| sensitivity of a radioimmunoassay method for detection of certain viral antibodies in sera and cerebrospinal fluids. | an indirect solid-phase radioimmunoassay (ria) was applied to titration of serum and cerebrospinal fluid (csf) antibodies against a variety of viruses including rubella, mumps, measles, herpes simplex, varicella-zoster, and vaccinia. the test used fixed, virus-infected cells as a source of antigen, and conditions for optimal production of viral antigen were determined for each virus-host cell system. in acute, uncomplicated viral infections, sera taken 2 to 5 days after onset generally had low h ... | 1976 | 187618 |
| varicella-zoster antibodies in patients with hodgkin's disease. | in an endeavour to find an explanation for th raised incidence of herpes zoster in hemoblastoses, serum samples of 50 patients with histologically confirmed hodgkin's disease and 80 control sera of normal persons of similar age groups were tested for the presenchods of indirect hemagglutination (ih), complement fixation (cf), and immunodiffusion (id). the geometric mean titer of ih antibodies and the rate of positive id results were significantly higher in the patients' group. the geometric mean ... | 1976 | 187967 |
| concurrent smallpox and chickenpox. | three patients showing smallpox- and chickenpox-like lesions simultaneously were investigated virologically. both infections were confirmed in the laboratory and, in one case, by electron microscopy. | 1976 | 188559 |
| [pathology and pathogenesis of varicella and zoster (author's transl)]. | | 1976 | 189104 |
| virus antibody levels in iga deficiency. | iga-deficient blood donors and their age- and sex-matched controls were compared for the occurrence of complement-fixing antibodies in serum against several viruses. the level in the iga-deficient persons was slightly higher against several respiratory pathogens (adenoviruses, type b influenza virus, parainfluenza virus, and respiratory syncytial virus) that give rise to localized infections, and against coxsackie b group of viruses. no corresponding difference was observed in mumps, varicella, ... | 1976 | 189383 |
| herpes zoster and impaired cell-associated immunity to the varicella-zoster virus in patients with hodgkin's disease. | thirty-two patients with hodgkin's disease and 12 normal donors were studied for their in vitro lymphocyte responsiveness to a membrane-associated varicella-zoster (vz) antigen. when compared to the normal donors, patients with hodgkin's disease in whom radiotherapy was recently completed and those with active, recurrent disease had markedly impaired cell-associated immunity to vz antigen. in addition, there was a suggestion that patients in long-term remission who had received primary combined ... | 1977 | 189604 |
| solid-phase radioimmunoassay of herpes simplex virus igg and igm antibodies. | a solid-phase radioimmunoassay for detection of herpes simplex virus-specific igg and igm antibodies in human serum specimens is presented. virus antigen is adsorbed on polystyrene balls and antibodies which attach to the antigen are detected by 125i-labeled antihuman-gamma or antihuman-mu immunoglobulins. a total of 76 specimens have been tested. the appearance of virus-specific igg and igm antibodies in primary herpetic infections was readily demonstrated. when serum samples from patients with ... | 1977 | 190320 |
| a candidate vaccine for chickenpox. | | 1976 | 190323 |
| chickenpox vaccine. | | 1976 | 190324 |
| commentary: protection against varicella. | | 1977 | 190580 |
| protection against varicella in family contacts by immediate inoculation with live varicella vaccine. | a live varicella vaccine (oka strain) was given to susceptible household contacts of varicella to test the protective efficacy of the vaccination. twenty-six contacts of 21 families were vaccinated, usually within three days after onset of the index cases. none of the vaccinated children developed clinical symptoms of varicella. eighteen of 24 sera obtained before vaccination were found to be seronegative by complement fixation and neutralization tests. seroconversion was observed in all of the ... | 1977 | 190583 |
| protective efficacy of vaccination in children in four episodes of natural varicella and zoster in the ward. | it was previously reported that a live varicella vaccine (oka strain) has been developed and that the immediate vaccination of hospitalized children was effective for prevention of spread of varicella in a ward. six to nine months later, there were four separate episodes of varicella and zoster in the same ward. eighteen children (11 with nephrotic syndrome, 6 with nephritis, and 1 with hepatitis) with no history of varicella were inoculated with a live vaccine before or immediately after admit ... | 1977 | 190584 |
| [sulphated glycosaminoglycans as virus inhibitors. 4th communication: clinical aspects of zoster with the proposal of a new treatment (author's transl)]. | on the base of plaque inhibition tests in at least three virus-host-systems and successful treatment of mice with experimentally induced yellow fever encephalitis a well known sulphated glycosaminoglycan (gagps) "l5" was used as therapeutic agent in cases of zoster infection in man. the material was applied as 1% solution in water continuously on lint and rewettet for several days until nearly complete healing was achieved. the clinical course of 18 patients of former years (12 women, 6 men) was ... | 1977 | 190822 |
