Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| epigenetic impact on ebv associated b-cell lymphomagenesis. | epigenetic modifications leading to either transcriptional repression or activation, play an indispensable role in the development of human cancers. epidemiological study revealed that approximately 20% of all human cancers are associated with tumor viruses. epstein-barr virus (ebv), the first human tumor virus, demonstrates frequent epigenetic alterations on both viral and host genomes in associated cancers-both of epithelial and lymphoid origin. the cell type-dependent different ebv latent gen ... | 2016 | 27886133 |
| 2,3,7,8-tetrachlorodibenzo-p-dioxin and the viral infection. | exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd), a widespread highly toxic environmental contaminant, suppresses immune response and leads to an increased susceptibility to infectious agents. in particular, several studies have provided evidence that tcdd decreases resistance to numerous viruses. indeed, in vivo and in vitro investigations showed that the presence of tcdd is able to interfere with the replication of both human and animal viruses, such as influenza a viruses, coxsackie vir ... | 2017 | 27883971 |
| epstein-barr virus associated hemophagocytic syndrome after scrub typhus infection. | there have been a small number of cases of scrub typhus-associated hemophagocytic syndrome (hps), most of which were treated successfully using adequate antibiotics. here, we report a case of epstein-barr virus (ebv)-associated hps after scrub typhus infection that was not improved using antirickettsial treatment. a 73-year-old male who had been diagnosed with scrub typhus according to an eschar and a positive serology was transferred to our institution because of a persistent fever despite 7-da ... | 2016 | 27883370 |
| novel biomarkers of nasopharyngeal carcinoma metastasis risk identified by reverse phase protein array based tumor profiling with consideration of plasma epstein-barr virus dna load. | in patients with epstein-barr virus (ebv) associated nasopharyngeal carcinoma (npc), intertumor heterogeneity causes interpatient heterogeneity in the risk of distant metastasis. we aimed to identify novel biomarkers of metastasis risk using reverse phase protein array (rppa) profiling of npc patients at risk for metastasis and considering plasma ebv dna load. | 2016 | 27883284 |
| sjögren's syndrome complicated by myeloid/natural killer cell precursor acute leukemia: case report and review of the literature. | we report a case of sjögren's syndrome (ss) complicated by myeloid/natural killer (nk) cell precursor acute leukemia (m/nkpal). a 75-year-old woman with a previous ss history for 2 years was routinely treated. peripheral blood progenitor cells were increased, and subsequent bone marrow cell morphology examination showed the presence of acute myeloid leukemia type m4. however, flow cytometry analysis revealed that cd7/cd56/cd33/cd34/hla-dr/ccd3 were all positive and myeloperoxidase- (mpo-) specif ... | 2016 | 27882252 |
| epstein-barr virus in nasopharyngeal carcinoma of guatemalan and brazilian patients. | nasopharyngeal carcinoma (npc) is highly associated with epstein-barr virus (ebv), particularly the undifferentiated nonkeratinizing subtype. prevalence of ebv in npc in countries such as guatemala and brazil has not been studied. | 2016 | 27881609 |
| nivolumab in the treatment of hodgkin lymphoma. | despite an extensive immune infiltrate that is recruited to the tumor by malignant reed-sternberg cells in hodgkin lymphoma, the antitumor immune response is ineffective and unable to eradicate the malignant cells. the ineffective immune response is in part due to pd-1 signaling that renders intratumoral immune cells anergic. reed-sternberg cells have been shown to upregulate expression of the pd-1 ligands, pd-l1 and pd-l2, due to either genetic alterations at chromosome 9p24.1 or epstein-barr v ... | 2017 | 27881581 |
| epstein-barr virus-associated mucocutaneous ulcer in a patient with t-cell acute lymphoblastic leukemia: importance of accurate diagnosis and conservative management. | epstein-barr virus-associated mucocutaneous ulcer (ebv-mcu) is a recently characterized entity that falls under the spectrum of ebv-lymphoproliferative disorders. first described in 2010 by dojcinov et al, it is an ebv-driven localized proliferation of b cells, occurring in mucocutaneous tissues including the skin, the oropharynx, and the gastrointestinal tract of immunosuppressed patients in the absence of an intact t-cell repertoire. typically, it has been described in elderly patients with ag ... | 2016 | 27879545 |
| clinically mild encephalitis/encephalopathy with a reversible splenial lesion accompanied by epstein-barr virus hemophagocytic lymphohistiocytosis: a case report and review of the literature. | central nervous system involvement in hemophagocytic lymphohistiocytosis (hlh) is associated with a poor outcome. for such patients, it is unknown whether more aggressive therapies, such as intrathecal methotrexate or hydrocortisone, are inevitably required. we present a very rare case of 3-year-old japanese girl who developed mild encephalitis/encephalopathy with a reversible splenial lesion, accompanied by epstein-barr virus-associated hlh, and review previous similar reports. our case and pre ... | 2017 | 27879539 |
| cerebrospinal fluid anti-epstein-barr virus specific oligoclonal igm and igg bands in patients with clinically isolated and guillain-barré syndrome. | epstein-barr virus (ebv) has been implicated in multiple sclerosis (ms) pathogenesis. we aimed to assess the frequency of ebv-specific igg and igm oligoclonal bands (ocb) in cerebrospinal fluid (csf) of 50 patients with clinically isolated syndrome (cis) and in 27 controls with guillain-barré syndrome (gbs). furthermore, we assessed correlations between the presence of ocb and cis patients' csf, mri, and clinical variables. there was no difference in the proportion of cis and gb patients with po ... | 2017 | 27878471 |
| regulation of wnt/β-catenin signaling by herpesviruses. | the wnt/β-catenin signaling pathway is instrumental in successful differentiation and proliferation of mammalian cells. it is therefore not surprising that the herpesvirus family has developed mechanisms to interact with and manipulate this pathway. successful coexistence with the host requires that herpesviruses establish a lifelong infection that includes periods of latency and reactivation or persistence. many herpesviruses establish latency in progenitor cells and viral reactivation is linke ... | 2016 | 27878101 |
| epstein-barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis. | epstein-barr virus (ebv) has been associated with several types of human cancers. in the host, ebv can establish two alternative modes of life cycle, known as latent or lytic and the switch from latency to the lytic cycle is known as ebv reactivation. although ebv in cancer cells is found mostly in latency, a small number of lytically-infected cells promote carcinogenesis through the release of growth factors and oncogenic cytokines. this review focuses on the mechanisms by which ebv reactivatio ... | 2016 | 27877083 |
