Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| abortion of virologically negative foetuses following experimental challenge of pregnant pony mares with equid herpesvirus 1. | from 1988 to 1991, 51 pregnant pony mares were challenged intranasally or by aerosol with an isolate of ehv-1 (ab4) originally recovered from a quadriplegic mare. this resulted in 32 abortions, occurring from 9 to 29 days after infection. in 14 of the early abortions (days 9-14), ehv-1 was not demonstrated in the foetal tissues by virus isolation or immunostaining despite no other non-viral cause for the abortion being evident. application of the polymerase chain reaction to foetal tissues from ... | 1992 | 1323457 |
| equid herpesvirus abortion--another piece in the pathogenesis puzzle. | 1992 | 1323456 | |
| a novel herpes simplex virus gene (ul49a) encodes a putative membrane protein with counterparts in other herpesviruses. | comparative analysis of dna sequences located between the coding regions of genes ul49 and ul50 of herpes simplex virus types 1 and 2 (hsv-1 and -2) has revealed a small open reading frame (orf) of 91 and 87 codons respectively with the characteristics of a genuine protein-coding region. the predicted protein products are clearly related and exhibit features of membrane-inserted proteins, with potential n-proximal signal peptides and c-proximal membrane anchor regions. counterparts are present i ... | 1992 | 1322965 |
| glycoprotein 60 of equine herpesvirus type 1 is a homologue of herpes simplex virus glycoprotein d and plays a major role in penetration of cells. | monoclonal antibodies (mabs) specific for equine herpesvirus type 1 (ehv-1) glycoprotein 60 (gp60) and gp 17/18 (f3132 and 5h6 respectively) were found to react with the same protein, which was identified as a homologue of herpes simplex virus type 1 gd. mab f3132 strongly neutralized virus infectivity and inhibited the penetration of the virus into the cell. the effects on penetration were shared with three other mabs against this protein (p68, f3116 and f3129), but no effect on virus penetrati ... | 1992 | 1321875 |
| natural killer cells in normal horses and specific-pathogen-free foals infected with equine herpesvirus. | peripheral blood mononuclear cells (pbmc) from an adult horse and from foals demonstrated natural killer (nk)-type cytotoxicity against a range of xenogeneic and allogeneic cell targets. the human tumour cell line, chang liver was consistently the most susceptible. chang liver, rabbit kidney (rk-13), equine sarcoid (es) and embryonic equine kidney (eek) cells were more susceptible when presented to horse pbmc than monolayer cultures. embryonic equine lung (eel) and murine yac-1 cells conversely, ... | 1992 | 1321530 |
| the molecular epidemiology of equine herpesvirus 1 (equine abortion virus) in australasia 1975 to 1989. | the restriction endonuclease dna fingerprints of 57 isolates of equine herpesvirus 1 (ehv1; equine abortion virus) from abortion, perinatal foal mortalities and encephalitis from 15 epidemics that occurred in australasia between 1975 and 1989 were examined using the enzymes bam hi, ecori and bgl ii. there was a remarkable degree of uniformity in the restriction patterns; mobility differences were observed in only 14 of 52 (27%) of the fragments. twelve of these 14 fragments were located within t ... | 1992 | 1320856 |
| epizootiological aspects of type 1 and type 4 equine herpesvirus infections among horse populations. | the dissemination of equine herpesvirus types 1 (ehv-1) and 4 (ehv-4) among various horse populations in japan was investigated through the isolation and typing of virus strains from horses with respiratory diseases. type specific monoclonal antibody pools were used for the typing of isolates. the 42 strains of ehv-1 and 64 strains of ehv-4 were isolated from 4593 nasal swabs and/or blood plasma samples collected from 3326 horses during a period from 1979 to 1990. all the strains of ehv-1 were i ... | 1992 | 1318750 |
| cloning and restriction endonuclease mapping of the genome of an equine herpesvirus 4 (equine rhinopneumonitis virus), strain 405/76. | purified virion dna of an australian isolate of equine herpesvirus 4(ehv 4.405/76) was digested with restriction enzymes and the dna fragments were cloned into puc19. the resulting recombinant plasmid library, representing 92% of the virus genome, was used in hybridization analyses to construct restriction maps for bamhi, ecori, and sali for the ehv4 genome. the results show that the genome of ehv 4.405/76 was approximately 145 kb and comprised a unique long (ul) region of 112 kb and a unique sh ... | 1992 | 1318713 |