| varicella and herpes zoster: comparisons in the old and young. | | 1977 | 191332 |
| 2-substituted derivatives of 9-alpha-d-arabinofuranosyladenine and 9-alpha-d-arabinofuranosyl-8-azaadenine. | 2-substituted derivatives of 9-alpha-d-arabinofuranosyladenine were prepared via the fusion of tetra-o-acetyl-alpha-d-arabinofuranose with 2,6-dichloropurine followed by stepwise displacement of the chloro groups. a different approach, the reaction of 2,3,5-tri-o-benzoly-d-arabinofuranosyl bromide with 2,6-bis(methylthio)-8-azapurine in refluxing toluene in the presence of molecular sieve followed by stepwise reaction of the blocked nucleoside with methanolic ammonia and then other nucleophiles, ... | 1977 | 191611 |
| induction of deoxypyrimidine kinase activity in human embryonic lung cells infected with varicella-zoster virus. | deoxypyrimidine kinase (deoxythymidine [tdr] kinase and deoxycytidine kinase) activity was induced in human embryonic lung cells after infection with varicella-zoster virus (vz virus). increased enzyme activity was also produced by using cell-associated virus as inoculum instead of cell-free virus. anti-vz virus serum inhibited both the appearance of cytopathic effect and the induction of enzyme activity. the induced tdr kinase activity was more thermostable than that induced by herpes simplex v ... | 1977 | 191646 |
| herpes zoster ophthalmicus. | herpes zoster ophthalmicus is not an uncommon disease and is more prevalent among debilitated and seriously ill patients. it is caused by the same virus causing varicella. the exact trigger mechanism is unknown, as well as much of the pathogenesis. the disease is more uncommon among the elderly and usually runs a benign course. approximately 50% of the patients develop ocular complications ,the most frequent of these being keratitis, iritis, secondary glaucoma and extraocular muscle involvement. ... | 1976 | 191772 |
| viral infections in renal transplant donors and their recipients: a prospective study. | the majority of renal allograft recipients develop viral infections, usually with cytomegalovirus (cmv). their source if virus has not been defined clearly; one possibility if the transplanted kidney itself. to explore this, prospective viral studies were performed on 28 living related donor-recipient pairs. donors did not have clinical illnesses and viruses were not recovered from throat, urine, or renal tissue, but five (18%) had fourfold rises in antibody titers to herpes group viruses. durin ... | 1977 | 191948 |
| [prevention and therapy of viral diseases with special reference to interferon]. | human leukocyte interferon (hli) was used for treatment of human diploid fibroblasts before and after infection with vaccinia virus, herpes simplex virus type 1 (hsv 1), herpes simplex virus type 2 (hsv 2), and varicella zoster virus (vzv). vero cells were infected with medical lake macaque herpes virus (mlmv), and treated with hli in the same way. in all of these systems hli exhibited an antiviral effect when administered before infection, and this effect could be increased by additional hli tr ... | 1977 | 192653 |
| antigenic relationships among several simian varicella-like viruses and varicella-zoster virus. | cross-neutralization and complement fixation tests demonstrated the immunological identity of the delta herpesvirus, the 592s virus, the liverpool vervet monkey virus, the herpesvirus of patas monkeys, and the medical lake macaque virus. these viruses were isolated from diverse outbreaks of varicella-like disease in simians and from various simian species. all of the simian viruses were shown to be related to human varicella-zoster (v-z) virus, as evidenced by the fact that immunization of monke ... | 1977 | 192676 |
| complement-fixing reactivity of varicella-zoster virus subunit antigens with sera from homotypic infections and heterotypic herpes simplex virus infections. | various subunit antigens of varicella-zoster (v-z) virus were examined for complement-fixing (cf) activity with sera from homotypic infections and from herpes simplex virus (hsv) infections in which a cf antibody titer rise was demonstrated with crude v-z antigen. the subunit antigens included nucleocapsids, envelopes, a soluble antigen produced from infected culture fluids by sucrose density gradient centrifugation, a soluble antigen produced by reducing the volume of clarified infected culture ... | 1977 | 192677 |
| the effect of phosphonoacetic acid on the in vitro replication of varicella-zoster virus. | phosphonoacetic acid (paa) was found to inhibit in vitro varicella-zoster virus (vzv) replication. at 100 microng/ml, paa blocked the development and spread of vzv cytopathology in both growing and contact-inhibited cultures. formation of virus plaques by infected cells and cell-free virus was effectively blocked at concentrations as low as 25 microng/ml. the development of nuclear and cytoplasmic virus antigens was also inhibited by paa. inhibition by paa suggests that vzv dna replication, like ... | 1977 | 192695 |
