Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| cloning and fine mapping the dna of equine herpesvirus type one defective interfering particles. | equine herpesvirus type one (ehv-1) defective interfering (di) particle dna fragments were inserted into the xbai site of the plasmid vector pacyc184. five di xbai fragments, which ranged in molecular weight from 4.5 to 6.7 mda, were selected for detailed analysis. each di dna clone was labeled with 32p-deoxynucleotides by nick translation and hybridized to genomic digests of ehv-1 standard (std) dna bound to nitrocellulose. all five clones were shown to hybridize to dna sequences derived from t ... | 1986 | 3016989 |
| equine herpesvirus genomes: heterogeneity of naturally occurring type 4 isolates and of a type 1 isolate after heterologous cell passage. | the restriction endonuclease dna fingerprints of 20 low passage, epidemiologically unrelated isolates of equine herpesvirus 4 (equine rhinopneumonitis virus) showed considerable heterogeneity in certain fragments, the positions of which were assigned to quite restricted positions on the 141 kilobase (kb) genome. we note that the heterogeneity observed in the restriction endonuclease dna fingerprints of ehv 1 (equine abortion virus) and of pseudorabies virus also tend to map to these same restric ... | 1986 | 3022687 |
| enzyme-linked immunosorbent assay for the detection of antibodies to equid herpesvirus type 1 (ehv-1). | 1986 | 3023732 | |
| [creation of an avirulent and immunogenic mutant from the rhinopneumonitis virus]. | an avirulent immunogenic virus strain mutant of the causative agent of rhinopneumonia was found to cause abortions and respiratory diseases in horses. the mutant was obtained with the use of a virulent strain that induced strongly manifested clinical symptoms of the disease, and was cultured in cell media containing 5-iodine-2-desoxiuridine as an antimetabolite, following a definite pattern. it was found that the mutant completely lost its virulence, however, it retained its immunogenicity. it l ... | 1986 | 3024389 |
| rapid method for the identification and screening of herpesviruses by dna fingerprinting combined with blot hybridization. | rapid characterization of herpesvirus isolates exemplified by equine herpesviruses is described. total dnas were isolated from virus infected small scale cell cultures. the dna fragments obtained after restriction enzyme digestion were separated on agarose gels, transferred and immobilized on filter membranes. a radioactively labelled probe derived from the purified dna of an ehv-1 reference strain was used for hybridization in order to detect the restriction fragments of different ehv-1 field i ... | 1986 | 3025240 |
| comparative efficacy of three 2'-fluoropyrimidine nucleosides and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (bw b759u) against pseudorabies and equine rhinopneumonitis virus infection in vitro and in laboratory animals. | the three 2'-fluoropyrimidine nucleosides 1-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-5-iodocytosine (fiac), 1-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-5-iodouracil (fiau), and 1-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-5-methyluracil (fmau), showed high activity in rk13 monolayers against equine rhinopneumonitis virus, (ehv-1, ic50 range 0.02-0.18 microm), aujeszky's disease virus (shv-1, pseudorabies, ic50 range 0.25-7 microm) and infectious bovine rhinotracheitis virus (1br, bhv-1, ic50 ... | 1987 | 3026244 |
| phosphorylation of nucleoside analogs by equine herpesvirus type 1 pyrimidine deoxyribonucleoside kinase. | replication of equine herpesvirus type 1 (ehv-1) was sensitive to 9-(1,3-dihydroxy-2-propoxymethyl)guanine(dhpg) but relatively resistant to e-5-(2-bromovinyl)-2'-deoxyuridine (bvdu). likewise, plaque formation by ehv-1 was inhibited by dhpg, but not by bvdu. plaque formation by a thymidine kinase-negative (tk-) mutant of ehv-1 was not inhibited by dhpg. in order to investigate biochemical mechanisms determining the differential sensitivity of ehv-1 to these drugs, the ehv-1-encoded thymidine ki ... | 1987 | 3026247 |
| segmental atresia of the transverse colon in a foal with concurrent equine herpes virus-1 infection. | segmental atresia of the transverse colon was observed at necropsy in a neonatal foal. the dorsal and ventral components of the large colon were fused, and ended blindly. the small colon was collapsed and completely closed at its cranial end. the right and left dorsal and ventral colons were fused into one blind-ended tube. histologically, eosinophilic intranuclear inclusion bodies demonstrative of equine rhinopneumonitis were present in the thymus. | 1987 | 3032513 |
| [infectious course of equine herpesvirus 1 infection in a riding stable]. | 1987 | 3032556 | |
| regulation of equine herpesvirus type 1 gene expression: characterization of immediate early, early, and late transcription. | the regulation of equine herpesvirus type 1 (ehv-1) transcription was examined in infected rabbit kidney cells using metabolic inhibitors. in order to map ehv-1 immediate early, early, and late transcripts, viral rna was 32p-labeled in vivo and hybridized to ehv-1 dna restriction fragments immobilized on nitrocellulose filters. immediate early viral rna was mapped to one region of the viral genome within the inverted repeat dna sequences (map units 0.78-0.83 and 0.95-1.0). northern blot hybridiz ... | 1987 | 3033896 |
