| infections and other maternal factors as risk indicators for congenital malformations: a case-control study with paired serum samples. | an obstetric population of 48,000 individuals was prospectively followed up for evidence of possible teratogenic factors that might be associated with congenital malformations. serum samples from 274 mothers of defective children and from paired controls were collected during early pregnancy and approximately one month after delivery and tested for antibodies against ten different viruses, mycoplasma pneumoniae, and toxoplasma. these data were supplemented with clinical information on infections ... | 1978 | 209394 |
| use of live varicella vaccine in children with acute leukemia. | seven children with acute leukemia were given a live attenuated varicella vaccine and successfully seroconverted with minimal clinical reactions. one of them was vaccinated immediately after the contact with natural varicella and successfully prevented from natural infection. | 1978 | 213857 |
| characterization of human varicella-zoster virus dna. | the dna of varicella-zoster virus (vzv) has been characterized by sucrose gradient sedimentation, restriction enzyme cleavage with either ecori or hindiii site-specific endonucleases, and by isopycnic banding in caesium chloride. comparisons of the dnas from different clinical isolates have been made. dnas from vzvs isolated from either varicella or herpes zoster are indistinguishable on the basis of size and restriction enzyme cleavage pattern. the buoyant density in caesium chloride of the dna ... | 1978 | 221365 |
| overview and horizons in prevention of some human infectious diseases by vaccination. | the present measles problem in the united states, an estimated 918,500 cases in 1977, is attributed to the failure of the 14-year vaccination program to immunize enough children to prevent continued circulation of the virus and recurrent outbreaks. a new strategy for rapidly overcoming this problem is recommended. there appears to be no current congenital rubella syndrome problem against which the rubella vaccination program in the united states is directed. however, the continued annual infecti ... | 1978 | 210652 |
| lymphocyte transformation and interferon production as measures of cellular immunity in lymphoma patients. | our studies of in vitro cellular immune responses to herpesviruses have shown that, before treatment, lymphoma patients have decreased transformation to varicella-zoster virus antigen compared to herpes simplex virus and cytomegalovirus antigens. interferon production to varicella-zoster virus and cytomegalovirus antigens is also decreased. during the first six months of treatment, decreased lymphocyte transformation and interferon production to all herpesviral antigens was observed. among patie ... | 1978 | 221398 |
| effect of ara-t on the replication of herpes simplex virus, varicella-zoster virus and cytomegalovirus. | the thymidine analogue, 1-beta-arabinofuranosylthymine (ara-t), has previously been found to selectively inhibit herpes simplex virus (hsv) replication. at a relatively non-toxic concentration (50 microgram/ml), ara-t reduced hsv yields by a factor of 10,000-100,000. ara-t was also effective in inhibiting the replication of variecella-zoster virus (vzv) in vitro in human embryo fibroblasts, completely preventing vzv-specific cytopathic effects (cpe). ara-t reduced the cell-free virus and plaque- ... | 1978 | 221418 |
| varicella-zoster virus. prospects for active immunization. | a live attenuated varicella-zoster (v-z) virus vaccine has been developed and tested by dr. m. takahashi and his colleagues in japan. this vaccine appears to prevent varicella and is associated with minimal side effects even in patients at high risk to develop severe varicella. antibody to v-z virus appears after v-z vaccination. this antibody has been detected by a variety of serologic technics, and it has been demonstrated to persist for as long as two years after vaccination. thus far, v-z va ... | 1978 | 210654 |
| [varicella vaccine]. | | 1978 | 211282 |
| neutralization test for varicella virus on vero cell monolayer. | | 1977 | 211308 |
| summary of a workshop on new and useful methods in viral diagnosis. | | 1978 | 212491 |
| bell's palsy and herpes simplex. | | 1978 | 213158 |
| persistence, reactivation, and cell transformation by human herpeviruses: herpes simplex 1, 2 (hsv-1, hsv-2), cytomegalovirus (cmv), varicella-zoster (vzv), epstein-barr virus (ebv). | | 1979 | 222414 |
| complement-enhanced neutralizing antibody response to varicella-zoster virus. | humoral immunity following infection with varicella-zoster virus (vzv) was evaluated by a complement-enhanced neutralization test. the specificity of the test was examined and its sensitivity compared with that of the assay which measures antibody to vzv-induced membrane antigen (fama). generally, the titer of neurtalizing antibody was two- to fourfold higher than the fama titer. the absence of neutralizing activity at a serum dilution of 1:4 indicated susceptibility of the donor to vzv infectio ... | 1979 | 220336 |
| a case of varicella pneumonia treated with transfer factor. | | 1979 | 220435 |
