Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| cidofovir is effective against caprine herpesvirus 1 infection in goats. | caprine herpesvirus 1 (cphv-1) is a virus able to cause genital infection leading to vulvovaginitis or balanoposthitis in adult goats. cphv-1 shares several biological similarities with herpes simplex type 2 (hsv-2) infection in man, such as genital tropism, type and site of typical lesions and it might provide an animal model for studies on antiviral drugs for hsv-2 infection in man. in this view the efficacy of cidofovir (cdv) drug was tested in six goats intravaginally infected with ba.1 stra ... | 2007 | 17161474 |
| factors that affect in vitro measurement of the susceptibility of herpes simplex virus to nucleoside analogues. | to identify factors that contribute to variability of hsv antiviral susceptibility breakpoints. | 2007 | 17169605 |
| appropriate use of polymerase chain reaction for detection of herpes simplex virus 2 in cerebrospinal fluid of patients at an inner-city hospital. | polymerase chain reaction (pcr) tests that detect herpes simplex virus (hsv) dna in cerebrospinal fluid (csf) are increasingly used to diagnose central nervous system (cns) infections caused by hsv. to determine proper utilization of this test at an inner-city hospital, we performed a case-control study of adult patients, with hsv detected in csf by pcr. retrospective review of characteristics of adult patients hospitalized between 1997 and 2000 with csf positive for hsv was done and compared to ... | 2007 | 17175126 |
| human herpesvirus 8 and human herpesvirus 2 infections in prison population. | incarcerated persons have high rates of infectious diseases. few data on the prevalence of sexually transmitted diseases in prisoners are available. this multi-center cross-sectional study enrolled 973 inmates from eight italian prisons. demographic and behavioral data were collected using an anonymous standardized questionnaire and antibodies to hiv, hcv, hbv, hsv-2, and hhv-8 were detected in a blood sample obtained from each person at the time of the enrollment in the study. two hundred and t ... | 2007 | 17177300 |
| increased prevalence of varicella zoster virus dna in cerebrospinal fluid from patients with multiple sclerosis. | in order to investigate the possible involvement of viruses in multiple sclerosis (ms), the study evaluated the presence of viral genomic sequences in cerebrospinal fluid (csf), as markers of viral replication within the central nervous system (cns). a total of 85 csf samples were collected from 38 ms patients, 28 patients with other neurological diseases and 19 subjects without neurological diseases. using nested-pcr, the investigation focused on the presence of human herpes virus dna, includin ... | 2007 | 17177306 |
| an early event in the herpes simplex virus type-2 replication cycle is sufficient to induce chlamydia trachomatis persistence. | epidemiological studies have demonstrated that co-infections of herpes simplex virus type 2 (hsv-2) and chlamydia trachomatis occur in vivo. data from a tissue culture model of c. trachomatis/hsv-2 co-infection indicate that viral co-infection stimulates the formation of persistent chlamydiae. transmission electron microscopic (tem) analyses demonstrated that in both hela and hec-1b cells, co-infection caused developing chlamydiae to exhibit swollen, aberrantly shaped reticulate bodies (rbs), ch ... | 2007 | 17140408 |
| detection of herpes simplex virus type 1 in addition to epstein-bar virus in tonsils using a new multiplex polymerase chain reaction assay. | hsv-1, hsv-2, cmv, ebv, which are the members of the herpes virus family colonize and establish latent infection in human. although ebv is a well known virus most involved in recurrent bouts of acute tonsillitis, the role and possibility of hsv-1, hsv-2, and cmv for establishing infection in tonsils are not clear. the purpose of this study is to verify whether the tonsils might harbor the hsv-1, hsv-2, and cmv, in addition to ebv, in chronically hyperplastic nasopharyngeal lymphoid tissue. to ac ... | 2007 | 17141448 |
| herpes simplex virus type 2 (hsv-2) establishes latent infection in a different population of ganglionic neurons than hsv-1: role of latency-associated transcripts. | herpes simplex virus type 1 (hsv-1) and hsv-2 cause very similar acute infections but differ in their abilities to reactivate from trigeminal and dorsal root ganglia. to investigate differences in patterns of viral infection, we colabeled murine sensory ganglia for evidence of hsv infection and for the sensory neuron marker a5 or kh10. during acute infection, 7 to 10% of hsv-1 or hsv-2 antigen-positive neurons were a5 positive and 13 to 16% were kh10 positive, suggesting that both viruses reach ... | 2007 | 17151134 |
| acute retinal necrosis features, management, and outcomes. | to determine the viral diagnosis and factors affecting the visual outcome of eyes with acute retinal necrosis. | 2007 | 17184841 |
| herpes simplex virus type 2 and chlamydia trachomatis in adenocarcinoma of the uterine cervix. | adenocarcinoma of the uterine cervix (ac) occurs in 15-20% of primary cervical neoplasias. although some etiologic factors for squamous cell carcinoma are well defined, and its relationship with sexually transmitted disease as human papillomavirus (hpv) is established, we still do not know about the causative factors of most of ac besides hpv infection. | 2007 | 17188342 |
| synthesis and antiviral activity of c-fluoro-branched cyclopropyl nucleosides. | a series of novel fluorocyclopropyl nucleosides were synthesized starting from acetol using the simmons-smith reaction as a key reaction. all the nucleosides synthesized were assayed against several viruses. among the compounds synthesized, the uracil analogue 22 showed moderate anti-hcmv activity (10.61 microg/ml, in ad-169). | 2007 | 17188402 |