| comparison of stationary and roller cultures for the isolation of herpesviruses affecting livestock. | the effect of rotating cultures on the isolation and cultivation of pseudorabies, infectious bovine rhinotracheitis and equine rhinopneumonitis viruses was studied. serial ten-fold dilutions of laboratory strains of these viruses and field strains of pseudorabies virus were inoculated in two each of roller and stationary tubes of appropriate cell cultures. all tubes were examined daily for the appearance of cytopathic effects. roller cultures were found to slightly enhance the speed and extent o ... | 1987 | 3035348 |
| [application of the passive hemagglutination test to the study of equine rhinopneumonitis. ii. serologic study in horses]. | 1986 | 3035677 | |
| the proteins of equid herpesvirus 1 (ehv 1) recognised by equine antisera and their ability to promote antibody-dependent cell-mediated cytotoxicity. | equine sera were used to immunoprecipitate radiolabelled virus-infected cell proteins; subsequent resolution with polyacrylamide gel electrophoresis identified the ehv-1 polypeptides vp 2, 10a, 11, 13, 14, 15, 16, 20, 21 and 23a. the humoral support of adcc by these sera was examined in vitro. cytotoxicity could be demonstrated against both subtypes irrespective of the immunising isolate. the implications of these results are discussed. | 1987 | 3035747 |
| use of lambda gt11 and monoclonal antibodies to map the genes for the six major glycoproteins of equine herpesvirus 1. | to localize the genes for the major glycoproteins of equine herpesvirus 1 (ehv-1), a library of the ehv-1 genome was constructed in the lambda gt11 expression vector. recombinant bacteriophage expressing ehv-1 glycoprotein epitopes as fusion products with beta-galactosidase were detected by immunoscreening with monoclonal antibodies specific for each of six ehv-1 glycoproteins. seventy-four recombinant lambda gt11 clones reactive with ehv-1 monoclonal antibodies were detected among 4 x 10(5) pha ... | 1987 | 3037108 |
| equine herpesvirus type 1 defective-interfering (di) particle dna structure: the central region of the inverted repeat is deleted from di dna. | the inverted repeat (irs) component of the genome of equine herpesvirus type 1 (ehv-1) is an important region of structure and function. it is a major constituent of the dna of ehv-1 defective-interfering (di) particles which have been shown to mediate the coestablishment of oncogenic transformation and persistent infection of hamster embryo cells. in addition, the irs encodes the single ehv-1 immediate early gene and the 31.5k very early protein. dna sequences encompassing ehv-1 internal irs an ... | 1987 | 3037774 |
| [equine herpesvirus 1 (ehv-1) infection in the horse: neurologic symptoms in a standard bred mare with acute fatal course. molecular characterization of the brain isolates and pathologic correlates]. | 1987 | 3038071 | |
| equine herpes myeloencephalopathy. | the neurologic form of ehv-1 infection appears to be the result of central nervous system infarction caused by vasculitis, which is initiated in endothelial cells of small blood vessels. the etiologic agent is equine herpesvirus-1, subtype 1. there is some evidence to suggest that the neurologic form of the disease actually results from reactivation of a previous infection. whether the vasculitis that causes the central nervous system injury is the direct result of the infection or an immune res ... | 1987 | 3040197 |
| antiherpesvirus activity of 9-(4-hydroxy-3-hydroxy-methylbut-1-yl)guanine (brl 39123) in cell culture. | the activity of 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine (brl 39123) against several herpesviruses was compared with that of acyclovir (acv). in plaque reduction tests with clinical isolates of herpes simplex virus type 1 (hsv-1), herpes simplex virus type 2 (hsv-2), and varicella-zoster virus, mean 50% inhibitory concentrations (ic50s) (n = number tested) for brl 39123 were 0.4 (n = 17), 1.5 (n = 13), and 3.1 (n = 5) micrograms/ml, respectively. corresponding ic50s for acv were 0.2, 0.6, an ... | 1987 | 3631945 |
| heat-inactivated frog virus 3 selectively inhibits equine herpesvirus type 1 translation in a temporal class-dependent manner. | superinfection of equine herpesvirus type 1 (ehv-1)-infected rabbit kidney cells with heat-inactivated frog virus 3 (delta fv3) differentially blocked ehv-1 protein synthesis. the extent of inhibition varied with the specific ehv-1 message, but in general late protein synthesis was inhibited more than early and immediate early translation. since fv3 has been shown to block heterologous rna and protein synthesis, it was necessary to determine whether the observed reduction in herpesvirus protein ... | 1986 | 3727402 |