| simultaneous radioimmunoassay for specific antibodies to members of the human herpesvirus group. | a method of described for the simultaneous radioimmunoassay (ria) for antibody to members of the human herpesvirus group. the ria is compared with some of the conventional serologic techniques used to quantitate antibody to these viruses (epstein-barr virus, cytomegalovirus, herpesvirus type 1 and varicella-zoster virus). color-coded beads, each coated with the antigens of a different herpesvirus, were similtaneously placed in a well which contained a human serum to be assayed for antibody to ea ... | 1979 | 222846 |
| [virus secretion in varicella]. | | 1979 | 220476 |
| [incidence and prevalence of antibodies to measles, herpesvirus infections, mumps and rubella in the cerebrospinal fluid and serum of subjects with abiotrophic-degenerative type diseases of the central nervous system]. | | 1978 | 216379 |
| viral antibodies in serum and csf of parkinsonian patients and controls. | | 1979 | 224845 |
| antibody assays for varicella-zoster virus: comparison of enzyme immunoassay with neutralization, immune adherence hemagglutination, and complement fixation. | an enzyme immunossay (eia) was adapted for detection of antibody to varicella-zoster virus, and its sensitivity and specificity were compared with those of neutralization, immune adherence hemagglutination (iaha), and complement fixation tests. test sera showed little nonspecific reactivity in the eia system, and valid results could usually be obtained at serum dilutions as low as 1:8. demonstration of the presence or absence of varicella-zoster viral antibody by eia showed 94% correlation with ... | 1978 | 215602 |
| cell-mediated immunity to varicella-zoster virus measured by virus inactivation: mechanism and blocking of the reaction by specific antibody. | the process whereby varicella-zoster (v-z) virus is inactivated in vitro by immune human peripheral blood leukocytes stimulated with v-z antigen was examined. it was found that stimulation of leukocytes by v-z antigen, but not by other viral antigens, was required for inactivation of v-z virus to occur. viral inactivation could be blocked by addition of v-z antiserum to either the stimulation phase of the reaction or the inactivation phase, further demonstrating the specificity of the reaction. ... | 1979 | 225269 |
| cellular and humoral immune responses to varicella-zoster virus in immunocompromised patients during and after varicella-zoster infections. | humoral and cell-mediated immune responses to varicella-zoster (v-z) virus were assessed in patients during and after v-z infections. ongoing v-z infections was associated with minimal cellular immunity but not necessarily with poor humoral immunity. recovery from v-z infection was associated with a vigorous cellular immune response. cell-mediated immunity to v-z virus was demonstrable for years after varicella, but responses were lower in immunocompromised patients than in normal individuals. | 1979 | 225270 |
| viremia caused by varicella-zoster virus: association with malignant progressive varicella. | | 1979 | 225391 |
| [characteristics of the complement-fixing antibody response for varicella-zoster virus in patients with herpes zoster]. | | 1977 | 218503 |
| [new viral vaccines, with special reference to chickenpox vaccine]. | | 1978 | 215679 |
| varicella-zoster virus immunizes patas monkeys against simian varicella-like disease. | to define further the antigenic relationship between human varicella-zoster virus and herpesviruses which produce varicella-like disease in certain simian species, patas monkeys were inoculated with varicella-zoster virus and then challenged with delta herpesvirus, which uniformly produces severe, clinically apparent disease in susceptible animals. protection against delta herpesvirus was conferred both by hyperimmunization with varicella-zoster virus and by a single immunization with a cell-fre ... | 1979 | 215708 |
| [incidence and prevalence of antibodies to measles, herpesvirus infections, mumps and rubella in the cerebrospinal fluid and serum of subjects with demyelinating diseases of the central nervous system]. | | 1978 | 216380 |
| shingles: a belt of roses from hell. | | 1979 | 216456 |
| immunization: varicella-zoster vaccine. | | 1979 | 217569 |
| sensitive solid-phase radioimmunoassay for detection of human immunoglobulin g antibodies to varicella-zoster virus. | a sensitive solid-phase radioimmunoassay for detection of antibodies to varicella-zoster virus (vzv) is described. the antigen consisted of a sonically disrupted extract of vzv-infected human embryo cells. 125i-labeled rabbit anti-human immunoglobulin g (igg) specific for the fc portion of human igg was used to detect human igg bound to viral antigen. with this technique, 193 human sera were evaluated for their igg antibody titer against zvz. subjects included 62 healthy adults, 33 young childre ... | 1979 | 219015 |
| csf viral antibodies. evaluation in amyotrophic lateral sclerosis and late-onset postpoliomyelitis progressive muscular atrophy. | serum and csf from 48 patients with amyotrophic lateral sclerosis and six patients with late-onset postpoliomyelitis progressive muscular atrophy were investigated for the presence of antibody to poliovirus types 1, 2, and 3, coxsackie viruses b3 and b4, influenza a, measles, rubella, mumps, herpes simplex types 1 and 2, cytomegalovirus, varicella-zoster, and toxoplasma gondii. these results were compared with those from 53 control patients with neuromuscular disease matched for age, sex, race, ... | 1979 | 220938 |
