Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| identification and characterization of a human cytomegalovirus gene coding for a membrane protein that is conserved among human herpesviruses. | a rabbit antiserum was raised against envelope material from purified human cytomegalovirus strain ad169. the serum recognized polypeptides 200, 170, 160, 75, 58, and 45 kilodaltons in size. it was used to screen a cdna library constructed from poly(a)+ rna from human cytomegalovirus-infected cells in the expression vector lambda gt11. a recombinant bacteriophage expressing cytomegalovirus-specific sequences was identified, and the corresponding gene was mapped to the hindiii r fragment. the gen ... | 1989 | 2547996 |
| phosphorylation of varicella-zoster virus glycoprotein gpi by mammalian casein kinase ii and casein kinase i. | varicella-zoster virus (vzv) glycoprotein gpi is the predominant viral glycoprotein within the plasma membranes of infected cells. this viral glycoprotein is phosphorylated on its polypeptide backbone during biosynthesis. in this report, we investigated the protein kinases which participate in the phosphorylation events. under in vivo conditions, vzv gpi was phosphorylated on its serine and threonine residues by protein kinases present within lysates of either vzv-infected or uninfected cells. b ... | 1989 | 2548005 |
| varicella in an immunocompromised patient an electron microscopic study. | we report the electron-microscopic appearances of tissues from an immunocompromised patient who died of chickenpox. we observed structures consistent with some of the reported appearances of varicella-zoster virus in cultured cells, and tubular structures that have not to our knowledge been previously described. | 1989 | 2548125 |
| [human herpesvirus 6 (hhv-6): incidence in healthy blood donors and in patients with acute infections caused by other herpes viruses]. | antibodies to hhv-6 were detected by immunofluorescence in 8.04% of 460 healthy blood donors in west austria. testing sera from patients with acute or reactivated infections with other herpesviruses, such as cytomegalovirus (cmv), epstein-barr virus (ebv), herpes simplex virus (hsv) and varicella zoster virus (vzv) we observed a remarkably higher prevalence of antibodies to hhv-6 in patients with cmv infections (75%) and also in patients with ebv infections (50%). patients with hsv and vzv infec ... | 1989 | 2548350 |
| herpes zoster infection after autologous bone marrow transplantation. | one hundred fifty-three patients who underwent autologous bone marrow transplant (abmt) were studied retrospectively to determine the frequency, outcome, and risk-factors associated with varicella-zoster infections (vzv). forty-three patients (28%) developed vzv infection after transplant. the median onset of infection was the fifth month, with 91% of cases occurring within the first year. thirty-three patients (77%) had localized herpes zoster, and ten patients (23%) had varicella. cutaneous di ... | 1989 | 2548641 |
| transcription mapping of glycoprotein i (gpi) and gpiv of varicella-zoster virus and immunological analysis of the gpi produced in cells infected with the recombinant vaccinia virus. | in order to determine the transcripts of gpi and gpiv of varicella-zoster virus (vzv), rna was isolated from human embryonic fibroblast cells infected with vzv and northern blot analysis was carried out using cloned dna probes of unique short region including gpi and gpiv genes. the analysis of rna revealed two discrete transcripts of 3.6 and 2.15 kilobases (kb) and three transcripts of 3.6, 2.9, and 1.6 kb which hybridized to dna probes covering the gpi and gpiv region, respectively. next, mrna ... | 1989 | 2549343 |
| mechanism of selective inhibition of varicella zoster virus replication by 1-beta-d-arabinofuranosyl-e-5-(2-bromovinyl)uracil. | to investigate the mechanism of action of 1-beta-d-arabinofuranosyl-(e)-5-(2-bromovinyl)uracil (bv-arau) on varicella zoster virus (vzv) replication, we examined the metabolism of the drug in vzv-infected cells using 14c-labeled bv-arau. [14c]bv-arau was taken up by the cells infected with thymidine kinase-positive (tk+)vzv, but not so much by tk- vzv-infected or mock infected cells. most of the radioactivity in tk+ vzv-infected cells that were incubated with [14c]bv-arau was recovered from thei ... | 1989 | 2549386 |
| humoral immunity and clinical reinfections following varicella vaccine in healthy children. | the duration of immunity following varicella-zoster vaccination in healthy children remains a critical issue. in a 3-year study of 140 oka/merck vaccine recipients, duration of immunity was assessed by two measures. the first was persistence of varicella-zoster antibody measured by modified fluorescent antibody to membrane antigen test. thirty-six toddler vaccinees 12 to 24 months of age had sera obtained at 6 weeks, 1 year, and 2 years. geometric mean titer +/- sd at 6 weeks was 57.7 +/- 2.9; a ... | 1989 | 2549498 |
| pathogenesis of congenital infection with three diverse viruses: varicella-zoster virus, human parvovirus, and human immunodeficiency virus. | 1989 | 2549641 | |
| dna sequence and comparative analyses of the equine herpesvirus type 1 immediate early gene. | the immediate early (ie) proteins of herpesviruses are important regulatory factors which control the expression of genes at the transcriptional level. we report the dna sequence of the immediate early gene of the alphaherpesvirus equine herpesvirus type 1 (ehv-1). this sequence is shown to be extremely rich in guanine and cytosine, resulting in a highly biased codon usage. the ie gene region possesses 38 open reading frames (orfs) greater than 300 bp in length, 11 of which have coding regions o ... | 1989 | 2549711 |
| aqueous chamber tap and serology in acute retinal necrosis. | 1989 | 2549793 | |
| prophylaxis and treatment of cytomegalovirus infections in the bone marrow transplant recipient. | almost all viral infections after bone marrow transplant (bmt) are attributable to reactivation of latent dna viruses, especially those of the herpesvirus family. the first to reactivate is herpes simplex virus, followed by cytomegalovirus (cmv) with a reported peak incidence between 60 and 90 days in most studies and varicella zoster virus about three to 18 months after bmt. epstein-barr virus rarely causes detectable illness after bmt and reactivation is only seen in the most profoundly immuno ... | 1989 | 2550409 |