| hepatitis due to equine abortion virus. comparison between the liver histology in human, canine, duckling, and equine viral hepatitis. | five livers of equine fetuses, aborted due to the action of equine abortion virus, five livers from men, two of whom died of epidemic hepatitis and three obtained by needle biopsies, 5 livers of dogs with infectious canine hepatitis and 7 livers of ducklings that had hepatitis, were studied histopathologically. the foals' livers were studied by several staining methods and the others by h. e. only. the results indicate that the lesions are quite similar in the four species with the appearance of ... | 1966 | 4225286 |
| evidence for a relationship between equine abortion (herpes) virus deoxyribonucleic acid synthesis and the s phase of the kb cell mitotic cycle. | autoradiographic analyses of deoxyribonucleic acid (dna) synthesis in randomly growing kb cell cultures infected with equine abortion virus (eav) suggested that viral dna synthesis was initiated only at times that coincided with the entry of noninfected control cells into the s phase of the cell cycle. synchronized cultures of kb cells were infected at different stages of the cell cycle, and rates of synthesis of cellular and viral dna were measured. when cells were infected at different times w ... | 1971 | 4254680 |
| kinetics of viral deoxyribonucleic acid, protein, and infectious particle production and alterations in host macromolecular syntheses in equine abortion (herpes) virus-infected cells. | infection of exponential-phase suspension cultures of mouse fibroblast cells (l-m) with equine abortion virus (eav) resulted in inhibition of cell growth and marked alterations in host metabolic processes. the synthesis of deoxyribonucleic acid (dna) and ribonucleic acid was inhibited within 4 hr after infection and was suppressed by more than 90% by the time of maximal virus replication (14 to 18 hr). the overall rate of protein synthesis, however, was similar in uninfected and virus-producing ... | 1968 | 4302745 |
| [first isolation of equine abortion virus from aborted fetus in western germany]. | 1964 | 4305858 | |
| on immunity to disease caused by equine herpesvirus 1. | 1969 | 4307796 | |
| [on antigen relationship between herpes simplex virus, herpes virus platyrrhinae (marmoset herpesvirus) and equine abortion virus]. | 1969 | 4318305 | |
| deoxyribonucleic acid synthesis in synchronized mammalian kb cells infected with herpes simplex virus. | we examined the patterns of host cell and virus deoxyribonucleic acid (dna) synthesis in synchronized cultures of kb cells infected at different stages of the cell cycle with herpes simplex virus (hsv). we found that the initiation of hsv dna synthesis, we well as the production of new infectious virus, is independent of the s, g1, and g2 phases of the mitotic cycle of the host cell. this is in contrast to data previously found with equine abortion virus. because hsv replicates independently of ... | 1971 | 4327586 |
| paralysis of horses associated with equine herpesvirus 1 infection. | 1971 | 4328999 | |
| [virological studies of the central nervous system of horse fetuses and findings in mares suffering from central nervous system disease following abortion caused by equine herpesvirus 1]. | 1972 | 4334255 | |
| protein kinase activity in equine herpesvirus. | a protein kinase which is intimately associated with equine herpesvirus (equine abortion virus) was found by using adenosine triphosphate-gamma-(32)p as a phosphate donor and virus protein as an acceptor. consistent demonstration of the activity requires prior removal of phosphohydrolase. the kinase activity requires mg(2+), is not stimulated by cyclic adenosine monophosphate, but is enhanced by added protamine or arginine-rich histone. the labeled product is resistant to ribonuclease, deoxyribo ... | 1972 | 4335515 |
| equine herpesvirus 1: biological and biophysical comparison of two viruses from different clinical entities. | 1974 | 4376548 | |
| morphological components of herpesvirus. i. intercapsomeric fibrils and the geometry of the capsid. | highly purified equine herpesvirus type 1 (ehv-1) and herpes simplex virus type 1 (hsv-1) were observed by electron microscopy in various stages of disintegration. under the conditions used, envelopes of virions usually were fragmented, and virus capsids collapsed in situ into flattened sheets of capsomeres. a matrix of intercapsomeric fibrils was observed. evidence suggesting that the capsid hexamer has threefold structural symmetry is presented. | 1974 | 4376809 |
| effect of antiviral agents in equine abortion virus-infected hamsters. | equine abortion virus, a member of the herpesvirus group, produces a lethal infection in hamsters. with this system, the protective effect of certain inhibitors of deoxyribonucleic acid viruses, inducers of interferon and exogenous interferon, was evaluated. of the various agents studied, 9-beta-d-arabinofuranosyladenine markedly suppressed mortality, and 5-iodo-2'-deoxyuridine, distamycin a, and n-ethylisatin beta-thiosemicarbazone were inactive. of the inducers tested, statolon, ultraviolet-ir ... | 1972 | 4376907 |
| [effect of air humidity on the tenacity of equine herpesvirus 1 (rhinopneumonitis virus) using different carriers]. | 1973 | 4692643 | |