| the pathogenicity of ab4p, the sequenced strain of equine herpesvirus-1, in specific pathogen-free foals. | the sequencing of the genome of equine herpesvirus-1 (ehv-1) is reported in elizabeth a. r. telford, moira s. watson, kathryn mcbride, and andrew j. davison, 1992, virology, 189, 304-316. the sequence was derived using a plaque-purified clone of ehv-1 strain ab4 (designated ab4p). to ensure that ab4p shares the pathogenic characteristics of parental ab4 (hereafter ab4), both were inoculated intranasally into foals, specifically free from ehv-1 and ehv-4. clinical signs, including rectal temperat ... | 1992 | 1318607 |
| the dna sequence of equine herpesvirus-1. | the complete dna sequence was determined of a pathogenic british isolate of equine herpesvirus-1, a respiratory virus which can cause abortion and neurological disease. the genome is 150,223 bp in size, has a base composition of 56.7% g + c, and contains 80 open reading frames likely to encode protein. since four open reading frames are duplicated in the major inverted repeat, two are probably expressed as a spliced mrna, and one may contain an internal transcriptional promoter, the genome is co ... | 1992 | 1318606 |
| identification of the equine herpesvirus type 1 glycoprotein 17/18 as a homologue of herpes simplex virus glycoprotein d. | the dna sequence of the equine herpesvirus type 1 (ehv-1) gd gene homologue has been determined for the strain ab1 and compared with previously published sequences. a portion of the gene has been located to a region of the genome which also encodes homologues of the herpes simplex virus type 1 genes for ge and gi and is known to encode an epitope of the virion protein gp17/18. analysis of the ehv-1 strain kentucky a (kya) by dna hybridization showed the presence of a gd gene homologue and establ ... | 1992 | 1316942 |
| identification and characterization of an equine herpesvirus 1 late gene encoding a potential zinc finger. | in this report, we present the dna sequence and transcriptional characterization of a gene (ir5) that maps within each of the inverted repeat (ir) segments of the equine herpesvirus type 1 (ehv-1) genome. the ir5 open reading frame (orf) is located within both ir sequences (nucleotides 9932-10,642 of the ir). dna sequence analyses of the ir5 gene region revealed an orf of 236 amino acids (24,793 da) that showed significant homology to orf64 of varicella-zoster virus and orf3 of ehv-4 both of whi ... | 1992 | 1316680 |
| open reading frames encoding a protein kinase, homolog of glycoprotein gx of pseudorabies virus, and a novel glycoprotein map within the unique short segment of equine herpesvirus type 1. | dna sequence analysis of the unique short (us) segment of the genome of equine herpesvirus type 1 kentucky a strain (ehv-1) by our laboratory and strains kentucky d and ab1 by other workers identifies a total of nine open reading frames (orf). in this report, we present the dna sequence of three of these newly identified orfs, designated eus 2, eus 3, and eus 4. the eus 2 orf is 1146 nucleotides (nt) in length and encodes a potential protein of 382 amino acids. cis-regulatory sequences upstream ... | 1992 | 1316673 |
| characterization of the glycoprotein d gene products of equine herpesvirus 1 using a prokaryotic cell expression vector. | the gene encoding equine herpesvirus 1 (equine abortion virus; ehv-1) glycoprotein d was engineered into the prokaryotic vector pex, and expressed as a beta-galactosidase fusion product, which was recognized by pooled equine sera and anti-ehv-1 rabbit sera. antibodies raised against the ehv-1 gd fusion product identified strong bands in infected cells at 66 and 68 k and at 138 k in purified virus, thus characterizing the several forms of this major envelope glycoprotein which is an important can ... | 1992 | 1316667 |
| vaccination of mares against equine herpesvirus-1. | 1992 | 1314446 | |
| reinfection and reactivation of equine herpesvirus-1 in the mouse. | balb/c mice were inoculated with equine herpesvirus-1 (ehv-1) by the intranasal (i.n.) route. mice developed respiratory signs; virus replication occurred in the respiratory tract and viraemia was detected; some mice died. recovered mice were given a second inoculation with the same strain 5 months later. following the second infection no mice died, however, virus replication was again observed in the respiratory tract and viraemia was detected once more. administration of an antiviral agent dur ... | 1992 | 1314054 |
| pathogenesis of equine herpesvirus-1 in specific pathogen-free foals: primary and secondary infections and reactivation. | six specific pathogen-free foals shown to be free of equine herpesvirus-1 and 4 (ehv-1 and -4) and lacking in maternally-derived antibodies were used to investigate the pathogenesis of ehv-1 in horses. following primary intranasal inoculation with ehv-1 all foals showed signs of a mild, self-limiting upper respiratory tract infection. a leucopenia was observed, comprising both a lymphopenia and neutropenia. virus was isolated from nasal mucus and buffy coat cells over several days during the cli ... | 1992 | 1314051 |
