Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| analysis of dna topology of ebv minichromosomes in hek 293 cells. | simian virus 40 (sv40) and epstein-barr virus (ebv) are frequently used as model systems to study dna replication. their genomes are both circular duplex dnas organized in a single replicon where replication initiates at a precise site upon binding of a specific protein: the large tumor (t) antigen for sv40 and the epstein-barr nuclear antigen 1 (ebna-1) for ebv. despite the abundant information available on the genetics and biochemistry of the replication process in these systems, little is kno ... | 2017 | 29186176 |
| pediatric pulmonary epstein-barr virus-positive diffuse large b-cell lymphoma: a case report and review of the literature. | non-hodgkin's lymphoma (nhl) is a common malignancy of childhood; however, a lung primary presentation is an uncommon finding, as is finding an association with the epstein-barr virus (ebv). we report the case of a 23-month-old female who developed ebv-associated diffuse large b-cell lymphoma (dlbcl) that was initially thought to be pneumonia. extensive tissue necrosis, focal angioinvasion, and angiodestruction were observed. she was refractory to various therapy regimens, subsequently developed ... | 2017 | 29119031 |
| characterization of an anti-fetal achr monoclonal antibody isolated from a myasthenia gravis patient. | we report here the sequence and functional characterization of a recombinantly expressed autoantibody (mab 131) previously isolated from a myasthenia gravis patient by immortalization of thymic b cells using epstein-barr virus and tlr9 activation. the antibody is characterized by a high degree of somatic mutations as well as a 6 amino acid insertion within the vhcdr2. the recombinant mab 131 is specific for the γ-subunit of the fetal achr to which it bound with sub-nanomolar apparent affinity, a ... | 2017 | 29089519 |
| actionable gene-based classification toward precision medicine in gastric cancer. | intertumoral heterogeneity represents a significant hurdle to identifying optimized targeted therapies in gastric cancer (gc). to realize precision medicine for gc patients, an actionable gene alteration-based molecular classification that directly associates gcs with targeted therapies is needed. | 2017 | 29089060 |
| clinical and pathological characterization of epstein-barr virus-associated gastric carcinomas in portugal. | to determine the prevalence of epstein-barr virus (ebv)-associated gastric carcinomas in the north region of portugal and to study its clinicopathological characteristics. | 2017 | 29142476 |
| the epstein-barr virus episome maneuvers between nuclear chromatin compartments during reactivation. | the human genome is structurally organized in three-dimensional space to facilitate functional partitioning of transcription. we learned that the latent episome of the human epstein-barr virus (ebv) preferentially associates with gene-poor chromosomes and avoids gene-rich chromosomes. kaposi's sarcoma-associated herpesvirus behaves similarly, but human papillomavirus does not. contacts localize on the ebv side to orip, the latent origin of replication. this genetic element, and the ebna1 protein ... | 2017 | 29142137 |
| immune activation and benefit from avelumab in ebv-positive gastric cancer. | response to immune checkpoint therapy can be associated with a high mutation burden, but other mechanisms are also likely to be important. we identified a patient with metastatic gastric cancer with meaningful clinical benefit from treatment with the anti-programmed death-ligand 1 (pd-l1) antibody avelumab. this tumor showed no evidence of high mutation burden or mismatch repair defect but was strongly positive for presence of epstein-barr virus (ebv) encoded rna. analysis of the cancer genome a ... | 2017 | 29155997 |
| a rare localised nasal cd30+ primary cutaneous t-cell lymphoma following liver transplantation. | cutaneous t-cell post-transplant lymphoproliferative disorder (ptld) is a rare clinical presentation that can potentially turn aggressive in solid-organ transplant recipients if not detected and intervened on early. we encountered a rare case of rapidly worsening primary cutaneous cd30-positive, epstein-barr virus-negative anaplastic large cell lymphoma (alcl) of t-cell origin, manifesting as an isolated nasal tip lesion in a 71-year-old man 4 years after orthotopic liver transplantation. excisi ... | 2017 | 29103006 |
| early disseminated lyme disease masquerading as mononucleosis: a case report. | disseminated lyme disease can be difficult to diagnose, as it begins with nonspecific signs and symptoms, which, if not treated correctly, can lead to atrioventricular conduction blocks and meningitis. in addition, the diagnosis can be further complicated by potentially false-positive test results. | 2017 | 29102094 |
| how immunologic and genetic biomarkers impact hodgkin lymphoma classification, diagnosis, and management: a huge potential that yet needs to be exploited. | "ne è passata di acqua sotto i ponti." it has been a long time since the diagnosis of hodgkin lymphoma (hl) was exclusively based on the detection of typical reed-sternberg cells and the recognition of the characteristic morpho-histological background, as well as on the pathologist's skill. the discovery of immunologic, molecular genetic and virologic biomarkers has provided an objective contribution to the diagnosis and a scientific basis for a modern classification of hl. recent updates have c ... | 2017 | 29099538 |
| hodgkin's lymphoma arising in a case of mycosis fungoides: an unusual association. | mycosis fungoides is a cutaneous t-cell lymphoma with a high risk for developing secondary malignancies, especially b-cell lymphoproliferative disorders. about 40 cases of hodgkin's lymphoma associated with mycosis fungoides have been reported in literature till date. we report a case of a 35-year-old gentleman who presented with intensely itchy reddish lesions all over the body. multiple skin biopsies taken from the lesions on scalp and back confirmed the clinical diagnosis of mycosis fungoides ... | 2017 | 29098990 |
| identification of epstein-barr virus in the human placenta and its pathologic characteristics. | epstein-barr virus (ebv), a common pathogen in humans, is suspected as the cause of multiple pregnancy-related pathologies including depression, preeclampsia, and stillbirth. moreover, transmission of ebv through the placenta has been reported. however, the focus of ebv infection within the placenta has remained unknown to date. in this study, we proved the expression of latent ebv genes in the endometrial glandular epithelial cells of the placenta and investigated the cytological characteristic ... | 2017 | 29115077 |