| equine herpesviruses: antigenic relationships and deoxyribonucleic acid densities. | equine herpesviruses with a deoxyribonucleic acid density of 1.716 to 1.717 g/cm(3) were compared with one another by the plaque-reduction test and by the rate of development of cytopathic effect as indicated by plaque size in rabbit kidney cultures. of the 19 isolates studied, the 9 which had already been tentatively labeled equine abortion viruses were serologically similar to one another; each of them grew more quickly than did any of the other 10 isolates although the mean plaque sizes forme ... | 1973 | 4742974 |
| equine abortion (herpes) virus: evaluation of markers in a field vaccination trial. | twelve mares were vaccinated with attenuated equine abortion virus (eav) strain rac-h. two nonvaccinated mares served as controls. in at least three mares the vaccination appeared to coincide with a natural infection. this was indicated by characterization of the eav isolated from nasal secretions of six vaccinated mares, a nonvaccinated control, and also from the lung, spleen, and liver of a fetus aborted by a vaccinated mare. the relative sensitivity of the isolated eav to dithiothreitol was u ... | 1973 | 4796167 |
| comparison of four horse herpesviruses. | four equine herpesviruses (equine abortion virus, equine herpesvirus types 2 and 3, and equine cytomegalovirus) were compared. the equine abortion virus did not cross-neutralize with any of the other viruses, but the other three did show varying degrees of cross-neutralization among themselves. equine abortion virus grew more quickly in tissue cultures than did the others, and attained higher titers of infectivity in the culture fluid; it also formed plaques in a wider range of tissue culture sp ... | 1969 | 4982831 |
| equine herpesvirus type 1: the l- character in two of forty-three field isolates. brief report. | 1972 | 5063121 | |
| nucleic acid and protein synthesis in kb cells infected with equine abortion virus (equine herpesvirus type 1). | 1971 | 5099956 | |
| [research into the inactivation effect of surface-active substances on the rhinopneumonitis virus in horses (equine abortion virus)]. | 1968 | 5683868 | |
| mycoplasmal deoxyribonuclease activity in virus-infected l-cell cultures. | cell-free extracts of mycoplasma hominis and medium from 72-hr broth cultures had deoxyribonuclease activity like that of deoxyribonuclease i. mg(++) stimulated activity, and the ph optimum was between 8.0 and 9.0. double-stranded or heatdenatured deoxyribonucleic acid (dna) served as a substrate, and oligonucleotides were produced. cell-free extracts of l cells infected with m. hominis or m. hominis plus equine abortion virus (equine herpes virus, eav) had greatly increased activity over that o ... | 1969 | 5782042 |
| [electron optical demonstration of the equine abortion virus with the aid of the negative contrast procedure]. | 1964 | 5890648 | |
| [characterization of an equine abortion virus from poland and comparison with known equine rhinopneumonitis virus strains]. | 1965 | 5894190 | |
| biological and morphological aspects of the growth of equine abortion virus. | darlington, r. w. (st. jude children's research hospital, memphis, tenn.), and c. james. biological and morphological aspects of the growth of equine abortion virus. j. bacteriol. 92:250-257. 1966.-the growth of equine abortion virus (eav) was studied by bioassay and electron microscopy in l-cell monolayer and suspension cultures, and in hela and bhk 21/13 cell monolayers. results of virus assay (plaque-forming units) indicated that production of cell-associated virus (cav) began at 6 to 9 hr af ... | 1966 | 5941279 |
| the antiviral spectrum of (e)-5-(2-bromovinyl)-2'-deoxyuridine. | the antiviral activity spectrum of (e)-5-(2-bromovinyl)-2'-deoxyuridine (bvdu) is not restricted to herpes simplex virus type 1 (hsv-1) and varicella-zoster virus (vzv) but also encompasses several other herpesviruses such as suid herpesvirus type 1 (shv-1), bovid herpesvirus type 1 (bhv-1), simian varicella virus (svv), herpesvirus saimiri, herpesvirus platyrrhinae, and the baculovirus trichoplusia ni multiple nuclear polyhedrosis virus. other herpesviruses such as herpes simplex virus type 2, ... | 1984 | 6092320 |
| vaccination against equine herpesvirus 1 and equine influenza infection. | 1984 | 6093330 | |
| electron microscopy of equine respiratory viruses in organ cultures of equine fetal respiratory tract epithelium. | organ cultures of equine fetal tracheal and nasal turbinate epithelium were inoculated with equine influenza virus-a1 (eiv-a1), equine herpesvirus-1 (ehv-1), or equine rhinovirus-1 (erv-1). infected organ cultures were processed for scanning and transmission electron microscopy at various intervals and were compared with noninfected controls. organ cultures inoculated with erv-1 appeared normal with the exception of rare island-like lesions in infected nasal turbinate. virus particles were not s ... | 1984 | 6093639 |