| trends in herpes simplex virus type 1 and 2 infections among patients diagnosed with genital herpes in a finnish sexually transmitted disease clinic, 1994-2002. | the objective of this study was to analyze the proportion of herpes simplex virus types 1 and 2 (hsv-1 and -2) in genital infections during a 9-year period (1994-2002) in a finnish sexually transmitted disease (std) clinic population. | 2007 | 17195754 |
| consequences of herpes simplex virus in pregnancy and their prevention. | new findings reveal that first-time infection of the mother is the most important factor for the transmission of genital herpes from mother to fetus/newborn. interventions based on these findings will lead to new management of the pregnant patient with genital herpes prior to pregnancy and measures to prevent the acquisition of herpes during pregnancy. | 2007 | 17197885 |
| virotherapy with a type 2 herpes simplex virus-derived oncolytic virus induces potent antitumor immunity against neuroblastoma. | we recently constructed an oncolytic virus from type 2 herpes simplex virus (hsv-2) that selectively targets and kills tumor cells with an activated ras signaling pathway. designated fuson-h2, this virus has shown several discrete killing mechanisms. here, we evaluated the antitumor immune responses after fuson-h2-mediated virotherapy in a syngeneic murine neuroblastoma model. | 2007 | 17200370 |
| validation of laboratory screening criteria for herpes simplex virus testing of cerebrospinal fluid. | most patients with herpes simplex virus (hsv) central nervous system (cns) infection have abnormal cerebrospinal fluid (csf) indices. therefore, we implemented screening criteria based on csf values and host immune status to guide testing. all csf samples submitted for hsv pcr analysis from january 1999 through december 2004 were included in the study. specimens from patients with human immunodeficiency virus, a history of transplants, an age of <2 years, a csf white blood cell count of >5 cells ... | 2007 | 17202281 |
| antibodies to infectious agents in individuals at ultra-high risk for psychosis. | while there is evidence that some cases of schizophrenia may be associated with microbial infections, the role of microbial agents has not been investigated in people with emerging psychosis. | 2007 | 17207471 |
| burden of infection and fat mass in healthy middle-aged men. | our aim was to study the effect of exposure to four infections on fat mass. | 2007 | 17228053 |
| seroprevalence of herpes simplex virus types 1 and 2 in pregnant women in the united states. | the purpose of this study was to determine seroprevalence of herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) in a national cross-sectional sample of pregnant women. | 2007 | 17240228 |
| acute retinal necrosis. | acute retinal necrosis (arn) is a rare disease that is usually caused by one of the three neurotropic human herpesviruses - herpes simplex virus type 1(hsv-1), hsv-2 and varicella-zoster virus (vzv). although much is known about the clinical course of the disease and its treatment and about the viruses that cause it, comparatively little is known about its pathogenesis. this article will review the history of arn, the typical clinical findings, and methods of diagnosis. information from studies ... | 2007 | 17264500 |
| susceptibility of ccr5-deficient mice to genital herpes simplex virus type 2 is linked to nk cell mobilization. | following genital herpes simplex virus type 2 (hsv-2) exposure, nk cells and t cells are mobilized to sites of infection to control viral replication and spread. the present investigation sought to determine the role of the chemokine receptor ccr5 in this process. mice deficient in ccr5 (ccr5-/-) displayed a significant reduction in cumulative survival following infection in comparison to wild-type, hsv-2-infected controls. associated with decreased resistance to viral infection, ccr5-/- mice yi ... | 2007 | 17267483 |
| herpes simplex virus type 2 and risk of intrapartum human immunodeficiency virus transmission. | to determine whether herpes simplex virus type 2 (hsv-2) infection was associated with risk of intrapartum human immunodeficiency virus type 1 (hiv-1) transmission and to define correlates of hsv-2 infection among hiv-1-seropositive pregnant women. | 2007 | 17267842 |
| an oncolytic virus derived from type 2 herpes simplex virus has potent therapeutic effect against metastatic ovarian cancer. | oncolytic viruses derived from herpes simplex virus (hsv) have shown considerable promise as antitumor agents against solid tumors including ovarian cancer. the current group of oncolytic hsvs was constructed exclusively from type 1 hsv. to exploit further the therapeutic potential of replication-selective viruses, we constructed an oncolytic virus from type 2 hsv by deleting the protein kinase domain of the viral icp10 gene, which targets the activated ras signaling pathway in tumor cells. in t ... | 2007 | 17290283 |
| reduction of hiv-1 rna levels with therapy to suppress herpes simplex virus. | epidemiologic data suggest that infection with herpes simplex virus type 2 (hsv-2) is associated with increased genital shedding of human immunodeficiency virus type 1 (hiv-1) rna and hiv-1 transmissibility. | 2007 | 17314338 |
| synergistic copathogens--hiv-1 and hsv-2. | 2007 | 17314346 | |
| negative mucosal synergy between herpes simplex type 2 and hiv in the female genital tract. | there is substantial epidemiological evidence that infection by herpes simplex virus type 2 (hsv2) enhances both hiv susceptibility and subsequent sexual transmission. both infections are extremely common in female sex workers (fsws) in sub-saharan africa, and up to 80% of new hiv infections in urban men in the region are acquired via transactional sex. the present study aimed to elucidate the mucosal immune interactions between hiv and hsv2 in the genital tract. | 2007 | 17314521 |