| [the polymerase chain reaction (pcr) for the detection of dna of equine herpesviruses 1 and 4]. | formalin-fixed and paraplast-embedded tissue samples of 42 aborted equine fetuses were examined by polymerase chain reaction for the presence of equine herpesvirus dna. the used set of primers was located in the glycoprotein 13 open reading frame and allowed the amplification of both ehv 1 und ehv 4. by cleaving pattern analysis after hinf i digestion ehv 1 could be distinguished from ehv 4. in 9 of the cases investigated ehv 1-dna was detected. this finding is in absolute context with the resul ... | 1992 | 1313672 |
| diagnosis of equid herpesviruses -1 and -4 by polymerase chain reaction. | the polymerase chain reaction (pcr) is a sensitive technique used to detect dna of viral pathogens. we have applied the technique to the detection of equid herpesviruses-1 and -4 (ehv-1 and ehv-4) dna within nasopharyngeal swab samples from horses. ninety-eight samples from suspected field cases and in-contact horses were analysed. the assays were conducted blind and later decoded and compared with virus isolation data. our results indicate that pcr is a sensitive and rapid technique for the dia ... | 1992 | 1313360 |
| equine herpesviruses: are new techniques the solution to a practical problem? | 1992 | 1313359 | |
| pathological findings in horses dying during an outbreak of the paralytic form of equid herpesvirus type 1 (ehv-1) infection. | in 1988 an outbreak of the paralytic form of equid herpesvirus type 1 (ehv-1) infection occurred on a stud farm and several animals died. this provided an opportunity to perform detailed pathological investigations to gain insights into the pathogenesis of this spontaneous disease. two paretic mares, three foals, an aborted foetus and its non-paretic dam were examined. the endotheliotropism of the virus was clearly demonstrated by the use of an indirect immunoperoxidase (ip) stain. at autopsy, e ... | 1992 | 1313358 |
| an immunoperoxidase method applied to the diagnosis of equine herpesvirus abortion, using conventional and rapid microwave techniques. | an indirect immunoperoxidase (imp) technique was applied to cryostat and paraffin sections of liver from ten aborted equine foetuses. equid herpesvirus type 1 (ehv-1) had been isolated from seven of them and ehv-4 from one: the remaining two were virologically negative and were not used as controls. in the eight virus-infected cases the immunostaining revealed foci of cells exhibiting a distinct brown cytoplasmic and inclusion body pigmentation. no specific signal was present in the non-infected ... | 1992 | 1313357 |
| characterization of enveloped tegument structures (l particles) produced by alphaherpesviruses: integrity of the tegument does not depend on the presence of capsid or envelope. | recent studies have shown that infection with herpes simplex virus type 1 (hsv-1) strain 17 generates in addition to virions a novel type of non-infectious particle. these particles, termed l particles, lack capsids and viral dna, and consist predominantly of tegument and envelope proteins. we show that l particle production is not restricted to one strain of hsv-1, and that pseudorabies virus and equine herpesvirus type 1 also release particles which are similar in composition to and morphologi ... | 1992 | 1311356 |
| rapid identification and differentiation of the vaccine strain rac h from ehv 1 field isolates using a non-radioactive dna probe. | a method for rapid differentiation between the ehv 1 live vaccine strain rac h and field isolates is described. total dna was isolated from virus-infected small scale cell cultures. dna fragments digested with restriction endonuclease bamhi were separated, transferred and immobilized on filter membranes. a digoxigenin-labeled probe derived from ehv 1 was used for hybridization. this probe hybridized specifically to sequences of the inverted terminal repeat region which in case of rac h include a ... | 1992 | 1311132 |
| characterization of the regulatory functions of the equine herpesvirus 1 immediate-early gene product. | use of the translation-inhibiting drug cycloheximide has indicated that the equine herpesvirus 1 (ehv-1) immediate-early (ie) gene, the sole ehv-1 ie gene, encodes a major viral regulatory protein since ie mrna translation is a prerequisite for all further viral gene expression (w.l. gray, r. p. baumann, a. t. robertson, g. b. caughman, d. j. o'callaghan, and j. staczek, virology 158:79-87, 1987). an ehv-1 ie gene expression vector (psvie) in combination with chimeric ehv-1 promoter-chlorampheni ... | 1992 | 1309921 |