| epstein-barr virus dna load kinetics analysis in allogeneic hematopoietic stem cell transplant recipients: is it of any clinical usefulness? | there is a lack of clinical information regarding the usefulness of plasma epstein-barr virus (ebv) dna load kinetics analyses in the management of ebv infections in allogeneic hematopoietic stem cell transplantation (allo-hsct) recipients. namely, it remains unknown whether this type of analysis can help physicians to anticipate the development of high-level ebv dnaemia episodes requiring rituximab treatment or predict the risk of recurrent ebv dnaemia or post-transplant lymphoproliferative dis ... | 2017 | 29096390 |
| age-related macular degeneration: a connection between human herpes virus-6a-induced cd46 downregulation and complement activation? | viruses are able to interfere with the immune system by docking to receptors on host cells that are important for proper functioning of the immune system. a well-known example is the human immunodeficiency virus that uses cd4 cell surface molecules to enter host lymphocytes and thereby deleteriously destroying the helper cell population of the immune system. a more complicated mechanism is seen in multiple sclerosis (ms) where human herpes virus-6a (hhv-6a) infects astrocytes by docking to the c ... | 2017 | 29093709 |
| epstein-barr virus brlf1 induces genomic instability and progressive malignancy in nasopharyngeal carcinoma cells. | nasopharyngeal carcinoma (npc) is a serious health problem in china and southeast asia. relapse is the major cause of mortality, but mechanisms of relapse are mysterious. epstein-barr virus (ebv) reactivation and host genomic instability (gi) have correlated with npc development. previously, we reported that lytic early genes dnase and balf3 induce genetic alterations and progressive malignancy in npc cells, implying lytic proteins may be required for npc relapse. in this study, we show that imm ... | 2017 | 29108278 |
| lymphoproliferative disorders with concurrent hhv8 and ebv infection: beyond primary effusion lymphoma and germinotropic lymphoproliferative disorder. | lymphoproliferative disorders (lpd) characterised by human herpesvirus 8 (hhv8) and epstein-barr virus (ebv) infection are rare and two entities are included in the world health organisation classification: primary effusion lymphoma (pel) and germinotropic lpd. these two entities have very different clinicopathological presentations and prognosis. here we describe two cases of hhv8-positive, ebv-positive lymphoma with clinicopathological features that are not consistent with either pel or germin ... | 2017 | 29105119 |
| pathogenic role of exosomes in epstein-barr virus (ebv)-associated cancers. | exosomes are 40- to 100-nm membrane-bound small vesicles that carry a great variety of cellular cargoes including proteins, dna, messenger rnas (mrnas), and micrornas (mirnas). these nanovesicles are detected in various biological fluids such as serum, urine, saliva, and seminal fluids. exosomes serve as key mediators in intercellular communication by facilitating the transfer and exchange of cellular components from cells to cells. they contain various pathogenic factors whereby their adverse e ... | 2017 | 29104494 |
| association between epstein barr virus and tongue squamous cell carcinoma in iranian patients. | detection of epstein-barr virus in oral squamous cell carcinoma suggests its involvement in the carcinogenesis of oral cavity. but, there are few studies on the incidence of ebv genome in squamous cell carcinomas at specific locations in the oral cavity like tongue and with different tumor progression. in this study the presence of ebv genome in tongue squamous cell carcinoma (tscc) in iranian patients were investigated. accordingly, a total of 94 cases with tscc were firstly analyzed for the pr ... | 2017 | 29103768 |
| the conundrum of the epstein-barr virus-associated gastric carcinoma in the americas. | epstein-barr virus-associated gastric carcinoma shows a higher prevalence in the americas than asia. we summarize all studies of epstein barr virus-associated gastric carcinoma in the americas, focusing on host characteristics, environmental associations and phylogeographic diversity of epstein-barr virus strains. in the americas, the prevalence of epstein barr virus-associated gastric carcinoma is 11.4%, more frequent in males and portray predominantly diffuse-type histology. ebers, ebnas, bart ... | 2017 | 29088902 |
| irak4 is essential for tlr9-induced suppression of epstein-barr virus bzlf1 transcription in akata burkitt's lymphoma cells. | burkitt's lymphoma (bl) is the most common childhood cancer in equatorial africa, and is endemic to areas where people are chronically co-infected with epstein-barr virus (ebv) and the malaria pathogen plasmodium falciparum. the contribution of these pathogens in the oncogenic process remains poorly understood. we showed earlier that the activation of toll-like receptor (tlr) 9 by hemozoin, a disposal product formed from the digestion of blood by p. falciparum, suppresses the lytic reactivation ... | 2017 | 29088270 |
| epstein-barr virus-positive mucocutaneous ulcer in a patient with polycythemia vera treated with oral hydroxyurea. | 2017 | 29139148 | |
| correction for ansari et al., "constitutive interferon-inducible protein 16-inflammasome activation during epstein-barr virus latency i, ii, and iii in b and epithelial cells". | 2017 | 29138330 | |
| single nucleotide polymorphism rs2274084 of gap junction protein beta 2 gene among epstein-barr virus-associated tumors. | gap junction protein beta 2 gene (gjb2) encodes one of connexins- connexin 26 (cx26), which mainly expressed in epithelial cells. cx26 is usually considered a channel to exchange information between cells, which plays a critical role in tumor cell proliferation. | 2017 | 29103018 |
| [advances on epstein-barr virus related post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation]. | 2017 | 29081206 | |
| [clinical features of mononucleosis because of epstein-barr virus and cytomegalovirus co-infection in adult patients]. | objective: to identify the clinical features of mononucleosis caused by co-infection of epstein-barr virus (ebv) and cytomegalovirus (cmv) in adult patients. methods: a total of 103 inpatients with mononucleosis in peking university third hospital from may 2013 to may 2016 were collected as the study subjects.the patients were divided into three groups according to the responsible pathogens: 33 patients infected with ebv and cmv, 53 infected with ebv alone and 17 infected with cmv alone.furtherm ... | 2017 | 29081150 |