| two patients with the von szily reaction: herpetic keratitis and contralateral retinal necrosis. | to present two patients with prior unilateral, herpetic keratitis who developed acute retinal necrosis (arn) in the contralateral eye. these cases have noticeable similarities to the von szily reaction. this describes the development of a contralateral retinitis subsequent to an anterior chamber injection of herpes simplex virus (hsv). | 2007 | 17317412 |
| multifocal herpes simplex virus type 2 encephalitis in a patient with aids. | herpes simplex virus type 2 (hsv-2) infection commonly causes meningitis and genital herpes. we describe a rare case of brain stem encephalitis with cutaneous manifestations attributable to hsv-2 infection in a patient with hiv infection. | 2007 | 17323505 |
| testing for asymptomatic herpes simplex virus type 2: implications for pretest and post-test counseling. | 2007 | 17324349 | |
| virus-specific cd8+ t cells accumulate near sensory nerve endings in genital skin during subclinical hsv-2 reactivation. | cytotoxic cd8(+) t cells play a critical role in controlling herpes simplex virus (hsv) infection and reactivation. however, little is known about the spatiotemporal dynamics of cd8(+) t cells during hsv lesion evolution or about their involvement in immune surveillance after lesion resolution. using quantum dot-conjugated peptide-major histocompatibility complex multimers, we investigated the in vivo localization of hsv-2-specific cd8(+) t cells in sequential biopsies of human genital skin duri ... | 2007 | 17325200 |
| suppressive valacyclovir therapy: impact on the population spread of hsv-2 infection. | recent trial results demonstrate that the transmission probability of hsv-2 in monogamous couples is nearly halved by the use of valacyclovir as suppressive therapy. | 2007 | 17325600 |
| impact of a community sexually transmitted infection/hiv intervention project on female sex workers in five border provinces of vietnam. | to determine changes in the prevalence of sexually transmitted infection (sti)/hiv in female sex workers (fsws) after a community hiv prevention intervention project in five border provinces of vietnam. | 2007 | 17327262 |
| trio of studies makes headway in hiv battle. | 2007 | 17330014 | |
| design and work-up of a new molecular diagnostic assay based on real-time pcr. | in routine molecular diagnostics, real-time pcr has made a major impact because of the faster time to the result; decreased hands-on time; and virtual elimination of the major issue in the early days of pcr, sample contamination from previously amplified dna. the shorter time to the result for a real-time pcr assay means that a new diagnostic application may be developed relatively quickly. this chapter discusses the fluorescent chemistries typically used in molecular diagnostic applications and ... | 2007 | 17332644 |
| clinical inquiries. what's the best test for hsv-2 after exposure? | 2007 | 17343813 | |
| n-terminal mutants of herpes simplex virus type 2 gh are transported without gl but require gl for function. | glycoprotein h (gh) is conserved among all herpesviruses and is essential for virus entry and cell fusion along with gl, gb, and, in most alphaherpesviruses, gd. within the gh/gl heterodimer, it is thought that gh accounts for the fusion function and gl acts as a chaperone for the folding and transport of gh. here, we found that the n terminus of gh2 contains important elements involved in both its folding and its transport. our conclusions are based on the phenotypes of a series of gh deletion ... | 2007 | 17344290 |
| novel targets for the development of anti-herpes compounds. | herpes simplex virus type 1 (hsv-1) and herpes simplex virus type 2 (hsv-2) are members of the herpesviridae family. hsv infections have been known since ancient times and are one of the most common communicable diseases in humans. although infections are often subclinical, hsv can cause mild to severe diseases, especially in immunocompromised patients. herpes simplex viruses establish latency in the nuclei of neuronal cells and may reactivate, with or without symptoms, throughout the host's lif ... | 2007 | 17346207 |
| superior efficacy of helicase-primase inhibitor bay 57-1293 for herpes infection and latency in the guinea pig model of human genital herpes disease. | the efficacy of bay 57-1293, a novel non-nucleosidic inhibitor of herpes simplex virus 1 and 2 (hsv-1 and hsv-2), bovine herpesvirus and pseudorabies virus, was studied in the guinea pig model of genital herpes in comparison with the licensed drug valaciclovir (valtrex). early therapy with bay 57-1293 almost completely suppressed the symptoms of acute hsv-2 infection, and reduced virus shedding and viral load in the sacral dorsal root ganglia by up to three orders of magnitude, resulting in decr ... | 2007 | 17354650 |
| efficacy of a dish detergent in reducing populations of sti organisms in inoculated female condoms. | we assessed the efficacy of dish detergent in removing neisseria gonorrhoeae, hiv-1, herpes simplex virus type 2 and chlamydia trachomatis organisms from the surface of inoculated female condoms. the reductions achieved in organism counts with dish detergent were compared with those for household bleach and water. new (out-of-package) and pre-washed/re-lubricated female condoms were used. dish detergent was as efficacious as bleach in reducing organism counts from the surface of inoculated femal ... | 2007 | 17362555 |