| expression in recombinant vaccinia virus of the equine herpesvirus 1 gene encoding glycoprotein gp13 and protection of immunized animals. | the equine herpesvirus 1 (ehv-1) gene encoding glycoprotein 13 (gp13) was cloned into the hemagglutinin (ha) locus of vaccinia virus (copenhagen strain). expression of the gp13 gene was driven by the early/late vaccinia virus h6 promoter. metabolically radiolabeled polypeptides of approximately 47 and 44 kilodaltons and 90 kilodaltons (glycosylated form) were precipitated with both polyclonal and gp13-specific monoclonal antibodies. presentation of gp13 on the cytoplasmic membrane of cells infec ... | 1989 | 2550665 |
| varicella-zoster virus glycoprotein oligosaccharides are phosphorylated during posttranslational maturation. | varicella-zoster virus (vzv)-infected human embryonic lung fibroblasts (helf) do not release infectious virions into their growth medium. extracellular virions are pleomorphic, suggesting that they are partially degraded before their release from cells. to examine the intracellular pathway of viral maturation, [2-3h]mannose-labeled virus-encoded glycoproteins were isolated from vzv-infected helf. oligosaccharides attached to the glycoproteins were processed to complex-type units, some of which w ... | 1989 | 2550667 |
| varicella-zoster virus prevalence in japan: no significant change in a decade. | a seroepidemiologic time-comparison study was conducted to evaluate changes in igg antibody to varicella-zoster virus (vzv) and to determine vzv prevalence in japan with randomly collected serum samples from two healthy japanese populations: 1973 (n = 670) vs. 1984 (n = 677). enzyme-linked immunosorbent assay (elisa) was found to be superior to the immune adherence hemagglutination test (iaha) especially for detecting seropositivity in adults. serologic results showed essentially no significant ... | 1989 | 2550689 |
| regulation of thymidine kinase activity in mouse l cells biochemically transformed by varicella-zoster virus. | regulation of thymidine kinase (tk) activity was examined in l(o)c133 and l(h3) cells carrying varicella-zoster virus-tk gene. tk activity of l(o)c133 cells was similarly high in either medium but that of l(h3) cells was high in hat medium and low in non-hat medium. cell growth was well correlated with tk activities of l(o)c133 and l(h3) cells in medium conditions. regulation of the tk gene in l cells carrying the vzv-tk gene is discussed. | 1989 | 2550747 |
| immunological diagnosis in viral infections of the central nervous system: course of antibody titres against homo- and heterologous viruses. | in clinical cases suspected for viral encephalitis or meningoencephalitis, the estimation of virus-specific antibodies especially in liquor requires high sensitivity as well as specificity. with enzyme immunoassays the sensitivity in detecting antibodies has increased compared to e.g., complement fixation tests. this report concerns the determination of virus-specific antibodies with a commercial enzyme-linked immunosorbent assay (elisa) in paired liquor/serum samples of four patients with encep ... | 1989 | 2550755 |
| pretransplant herpes virus serology and chronic graft-versus-host disease. | the influence of pretransplant herpes virus antibodies in patients and donors in the subsequent development of chronic graft-versus-host disease (gvhd) was analysed in 150 consecutive hla identical bone marrow recipients. the cox regression bivariate analysis showed that (i) pretransplant seropositivity for cytomegalovirus (cmv) in the patients and the donors, (ii) donor seropositivity for herpes simplex virus and epstein-barr virus, (iii) high donor and patient age, (iv) a previous grade ii-iv ... | 1989 | 2551436 |
| several methods of detecting varicella-zoster virus (vzv) and measuring vzv immune status. | 1989 | 2551571 | |
| evidence for attachment of fatty acid to varicella-zoster virus glycoproteins and effect of cerulenin on the maturation of varicella-zoster virus glycoproteins. | varicella-zoster virus (vzv) contains four major glycoproteins designated gpi, gpii, gpiii, and gpiv. in the present study the presence and role of fatty acids in these glycoproteins were examined. the incorporation of fatty acid into the glycoproteins that span the membranes of vzv was studied. for this, virus-infected human embryo fibroblast cells were labeled with [3h]-palmitic acid, an extract of the cells was treated with monoclonal antibodies to vzv glycoproteins, and the precipitate was a ... | 1989 | 2551842 |
| soluble class i antigens in serum and csf of patients with varicella-zoster virus meningitis. | soluble class i antigens (shla) are secreted by lymphocytes upon activation in vitro. the intrathecal synthesis (its) of these molecules has been studied in patients with the varicella-zoster virus (vzv) meningitis. in this paper we describe a shla index ih = (csf shla/serum shla): (csf albumin/serum albumin) which is expected to increase only when shla is synthesised within the central nervous system (cns). the ih is elevated in the first week of meningitis, when antibody synthesis is still low ... | 1989 | 2552020 |
| human herpesviruses: a consideration of the latent state. | 1989 | 2552271 | |
| varicella-zoster virus infections: chronic disease in the immunocompromised host: evidence for persistent excretion of virus. | 1989 | 2552389 | |
| difficulty in determining varicella-zoster immune status in pregnant women. | 1989 | 2552391 | |
| the genomes of the human herpesviruses: contents, relationships, and evolution. | 1989 | 2552898 | |
| rapid diagnosis in varicella and herpes zoster: re-evaluation of direct smear (tzanck test) and electron microscopy including colloidal gold immuno-electron microscopy in comparison with virus isolation. | the tzanck test and electron microscopy with the technique of colloidal gold labelling in varicella-zoster virus (vzv) infections were compared with virus isolation in 54 patients with clinically suspected varicella or herpes zoster infection. the tzanck test and direct electron microscopy can determine whether or not an eruption is herpetic but cannot distinguish between herpes simplex virus (hsv) and vzv infection. however, colloidal gold immuno-electron microscopy, using monoclonal antibodies ... | 1989 | 2553095 |