| cytokines associated with burkitt's lymphoma in western kenya. | burkitt's lymphoma (bl) is a common aggressive non-hodgkin's lymphoma in east and central africa among children. persistent infections with epstein barr virus or plasmodium falciparum are associated with immune hyperstimulation. it is hypothesised that inadvertent cytokine responses to infections indirectly or directly influence b cell neoplastic transformation through c-myelocytomatosis (c-myc) gene translocation. we sought to describe cytokines in children and adolescents with bl. participants ... | 2017 | 29078819 |
| is epstein-barr virus infection associated with the pathogenesis of microscopic colitis? | epstein-barr virus (ebv) has been associated with inflammation in the colon, particularly in patients with inflammatory bowel disease (ibd). even if a relevant plasmocytosis, similar to ibd, is present in microscopic colitis (mc), the frequency of ebv infection in this setting is unknown. | 2017 | 29078077 |
| 18f-fdg pet for detection of primary tracheobronchial t-/natural killer-cell-derived posttransplant lymphoproliferative disorder after lung transplantation. | posttransplant lymphoproliferative disorder (ptld) is a rare, but potentially devastating complication of solid organ transplantation. epstein-barr virus-associated ptlds of t-cell origin are exceedingly rare. we present the case of a 20-year-old man with extranasal t-/natural killer-cell-derived ptld after lung transplantation who underwent an f-fdg pet/ct scan for staging of disease. the f-fdg-pet scan demonstrated an unusual pattern of lymphomatous involvement limited to the recipients trache ... | 2017 | 29076909 |
| multiple oncogenic viruses are present in human breast tissues before development of virus associated breast cancer. | multiple oncogenic viruses including, mouse mammary tumor virus, bovine leukemia virus, human papilloma virus, and epstein barr virus, have been identified as separate infectious pathogens in human breast cancer. here we demonstrate that these four viruses may be present in normal and benign breast tissues 1 to 11 years before the development of same virus breast cancer in the same patients. | 2017 | 29075317 |
| serology of viral infections and tuberculosis screening in an ibd population referred to a tertiary centre of southern italy. | with the introduction of more potent immunosuppressive agents in inflammatory bowel disease, prevention of opportunistic infections has become necessary by introducing screening programs. prevalence of the most important infectious agents may vary in different geographical areas. the aim of our study was to assess the immune status for hepatitis b, varicella, mononucleosis, and cytomegalovirus infection together with the determination of the hepatitis c and tuberculosis status in southern italy. | 2017 | 29075289 |
| protective effect of rituximab in chronic graft-versus-host disease occurrence in allogeneic transplant patients with epstein barr virus viremia. | b cells are involved in chronic graft-versus-host disease (cgvhd) pathogenesis, and rituximab may have a therapeutic effect on cgvhd in allogeneic hematopoietic stem cell transplantation (allo-hsct) patients. herein, we retrospectively evaluated the prophylactic effect of rituximab on cgvhd in a group of chinese allo-hsct patients. a total of 102 patients, who suffered epstein barr virus (ebv) viremia within 100 days after allo-hsct, were included in this study. fifty patients received rituximab ... | 2017 | 29075063 |
| ebv latent membrane protein 2a orchestrates p27kip1 degradation via cks1 to accelerate myc-driven lymphoma in mice. | epstein-barr virus (ebv) establishes lifelong infection in b lymphocytes of most human hosts and is associated with several b lymphomas. during latent infection, ebv encodes latent membrane protein 2a (lmp2a) to promote the survival of b cells by mimicking host b-cell receptor signaling. by studying the roles of lmp2a during lymphoma development in vivo, we found that lmp2a mediates rapid myc-driven lymphoma onset by allowing b cells to bypass myc-induced apoptosis mediated by the p53 pathway in ... | 2017 | 29074502 |
| intratumoural pd-l1 expression is associated with worse survival of patients with epstein-barr virus-associated gastric cancer. | this study investigated the clinical relevance and prognostic impact of the overall expression of programmed cell death protein ligand-1 (pd-l1) and programmed cell death protein ligand-2 (pd-l2), in patients with epstein-barr virus-associated gastric cancer (ebvagc). | 2017 | 29073638 |
| the epstein-barr virus b-zip protein zta recognizes specific dna sequences containing 5-methylcytosine and 5-hydroxymethylcytosine. | the epstein-barr virus (ebv) b-zip transcription factor zta binds to many dna sequences containing methylated cg dinucleotides. using protein binding microarrays (pbms), we analyzed the sequence specific dna binding of zta to four kinds of double-stranded dna (dsdna): (1) dna containing cytosine in both strands, (2) dna with 5-methylcytosine (5mc) in one strand and cytosine in the second strand, (3) dna with 5-hydroxymethylcytosine (5hmc) in one strand and cytosine in the second strand, and (4) ... | 2017 | 29072898 |
| the perivascular microenvironment in epstein-barr virus positive primary central nervous system lymphoma: the role of programmed cell death 1 and programmed cell death ligand 1. | it has been shown that high expression of certain immune checkpoint molecules, including those of the programmed death protein 1/programmed death ligand 1 (pd-1/pd-l1) axis, can be utilized to regulate immunosuppression in the microenvironment of malignant neoplasms. for the purpose of clarifying the immune-escape mechanism of primary central nervous system lymphomas (pcnsls), particularly in epstein-barr virus (ebv)-positive cases, markers for pd-1, pd-l1, tumor-associated macrophages (tams), a ... | 2017 | 29067721 |
| iatrogenic solid tumors following immunosuppressive therapy. | immunosuppression induced by chronic medication, such as occurs post-transplantation, may increase a patient's risk of developing solid tumors. these are often rare tumors characterized by odd presentations. this review focuses on commonly encountered iatrogenic, non-hematopoietic solid tumors following immunotherapy and provides a practical approach to their diagnosis. all of the malignancies covered in this review are viral-induced. they include human papillomavirus (hpv)-associated carcinomas ... | 2017 | 29066044 |