| ebv-directed t cell therapeutics for ebv-associated lymphomas. | epstein barr virus (ebv) is a human gamma herpes virus that establishes latency in b cells after primary infection. ebv generally only causes a mild, self-limiting viral illness but is also associated with several malignancies including posttransplantation lymphoproliferative disorder in the immunosuppressed host as well as hodgkin and non-hodgkin lymphoma in the immune competent host. the expression of ebv antigens by lymphoma has important applications as targets for adoptive t cell therapy. h ... | 2017 | 27873282 |
| generation and analysis of humanized mouse model of ebv infection. | the recent development of severely immunodeficient mouse strains enabled the production of new-generation humanized mice, in which major components of the human immune system are reconstituted. these new-generation humanized mice can be infected with human pathogenic viruses that do not infect regular mice and target cells of the hematoimmune system. here we describe the method for preparing humanized mice, infecting them with ebv, and for their virological and immunological analyses. the result ... | 2017 | 27873281 |
| mice with reconstituted human immune system components as a tool to study immune cell interactions in ebv infection. | recent developments in mouse models that harbor part of a human immune system have proved extremely valuable to study the in vivo immune response to human specific pathogens such as epstein-barr virus. over the last decades, advances in immunodeficient mouse strains that can be used as recipients for human immune cells have greatly enhanced the use of these models. here, we describe the generation of mice with reconstituted human immune system (his mice) using immunocompromised mice transplanted ... | 2017 | 27873280 |
| characterization of ebv promoters and coding regions by sequencing pcr-amplified dna fragments. | dna sequencing approaches originally developed in two directions, the chemical degradation method and the chain-termination method. the latter one became more widespread and a huge amount of sequencing data including whole genome sequences accumulated, based on the use of capillary sequencer systems and the application of a modified chain-termination method which proved to be relatively easy, fast, and reliable. in addition, relatively long, up to 1000 bp sequences could be obtained with a singl ... | 2017 | 27873276 |
| terminal repeat analysis of ebv genomes. | epstein-barr virus (ebv) was the first human virus associated directly with human malignancies. during ebv infection of various host cells the double-stranded linear ebv dna carried by the virions undergoes circularization. since there are variable numbers of terminal repetitions (trs) at the ends of the linear ebv genome, the resulting circular episomes enclose a variable number of trs. thus, in cells carrying viral episomes, the sizes of the terminal restriction enzyme fragments of ebv is affe ... | 2017 | 27873275 |
| isolation and characterization of exosomes released by ebv-immortalized cells. | epstein-barr virus is an oncogenic herpesvirus associated with several human malignancies. although the details of the molecular steps involved in ebv-mediated cell transformation and immune evasion are not fully known, a number of viral products, including ebv latent proteins and non-protein coding rnas have been shown to be involved, directly or indirectly in these processes. in recent years, a growing body of data indicates that some viruses are able to transport selected products to neighbor ... | 2017 | 27873273 |
| analysis of ebv transcription using high-throughput rna sequencing. | high-throughput sequencing of rna is used to analyze the transcriptomes of viruses and cells, providing information about transcript structure and abundance. a wide array of programs and pipelines has been created to manage and interpret the abundance of data generated from high-throughput rna sequencing experiments. this protocol details the use of free and open-source programs to align rna-seq reads to a reference genome, visualize read coverage and splice junctions, estimate transcript abunda ... | 2017 | 27873270 |
| affinity purification-mass spectroscopy methods for identifying epstein-barr virus-host interactions. | considerable insight into the function and mechanism of action of viral proteins has come from identifying the cellular proteins with which they interact. in recent years, mass spectrometry-based methods have emerged as the method of choice for protein interaction discovery due to their comprehensive and unbiased nature. methods involving single affinity purifications of epitope-tagged viral proteins (ap-ms) and tandem affinity purifications of viral proteins with two purification tags (tap tagg ... | 2017 | 27873268 |
| generation and infection of organotypic cultures with epstein-barr virus. | while numerous model systems are available to study ebv latency in b cells and have contributed greatly to our understanding of the role of these cells in the viral life cycle, models to study the ebv life cycle in epithelial cells in vitro are lacking. epithelial cells are poorly infected in vitro, and ebv-infected cell lines have not been successfully obtained from epithelial tumors. recently, we have demonstrated that organotypic cultures of oral keratinocytes can be used as a model to study ... | 2017 | 27873267 |
| epstein-barr virus: clinical diagnostics. | the vast majority of the human adult population is infected with epstein-barr virus (ebv), and the majority of the ebv-infected individuals tolerates the infection well, without any further symptoms after primary infection. in cases of individuals which undergo primary infection in the form of an infectious mononucleosis, or which have undergone primary infection in their past, it is sometimes important to appraise symptomatic disease or differentiate infectious mononucleosis from other conditio ... | 2017 | 27873265 |
| current trends and alternative scenarios in ebv research. | epstein-barr virus (ebv) infection is associated with several distinct hematological and epithelial malignancies, e.g., burkitt lymphoma, hodgkin lymphoma, nasopharyngeal carcinoma, gastric carcinoma, and others. the association with several malignant tumors of local and worldwide distribution makes ebv one of the most important tumor viruses. furthermore, because ebv can cause posttransplant lymphoproliferative disease, transplant medicine has to deal with ebv as a major pathogenic virus second ... | 2017 | 27873264 |
| pulmonary lymphomatoid granulomatosis- a case report with review of literature. | lymphomatoid granulomatosis is a rare, epstein barr virus (ebv)-associated systemic angiodestructive disorder that may progress to a diffuse large b cell lymphoma. pulmonary involvement occurs in over 90 % cases followed by kidney, skin and brain. who classifies lymphomatoid granulomatosis under the generic heading of b cell proliferations of uncertain malignant potential. radiologically, pulmonary lymphomatoid granulomatosis (plg) presents with non specific findings making histopathology the go ... | 2016 | 27872542 |