| growth kinetics of equine respiratory tract viruses in cell and organ cultures. | growth kinetics of equine influenza virus-a1, equine herpesvirus-1, and equine rhinovirus-1 were determined in susceptible cell monolayers and in organ cultures of equine fetal tracheal and nasal turbinate epithelium. equine influenza virus-a1 was replicated in cell and organ cultures and was released more readily and for longer periods from nasal turbinate epithelium than from tracheal epithelium. equine herpesvirus-1 was also replicated in cell and organ cultures. during the first 24 hours aft ... | 1984 | 6093640 |
| functional and ultrastructural changes in neutrophils from mares and foals experimentally inoculated with a respiratory tract strain of equine herpesvirus-1. | neutrophils isolated from venous blood of adult and foal ponies inoculated with equine herpesvirus-1 were evaluated by in vitro function tests and by electron microscopy. foals had fever and severe neutropenia 24 hours after inoculation; increased neutrophil random migration under agarose and decreased antibody-dependent cell-mediated cytotoxicity were significant at 24 hours, but values had returned to preinoculation levels by 72 hours. mares had fever and leukopenia of less severity, increases ... | 1984 | 6093641 |
| pathogenicity of equine herpesvirus 1 subtype 2 for foals and adult pony mares. | three pony mares and 4 pony foals were inoculated with a subtype 2 strain of equine herpesvirus 1. foals had periods of fever 12 h and 2.5 days after inoculation and leukopenia, involving both neutrophils and lymphocytes, followed by leukocytosis. mares had transient fever and leukopenia 24 hours after inoculation that were less severe than in foals. an increase in circulating virus-neutralizing antibody was seen in 2 of 3 inoculated mares, but not in foals. attempts to isolate virus from blood ... | 1984 | 6095515 |
| [neurological disorders caused by equine herpesvirus type 1 and cauda equina neuritis in horses]. | the differences in aetiology, symptomatology, pathomorphology, diagnosis and therapy between the nervous form (paralytic form) of equine herpes virus, type 1, and neuritis caudae equinae are reviewed. the conclusion is that in most cases it is possible to differentiate between these two clinical syndromes. | 1984 | 6096984 |
| specificity of pseudorabies virus serotests. | pigs experimentally inoculated with bovine herpesvirus-1 or equine herpesvirus-1 developed mild clinical disease signs. regression of clinical disease was accompanied by development of specific virus-neutralizing antibodies. these antibodies did not react positively with pseudorabies antigens in the serum-virus neutralization test, an indirect radioimmunoassay, or a microimmunodiffusion test. | 1984 | 6098206 |
| [current virus diseases in horses. diseases in foals and respiratory tract infections]. | at the moment, horse praxis is confronted by two disease complexes which are difficult to fight against as well in prophylaxis as in therapy, but which get an increasing importance. first they concern virus infections of the foals and second primary virus-caused respiratory diseases. foals get infected during the embryonal/fetal development, in the perinatal or postnatal period. normally the infection is caused by latent infected, clinical healthy mares, or in the postnatal period by ubiquitous, ... | 1984 | 6098971 |
| molecular epidemiology and pathogenesis of some equine herpesvirus type 1 (equine abortion virus) and type 4 (equine rhinopneumonitis virus) isolates. | representative strains of ehv isolated from an aborted foetus and from a horse with rhinopneumonitis in new zealand had restriction endonuclease dna fingerprints typical of those usually associated with these syndromes elsewhere and now designated ehv1 and 4 respectively. ehv1 was isolated from the brain and spinal cord of a 4-year-old gelding that died of myeloencephalitis. a mare on the same farm, at about the same time as the gelding developed myeloencephalitis, aborted and ehv1 was isolated ... | 1984 | 6099117 |
| studies on cross-reactive antigens in the herpesviruses. | 1981 | 6162270 | |
| the prospects for antiviral chemotherapy in veterinary medicine. | 1981 | 6167058 | |
| antigenic and structural conservation of herpesvirus dna-binding proteins. | previously, we have shown a common antigen of several herpesviruses (pseudorabies virus, equine abortion virus and bovine mammillitis virus) to be antigenically related to the major dna-binding proteins of herpes simplex virus types 1 and 2. in this study we have purified the cross-reacting polypeptide from cells infected with pseudorabies virus, equine abortion virus and bovine mammillitis virus and shown the cross-reacting protein to be a major dna-binding protein for each virus. tryptic pepti ... | 1981 | 6171613 |
| chronic production of defective-interfering particles by hamster embryo cultures of herpesvirus persistently infected and oncogenically transformed cells. | highly passaged defective-interfering (di) particle preparations of equine herpesvirus type 1 (ehv-1) were found to mediate the co-establishment of persistent infection and oncogenic transformation of permissive hamster embryo cells. four cell lines, designated di-1 to di-4, were shown to possess biological properties typical of transformed cells and to induce the rapid formation of metastatic fibrosarcomas when injected into syngeneic lsh hamsters. corresponding di tumour cell lines, designated ... | 1982 | 6178795 |