| risk factors and clinical outcomes of pediatric liver transplant recipients with post-transplant lymphoproliferative disease in a multi-ethnic asian cohort. | we aimed to evaluate clinical characteristics, risk factors, and disease outcomes for liver transplant recipients (ltr) with post-transplant lymphoproliferative disease (ptld) at our center. | 2017 | 29071779 |
| two cases of angioimmunoblastic t-cell lymphoma with concomitant positive serology for acute epstein-barr virus infection. | 2017 | 29071053 | |
| managing epstein-barr virus and other risk factors in ms-future perspectives. | here, we discuss the rationale and feasibility of treatment directed against the modifiable risk factors in multiple sclerosis. the established environmental risk factors vitamin d insufficiency, cigarette smoke exposure, adolescence overweight, and epstein-barr virus infection are reviewed. already available measures to target these risk factors are discussed. | 2017 | 29068493 |
| is the hygiene hypothesis relevant for the risk of multiple sclerosis? | the hygiene hypothesis, suggesting that low exposure to pathogens early in life can increase the risk for immune-mediated diseases, has been proposed as an explanation for the increase in incidence of allergy and autoimmune diseases in industrialized countries during the last decades. several aspects of the hygiene hypothesis have been related to ms. already in 1966, the risk of ms was suggested to be higher in individuals with high hygienic standard during childhood. further, an episode of infe ... | 2017 | 29068485 |
| impact of antiviral prophylaxis in adults epstein-barr virus-seronegative kidney recipients on early and late post-transplantation lymphoproliferative disorder onset: a retrospective cohort study. | post-transplantation lymphoproliferative disorder (ptld) pathogenesis is related to ebv infection. mismatch with the donor (ebv d+/r-) is the main risk factor for both early ptld (<1 year post-transplantation) and late (>1 year). in these at-risk patients, the role of antiviral prophylaxis for preventing ptld remains controversial. we analyzed the impact of antiviral drugs given to prevent cmv disease in a monocentric retrospective cohort of 73 adult kidney or kidney-pancreas ebv-seronegative re ... | 2017 | 29057508 |
| a phase ii study of methotrexate, etoposide, dexamethasone and pegaspargase sandwiched with radiotherapy in the treatment of newly diagnosed, stage ie to iie extranodal natural-killer/t-cell lymphoma, nasal-type. | a phase ii study of methotrexate, etoposide, dexamethasone, and pegaspargase (mesa) sandwiched with radiotherapy for newly diagnosed, stage ie-iie extranodal natural-killer/t-cell lymphoma, nasal-type (enktl) was conducted to explore its clinical efficacy and safety, as well as novel serum biomarkers upon anti-metabolic treatment. | 2017 | 29056540 |
| prognostic significance of standardized uptake value on f18-fdg pet/ct in patients with extranodal nasal type nk/t cell lymphoma: a multicenter, retrospective analysis. | the purpose of this study was to evaluate the value of parameters assessed with f18-flurodeoxyglucose (fdg) positron emission tomography/computed tomography (pet/ct) in predicting relapse free survival and overall survival in patients with extranodal nasal type nk/t cell lymphoma. | 2017 | 29056243 |
| evaluation of pd1/pdl1 expression and their clinicopathologic association in ebv-associated lymphoproliferative disorders in nonimmunosuppressed patients. | epstein-barr virus (ebv)-associated lymphoproliferative disorders (lpd)/lymphomas in nonimmunosuppressed patients represent a unique entity and have been proposed to be related to immune senescence. engagement of programmed cell death 1 (pd1) by its ligand programmed death ligand 1 (pdl1) inhibits t-cell activation, and leads to t-cell exhaustion. in clinical trials, therapeutic antibodies that block the pd1-pdl1 axis have shown promising therapeutic activity in certain types of lymphomas. altho ... | 2017 | 29084057 |
| adenovirus-associated acute appendicitis: an under-recognized relationship? | acute appendicitis (aa) is one of the most common causes of a surgical abdomen worldwide, occurring most frequently in those age 10 to 29 years. adenovirus (adv) is a rare but reported cause of aa in children and a well-recognized cause of intussusception in infants and young children. annually, about 36,000 basic military trainees (bmts) undergo initial training at joint base san antonio lackland, texas. before reintroduction of the adv 4/7 vaccine in november 2011, one-third of bmts developed ... | 2017 | 29087922 |
| primary central nervous system extranodal nasal-type natural killer/t-cell lymphoma with cd20 expression. | we report a unique case of primary cns extranodal natural killer/t-cell lymphoma (pcns enktcl) with cd20 expression and the monoclonal rearrangement of ig heavey chain (igh) gene. resection specimens were evaluated using he-stained sections, immunohistochemistry, in situ hybridization and pcr. histopathologic examination, immunohistochemistry and molecular studies showed the intermediate-sized lymphoma cells expressing cd2, cd3ε, granzyme b, tia-1, cd20 and epstein-barr virus-encoded rna, with g ... | 2017 | 29063643 |
| ebv-encoded ebna1 regulates cell viability by modulating mir34a-nox2-ros signaling in gastric cancer cells. | epstein-barr virus (ebv) nuclear antigen 1 (ebna1) is a viral protein expressed in all ebv-infected cells that induces malignant transformation. ebna1 is reported to contribute to tumor progression through an increase in reactive oxygen species via nicotinamide adenine dinucleotide phosphate oxidase. however, the underlying molecular mechanism of ebna1-induced ros accumulation in gastric cancer is poorly understood. here, we demonstrated that mir34a regulation by ebna1 determined cell fate in eb ... | 2017 | 29061308 |
| analysis of immunogenicity of intracellular ctar fragments of epstein-barr virus latent phase protein lmp1. | intracellular fragments of latent phase protein lmp1 of epstein-barr virus, denoted as ctar1/2/3, can trigger a variety of cell cascades and contribute to the transforming potential of the virus. generation of recombinant proteins ctar1/2/3 is expected to yield more ample data on functional and immunogenic characteristics of lmp1. we created genetic constructs for prokaryotic expression of lmp1 ctar fragments and selected optimal conditions for their production and purification. using a new libr ... | 2017 | 29063322 |