| expanding diversity in molecular structures and functions of the il-6/il-12 heterodimeric cytokine family. | the interleukin (il)-6/il-12 family cytokines have pleiotropic functions and play critical roles in multiple immune responses. this cytokine family has very unique characteristics in that they comprise two distinct subunits forming a heterodimer and each cytokine and receptor subunit shares with each other. the members of this cytokine family are increasing; currently, there are more than six cytokines, including the tentatively named cytokines il-y (p28/p40), il-12 (p35/p40), il-23 (p19/p40), i ... | 2016 | 27867385 |
| viral carcinogenesis. | cancer has been recognized for thousands of years. egyptians believed that cancer occurred at the will of the gods. hippocrates believed human disease resulted from an imbalance of the four humors: blood, phlegm, yellow bile, and black bile with cancer being caused by excess black bile. the lymph theory of cancer replaced the humoral theory and the blastema theory replaced the lymph theory. rudolph virchow was the first to recognize that cancer cells like all cells came from other cells and beli ... | 2016 | 27865457 |
| ebv infection is prevalent in the adenoid and palatine tonsils in adults. | epstein-barr virus (ebv) is associated with the pathogenesis of several diseases in both adults and children. however, there have been no reports on the prevalence and amount of ebv in the adenoids of adults; thus, it is important to investigate these in the adenoids and tonsils of adults and children. in this study, 67 patients who underwent tonsillectomy or adenotonsillectomy were included and divided into two groups: adults aged ≥ 16 years (n = 35) and children aged <16 years (n = 32). patien ... | 2016 | 27864888 |
| epstein-barr virus infection and gene promoter hypermethylation in rheumatoid arthritis patients with methotrexate-associated b cell lymphoproliferative disorders. | we analyzed cpg-island hypermethylation status in 12 genes of paraffin-embedded tissues from 38 rheumatoid arthritis (ra) patients with methotrexate (mtx)-associated large b cell lymphoproliferative disorder (blpd), 11 ra patients with non-mtx-associated blpd (non-mtx-blpd), 22 controls with diffuse large b cell lymphoma (dlbcl), and 10 controls with epstein-barr virus (ebv)(+) dlbcl. among them, tumor cells from ebv(+) mtx-blpd patients and control ebv(+) dlbcl patients had significantly lower ... | 2017 | 27864689 |
| epstein-barr virus super-enhancer ernas are essential for myc oncogene expression and lymphoblast proliferation. | epstein-barr virus (ebv) super-enhancers (eses) are essential for lymphoblastoid cell (lcl) growth and survival. reanalyses of lcl global run-on sequencing (gro-seq) data found abundant enhancer rnas (ernas) being transcribed at eses. inactivation of ese components, ebv nuclear antigen 2 (ebna2) and bromodomain-containing protein 4 (brd4), significantly decreased ernas at eses -428 and -525 kb upstream of the myc oncogene transcription start site (tss). shrna knockdown of the myc -428 and -525 e ... | 2016 | 27864512 |
| chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (clippers) with intracranial epstein-barr virus infection: a case report. | chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (clippers) is an inflammatory disorder in the central nervous system (cns) with distinct clinical, radiological, and pathological features. the pathophysiology of clippers still remains unclear and the reports are quite few. although the radiological lesions were reported to be located predominantly in the pons, brachium pontis, and cerebellum, other adjacent structures such as the white matter and spin ... | 2016 | 27861371 |
| metformin and esophageal cancer risk in taiwanese patients with type 2 diabetes mellitus. | this study evaluated whether metformin might reduce esophageal cancer risk. patients with type 2 diabetes mellitus diagnosed during 1999-2005 were recruited from the reimbursement database of taiwan's national health insurance. those newly treated with metformin (n = 288013, "ever users of metformin") or other antidiabetic drugs (n = 16216, "never users of metformin") were followed until december 31, 2011. sensitivity analyses were conducted in a matched-pair sample of 16216 never users and 1621 ... | 2016 | 27861146 |
| mouse model for acute epstein-barr virus infection. | epstein-barr virus (ebv) infects human b cells and drives them into continuous proliferation. two key viral factors in this process are the latent membrane proteins lmp1 and lmp2a, which mimic constitutively activated cd40 receptor and b-cell receptor signaling, respectively. ebv-infected b cells elicit a powerful t-cell response that clears the infected b cells and leads to life-long immunity. insufficient immune surveillance of ebv-infected b cells causes life-threatening lymphoproliferative d ... | 2016 | 27856754 |
| maternal antibodies to herpes virus antigens and risk of gastroschisis in offspring. | gastroschisis risk is highest in offspring of young women and is increasing in prevalence, suggesting that exposures that are increasingly common among younger females may be causal. some infections by viruses in the herpes family are more common in the earlier childbearing years and have been increasing in prevalence over time. data from the finnish maternity cohort were linked to finnish malformation and birth registers (1987-2012) for this study, a nested case-control study of mothers of offs ... | 2016 | 27856447 |
| the epstein-barr virus immunoevasins bcrf1 and bplf1 are expressed by a mechanism independent of the canonical late pre-initiation complex. | subversion of host immune surveillance is a crucial step in viral pathogenesis. epstein-barr virus (ebv) encodes two immune evasion gene products, bcrf1 (viral il-10) and bplf1 (deubiquitinase/deneddylase); both proteins suppress antiviral immune responses during primary infection. the bcrf1 and bplf1 genes are expressed during the late phase of the lytic cycle, an essential but poorly understood phase of viral gene expression. several late gene regulators recently identified in beta and gamma h ... | 2016 | 27855219 |
| incidental ebv-positivity in paediatric post-transplant specimens demonstrates the need for stringent criteria for diagnosing post-transplant lymphoproliferative disorders. | to examine the need for minimal diagnostic criteria for post-transplant lymphoproliferative disorders (ptld) in children, we sought to determine the rate of incidental epstein-barr virus (ebv)-positivity in tissues from organ transplant recipients (otr). | 2017 | 27852687 |
| progress in quantitative viral load testing: variability and impact of the who quantitative international standards. | it has been hoped that the recent availability of who quantitative standards would improve interlaboratory agreement for viral load testing; however, insufficient data are available to evaluate whether this has been the case. results from 554 laboratories participating in proficiency testing surveys for quantitative pcr assays of cytomegalovirus (cmv), epstein-barr virus (ebv), bk virus (bkv), adenovirus (adv), and human herpesvirus 6 (hhv6) were evaluated to determine overall result variability ... | 2017 | 27852673 |