| clinical and pathogenetic studies of medical lake macaque virus infections in cynomolgus monkeys (simian varicella). | the medical lake macaque (mlm) virus produced varicelliform eruptions in cynomolgus monkeys. not all experimentally infected monkeys developed overt disease; viremia was found, and specific antibodies were detected. specific lesions were found in skin, lymph nodes, and spleen. focal inflammatory lesions were present in liver, pancreas, and lung (after intratracheal instillation of virus). mlm virus was recovered from these and other organs. the temporal movements of mlm virus in and out of prima ... | 1977 | 192806 |
| a longitudinal study of varicella-zoster virus infections in renal transplant recipients. | a serum bank maintained for renal transplant recipients allowed for a longitudinal study of antibody responses before and after herpes zoster. renal transplant recipients without herpes zoster served as controls. antibody responses to varicella-zoster virus, herpes simplex virus type 1, and cytomegalovirus were measured. the serological responses following herpes zoster were prompt and sustained (in the majority of cases), transient, or not present at all. zoster without an eruption occurred (ap ... | 1977 | 192807 |
| cellular immune responses to herpesviruses during treatment with adenine arabinoside. | thirteen patients severely infected with herpesvirus were treated with intravenous adenine arabinoside (ara-a), and two patients received placebo therapy. blastogenic and cytotoxic responses specific for the virus infecting each patient were determined before, during, and after treatment. blastogenic responses to three mitogens (phytohemagglutinin, pokeweed, and concanavalin-a) were examined, as were titers of viral antibody. in vitro responses during and after treatment with ara-a were unchange ... | 1977 | 192808 |
| cellular immunity and herpesvirus infections in cardiac-transplant patients. | we observed severe infection with herpes simplex virus in cardiac-transplant patients despite their high serum antibody levels to this virus. therefore, we sought to correlate clinical susceptibility to two herpesvirus (simplex and zoster) infections with specific cellular immunity, assessed by the transformation and interferon responses of peripheral blood mononuclear cells to heat-inactivated antigens. transformation and interferon response to herps simplex virus was maximally depressed immedi ... | 1977 | 193008 |
| herpesvirus group antibodies in children with hodgkin's disease. | during the period of three years ((1972-1974), serum samples from 60 patients (children and adolescents) with lympho-hematopoietic system diseases were examined for antibodies to all four human herpesviruses. among these were 26 active hodgkin's disease (ahd) patients and 6 hd patients with a minimum five years' remission. simultaneously matched controls (age, sex) of ahd patients were examined. antibody levels against the viral capsid antigen of epstein-barr virus (ebv/vca) in ahd patients were ... | 1977 | 193463 |
| complement fixing antibody to varicella-zoster virus in different age groups and after zoster. | the titer of complement fixing antibody to varicella-zoster virus was studied in sera from 215 normal persons living in padua and its province and from 39 zoster patients. about 74% of sera from normal persons aged 21-80 years had antibody titers larger than or equal to 1/4. lower titers were present in the age groups 1-20 years and 81-90 years. sera from zoster patients had high titers from the second week following the onset of the rash. they were still comparatively high until the fifth month ... | 1977 | 193530 |
| immune adherence hemagglutination: further observations on demonstration of antibody to varicella-zoster virus. | the immune adherence hemagglutination test for measurement of antibody to varicella-zoster (v-z) virus is well suited to performance in a routine serology laboratory. this test is useful in assessing susceptibility to varicella, measuring antibody to v-z virus in globulin preparations, and evaluating some effects of passive immunization. since the complement-fixation test for antibody to v-z virus lacks sensitivity and the fluorescent antibody to membrane antigen test is not readily available, ... | 1977 | 193997 |
| determination of neutralizing antibody and igg antibody to varicella-zoster virus and of igg antibody to membrane antigens by the immunoperoxidase technique. | | 1977 | 194001 |
| [significance of diabetes mellitus in the activation of the varicella zoster virus (author's transl)]. | eruptive herpes zoster infection (vzv) and its primary and secondary diseases are reported in 28 patients aged between 25 and 85 years. in 2 cases, malignant primary diseases were found. in 16 patients, a disorder of glucose utilization was diagnosed, 8 of them accompanied by a disorder of fat metabolism and 5 by a hyperuricemia. in one case a severe encephalomyelitis was observed. in 2 patients the activation of the vzv infection was related to the cytostatic or immunosuppressive therapy of a g ... | 1977 | 194145 |
| [complement fixation antibodies against varicella zoster virus in mexico city]. | | 1976 | 194343 |
| viral infections in kidney donors and recipients: a prospective study. | | 1977 | 194367 |