| mumps, measles, and rubella vaccination and encephalitis. | 1989 | 2553173 | |
| [problems in the management of drug-resistant herpesvirus infections]. | 1989 | 2553388 | |
| [virus latency in infections with herpesviridae. herpes simplex and varicella zoster virus: pathogenesis, clinical consequences]. | once the organism has been invaded, all herpesviruses persist. this is accomplished by a change in the acute productive phase of the infection into the latent form. reactivation of the latent virus ensures renewed transmissibility of the infection. this pathogenetic principle is ensured by an extremely finely tuned virus-host interrelationship which has developed in a unique specific manner for each herpesvirus. pathogenetic fundamentals are discussed taking herpes simplex and the varicella-zost ... | 1989 | 2553561 |
| [herpes virus infections in immunosuppressed patients. herpes simplex and varicella zoster virus: prevention and therapy]. | herpes simplex virus (hsv) and varicella-zoster virus (vzv) giving rise to primary or recurrent infections still threaten immunocompromised patients. however, such prophylactic measures as passive and active immunisation against vzv infection, and antiviral chemoprophylaxis and chemotherapy of hsv- and vzv-infections have improved the prognosis of these patients considerably. | 1989 | 2553562 |
| proliferative t-cell response to glycoprotein b of the human herpes viruses: the influence of mhc and sequence of infection on the pattern of cross-reactivity. | oligopeptides of the highly conserved herpes virus glycoprotein b (gb) were expressed from dna fragments of the ebv gb (balf4) and hsv-2 gb open reading frames as fusion proteins with the lambda cii protein and beta-galactosidase (gz), respectively, in escherichia coli. after immunopurification using anti-gb or anti-gz affinity columns, the fusion proteins were used in vitro to stimulate human peripheral blood lymphocytes (pbl) or murine lymph node cells that have been primed with ebv, hsv-1, hs ... | 1989 | 2553584 |
| [disseminated herpes zoster in chronic lymphatic leukemia]. | a 73-year-old woman suffering from chronic lymphatic leukemia presented a rare variant of zoster with disseminated eruptions. ultrastructural negative staining revealed viruses of the herpes group. herpes simplex was excluded by means of fluorescence-labelled monoclonal antibodies (hsv-1/hsv-2 direct specimen identification/typing test). it is proposed that the conventional classification of zoster into a segmental and a generalized variant should be supplemented. | 1989 | 2553644 |
| persistence of varicella-zoster virus dna in blood mononuclear cells of patients with varicella or zoster. | varicella-zoster virus (vzv) dna was detectable by in-situ hybridization in blood mononuclear cells (mncs) of patients with varicella or zoster for 2-56 days after the onset of a rash. vzv dna was present in many mncs from one acute varicella patient 2 days after the onset of the rash and was rarely found in mncs during acute zoster, convalescent zoster, and convalescent varicella. the morphology of mncs containing vzv was heterogenous, although most viral-dna-containing mncs were large monocyto ... | 1989 | 2554580 |
| nucleotide sequence of the pseudorabies virus immediate early gene, encoding a strong transactivator protein. | we report the complete dna sequence of teh pseudorabies virus (prv) immediate early (ie) gene and its flanking nucleotide sequences, together comprising 5091 base pairs. an open reading frame starts with an atg codon in position 263 from the transcription-initiation site and ends with a tga codon in position 4601, thus encoding a predicted protein of 1446 amino acids (150 kd). the prv ie protein exhibits significant homology with the functionally related transactivator proteins, icp4 of herpes s ... | 1989 | 2554582 |
| [the relation of seasonal manifestations of herpes zoster and the seasonal periodicity of normal humoral immunity]. | 29 practically healthy persons and 97 herpetic ganglionitis patients were examined at different periods during 1986-1987. the seasonal changes of humoral immunity both in clinically healthy persons and in herpetic ganglionitis patients were established. the conclusion was made that clinical manifestations of herpetic ganglionitis are linked with a decrease in the level of igg ensuring natural resistance to chickenpox virus. | 1989 | 2554625 |
| molecular cloning of human uracil-dna glycosylase, a highly conserved dna repair enzyme. | uracil-dna glycosylase is the dna repair enzyme responsible for the removal of uracil from dna, and it is present in all organisms investigated. here we report on the cloning and sequencing of a cdna encoding the human uracil-dna glycosylase. the sequences of uracil-dna glycosylases from yeast, escherichia coli, herpes simplex virus type 1 and 2, and homologous genes from varicella-zoster and epstein-barr viruses are known. it is shown in this report that the predicted amino acid sequence of the ... | 1989 | 2555154 |
| cellular and humoral immunity to varicella zoster virus glycoproteins in immune and susceptible human subjects. | to further delineate the immune responses that protect against serious primary varicella zoster virus (vzv) infection and inhibit viral reactivation, antibody responses and t lymphocyte reactivity to three major vzv glycoproteins, gpi, gpii, and gpiii, were studied. individual viral glycoproteins were purified using murine monoclonal antibodies. cellular immunity was measured by lymphocyte proliferation. antibody responses were tested in enzyme-linked immunosorbent assays. individual glycoprotei ... | 1989 | 2555419 |
| identification of 21 genes of infectious laryngotracheitis virus using random sequencing of genomic dna. | dna from infectious laryngotracheitis virus (iltv) was randomly sheared and cloned into the m13 bacteriophage. clones containing iltv dna were sequenced and the predicted amino acid sequences were compared to the known sequences of other herpesviruses using computer analysis. twenty-one iltv genes were identified, 20 by comparison to varicella-zoster virus and 19 by comparison to herpes simplex virus type 1; only 12 genes, giving consistently lower homology scores, were found by comparison with ... | 1989 | 2555439 |