| a complicated course of acute viral induced pharyngitis, icteric hepatitis, acalculous cholecystitis, and skin rash. | this case reveals the complexities and challenges in the diagnosis of acute epstein-barr virus (ebv) infection, indicating the potential relationship between ebv infection and severe icteric hepatitis, acalculous cholecystitis, and lymphocytic vasculitis. we suggest including ebv infectious mononucleosis in the list of differential diagnoses when any of these clinical syndromes (or a combination thereof) occurs without apparent cause, especially in the presence of lymphocytosis. to our knowledge ... | 2016 | 27847520 |
| the epstein-barr virus ebna2 protein induces a subset of notch target genes in thyroid cancer cell lines but fails to suppress proliferation. | epstein-barr virus is associated with lymphoid and epithelial malignancies and has been reported to infect thyroid cells. the epstein-barr virus protein, ebna2, regulates viral and cellular promoters by binding to rbp-jκ. similarly, notch1, a tumor suppressor protein in thyroid epithelial cells, competes with ebna2 for binding to overlapping sites on rbp-jκ. ebna2 activates a subset of notch-responsive genes in lymphocytes and myocytes; however, the effect of ebna2 expression on notch targets in ... | 2017 | 27847111 |
| prognostic factors of methotrexate-associated lymphoproliferative disorders associated with rheumatoid arthritis and plausible application of biological agents. | to determine prognostic factors of methotrexate-associated lymphoproliferative disorder (mtx-lpd) and evaluate the efficacy and safety of biological therapy in rheumatoid arthritis (ra) complicated with mtx-lpd. | 2016 | 27846761 |
| a human fab exclusively binding to the extracellular domain of lmp2a. | in the areas of north africa, southeast asia as well as south china, nasopharyngeal carcinoma (npc) is among the most widespread cancers. plenty of research findings confirmed that epstein-barr virus (ebv) played a crucial role in npc. ebv-encoded latent membrane protein 2a (lmp2a) which continuously expressed in cell membrane protein induced an epithelial-mesenchymal transition and increased the number of side population stem-like cancer cells in npc. this reveals that lmp2a could contribute to ... | 2017 | 27845040 |
| epstein-barr virus associated primary intracranial leiomyoma in a patient with human immunodeficiency virus. | a leiomyoma is a low-grade tumor originating from smooth-muscle cells. primary intracranial leiomyoma is extremely rare and usually reported in immunocompromised patients. we present a case of primary intracranial leiomyoma in a 44-year-old male with a chief complaint of headache. the pathological analysis and relevant literature has been discussed. | 2016 | 27841145 |
| regulation of the viral life cycle by murine gammaherpesvirus 68 micrornas. | γ-herpesviruses (γhv) such as epstein-barr virus and kaposi's sarcoma-associated herpesvirus are important human pathogens involved in lymphoproliferation and tumorigenesis. murine gammaherpesvirus 68 (mhv-68, γhv-68) is an effective model for the study of γhv pathogenesis and host-virus interaction because it is closely related to human γhv. similarly to human γhv, mhv-68 encodes 15 micrornas (mirnas). although their functions remain unknown, they are thought to regulate the viral life cycle or ... | 2017 | 27837274 |
| ebv infection and multiple sclerosis: lessons from a marmoset model. | multiple sclerosis (ms) is thought to be initiated by the interaction of genetic and environmental factors, eliciting an autoimmune attack on the central nervous system. epstein-barr virus (ebv) is the strongest infectious risk factor, but an explanation for the paradox between high infection prevalence and low ms incidence remains elusive. we discuss new data using marmosets with experimental autoimmune encephalomyelitis (eae) - a valid primate model of ms. the findings may help to explain how ... | 2016 | 27836419 |
| prognostic correlations between abo blood group and pre-treatment plasma epstein-barr virus dna in patients with nasopharyngeal carcinoma receiving intensity-modulated radiotherapy. | the objective of this study is to assess the prognostic value of abo blood group in nasopharyngeal carcinoma (npc) treated by intensity-modulated radiotherapy (imrt). | 2016 | 27835689 |
| snhg8 is identified as a key regulator of epstein-barr virus(ebv)-associated gastric cancer by an integrative analysis of lncrna and mrna expression. | the epstein-barr virus (ebv) is associated with a variety of cancers, including gastric cancer, which has one of the highest mortality rates of all human cancers. long non-coding rnas (lncrnas) have been suggested to have important causal roles in gastric cancer. however, the interaction between lncrnas and ebv has not yet been studied. to this end, we sequenced 11,311 lncrnas and 144,826 protein-coding transcripts from four types of tissue: one non-ebv-infected gastric carcinoma (ebvngc) and it ... | 2016 | 27835598 |
| molecular detection of epstein - barr virus in nasopharyngeal carcinoma among sudanese population. | nasopharyngeal carcinoma (npc) is the most common cancer arising from the nasopharynx that varies significantly from other cancers of the head and neck in its occurrence, causes, clinical behavior, and treatment. npc caused by an interaction between infection with ebv and environmental and genetic factors, encompasses a multistep oncogenic process. the frequency of epstein-barr virus ebv among nasopharyngeal carcinoma is well known worldwide, however, in the sudan there is barely a published dat ... | 2016 | 27833652 |
| a possible link between the epstein-barr virus infection and autoimmune thyroid disorders. | the epstein-barr virus (ebv), also known as human herpesvirus 4, is a member of the herpesviridae virus family. ebv infection can cause infectious mononucleosis (im) in the lytic phase of ebv's life cycle. past ebv infection is associated with lymphomas, and may also result in certain allergic and autoimmune diseases. although potential mechanisms of autoimmune diseases have not been clearly elucidated, both genetic and environmental factors, such as infectious agents, are considered to be respo ... | 2016 | 27833448 |
| immune recovery and the risk of cmv/ ebv reactivation in children post allogeneic haematopoietic stem cell transplantation. | immune reconstitution was studied prospectively in 86 children who underwent allogeneic haematopoietic stem cell transplantation (hsct). we analysed the risk of cytomegalovirus (cmv) and epstein-barr virus (ebv) reactivation in correlation with the kinetics of immune recovery and in relation to other potential risk factors that may influence the reactivation of these viruses including: diagnosis, type of hsct, source of stem cells, type of conditioning, or the occurrence of graft-versus-host dis ... | 2016 | 27833447 |