| antibody to varicella-zoster virus after passive immunization against chickenpox. | antibody titers to varicella-zoster virus were measured in varicella-susceptible immunocompromised children 48 h after they received either one of two lots of zoster immune globulin (zig) or a selected lot of immune serum globulin (isg). globulin was given to modify varicella in these children after exposure to varicella or zoster. indirect immunofluorescence antibody titers (fama) of children after receipt of globulin ranged from less than 1:2 to 1:32. geometric mean fama titers were highest af ... | 1978 | 217893 |
| a live varicella vaccine used for children in hospitals. | a live varicella vaccine was developed and the following results obtained: 1. the vaccine was safely and effectively used for children in hospital with various underlying diseases; some of the children had been receiving immunosuppressive therapy. 2. spread of varicella could be prevented by immediate inoculation of the vaccine in hospital or at home when vaccine was given to susceptible children within 72 hours after exposure. 3. persistence of neutralizing antibody and prevention of natural va ... | 1978 | 221371 |
| nervous system complications of herpes zoster: immunofluorescent demonstration of varicella-zoster antigen in csf cells. | | 1979 | 221620 |
| antiherpesvirus activity in human sera and urines after administration of adenine arabinoside: in vitro and in vivo synergy of adenine arabinoside and arabinosylhypoxanthine in combination. | the minimum inhibitory concentration (mic) of adenine arabinoside (ara-a) in rabbit kidney microtiter tissue cultures (rk-13) to a prototype strain of herpes simplex virus, type 1 (e115) based upon inhibition of cytopathic effects is 1.5 mug/ml. in this system, the mic of arabinosylhypoxanthine (ara-hx), the major in vivo metabolic derivative of ara-a, is 75 mug/ml. inhibition of cytopathic effects of herpes simplex virus, type 1 (hsv-1) in microtiter wells of rk-13 cells varies directly with th ... | 1978 | 219024 |
| growth inhibition by acycloguanosine of herpesviruses isolated from human infections. | inhibition by acycloguanosine (acg) of plaque formation by harpes simplex virus types 1 and 2 (hsv-1 and hsv-2), varicella-zoster virus, and cytomegalovirus was studied. seventeen clinical isolates of hsv-1 were inhibited by acg at a mean 50% inhibitory dose (id(50)) of 0.15 +/- 0.09 mum. the mean id(50) for 10 isolates of hsv-2 was 1.62 +/- 0.76 mum, and for four isolates of varicella-zoster virus it was 3.75 +/- 1.30 mum. the id(50)'s for two cytomegalovirus isolates were 100 and 160 mum, and ... | 1979 | 230783 |
| [comparative study of anti ebv antibodies in non-hodgkin's lymphomams and angio-immunoblastic lymphadenopathies (author's transl)]. | antibody titers to epstein-barr virus (ebv)--related antigens (viral capsid antigen : vca; early antigen : ea; and ebv associated nuclear antigen : ebna) were determined in the sera of 86 patients and 150 matched control subjects. the patients belonged to four histological groups : diffuse and nodular non-hodgkin's lymphomas angio-immunoblastic lymphadenopathies and apparented syndroms. the incidence of antibodies to other herpes-viruses (cytomégalovirus, herpes simplex virus, and varicella zost ... | 1979 | 230873 |
| use of a live varicella vaccine for acute leukemic children shortly after exposure in a children's ward. | | 1978 | 219841 |
| specific immunoglobulin responses after varicella and herpes zoster. | the indirect immunofluorescence technique has been used to titrate the specific immunoglobulins in 200 sera from 64 patients with varicella, and 195 sera from 67 patients with herpes zoster. igg and igm antibodies were detected in all patients with varicella, and iga in 59 (92%). all three classes of antibody appeared 2--5 days after the onset of the rash, increased virtually simultaneously and reached maximum titres during the second and third weeks. igg then declined slowly, but never became u ... | 1979 | 219110 |
| [clinical immunological characteristics of herpes zoster]. | changes of antibody formation of 96 patients with various clinical forms of herpes zoster were traced by indirect hemagglutination inhibition test. four variants of the immunological response were distinguished; clinical characteristics of each of these groups is presented. the initial antibody level failed to determine the severity of the course of the disease in herpes zoster. | 1978 | 218405 |
| [herpesviruses in man]. | the importance and the extent of the inter-actions between herpes viruses and man is beginning to be understood. as more is learned about the natural histories of these viruses, it is becoming apparent that they have in common: horizontal spread during childhood, often with subclinical infection. latency in the host for many years, probably for life. potential for reactivation at a later time. host immune response maintained for life. potential for oncogeneiss. a more thorough knowledge of the b ... | 1979 | 222711 |
| recent developments in immunization. | | 1979 | 223185 |
| effect of 5-iodo-5'-amino-2',5'-dideoxyuridine on varicella-zoster virus in vitro. | the antiviral effect of the nucleoside analog 5-iodo-5'-amino-2',5'-dideoxyuridine (aiu) was tested with three isolates of varicella-zoster virus (vzv). aiu concentrations of 10 to 800 mum (3.5 to 288 mug/ml) reduced the number of plaques produced by vzv-infected cells and cell-free vzv from approximately 30 to 95%. smaller plaque size was also observed in the presence of aiu. aiu was less effective than arabinofuranosylthymine in reducing vzv-induced plaques since as little as 5 mug of arabinof ... | 1979 | 224809 |