| prevention or modification of varicella using zoster immune plasma. | zoster immune plasma (zip) was given to 31 susceptible immunocompromised children one to seven days (median, two days) following household, playmate, or hospital exposures to varicella. the average amount of zip transfused was 7 ml/kg. twenty-one children did not develop varicella or persistent antibodies to varicella-zoster virus (vzv). eight (26%) of the 31 contracted clinical varicella. seven cases were mild, but in one child, who was given zip seven days after exposure, visceral disease deve ... | 1977 | 194476 |
| [herpesvirus antibodies in hodgkin's disease and some lympho-hematopoietic diseases in children and adolescents]. | | 1977 | 194715 |
| multiplicity-dependent replication of varicella-zoster virus in interferon-treated cells. | the inhibitory effects of interferon (if) on the replication of varicella-zoster (vz) virus in human foreskin fibroblast (hff) cultures inoculated with infected cells or with cell-free virus were assayed by measuring (1) yields of infected cells, (2) plaques, (3) microfoci and (4) cytopathic effects. more if was needed to reduce yields of infected cells at high input multiplicities of challenge than at low input multiplicites, and still more if was needed to prevent cytopathology due to vz virus ... | 1977 | 195010 |
| a novel approach to study the dna of herpes zoster virus. | herpes zoster virus dna was isolated from infected human embryo lung cells because it is released into the "hirt supernatant". the buoyant density of the virus dna was found to be slightly higher than that of cellular dna. the molecular weight of this dna was estimated to be 92 x 10(6) daltons by cosedimentation with t4 dna in neutral sucrose gradients. as with the dna of other herpesviruses, the dna of herpes zoster virus is fragmented when denatured under alkaline conditions and is therefore " ... | 1977 | 195912 |
| [prognosis of prenatal varicella-zoster-infections in relation to their onset during pregnancy (author's transl)]. | 7 children were observed, whose mothers had varicella-zoster-virus-infection. 3 of these children developed postnatal herpes zoster without varicella in their history; 1 child had varicella in the neonatal period. there are indications that primary infection with varicella-zoster-virus during the first four months of pregnancy may cause deformities in the child; the same during the last five days of pregnancy increases the risk of varicella with a complicated course in the newborn. independent o ... | 1977 | 196188 |
| [therapy of herpes zoster with sodium pentosan polysulfate]. | | 1977 | 196192 |
| simple mathematical deductions in the seroepidemiology of viral infections. i. herpesvirus group (herpesvirus hominis, varicella-zoster virus, cytomegalovris, epstein-barr-virus). | large samples of nonselected persons collected in south-west germnay were investigated for the prevalence of serum antibodies to the human herpesviruses hsv, vzv, cmv and ebv. according to "catalytic models", which compare the infection spread to simple chemical reactions of molecules, a mathematical approximation of the serum surveys was performed. through a new deduction of the exponential function y = k (l - e-r+) a simple way was found to estimate the annual attack rates in percent of the su ... | 1977 | 196453 |
| indirect immunofluorescence detection of human igm and igg antibodies against herpes simplex virus type 1 induced cell surface antigens. | an indirect immunofluorescence method, based on the use of infected hela cell coverslip cultures was developed to demonstrate human igm and igg class antibodies against herpes simplex virus (hsv) type 1 induced cell surface antigens. a total of 35 specimens from 20 patients have been tested; including patients with a clinical diagnosis of hsv type 1 or type 2 primary infection, patients with recurrent hsv infections, patients without any hsv infections, and patients with varicella-zoster virus ( ... | 1977 | 196479 |
| differential effect of arabinofuranosylthymine of the replication of human herpesviruses. | the thymidine analog 1-beta-arabinofuranosylthymine (ara-t) has previously been found to selectively inhibit herpes simplex virus replication. at a relatively nontoxic conentration (50 microgram/ml), ara-t reduced herpes simplex virus yields by 4 to 5 log10. ara-t was also effective in inhibiting the replication of varicellazoster virus (vzv) in vitro in human embryo fibroblasts, completely preventing vzv-specific cytopathic effects. the inhibition of vzv was reversible upon drug removal at 48 h ... | 1977 | 197264 |
| varicella-zoster virus vaccine. | | 1977 | 197280 |
| [pathogenesis and topography of herpes zoster in childhood and in adult age]. | | 1977 | 197719 |
| the herpesvirus group. | several agents in the herpesvirus group are known to infect man. they cause a wide variety of conditions, ranging from coldsores to chickenpox and shingles. at the same time a number of the herpesviruses have been linked with malignant diseases in both lower animals and man. | 1977 | 198052 |
