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evaluation of glycoprotein e subunit and live attenuated varicella-zoster virus vaccines formulated with a single-strand rna-based adjuvant.varicella-zoster virus (vzv), a human alphaherpesvirus 3, elicits both chickenpox and shingles and/or postherpetic neuralgia. a live attenuated vaccine (lav) and glycoprotein e (ge) subunit vaccine were developed to prevent vzv-induced diseases. we recently reported that single-strand rna (ssrna) based on the intergenic region of the internal ribosome entry site of cricket paralysis virus (crpv) is an effective adjuvant for protein-based and virus-like particle-based vaccines. here, chinese hams ...202032167678
rare case of post-varicella membranoproliferative glomerulonephritis presenting with massive proteinuria.chicken pox caused by varicella zoster virus is usually a self-limiting disease causing rare life-threatening complications. involvement of the kidneys is infrequent during the course of the illness. literature shows rare reports of acute glomerulonephritis following varicella infection. we report a case of 16-year-old boy presenting with anasarca with characteristic healed rashes of chicken pox. his urinalysis revealed a 'massive' nephrotic range proteinuria (16 g/24 hours), gross hematuria and ...202032169983
synthesis of organotin polyamine ethers containing acyclovir and their preliminary anticancer and antiviral activity.organotin polyamine ethers containing acyclovir in their backbone were synthesized in moderate to high yield employing the aqueous interfacial polycondensation system. the products are high molecular weight polymers. infrared spectroscopy of the products shows new bands characteristic of the formation of sn-n and sn-o bonds consistent with the proposed structure. maldi-tof ms below 2000 da shows the presence of organotin and acyclovir units containing these two moieties. the products show modera ...200632214932
herpes zoster and its prevention by vaccination.herpes zoster (hz; shingles) results from reactivation of varicella-zoster virus (vzv) after primary infection as varicella (chicken pox). it affects mainly older adults and people with immunocompromising diseases or treatments. the most common complication is postherpetic neuralgia (phn), which has significant adverse effects on quality of life and activities of daily living. since phn cannot be prevented once hz has occurred, and treatment is only modestly successful and is associated with sig ...202032305975
persistence of varicella-zoster virus-specific plasma cells in adult human bone marrow following childhood vaccination.childhood immunization with the live-attenuated varicella-zoster virus (vzv) vaccine induces protective immune responses. routine vzv vaccination started only 2 decades ago, and thus, there are few studies examining the longevity of vaccine-induced immunity. here, we analyzed the quantity of vzv-specific plasma cells (pcs) and cd4 t cells in the bone marrow (bm) of healthy young adults (n = 15) following childhood vzv immunization. long-lived bm resident plasma cells constitutively secrete antib ...202032321817
disseminated varicella-zoster virus infection complicated by encephalitis and ramsay hunt syndrome in an hiv patient.varicella-zoster virus (vzv) is a human α-herpesvirus which cause primary varicella infection (chicken pox) or herpes zoster infection (shingles) after reactivation of the dormant virus. vzv infection is usually self-limited but disseminated infection can be seen in immunocompromised individuals. it can also get complicated by central nervous system (cns) involvement. we describe a case of a 51-year-old male with human immunodeficiency virus (hiv) who presented with altered mental status and def ...202032699727
a novel human skin tissue model to study varicella-zoster virus and human cytomegalovirus.the herpesviruses varicella-zoster virus (vzv) and human cytomegalovirus (hcmv) are endemic to humans. vzv causes varicella (chicken pox) and herpes zoster (shingles), while hcmv causes serious disease in immunocompromised patients and neonates. more effective, less toxic antivirals are needed, necessitating better models to study these viruses and evaluate antivirals. previously, vzv and hcmv models used fetal tissue; here, we developed an adult human skin model to study vzv and hcmv in culture ...202032878893
elevated serum substance p during simian varicella virus infection in rhesus macaques: implications for chronic inflammation and adverse cerebrovascular events.varicella and zoster, produced by varicella-zoster virus (vzv), are associated with an increased risk of stroke that may be due to persistent inflammation and hypercoagulability. because substance p is associated with inflammation, hypercoagulability, and atherosclerotic plaque rupture that may contribute to increased stroke risk after vzv infection, we measured serum substance p in simian varicella virus-infected rhesus macaques. we found significantly increased and persistent serum substance p ...202032964407