| antibody to neuritogenic myelin protein p2 in equine paresis due to equine herpesvirus 1. | 1983 | 6190332 | |
| immunologic relationships between equine herpesvirus type 1 (equine abortion virus) and type 4 (equine rhinopneumonitis virus). | the specificity of selected immune responses to equine herpesvirus type 1 (ehv-1) and type 4 (ehv-4) was examined in 3 colostrum-deprived specific-pathogen-free foals. single foals were vaccinated with inactivated ehv-1, inactivated ehv-4, or control cell lysate plus adjuvant followed by successive intranasal challenge exposures with ehv-1 and ehv-4 or with ehv-4 and ehv-1. vaccination with inactivated virus preparations elicited cellular immune responses and antibody which were augmented by sub ... | 1984 | 6208822 |
| oncogenic transformation by equine herpesviruses (ehv). i. properties of hamster embryo cells transformed by ultraviolet-irradiated ehv-1. | 1980 | 6244694 | |
| alterations in virus protein synthesis and capsid production in infection with di particles of herpesvirus. | high multiplicity, undiluted passage of equine herpesvirus type 1 (ehv-1) in l-m cells resulted in the rapid production of virus particles whose genome was genetically less complex, contained more reiterated dna sequences and exhibited a greater buoyant density (rho = 1.724 g/ml) than the dna (rho = 1.716 g/ml) of standard virus. these data and the finding that these particles inhibited the replication of standard virus in interference assays confirmed that these were defective interfering (di) ... | 1980 | 6245174 |
| ehv1 and equine paresis. | 1980 | 6246670 | |
| differentiation of equine herpesviruses of type 1. | 1980 | 6250526 | |
| differentiation of subtypes within equine herpesvirus type 1. | 1980 | 6250527 | |
| clinical report of a paralytic syndrome affecting stallions, mares and foals on a thoroughbred studfarm. | an outbreak of ataxia and paralysis on a thoroughbred studfarm is reported. the cause of the disease was attributed to equid herpesvirus (ehv1) infection which stemmed from a single 10-month abortion on the studfarm. stallions, mares and foals were all affected but the most serious clinical signs occurred in the mares. there were 35 out of 39 mares, 2 out of 4 stallions and 5 out of 39 foals which exhibited signs of ataxia. nine mares became recumbent and died or were euthanased. treatment with ... | 1980 | 6250820 |
| pathological observations on an outbreak of paralysis in broodmares. | a description is given of the pathological changes present in 8 mares which died or were euthanased in the course of an outbreak of paralysis on a thoroughbred studfarm. in all cases the principal changes were in the central nervous system (cns) and consisted of a severe and widespread vaculitis in the brain, cord, sheaths of nerves, capsules of ganglia and occasionally elsewhere in the body. associated with the damage to vessel walls there was haemorrhage and exudation of plasma into the periva ... | 1980 | 6250821 |
| vaccination of pregnant ponies against equine rhinopneumonitis. | bovine herpesvirus 1247 (one dose) was given subcutaneously to five pregnant pony mares between 227 and 319 days of their gestations. there were no adverse clinical reactions, and the virus was not recovered from nasal swabs collected during a 2-week period after vaccination. four ponies foaled full-term, live, healthy foals. the foal of the fifth mare (no. 1) was found dead, but on the basis of the pathologic and virologic examinations, the virus was not considered to be the cause of the death. ... | 1980 | 6254412 |
| oncogenic transformation by by equine herpesviruses. ii. coestablishment of persistent infection and oncogenic transformation of hamster embryo cells by equine herpesvirus type 1 preparations enriched for defective interfering particles. | infection of permissive hamster embryo cells with virus preparations enriched for defective interfering (di) particles of equine herpesvirus type 1 (ehv-1) resulted in persistent infection and oncogenic transformation. six cell lines, designated di-5 to -10, exhibited biological properties (immortality, increased saturation density, growth in soft agar, etc.) inherent to transformed cells, but 2 to 18% of the total cells in these cell lines were shown to release virus as judged by electron micro ... | 1980 | 6255207 |
| response of pregnant mares to equine herpesvirus 1 (ehv1). | twenty-one pregnant mares were inoculated with ehv1. nineteen became infected as evidenced by clinical signs and/or viremia but only one mare aborted a virus-infected fetus. the viremias were leukocyte-associated and appeared to be non-productive, latent infections of these cells. infectivity, detectable by cocultivation, persisted in the circulating leukocytes for as long as 9 days without resulting in abortion. the data suggest that it is extremely difficult to evaluate the efficacy of vaccine ... | 1980 | 6257449 |
| a common code of practice for the control of contagious equine metritis and other equine reproductive diseases for the 1981 covering season in france, ireland and the united kingdom. | 1980 | 6258284 | |