| herpes simplex virus infection, massive pulmonary thromboembolism, and right atrial thrombi in a single patient: case report. | we report a 32-year-old man with herpes simplex virus encephalitis who developed massive pulmonary thromboembolism with mobile right atrial thrombi during treatment for this condition. it was not safe to use thrombolytic therapy because of the high risk of cerebral bleeding associated with encephalitis. the patient was initially treated at another center, but his condition deteriorated during nadroparin therapy and he was referred to our hospital. nadroparin was discontinued, and a continuous in ... | 2007 | 17362796 |
| synthesis of novel 2'-methyl carbovir analogues as potent antiviral agents. | in this study, the synthesis procedures of 2'-branched carbovir analogues were accomplished. the introduction of a methyl group in the requisite 2'-position was carried out by the addition of a carbonyl using isopropenyl magnesium bromide. the desired compound, cyclopentenol 10(beta), was synthesized via ring-closing metathesis using a second-generation grubbs' catalyst. the nucleosidic bases (adenine, cytosine, thymine, uracil, 5-fluorouracil and 5-iodouracil) were efficiently coupled using a p ... | 2007 | 17366731 |
| presence of herpes simplex virus on the oral mucosa in patients undergoing chemotherapy. | the aim of this study was to confirm the presence of herpes simplex virus type 1 and 2 on the oral mucosa, in patients undergoing chemotherapy, by means of polymerase chain reaction (pcr). | 2007 | 17373422 |
| [heterogeneity in the expression of female sexual commerce in mexico city]. | to evaluate the relationships among the socio-economic, demographic, and sexual behavior characteristics of commercial sexual workers (csw) and their work site. | 2007 | 17388032 |
| the role of common viral ocular pathogens in thygeson's superficial punctate keratitis. | the aetiology of thygeson's superficial punctate keratitis (tspk) remains elusive. a viral aetiology has been suggested by the absence of bacterial infection and clinical resemblance to other viral keratopathies. we report the results of polymerase chain reaction analysis for the detection of herpes simplex virus (hsv) 1 and 2, herpes zoster virus, varicella zoster virus (vzv) and adenovirus from corneal epithelial samples from patients with active signs and symptoms of tspk. | 2007 | 17389746 |
| by the way, doctor. for years, i was plagued by cold sores and took antiviral drugs to treat the outbreaks. but at a friend's suggestion, i started taking lysine every day, and it seems to prevent them altogether. what do you know about this supplement? | 2007 | 17393593 | |
| herpes simplex virus colitis complicating ulcerative colitis: a case report and brief review on superinfections. | in patients with inflammatory bowel disease herpes simplex virus infection has been described as a major cause of morbidity and mortality, especially in immunocompromised individuals. here we present the case of a 35-year old woman with an exacerbation of ulcerative colitis caused by herlpes simplex virus infection (hsv-2). the diagnosis was confirmed histologically following subtotal colectomy. after intravenous treatment with aciclovir for 2 weeks postoperative hematochezia stopped. herpes sim ... | 2007 | 21172183 |
| and the winner is...hiv treatment and prevention. | 2007 | 20210119 | |
| genetic comparison of human alphaherpesvirus genomes | human herpesviruses 1, 2, and 3 (herpes simplex virus 1 (hsv-1), herpes simplex virus 2 (hsv-2), and varicella-zoster virus (vzv)) have been classified as alphaherpesviruses based originally upon their biological properties, and subsequently on the sequences of their respective genomes (minson et al., 2000; pellett and roizman, in press). all of these viruses maintain latent infections in sensory ganglia, and can productively infect a variety of human cells, including the ... | 2007 | 21348084 |
| prevalence of herpes simplex virus types 1 and 2 and associated sociodemographic variables in pregnant women attending king fahd hospital of the university. | the risk factors associated with herpes simplex virus (hsv) seropositivity in pregnant women in saudi arabia are not known. this study was aimed at identifying the sociodemographic variables associated with seroprevalence of hsv-1 and hsv-2 in pregnant women in a saudi hospital. | 2007 | 23012136 |
| valacyclovir therapy to reduce recurrent genital herpes in pregnant women. | the purpose of this study was to estimate the efficacy of valacyclovir suppressive therapy in pregnant women with recurrent genital herpes. | 2006 | 16522412 |
| a randomized controlled trial of a replication defective (gh deletion) herpes simplex virus vaccine for the treatment of recurrent genital herpes among immunocompetent subjects. | a replication incompetent herpes virus lacking the glycoprotein h gene has been developed as a potential therapeutic vaccine for genital herpes. | 2006 | 16213066 |
| [spinal osteochondrosis, mesenchymal dysplasia and herpes infection]. | 36 intervertebrate disks (ivd) were studied in spinal osteochondrosis concurrent with herniation. expression of herpes simplex types 1 and 2 (hsv-1 and hsv-2) antigens, which was absent in ivd of the control group (autopsy cases without disk hernia). the similarity of herniation in osteochondrosis and cardiac mesenchymal dysplasia, a frequent concomitance of these processes and the presence of hsv-1 and hsv-2 antigens in the ivd cells and cardiac valves may indicate the same nature of these dise ... | 2006 | 17290888 |
| [genital herpes]. | 2006 | 17190019 | |
| no evidence of relation between maternal exposure to herpes simplex virus type 2 and risk of schizophrenia? | the authors examined whether maternal exposure to herpes virus type 2 is associated with risk for adult schizophrenia. | 2006 | 17151171 |