| studies on the polypeptides of varicella-zoster (v-z) virus. 1. detection of varicella-zoster virus polypeptides in infected cells. | virus-induced polypeptides in cells infected with varicella-zoster virus (vzv) were analyzed by sds-polyacrylamide gel electrophoresis (sds-page) and autoradiography. when human embryonic lung (hel) cells infected with the oka strain of vzv were labelled with 35s-methionine or 14c-glucosamine from 40 hr to 46 hr after infection, at least 18 vzv-induced polypeptides and 10 glycoproteins could be identified in the infected cells. the molecular weights of the polypeptides and glycoproteins ranged ... | 1979 | 231438 |
| comparative study of herpes group virus-induced dna polymerases. | a comparative biochemical study of virus-induced dna polymerases was made among the herpes group viruses: namely, herpes simplex virus (hsv) type 1 and type 2, human cytomegalovirus (hcmv) and varicella-zoster virus (vzv). although these virus-induced enzymes shared some biochemical properties, they differed in several important aspects. all these virus-induced dna polymerases could efficiently use poly(dc) . oligo(dg)12--18 and poly(da) . oligo(dt)12--18 as template-primers. however, in phospho ... | 1979 | 231586 |
| serological studies on the antigenic relationship between herpes simplex virus and varicella-zoster virus. | if crossreacting antibodies between varicella-zoster virus (vzv) and herpes simplex virus (hsv) exist, one would expect more positive reactions with vzv in a group of hsv positive patients than in a group of hsv negative patients. this statement can only apply to a group of individuals where positive and negative reactions with respect to hsv and vzv are evenly distributed. such a distribution can only be found among children. therefore, the relationship between hsv-1 and vzv was the only one wh ... | 1979 | 232073 |
| [immunological study of 7 cases with ramsay hunt's syndrome (author's transl)]. | | 1979 | 225075 |
| the serological relationship of varicella-zoster virus to other primate herpesviruses. | the serological relationship between viruses producing varicella-like exanthems in several subhuman primates, varicella-zoster virus (vzv) and herpes simplex viruses (hsv) types 1 and 2, was investigated. all the primate viruses were related to vzv and some to hsv also. these results show that there is a group of varicella viruses, comprising four distinct entities, some of which may be useful for the establishment of an animal model for varicella. | 1979 | 232132 |
| infection and persistence of varicella-zoster virus in lymphoblastoid raji cell line. | infection of raji cells by varicella-zoster virus (vzv) resulted in permissive infection with establishment of a persistently infected lymphoblastoid cell line. vzv antigens of the membrane and nuclear type, as detected by the indirect immunofluorescence membrane antigen (ifama) and anticomplement immunofluorescence (acif) tests, were observed. minute amounts of infectious virus were detected by co-cultivation of vzv-infected raji cells (raji-vzv), with permissive human embryo fibroblasts (hef). ... | 1979 | 232537 |
| cell-free varicella-zoster virus in cultured human melanoma cells. | varicella-zoster virus (vzv) has been isolated and serially propagated in a continuous cell line derived from a human malignant melanoma tumour. human melanoma cells (hmc) have been further evaluated as a substrate for the production of cell-free virus and compare favourably with human embryo cells. within 60 h after inoculation with vzv-infected cells, hmc monolayers incubated at 32 degrees c exhibited advanced syncytial cytopathic effect, and the overlying culture medium contained greater than ... | 1979 | 225414 |
| [fatal varicella pneumonia in adults. report of two cases and review of literature (author's transl)]. | two mortal cases of varicella pneumonitis are described. the patients were respectively 41 and 34 years-old men of good health. they caught the disease from their children. the disease lasted one week, and death was due in both cases to respiratory failure. the autopsy confirmed massive lung involvement with varicella pneumonia, and also showed other organs involvement (liver, spleen, pancreas, lymph nodes, oesophagus). in both cases, human fibroblast cultures infected by material obtained from ... | 1979 | 227015 |
| viral vaccines under development: a third generation. | in summary then, my purpose has been two-fold: on the one hand, i have tried to highlight the kinds of basic science advances in both cellular and virologic research that can (and should) be focussed both on vaccines under development and, retrospectively, on those whose origins were strictly empiric. on the other hand, i have attempted a partial survey of some of the prominent members of a potential new generation of vaccines to point out areas where these advances can and should contribute eit ... | 1979 | 227237 |
| [life-threatening generalized varioloid zoster with zoster pneumonia due to combined immunologic deficiency. increased contagiousness of this disease]. | there is a clear-cut correlation between the clinical course of an herpes zoster and the quality of immune response. a varioloid generalized herpes zoster accompanied by zoster-pneumonia developed in a forty years old female patient with metastasizing breast cancer treated with x-ray and cytostatic drugs. the particularly serious course of this herpes zoster was brought about by combined immune deficiency, consisting of low level of circulating t-lymphocytes (5/mm3) and for a long time lacking r ... | 1977 | 300529 |