| immune responses of specific pathogen free foals to ehv-1 infection. | four foals were raised under specific pathogen free (spf) conditions. at 3 to 4 months of age, spf foals and 1 other non-spf foal were intranasally inoculated with equine herpes virus type 1 (ehv-1). clinical signs included depression, fever, inappetence and intermittent coughing. clinical recovery was complete by seven days but high titres of virus were detected in nasal mucus for at least 10 days after inoculation. clinical illness was less severe in the non-spf foal. interferon was detected i ... | 1992 | 1280876 |
| characterization of three species of nucleocapsids of equine herpesvirus type-1 (ehv-1). | 1975 | 1167720 | |
| replication of equine herpesvirus type 1 and type 3: resistance to hydroxyurea and thymidine. | the replication of equine herpesvirus type 1 (ehv-1) and type 3 (ehv-3) was unimpeded in three different cell types-equine epithelial cells, equine fibroblasts, and mouse fibroblasts-which had been blocked in their capacity to synthesize host dna by 2.5 mm hydroxyurea (hu) or 2 mm thymidine (tdr). the rate of dna synthesis in uninfected or equine herpesvirus-infected cells in the presence of hu or tdr was measured by pulse-labeling cell samples with a labeled dna precursor at different times aft ... | 1978 | 563855 |
| the virus neutralizing activity of antibodies specific to the envelope and nucleocapsid of equine herpesvirus type 1. | antibodies specific to the envelope or nucleocapsid of the kentucky-d strain of equine herpesvirus type 1 were isolated from convalescent horse serum by immunoadsorption on cyanogen bromide-activated sepharose conjugated with equine herpesvirus type 1 envelopes or nucleocapsids, with subsequent elution by glycine buffer. in double immunodiffusion and immunolectrophoresis reactions, the eluted proteins appeared to belong to the igg fraction of horse serum. antibodies directed against the viral en ... | 1979 | 497891 |
| purification and biochemical characterization of deoxythymidine kinase of deoxythymidine kinase-deficient mouse 3t3 cells biochemically transformed by equine herpesvirus type 1. | a line of mouse 3t3 cells lacking deoxythymidine kinase (dtk-) was stably transformed to see dtk+ phenotype after exposure to ultraviolet-irradiated equine herpesvirus type 1 (ehv-1). deoxythymidine kinase (dtk) was purified from the biochemically transformed mouse cells by affinity chromatography on deoxythymidine-sepharose. the purified dtk from ehv-1-transformed 3t3 cells was identical to the dtk purified from dtk- 3t3 cells lytically infected with ehv-1 with respect to its electrophoretic mo ... | 1979 | 489123 |
| herpesvirus-induced availability of host dna to exogenous endonuclease. | deoxyribonuclease i penetrates herpesvirus-infected l cells and degrades host dna without interfering with viral multiplication. the dna of uninfected control monolayers of l cells, disrupted by scraping, is similarly attacked. in contrast, undisturbed l cells are not affected. this suggests that altered cell membrane permeability allows the nuclease to enter the cell, thereby permitting access of exogenous deoxyribonuclease to cellular dna. | 1975 | 241244 |
| an outbreak of foal perinatal mortality due to equid herpesvirus type 1: pathological observations. | twenty-nine cases of ehv1 infection occurred on a property, mainly in full term foals. some foals were stillborn, some were born alive but weak and soon died and others were healthy at birth, became ill and died within 3 days of birth. apart from voluminous, oedematous and atelectic lungs there were no gross lesions. microscopically the lungs showed oedema, pneumonitis and bronchiolitis with intranuclear inclusions and, in many of the foals that survived over 6 hours, there was also hyaline memb ... | 1979 | 232044 |
| equine herpesviruses: on the differentiation of respiratory from foetal strains of type 1. | 1979 | 231960 | |
| [central nervous system form of rhinopneumonitis virus infection]. | 1979 | 231877 | |
| newmarket outbreak: indirect contacts to be traced. | 1979 | 228468 | |
| viral respiratory disease. | 1979 | 228463 | |
| epidemiology of equine infectious respiratory disease. | 1979 | 228462 | |
| neurologic disease induced by equine herpesvirus 1. | 1979 | 227824 | |
| equine herpesvirus 1 infection in mares vaccinated with a live-virus rhinopneumonitis vaccine attenuated in cell culture. | vaccination, in july and again in either november or december 1976, of 55 pregnant standardbred mares with a live-virus rhinopneumonitis vaccine attenuated in cell culture failed to protect some mares from infection with equine herpesvirus 1. from 1976-12-08 to 1977-03-08, 33 mares foaled healthy foals, 16 mares foaled dead foals or live foals which died usually within 48 hours and six mares aborted. gross and histological examinations and virus isolation studies confirmed that equine herpesviru ... | 1979 | 226261 |