| clinical and biological differences between recurrent herpes simplex virus and varicella-zoster virus infections. | 1989 | 2555578 | |
| status of varicella vaccine for healthy children. | 1989 | 2555765 | |
| study of virus isolation from pharyngeal swabs in children with varicella. | we performed virus isolations from the pharyngeal swabs in 117 children with varicella who were aged from 22 days to 15 years and 70 healthy children who were aged from 3 months to 15 years, by using human embryonic lung cell cultures. viral isolates were confirmed by an indirect immunofluorescence method or by neutralization with well-characterized antibodies. five varicella-zoster virus isolates (4.3%), 23 cytomegalovirus isolates (19.7%), five herpes simplex virus isolates (4.3%), and one res ... | 1989 | 2556024 |
| transmission of chickenpox in a school setting prior to the observed exanthem. | an epidemic of chickenpox in a class is described. four children were able to transmit infection prior to the time their rash was observed by their parents. a fifth child was known to have attended school while he had localized varicelliform lesions that were present for 2 days prior to the appearance of the generalized exanthem. it cannot be ascertained whether some of the other children may have had similar lesions that were not observed at the time they attended school. the first classroom ca ... | 1989 | 2556025 |
| a method for determining the cut-off value of a varicella-zoster virus igg enzyme immunoassay for immune status. | the cut-off optical density (od) of an enzyme immunoassay (eia) for igg antibody to varicella-zoster virus (vzv) was established by application of a statistical technique to od readings on sera from known susceptible and immune populations. children aged one to three years who lacked complement fixation (cf) antibody were considered to be known susceptible subjects. adults whose sera contained antibody by the cf test were considered to be known immune subjects. the method provides a valid altern ... | 1989 | 2556421 |
| [chickenpox? but... she could have a baby any moment now!]. | 1989 | 2556646 | |
| [detection of antibodies to cytomegaloviruses, herpes simplex viruses and varicella-zoster viruses in persons positive for human immunodeficiency virus antibodies]. | forty-seven anti-hiv positive sera and 47 sera of normal individuals were analyzed to the presence of igg and igm antibodies versus cmv, hsv and vz. igg antibodies in comparison to cmv were found in 27 cases (57.44%); in comparison to hsv in 40 (85.1%) subject and to vz in 33 anti-hiv positive subjects. the mean absorbance value was higher in anti-hiv positive cases than in controls. igm antibodies in comparison to cmv were found in 3, and in comparison to hsv in 2 anti-hiv positive sera. no igm ... | 1989 | 2556804 |
| mapping of two varicella-zoster virus-encoded genes that activate the expression of viral early and late genes. | a transient assay system was used to identify varicella-zoster virus (vzv)-encoded genes whose products are able to activate the expression of an early gene promoter, the thymidine kinase (tk) promoter, and a late gene promoter, and the glycoprotein i (gpi) promoter. vero cells were cotransfected with individual cloned dna fragments spanning the entire vzv genome and with the recombinant construct p1tkcat which contained the chloramphenicol acetyl transferase (cat) gene under the control of puta ... | 1989 | 2556848 |
| differential regulation by varicella-zoster virus (vzv) and herpes simplex virus type-1 trans-activating genes. | transient expression assays were performed in vero cells in order to compare varicella-zoster virus (vzv)-encoded trans-activating proteins [defined by the products of open reading frames (orf) 4 and 62] with herpes simplex virus type-1 (hsv-1) trans-activating proteins, icp4 and icp0, with respect to activation of gene expression. we demonstrate that the product of vzv orf4 and orf62 (which are the hsv-1 analogs of icp27 and icp4, respectively) stimulate a variety of viral and cellular gene pro ... | 1989 | 2556849 |
| rapid identification and typing of herpes simplex virus by a new enzyme immunoassay with peroxidase-labeled complement c1q. | a new enzyme-linked immunoassay system (tc-elisa) was developed for the rapid, specific detection and typing of herpes simplex virus (hsv) using anti-hsv immune sera and enzyme-labeled complement component c1q (p*-c1q). the method is based on viral antigen produced in hsv-infected cells being detected by simultaneous addition of immune serum and p*-c1q (elisa-cf). with this assay, it was found that hsv was detected with anti-hsv immune serum and p*-c1q and that hsv type 1 and hsv type 2 could be ... | 1989 | 2557809 |
| explants of human oral epithelium exposed to viruses and cancer chemotherapeutics. | cultures of proliferating epithelial cells were established from explants of normal human oral epithelium from healthy young volunteers. the epithelial cells were found permissive for herpes simplex virus type 1 and type 2, coxsackie virus a-4 and a-16, adenovirus type 5, measles vaccine, rubella and influenza type a virus-. medium from deae-pretreated epithelial cultures infected with two subtypes of human immunodeficiency virus-1 showed an increasing content of virusprotein with time by antige ... | 1989 | 2558179 |
| herpes simplex virus in oral mucosal ulcers in patients with hematological malignancy. | developments of oral mucosal ulcers induced by herpes simplex virus (hsv) were studied in patients with hematologic malignancy. herpes simplex virus type-1 (hsv-1) was identified by immunological staining using virus-specific monoclonal antibodies in the epithelial cells of such ulcers from two patients with malignant lymphoma (ml), three with acute myeloblastic leukemia (aml), one with refractomy anemia with excess blasts, two with chronic myelocytic leukemia (cml), one with acute lymphoblastic ... | 1989 | 2558241 |