| clinical outcomes of residual or recurrent nasopharyngeal carcinoma treated with endoscopic nasopharyngectomy plus chemoradiotherapy or with chemoradiotherapy alone: a retrospective study. | local residual and recurrent nasopharyngeal carcinoma (npc) generally shows treatment failure after standard radiotherapy with or without concurrent chemotherapy. whether endoscopic nasopharyngectomy might provide an additional therapeutic advantage remains controversial. therefore, we retrospectively compared the clinical prognoses of patients with residual or recurrent npc treated with endoscopic nasopharyngectomy combined with chemoradiotherapy (crt) with those of patients treated with crt al ... | 2017 | 29038762 |
| latent hiv-1 tar regulates 7sk-responsive p-tefb target genes and targets cellular immune responses in the absence of tat. | the transactivating response element (tar) structure of the nascent hiv-1 transcript is critically involved in the recruitment of inactive positive transcription elongation factor b (p-tefb) to the promoter proximal paused rna polymerase ii. the viral transactivator tat is responsible for subsequent p-tefb activation in order to start efficient viral transcription elongation. in the absence of the viral transactivator of transcription (tat), e.g., during latency or in early stages of hiv transcr ... | 2017 | 29037489 |
| oncogenic epstein-barr virus recruits nm23-h1 to regulate chromatin modifiers. | in cancer progression, metastasis is a major cause of poor survival of patients and can be targeted for therapeutic interventions. the first discovered metastatic-suppressor nm23-h1 possesses nucleoside diphosphate kinase, histidine kinase, and dnase activity as a broad-spectrum enzyme. recent advances in cancer metastasis have opened new ways for the development of therapeutic molecular approaches. in this review, we provide a summary of the current understanding of nm23/ndpks in the context of ... | 2017 | 29035376 |
| the battle of rna synthesis: virus versus host. | transcription control is the foundation of gene regulation. whereas a cell is fully equipped for this task, viruses often depend on the host to supply tools for their transcription program. over the course of evolution and adaptation, viruses have found diverse ways to optimally exploit cellular host processes such as transcription to their own benefit. just as cells are increasingly understood to employ nascent rnas in transcription regulation, recent discoveries are revealing how viruses use n ... | 2017 | 29065472 |
| gammaherpesviral tegument proteins, pml-nuclear bodies and the ubiquitin-proteasome system. | gammaherpesviruses like epstein-barr virus (ebv) and kaposi's sarcoma-associated herpesvirus (kshv) subvert the ubiquitin proteasome system for their own benefit in order to facilitate viral gene expression and replication. in particular, viral tegument proteins that share sequence homology to the formylglycineamide ribonucleotide amidotransferase (fgarat, or pfas), an enzyme in the cellular purine biosynthesis, are important for disrupting the intrinsic antiviral response associated with promye ... | 2017 | 29065450 |
| epstein-barr virus infection and oral squamous cell carcinoma risk: a meta-analysis. | the evidence for association between epstein-barr virus (ebv) infection and risk of oral squamous cell carcinoma (oscc) is inconsistent in the literature. therefore, this meta-analysis was conducted to clarify this association. | 2017 | 29065191 |
| the potential of currently unavailable herpes virus vaccines. | despite overwhelming experimental work, there are no licensed vaccines against the most frequent alphaherpesviruses, namely herpes simplex virus 1 and 2 (hsv1 and 2) nor against the epstein-barr virus (ebv), a member of the subfamily gammaherpesvirus. areas covered: since the dnas of both hsvs reside in the regional sensory ganglia in a latent state (i.e. as circularized episomal molecules), a corresponding vaccine might be useful for immunotherapy rather than prevention of primary infection. he ... | 2018 | 29313728 |
| an anergic immune signature in the tumor microenvironment of classical hodgkin lymphoma is associated with inferior outcome. | the classical hodgkin lymphoma (chl) tumor microenvironment shows an ongoing inflammatory response consisting of varying degrees of infiltrating eosinophils, mast cells, macrophages, regulatory t lymphocytes (tregs), and activated lymphocytes surrounding the malignant cells. herein, different immune signatures are characterized and correlated with treatment outcome. | 2018 | 29064587 |
| complete response of age-related epstein-barr virus-associated polymorphic nodal lymphoproliferative disease of plasmacytic type to low-dose lenalidomide. | 2018 | 29063179 | |
| malaria, epstein-barr virus, vitamin a and burkitt's lymphoma: response to joob and wiwanitkit. | 2018 | 29055028 | |
| malaria, epstein-barr virus, vitamin a and burkitt's lymphoma. | 2018 | 29055026 | |
| epstein-barr virus positive diffuse large b cell lymphoma with g17v rhoa mutation arising from peripheral t cell lymphoma, not otherwise specified. | 2018 | 29063178 | |
| human papillomavirus and world health organization type iii nasopharyngeal carcinoma: multicenter study from an endemic area in southern china. | the current study was conducted to study the incidence of human papillomavirus (hpv)-associated nasopharyngeal carcinoma (npc) in southern china and the corresponding treatment outcome. | 2018 | 29072774 |
| epstein-barr virus positive diffuse large b-cell lymphoma presenting with vaginal sloughing and ulcerated skin nodule. | malignant lymphomas presenting in the female genital tract are extremely rare. we report a case of epstein-barr virus associated diffuse large b-cell lymphoma of the genital tract and skin in a 60-year-old woman on long-term azathioprine. | 2018 | 29086996 |
| epstein-barr virus protein eb2 stimulates translation initiation of mrnas through direct interactions with both poly(a)-binding protein and eukaryotic initiation factor 4g. | epstein-barr virus (ebv) expresses several mrnas produced from intronless genes that could potentially be unfavorably translated compared to cellular spliced mrnas. to overcome this situation, the virus encodes an rna-binding protein (rbp) called eb2, which was previously found to both facilitate the export of nuclear mrnas and increase their translational yield. here, we show that eb2 binds both nuclear and cytoplasmic cap-binding complexes (cbc and eukaryotic initiation factor 4f [eif4f], resp ... | 2018 | 29142127 |