| antigenic comparisons between herpesviruses isolated from fallow deer in alberta and the viruses of infectious bovine rhinotracheitis, equine rhinopneumonitis and dn-599, a non-ibr bovine herpesvirus. | antigenic comparison studies of three herpesviruses isolated from fallow deer (dama dama) in alberta and herpesviruses from some domestic species were carried out by the alpha serum-virus neutralization test. complete cross neutralization was demonstrated among the deer herpesviruses and equine herpesvirus type 1. | 1979 | 225575 |
| immunity to equine herpesvirus 1 infection in foals during the first year of life. | a band of 23 pregnant mares on a thoroughbred breeding farm all had serum virus-neutralizing antibody titres to equine herpesvirus 1 (ehv-1). antibody was not transferred to their foals in utero. all foals received antibody from colostrum and developed antibody titres similar to their dams. the serum virus-neutralizing antibody titres were observed in 10 of these foals for 1 year. decay of passive immunity occurred at the rate of 3.25 two-fold dilutions in 100 days and reached zero at the mean t ... | 1979 | 225497 |
| equine rhinopneumonitis outbreak at newmarket. | 1979 | 224566 | |
| equine rhinopneumonitis: more deaths--warning issued. | 1979 | 224565 | |
| differentiation of field strains and a vaccine strain of equine herpesvirus 1, using plaque characteristics. | 1979 | 223480 | |
| persistent infection of a human lymphoblastoid cell line with equine herpesvirus 1. | infection of a human lymphoblastoid cell line (jijoye line derived from a burkitt lymphoma which contains epstein-barr virus) with equine herpesvirus 1, maintained and observed for 53 days, was characterized by the continuous production of infectious extracellular and intracellular virus. maximum virus production correlated with active cell multiplication. less than 15% of the cells possessed viral capsid antigen at any one time. five percent of the cells in the jijoye line possess epstein-barr ... | 1979 | 222688 |
| vaccination against diseases associated with herpesvirus infections in animals: a review. | an account is presented of the development and use of herpesvirus vaccines in domestic animals, with particular reference to those viruses causing cytolytic rather than oncogenic infections. the chief infections covered are aujeszky's disease (ad or pseudorabies), infectious bovine rhinotracheitis (ibr) and equine rhinopneumonitis (equine abortion; ehv-1). others mentioned are feline viral rhinotracheitis and malignant catarrhal fever of cattle. both live-modified and inactivated vaccines are wi ... | 1978 | 221416 |
| arabinosylthymine: in vivo effectiveness in a systemic herpesvirus infection. | 1978 | 221367 | |
| oncogenic transformation of non-permissive murine cells by viable equine herpesvirus type 1 (ehv-1) and ehv-1 dna. | primary cultures of balb/c mouse embryo fibroblasts infected with as much as 100 pfu per cell of ehv-1 do not exhibit cytopathology or synthesize detectable amounts of ehv-1 specific rna, dna, or infectious virus. addition of 1--2 microgram of non-fragmented ehv-1 dna as a co-precipitate with calcium phosphate to monolayers of such non-permissive mouse cells resulted in the appearance, after 4--6 weeks, of foci of piled-up, morphologically altered cells. cell lines established from such transfor ... | 1978 | 221355 |
| viral induced cytopathic effect & release of lysosomal enzyme. | 1978 | 220188 | |
| prevalence of antibodies to equine viruses in the netherlands. | the prevalence of antibodies to various viruses was investigated in a series of serum samples collected from horses in the netherlands between 1963 and 1966 and from 1972 onwards. neutralizing antibodies to equine rhinopneumonitis virus, equine arteritis virus and to equine rhinovirus types 1 and 2 were detected in respectively 76%, 14%, 66% and 59% of the equine serum samples tested. the observed incidence of serum samples positive to equine adenovirus in the complement fixation test was 39%. p ... | 1979 | 219560 |
| a comparative study of bovine herpesvirus 1247 and equine herpesvirus 1 in ponies. | the clinical and immunological response of ponies exposed to a bovine herpesvirus isolate and equine herpesvirus 1 were compared. each virus was inoculated into two ponies by the intranasal route. one uninoculated pony was used with each group as a contact control. the four inoculated ponies developed a mild rhinitis with an increase in rectal temperature. virus was recovered from nasal secretions collected from the four inoculated and one contact pony. all ponies developed a serum neutralizing ... | 1979 | 218710 |