| antibody to varicella-zoster virus-induced membrane antigen: immunofluorescence assay using monodisperse glutaraldehyde-fixed target cells. | a sensitive and reproducible technique was developed for the detection of antibody to varicella-zoster virus-induced membrane antigen (vzma) by immunofluorescence. controlled trypsinization and glutaraldehyde fixation were employed to prepare a monodisperse suspension of noninfectious vzma-positive target cells that can be stored indefinitely at -72 degrees c. a microtiter immunofluorescence assay utilizing these target cells was shown to provide a sensitive and specific means for the detection ... | 1977 | 198487 |
| prospective study of prevalence, incidence, and source of herpesvirus infections in patients with renal allografts. | the prevalence, incidence, and source of infections with different types of herpesviruses were determined prospectively for 25 persons undergoing hemodialysis, 30 allograft recipients, and 16 kidney donors. the prevalence of prior infections with cytomegalovirus (cmv), herpes simplex virus (hsv), and epstein-barr virus (ebv) was high (72%-100%) and was similar for healthy persons and those with renal failure. the incidence of infections in patients undergoing hemodialysis was no greater than tha ... | 1977 | 198488 |
| a viremic phase for herpes zoster in children with cancer. | eight childhood cancer patients with herpes zoster were serially tested for the presence of varicella-zoster virus in blood. cell cultures of leukocyte-rich plasma from four patients were positive for the virus. in this study viremia was clearly related to dissemination of dermal lesions-the spread of zoster lesions outside an infected dermatome. the child with the longest viremic phase, five days, had the longest and most severe course of skin dissemination, as well as biochemical evidence of h ... | 1977 | 198521 |
| comparison of the dnas of varicella-zoster viruses isolated from clinical cases of varicella and herpes zoster. | | 1977 | 199993 |
| analysis by restriction enzyme cleavage of human varicella-zoster virus dnas. | | 1977 | 199994 |
| acute peripheral facial palsy. part of a cranial polyneuropathy? | in 14 of 16 consecutive patients with acute peripheral facial palsy, one or more (up to four) other nerves were involved. the nerves affected in addition to the facial nerve were as follows: trigeminal (ten patients), vestibular (eight), cochlear (six), vagus (one), and upper cervical (five). virus was not isolated from any of the patients. a fourfold increase or decrease in complement-fixing antibody titers was present in eight patients (in four, varicella-zoster; in one, varicella-zoster and m ... | 1977 | 200210 |
| bell's palsy and herpes simplex. | | 1977 | 200303 |
| diagnostic skin test reactions with varicella virus antigen and clinical application of the test. | varicella virus antigen was prepared and used in skin testing of 75 children one to 17 years old. results of skin tests were analyzed in relation to history of varicella, presence of absence of neutralizing antibody, and susceptibility to clinical varicella. all 22 children with no history of varicella and no neutralizing antibody were negative in the skin test when an erythematous change of greater than or equal to 5 mm in diameter was taken as a positive result. of the 53 children with neutral ... | 1977 | 200680 |
| [varicella virus and herpes zoster]. | | 1977 | 200776 |
| [methods for the rapid diagnosis of herpes simplex using the indirect hemagglutination reaction]. | a method for preparation of an erythrocyte immunoglobulin herpes preparation for the indirect hemagglutination test (iha) is described. a high specificity and sensitivity of this test and the preparation has been demonstrated. the results of the use of iha with this preparation for the detection of herpes simplex virus in specimens from patients are presented. | 1977 | 201105 |
| varicella-zoster infections. | | 1978 | 202811 |
| [cephalic zoster with involvement of the 5th, 7th, 8th, 9th and 10th cranial nerves]. | a case of cephalic zoster with involvement of the 5th, 7th, 8th, 9th and 10th left cranial nerves is described. the anatomopathological findings are surveyed. these show that lesions are often found in several areas of the nervous system. the pathogenesis of these forms is examined, with particular reference to the mechanism of involvement of several cranial nerves. it is felt that this is primarily due to reactivation of the virus in several ganglia. | 1977 | 202894 |
| application of a live varicella vaccine in children with acute leukemia or other malignant diseases. | a live varicella vaccine was used in 11 susceptible children in remission from acute leukemia, ten of whom had been in remission for six months or less, and in 6 children with neuroblastoma and retinoblastoma. in the immunological checkup before vaccination, most of them showed a positive reaction in the skin tests with dinitrochlorobenzene, phytohemagglutinin, purified protein derivative, and viral antigens. leukopenia (three cases, less than 3,000/cu mm) and decreased igg level (two cases, 380 ... | 1977 | 202915 |
| clinical and serologic testing of a live varicella vaccine and two-year follow-up for immunity of the vaccinated children. | a live varicella vaccine derived from the oka strain was given on 181 children who had no history of varicella and were seronegative by complement fixation (cf) and neutralization (nt) tests; 125 children were hospitalized and 54 were receiving steroid therapy. overall, seroconversion was achieved in 85.1% of the children by the cf test and in 97.8% by the nt test. clinical reaction consisting of mild fever and rash appeared in only two children. one hundred seventy-nine of the vaccinated childr ... | 1977 | 202916 |