| induction of thymidine kinase and dnase in varicella-zoster virus-infected cells and kinetic properties of the virus-induced thymidine kinase. | thymidine kinase (tk), dna polymerase, and dnase activities were induced in human foreskin fibroblasts after varicella-zoster virus infection. the induced tk and dnase activities have electrophoretic mobilities different from the corresponding host enzymes. varicella-zoster virus-induced tk was purified and separated from the host enzyme by affinity column chromatography. this enzyme has been shown to have a broader substrate specificity with respect to either the phosphate donor or acceptor as ... | 1979 | 228052 |
| cytological diagnosis of virus-infected cells in papanicolaou smears and its application in clinical practice. | the cytopathic changes of herpes simplex virus, varicella-zoster virus, the human polyomaviruses, and the trachoma agent can be recognised in smears prepared from a wide variety of specimens. the morphology of virus-infected cells is described, and the clinical value of these observations is discussed. cytological diagnosis offers a rapid and convenient method of detecting infection with these viruses which can be confirmed by conventional virological method while the patient is still in the acu ... | 1979 | 229124 |
| [infection by varicella-zoster virus in patients with renal allotransplants]. | | 1979 | 388592 |
| prolonged herpes-zoster infection associated with immunosuppressive therapy. | unusually prolonged zoster was observed in four patients, two with cardiac transplants, one with acute lymphocytic leukemia, and one with diffuse histiocytic lymphoma. lesions increased in number and persisted for 5 to 24 weeks before beginning to resolve. specific cellular-immune responsiveness to varicella-zoster virus was markedly depressed during these infections. absolute numbers of t lymphocytes were also very low. reducing immunosuppressive therapy to increase immune responses appeared to ... | 1979 | 391116 |
| indirect immunofluorescence test for detection of igm antibodies to cytomegalovirus. | a technique for the detection of igm antibodies to cytomegalovirus (cmv) by immunofluorescence was developed. in order to prevent interference by rheumatoid factor in the sera, igg was removed by prior immunoabsorption with antiserum to gamma fc. sera from 63 patients with a rise in titer of antibody to cmv, indicated by complement fixation, were igm-positive, but yielded negative results on the paul-bunnell-davidsohn test for infectious mononucleosis. convalescent-phase serum samples from 20 pa ... | 1979 | 229176 |
| antibody to varicella-zoster virus-induced membrane antigen: immunoperoxidase assay with air-dried target cells. | a technique using indirect immunoperoxidase antibody to membrane antigen (ipama) was developed for detection of igg antibody to varicella-zoster virus (vzv). the ipama technique utilizes glass slides with air-dried vzv-infected cells, which can be stored at -70 c and used for several months without loss of sensitivity. antibody titers measured by the ipama technique were comparable to those measured by the technique using indirect fluorescent antibody to membrane antigen (ifama) for sera obtaine ... | 1979 | 229177 |
| analysis of the dnas from seven varicella-zoster virus isolates. | the 32p-labeled dnas from seven different clinical isolates of human varicella-zoster virus (vzv) were independently digested with five site-specific restriction endonucleases, ecori, hindiii, smai, bamhi, and avai. the digestion products were analyzed by electrophoresis on 0.5% agarose gels followed by autoradiography of the dried gels. evaluation of the restriction enzyme cleavage patterns revealed small variations among the vzv dnas. the vzv dnas were also compared based on their buoyant dens ... | 1979 | 229268 |
| [electron microscopy diagnosis of herpes zoster virus in cancer patients]. | | 1979 | 229536 |
| serum antibody levels as risk factors in the dissemination of herpes zoster. | serum antibody levels against varicella-zoster virus (vzv) were examined by immune adherence hemagglutination assay (iaha), indirect fluorescent antibody (ifa) assay, and complement fixation techniques in 67 immunocompromised patients with localized and disseminated herpes zoster. in the serum obtained initially, undetectable iaha titers were found in 56.5% of the patients with disseminated zoster compared with 18.2% of those with localized zoster. when serum obtained within the first seven days ... | 1979 | 229783 |
| first experiences with varicella-immunizations. | | 1979 | 230115 |
| antibodies to epstein-barr virus-determined antigens in normal subjects and in patients with seropositive rheumatoid arthritis. | prior studies have shown that patients with seropositive rheumatoid arthritis (ra) have an increased frequency of precipitating antibody against a nuclear antigen, the ra nuclear antigen, detected in human b lymphoblastoid cell lines infected by epstein-barr virus. the present investigations demonstrate that patients with seropositive ra also have specifically elevated titers of antibodies to another, better-characterized epstein-barr virus-associated b cell antigen, the epstein-barr nuclear ant ... | 1979 | 230491 |
| zoster immune plasma prophylaxis of varicella: a follow-up report. | | 1979 | 221631 |