| association of steroid therapy with vaccine-associated rashes in children with acute lymphocytic leukaemia who received oka/merck varicella vaccine. niaid varicella vaccine collaborative study group. | oka strain varicella vaccine generally has been well tolerated by children with acute lymphocytic leukaemia (all) in remission and has induced protection against disease caused by wild-type varicella virus. at the end of 1985, four extensive vaccine-associated rashes were reported among children on maintenance chemotherapy. steroid therapy in the week before vaccination or in the week following vaccination was significantly associated with rash in a retrospective analysis (odds ratio = 3.84, p = ... | 1989 | 2558454 |
| rapid sampling of multiple enzyme reactions. | a simple method of initiating and sampling six simultaneous reactions was devised. a commercially available vial rack was fitted with a plexiglas overlaying sheet to stabilize the vials for the addition and sampling procedures. glass vials were routinely used because of their thermal conductivity advantages. samples were added and removed, and the reactions were mixed with a multichannel pipet using every other channel. the data showing six simultaneous progress curves for the rapid inactivation ... | 1989 | 2559105 |
| [a case of herpes zoster duplex with generalized eruption--study of the pathogenesis of the eruptions]. | a 77-year-old man who developed herpes zoster duplex with generalized eruptions is presented. three strains of varicella-zoster virus (vzv) were isolated from 2 skin lesions of herpes zoster and one of the generalized eruptions. for strain differentiation, these 3 strains were investigated by restriction endonuclease analysis of the viral dna. the 3 strains were identical, suggested that a single strain of vzv had been residing in a latent form in multiple spinal ganglions of this patient. we sp ... | 1989 | 2559215 |
| comparison of the sequence of the secretory glycoprotein a (ga) gene in md5 and bc-1 strains of marek's disease virus type 1. | dna fragments containing the secretory glycoprotein a (ga) gene of marek's disease virus type 1 (mdv1) were cloned from the dna libraries of very virulent md5 and virulent bc-1 strains and sequenced. two open reading frames (orf1 and orf2) were identified for both strains. the orf1 has the potential to code for a protein of 501 amino acids with a molecular weight of 56 kd that contains strong hydrophobic regions in both the amino and carboxyl termini, and nine potential n-linked glycosylation si ... | 1989 | 2559540 |
| natural killing of varicella-zoster virus (vzv)-infected fibroblasts in normal children, children with vzv infections, and children with hodgkin's disease. | we studied mononuclear cell (mnc)-mediated natural killing (nk) of varicella-zoster virus (vzv)-infected fibroblasts in normal children, children with vzv infections, and children with hodgkin's disease. nk activity was tested in 18 hr 51cr release assays. nk activity for adults was significantly higher than that for children 1-3 years old or 4-6 years old (p less than 0.05). serological status did not affect nk activity. nk activity in normal children was not increased 4-6 weeks after immunizat ... | 1989 | 2559575 |
| distribution of varicella-zoster virus strains carrying a psti-site-less mutation in japan and dna change responsible for the mutation. | we have analyzed 53 varicella-zoster virus (vzv) strains isolated in japan for the presence of a psti cleavage site in a middle portion of the long unique region of vzv genome. about 25% of the strains examined did not have this psti cleavage site, although the majority of strains retained this site. for several vzv strains lacking this psti cleavage site, we sequenced a recombinant dna-derived short segment containing the mutation. in all strains analyzed, we identified a base replacement from ... | 1989 | 2560086 |
| [zona in a 6-month-old infant. apropos of one case]. | the authors report an unusual case of zona in a 6-month-old infant whose mother was affected by varicella on the fourth month of pregnancy. the course and outcome were benign. | 1989 | 2560158 |
| congenital varicella-zoster virus infection and the failure to establish virus-specific cell-mediated immunity. | varicella-zoster virus (vzv) is one of the six human herpesviruses. the viral genome encodes five glycoproteins among its 70 open reading frames; these have been designated gpi to gpv. vzv causes the primary disease chickenpox, usually in children, after which the virus remains latent in the dorsal root ganglia. later in life, vzv reactivates and causes the disease zoster. vzv can also infect the fetus of a pregnant woman who contracts chickenpox. the fetopathy is unusual in that it more closely ... | 1989 | 2560525 |
| clinical experience of oka-strain live varicella vaccine. | 1989 | 2561119 | |
| [uveitis of viral origin]. | most well-defined viral uveitis cases are due to herpes viruses. thus, hsv and vzv may cause a chronic anterior uveitis, usually with other characteristic signs. cytomegalovirus causes a necrotic and haemorrhagic retinitis in immunosuppressed patients. acute retinal necrosis also seems to be caused by members of the herpes virus family. many cases of intraocular inflammation have been described in association with viral diseases, but this does not necessarily imply the presence of virus in the e ... | 1989 | 2562202 |
| human herpesvirus-6 and cross-reactivity with other herpesviruses. | 1989 | 2563119 | |
| varicella zoster virus and recurrent aphthous ulceration. | 1989 | 2566763 | |
| outcome in newborn babies given anti-varicella-zoster immunoglobulin after perinatal maternal infection with varicella-zoster virus. | 281 newborn babies whose mothers had chickenpox and 25 whose mothers had herpes zoster during the perinatal period were investigated. igg antibody was present at birth in all babies born more than 7 days after the onset of maternal chickenpox. when the mother's rash appeared 7-3 days before delivery progressively fewer babies were born with antibody, and no infant born less than 3 days after the onset had antibody at birth. infants were given 100 or 250 mg of anti-varicella-zoster immunoglobulin ... | 1989 | 2569560 |
| a laboratory study of age-related varicella incidence and prevalence in the czech socialist republic. | during 1972-1981, ten representative population samples totalling 2,916 individuals were tested for antibodies to varicella-zoster virus (vzv) by an indirect-haemagglutination assay (iha). statistical analysis of the results provided estimates of age-related varicella prevalence and incidence rates. it transpired that 45% of the child population had encountered varicella at preschool age and another 45% during the attendance of school. adult seropositivity rates amounted to 97.5-100%. the highes ... | 1989 | 2569816 |
