Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| trials of an inactivated equid herpesvirus 1 vaccine: challenge with a subtype 2 virus. | serological responses following two and three doses of an inactivated equid herpesvirus 1 ( ehv -1) vaccine containing a subtype 1 strain were examined in yearling ponies. complement fixing antibody responses were significantly higher against the subtype 1 vaccine strain than against a subtype 2 virus. complement fixing antibody responses declined rapidly after the second dose of vaccine and had returned to almost pre-vaccination levels eight weeks after the second dose of vaccine. complement fi ... | 1984 | 6328729 |
| trials of an inactivated equid herpesvirus 1 vaccine: challenge with a subtype 1 virus. | vaccinated yearlings , two-year-old and in-foal pony mares with appropriate controls were exposed to aerosols of a subtype 1 virus one to two months after two or three vaccinations; all became infected. no obvious differences in the febrile responses, clinical signs and subsequent abortions were found between vaccinated and control mares. all vaccinated yearlings and two-year-old ponies developed a febrile respiratory disease but this was less severe than that suffered by the controls and the am ... | 1984 | 6328728 |
| equine cytomegalovirus: structural proteins of virions and nucleocapsids. | enveloped virions and nucleocapsids of equine cytomegalovirus (ecmv; equine herpesvirus type 2) have been purified from the supernatants and the nuclear extracts of infected rabbit kidney (rk) cells, respectively, and their structural protein compositions have been analyzed. sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis revealed that ecmv nucleocapsids were composed of nine proteins (average molecular weights = 148k, 52k, 49.5k, 46k, 43.5k, 38.5k, 27k, 20k, and 18k), which t ... | 1984 | 6324468 |
| structure of the genome of equine herpesvirus type 3. | restriction endonuclease mapping studies were performed to determine the molecular structure of the genome of equine herpesvirus type 3 (ehv-3). purified ehv-3 dna, either unlabeled or 32p-labeled, was analyzed using the restriction enzymes bamhi, bcli, bglii, ecori, and hindiii. the findings that four 0.5 m (molar) fragments were present, that two of these were terminal fragments, and that all 0.5 m fragments contained homologous dna sequences as judged by dna hybridization analyses indicated t ... | 1984 | 6322418 |
| coestablishment of persistent infection and oncogenic transformation of hamster embryo cells by equine cytomegalovirus. | semipermissive, primary hamster embryo (he) cells were morphologically transformed in vitro by infection with uv-irradiated equine cytomegalovirus (equine herpesvirus type 2; ecmv). cell lines (designated ec-1-3) were established independently from foci and were shown to exhibit growth and biological properties typically associated with transformed cells: altered morphology, loss of contact inhibition, increased saturation density, decreased generation time, immortality in culture, normal growth ... | 1984 | 6322417 |
| [the neurological form of evh1 in horses]. | 1984 | 6322380 | |
| structure and genetic complexity of the genomes of herpesvirus defective-interfering particles associated with oncogenic transformation and persistent infection. | the complexity and structural organization of defective-interfering (di) particle dna of equine herpesvirus type 1 (ehv-1) have been elucidated by using restriction enzyme and southern blot hybridization analyses. di particles were generated by serial high-multiplicity passage of ehv-1 in l-m cells, and total viral dna was extracted from virus purified from supernatants of these serial passages. ehv-1 di particle dna was quantitatively separated from standard (std) dna by several cycles of cscl ... | 1984 | 6321784 |
| a common code of practice for the control of contagious equine metritis and other equine reproductive diseases for the 1984 covering season in france, ireland and the united kingdom. | 1983 | 6318420 | |
| equine herpesvirus abortion in australia 1977 to 1982. | until 1977 no case of abortion caused by equine herpesvirus 1 (ehv1) had been recorded in australia although the virus, called equine rhinopneumonitis virus, had been known to have been present at least since 1962. outbreaks of ehv1 abortion occurred in new south wales in 1977 and in 1981. sporadic cases of ehv1 abortion had been confirmed in some parts of australia each year since 1975. it was concluded that an abortigenic subtype of ehv1 had been introduced to australia in 1977 and that the pr ... | 1983 | 6315394 |
| restriction endonuclease dna fingerprinting of respiratory, foetal and perinatal foal isolates of equine herpesvirus type 1. | dna was prepared from 43 equine herpesvirus type 1 (ehv 1) isolates, 11 of which were from horses with respiratory disease, 22 from aborted equine foetuses, and 10 from foals that died perinatally. the restriction endonuclease dna fingerprints of 10 of the 11 respiratory isolates, known with certainty to have been recovered from horses with respiratory disease, were entirely different from all but 3 of the 32 foetal or perinatal foal isolates. the exceptional respiratory isolate, ehv 1 army 183, ... | 1983 | 6314938 |