| analysis of epstein-barr virus genomes and expression profiles in gastric adenocarcinoma. | epstein-barr virus (ebv) is a causative agent of a variety of lymphomas, nasopharyngeal carcinoma (npc), and ∼9% of gastric carcinomas (gcs). an important question is whether particular ebv variants are more oncogenic than others, but conclusions are currently hampered by the lack of sequenced ebv genomes. here, we contribute to this question by mining whole-genome sequences of 201 gcs to identify 13 ebv-positive gcs and by assembling 13 new ebv genome sequences, almost doubling the number of av ... | 2018 | 29093097 |
| early epstein-barr virus genomic diversity and convergence toward the b95.8 genome in primary infection. | over 90% of the world's population is persistently infected with epstein-barr virus. while ebv does not cause disease in most individuals, it is the common cause of acute infectious mononucleosis (aim) and has been associated with several cancers and autoimmune diseases, highlighting a need for a preventive vaccine. at present, very few primary, circulating ebv genomes have been sequenced directly from infected individuals. while low levels of diversity and low viral evolution rates have been pr ... | 2018 | 29093087 |
| b lymphoblastic leukemia/lymphoma with burkitt-like morphology and igh/myc rearrangement: report of 3 cases in adult patients. | isolated myc rearrangement without other recurrent genetic abnormalities is rare in b lymphoblastic leukemia/lymphoma (b-all/lbl), with most cases reported in pediatric patients. we report 3 adult cases with lymphoblasts showing a precursor b cell immunophenotype, and isolated myc/igh translocation. all 3 cases occurred in male patients with initial presentation of diffuse lymphadenopathy. cases 1 and 2 had b-all with significantly increased lymphoblasts in peripheral blood and bone marrow. case ... | 2018 | 29112016 |
| cancer therapy-associated lymphoproliferative disorders: an under-recognized type of immunodeficiency-associated lymphoproliferative disorder. | we describe the clinicopathologic features of 17 patients who had a hematologic malignancy of various types, were treated, and subsequently developed a lymphoproliferative disorder (lpd). there were 10 men and 7 women with a median age of 59 years (range, 36 to 83 y). the primary hematologic neoplasms included: 5 chronic lymphocytic leukemia/small lymphocytic lymphoma, 3 plasma cell myeloma, 2 acute monoblastic leukemia, and 1 case each of mixed-phenotype acute leukemia, chronic myeloid leukemia ... | 2018 | 29112013 |
| risk factors for post-transplant lymphoproliferative disorder after thymoglobulin-conditioned hematopoietic cell transplantation. | epstein-barr virus (ebv)-induced post-transplant lymphoproliferative disorder (ptld) occurs frequently when rabbit antithymocyte globulin (atg) is used in hematopoietic cell transplant (hct) conditioning. we retrospectively studied 554 patients undergoing atg-conditioned myeloablative hct. strategies used to minimize mortality due to ptld were either therapy of biopsy-diagnosed ptld in the absence of ebv dnaemia monitoring (n = 266) or prompt therapy of presumed ptld (based on clinical/radiologi ... | 2018 | 29114932 |
| conformational dynamics and free energy of bhrf1 binding to bim bh3. | the interaction between the bim bh3 peptide and the viral protein bhrf1 is pivotal to understanding the fundamental molecular details of the mechanism used by the epstein-barr virus to trick the mammalian immune system. here, we study the mechanism of binding/unbinding and compute the free energy for the association of the bim peptide to the bhrf1 protein. key elements of the binding mechanism are the conformational rearrangement together with a main free energy barrier of 11.5kcal/mol. the simu ... | 2018 | 29153883 |
| c-myc represses transcription of epstein-barr virus latent membrane protein 1 early after primary b cell infection. | recent evidence has shown that the epstein-barr virus (ebv) oncogene lmp1 is not expressed at high levels early after ebv infection of primary b cells, despite its being essential for the long-term outgrowth of immortalized lymphoblastoid cell lines (lcls). in this study, we found that expression of lmp1 increased 50-fold between 7 days postinfection and the lcl state. metabolic labeling of nascent transcribed mrna indicated that this was primarily a transcription-mediated event. ebna2, the key ... | 2018 | 29118124 |
| genomic profiles of nasopharyngeal carcinoma: the importance of histological subtyping and epstein-barr virus in situ assays. | 2018 | 29165785 | |
| oncogenic spiral by infectious pathogens: cooperation of multiple factors in cancer development. | chronic infection is one of the major causes of cancer, and there are several mechanisms for infection-mediated oncogenesis. some pathogens encode gene products that behave like oncogenic factors, hijacking cellular pathways to promote the survival and proliferation of infected cells in vivo. some of these viral oncoproteins trigger a cellular damage defense response leading to senescence; however, other viral factors hinder this suppressive effect, suggesting that cooperation of those viral fac ... | 2018 | 29143406 |
| metagenomic deep sequencing of aqueous fluid detects intraocular lymphomas. | currently, the detection of pathogens or mutations associated with intraocular lymphomas heavily relies on prespecified, directed pcrs. with metagenomic deep sequencing (mds), an unbiased high-throughput sequencing approach, all pathogens as well as all mutations present in the host's genome can be detected in the same small amount of ocular fluid. | 2018 | 29122821 |
| genetic predictors of response to systemic therapy in esophagogastric cancer. | the incidence of esophagogastric cancer is rapidly rising, but only a minority of patients derive durable benefit from current therapies. chemotherapy as well as anti-her2 and pd-1 antibodies are standard treatments. to identify predictive biomarkers of drug sensitivity and mechanisms of resistance, we implemented prospective tumor sequencing of patients with metastatic esophagogastric cancer. there was no association between homologous recombination deficiency defects and response to platinum-b ... | 2018 | 29122777 |
| programmed death-1 ligands pd-l1 and pd-l2 show distinctive and restricted patterns of expression in lymphoma subtypes. | the success of immunotherapy using immune checkpoint blockade in solid tumors and in relapsed/refractory classical hodgkin lymphoma and chronic lymphocytic leukemia holds promise for targeted therapy in hematologic malignancies. because efficacy of immunomodulatory therapy is correlated with numbers of cells that express programmed death (pd-1) ligands, we evaluated the expression of pd-l1 and pd-l2 proteins using immunohistochemistry in more than 702 diagnostic lymphoma biopsies. in classical h ... | 2018 | 29122656 |