| restriction fragment differences between the genomes of the oka varicella vaccine virus and american wild-type varicella-zoster virus. | the oka vaccine strains of varicella-zoster virus (vzv) have a significantly different bgii dna restriction pattern from that of american wild-type isolates of vzv. this difference consists primarily of an additional bgii site, which lies within the bamhi "d" fragment. in conjunction with a study of the efficacy of an experimental merck/oka vzv vaccine, the area of the genome from which the most marked restriction pattern alteration arises was studied more closely to determine if there are other ... | 1989 | 2573686 |
| increased migration inhibition factor production by leukocytes of patients with herpes zoster given the leukocyte ultrafiltrate. | using the direct leukocyte migration inhibition assay, the cell-mediated immune response was followed in together 47 patients suffering from herpes zoster. of these, 19 persons were treated with partially purified and concentrated lysed leukocyte ultrafiltrate. enhancement and/or earlier production of the leukocyte migration inhibition factor--in the presence of varicella-zoster virus antigen--was observed by leukocytes from patients given the ultrafiltrate on days 2-3 since the onset of the ves ... | 1989 | 2576583 |
| enhancement of plaque formation of herpes simplex virus (hsv) and varicella-zoster virus (vzv) by subinhibitory dose of acyclovir (acv). | acyclovir (9-/2-hydroxyethoxymethyl/guanine) enhanced the plaque formation of hsv and vzv at subinhibitory dose and inhibited at higher concentration but not in thymidine kinase deficient viruses. the enhancement was neutralized by thymidine. induction of viral thymidine kinase activity was not affected with acv. these results suggest that the enhancement may be mediated by viral thymidine kinase. | 1989 | 2576598 |
| characterization of the human newborn response to herpesvirus antigen. | an investigation was made into the human newborn cellular response to herpes simplex virus type 1 (hsv), cytomegalovirus (cmv), and varicella zoster virus (vzv) to understand more about the nature of the neonate's susceptibility to overwhelming infection by these viruses. newborn mononuclear cells sustained the proliferation in culture of maternal (i.e., haplotype-matched) t cell blasts with specificity for hsv, cmv, or vzv (p less than 0.05). this is evidence for intact antigen-processing capab ... | 1985 | 2580908 |
| high prevalence of serum antibody against human t cell leukemia virus type i (htlv-i) among the bismam asmat population (indonesian new guinea). | an unusually high prevalence (45%) of serum antibodies to human t cell leukemia virus type i (or to an antigenically related virus) in comparison with that observed against other viral pathogens (human immunodeficiency virus type 1, herpes simplex virus, human cytomegalovirus, varicella zoster virus, and respiratory syncytial virus) has been observed in a group of bismam asmat (papua) subjects, living in a very limited and geographically isolated area of indonesian new guinea. | 1989 | 2590558 |
| [herpes zoster in immunosuppressed patients with immuno-inflammatory disease]. | we analysed 19 episodes of herpes zoster in 16 patients, who received cytotoxic drugs or cyclosporin for immuno-inflammatory disease. reactivation of varicella-zoster virus was not associated with increased activity of the rheumatic disease nor with increased intensity of immunosuppressive therapy. six of the patients who had received the largest cumulative doses of cytotoxic drugs had fever and/or vesicles outside the primarily affected dermatome. two of these patients developed post-herpetic n ... | 1989 | 2595854 |
| herpes zoster following spinal surgery. | the onset of most cases of herpes zoster is usually sudden and unexpected. a precipitating factor is seldom obvious. depressed cellular immunity or an underlying neoplasm are found in only a small number of patients. the relationship between trauma and reactivation of the varicella-zoster virus is uncertain and most of the published cases follow trivial external injury. | 1989 | 2641675 |
| varicella-zoster virus infections after autologous bone marrow transplantation in children. | we report a retrospective analysis of children who underwent autologous bone marrow transplantation (abmt) and subsequently developed a varicella-zoster virus (vzv) infection. among 236 patients transplanted between january 1979 and december 1987, 54 (23%) aged 2 to 18.5 years (mean 7.2) developed 60 vzv infections (25%); there were 10 cases of chicken-pox in 10 patients, 43 zoster infections in 41 patients and seven disseminated zoster infections in seven patients. eighty-seven percent of vzv i ... | 1989 | 2650789 |
| acyclovir. an updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy. | acyclovir (aciclovir) is a nucleoside antiviral drug with antiviral activity in vitro against members of the herpes group of dna viruses. as an established treatment of herpes simplex infection, intravenous, oral and to a lesser extent topical formulations of acyclovir provide significant therapeutic benefit in genital herpes simplex and recurrent orofacial herpes simplex. the effect of acyclovir therapy is maximised by early initiation of treatment, especially in non-primary infection which ten ... | 1989 | 2653790 |
| topical bvdu plus low-dosage steroids in the treatment of chronic relapsing zoster keratouveitis. a pilot study. | a therapeutic trial with topical bromovinyldeoxyuridine (bvdu) plus low-dosage steroids was conducted in five patients with chronic zoster keratouveitis, who had previously received topical acyclovir (acv) and steroids. in all cases, bvdu (plus steroids) was found to be superior to acv (plus steroids). yet bvdu was not able to keep the patients from having chronic relapsing varicella-zoster keratouveitis. this can probably be explained by pathophysiological reasons, i.e., the persistence and low ... | 1989 | 2656415 |