| relative activities of acyclovir and bw759 against aujeszky's disease and equine rhinopneumonitis viruses. | compound bw759 (9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine) was shown to be about 230 times more active than acyclovir (9-[2-hydroxyethoxymethyl]guanine) (acv) against equid herpesvirus type 1 infection in syrian hamsters and was more effective against aujeszky's disease in mice. the therapeutic superiority of bw759 over acv was greater than expected from quantitative inhibitory results in tissue culture with these viruses. when administered to hamsters at dose rates sufficient to preven ... | 1983 | 6314886 |
| detection of equine herpesvirus-1 antigen and the specific antibody by enzyme-linked immunosorbent assay. | enzyme-linked immunosorbent assays (elisa) were developed to detect equine herpesvirus-1 (ehv-1) antigens and specific antibodies. detection of ehv-1 antigens was done by a 4-layer elisa. in inoculated cell cultures, ehv-1 cell antigen was detected after postinoculation (pi) hour 4, reached approximately twice the value of ehv-1 viral antigen (extra-cellular virus) in pi hour 18, and peaked in pi hour 24, whereas ehv-1 viral antigen appeared after pi hour 12, increased steadily, and peaked highe ... | 1983 | 6314855 |
| the pathogenicity in mice of respiratory, abortion and paresis isolates of equine herpesvirus-1. | eleven isolates of equine herpesvirus-1 (subtype 1) all infected the brain following intracerebral inoculation of 2 d.o. mice. most isolates were from cases of paresis, abortion or respiratory disease in the u.k., but established strains were also included. they divided into two subgroups. the 5 less pathogenic isolates were characterized by being restricted predominantly to the olfactory lobes. the 6 pathogenic isolates included the three known to cause equine paresis and were detected in neuro ... | 1983 | 6310851 |
| location and orientation of homologous sequences in the genomes of five herpesviruses. | molecular hybridization experiments were carried out to investigate homologous regions in the genomes of herpes simplex virus types 1 and 2 (hsv-1 and hsv-2), equid herpesvirus 1 (ehv-1), pseudorabies virus (prv) and varicella-zoster virus (vzv). virion dna probes from ehv-1, prv and vzv hybridized to similar regions of the hsv genome, and the use of cloned dna probes allowed heterologous genomes to be oriented with respect to homologous regions. the hsv-1 and hsv-2 genomes are colinear, the ehv ... | 1983 | 6310033 |
| outbreak of equine herpesvirus abortion in the hunter valley, new south wales. | 1983 | 6309512 | |
| equine immunology 4: vaccines and antisera. | this paper attempts to relate the practicalities of vaccine development to the ideals which should be aimed for in a new vaccine. the type of immune response induced is dependent upon the nature of the antigen in the vaccine and the site and timing of its presentation to the immune system. in this respect the influence of age, maternal immunity and antigenic competition are discussed. the possible side effects associated with vaccination are defined and vaccines which are currently available for ... | 1983 | 6309511 |
| in vivo harboring of equine herpesvirus-1 in leukocyte populations and subpopulations and their quantitation from experimentally infected ponies. | 1983 | 6309042 | |
| sensitivity of equine herpesviruses 1 and 3 in vitro to a new nucleoside analogue, 9-[[2-hydroxy-1-(hydroxymethyl) ethoxy] methyl] guanine. | the following members of the herpetoviridae family were tested to determine their sensitivities to the new antiviral drug, biolf-62: equine herpesvirus types 1 and 3, human herpesvirus types 1 and 2, swine herpesvirus, bovine herpesvirus type 4, feline herpesvirus, canine herpesvirus, and herpes simiae virus. equine herpesviruses 1 and 3, human herpesviruses 1 and 2, and herpes simiae virus were all sensitive to biolf-62 at concentrations of less than 0.55 micrograms/ml. equine herpesvirus types ... | 1983 | 6307092 |
| [vaccination against the paralytic form of ehv1?]. | 1983 | 6306862 | |
| vaccines for equine herpesvirus type 1. | 1983 | 6304985 | |
| vaccines for ehv1 abortion. | 1983 | 6302971 | |
| acute infections in young foals. | 1983 | 6302008 | |
| immunogenicity of equine herpesvirus type 1 (ehv1) and equine rhinovirus type 1 (erhv1) following inactivation by betapropiolactone (bpl) and ultraviolet (uv) light. | some kinetic data on the inactivation of equine herpesvirus type 1 (ehv1) and equine rhinovirus type 1 (erhv1) by betapropiolactone (bpl) and ultraviolet (uv) irradiation are reported. 0.25% bpl at 37 degrees c for 1 h reduced the titre of ehv1 by greater than 10(3 . 4) and of erhv1 by greater than 10(4 . 1) tcid50/ml. uv irradiation (334 microw/cm2) produced similar reductions in titre after 2 min. these data were used as a basis for inactivating ehv1 and erhv1 by the combined action of bpl and ... | 1982 | 6301141 |