| oncogenic role of tumor viruses in humans. | viruses are the intracellular pathogens that reproduce only in the living cell and manipulate the cellular machinery to produce more viruses. viral replications can affect cellular genes of the host in multiple cancerous ways. approximately, 20% of all human oncogenesis is caused by cancer-causing viruses known as oncoviruses. viral infection causes chronic inflammation leading to cell death, uncontrollable proliferation, and modulated expression of some of the regulatory proteins. oncogenesis i ... | 2017 | 27830995 |
| comprehensive polymerase chain reaction assay for detection of pathogenic dna in lymphoproliferative disorders of the ocular adnexa. | infectious agents have been identified as a major cause of specific types of human cancers worldwide. several microorganisms have been identified as potential aggravators of ocular adnexal neoplasms; however, given the rarity of these neoplasms, large epidemiological studies are difficult to coordinate. this study aimed to conduct an exhaustive search for pathogenic dna in lymphoproliferative disorders (lpd) of the ocular adnexa in a total of 70 patients who were diagnosed with lpd of the ocular ... | 2016 | 27830722 |
| achievement of disease control with donor-derived eb virus-specific cytotoxic t cells after allogeneic peripheral blood stem cell transplantation for aggressive nk-cell leukemia. | aggressive nk-cell leukemia (ankl) is characterized by systemic infiltration of epstein-barr virus (ebv)-associated natural killer cells and poor prognosis. we report a case of ankl in which ebv-specific cytotoxic t lymphocytes (ctls) were induced. a 41-year-old male suffered from fever, pancytopenia, and hepatosplenomegaly. the number of abnormal large granular lymphocytes in the bone marrow was increased and the cells were positive for cd56 and ebv-encoded small nuclear rnas. the patient was d ... | 2017 | 27830541 |
| tet2 functions as a resistance factor against dna methylation acquisition during epstein-barr virus infection. | extensive dna methylation is observed in gastric cancer with epstein-barr virus (ebv) infection, and ebv infection is the cause to induce this extensive hypermethylaton phenotype in gastric epithelial cells. however, some 5' regions of genes do not undergo de novo methylation, despite the induction of methylation in surrounding regions, suggesting the existence of a resistance factor against dna methylation acquisition. we conducted an rna-seq analysis of gastric epithelial cells with and withou ... | 2016 | 27829228 |
| letter to the editor: regarding "neurologic complications caused by epstein-barr virus in pediatric patients". | 2016 | 27827810 | |
| hydroa vacciniforme-like skin lesions in epstein-barr-virus-associated t-cell lymphoproliferation with subsequent development of aggressive nk/t-cell lymphoma. | is missing (short communication). | 2017 | 27826612 |
| epstein-barr virus: diseases linked to infection and transformation. | epstein-barr virus (ebv) was first discovered in 1964, and was the first known human tumor virus now shown to be associated with a vast number of human diseases. numerous studies have been conducted to understand infection, propagation, and transformation in various cell types linked to human diseases. however, a comprehensive lens through which virus infection, reactivation and transformation of infected host cells can be visualized is yet to be formally established and will need much further i ... | 2016 | 27826287 |
| the interaction between human papillomavirus and other viruses. | the etiological role of human papillomavirus (hpv) in anogenital tract and head and neck cancers is well established. however, only a low percentage of hpv-positive women develop cancer, indicating that hpv is necessary but not sufficient in carcinogenesis. several biological and environmental cofactors have been implicated in the development of hpv-associated carcinoma that include immune status, hormonal changes, parity, dietary habits, tobacco usage, and co-infection with other sexually trans ... | 2017 | 27826043 |
| the early diagnosis of testicular natural killer/t-cell lymphoma. | testicular natural killer/t-cell lymphoma is a rare aggressive extranodal lymphoma associated with epstein-barr virus infection. time to diagnose is crucial as the disease is rapidly progressive and fatal. early suspicion is documented by imaging studies and testicular biopsies which are key factors for diagnosing testicular natural killer/t-cell lymphoma. however, no reports have described the results of imaging studies. in this paper, contrast-enhanced ultrasonography (ceus), fluorine-18-fuoro ... | 2016 | 27824969 |
| plasmid-based generation of induced neural stem cells from adult human fibroblasts. | direct reprogramming from somatic to neural cell types has become an alternative to induced pluripotent stem cells. most protocols employ viral expression systems, posing the risk of random genomic integration. recent developments led to plasmid-based protocols, lowering this risk. however, these protocols either relied on continuous presence of a variety of small molecules or were only able to reprogram murine cells. we therefore established a reprogramming protocol based on vectors containing ... | 2016 | 27822179 |
| patterns of failure and survival in patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy in saudi arabia. | we aimed to investigate the patterns of failure (locoregional and distant metastasis), associated factors, and treatment outcomes in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy (imrt) combined with chemotherapy. | 2016 | 27822060 |
| transient reduction in iga(+) and igg(+) memory b cell numbers in young ebv-seropositive children: the generation r study. | the ebv is known to persist in memory b cells, but it remains unclear how this affects cell numbers and humoral immunity. we here studied ebv persistence in memory b cell subsets and consequences on b cell memory in young children. ebv genome loads were quantified in 6 memory b cell subsets in ebv(+) adults. the effects of ebv infection on memory b cell numbers and vaccination responses were studied longitudinally in children within the generation r population cohort between 14 mo and 6 yr of ag ... | 2017 | 27821468 |
| diagnostic challenges and clinical characteristics of hepatitis e virus-associated guillain-barré syndrome. | hepatitis e virus (hev) recently has been shown to be an antecedent infection in guillain-barré syndrome (gbs), but the clinical spectrum of hev-associated gbs is not yet documented, and diagnosing acute hev infection can be a challenge. | 2017 | 27820624 |
| high-throughput protein and mrna expression-based classification of gastric cancers can identify clinically distinct subtypes, concordant with recent molecular classifications. | gastric cancers have recently been classified into several types on the basis of molecular characterization, and the new taxonomy has shown to have clinical relevance. however, the technology required for thorough molecular classification is complicated and expensive, currently preventing widespread use. we aimed to reproduce the results of molecular classification using only simple techniques, that is, immunohistochemical analysis and in situ hybridization. we classified a cohort of 349 success ... | 2017 | 27819872 |