| epidemiology of equine upper respiratory tract disease on standardbred racetracks. | the outbreaks of upper respiratory tract infections in horses at standardbred racetracks were investigated over a three year period. the most serious epidemics of respiratory disease occurred in the winter and spring seasons. both influenza viruses and equine herpesvirus 1 were shown to be present in the horse population. the herpesvirus was associated with respiratory disease particularly in the winter but the equine influenza viruses apparently were responsible for the major epidemics of respi ... | 1979 | 218705 |
| biological and biochemical properties of defective interfering particles of equine herpesvirus type 1. | 1979 | 218357 | |
| purification and characterization of deoxythymidine kinase (dtk) induced in dtk- 3t3 mouse cells by equine herpesvirus type 1 (ehv-1). | 1979 | 218350 | |
| proteins of equine herpesvirus type 3. i. polypeptides of the purified virion. | 1979 | 217165 | |
| case report: an outbreak of herpesvirus myeloencephalitis in vaccinated horses. | in the foaling season of 1977, five vaccinated horses in a standardbred breeding stable were affected with herpesvirus myeloencephalitis. respiratory and abortigenic forms also occurred in other individuals on the premises. equine herpesvirus type 1 was isolated from the brain of one case of myeloencephalitis and from lungs of two aborted fetuses. twelve of 16 horses demonstrated fourfold or greater increases in titres to equine herpesvirus type 1. | 1979 | 216473 |
| biological properties of equine herpesvirus type 1 dna: transfectivity and transforming capacity. | dna extracted from purified virions of equine herpesvirus type 1 (ehv-1) was examined for its transfectivity and transforming ability. the infectivity of the herpesvirus dna was demonstrated by addition of calcium phosphate-dna coprecipitates to monolayers of permissive horse cells, with resultant plaque formation. the efficiency of transfection (50 to 100 plaque-forming units/microgram of dna) was reduced by treatment of the viral dna with deoxyribonuclease or sonication but not with pronase o ... | 1978 | 215545 |
| equine rhinopneumonitis vaccine: immunogenicity and safety in foals. | 1978 | 215062 | |
| induction of deoxythymidine kinase activity in several mammalian cell lines after infection with six different strains of equine herpesvirus type 1 (ehv-1). | 1978 | 214953 | |
| effect of ribavirin on viral hepatitis in laboratory animals. | 1977 | 212975 | |
| biochemical transformation of deoxythymidine kinase-deficient mouse cells with uv-irradiated equine herpesvirus type 1. | a line of 3t3 mouse cells lacking deoxythymidine kinase (dtk-) was stably transformed to the dtk+ phenotype after exposure to uv-irradiated equine herpesvirus type 1 (ehv-1). biochemical transformants were isolated in a system selective for the dtk+ phenotype (eagle minimal essential medium containing 10(-4) m hypoxanthine, 6 x 10(-7) m aminopterin, and 2 x 10(-5) m deoxythymidine). transformation was accompanied by the acquisition of a dtk activity with immunological, electrophoretic, and bioch ... | 1978 | 212607 |
| skin hypersensitivity to equid herpesvirus type 1 in horses. | 1978 | 211756 | |
| equine abortion associated with herpesvirus. | 1978 | 210753 | |
| natural intra-uterine infection of foals with equine herpes virus type 1 in victoria. | 1978 | 210752 | |
| the protective antigens of equine herpesvirus type 1. | equine herpesvirus type 1 was cultivated in swine testis cell cultures and partially purified by differential centrifugation and centrifugation in a linear sucrose density gradient. the viral envelope was separated from the nucleocapsid by treatment with rexol 25j followed by sucrose gradient centrifugation. the envelope and nucleocapsid preparations were then electrophoresed in polyacrylamide gel after solubilization with sodium dodecyl sulphate. hamsters were immunized with various preparation ... | 1978 | 208736 |
| measurement of neutralizing antibody to equid herpesvirus 1 by single radial hemolysis. | antibody to equid herpesvirus 1, which mediates single radial hemolysis, is that responsible for neutralization. hemagglutination inhibition antibody is not necessarily involved in neutralization or hemolysis. | 1978 | 207720 |
| generalised congenital equine herpes virus infection in a neonatal foal. | 1977 | 207256 | |
| perinatal foal mortality associated with a herpesvirus. | 1977 | 207253 | |
| [electron microscopy studies on the multiplication of herpesvirus-equi-1 in brain cells of hamsters]. | 1978 | 207056 | |
| [demonstration of a clinically manifested mixed reovirus serotype iii and rhinopneumonitis virus infection in a horse]. | 1978 | 205205 | |
| equine rhinopneumonitis vaccine: immunogenicity and safety in adult horses, including pregnant mares. | 1978 | 205144 | |