| serologic responses of pregnant thoroughbred mares to vaccination with an inactivated equine herpesvirus 1 vaccine. | the immunogenic potency and safety of a chemically inactivated equine herpesvirus 1 vaccine with added adjuvant was evaluated by testing serum-neutralizing and complement-fixation antibody responses of pregnant thoroughbred mares. the vaccinated population comprised 321 pregnant mares on 7 farms; 3 in normandy, france; 1 in kildare, ireland; and 3 in central kentucky. the pattern of antibody response to vaccination was found qualitatively and quantitatively similar to that of pregnant mares prev ... | 1980 | 6259970 |
| lymphocyte responses to virus and mitogen in ponies during experimental infection with equine herpesvirus 1. | six pony foals, experimentally infected with equine herpesvirus 1 (ehv-1), were studied for their lymphocyte responses to ehv-1 and phytohemagglutinin (pha) stimulations. lymphocyte blastic transformation in the presence of ehv-1 appeared as early as 2 days after the foals were inoculated, reached a peak in 7 to 10 days, and subsequently decreased. in contrast, the lymphocyte blastic transformation in the presence of pha increased sharply, reaching a peak in 2 to 3 days, and then decreased to it ... | 1980 | 6259978 |
| complement requirement for virus neutralization by antibody and reduced serum complement levels associated with experimental equine herpesvirus 1 infection. | pony foals, negative for detectable serum-neutralizing antibody to equine herpesvirus 1 by the standard tube-culture virus neutralization test, were experimentally infected with equine herpesvirus 1. complement-requiring (cr) and non-complement-requiring (ncr) serum-neutralizing antibodies were evaluated in preinfection and postinfection sera by means of a complement-enhanced plaque reduction assay. low levels of cr antibodies were found in the preinfection sera of only group ii ponies. upon inf ... | 1981 | 6260672 |
| serological relationship between abortifacient and respiratory strains of equine herpesvirus type 1 in new zealand. | 1981 | 6262693 | |
| herpesviral diseases affecting reproduction in the horse. | 1980 | 6262988 | |
| investigations into fetal and neonatal losses in the horse. | 1980 | 6262989 | |
| systemic diseases of the newborn foal. | 1980 | 6262990 | |
| differentiation of sub-types of equine herpesvirus i by restriction endonuclease analysis. | 1981 | 6266385 | |
| the diagnosis of viral disease in equine practice. | 1981 | 6267764 | |
| differentiation of respiratory and abortigenic isolates of equine herpesvirus 1 by restriction endonucleases. | viruses classified by immunologic criteria as equine herpesvirus 1 cause respiratory disease and abortion in horses. restriction endonuclease analyses of the dna's of viruses from animals with respiratory disease and from aborted fetuses show that the patterns for respiratory viruses, while similar to each other, are entirely different from the patterns for fetal viruses. it is therefore proposed that the dna restriction endonuclease patterns of fetal and respiratory viruses analyzed in this stu ... | 1981 | 6270790 |
| structure of the genome of equine herpesvirus type 1. | 1981 | 6270904 | |
| infection of the central nervous system of horses with equine herpesvirus serotype 1. | during the last 2 years different equine herpesviruses serotype 1 strains have been isolated from cases of paretic or paralytic disease among horses in the federal republic of germany. in this paper the available information is collated and briefly reviewed. a short description of the symptoms and the possible mechanism of the pathogenesis are given. | 1981 | 6273556 |
| molecular cloning of equine herpesvirus type 1 dna: analysis of standard and defective viral genomes and viral sequences in oncogenically transformed cells. | genomic dna sequences of equine herpesvirus type 1 (ehv-1) have been cloned as bamhi and ecori restriction fragments into the plasmid pbr322 and propagated in escherichia coli. with the exception of two ecori restriction fragments that reside in the s region of the viral genome, all of the cloned fragments demonstrated the same electrophoretic mobilities, restriction cleavage sites, and blot-hybridization patterns as did the parent fragments produced by bamhi or ecori digestion of virion dna. th ... | 1981 | 6273883 |
| analysis of the genome of equine herpesvirus type 1: arrangement of cleavage sites for restriction endonucleases ecori, bglii and bamhi. | the genome of an australian isolate of equine herpesvirus type 1 (equine abortion virus) has been analysed using the restriction endonucleases ecori, bglii and bamhi, and a physical map constructed. terminal fragments were identified by exonuclease treatments, and linkage of fragments was deduced by a combination of single- and double-digest experiments and cross-blot hybridizations. the genome has a mol. wt. of 100 x 10(6) and is comprised of a short unique region bounded by repetitive sequence ... | 1981 | 6275028 |