| toll-like receptor 9 polymorphism is associated with increased epstein-barr virus and cytomegalovirus acquisition in hiv-exposed infants. | : polymorphisms in the toll-like receptor 9 1635 locus have been associated with hiv-1 acquisition and progression. cytomegalovirus (cmv) and epstein-barr virus (ebv) acquisition were compared between kenyan hiv-exposed infants by 1635 genotype. having one or more copies of the 1635a allele was associated with increased cmv acquisition in hiv-infected infants (42 vs. 11%, p = 0.03) and increased risk of ebv acquisition in hiv-exposed uninfected infants (hazard ratio = 4.2, p = 0.02) compared wit ... | 2018 | 29112074 |
| target-induced proximity ligation triggers recombinase polymerase amplification and transcription-mediated amplification to detect tumor-derived exosomes in nasopharyngeal carcinoma with high sensitivity. | tumor-derived exosomes (texs) are extracellular vesicles that are continuously released into the blood by tumor cells and carry specific surface markers of the original tumor cells. substantial evidence has implicated texs as attractive diagnostic markers for cancer. however, the detection of texs in blood at an early tumor stage is challenging due to their very low concentration. here, we established a method called pla-rpa-tma assay that allows texs to be detected with high sensitivity and spe ... | 2018 | 29145073 |
| reply to genomic profiles of nasopharyngeal carcinoma: the importance of histological subtyping and epstein-barr virus in situ assays. | 2018 | 29165787 | |
| an extremely rare case of epstein-barr virus-associated gastric carcinoma with differentiation to neuroendocrine carcinoma. | epstein-barr virus (ebv)-associated gastric carcinoma (ebvgc) is defined as a neoplasm comprising monoclonal proliferation of ebv-infected gastric epithelial cells. although the typical histology is gastric carcinoma with lymphoid stroma (gcls), the histologic features of the tumor vary. we report herein the case of a 78-year-old man with multiple simultaneous ebvgcs revealing different histopathologic morphologies; one was mixed adenoneuroendocrine carcinoma (manec), and the other was gcls. bot ... | 2018 | 29244230 |
| the alice-in-wonderland syndrome. | in 1955, english psychiatrist john todd defined the alice-in-wonderland syndrome (aiws) as self-experienced paroxysmal body-image illusions involving distortions of the size, mass, or shape of the patient's own body or its position in space, often accompanied by depersonalization and/or derealization. aiws had been described by american neurologist caro lippman in 1952, but todd's report was the most influential. todd named the syndrome for the perceptual disorder of altered body image experienc ... | 2018 | 29151098 |
| peroxiredoxin-2 and zinc-alpha-2-glycoprotein as potentially combined novel salivary biomarkers for early detection of oral squamous cell carcinoma using proteomic approaches. | no effective screening method is available for oral squamous cell carcinoma (oscc) that is recognized to influence by environmental factors as well as human papillomavirus (hpv) and epstein-barr virus (ebv). therefore, we sought to identify salivary biomarkers for screening of oscc with or without hpv and/or ebv infection. saliva, lesion and oral exfoliated cells were collected from oscc patients and cancer-free controls (cfcs) and grouped depending on their hpv- and ebv-infection status. saliva ... | 2018 | 29199150 |
| comparison of abbott architect®, siemens immulite®, and diasorin liaison® for determination of epstein-barr virus serological diagnosis. | this study compared the performance of 3 automated immunoassays, architect® (abbott), immulite® (siemens) and liaison® (diasorin), for epstein-barr virus (ebv) serology. ninety-one serum samples collected in amiens university hospital were analyzed for the presence of viral capsid antigen (vca) igg and igm and epstein-barr nuclear antigen (ebna) igg. the agreement between the 3 assays was calculated for each marker individually and for determination of the ebv profile, based on interpretation of ... | 2018 | 29198371 |
| epstein barr virus-associated smooth muscle tumour (ebv-smt) of the urinary bladder. | 2018 | 29226094 | |
| posttransplant lymphoproliferative disorders in epstein-barr virus donor positive/recipient negative lung transplant recipients. | epstein-barr virus (ebv) donor positive/recipient negative (d+/r-) status is a significant risk factor for posttransplant lymphoproliferative disorder (ptld) in lung transplant. there are, however, no studies that identify the risk factors for ptld in the ebv d+/r- lung transplant population to guide the decision to proceed with an ebv-positive donor. | 2018 | 29223419 |
| epstein-barr virus-associated hemophagocytic lymphohistiocytosis mimicking lymphoma on fdg pet/ct. | a 15-year-old boy with fever, pancytopenia, and hepatosplenomegaly was diagnosed as hemophagocytic lymphohistiocytosis (hlh). f-fdg pet/ct showed hypermetabolic foci in the liver, spleen, and bone marrow, as well as multiple fdg-avid lymph nodes, which were highly suggestive of lymphoma. specimens from splenectomy depicted a large number of macrophages/histiocytes with hemophagocytosis of erythrocytes, without evidence of malignancy. considering increased epstein-barr virus (ebv) dna in peripher ... | 2018 | 29215415 |
| potential cancer chemopreventive and anticancer constituents from the fruits of ficus hispida l.f. (moraceae). | ficus hispida l.f. (moraceae) has been used as alternative for traditional medicine in the treatment of various ailments including cancer-cure. the aim of this study was to evaluate the cancer chemopreventive and anticancer activities of crude extracts of f. hispida, with the objective to screen the inhibition of epstein-barr virus early antigen, and cytotoxic active components, and provide foundation for potential applications of this promising medical plant. | 2018 | 29197545 |
| viral dnaemia and immune suppression in pediatric sepsis. | demonstrate that dna viremia is common in pediatric sepsis and quantitate its associations with host immune function and secondary infection risk. | 2018 | 29189638 |
| visualizing single-cell secretion dynamics with single-protein sensitivity. | cellular secretion of proteins into the extracellular environment is an essential mediator of critical biological mechanisms, including cell-to-cell communication, immunological response, targeted delivery, and differentiation. here, we report a novel methodology that allows for the real-time detection and imaging of single unlabeled proteins that are secreted from individual living cells. this is accomplished via interferometric detection of scattered light (iscat) and is demonstrated with laz3 ... | 2018 | 29227108 |