| genetic relatedness of the genomes of equine herpesvirus types 1, 2, and 3. | genomic dnas of equine herpesvirus type 1 (ehv-1), ehv-2 (equine cytomegalovirus), and ehv-3 were examined by reassociation kinetic and thermal denaturation analyses to determine the extent and degree of homology among the three viral dnas. results of reassociation analyses indicated a limited homology among the three ehv genomes. homologous dna sequences equivalent to 1.8 to 3.7 megadaltons between ehv-1 and equine cytomegalovirus, 7.6 to 8.2 megadaltons between ehv-1 and ehv-3, and 1.3 to 1.9 ... | 1983 | 6300438 |
| alterations in the equine herpesvirus 1 genome after in vitro and in vivo virus passage. | the effect of in vitro and in vivo serial virus passage on the genetic stability of equine herpesvirus 1 (ehv-1) was investigated by restriction endonuclease analysis of the viral dna. dnas of ehv-1 isolates at different passage levels in cultured cells or in syrian hamsters were compared by electrophoresis of the dna cleavage fragments produced by restriction endonuclease digestion. no changes were observed in the restriction profile of the dnas of ehv-1 strains after 100 sequential passages in ... | 1983 | 6299965 |
| application of a chemically inactivated, adjuvanted vaccine to control abortigenic infection of mares by equine herpesvirus i. | a chemically inactivated, adjuvanted vaccine prepared from a virulent strain of equine herpesvirus i (ehv-i) was used to immunize pregnant thoroughbred broodmares during a five-year field test designed to determine its safety and efficacy. each mare in the vaccinated groups received 3 intramuscular injections of vaccine beginning immediately prior to and during the last half of pregnancy. vaccine was injected at approximately 60-day intervals. the accumulated incidence of ehv-i abortions among v ... | 1982 | 6299858 |
| infectious center assay of intracellular virus and infective virus titer for equine mononuclear cells infected in vivo and in vitro with equine herpesviruses. | a novel, simple method of infectious center assay was developed to detect and quantitate the intracellular existence of equine herpesvirus 1 and equine herpesvirus 2 in peripheral blood mononuclear cells infected in vivo and in vitro with the viruses by cocultivation of these cells with a permissive equine cell culture. the infectious center titers were correlated with the infectious virus titers. in vivo equine herpesvirus 1-infected mononuclear cells obtained from ponies experimentally infecte ... | 1983 | 6299486 |
| molecular epizootiologic studies of equine herpesvirus-1 infections by restriction endonuclease fingerprinting of viral dna. | 1983 | 6299145 | |
| vaccines for ehv1. | 1983 | 6298987 | |
| a specific viral dna sequence is stably integrated in herpesvirus oncogenically transformed cells. | 1983 | 6297800 | |
| variation in cellular tropism between isolates of equine herpesvirus-1 in foals. | subtype-1 isolates of equine herpesvirus-1 (ehv-1) from a quadriplegic horse and from an aborted foetus were compared with each other and with a subtype-2 respiratory isolate. all 3 isolates were detected in the epithelium and macrophages of the respiratory tract. both the paresis and foetal subtype-1 isolates replicated in the epithelium of the ileum and this correlated with the recovery of virus from faeces in vivo. the paresis subtype-1 isolate also had a predelection for vascular endothelial ... | 1982 | 6297429 |
| identification of the envelope surface glycoproteins of equine herpesvirus type 1. | the structural polypeptides of purified enveloped virions of the army 183 strain of equine herpesvirus type 1 (ehv-1) were examined by different analytical techniques to identify the envelope glycoproteins. glycoproteins were identified by electrophoretic analysis in polyacrylamide slab gels of virus labelled in vivo with [3h]glucosamine or labelled enzymically in vitro with either udp-[14c]galactose or sodium [3h]borohydride. fluorograms revealed eleven glycoproteins (mol. wt. 260000, 150000, 1 ... | 1982 | 6296290 |
| a common code of practice for the control of contagious equine metritis and other equine reproductive diseases for the 1983 covering season in france, ireland and the united kingdom. | 1982 | 6294959 | |
| rhinomune (rhinopneumonitis vaccine) | 1982 | 6294955 | |
| assessment of the base sequence homology between the two subtypes of equine herpesvirus 1. | the magnitude of the genetic relatedness of the two antigenic subtypes of equine herpesvirus 1 (ehv-1) was determined by dna-dna reassociation kinetics. denatured, labeled viral dna from one ehv-1 subtype was allowed to reassociate in the presence or absence of the unlabeled heterologous viral dna. the initial rate of reassociation of either labeled viral dna was increased by the presence of the heterologous viral dna to an extent indicating 10 to 20% homology between the two ehv-1 genomes. simi ... | 1982 | 6292488 |
| [ehv-1 myeloencephalitis in the horse]. | 1982 | 6291502 | |
| equine influenza infections in great britain, 1979. | 1982 | 6287694 | |