| comparison of rates of virus isolation from leukocyte populations separated from blood by conventional and ficoll-paque/macrodex methods. | one hundred fifty-two blood specimens, largely from immunocompromised patients, were collected in heparinized vacutainer tubes and divided into paired aliquots of equal volume. buffy-coat preparations, containing mixed leukocyte and separate mononuclear and polymorphonuclear leukocyte populations were obtained by treatment of blood with conventional and ficoll-paque/macrodex (f-p/m) methods. the development of cytopathic effect in monolayers of wi-38 fibroblasts inoculated with cell suspensions ... | 1979 | 231049 |
| effects of adenine arabinoside on cellular immune mechanisms in humans. | in vitro lymphocyte blastogenic responses to the commonly employed mitogens, phytohemagglutinin, pokeweed, and concanavalin a, were evaluated when adenine arabinoside (ara-a) in a concentration of 3 mug/ml was added to the culture materials. similarly, blastogenic and cytotoxic responses to cell cultures persistently infected with herpes simplex virus 1, herpes simplex virus 2, and varicella-zoster virus were determined in the presence of ara-a. no depression of these cellular immune responses b ... | 1975 | 1137371 |
| detection of viremia during incubation of varicella. | | 1979 | 221632 |
| management of pregnant patient exposed to varicella. | | 1979 | 221641 |
| [the prevention of chickenpox in high risk children. comparison of the effectiveness of specific immunoglobulins and of defibrinated convalescent plasma. 414 cases (author's transl)]. | comparison between 157 children treated with defibrinated convalescent plasma and 257 children treated with specific immunoglobulins revealed the improved effectiveness of the latter treatment in the prevention of chickenpox. specific herpes zoster-chickenpox immunoglobulins are prepared by caprylic acid fractionation of convalescent plasma. the prevention obtained in more than 90% of cases would appear to be clinically and biologically total as shown by serological surveillance of certain child ... | 1979 | 221885 |
| detection of herpesvirus dna in the large intestine of patients with ulcerative colitis and crohn's disease using the nested polymerase chain reaction. | the prevalence of herpesvirus dna was examined in inflammatory bowel disease tissue. dna was extracted from resection and biopsy specimens of the large intestine from patients with ulcerative colitis (n = 21), patients with crohn's disease (n = 29), and patients with noninflammatory bowel disease (controls) (n = 21). the nested polymerase chain reaction was used to detect viral dna using primer pairs specific for either cytomegalovirus (cmv), herpes simplex virus 1 (hsv1), human herpesvirus 6 (h ... | 1992 | 1287131 |
| ocular surface manifestations of the major viruses. | the ocular surface is often the first site of involvement by viral infections. background information, clinical presentations, and current treatment of three major viruses--herpes simplex, varicella-zoster, and adenovirus, have been presented in detail in this chapter. the effects of adenoviruses are usually transient and may be regarded as a nuisance. infection with herpes simplex or varicella-zoster may lead to prolonged activity of the disease and life-long treatment with occasional loss of u ... | 1979 | 222704 |
| [the molecular biology of herpes viruses: (part ii) dna structure analysis and latent viral genomes of ebv, mdv, h. saimiri, cmv etc. (author's transl)]. | | 1979 | 231281 |
| comparison of 4 serological tests--complement fixation, neutralization, fluorescent antibody to membrane antigen and immune adherence hemagglutination--for assay of antibody to varicella-zoster (v-z) virus. | four tests for antibody to varicella-zoster (v-z) virus were compared; these were tests of complement fixation (cf), neutralization (nt), fluorescent antibody to membrane antigen (fama) and immune adherence hemagglutination (iaha). fifty-two sera from patients with varicella and zoster and from recipients of live varicella vaccine were examined by the 4 tests. the cf test was least sensitive, but the antibody titers by the nt, fama and iaha tests were roughly comparable. the iaha test was the si ... | 1979 | 231433 |
| a serological survey of st lucia. | a serological survey of a random sample of 541 of the population of st lucia was undertaken. the prevalence of antibodies to dengue, herpes virus, vz, rotavirus, rubella and syphilis is described and compared with other communities. | 1979 | 232090 |
| appearance of immunoglobulin g fc receptor in cultured human cells infected with varicella-zoster virus. | after infection with varicella-zoster virus, hela and human embryo lung cells developed a receptor for the fc portion of human and rabbit immunoglobulin g. the receptor was detected by both hemadsorption and immunofluorescence, using antibody-coated erythrocytes and heat-aggregated immunoglobulin g. however, sheep erythrocytes sensitized with f(ab')2 of anti-sheep erythrocyte antibody did not adsorb to the receptor. when cell-free varicella-zoster virus was inoculated into the hela cell monolaye ... | 1979 | 232695 |
| complement fixing antibody to varicella-zoster virus in cancerous patients. | the titer of complement fixing antibody to varicella-zoster virus was studied in sera from 161 cancerous patients and 161 healthy controls. sera with antibody titers greater than or equal to 1/4 were 74 (45.9%) among cancerous patients and 120 (74.5%) among healthy controls. the difference between these two groups is statistically significant. | 1979 | 233341 |