identification and characterization of cd4+ t cell epitopes after shingrix vaccination.infections with varicella zoster virus (vzv) are associated with a range of clinical manifestations. primary infection with vzv causes chicken pox. the virus remains latent in neurons and it can reactivate later in life causing herpes zoster (hz). two different vaccines have been developed to prevent hz, one based on a live attenuated vzv strain (zostavax) and the other on adjuvanted ge recombinant protein (shingrix). while zostavax efficacy wanes with age, shingrix protection retains its effica ...202032999027
the tegument protein pul47 of marek's disease virus is necessary for horizontal transmission and is important for expression of glycoprotein gc.viral tropism and transmission of herpesviruses are best studied in their natural host for maximal biological relevance. in the case of α-herpesviruses, few reports have focused on those aspects, primarily because of the few animal models available as natural hosts that are compatible with such studies. here, using marek's disease virus (mdv), a highly contagious and deadly alphaherpesvirus of chickens, we analyze the role of tegument proteins pul47 and pul48 in the whole life cycle of the virus ...202032999032
varicella-zoster virus: molecular controls of cell fusion-dependent pathogenesis.varicella-zoster virus (vzv) is the causative agent of chicken pox (varicella) and shingles (zoster). although considered benign diseases, both varicella and zoster can cause complications. zoster is painful and can lead to post herpetic neuralgia. vzv has also been linked to stroke, related to giant cell arteritis in some cases. vaccines are available but the attenuated vaccine is not recommended in immunocompromised individuals and the efficacy of the glycoprotein e (ge) based subunit vaccine ...202033259590
successful oral treatment of third cranial nerve palsy and optic neuritis from neglected herpes zoster in an immunocompetent patient.herpes zoster (hz) is an acute viral eruption caused by the reactivation of varicella zoster virus (vzv), a herpes virus causing chicken pox in children. we aimed to report a 3-month neglected case of acute herpes zoster-induced third nerve palsy and optic neuritis, followed by a late-onset keratouveitis in an immunocompetent young adult.202033294726
necrotizing stomatitis in varicella zoster infection.necrotizing periodontal disease are acute periodontal conditions which can present with simple gingivitis to more complex life threatening condition where it can perforate the skin of cheek. they are found in patients with severe illness, stress and reduced immunity. the prevalence of this whole group of disease is usually very low and is stated frequently as the first manifestation in hiv infection. herpes zoster, a common dermatological condition is a secondary infection due to re-activation o ...202133594035
culture media optimization for chinese hamster ovary cell growth and expression of recombinant varicella-zoster virus glycoprotein e.herpes zoster (hz) is caused by reactivation of varicella-zoster virus (vzv) latent in the sensory ganglia and causes severe pain, often leading to postherpetic neuralgia (phn). two prophylactic vaccines against hz are currently licensed for human use, a live attenuated vaccine and a subunit vaccine containing recombinant vzv glycoprotein e (ge) as antigen. the latter has superior protective efficacy against hz and phn. during hz subunit vaccine development, we obtained chinese hamster ovary (ch ...202133897103
intratracheal inoculation of human varicella zoster virus (vzv; mav strain) vaccine successfully induced vzv igg antibodies in rhesus monkeys.the objective of this study was to investigate whether the use of live attenuated varicella zoster virus (vzv) mav vaccination can efficiently induce vzv antibody production in naive rhesus monkeys as an approach to prevent simian varicella virus (svv) reactivation in animals immunosuppressed for transplantation studies.202134022964
rare complications of chicken pox in immunocompetent children: acute respiratory distress syndrome.chickenpox is a highly contagious disease caused by varicella zoster virus. fever and papulovesicular rash are hallmarks of this disease. these manifestations are self-liming and complete recovery is seen in most cases. we report two cases of chickenpox infection where the rare and atypical manifestations of acute respiratory distress syndrome with pleural effusion were seen.202134323629
healed varicella pneumonia: a case of diffuse pulmonary microcalcifications.varicella pneumonia is a potentially fatal complication of the varicella-zoster virus (vzv), which causes the well-known chickenpox disease of childhood. identifying this type of pneumonia by characteristic features is important for radiologists and radiology residents. typical manifestations of active varicella pneumonia include diffuse pulmonary nodules, which may mimic other diseases. healed varicella pneumonia can present as diffuse, calcified pulmonary micronodules. we describe a case of he ...202134327107
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