| lymphocytes from ponies experimentally infected with equine herpesvirus 1: subpopulation dynamics and their response to mitogens. | six pony foals, free of detectable serum neutralization (sn) antibody against equine herpesvirus type 1 by the standard virus-neutralization (vn) test, were inoculated with equine herpesvirus type 1. the ponies showed typical clinical signs of respiratory tract disease and developed a transient leukopenia, involving lymphocytes as well as neutrophils. the leukopenia reached its lowest point on postinoculation days (pid) 3 to 5 and then returned to base-line values by pid 8 to 10. on quantitation ... | 1982 | 6285778 |
| [cases of paresis and paralysis in a german thoroughbred stud (author's transl)]. | 1982 | 6284120 | |
| electron microscopic study of equine herpesvirus type 1 dna. | electron microscopic studies of equine herpesvirus dna revealed that single strands that were allowed to reanneal formed single-stranded loops with double-stranded stems only at one end of the molecule. these observations support restriction enzyme analyses which indicate that the 92-megadalton dna molecule exists as a long region of unique sequences covalently linked to a short region. the short region is comprised of an internal unique sequence, which forms the loop during reannealing of singl ... | 1982 | 6283147 |
| serologic and molecular comparisons of several equine herpesvirus type 1 strains. | the molecular and serologic relatedness of 2 recent respiratory tract isolates of equine herpesvirus type 1, designated t1 and t2, were compared with the army 183, kentucky-a hamster-adapted (kya-ha), and l-m cell-adapted (kya-lm) strains. electrophoresis in polyacrylamide gels revealed differences in virion structural proteins among 4 purified strains. seven envelope glycoproteins (molecular weight of 93,000, 65,000, 62,000, 60,000, 36,000, 20,000, and 18,000) corresponding to virion proteins 1 ... | 1981 | 6280520 |
| an outbreak of paresis in mares and geldings associated with equid herpesvirus 1. | an outbreak of paresis occurred on a small isolated stud farm in july 1980. of the 42 horses on the stud, infection was confined to a group of nine in-foal mares and their foals and eight other horses which were either housed together at night or grazed adjacent pastures. eight mares and two geldings developed ataxia or paresis and one mare died. equid herpesvirus 1 was isolated from 17 animals and serological studies confirmed that 24 of 26 animals sampled had experienced infection. | 1981 | 6280366 |
| [comparative studies of the efficacy of paramunity inducer pind-avi, mitogen pha-p and rhinopneumonitis virus on peripheral leukocytes in the horse]. | 1981 | 6275637 | |
| analysis of the genome of equine herpesvirus type 1: arrangement of cleavage sites for restriction endonucleases ecori, bglii and bamhi. | the genome of an australian isolate of equine herpesvirus type 1 (equine abortion virus) has been analysed using the restriction endonucleases ecori, bglii and bamhi, and a physical map constructed. terminal fragments were identified by exonuclease treatments, and linkage of fragments was deduced by a combination of single- and double-digest experiments and cross-blot hybridizations. the genome has a mol. wt. of 100 x 10(6) and is comprised of a short unique region bounded by repetitive sequence ... | 1981 | 6275028 |
| molecular cloning of equine herpesvirus type 1 dna: analysis of standard and defective viral genomes and viral sequences in oncogenically transformed cells. | genomic dna sequences of equine herpesvirus type 1 (ehv-1) have been cloned as bamhi and ecori restriction fragments into the plasmid pbr322 and propagated in escherichia coli. with the exception of two ecori restriction fragments that reside in the s region of the viral genome, all of the cloned fragments demonstrated the same electrophoretic mobilities, restriction cleavage sites, and blot-hybridization patterns as did the parent fragments produced by bamhi or ecori digestion of virion dna. th ... | 1981 | 6273883 |
| infection of the central nervous system of horses with equine herpesvirus serotype 1. | during the last 2 years different equine herpesviruses serotype 1 strains have been isolated from cases of paretic or paralytic disease among horses in the federal republic of germany. in this paper the available information is collated and briefly reviewed. a short description of the symptoms and the possible mechanism of the pathogenesis are given. | 1981 | 6273556 |
| structure of the genome of equine herpesvirus type 1. | 1981 | 6270904 | |
| differentiation of respiratory and abortigenic isolates of equine herpesvirus 1 by restriction endonucleases. | viruses classified by immunologic criteria as equine herpesvirus 1 cause respiratory disease and abortion in horses. restriction endonuclease analyses of the dna's of viruses from animals with respiratory disease and from aborted fetuses show that the patterns for respiratory viruses, while similar to each other, are entirely different from the patterns for fetal viruses. it is therefore proposed that the dna restriction endonuclease patterns of fetal and respiratory viruses analyzed in this stu ... | 1981 | 6270790 |