| genetic relatedness of equine herpesvirus types 1 and 3. | the genetic relatedness of two types of equine herpesviruses (ehvs), 1 (ehv-1) and 3 (ehv-3), was determined by dna-dna reassociation kinetics. denatured, labeled viral dna probe was allowed to reassociate in the presence or absence of the second unlabeled viral dna. the initial rate of reassociation of either labeled viral dna was increased by the presence of the heterologous viral dna to an extent indicating only 2 to 5% homology between the two ehv genomes. moreover, labeled rna extracted fro ... | 1977 | 201775 |
| comparative analyses of the proteins and antigens of five herpesviruses. | 1977 | 200709 | |
| effect of age and pregnancy on the antibody and cell-mediated immune responses of horses to equine herpesvirus 1. | the cell-mediated immune response and antibody response of horses of varying ages and of pregnant horses to equine herpesvirus 1 antigen were examined. six to eight month old horses showed either no increase or slight increases in anti-equine herpesvirus 1 serum neutralizing antibody following vaccination and revaccination with a modified live equine herpesvirus 1 vaccine. however, these same horses showed a marked increase in the cell-mediated immune response to equine herpesvirus 1 as measured ... | 1977 | 200320 |
| cell mediated immunity in equine herpesvirus type 1 infection i. in vitro lymphocyte blastogenesis and serum neutralization antibody in normal parturient and aborting mares. | blastic transformation of peripheral blood mononuclear cells and serum neutralization antibody levels for equine herpesivurs type 1 were measured in 19 mares from three farms at the time of termination of their pregnancy by normal foaling or viral abortion. the stimulation indexes of lymphocytes obtained from the mares from two farms (farm 1 and 2) which had virus abortions, ranged from 2.1 to 10.8. but there was no significant difference in stimulation index levels between the aborting and norm ... | 1977 | 200317 |
| safety of rhinoquintm, rhinopneumonitis vaccine in foals and pregnant mares. | 1977 | 199978 | |
| equine rhinopneumonitis virus (herpesvirus type 1): attenuation in stable monkey cell line. | an isolate of virulent equine herpesvirus (ehv) type 1 was adapted to vero stable cell line by 13 serial passages at 37 c and 50 serial passages at 26 c. characteristics of the attenuated ehv-1 were found to be avirulent, but immunogenic in horses if injected intramuscularly. the attenuated virus was regularly isolated from peripheral leukocytes in inoculated horses, but was not recovered from nasal turbinate tissues. a mild leukopenia was noticed. the attenuated virus produced characteristic la ... | 1977 | 199093 |
| antiviral activity of arabinosylthymine in herpesviral replication: mechanism of action in vivo and in vitro. | 1-beta-d-arabinofuranosylthymine (ara-t), a metabolite of the sponge tethya crypta, has shown selective activity against herpes simplex virus (hsv) replication (g. a. gentry and j. f. aswell, virology 65:294-296, 1975). analysis of hsv-infected and uninfected cell lysates by cscl isopycnic centrifugation showed that ara-t blocked the incorporation of [(3)h]hypoxanthine into viral deoxyribonucleic acid and, to a large extent, into host deoxyribonucleic acid of infected (but not uninfected) cells. ... | 1977 | 197886 |
| electrophoretic separation of double-stranded rna genome segments from warrego and mitchell river viruses. | 1977 | 196574 | |
| respiratory disease in horses. | 1977 | 196170 | |
| [several years of diagnostic studies on the ehv 1 abortion in thoroughbred studs following the introduction of vaccination]. | 1977 | 195571 | |
| equine herpesvirus 1 infection of horses: studies on the experimentally induced neurologic disease. | experimental infection with equine herpesvirus 1 (rhinopneumonitis) resulted in neurologic disease in 8 of 15 inoculated horses. nonpregnant animals did not develop clinical disease, and microscopic examination of tissues revealed no changes. in all mares between 3 and 9 months of gestation, a neurologic syndrome appeared 6 to 8 days after inoculation. mares inoculated when 10 months pregnant did not develop neurologic disorders, but several aborted. the histopathologic change common to both seq ... | 1977 | 195494 |
| in vitro stimulation of foal lymphocytes with equid herpesvirus 1. | 1977 | 195321 | |
| ribonucleotide reductase activity in hydroxyurea-resistant herpesvirus replication. | 1977 | 195286 | |
| protective immunity in equine herpesvirus type i infection of hamsters. | 1977 | 194753 | |
| effects of equine rhinopneumonitis vaccination on an epizootic of race track cough (tracheopharyngitis). | 1977 | 193232 | |
