Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| n-terminal mutants of herpes simplex virus type 2 gh are transported without gl but require gl for function. | glycoprotein h (gh) is conserved among all herpesviruses and is essential for virus entry and cell fusion along with gl, gb, and, in most alphaherpesviruses, gd. within the gh/gl heterodimer, it is thought that gh accounts for the fusion function and gl acts as a chaperone for the folding and transport of gh. here, we found that the n terminus of gh2 contains important elements involved in both its folding and its transport. our conclusions are based on the phenotypes of a series of gh deletion ... | 2007 | 17344290 |
| clinical inquiries. what's the best test for hsv-2 after exposure? | 2007 | 17343813 | |
| [modern views concerning the part played by herpes simplex type 2 virus in the pathogenesis of cancer of the cervix]. | recent views on the relationship between carcinoma of the cervix and the herpes virus are presented. while the question is still very open, it can nervetheless be suggested that the type 2 virus plays a part in the pathogenesis of the tumour. sexual relationships, pregnancy and hormones are important factors in this connection. | 1973 | 17343163 |
| design and work-up of a new molecular diagnostic assay based on real-time pcr. | in routine molecular diagnostics, real-time pcr has made a major impact because of the faster time to the result; decreased hands-on time; and virtual elimination of the major issue in the early days of pcr, sample contamination from previously amplified dna. the shorter time to the result for a real-time pcr assay means that a new diagnostic application may be developed relatively quickly. this chapter discusses the fluorescent chemistries typically used in molecular diagnostic applications and ... | 2007 | 17332644 |
| trio of studies makes headway in hiv battle. | 2007 | 17330014 | |
| impact of a community sexually transmitted infection/hiv intervention project on female sex workers in five border provinces of vietnam. | to determine changes in the prevalence of sexually transmitted infection (sti)/hiv in female sex workers (fsws) after a community hiv prevention intervention project in five border provinces of vietnam. | 2007 | 17327262 |
| suppressive valacyclovir therapy: impact on the population spread of hsv-2 infection. | recent trial results demonstrate that the transmission probability of hsv-2 in monogamous couples is nearly halved by the use of valacyclovir as suppressive therapy. | 2007 | 17325600 |
| virus-specific cd8+ t cells accumulate near sensory nerve endings in genital skin during subclinical hsv-2 reactivation. | cytotoxic cd8(+) t cells play a critical role in controlling herpes simplex virus (hsv) infection and reactivation. however, little is known about the spatiotemporal dynamics of cd8(+) t cells during hsv lesion evolution or about their involvement in immune surveillance after lesion resolution. using quantum dot-conjugated peptide-major histocompatibility complex multimers, we investigated the in vivo localization of hsv-2-specific cd8(+) t cells in sequential biopsies of human genital skin duri ... | 2007 | 17325200 |
| testing for asymptomatic herpes simplex virus type 2: implications for pretest and post-test counseling. | 2007 | 17324349 | |
| multifocal herpes simplex virus type 2 encephalitis in a patient with aids. | herpes simplex virus type 2 (hsv-2) infection commonly causes meningitis and genital herpes. we describe a rare case of brain stem encephalitis with cutaneous manifestations attributable to hsv-2 infection in a patient with hiv infection. | 2007 | 17323505 |
| two patients with the von szily reaction: herpetic keratitis and contralateral retinal necrosis. | to present two patients with prior unilateral, herpetic keratitis who developed acute retinal necrosis (arn) in the contralateral eye. these cases have noticeable similarities to the von szily reaction. this describes the development of a contralateral retinitis subsequent to an anterior chamber injection of herpes simplex virus (hsv). | 2007 | 17317412 |