| the diagnosis of viral disease in equine practice. | 1981 | 6267764 | |
| differentiation of sub-types of equine herpesvirus i by restriction endonuclease analysis. | 1981 | 6266385 | |
| systemic diseases of the newborn foal. | 1980 | 6262990 | |
| investigations into fetal and neonatal losses in the horse. | 1980 | 6262989 | |
| herpesviral diseases affecting reproduction in the horse. | 1980 | 6262988 | |
| serological relationship between abortifacient and respiratory strains of equine herpesvirus type 1 in new zealand. | 1981 | 6262693 | |
| complement requirement for virus neutralization by antibody and reduced serum complement levels associated with experimental equine herpesvirus 1 infection. | pony foals, negative for detectable serum-neutralizing antibody to equine herpesvirus 1 by the standard tube-culture virus neutralization test, were experimentally infected with equine herpesvirus 1. complement-requiring (cr) and non-complement-requiring (ncr) serum-neutralizing antibodies were evaluated in preinfection and postinfection sera by means of a complement-enhanced plaque reduction assay. low levels of cr antibodies were found in the preinfection sera of only group ii ponies. upon inf ... | 1981 | 6260672 |
| lymphocyte responses to virus and mitogen in ponies during experimental infection with equine herpesvirus 1. | six pony foals, experimentally infected with equine herpesvirus 1 (ehv-1), were studied for their lymphocyte responses to ehv-1 and phytohemagglutinin (pha) stimulations. lymphocyte blastic transformation in the presence of ehv-1 appeared as early as 2 days after the foals were inoculated, reached a peak in 7 to 10 days, and subsequently decreased. in contrast, the lymphocyte blastic transformation in the presence of pha increased sharply, reaching a peak in 2 to 3 days, and then decreased to it ... | 1980 | 6259978 |
| serologic responses of pregnant thoroughbred mares to vaccination with an inactivated equine herpesvirus 1 vaccine. | the immunogenic potency and safety of a chemically inactivated equine herpesvirus 1 vaccine with added adjuvant was evaluated by testing serum-neutralizing and complement-fixation antibody responses of pregnant thoroughbred mares. the vaccinated population comprised 321 pregnant mares on 7 farms; 3 in normandy, france; 1 in kildare, ireland; and 3 in central kentucky. the pattern of antibody response to vaccination was found qualitatively and quantitatively similar to that of pregnant mares prev ... | 1980 | 6259970 |
| a common code of practice for the control of contagious equine metritis and other equine reproductive diseases for the 1981 covering season in france, ireland and the united kingdom. | 1980 | 6258284 | |
| response of pregnant mares to equine herpesvirus 1 (ehv1). | twenty-one pregnant mares were inoculated with ehv1. nineteen became infected as evidenced by clinical signs and/or viremia but only one mare aborted a virus-infected fetus. the viremias were leukocyte-associated and appeared to be non-productive, latent infections of these cells. infectivity, detectable by cocultivation, persisted in the circulating leukocytes for as long as 9 days without resulting in abortion. the data suggest that it is extremely difficult to evaluate the efficacy of vaccine ... | 1980 | 6257449 |
| oncogenic transformation by by equine herpesviruses. ii. coestablishment of persistent infection and oncogenic transformation of hamster embryo cells by equine herpesvirus type 1 preparations enriched for defective interfering particles. | infection of permissive hamster embryo cells with virus preparations enriched for defective interfering (di) particles of equine herpesvirus type 1 (ehv-1) resulted in persistent infection and oncogenic transformation. six cell lines, designated di-5 to -10, exhibited biological properties (immortality, increased saturation density, growth in soft agar, etc.) inherent to transformed cells, but 2 to 18% of the total cells in these cell lines were shown to release virus as judged by electron micro ... | 1980 | 6255207 |
| vaccination of pregnant ponies against equine rhinopneumonitis. | bovine herpesvirus 1247 (one dose) was given subcutaneously to five pregnant pony mares between 227 and 319 days of their gestations. there were no adverse clinical reactions, and the virus was not recovered from nasal swabs collected during a 2-week period after vaccination. four ponies foaled full-term, live, healthy foals. the foal of the fifth mare (no. 1) was found dead, but on the basis of the pathologic and virologic examinations, the virus was not considered to be the cause of the death. ... | 1980 | 6254412 |
| pathological observations on an outbreak of paralysis in broodmares. | a description is given of the pathological changes present in 8 mares which died or were euthanased in the course of an outbreak of paralysis on a thoroughbred studfarm. in all cases the principal changes were in the central nervous system (cns) and consisted of a severe and widespread vaculitis in the brain, cord, sheaths of nerves, capsules of ganglia and occasionally elsewhere in the body. associated with the damage to vessel walls there was haemorrhage and exudation of plasma into the periva ... | 1980 | 6250821 |