| [serological survey for virus and mycoplasma infections (author's transl)]. | the authors describe the two years follow up of complement fixing antibodies vs 4 viral antigens (herpes simplex, herpes zoster, cytomegalovirus, respiratory syncytial virus, mycoplasma pneumoniae). they evaluate the seasonal trend and the eventual clinical correlations on 3267 sera and 254 spinal fluids from hospitalized patients. | 1979 | 233415 |
| [severe generalized courses of zoster due to cellular immunologic defects. importance of an absolute or relative t-cell deficiency]. | four patients with chronic lymphatic leukaemia, m. hodgkin and metastatic breast carcinoma developed particularly severe generalised herpes zoster, with complications of herpes zoster pneumonia, signs of encephalitis and phrenic nerve paresis. virus specific complement-fixing antibodies increased regularly or delayed, without strict correlation to the clinical course. however, in all these cases there was a relative or absolute deficiency of t-lymphocytes in the peripheral blood, as a result of ... | 1978 | 305913 |
| pharmacologic effects of polyinosinic-polycytidylic acid in man. | twenty-four patients with cancer and concomitant infections with either herpes virus hominis or varicella zoster virus were treated with polyinosinic-polycytidylic acid (rin.rcn) to determine: 1) the reliability of rin.rcn to induce interferon production, and 2) the toxicity of the drug. seven additional patients with herpes zoster were observed as controls. two lots of rin.rcn were used; lot 1 was consistently effective in stimulating serum interferon at doses of 9 and 12 mg/kg, whereas lot 2 w ... | 1977 | 347034 |
| [laboratory diagnosis of varicella-zoster virus infections]. | | 1979 | 396181 |
| ocular pathology of the congenital varicella syndrome. | congenital anomalies are rare in infancy following maternal varicella during pregnancy. abnormalities do occur, however, and form a specific pattern including cicatrical skin lesions, atrophic limb, low birth weight, and chorioretinal scarring. we saw an infant who had immunologic evidence of varicella-zoster virus contact in utero, microphthalmos of one eye, and chorioretinal scarring of the fellow eye. ophthalmologists confronted with such ocular anomalies in children should inquire about the ... | 1977 | 411463 |
| demonstration of anti-rubella antibody-secreting cells in rheumatoid arthritis patients. | in the present study we describe a plaque-forming cell assay using erythrocytes coated with viral antigen, which detected anti-viral antibody-secreting cells against various viral antigens. these anti-viral antibody-secreting cell were studied in normal individuals with known viral infections and in rheumatoid arthritis patients. rubella anti-viral antibody-secreting cells were present after induction in the peripheral blood of eight out of ten patients. no plaques were seen before induction. sy ... | 1979 | 472665 |
| effects of interferon and adenine arabinoside treatment of hepatitis b virus infection on cellular immune responses. | fifteen patients with chronic hepatitis b were treated with adenine arabinoside (ara-a) or human leukocyte interferon (hli). cellular immune response to hepatitis b virus surface antigen and antigens prepared from herpes simplex virus, varicella zoster virus, and cytomegalovirus was measured by a lymphocyte blast transformation assay and an assay for interferon production. measurements were made before, during, and after antiviral treatment. unlike patients convalescing from acute hepatitis b, o ... | 1979 | 533259 |
| bell's palsy--varicella zoster and meningitis. | two cases with bell's palsy due to varicella zoster virus in children are reported. it is suggested that pyogenic meningitis resulting in lowered body resistance reactivated the latent v.z. virus. | 1977 | 604398 |
| cell-mediated immunity to varicella-zoster virus infection in subjects with lymphoma or leukemia. | normal subjects and patients with lymphoma or leukemia were tested for the levels of lymphocytes, e-rosette--forming t-cells, serum and vesicle fluid interferon, and specific in vitro proliferative response to varicella-zoster antigen after clinical varicella or herpes zoster illness. the effect of polyinosinic acid/polycytidilic acid on the immune response was also evaluated. the development of vz specific cell-mediated response in normal subjects was characterized by intense proliferative acti ... | 1979 | 762611 |
| [varicella-zoster virus infections. course, virologic findings and therapeutic trials in healthy and in immunologic disease children]. | | 1976 | 934134 |
| viral infection as a cause of acute peripheral facial palsy. | among 51 patients with acute peripheral facial palsy, varicella-zoster virus was isolated from the cerebrospinal fluid (csf) in one case, and herpesvirus hominis from the nasopharynx in two cases. in 12 other cases, complement-fixing antibody or hemagglutination inhibition tests indicated a recent viral infection (varicella-zoster, seven; herpes simplex, one; cytomegalovirus, one; influenza type b virus, two; and mumps virus, one). one additional patient had clinical signs of herpes zoster oticu ... | 1976 | 938319 |