| tacrolimus plus sirolimus with or without atg as gvhd prophylaxis in hla-mismatched unrelated donor allogeneic stem cell transplantation. | hla-matched related or unrelated donors are not universally available. consequently, patients can be offered hematopoietic stem cell transplantation (hsct) from alternative donors, including mismatched unrelated donors (mmurd), known to cause a higher incidence of acute gvhd (agvhd) and chronic gvhd. in vivo t-cell-depletion strategies, such as antithymocyte globulin (atg) therapy, significantly decrease the risk of gvhd. we performed a multicenter, retrospective study comparing tacrolimus (tac) ... | 2017 | 27819684 |
| lmp1 signaling pathway activates irf4 in latent ebv infection and a positive circuit between pi3k and src is required. | interferon (ifn) regulatory factors (irfs) have crucial roles in immune regulation and oncogenesis. we have recently shown that irf4 is activated through c-src-mediated tyrosine phosphorylation in virus-transformed cells. however, the intracellular signaling pathway triggering src activation of irf4 remains unknown. in this study, we provide evidence that epstein-barr virus (ebv) latent membrane protein 1 (lmp1) promotes irf4 phosphorylation and markedly stimulates irf4 transcriptional activity, ... | 2016 | 27819673 |
| modulation of mir-185-5p expression by ebv-mir-bart6 contributes to developmental differences in abcg4 gene expression in human megakaryocytes. | immune thrombocytopenia (itp) is an acquired autoimmune disorder characterized by low platelet count and bleeding, and is usually triggered by viral infections. we previously reported that 14 viral micrornas of megakaryocytes cultured with serum from patients with itp, including ebv-mir-bart6, are up-regulated. previous research has reported that ebv-mir-bart6 down-regulated the expression of mir-185-5p. we therefore predicted that the abcg4 gene, which is highly expressed in megakaryocyte proge ... | 2016 | 27816548 |
| establishment and characterization of a novel hodgkin lymphoma cell line, am-hlh, carrying the epstein-barr virus genome integrated into the host chromosome. | we describe the establishment and characterization of a cell line, am-hlh, obtained from a patient with epstein-barr virus-positive (ebv(+) ) nodular sclerosis-type hodgkin lymphoma (hl). the cells were positive for cd2 and cd30 and negative for cd15. the immunoglobulin heavy- and κ light-chain genes were rearranged. the karyotype was of the triploid range. southern blotting using the ebv terminal repeat probe detected 3 hybridizing bands that were identical to those of the parental hl material. ... | 2016 | 27813134 |
| viral infections in juvenile myelomonocytic leukemia: prevalence and clinical implications. | viral infections may complicate the diagnosis of juvenile myelomonocytic leukemia (jmml) in a substantial proportion of patients, but this possibility has not been tested in a prospective study. the authors therefore measured the cellular expression of the mxa protein, a reliable marker of viral infection, at diagnosis in children with jmml to estimate the prevalence of such infections. | 2004 | 27811604 |
| programmed death-ligand 1 expression, microsatellite instability, epstein-barr virus, and human papillomavirus in nasopharyngeal carcinomas of patients from the philippines. | most nasopharyngeal carcinomas (npcs) in a high-incidence population are driven by epstein-barr virus (ebv) infection. ebv-associated malignancies have increased expression of the programmed death-ligand 1 (pd-l1). immunotherapy agents targeting the pd-1/pd-l1 pathway have achieved durable treatment effects in patients with various cancer types including ebv-associated malignancies. in this study, we sought to investigate pd-l1 expression in a cohort of patients with npcs from the philippines. f ... | 2016 | 27807760 |
| aggressive b-cell lymphomas: frequency, immunophenotype, and genetics in a reference laboratory population. | diffuse large b-cell lymphoma (dlbcl) is the most common type of lymphoma worldwide. the current world health organization classification includes several subtypes based on a combination of clinical, immunohistochemical, and genetic differences. other aggressive variants of b-cell lymphomas, including burkitt lymphoma and double-hit lymphomas are part of the differential diagnosis and often have overlapping features with dlbcl. in this study, we evaluated 760 of cases of dlbcl and other aggressi ... | 2016 | 27806850 |
| lymphoepithelioma-like carcinoma of breast-evaluation for epstein-barr virus-encoded rna, human papillomavirus, and markers of basal cell differentiation. | this is a largest series of 5 cases of lymphoepithelioma-like carcinoma (lec) of the breast attempting to look at the expression of basal cytokeratins (cks), human papillomavirus, and epstein-barr virus-encoded rnas in these tumors. five cases were selected after stringent evaluation of all breast carcinomas showing dense lymphoid infiltration. histologically, all these tumors showed the typical histology except 1 tumor that showed an unusual granulomatous response. all tumors were negative for ... | 2016 | 27806845 |
| pd-1-pd-l1 immune-checkpoint blockade in b-cell lymphomas. | cancer cells can escape t-cell-mediated cellular cytotoxicity by exploiting the inhibitory programmed cell-death protein 1 (pd-1)/programmed cell death 1 ligand 1 (pd-l1) immune checkpoint. indeed, therapeutic antibodies that block the pd-1-pd-l1 axis induce durable clinical responses against a growing list of solid tumours. b-cell lymphomas also leverage this checkpoint to escape immune recognition, although the outcomes of pd-1-pd-l1 blockade, and the correlations between pd-l1 expression and ... | 2017 | 27805626 |
| posttransplant lymphoproliferative disorder manifesting as intestinal epstein-barr virus-positive anaplastic large-cell lymphoma in an adult renal transplant recipient. | posttransplant lymphoproliferative disorder is a relatively common posttransplant malignancy affecting as many as 10% of all solid-organ recipients. most cases of posttransplant lymphoproliferative disorder are of b-cell origin, with common epstein-barr virus association. posttransplant lymphoproliferative disorders of t-cell origin are much rarer and less frequently associated with epstein-barr virus. here, we report an unusual case of epstein-barr virus-positive anaplastic large-cell lymphoma ... | 2016 | 27805515 |
| the third signal cytokine interleukin 12 rather than immune checkpoint inhibitors contributes to the functional restoration of hepatitis d virus-specific t cells. | hepatitis d virus (hdv) infection affects 15-20 million individuals worldwide and causes severely progressive hepatitis. it is unknown to what extent cellular immune responses contribute to liver disease and control of viral replication in hdv infection. | 2017 | 27803174 |