| bone marrow involvement of epstein-barr virus-positive large b-cell lymphoma in a patient with angioimmunoblastic t-cell lymphoma. | 2018 | 29214764 | |
| direct substrate identification with an analog sensitive (as) viral cyclin-dependent kinase (v-cdk). | viral cyclin-dependent kinases (v-cdks) functionally emulate their cellular cdk counterparts. such viral mimicry is an established phenomenon that we extend here through chemical genetics. kinases contain gatekeeper residues that limit the size of molecules that can be accommodated within the enzyme active site. mutating gatekeeper residues to smaller amino acids allows larger molecules access to the active site. such mutants can utilize bio-orthoganol atps for phosphate transfer and are inhibit ... | 2018 | 29215867 |
| the impact of alternative donor types on viral infections in pediatric hematopoietic stem cell transplantation. | viral infections remain one of the most important complications following allogeneic hsct. few reports compare virus infection between different donor types in pediatric patients. we retrospectively analyzed viral infections and the outcome of one hundred and seventy-one pediatric patients (median 7.38 years) who underwent allogeneic hsct from matched related donor (mrd, n = 71), 10 of 10 hla allele-matched unrelated donors (mud1; n = 29), 9 of 10 hla allele-matched unrelated donors (mud2; n = 4 ... | 2018 | 29297965 |
| concurrent diffuse large b-cell lymphoma and epstein-barr virus-associated smooth muscle tumour in the small bowel of an hiv-positive adult-a case report and review of the literature. | 2018 | 29297137 | |
| viruses in chronic progressive neurologic disease. | viruses have long been implicated as triggers of disease onset and progression in multiple sclerosis (ms) and similar neuroinflammatory disorders. decades of epidemiological, molecular, and pathologic studies have most strongly linked the human herpesviruses epstein-barr virus (ebv) and human herpesvirus 6 (hhv-6) with ms. however, these viruses are ubiquitous in the general population and typically acquired decades before disease presentation, complicating the study of how they might contribute ... | 2018 | 29307291 |
| new interactors of the truncated ebna-lp protein identified by mass spectrometry in p3hr1 burkitt's lymphoma cells. | the epstein-barr virus nuclear antigen leader protein (ebna-lp) acts as a co-activator of ebna-2, a transcriptional activator essential for epstein-barr virus (ebv)-induced b-cell transformation. burkitt's lymphoma (bl) cells harboring a mutant ebv strain that lacks both the ebna-2 gene and 3' exons of ebna-lp express y1y2-truncated isoforms of ebna-lp (tebna-lp) and better resist apoptosis than if infected with the wild-type virus. in such bl cells, tebna-lp interacts with the protein phosphata ... | 2018 | 29303964 |
| epstein-barr virus-positive large cell neuroendocrine carcinoma of the nasopharynx: report of a case with complete clinical and radiological response after combined chemoradiotherapy. | neuroendocrine carcinomas of the head and neck are rare and are classified as well differentiated, moderately differentiated, and poorly differentiated carcinomas with the latter category being subdivided into small cell and large cell neuroendocrine carcinoma (lcnec). while most carcinomas in the nasopharynx are associated with epstein-barr virus (ebv), there has been only one previous report demonstrating a link between ebv and lcnec of the nasopharynx. in this report we describe a second case ... | 2018 | 29302900 |
| identification of a novel, ebv-based antibody risk stratification signature for early detection of nasopharyngeal carcinoma in taiwan. | epstein-barr virus (ebv) is necessary for the development of nasopharyngeal carcinoma (npc). by adulthood, ~90% of individuals test ebv-positive, but only a fraction develop cancer. factors that identify which individuals are most likely to develop disease, including differential antibody response to the virus, could facilitate detection at early stages when treatment is most effective. | 2018 | 29301829 |
| amegakaryocytic thrombocytopenia and subsequent aplastic anemia associated with apparent epstein-barr virus infection. | acquired amegakaryocytic thrombocytopenia (aat), a rare entity characterized by severe thrombocytopenia and the absence of megakaryocytes in the bone marrow, may mimic or precede the diagnosis of aplastic anemia (aa). here, we describe a patient who presented with apparent epstein-barr virus (ebv)-associated immune thrombocytopenia resistant to several lines of therapies, which was in fact a form of aat with some features of aa. he eventually responded to therapy with eltrombopag, cyclosporine a ... | 2018 | 29301129 |
| childhood nasopharyngeal carcinoma: state-of-the-art, and questions for the future. | in children, nasopharyngeal carcinoma (npc) is a very rare tumor, mostly epstein-barr virus related and quite always diagnosed at a locally advanced stage. with current protocols associating induction cisplatin-based chemotherapy and concomitant chemoradiotherapy, prognosis is excellent with overall survival higher than 85%. however, long-term toxicities are frequent. improvement in radiation therapy modalities like intensity-modulated radiation therapy and new strategies with radiation dose ada ... | 2018 | 29300240 |
| inverse correlation of vδ2+ t-cell recovery with ebv reactivation after haematopoietic stem cell transplantation. | epstein-barr virus (ebv) reactivation remains a life-threatening complication in recipients of a haploidentical haematopoietic stem cell transplantation (haplohsct). reconstitution of adaptive t lymphocytes is generally compromised at the early stages following transplant, suggesting an important role of other effector cells in preventing ebv infection. our previous studies demonstrated that recovery of cd4- cd8- t cells negatively correlated with ebv reactivation after haplohsct. in this prospe ... | 2018 | 29270985 |
| chemokine ccl27 is a novel plasma biomarker for identification the nasopharyngeal carcinoma patients from the epstein-barr virus capsid antigen-specific iga seropositive population. | to investigate the predictive value of chemokine ccl27 for identifying early stage nasopharyngeal carcinoma (npc) patients within a population seropositive for epstein-barr virus (ebv) capsid antigen-specific iga (vca-iga). | 2018 | 29295705 |