| infectious causes of equine respiratory disease on ontario standardbred racetracks. | upper respiratory disease has been a serious problem in standardbred horses on racetracks in ontario, with outbreaks occurring once or twice annually in late winter and early spring seasons. to determine the causes of these epidemics, a 3-year investigation was carried out in which nasal swabs and serum samples were obtained at intervals from apparently healthy horses and from horses suffering from upper respiratory disease. the nasal swabs were used to isolate bacteria and viruses. the serum sa ... | 1977 | 192757 |
| herpesvirus transcription: altered regulation induced by fudr. | 1977 | 190769 | |
| failure to demonstrate equine rhinopneumonitis virus as a cause of abortion in mares in new zealand. | 1976 | 190568 | |
| in vitro cytotoxicity of serum and peripheral blood leukocytes for equine herpesvirus type 1-infected target cells. | the immune response in horses following experimental infection with equine herpesvirus type 1 (ehv-1) was assessed by measuring cytotoxicity for ehv-1-infected target cells. a technique was developed, using [125i]5-iodo-2'-deoxyuridine ([125i]iudr)-labeled equine fetal kidney cells infected with ehv-1 as the target cells. it was shown that peripheral blood leukocytes from a recovered horse were capable of lysing target cells, as measured by the loss of radio-active label. following the experimen ... | 1977 | 189645 |
| [combined vaccination plan against influenza, equine rhinopneumonitis and tetanus for thoroughbred horses]. | 1976 | 183944 | |
| [persistent infection of stable cell cultures by herpes virus of horses type 1 (author's transl)]. | 1976 | 183897 | |
| [infection of hela cells by herpes virus of horses type 1 in different temperature and dose of the virus (author's transl)]. | 1976 | 183896 | |
| equine herpesviruses. 6. sequential infection of horses with types 2, 3 and 1. | the immunological and virological status of 3 foals in respect of equine herpesviruses (ehv) was established and the foals were sequentially infected with ehv2, ehv3 and ehv1. following experimental infection with ehv2, no clinical signs of disease were observed in any foal. the inoculation of ehv3 into the genital tract resulted in lesions of the mucous membrane and perineal skin that were considered typical of equine coital exanthema. following intransal inoculation of ehv3 extensive ulceratio ... | 1976 | 183644 |
| letter: isolation and characterisation of equine herpes virus type 1. | 1976 | 183339 | |
| serological study of an outbreak of paresis due to equid herpesvirus 1 (ehv-1). | six cases of paresis occurred in a swedish stud with 48 mares and a stallion. complement-fixation tests revealed a recent infection with ehv-1 in most horses of the stud. serumneutralisation tests showed rapid antibody-titre increases during the course of the disease. this type of antibody response was interpreted as induced by reinfection or, possibly, recurrent infection. two diseased mares were sacrificed. no virus could be isolated from their central nervous system (cns), liver or spleen, bu ... | 1976 | 181891 |
| disseminated necrotizing myeloencephalitis: a herpes-associated neurological disease of horses. | equine viral rhinopneumonitis type i virus was isolated from spinal cord and brain of a paraparetic horse with disseminated necrotizing myeloencephalitis. necrotic arteriolitis,nonsuppurative necrotizing myeloencephalitis and gasserian ganglioneuritis were present. on record were 12 more cases of horses with similar lesions. the horses had been ataxic or paretic for up to several weeks. a field survey indicated that 14 of 24 horses with acute myelitic signs developed them after recent exposure t ... | 1976 | 180652 |
| meningoencephalomyelitis in horses associated with equine herpesvirus 1 infection. | during an outbreak of abortion caused by equine herpesvirus 1, a neurologic disease characterized clinically by dullness and ataxia occurred in several mares. equine herpesvirus 1 was isolated from brain and lung of two severely affected mares. histologically, both mares had disseminated meningoencephalomyelitis characterized by necrotizing arteritis, focal malacia in grey and white matter of brain and spinal cord, and accumulation of lymphocytes and neutrophils in paravertebral ganglia. eosinop ... | 1976 | 180650 |
| immunity to equine herpesvirus type 1 (rhinopneumonitis): in vitro lymphocyte response. | twenty-two ponies were examined for serum-neutralizing (sn) antibody to equine herpesvirus type 1 and for in vitro lymphocyte transformation in the presence of viral antigen. six ponies had undetectable levels of neutralizing antibody (titer less than 1:2) and had lymphocytes which did not respond in culture with viral antigen (stimulation index less than 2.0). four ponies which had sn antibody to equine herpesvirus type 1 did not manifest lymphocyte transformation in vitro. the 12 remaining ser ... | 1976 | 179451 |
| letter: equine virus abortion. | 1976 | 179184 |