| [new knowledge regarding herpes zoster]. | zoster is the clinical manifestation of the endogenous reactivation of the varicella-zoster virus. current observations of viral reactivation emphasize the role of cellular immunity and show an inverse correlation between the specific cellular immune response of the host and the incidence of zoster. thus, immunocompromised persons like patients with immune deficiency syndrome, lymphoproliferative cancer, or immunosuppressive therapy are at a high risk for the development of disseminated zoster, ... | 1989 | 2660444 |
| [infectious diseases in kidney transplant recipients treated with cyclosporin]. | cyclosporin (cya) is now recognized as an effective immunosuppressant to lead to a marked improvement in graft survival in organ transplant recipients. although the incidence of infection in the cya group has been decreased compared with that in the azathioprine group, infectious diseases in 400 kidney transplant recipients treated with cya were noted in our single center. treatment strategy for infectious diseases: antibiotics and/or gamma-globulin were administered to all recipients with bacte ... | 1989 | 2664294 |
| chemoprophylaxis of viral infection in immunocompromised patients. | viral infections are of increasing importance in the compromised host, particularly herpesvirus infections. both intravenous and oral acyclovir are effective in preventing reactivation of herpes simplex virus infection; oral regimens are less expensive but compliance may be problematic. varicella zoster virus reactivation can be suppressed for 6-12 months after marrow transplant using oral acyclovir, although infection may occur at the usual rate when prophylaxis is stopped. intravenous acyclovi ... | 1989 | 2680516 |
| [acyclovir and pregnancy: current aspects]. | acyclovir (acv), an antiviral nucleoside analog, is active against herpes simplex viruses (hsv1, hsv2) and varicella virus (vzv). these viruses seems to be prejudicial to the pregnant woman and to the fetus. yet, acv is not recommended for use in pregnancy. however in certain cases, this drug has been used. we review in this paper, the pharmacokinetics and transplacental passage of acv, indications, and whether the benefits of the administration of acv in pregnancy outweigh the theoretical risks ... | 1989 | 2681370 |
| [prospects and current data in antiviral chemotherapy]. | the advances achieved in our knowledge on the virus multiplication cycle and the challenge created by the advent of aids have resulted in a rational development of new antiviral agents. however, antiviral chemotherapy is hindered by several obstacles: (1) most antiviral drugs are cytotoxic, with the exception of acyclovir which owes its remarkable safety to its activation by the thymidine kinase of the herpes simplex viruses and of the varicella-zoster virus; (2) the risk of selecting resistant ... | 1989 | 2685967 |
| [effect of zovirax on the course of varicella-zoster virus (vzv) infections in children with decreased immune response]. | in 21 children with weakened immune response++ (18 patients after immunosuppression and/or after radiotherapy because of neoplastic disease, 1 patients with diagnosed hepatitis chronica persistens, 1 patient with streptococcal septicemia and one infant with protein deficiency and severe anemia) zovirax was applied in treatment of varicella virus infection. clinical observation showed a positive effect of zovirax in treatment of vzv infection which was manifested by a milder course of the infecti ... | 1989 | 2701820 |
| multiple ischemic infarcts in a child with aids, varicella zoster infection, and cerebral vasculitis. | a 4 1/2-year-old girl with acquired immunodeficiency syndrome and prolonged varicella zoster virus skin infection developed multiple ischemic strokes and radiologic and histopathologic evidence of central nervous system vasculitis. typical features of acquired immunodeficiency syndrome encephalitis were not present and there was no evidence of vasculitis outside the nervous system. central nervous system vasculitis probably resulted from varicella zoster virus infection that persisted because of ... | 1989 | 2712940 |
| disseminated ecthymatous herpes varicella-zoster virus infection in patients with acquired immunodeficiency syndrome. | herpesvirus infections are among the most common and debilitating opportunistic infections in patients with acquired immunodeficiency syndrome (aids), and they may have atypical clinical features. we describe the cases of three patients with aids in whom atypical persistent ulcerative skin lesions developed as a result of varicella-zoster virus infection. two patients had disseminated infection without a vesicular stage; one patient had underlying asteatotic eczema. all responded well to acyclov ... | 1989 | 2715411 |
| bulbar encephalitis complicating trigeminal zoster in the acquired immune deficiency syndrome. | a 30-year-old homosexual man with the acquired immune deficiency syndrome and a recent history of zoster involving the mandibular division of the right trigeminal nerve was found at autopsy to have a predominantly demyelinating lesion restricted to the ipsilateral spinal trigeminal tract and nucleus. cowdry a inclusions were readily apparent in the nuclei of numerous glia and isolated neurons, and inclusion-bearing cells were immunoreactive with an antiserum to the varicella zoster virus (vzv). ... | 1989 | 2722178 |
| [clinical signs and symptoms, and chemotherapy of varicella zoster virus infection]. | 1989 | 2724575 | |
| reinfection with varicella-zoster virus in immunocompromised patients. | a small epidemic of varicella/atypical generalized zoster among 6 immunocompromised patients and one previously healthy person is described. the 6 immunocompromised patients suffered from lymphoproliferative diseases in terminal stages treated with chemotherapy and reported varicella in their childhood. they developed a generalized maculopapular rash with hemorrhagic bullae and necroses. the infection passed from one patient to another during a 3-month period in the department. they were placed ... | 1989 | 2743800 |
| varicella pneumonia in the adult. | chickenpox pneumonia can occur in as many as half of the varicella-zoster infections in adults. although it usually exhibits a benign course, this complication can cause considerable morbidity and mortality in predisposed groups, including pregnant women and immunosuppressed patients. in these patients, the use of antiviral drugs, most notably acyclovir, has been shown to lessen the morbidity of varicella-zoster infections. early diagnosis of lung involvement from the chest x-ray or arterial blo ... | 1989 | 2748029 |