| clinical report of a paralytic syndrome affecting stallions, mares and foals on a thoroughbred studfarm. | an outbreak of ataxia and paralysis on a thoroughbred studfarm is reported. the cause of the disease was attributed to equid herpesvirus (ehv1) infection which stemmed from a single 10-month abortion on the studfarm. stallions, mares and foals were all affected but the most serious clinical signs occurred in the mares. there were 35 out of 39 mares, 2 out of 4 stallions and 5 out of 39 foals which exhibited signs of ataxia. nine mares became recumbent and died or were euthanased. treatment with ... | 1980 | 6250820 |
| differentiation of subtypes within equine herpesvirus type 1. | 1980 | 6250527 | |
| differentiation of equine herpesviruses of type 1. | 1980 | 6250526 | |
| ehv1 and equine paresis. | 1980 | 6246670 | |
| alterations in virus protein synthesis and capsid production in infection with di particles of herpesvirus. | high multiplicity, undiluted passage of equine herpesvirus type 1 (ehv-1) in l-m cells resulted in the rapid production of virus particles whose genome was genetically less complex, contained more reiterated dna sequences and exhibited a greater buoyant density (rho = 1.724 g/ml) than the dna (rho = 1.716 g/ml) of standard virus. these data and the finding that these particles inhibited the replication of standard virus in interference assays confirmed that these were defective interfering (di) ... | 1980 | 6245174 |
| oncogenic transformation by equine herpesviruses (ehv). i. properties of hamster embryo cells transformed by ultraviolet-irradiated ehv-1. | 1980 | 6244694 | |
| immunologic relationships between equine herpesvirus type 1 (equine abortion virus) and type 4 (equine rhinopneumonitis virus). | the specificity of selected immune responses to equine herpesvirus type 1 (ehv-1) and type 4 (ehv-4) was examined in 3 colostrum-deprived specific-pathogen-free foals. single foals were vaccinated with inactivated ehv-1, inactivated ehv-4, or control cell lysate plus adjuvant followed by successive intranasal challenge exposures with ehv-1 and ehv-4 or with ehv-4 and ehv-1. vaccination with inactivated virus preparations elicited cellular immune responses and antibody which were augmented by sub ... | 1984 | 6208822 |
| antibody to neuritogenic myelin protein p2 in equine paresis due to equine herpesvirus 1. | 1983 | 6190332 | |
| chronic production of defective-interfering particles by hamster embryo cultures of herpesvirus persistently infected and oncogenically transformed cells. | highly passaged defective-interfering (di) particle preparations of equine herpesvirus type 1 (ehv-1) were found to mediate the co-establishment of persistent infection and oncogenic transformation of permissive hamster embryo cells. four cell lines, designated di-1 to di-4, were shown to possess biological properties typical of transformed cells and to induce the rapid formation of metastatic fibrosarcomas when injected into syngeneic lsh hamsters. corresponding di tumour cell lines, designated ... | 1982 | 6178795 |
| antigenic and structural conservation of herpesvirus dna-binding proteins. | previously, we have shown a common antigen of several herpesviruses (pseudorabies virus, equine abortion virus and bovine mammillitis virus) to be antigenically related to the major dna-binding proteins of herpes simplex virus types 1 and 2. in this study we have purified the cross-reacting polypeptide from cells infected with pseudorabies virus, equine abortion virus and bovine mammillitis virus and shown the cross-reacting protein to be a major dna-binding protein for each virus. tryptic pepti ... | 1981 | 6171613 |
| the prospects for antiviral chemotherapy in veterinary medicine. | 1981 | 6167058 | |
| studies on cross-reactive antigens in the herpesviruses. | 1981 | 6162270 | |
| molecular epidemiology and pathogenesis of some equine herpesvirus type 1 (equine abortion virus) and type 4 (equine rhinopneumonitis virus) isolates. | representative strains of ehv isolated from an aborted foetus and from a horse with rhinopneumonitis in new zealand had restriction endonuclease dna fingerprints typical of those usually associated with these syndromes elsewhere and now designated ehv1 and 4 respectively. ehv1 was isolated from the brain and spinal cord of a 4-year-old gelding that died of myeloencephalitis. a mare on the same farm, at about the same time as the gelding developed myeloencephalitis, aborted and ehv1 was isolated ... | 1984 | 6099117 |
| [current virus diseases in horses. diseases in foals and respiratory tract infections]. | at the moment, horse praxis is confronted by two disease complexes which are difficult to fight against as well in prophylaxis as in therapy, but which get an increasing importance. first they concern virus infections of the foals and second primary virus-caused respiratory diseases. foals get infected during the embryonal/fetal development, in the perinatal or postnatal period. normally the infection is caused by latent infected, clinical healthy mares, or in the postnatal period by ubiquitous, ... | 1984 | 6098971 |