| [reversible posterior leukoencephalopathy syndrome in hashimoto's encephalopathy: a case report]. | a 45-year-old woman with breast cancer was admitted to our hospital because of several episodes of disturbed consciousness and generalized convulsions. while these symptoms resolved quickly, dysphagia and bilateral blepharoptosis persisted. neurological findings were improved by steroid therapy. mri on the first hospital day showed t2/flair high intensity lesions in both occipital lobes, but these lesions diminished on the 8th day, indicating reversible posterior leukoencephalopathy syndrome. a ... | 2006 | 17154034 |
| herpes simplex virus infections in preterm infants. | neonatal herpes simplex virus infections cause significant neonatal mortality and morbidity, but the course and prognosis in preterm infants is not well documented. we performed a retrospective review of herpes simplex virus infections at out institution within the first 30 days after birth in infants who were born at <37 weeks to help better define the symptoms and signs of herpes simplex virus infections in preterm infants and to assist in prognosis. | 2006 | 17142491 |
| [serologic examination for childhood herpes simplex virus infection]. | this study was designed to investigate the value of serologic examination in the diagnosis of childhood herpes simplex virus (hsv) infection. | 2006 | 17178039 |
| men who have sex with men and transgenders in mumbai, india: an emerging risk group for stis and hiv. | men who have sex with men and transgenders are an important risk group for sexually transmitted infections (stis) and human immunodeficiency virus (hiv). they have risky sexual behaviors but low risk perception. | 2006 | 17179617 |
| famciclovir: a review of its use in herpes zoster and genital and orolabial herpes. | famciclovir (famvir) is the oral prodrug of penciclovir, an agent that has demonstrated antiviral activity against herpes simplex viruses, type 1 (hsv-1) and 2 (hsv-2) [which cause orolabial and/or genital herpes simplex], and against varicella zoster virus (vzv) [a reactivation of which leads to herpes zoster]. famciclovir has efficacy similar to that of aciclovir (in immunocompetent or immunocompromised patients) or valaciclovir (in immunocompetent patients) in the treatment of herpes zoster, ... | 2006 | 17181386 |
| disseminated herpes simplex infection with cystic fibrosis: a case report. | a 6 months old female infant presented with history of fever, cough and severe respiratory distress. there was past history of recurrent attacks of pneumonia. she succumbed to the illness after a hospital stay of 7 days. postmortem revealed morphological evidence of cystic fibrosis along with herpes simplex infection of liver and adrenals. the co-existence of disseminated herpes simplex infection and cystic fibrosis is very rare. | 2006 | 17183874 |
| antibodies against six human herpesviruses in relation to seven cancers in black south africans: a case control study. | infections with certain human herpesviruses have been established as risk factors for some cancer types. for example, epstein-barr virus is considered a cause of burkitt's lymphoma and other immunosuppression related lymphomas, hodgkin lymphoma, and nasopharyngeal cancer. several other human herpesviruses have been linked to cancers but the totality of evidence is inconclusive. | 2006 | 17150131 |
| genital herpes. | 2006 | 17151051 | |
| cutting edge: plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ. | dendritic cells (dcs) are powerful apcs capable of activating naive lymphocytes. of the dc subfamilies, plasmacytoid dcs (pdcs) are unique in that they secrete high levels of type i ifns in response to viruses but their role in inducing adaptive immunity remains divisive. in this study, we examined the importance of pdcs and their ability to recognize a virus through tlr9 in immunity against genital hsv-2 infection. we show that a low number of pdcs survey the vaginal mucosa at steady state. upo ... | 2006 | 17114418 |
| primary herpes simplex virus type-2 infection as a cause of liver failure after liver transplantation. | we report a case of fatal primary herpes simplex virus type-2 (hsv-2) infection following liver transplantation, which manifested with fever and liver failure in the absence of muco-cutaneous disease. the infection was characterized by high levels of hsv dna in blood and the patient's inability to mount hsv-specific t-cell responses while showing preserved t-cell responses against cytomegalovirus. the donor was hsv-1 immunoglobulin g (igg) seronegative and hsv-2 igg seropositive, whereas the rec ... | 2006 | 17116138 |
| impact of suppressive herpes therapy on genital hiv-1 rna among women taking antiretroviral therapy: a randomized controlled trial. | to demonstrate a causal relationship between herpes simplex virus 2 (hsv-2) and increased genital hiv-1-rna shedding in women on haart. | 2006 | 17117016 |
| seroprevalence of herpes simplex virus-1 and -2 in attendees of a sexually transmitted infection clinic in singapore. | we studied the seroprevalance of hsv (herpes simplex virus)-1 and hsv-2 in outpatient attendees of a sexually transmitted infection (sti) clinic in singapore and examined their knowledge and attitudes towards hsv infection. | 2006 | 17112439 |
| bacterial vaginosis in women of low socioeconomic status living in slum areas in chennai, india. | bacterial vaginosis (bv) is a common cause of vaginitis among women of childbearing age. this study was performed to investigate the prevalence of bv and its association with sexually transmitted infections among 487 women of low socioeconomic status. blood, vaginal and endocervical swabs were tested for hiv, herpes simplex virus-2 (hsv-2), treponema pallidum, bv, chlamydia trachomatis, neisseria gonorrhoea and trichomonas vaginalis. of the women screened for bv, 120 (25, 95% ci 20.8-28.4) were ... | 2006 | 17112444 |
