is attributed to disruption of an ebv-host balance influenced by environmental and genetic drivers. ebv structures activate type i interferon (ifn) pathway of the innate immunity, therefore, genetic polymorphisms could influence this response. we explored the impact of four single nucleotide polymorphisms (snps) on ebv-associated chl susceptibility. toll-like receptors 9 (tlr9_rs5 ... | 2017 | 27267403 |
| primary squamous cell carcinoma of the stomach: a case report and review of the literature. | primary gastric squamous cell carcinoma (pgscc) is an exceedingly rare disease, accounting for 0.04% - 0.07% of all gastric cancers. first reported in 1895 by rörig et al, less than 100 cases of pgscc worldwide have been reported in the literature. these reports show pgscc is more common in males (5:1 male to female ratio), and exhibits a peak incidence in the sixth decade of life. it may involve any portion of the stomach with predilection for the proximal stomach, especially along the lesser c ... | 2016 | 27265923 |
| epstein-barr virus in hodgkin's disease patients in northeast anatolia. | epstein-barr virus (ebv) is implicated as an etiologic factor in hodgkin's disease (hd). the proportion of hd patients with ebv is high in developing countries but low in developed countries. in the present study, the ebv association with hd in northeast anatolia was investigated. thirty-six formalin-fixed paraffin-embedded cases of hd were analysed for the presence of ebv and, for the latent membrane protein (lpm-1) by immunohistochemistry. there were 26 males and 10 females; age distribution r ... | 2000 | 27265855 |
| interferon-β therapy specifically reduces pathogenic memory b cells in multiple sclerosis patients by inducing a fas-mediated apoptosis. | growing evidences put b lymphocytes on a central stage in multiple sclerosis (ms) immunopathology. while investigating the effects of interferon-β (ifn-β) therapy, one of the most used first-line disease-modifying drugs for the treatment of relapsing-remitting ms, in circulating b-cell sub-populations, we found a specific and marked decrease of cd27(+) memory b cells. interestingly, memory b cells are considered a population with a great disease-driving relevance in ms and resulted to be also ta ... | 2016 | 27265253 |
| detection of epstein barr virus in hodgkin's disease in trakya region of turkey; by in situ hybridization. | the relation of epstein-barr virus (ebv) and hodgkin's disease (hd) has been suggested by serologic, epidemiological and molecular biologic studies. according to these studies the incidence of ebv in hd is high. in the present study, the ebv association with hd in trakya region of turkey was investigated. we investigated the presence of ebv in 44 cases of hd. fluorescein-labelled antisense ebv (eber-rna) was performed by in situ hybridization. there were 28 males and 16 females, with a mean age ... | 2002 | 27265187 |