| varicell vaccine at the crossroads. | | 1977 | 202918 |
| varicella-zoster virus: isolation and propagation in human melanoma cells at 36 and 32 degrees c. | cell lines derived from human malignant melanoma tumors are susceptible to infection with varicella-zoster virus (vzv). within 5 days after inoculation of vesicular fluid, cytopathic changes appeared in melanoma cell monolayer cultures that were incubated at either 36 or 32 degrees c. the vzv isolates at the two temperatures were serially propagated by passage of trypsin-dispersed infected cells. a plaque assay was developed utilizing melanoma cell monolayers overlaid with nutrient medium contai ... | 1978 | 203532 |
| quantitation of antibodies to varicella-zoster virus by immune adherence hemagglutination. | immune adherence hemagglutination was compared with the complement fixation test as a means of measuring antibodies to varicella-zoster virus. analysis of acute- and convalescent-phase sera from patients infected with varicella-zoster or with herpes simplex virus showed the immune adherence hemagglutination test to be more sensitive than the complement fixation test, and greater cross-reactivity between the two viruses appeared to be associated with the increased sensitivity. the two assay metho ... | 1978 | 203604 |
| viral antibodies in cerebrospinal fluid of multiple sclerosis and control patients: comparison between radioimmunoassay and conventional techniques. | cerebrospinal fluid antibodies to measles, rubella, vaccinia, herpes simplex, and varicella-zoster viruses in four patient study groups (clinically definite multiple sclerosis [ms], early probable ms, optic neuritis, and control patients with other neurological diseases) were assayed by radioimmunoassay, complement fixation, hemagglutination-inhibition, or complement-enhanced plaque reduction methods. antibodies were more frequently found and at higher dilutions by radioimmunoassay than by other ... | 1978 | 203605 |
| varicella-zoster virus vaccine. | | 1978 | 203727 |
| [viral immunofluorescent technic--virus]. | | 1977 | 203735 |
| susceptibility of primate diploid cells to human herpesviruses. | | 1977 | 203826 |
| efficacy of zoster immunoglobulin in prophylaxis of varicella in high-risk patients. | during a period of 2 1/2 years 190 children have been prophylactically treated with zoster immunoglobulin in norway. information on 130 (68%) of these children was obtained. this group included patients suffering from leukemia, lymphoma, and other malignant disorders, and patients with autoimmune diseases, with impaired immune mechanisms or with for other reasons increased frequency of infections, as well as premature and weak newborns, and infants born to mothers who developed varicella during ... | 1978 | 204151 |
| [effect of varicella-zoster virus on cultured human cornea fibroblast (author's transl)]. | | 1977 | 204175 |
| varicella-zoster virus infection of human brain cells and ganglion cells in tissue culture. | the growth of varicella-zoster virus (vzv) in cultures of human brain (hb) and human ganglion (hg) cells was compared to vzv growth in human fibroblasts. infected cultures were monitored by histologic, electron microscopic (em), and virologic techniques. two to three days after vzv infection of all cell cultures at a multiplicity of infection (moi) of 0.1, a multifocal cytopathic effect (cpe) developed. cpe was characterized by multinucleated cells and virus-specific intranuclear inclusions as d ... | 1978 | 204267 |
| immune adherence hemagglutination test applied to the study of herpes simplex and varicella-zoster virus infections. | the immune adherence hemagglutination (iaha) test has been used successfully to detect antibody to herpes simplex (hs) virus and varicella-zoster (v-z) virus. comparative studies between the complement-fixation (cf) test and the iaha test revealed that, in most cases, the iaha test was more sensitive than the cf test. furthermore, diagnosis on the basis of a fourfold change in antibody titer was made more rapidly by the iaha test. the iaha test was found to be a very simple and practical techniq ... | 1978 | 204662 |
| hyporesponsiveness of lymphocytes to virus antigens in rheumatoid arthritis. | the immune response of peripheral blood lymphocytes to measles, rubella, parainfluenza types 1, 2, and 3 rna virus antigens and to varicella-zoster and herpes virus type 1 dna virus antigens was evaluated in 14 patients with rheumatoid arthritis (ra) and 14 matched controls by assessing 3h-thymidine incorporation. the results demonstrated hyporesponsivenss of lymphocytes from ra patients to virus antigens and phytohemagglutinin (pha), which did not appear to be nonspecific because of a lack of c ... | 1978 | 205223 |