| 3'-carbon-substituted pyrimidine nucleosides having a 2',3'-dideoxy and 2',3'-didehydro-2',3'-dideoxy structure: synthesis and antiviral evaluation. | the bis(tributylstannyl) derivative of 2',3'-didehydro-2',3'-dideoxyuridine (d4u) underwent an anionic 5'-o-->3'-c stannyl migration to yield the 3'-tributylstannyl-d4u. this compound, with its vinylstannane structure, allowed ready access to the preparation of 3'-carbon-substituted analogues through the stille reaction. a conventional transformation of the uracil moiety of these d4u analogues led to the corresponding 2',3'-didehydro-2',3'-dideoxycytidine (d4c) counterparts. some 2',3'-dideoxycy ... | 2006 | 17066900 |
| early diffusion-weighted magnetic resonance imaging findings in neonatal herpes encephalitis. | neonatal herpes encephalitis is usually caused by herpes simplex virus type 2 and results in significant morbidity and mortality. imaging diagnosis with ultrasound, computed tomography scan and conventional magnetic resonance imaging may be normal in the early course of the disease. in this case diffusion-weighted magnetic resonance imaging detected the disease process earlier and better than the conventional t2-weighted or fluid-attenuated inversion recovery imaging sequences. the use of diffus ... | 2006 | 17096722 |
| recurrent aseptic meningitis associated with herpes simplex virus type 2. | 2006 | 17098119 | |
| beseiged. | 2006 | 17071158 | |
| seroprevalence of herpes simplex virus type 2 in multiple sclerosis. | it has been proposed that multiple sclerosis (ms) might be a sexually transmitted disorder. there is evidence that seropositivity to herpes simplex virus type 2 (hsv-2) correlates well with the number of sexual partners. accordingly, a raised overall hsv-2 seroprevalence in ms would lend support to this theory. | 2006 | 17083334 |
| [genital herpes]. | genital herpes simplex virus (hsv-1 and hsv-2) infection is an ulcerative, lifelong, recurring sexually transmitted disease of increasing epidemiologic worldwide importance. transmission occurs by close skin contact, usually during asymptomatic virus shedding. the virus persists in the dorsal root ganglion where it is not accessible to the host's immune system. the most important risk factor is a person's number of lifetime sex partners. the more extensive first-episode infection is followed by ... | 2006 | 17089142 |
| immunological profiles of patients with chronic myeloid leukaemia. i. state before the start of treatment. | in view of the increasing interest in the immunotherapy of cml it seems highly desirable to broaden the present knowledge on the immune reactivity of cml patients. a group of 24 patients and 24 healthy controls were studied for the total of 15 immunological parameters, including the prevalence of antibodies against human herpesviruses and papillomaviruses. to clearly discriminate between changes associated with the disease and those induced by the therapy, all patients were enrolled prior to the ... | 2006 | 17089915 |
| antiviral effect of aqueous extracts from species of the lamiaceae family against herpes simplex virus type 1 and type 2 in vitro. | aqueous extracts from species of the lamiaceae family were examined for their antiviral activity against herpes simplex virus (hsv). extracts from lemon balm (melissa officinalis), peppermint (mentha x piperita), prunella (prunella vulgaris), rosemary (rosmarinus officinalis), sage (salvia officinalis) and thyme (thymus vulgaris) were screened. their inhibitory activity against herpes simplex virus type 1 (hsv-1), type 2 (hsv-2) and an acyclovir-resistant strain of hsv-1 (acv (res)) was tested i ... | 2006 | 17091431 |
| longitudinal evaluation of herpes simplex virus dna load during episodes of herpes labialis. | few studies have performed sequential evaluation of the herpes simplex virus (hsv) load using quantitative pcr during episodes of herpes labialis. | 2006 | 17046320 |
| seroprevalence of herpes simplex virus type 1 and type 2 in turkey. | herpes simplex virus (hsv) infections are among the most common infectious diseases in humans. the prevalence of herpes simplex viruses type 1 (hsv-1) and type 2 (hsv-2) varies widely across the world. hsv-2 infection is the primary cause of genital herpes. it is highly prevalent in human populations in many parts of the world, and is the most common cause of genital ulcer disease worldwide. in spite of the large prevalence and growing incidence of herpes simplex infection (hsv-1 and hsv-2), rel ... | 2006 | 17062037 |
| hsv-2 antibodies in female sex workers in vietnam. | little information is available on the prevalence of herpes simplex type-2 (hsv-2) antibodies among groups at potential high risk of hiv in asia. this study was carried out to determine the prevalence of hsv-2 antibodies and correlates of hsv-2 infection in female sex workers (fsws) in border provinces of vietnam. nine hundred and four fsws in five border provinces of vietnam were interviewed about selected sociodemographic and behavioural characteristics, and information about partners by a sta ... | 2006 | 17062180 |
| comparison of different polymerase chain reaction methods for detection of herpes simplex virus types 1 and 2 encephalitis. | 2006 | 17047902 | |
| association of herpes simplex virus type 2 infection and syphilis with human immunodeficiency virus infection among men who have sex with men in peru. | we evaluated associations between human immunodeficiency virus (hiv) infection, herpes simplex virus type 2 (hsv-2) infection, and syphilis among men who have sex with men (msm) in peru. | 2006 | 17054077 |