| specificity of pseudorabies virus serotests. | pigs experimentally inoculated with bovine herpesvirus-1 or equine herpesvirus-1 developed mild clinical disease signs. regression of clinical disease was accompanied by development of specific virus-neutralizing antibodies. these antibodies did not react positively with pseudorabies antigens in the serum-virus neutralization test, an indirect radioimmunoassay, or a microimmunodiffusion test. | 1984 | 6098206 |
| [neurological disorders caused by equine herpesvirus type 1 and cauda equina neuritis in horses]. | the differences in aetiology, symptomatology, pathomorphology, diagnosis and therapy between the nervous form (paralytic form) of equine herpes virus, type 1, and neuritis caudae equinae are reviewed. the conclusion is that in most cases it is possible to differentiate between these two clinical syndromes. | 1984 | 6096984 |
| pathogenicity of equine herpesvirus 1 subtype 2 for foals and adult pony mares. | three pony mares and 4 pony foals were inoculated with a subtype 2 strain of equine herpesvirus 1. foals had periods of fever 12 h and 2.5 days after inoculation and leukopenia, involving both neutrophils and lymphocytes, followed by leukocytosis. mares had transient fever and leukopenia 24 hours after inoculation that were less severe than in foals. an increase in circulating virus-neutralizing antibody was seen in 2 of 3 inoculated mares, but not in foals. attempts to isolate virus from blood ... | 1984 | 6095515 |
| functional and ultrastructural changes in neutrophils from mares and foals experimentally inoculated with a respiratory tract strain of equine herpesvirus-1. | neutrophils isolated from venous blood of adult and foal ponies inoculated with equine herpesvirus-1 were evaluated by in vitro function tests and by electron microscopy. foals had fever and severe neutropenia 24 hours after inoculation; increased neutrophil random migration under agarose and decreased antibody-dependent cell-mediated cytotoxicity were significant at 24 hours, but values had returned to preinoculation levels by 72 hours. mares had fever and leukopenia of less severity, increases ... | 1984 | 6093641 |
| growth kinetics of equine respiratory tract viruses in cell and organ cultures. | growth kinetics of equine influenza virus-a1, equine herpesvirus-1, and equine rhinovirus-1 were determined in susceptible cell monolayers and in organ cultures of equine fetal tracheal and nasal turbinate epithelium. equine influenza virus-a1 was replicated in cell and organ cultures and was released more readily and for longer periods from nasal turbinate epithelium than from tracheal epithelium. equine herpesvirus-1 was also replicated in cell and organ cultures. during the first 24 hours aft ... | 1984 | 6093640 |
| electron microscopy of equine respiratory viruses in organ cultures of equine fetal respiratory tract epithelium. | organ cultures of equine fetal tracheal and nasal turbinate epithelium were inoculated with equine influenza virus-a1 (eiv-a1), equine herpesvirus-1 (ehv-1), or equine rhinovirus-1 (erv-1). infected organ cultures were processed for scanning and transmission electron microscopy at various intervals and were compared with noninfected controls. organ cultures inoculated with erv-1 appeared normal with the exception of rare island-like lesions in infected nasal turbinate. virus particles were not s ... | 1984 | 6093639 |
| vaccination against equine herpesvirus 1 and equine influenza infection. | 1984 | 6093330 | |
| the antiviral spectrum of (e)-5-(2-bromovinyl)-2'-deoxyuridine. | the antiviral activity spectrum of (e)-5-(2-bromovinyl)-2'-deoxyuridine (bvdu) is not restricted to herpes simplex virus type 1 (hsv-1) and varicella-zoster virus (vzv) but also encompasses several other herpesviruses such as suid herpesvirus type 1 (shv-1), bovid herpesvirus type 1 (bhv-1), simian varicella virus (svv), herpesvirus saimiri, herpesvirus platyrrhinae, and the baculovirus trichoplusia ni multiple nuclear polyhedrosis virus. other herpesviruses such as herpes simplex virus type 2, ... | 1984 | 6092320 |
| biological and morphological aspects of the growth of equine abortion virus. | darlington, r. w. (st. jude children's research hospital, memphis, tenn.), and c. james. biological and morphological aspects of the growth of equine abortion virus. j. bacteriol. 92:250-257. 1966.-the growth of equine abortion virus (eav) was studied by bioassay and electron microscopy in l-cell monolayer and suspension cultures, and in hela and bhk 21/13 cell monolayers. results of virus assay (plaque-forming units) indicated that production of cell-associated virus (cav) began at 6 to 9 hr af ... | 1966 | 5941279 |
| [characterization of an equine abortion virus from poland and comparison with known equine rhinopneumonitis virus strains]. | 1965 | 5894190 | |