| evaluation of zoster immune plasma. treatment of cutaneous disseminated zoster in immunocompromised patients. | zoster immune plasma (zip) was evaluated for treatment of cutaneous disseminated zoster in immunocompromised hosts. twenty patients were studied: 13 were enrolled in a double-blind protocol, five received zip under an open protocol, and two were observed without receiving a transfusion. in the double-blind study, eight patients actually received zip; five were given plasma lacking varicella-zoster virus antibodies (control plasma). the clinical course of zoster in the group given zip was the sam ... | 1978 | 205687 |
| [method of quantitative determination of antibodies to varicella-zoster virus]. | | 1978 | 206024 |
| selective impairment of lymphocyte reactivity to varicella-zoster virus antigen among untreated patients with lymphoma. | herpes zoster is a frequent complication of lymphoreticular malignancy. in this study two assays of in vitro cellular immune response to varicella-zoster virus (vzv) antigen, lymphocyte transformation and interferon production, were performed in normal subjects with recent and remote vzv infection. the responses of patients with lymphoma were measured before treatment and during long-term remission and then compared with those of normal subjects. despite levels of antibody to vzv that were equiv ... | 1978 | 207782 |
| a practical method for preparation of varicella-zoster immune globulin. | outdated blood from blood banks in massachusetts was screened for complement-fixing antibody to varicella-zoster virus (vzv). approximately 15% of the plasma units had a titer greater than or equal to 16, and one-half of these had a titer of greater than or equal to 32. plasma units with titers of cf antibody to vzv of greater than or equal to 16 were pooled. this pool had a cf antibody titer of 32 and a titer of fluorescent antibody of 64. varicella-zoster immune globulin was prepared from the ... | 1978 | 207788 |
| varicella-zoster viremia. | | 1978 | 207842 |
| purification and characterization of varicella-zoster virus-induced dna polymerase. | infection of wi-38 human fibroblasts with varicella-zoster virus led to the stimulation of host cell dna polymerase synthesis and induction of a new virus-specific dna polymerase. this virus-induced dna polymerase was partially purified and separated from host cell enzymes by deae-cellulose and phosphocellulose column chromatographies. this virus-induced enzyme could be distinguished from host cell enzyme by its chromatographic behavior, template specificity, and its requirement of salt for maxi ... | 1978 | 207886 |
| what you should know about new and current viral vaccines. | | 1978 | 207966 |
| [rapid diagnosis of infections caused by the chickenpox-herpes zoster viruses]. | a diagnostic preparation for the indirect hemagglutination test (iha) was obtained by sensitization of fixed tannin-treated sheep erythrocytes with igg-fractions from human herpes zoster convalescent sera. a high specificity of the preparation was established in comparative experiments. it could detect the varicella-herpes-zoster virus antigen in 100% of specimens from patients. the iha test with this erythrocyte diagnostic preparation is simple, economic, gives the results within 1-1 1/2 hours ... | 1978 | 208309 |
| 5,6-dihydro-5-azathymidine: in vitro antiviral properties against human herpesviruses. | 5,6-dihydro-5-azathymidine (dhadt), a novel water-soluble nucleoside antibiotic, inhibits herpes simplex virus type 1 (hsv-1) in appropriately infected cell cultures to a greater extent than herpes simplex virus type 2 (hsv-2). vaccinia virus was less susceptible than hsv-2, and pseudorabies virus yields were not reduced at the concentrations studied. plaque formation by varicella-zoster virus was suppressed by dhadt. dhadt was slightly toxic to cells at concentrations that were inhibitory for h ... | 1978 | 208459 |
| use of a live varicella vaccine to prevent the spread of varicella in handicapped or immunosuppressed children including mcls (muco-cutaneous lymphnode syndrome) patients in hospitals. | | 1977 | 208503 |
| studies on neutralization of varicella-zoster virus and serological follow-up of cases of varicella and zoster. | | 1978 | 208504 |
| cell-mediated immunity to varicella zoster virus in children being treated for cancer. | stimulation of lymphocytes by varicella-zoster virus (vzv) antigen was measured in vitro for 37 healthy adults and children and for 35 children who developed herpes zoster or varicella while receiving anticancer therapy. for 35 of the control group the history of varicella infection correlated with the in vitro response of lymphocytes to vzv antigen. a specific lymphocyte response was observed following 32 of the 37 episodes of vzv infection in the 35 children with malignancy. re-evaluation 7--1 ... | 1978 | 208747 |
| cytologic examination and viral and bacterial culture in herpes simplex, herpes zoster, and varicella. | cytologic examination of epithelial cells from the base of vesicles, virus isolation, and bacterial culture were carried out in thirty-one patients with herpes simplex, in eleven patients with herpes zoster, and in three patients with varicella. determination of herpes simplex complement fixation reaction was made in the patients with herpes simplex. cytologic manifestations consistent with herpes were found 65 percent of patients with herpes simplex, while herpesvirus hominis was isolated in 77 ... | 1978 | 208820 |