| famciclovir for the treatment of recurrent genital herpes: a clinical and pharmacological perspective. | herpes simplex virus is one of the most common causes of genital ulcer disease worldwide. herpes simplex virus-2 is the more common cause of genital herpes, a chronic infection that is characterised by periodic reactivation, with the capacity to produce recurrent symptomatic disease in the host (e.g., vesicular eruption), as well as intermittent asymptomatic shedding. relapsing episodes may be physically and psychologically distressing. shedding accounts for the majority of cases of transmission ... | 2006 | 17059383 |
| association between hsv-2 and hiv-1 viral load in semen, cervico-vaginal secretions and genital ulcers of thai men and women. | we studied the association between herpes simplex virus type-2 (hsv-2) and hiv-1 viralload in plasma, semen, cervico-vaginal secretions and genital ulcers. forty-seven (68%) men and 57 (80%) women were hsv-2 antibody positive, of whom 12 (26%, 95% confidence interval [ci] 20, 32) and five (8%, 95% ci 4, 12), respectively, had hsv-2 genital shedding detected by polymerase chain reaction. the mean hiv-1 seminal and cervico-vaginal viral loads did not differ significantly according to the presence ... | 2006 | 17059638 |
| microarray assay for detection and discrimination of orthopoxvirus species. | a microarray method was developed for simultaneous detection and identification of six species of orthopoxvirus (opv) including variola, monkeypox, cowpox, camelpox, vaccinia, and ectromelia viruses. the method allowed us to discriminate opv species from varicella-zoster virus (vzv), herpes simplex 1 virus (hsv-1), and herpes simplex 2 virus (hsv-2) that cause infections with clinical manifestations similar to opv infections. the nucleotide sequences of the c23l/b29r and the b19r genes identifie ... | 2006 | 16927285 |
| effect of valacyclovir on viral shedding in immunocompetent patients with recurrent herpes simplex virus 2 genital herpes: a us-based randomized, double-blind, placebo-controlled clinical trial. | to determine the efficacy of daily suppressive therapy with a 1-g dose of valacyclovir in reducing total (clinical and subclinical) herpes simplex virus 2 (hsv-2) shedding compared with placebo in immunocompetent patients diagnosed as having recurrent hsv-2 genital herpes. | 2006 | 17036557 |
| herpes simplex and epstein-barr virus lymphadenitis in a patient with chronic lymphocytic leukemia treated with fludarabine. | multiple herpes virus co-infection is a very rare complication in patients with chronic lymphocytic leukemia (cll). we describe a patient with a cll who developed an herpes virus lymphadenitis. inmunohistochemical study was positive for hsv-1, hsv-2, and epstein-barr virus (ebv). the coinfection of ebv with a profile of expresion of viral latent genes type iii, is usually seen in inmunodepressed patients. to the best of our knowledge, this is the first reported case of a multiple human herpes vi ... | 2006 | 17044837 |
| hiv among pregnant women in moshi tanzania: the role of sexual behavior, male partner characteristics and sexually transmitted infections. | women continue to be disproportionately affected by hiv in tanzania, and factors contributing to this situation need to be identified. the objective of this study was to determine social, behavioral and biological risk factors of hiv infection among pregnant women in moshi urban, tanzania. in 2002-2004, consenting women (n = 2654), attending primary health clinics for routine antenatal care were interviewed, examined and biological samples collected for diagnosis of hiv and other sexually transm ... | 2006 | 17044932 |
| acidform inactivates herpes simplex virus and prevents genital herpes in a mouse model: optimal candidate for microbicide combinations. | the acidic vaginal milieu is presumed to inactivate pathogens but is neutralized by semen. this notion fostered the development of acid-buffering products, such as acidform (developed by program for topical prevention of conception and disease, rush university, and licensed by instead), as microbicides. however, the extent and mechanism of protective activity provided by buffering gels is not known. exposure of herpes simplex virus (hsv) to ph 4.5 or lower irreversibly inactivated hsv and reduce ... | 2006 | 16941346 |
| chapter 1: hpv in the etiology of human cancer. | the causal role of human papillomavirus (hpv) in all cancers of the uterine cervix has been firmly established biologically and epidemiologically. most cancers of the vagina and anus are likewise caused by hpv, as are a fraction of cancers of the vulva, penis, and oropharynx. hpv-16 and -18 account for about 70% of cancers of the cervix, vagina, and anus and for about 30-40% of cancers of the vulva, penis, and oropharynx. other cancers causally linked to hpv are non-melanoma skin cancer and canc ... | 2006 | 16949995 |
| role of bcl-2 expression for productive herpes simplex virus 2 replication. | herpes simplex viruses infect a variety of cells in vitro. however, not all infected cells sustain a fully productive replication of these viruses. we have shown that, in u937 monocytoid cells, herpes simplex virus 2 (hsv-2) causes a low-productive infection characterized by apoptosis as cytopathic effect at a late stage of infection. this effect was associated with a down-regulation of the bcl-2 protein. we therefore asked whether destabilization of bcl-2 expression could act as a limiting fact ... | 2006 | 16950491 |