| [electron optical demonstration of the equine abortion virus with the aid of the negative contrast procedure]. | 1964 | 5890648 | |
| mycoplasmal deoxyribonuclease activity in virus-infected l-cell cultures. | cell-free extracts of mycoplasma hominis and medium from 72-hr broth cultures had deoxyribonuclease activity like that of deoxyribonuclease i. mg(++) stimulated activity, and the ph optimum was between 8.0 and 9.0. double-stranded or heatdenatured deoxyribonucleic acid (dna) served as a substrate, and oligonucleotides were produced. cell-free extracts of l cells infected with m. hominis or m. hominis plus equine abortion virus (equine herpes virus, eav) had greatly increased activity over that o ... | 1969 | 5782042 |
| [research into the inactivation effect of surface-active substances on the rhinopneumonitis virus in horses (equine abortion virus)]. | 1968 | 5683868 | |
| nucleic acid and protein synthesis in kb cells infected with equine abortion virus (equine herpesvirus type 1). | 1971 | 5099956 | |
| equine herpesvirus type 1: the l- character in two of forty-three field isolates. brief report. | 1972 | 5063121 | |
| comparison of four horse herpesviruses. | four equine herpesviruses (equine abortion virus, equine herpesvirus types 2 and 3, and equine cytomegalovirus) were compared. the equine abortion virus did not cross-neutralize with any of the other viruses, but the other three did show varying degrees of cross-neutralization among themselves. equine abortion virus grew more quickly in tissue cultures than did the others, and attained higher titers of infectivity in the culture fluid; it also formed plaques in a wider range of tissue culture sp ... | 1969 | 4982831 |
| equine abortion (herpes) virus: evaluation of markers in a field vaccination trial. | twelve mares were vaccinated with attenuated equine abortion virus (eav) strain rac-h. two nonvaccinated mares served as controls. in at least three mares the vaccination appeared to coincide with a natural infection. this was indicated by characterization of the eav isolated from nasal secretions of six vaccinated mares, a nonvaccinated control, and also from the lung, spleen, and liver of a fetus aborted by a vaccinated mare. the relative sensitivity of the isolated eav to dithiothreitol was u ... | 1973 | 4796167 |
| equine herpesviruses: antigenic relationships and deoxyribonucleic acid densities. | equine herpesviruses with a deoxyribonucleic acid density of 1.716 to 1.717 g/cm(3) were compared with one another by the plaque-reduction test and by the rate of development of cytopathic effect as indicated by plaque size in rabbit kidney cultures. of the 19 isolates studied, the 9 which had already been tentatively labeled equine abortion viruses were serologically similar to one another; each of them grew more quickly than did any of the other 10 isolates although the mean plaque sizes forme ... | 1973 | 4742974 |
| [effect of air humidity on the tenacity of equine herpesvirus 1 (rhinopneumonitis virus) using different carriers]. | 1973 | 4692643 | |
| effect of antiviral agents in equine abortion virus-infected hamsters. | equine abortion virus, a member of the herpesvirus group, produces a lethal infection in hamsters. with this system, the protective effect of certain inhibitors of deoxyribonucleic acid viruses, inducers of interferon and exogenous interferon, was evaluated. of the various agents studied, 9-beta-d-arabinofuranosyladenine markedly suppressed mortality, and 5-iodo-2'-deoxyuridine, distamycin a, and n-ethylisatin beta-thiosemicarbazone were inactive. of the inducers tested, statolon, ultraviolet-ir ... | 1972 | 4376907 |
| morphological components of herpesvirus. i. intercapsomeric fibrils and the geometry of the capsid. | highly purified equine herpesvirus type 1 (ehv-1) and herpes simplex virus type 1 (hsv-1) were observed by electron microscopy in various stages of disintegration. under the conditions used, envelopes of virions usually were fragmented, and virus capsids collapsed in situ into flattened sheets of capsomeres. a matrix of intercapsomeric fibrils was observed. evidence suggesting that the capsid hexamer has threefold structural symmetry is presented. | 1974 | 4376809 |
| equine herpesvirus 1: biological and biophysical comparison of two viruses from different clinical entities. | 1974 | 4376548 | |
| protein kinase activity in equine herpesvirus. | a protein kinase which is intimately associated with equine herpesvirus (equine abortion virus) was found by using adenosine triphosphate-gamma-(32)p as a phosphate donor and virus protein as an acceptor. consistent demonstration of the activity requires prior removal of phosphohydrolase. the kinase activity requires mg(2+), is not stimulated by cyclic adenosine monophosphate, but is enhanced by added protamine or arginine-rich histone. the labeled product is resistant to ribonuclease, deoxyribo ... | 1972 | 4335515 |
| [virological studies of the central nervous system of horse fetuses and findings in mares suffering from central nervous system disease following abortion caused by equine herpesvirus 1]. | 1972 | 4334255 |