| infections and other maternal factors as risk indicators for congenital malformations: a case-control study with paired serum samples. | an obstetric population of 48,000 individuals was prospectively followed up for evidence of possible teratogenic factors that might be associated with congenital malformations. serum samples from 274 mothers of defective children and from paired controls were collected during early pregnancy and approximately one month after delivery and tested for antibodies against ten different viruses, mycoplasma pneumoniae, and toxoplasma. these data were supplemented with clinical information on infections ... | 1978 | 209394 |
| seroepidemiologic aspects of varicella zoster virus infections in an israeli jewish population. | sera from 872 healthy subjects among the jewish population of israel were examined for antibodies to varicella zoster virus (vzv) by a simplified technique for the detection of immunofluorescent antibody to membrane antigen. the difference in the geometric mean titer of antibodies to the virus among the the different age groups was highly significant (p less than 0.0001). the highest titers were found in the five-to-seven-years and 21-to-30-years age groups. in 211 subjects, aged 17 to 40 years, ... | 1978 | 210147 |
| overview and horizons in prevention of some human infectious diseases by vaccination. | the present measles problem in the united states, an estimated 918,500 cases in 1977, is attributed to the failure of the 14-year vaccination program to immunize enough children to prevent continued circulation of the virus and recurrent outbreaks. a new strategy for rapidly overcoming this problem is recommended. there appears to be no current congenital rubella syndrome problem against which the rubella vaccination program in the united states is directed. however, the continued annual infecti ... | 1978 | 210652 |
| varicella-zoster virus. prospects for active immunization. | a live attenuated varicella-zoster (v-z) virus vaccine has been developed and tested by dr. m. takahashi and his colleagues in japan. this vaccine appears to prevent varicella and is associated with minimal side effects even in patients at high risk to develop severe varicella. antibody to v-z virus appears after v-z vaccination. this antibody has been detected by a variety of serologic technics, and it has been demonstrated to persist for as long as two years after vaccination. thus far, v-z va ... | 1978 | 210654 |
| nih conference. herpes zoster-varicella infections in immunosuppressed patients. | | 1978 | 210697 |
| comparison of wi-38, mrc-5, and imr-90 cell strains for isolation of viruses from clinical specimens. | with the diminishing supply of the human fetal lung wi-38 cell strain, a replacement for viral isolation is needed. two candidates are the human fetal lung strains mrc-5 and imr-90. a comparison of wi-38, mrc-5, and imr-90 was performed to evaluate efficiency and speed of viral isolation, clarity of cytophatic effect, and ease of growing the cells. the inocula were clinical specimens rather than tissue culture-adapted isolates. frozen samples of 46 specimens that had previously yielded an isolat ... | 1978 | 211143 |
| antibody to varicella zoster virus in low-birth-weight newborn infants. | | 1978 | 211219 |
| [varicella vaccine]. | | 1978 | 211282 |
| neutralization test for varicella virus on vero cell monolayer. | | 1977 | 211308 |
| summary of a workshop on new and useful methods in viral diagnosis. | | 1978 | 212491 |
| mink lung cells: a non-primate cell line highly susceptible for varicella-zoster virus. | mink lung cells (mvilu) are highly susceptible to varicella-zoster virus (vzv). the titres of cell-free vzv suspensions reached 1.0 x 10(7) p.f.u./ml at 3 days post-infection, with subsequent cell degeneration, if mvilu cells were infected with a multiplicity of infectious virus of 0.01 p.f.u./cell. in contrast, during the same period and under the same conditions the titres of cell-free vzv were 10(2) to 10(3) times lower when grown on human foreskin fibroblasts. a fast and reliable plaque assa ... | 1978 | 212517 |
| promising new antiherpes agent being tested in humans. | | 1978 | 212617 |
| selective inhibition of the replication of varicella-zoster virus by 5-halogenated analogs of deoxycytidine. | | 1977 | 212983 |
| phosphonoacetic acid in the treatment of simian varicella. | phosphonoacetic acid inhibited replication of simian varicella virus (delta herpesvirus) in tissue culture. the drug was tested in patas monkeys 40 h after infection with delta herpesvirus. a total of 200 mg/kg per day was given intramuscularly, divided into two doses every day for a total of 10 days. the treated monkeys were protected from clinical illness, and delta herpesvirus was not recovered from their lymphocytes. complement-fixing and neutralizing antibody titers were significantly lower ... | 1978 | 213014 |
| bell's palsy and herpes simplex. | | 1978 | 213158 |
| use of live varicella vaccine in children with acute leukemia. | seven children with acute leukemia were given a live attenuated varicella vaccine and successfully seroconverted with minimal clinical reactions. one of them was vaccinated immediately after the contact with natural varicella and successfully prevented from natural infection. | 1978 | 213857 |