| [molecular tests in diagnosis of cytomegalovirus (cmv), human herpesvirus 6 (hhv-6) and epstein-barr virus (ebv) using real-time pcr in hiv positive and hiv-negative pregnant women in ouagadougou, burkina faso]. | herpesvirus ebv, cmv and hhv-6 are viruses that evolve based on pandemic modeling and are responsible for congenital infections causing severe sequelae in infants. this study aims to determine the prevalence of cmv, ebv and hhv-6 among hiv (+) and hiv (-) pregnant women in ouagadougou. | 2016 | 27800078 |
| protein stabilization improves stat3 function in autosomal dominant hyper-ige syndrome. | autosomal dominant hyper-ige syndrome (ad-hies) is caused by dominant-negative mutations in stat3; however, the molecular basis for mutant stat3 allele dysfunction is unclear and treatment remains supportive. we hypothesized that ad-hies mutations decrease stat3 protein stability and that mutant stat3 activity can be improved by agents that increase chaperone protein activity. we used computer modeling to characterize the effect of stat3 mutations on protein stability. we measured stat3 protein ... | 2016 | 27799162 |
| what is that rash? | a healthy 15-month-old girl presented to the emergency department with a 24-hour history of fever and rash. the initial blanching rash developed into non-blanching areas with associated leg swelling. she had received no recent medications, had no known drug allergies and no unwell contacts.on examination, she was feverish at 38.6°c, capillary refill time was <2 s with warm peripheries, heart rate 169 bpm and blood pressure 94/59 mm hg. a palpable purpuric rash was evident on all four limbs and f ... | 2018 | 27799151 |
| viral-associated gn: hepatitis b and other viral infections. | by definition, viral-associated gn indicates the direct pathogenic relationship between active viral replication and the development of acute gn. this definition is in sharp contrast to the semantic label and pathophysiologic foundation behind postinfectious gn that uniquely develops only during a period of resolved and absent active infection. the primary example of postinfectious gn are the glomerular lesions described after a pharyngeal or cutaneous streptococcal infection and do not represen ... | 2016 | 27797900 |
| association of epstein-barr virus reactivation with the recovery of cd4/cd8 double-negative t lymphocytes after haploidentical hematopoietic stem cell transplantation. | ebv infection is one of the life-threatening clinical complications in patients who underwent haploidentical hematopoietic stem cell transplantation (haplohsct). although immune recovery is recognized to be crucial for decreasing subsequent morbidity of infections, the link between t-cell recovery and ebv infection after haplohsct remains elusive. we recently compared the influences of different doses of antithymocyte globulin conditioning on the t-cell reconstitution post haplohsct and suggeste ... | 2017 | 27797369 |
| epstein-barr virus (ebv)-bamhi-a rightward transcript (bart)-6 and cellular microrna-142 synergistically compromise immune defense of host cells in ebv-positive burkitt lymphoma. | background this study was designed to explore the molecular mechanism underlying the effect of cellular mirnas and ebv mirna upon the expression of targets such as pten, and their involvement in the pathogenesis of burkitt lymphoma. material and methods in this study, we examined several differentially expressed cellular mirnas in ebv-positive versus ebv-negative burkett lymphoma tissue samples, and confirmed pten as targets of cellular mir-142 by using a bioinformatics tool, luciferase reporter ... | 2016 | 27796281 |
| epstein-barr virus infection and related hematological diseases. | once the epstein-barr virus (ebv) has infected a person, it then latently infects b cells. this latent infection lasts a lifetime. however, ebv can infect t or nk cells (t/nk cells) in rare cases. therefore, ebv causes various hematological diseases. among these diseases, caebv is regarded as the most problematic because, although it is not particularly uncommon, the diagnostic tests for this disease are not covered by health insurance, a serious illness in the "non-active" periods is lacking, a ... | 2017 | 27795539 |
| the long and complicated relationship between epstein-barr virus and epithelial cells. | the roles of epithelial cells in infection and persistence of the epstein-barr virus (ebv) have long been difficult to resolve. however, recent developments have reinforced the conclusion that these cells are a major site of virus replication and raised the possibility that, like papillomaviruses, ebv has evolved to take advantage of epithelial differentiation to ensure survival, persistence, and spread. | 2017 | 27795426 |
| infectious burden and semen parameters. | to investigate the relationship between chronic infections detected in serum and semen quality. the pathogen burden is a concept consisting in the observation that, in patients with heart disease, damaging effects of the coronary arteries increase concomitantly with the number of agents responsible for chronic infections to which patients mounted a serological response. previous observations that helicobacter pylori infection may reduce the semen quality prompted us to perform the present study. | 2017 | 27793655 |
| spontaneous metastases in immunocompetent mice harboring a primary tumor driven by oncogene latent membrane protein 1 from epstein-barr virus. | in vitro and clinical studies suggest that the oncogene lmp1 (latent membrane protein 1) encoded by epstein-barr virus (ebv) plays a role in the development of nasopharyngeal carcinoma (npc) and the formation of metastases in immunocompetent individuals. however, whether lmp1 itself is sufficient to drive these events in immunocompetent hosts remains elusive due to the lack of appropriate experimental models. the aim of this study was to study lmp1-dependent tumorigenesis and metastasis in balb/ ... | 2016 | 27793268 |
| perturbing purinergic signaling: a pathogen's guidebook to counteracting inflammatory responses. | in this issue of the biomedical journal, we learn how bacteria and parasites alike counteract inflammatory signaling by manipulating purinergic signaling. we also focus on an original article shedding light on the role of an epstein-barr virus encoded gene in metastasis in nasopharyngeal carcinoma. finally, we learn about a possible link between trichomonas vaginalis and recurrent urinary tract infection. | 2016 | 27793264 |
| acute pancreatitis associated with everolimus after kidney transplantation: a case report. | acute pancreatitis (ap) following kt is a rare and often fatal complication of the early post-transplant period. common causative factors for ap are rare after kt; anti-rejection drugs as cya, prednisone and mmf have been implicated, although evidence is not strong and we found no reports on possible causative role for mtor inhibitors. | 2016 | 27793122 |
| aqueous humor polymerase chain reaction in uveitis - utility and safety. | to study the value and safety of aqueous humor polymerase chain reaction (pcr) analysis for herpes simplex, varicella zoster, cytomegalovirus, epstein-barr virus and toxoplasma gondii in patients with uveitis. | 2016 | 27793120 |