| [comparative studies of the efficacy of paramunity inducer pind-avi, mitogen pha-p and rhinopneumonitis virus on peripheral leukocytes in the horse]. | 1981 | 6275637 | |
| an outbreak of paresis in mares and geldings associated with equid herpesvirus 1. | an outbreak of paresis occurred on a small isolated stud farm in july 1980. of the 42 horses on the stud, infection was confined to a group of nine in-foal mares and their foals and eight other horses which were either housed together at night or grazed adjacent pastures. eight mares and two geldings developed ataxia or paresis and one mare died. equid herpesvirus 1 was isolated from 17 animals and serological studies confirmed that 24 of 26 animals sampled had experienced infection. | 1981 | 6280366 |
| serologic and molecular comparisons of several equine herpesvirus type 1 strains. | the molecular and serologic relatedness of 2 recent respiratory tract isolates of equine herpesvirus type 1, designated t1 and t2, were compared with the army 183, kentucky-a hamster-adapted (kya-ha), and l-m cell-adapted (kya-lm) strains. electrophoresis in polyacrylamide gels revealed differences in virion structural proteins among 4 purified strains. seven envelope glycoproteins (molecular weight of 93,000, 65,000, 62,000, 60,000, 36,000, 20,000, and 18,000) corresponding to virion proteins 1 ... | 1981 | 6280520 |
| electron microscopic study of equine herpesvirus type 1 dna. | electron microscopic studies of equine herpesvirus dna revealed that single strands that were allowed to reanneal formed single-stranded loops with double-stranded stems only at one end of the molecule. these observations support restriction enzyme analyses which indicate that the 92-megadalton dna molecule exists as a long region of unique sequences covalently linked to a short region. the short region is comprised of an internal unique sequence, which forms the loop during reannealing of singl ... | 1982 | 6283147 |
| [cases of paresis and paralysis in a german thoroughbred stud (author's transl)]. | 1982 | 6284120 | |
| lymphocytes from ponies experimentally infected with equine herpesvirus 1: subpopulation dynamics and their response to mitogens. | six pony foals, free of detectable serum neutralization (sn) antibody against equine herpesvirus type 1 by the standard virus-neutralization (vn) test, were inoculated with equine herpesvirus type 1. the ponies showed typical clinical signs of respiratory tract disease and developed a transient leukopenia, involving lymphocytes as well as neutrophils. the leukopenia reached its lowest point on postinoculation days (pid) 3 to 5 and then returned to base-line values by pid 8 to 10. on quantitation ... | 1982 | 6285778 |
| equine influenza infections in great britain, 1979. | 1982 | 6287694 | |
| [ehv-1 myeloencephalitis in the horse]. | 1982 | 6291502 | |
| assessment of the base sequence homology between the two subtypes of equine herpesvirus 1. | the magnitude of the genetic relatedness of the two antigenic subtypes of equine herpesvirus 1 (ehv-1) was determined by dna-dna reassociation kinetics. denatured, labeled viral dna from one ehv-1 subtype was allowed to reassociate in the presence or absence of the unlabeled heterologous viral dna. the initial rate of reassociation of either labeled viral dna was increased by the presence of the heterologous viral dna to an extent indicating 10 to 20% homology between the two ehv-1 genomes. simi ... | 1982 | 6292488 |
| rhinomune (rhinopneumonitis vaccine) | 1982 | 6294955 | |
| a common code of practice for the control of contagious equine metritis and other equine reproductive diseases for the 1983 covering season in france, ireland and the united kingdom. | 1982 | 6294959 | |
| identification of the envelope surface glycoproteins of equine herpesvirus type 1. | the structural polypeptides of purified enveloped virions of the army 183 strain of equine herpesvirus type 1 (ehv-1) were examined by different analytical techniques to identify the envelope glycoproteins. glycoproteins were identified by electrophoretic analysis in polyacrylamide slab gels of virus labelled in vivo with [3h]glucosamine or labelled enzymically in vitro with either udp-[14c]galactose or sodium [3h]borohydride. fluorograms revealed eleven glycoproteins (mol. wt. 260000, 150000, 1 ... | 1982 | 6296290 |
| variation in cellular tropism between isolates of equine herpesvirus-1 in foals. | subtype-1 isolates of equine herpesvirus-1 (ehv-1) from a quadriplegic horse and from an aborted foetus were compared with each other and with a subtype-2 respiratory isolate. all 3 isolates were detected in the epithelium and macrophages of the respiratory tract. both the paresis and foetal subtype-1 isolates replicated in the epithelium of the ileum and this correlated with the recovery of virus from faeces in vivo. the paresis subtype-1 isolate also had a predelection for vascular endothelial ... | 1982 | 6297429 |
| a specific viral dna sequence is stably integrated in herpesvirus oncogenically transformed cells. | 1983 | 6297800 | |
| vaccines for ehv1. | 1983 | 6298987 | |
| molecular epizootiologic studies of equine herpesvirus-1 infections by restriction endonuclease fingerprinting of viral dna. | 1983 | 6299145 |