| the role of viral infection in acute peripheral facial palsy. | thirty-three patients with acute non-traumatic peripheral facial palsy were studied. in one patient, varicella-zoster virus was isolated from csf. antibody against the same virus was present in csf, and rising titre was demonstrated in serum. in two cases, herpes virus hominis was isolated from the nasopharynx. cf-antibody tests indicated recent viral infection in 7 other cases. one additional patient had clinical signs of herpes zoster oticus. in most of these 11 patients, but also in the major ... | 1975 | 1136761 |
| human sera from varicella-zoster virus (vzv) infections cross-react with human t cell leukaemia virus type 1 (htlv-1): common epitopes in vzv gene 22 protein and htlv-1 p19 gag protein. | twenty-nine of 100 sera from patients recently infected with varicella-zoster virus (vzv) were found to cross-react with human t cell leukaemia virus type 1 (htlv-1) antigen in the particle agglutination (pa) assay using htlv-1 antigen-coated gelatin particles. anti-vzv igm antibodies were shown to be responsible for this cross-reactivity. western blot analysis revealed that pa-positive anti-vzv sera reacted with the htlv-1 gag p19 protein in htlv-1-infected cells and recombinant p19 protein pro ... | 1992 | 1279104 |
| complement fixing antibody to varicella-zoster virus in different age groups. | | 1979 | 231058 |
| radioimmunoassay for antibodies in varicella-zoster virus serology. | the method of ria for antibodies was employed with success in vz virus serology. the method is suitable for testing vz antibodies in the course of varicella or herpes zoster disease as well as for determining anamnestic titres. its advantages are stability of antigen, objective reading of results and applicability to testing large serum sets. | 1979 | 231068 |
| major histocompatibility complex (mhc) antigen expression in hiv encephalitis. | in order to study possible immunopathogenic mechanisms in human immunodeficiency virus (hiv) encephalitis, immunocytochemical localization of class i and class ii major histocompatibility complex (mhc) antigens was studied in formalin-fixed tissue sections from the brains of 10 individuals who had died with this disorder. using the avidin biotin peroxidase technique and monoclonal antibodies to these antigens, increased expression of class i antigens was found in five out of 10 and of class ii a ... | 1992 | 1280786 |
| zoster immunoglobulin (zig) | | 1979 | 231189 |
| acyclovir treatment of varicella in otherwise healthy adolescents. the collaborative acyclovir varicella study group. | to determine whether orally administered acyclovir is of therapeutic benefit for varicella in otherwise healthy adolescents, and to compare the severity of the disease in adolescents with that in younger children. | 1992 | 1313098 |
| the unique sequence of the herpes simplex virus 1 l component contains an additional translated open reading frame designated ul49.5. | we present evidence for the existence of an additional herpes simplex virus 1 gene designated ul49.5. the sequence, located between genes ul49 and ul50, predicts a hydrophobic protein with 91 amino acids. attempts to delete ul49.5 were not successful. to demonstrate that ul49.5 is expressed, we made two recombinant viruses. first, we inserted in frame an oligonucleotide encoding a 15-amino-acid epitope known to react with a monoclonal antibody. this gene, consisting of the authentic promoter and ... | 1992 | 1309263 |
| subclinical varicella-zoster virus viremia, herpes zoster, and t lymphocyte immunity to varicella-zoster viral antigens after bone marrow transplantation. | bone marrow transplant (bmt) recipients were evaluated for subclinical varicella-zoster virus (vzv) viremia and symptoms of herpes zoster after transplantation. viremia was demonstrated by testing peripheral blood mononuclear cells using polymerase chain reaction and was documented in 19% of 37 patients. when reactivation was defined as herpes zoster and/or subclinical vzv viremia, 41% of vzv-seropositive bmt recipients experienced vzv reactivation. none of 12 patients tested before vzv reactiva ... | 1992 | 1309369 |
| activation of lymphocytes by varicella-zoster virus (vzv): expression of interleukin-2 receptors on lymphocytes cultured with vzv antigen. | the expression of human leukocyte antigen (hla-dr) and interleukin-2 receptor (il-2r; alpha and beta subunits) was significantly increased in peripheral blood mononuclear cells (pbmc) from varicella-zoster virus (vzv)-seropositive donors when pbmc were cultured with vzv antigen for 6 days. the increased expression of hla-dr and il-2r was observed in both cd4+ and cd8+ lymphocytes, which suggests that both types of lymphocytes from vzv-seropositive donors were activated when pbmc were cultured wi ... | 1992 | 1309371 |
| investigation of varicella-zoster virus infection by polymerase chain reaction in the immunocompetent host with acute varicella. | | 1992 | 1309373 |
| viremic phase in a leukemic child after live varicella vaccination. | | 1992 | 1309394 |
| monoclonal antibodies for the identification of herpesvirus simiae (b virus). | to differentiate between b virus and hsv isolates from monkeys and man monoclonal antibodies (mabs) were produced to herpesvirus simiae (b virus) and herpes simplex type 1 and 2 (hsv-1 and hsv-2). mabs were tested by indirect immunofluorescence (ifat) for reactivity against herpesviruses from asiatic monkeys (b virus), african monkeys (sa 8 virus), and man (hsv-1, hsv-2, varicella-zoster virus, cytomegalovirus, and epstein-barr virus). mabs could be divided into groups a-e displaying specific re ... | 1992 | 1314049 |