| a case of epstein-barr virus-associated hemophagocytic lymphohistiocytosis with severe cardiac complications. | hemophagocytic lymphohistiocytosis (hlh) is a life threatening hematological disorder associated with severe systemic inflammation caused by an uncontrolled and ineffective immune response resulting in cytokine storm. epstein-barr virus (ebv) is the most common infectious agent in patients with the viral-associated hlh. limited numbers of cases with cardiac complication have been demonstrated in other viral-associated hlh patients. herein, we report a pediatric case of severe ebv-associated hlh ... | 2016 | 27793118 |
| epstein-barr virus latent membrane protein 2a (lmp2a) enhances il-10 production through the activation of bruton's tyrosine kinase and stat3. | previous data demonstrate that epstein-barr virus latent membrane protein 2a (lmp2a) enhances il-10 to promote the survival of lmp2a-expressing b cell lymphomas. since stat3 is an important regulator of il-10 production, we hypothesized that lmp2a activates a signal transduction cascade that increases stat3 phosphorylation to enhance il-10. using lmp2a-negative and -positive b cell lines, the data indicate that lmp2a requires the early signaling molecules of the syk/ras/pi3k pathway to increase ... | 2017 | 27792904 |
| epstein-barr virus-positive diffuse large b-cell lymphoma involving the colon in a patient with ulcerative pancolitis and polymyositis on long-term methotrexate therapy. | the link between immunosuppressive therapy and increased lymphoma risk is well established in patients with solid organ transplantation. epstein-barr virus-positive (ebv) diffuse large b-cell lymphoma (dlbcl) is known to be a complication in patients receiving methotrexate for rheumatoid arthritis, and the risk of lymphoma in inflammatory bowel disease (ibd) has raised concerns regarding the lymphoproliferative potential of immunomodulatory therapy. in this report, we describe a case of ebv-posi ... | 2016 | 27785332 |
| epstein-barr virus-associated acute liver failure present in a 67-year-old immunocompetent female. | acute liver failure (alf) is a rare illness with a high mortality rate. the only favorable management is emergent liver transplantation. about 13% of alf cases have no clear etiology. epstein-barr virus (ebv)-associated alf accounts for less than 1% of all alf cases, and is seen mostly in adults younger than 40 years. there are only a few cases of ebv-associated alf in elderly immunocompromised adults. we report a case of alf in an immunocompetent 67-year-old woman caused by ebv infection that w ... | 2016 | 27785330 |
| [a case of chronic active epstein-barr virus infection with concomitant giant coronary artery aneurysm]. | 2016 | 27784484 | |
| [infection status and prognosis analysis of epstein-barr virus in patients with newly diagnosed hodgkin's lymphoma]. | to investigate the epstein barr virus(ebv) positive rate in newly diagnosed hodgkin's lymphoma(hl) and the prognostic significance of ebv status. | 2016 | 27784366 |
| pediatric small bowel transplantation: a single-center experience from turkey. | small bowel transplantation (sbtx) is a treatment option for patients with serious parenteral nutrition-related problems in intestinal failure. izmir tepecik training research hospital organ transplantation center is still the only pediatric intestinal transplant center in turkey. | 2016 | 27782890 |
| cytotoxic epstein-barr virus-positive large b cell lymphoma: a regulatory b cell-derived neoplasia? | a new subtype of granzyme b (grb)-producing regulatory b cells (bregs ) has been described recently; these peculiar cytotoxic b cells are increased significantly in interleukin (il)-21-rich settings, and in particular during hiv and epstein-barr virus (ebv) infection. our aim is to report a unique case of an ebv-positive diffuse large b cell lymphoma (dlbcl) with cytotoxic features arisen in an hiv(+) patient, and to understand if this lesion may represent a proliferation of neoplastic cytotoxic ... | 2017 | 27782313 |
| clinical presentation and outcome of pediatric patients with hemophagocytic lymphohistiocytosis in china: a retrospective multicenter study. | hemophagocytic lymphohistiocytosis (hlh) is a heterogeneous disease with major diagnostic and therapeutic difficulties. a large-scale multicenter study of pediatric hlh is still lacking in china. | 2017 | 27781387 |
| hodgkin lymphoma, hiv, and epstein-barr virus in malawi: longitudinal results from the kamuzu central hospital lymphoma study. | contemporary descriptions of classical hodgkin lymphoma (chl) are lacking from sub-saharan africa where human immunodeficiency virus (hiv) and epstein-barr virus (ebv) are prevalent. | 2017 | 27781380 |
| extranodal nk/t cell lymphoma, nasal type (enktl-nt): an update on epidemiology, clinical presentation, and natural history in north american and european cases. | extranodal nk/t cell lymphoma, nasal type (enktl-nt) is an aggressive extranodal non-hodgkin lymphoma most commonly occurring in east asia and latin america but with increasing incidence in the united states. data on epidemiology, disease presentation, and outcome for european and north american ("western") cases are very limited. we review published landmark clinical studies on enktl-nt in the west and report in detail recent data, including our institutional experience. | 2016 | 27778143 |
| clinicopathological characteristics and genomic profile of primary sinonasal tract diffuse large b cell lymphoma (dlbcl) reveals gain at 1q31 and rgs1 encoding protein; high rgs1 immunohistochemical expression associates with poor overall survival in dlbcl not otherwise specified (nos). | we aimed to define the clinicopathological characteristics of 29 primary sinonasal diffuse large b cell lymphoma (dlbcl(sn) ) in a series of 240 cases of dlbcl not otherwise specified [dlbcl(all ()(nos)()) ], including dlbcl(sn) training set (n = 11) and validation set (n = 18), and dlbcl(non-sn) (n = 211). | 2017 | 27775850 |
| prevalence of human papillomavirus, epstein-barr virus, and cytomegalovirus in fine needle aspirates from lung carcinoma: a case-control study with review of literature. | oncogenic viruses have recently been allied with lung carcinoma, however, the causal association has not been established till date. the study was conducted to determine the prevalence of high-risk human papillomavirus (hpv; subtypes 16, 18, 31, 33 and 45), epstein-barr virus (ebv) and cytomegalovirus (cmv) in lung carcinoma using polymerase chain reaction (pcr) on fine needle aspirates. | 2016 | 27774746 |
| oncogenic γ herpesviruses ebv and hhv8 in kidney transplantation. | epstein-barr virus (ebv) and human herpesvirus-8 (hhv-8) are γ herpesviruses associated with post-transplant malignancies in kidney transplant recipients. ebv is associated with post-transplantation lymphoproliferative disorder (ptld), with increased risk in ebv-seronegative patients on intensified immunosuppression. human herpesvirus-8 is associated with kaposi's sarcoma (ks), with an increased risk in certain patient populations. diagnosis of ptld and ks relies on tissue biopsy. the mainstay o ... | 2016 | 27772621 |