| invader plus method detects herpes simplex virus in cerebrospinal fluid and simultaneously differentiates types 1 and 2. | we report here on the development and validation of a prototype invader plus method for the qualitative detection of herpes simplex virus types 1 and 2 in cerebrospinal fluid (csf). the method combines pcr and invader techniques in a single, closed-tube, continuous-reaction format that gives an analytical sensitivity of approximately 10 copies per reaction. the clinical sensitivity and specificity were 100.0% and 98.6%, respectively, when the results of the method were validated against the resu ... | 2006 | 16954297 |
| universal prenatal herpes screening is a bad idea in pregnancy. | 2006 | 16962863 | |
| herpes simplex virus in the saliva of peripheral bell's palsy patients. | the first herpes virus to be described was types 1 and 2, whose denomination is herpes simplex 1 and 2 or hsv-1 and hsv-2. these viruses have specific biological characteristics, such as the ability to cause different kinds of diseases, as well as to establish hosts latent or persistent lifetime infections and also of being reactivated, causing lesions that can be located at the same site of the initial primary infection or close to it. it is suggested that this virus reactivation in the genicul ... | 2006 | 16917546 |
| influence of storage temperature on the stability of hiv-1 rna and hsv-2 dna in cervicovaginal secretions collected by vaginal washing. | variability in the handling of samples of genital secretions prior to quantitation of hiv-1 rna and hsv dna may profoundly affect both the detection and quantitation of these nucleic acids. over 144 h, we evaluated, the influence of storage temperature (4 degrees c, 20 degrees c, 30 degrees c) on the quantity of hiv-1 rna and hsv-2 dna in hiv and hsv negative cervicovaginal lavage pools spiked with known amounts of hiv-1 and hsv-2 and in hiv-1 and hsv-2 co-infected cervicovaginal lavage pools. t ... | 2006 | 16919788 |
| trends in herpes simplex virus type 1 and type 2 seroprevalence in the united states. | herpes simplex virus type 1 (hsv-1) and type 2 are common infections worldwide. herpes simplex virus type 2 (hsv-2) is the cause of most genital herpes and is almost always sexually transmitted. in contrast, hsv-1 is usually transmitted during childhood via nonsexual contacts. preexisting hsv-1 antibodies can alleviate clinical manifestations of subsequently acquired hsv-2. furthermore, hsv-1 has become an important cause of genital herpes in some developed countries. | 2006 | 16926356 |
| [perianal herpetic ulcers in a patient with previously undiagnosed human immunodeficiency virus]. | 2006 | 16978553 | |
| the microenvironment of vulvar skin in women with symptomatic and asymptomatic herpes simplex virus type 2 (hsv-2) infection. | it is not known why some individuals infected with herpes simplex virus type 2 (hsv-2), experience frequent recurrences, while most of those infected have a completely silent infection. | 2006 | 16987263 |
| high incidence of genotypic variance between sequential herpes simplex virus type 2 isolates from hiv-1-seropositive patients with recurrent genital herpes. | we developed a polymerase chain reaction (pcr) method, based on strain-to-strain variation of dna repeats in the herpes simplex virus type 2 (hsv-2) genes us1 and us12, to genotype hsv-2 strains and determine the incidence and risk factors associated with hsv-2 superinfection in patients with recurrent genital herpes (rgh). forty-seven (92%) of 51 unrelated hsv-2 isolates could be distinguished. genotyping of sequential hsv-2 isolates showed a different genotype in all of the 11 human immunodefi ... | 2006 | 16991086 |
| primary treatment of acute retinal necrosis with oral antiviral therapy. | to explore the possibility of oral antiviral therapy in lieu of intravenous acyclovir for treating acute retinal necrosis (arn), a necrotizing retinopathy caused by herpes simplex virus type 1 or 2 or by varicella zoster virus. | 2006 | 16996614 |
| 9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. synthesis and antiviral activity of all stereoisomers1. | all stereoisomers of adenine and guanine methylene-3-fluoromethylenecyclopropane analogues of nucleosides 9a, 9b, 10a, 10b, 11a, 11b, 12a, and 12b were synthesized and their antiviral activities were evaluated. a highly convergent approach permitted the synthesis of all these analogues using a single intermediate 15. reaction of aldehyde 13 with fluorotrichloromethane and tri-n-butylphosphine gave fluoroalkenes 14a+14b (83:17). addition of carbene derived from ethyl diazoacetate gave cyclopropan ... | 2006 | 17004726 |
| induction of innate immunity against herpes simplex virus type 2 infection via local delivery of toll-like receptor ligands correlates with beta interferon production. | toll-like receptors (tlrs) constitute a family of innate receptors that recognize and respond to a wide spectrum of microorganisms, including fungi, bacteria, viruses, and protozoa. previous studies have demonstrated that ligands for tlr3 and tlr9 induce potent innate antiviral responses against herpes simplex virus type 2 (hsv-2). however, the factor(s) involved in this innate protection is not well-defined. here we report that production of beta interferon (ifn-beta) but not production of ifn- ... | 2006 | 17005672 |
| quantification of poly(i:c)-mediated protection against genital herpes simplex virus type 2 infection. | alternative strategies for controlling the growing herpes simplex virus type 2 (hsv-2) epidemic are needed. a novel class of immunomodulatory microbicides has shown promise as antiherpetics, including intravaginally applied cpg-containing oligodeoxynucleotides that stimulate toll-like receptor 9 (tlr9). in the current study, we quantified protection against experimental genital hsv-2 infection provided by an alternative nucleic acid-based tlr agonist, polyinosine-poly(c) (pic) (tlr3 agonist). us ... | 2006 | 17005677 |