| total, anti-viral, and anti-myelin igg subclass reactivity in inflammatory diseases of the central nervous system. | total igg subclass levels, anti-viral, anti-myelin basic protein (anti-mbp), and anti-ganglioside 1 (anti-gm1) igg subclass levels were measured in 6 patients with herpes simplex virus encephalitis (hsve), 16 with borreliosis, 8 with other bacterial infections, 12 with multiple sclerosis (ms), 13 with subacute sclerosing panencephalitis (sspe), 5 with glioblastoma and 12 controls. total igg1 levels were elevated in cerebrospinal fluid (csf) from all patient groups (but not in the controls), igg2 ... | 1989 | 2760636 |
| varicella-zoster virus infections in children infected with human immunodeficiency virus. | primary varicella-zoster (vz) infection in eight children with perinatally acquired human immunodeficiency virus infection tended to be severe, prolonged, complicated by bacterial infections and in one case fatal. depletion of cd4-lymphocytes was associated with chronic and recurrent vz infection. in some patients convalescent vz antibody titers were low and did not correlate with recurrence of vz lesions. administration of acyclovir appeared to be beneficial in suppressing vz in human immunodef ... | 1989 | 2797953 |
| herpes simplex virus type 1 (hsv-1) and varicella-zoster virus (vzv) infections in saudi arabia. | the seroepidemiology of infection due to herpes simplex type 1 (hsv-1) and varicella-zoster (vzv) viruses was investigated in 224 saudi children aged from under 1 year to 15 years and 452 adults (healthy male blood donors and pregnant women) using a presently available sensitive indirect immunofluorescence technique to detect antibodies to these viruses in order to determine the age of primary infection. age-specific prevalence of igg antibodies to hsv-1 and vzv showed a progressive increase wit ... | 1989 | 2810461 |
| [isolation of viruses in the cerebrospinal fluid in a case of acute varicella meningo-encephalitis]. | the authors report a case of severe, life-threatening, meningo-encephalitis occurring in a young nonimmunodepressed adult with varicella. the demonstration of a cytopathogenetic effect of his cerebrospinal fluid and of immunoglobulins m specific to the varicella-zoster virus was in favour of an acute, directly viral-dependent encephalitis rather than an immune-mediated leucoencephalitis, as used to be commonly admitted. this is an incitement to use acyclovir in such cases, the effect of which co ... | 1987 | 2819843 |
| preventing teratogenic viral infections in hospital employees: the cases of rubella, cytomegalovirus and varicella-zoster virus. | 1987 | 2820068 | |
| cooperation between cd16(leu-11b)+ nk cells and hla-dr+ cells in natural killing of herpesvirus-infected fibroblasts. | we reported previously that natural killer (nk) cell-mediated lysis of cytomegalovirus-infected targets requires the presence of hla-dr+ nonadherent peripheral blood mononuclear cells (npbmc). in the present study we determined whether nk cell-mediated lysis of other herpesvirus-infected targets also requires hla-dr+ cells. depletion of either cluster designation (cd)16+ nk cells or hla-dr+ cells from npbmc significantly reduced their ability to lyse herpes simplex virus (hsv)- and varicella-zos ... | 1987 | 2821120 |
| seroepidemiology of varicella in children from spain. | 1987 | 2821130 | |
| [acute retinal necrosis combined with rising of varicella-zoster antibody titer in the intraocular fluid]. | 1987 | 2821158 | |
| humoral and cellular immunity to varicella-zoster virus glycoprotein gpi and to a non-glycosylated protein, p170, in the strain 2 guinea-pig. | strain 2 guinea-pigs were inoculated with infectious varicella-zoster virus (vzv) or with immunoaffinity-purified proteins of vzv. monoclonal antibodies to the vzv gpi (90,000/58,000 complex) and to a non-glycosylated protein, p170, were used to prepare the polypeptide antigens. humoral and cell-mediated immune responses to the infectious virus were compared with those elicited by the gpi and p170 proteins. both vzv igg antibody production and t lymphocyte proliferation to vzv were detected afte ... | 1987 | 2821181 |
| prenatal diagnosis of second-trimester congenital varicella syndrome by virus-specific immunoglobulin m. | 1987 | 2821214 | |
| [herpes zoster]. | 1987 | 2821453 | |
| pulmonary function following varicella-zoster pneumonia in children with leukemia. | varicella-zoster virus (vzv) is a cause of serious pneumonias in immunosuppressed patients. although there are reports of residual lung changes in adults following vzv pneumonia, no previous studies of lung function in children following this infection have been done. we studied 11 patients (median age 11 years) who had had vzv pneumonia 1 to 16 years previously. all patients had a primary diagnosis of acute lymphocytic leukemia. pneumonia was mild in most of the patients: three had only radiogr ... | 1987 | 2821472 |
| varicella in children with cancer: impact of antiviral therapy and prophylaxis. | to estimate the impact of antiviral therapy and prophylaxis on the natural course of the infection, 288 cases of varicella in children with cancer were reviewed. among 127 patients with untreated infections, the overall mortality rate was 7%. varicella-zoster virus pneumonitis developed in 28% of the untreated patients and was associated with a 25% mortality rate. pneumonitis was much more likely to develop in patients with acute leukemia than in those with other malignancies (32% v 19%). simila ... | 1987 | 2821476 |
| isomerization of the ul region of varicella-zoster virus dna. | varicella-zoster virus (vzv) dna exists principally as two isomers. despite the presence of inverted repeats bounding the long sequence region, the unique long sequence, ul, is found in one (prototype) orientation in 95-98% of vzv dna molecules and in the inverted orientation in only 2-5% of the molecules. in searching for an explanation for this disparity, we superinfected vzv-infected cells with herpes simplex virus type 1 or pseudorabies virus. neither superinfecting virus produced a measurab ... | 1987 | 2821706 |