| negative mucosal synergy between herpes simplex type 2 and hiv in the female genital tract. | there is substantial epidemiological evidence that infection by herpes simplex virus type 2 (hsv2) enhances both hiv susceptibility and subsequent sexual transmission. both infections are extremely common in female sex workers (fsws) in sub-saharan africa, and up to 80% of new hiv infections in urban men in the region are acquired via transactional sex. the present study aimed to elucidate the mucosal immune interactions between hiv and hsv2 in the genital tract. | 2007 | 17314521 |
| synergistic copathogens--hiv-1 and hsv-2. | 2007 | 17314346 | |
| reduction of hiv-1 rna levels with therapy to suppress herpes simplex virus. | epidemiologic data suggest that infection with herpes simplex virus type 2 (hsv-2) is associated with increased genital shedding of human immunodeficiency virus type 1 (hiv-1) rna and hiv-1 transmissibility. | 2007 | 17314338 |
| [spinal osteochondrosis, mesenchymal dysplasia and herpes infection]. | 36 intervertebrate disks (ivd) were studied in spinal osteochondrosis concurrent with herniation. expression of herpes simplex types 1 and 2 (hsv-1 and hsv-2) antigens, which was absent in ivd of the control group (autopsy cases without disk hernia). the similarity of herniation in osteochondrosis and cardiac mesenchymal dysplasia, a frequent concomitance of these processes and the presence of hsv-1 and hsv-2 antigens in the ivd cells and cardiac valves may indicate the same nature of these dise ... | 2006 | 17290888 |
| an oncolytic virus derived from type 2 herpes simplex virus has potent therapeutic effect against metastatic ovarian cancer. | oncolytic viruses derived from herpes simplex virus (hsv) have shown considerable promise as antitumor agents against solid tumors including ovarian cancer. the current group of oncolytic hsvs was constructed exclusively from type 1 hsv. to exploit further the therapeutic potential of replication-selective viruses, we constructed an oncolytic virus from type 2 hsv by deleting the protein kinase domain of the viral icp10 gene, which targets the activated ras signaling pathway in tumor cells. in t ... | 2007 | 17290283 |
| clinical and therapeutic issues for herpes simplex virus-2 and hiv co-infection. | a synergy between hiv type-1 (hiv-1) and herpes simplex virus-2 (hsv-2) has been demonstrated in many epidemiological and clinical studies over the last decade. hiv-1 infection exacerbates the clinical impact and frequency of hsv-2 reactivation events; furthermore, hsv-2 infection exacerbates the risk of hiv acquisition and transmission and may accentuate hiv disease progression. in order to maximise the impact of existing and future therapeutic and preventive interventions, this article reviews ... | 2007 | 17284082 |
| hiv-1, sexually transmitted infections, and sexual behavior trends among men who have sex with men in lima, peru. | to assess and estimate trends in hiv, sexually transmitted infections (stis), and sexual behavior among men who have sex with men (msm) in lima, peru. | 2007 | 17279049 |
| seroprevalence of hsv1 and hsv2 infections in family planning clinic attenders. | few studies from india documented seroprevalence of hsv 1 and 2 infection in different population groups. we determined hsv 1 and 2 seroprevalence in a cohort of adults 16-40 year of age, attending the family planning clinic. for the overall study population, 63% were seropositives, 33.3% for hsv 1 alone. 16.6% for hsv 2 and 13.3% had mixed infection. by the statistical analysis, the mean age difference between the two sexes for either infection was not significant. hsv-2 seroprevalence was asso ... | 2005 | 17278662 |
| herpes simplex virus type 2 and risk of intrapartum human immunodeficiency virus transmission. | to determine whether herpes simplex virus type 2 (hsv-2) infection was associated with risk of intrapartum human immunodeficiency virus type 1 (hiv-1) transmission and to define correlates of hsv-2 infection among hiv-1-seropositive pregnant women. | 2007 | 17267842 |
| susceptibility of ccr5-deficient mice to genital herpes simplex virus type 2 is linked to nk cell mobilization. | following genital herpes simplex virus type 2 (hsv-2) exposure, nk cells and t cells are mobilized to sites of infection to control viral replication and spread. the present investigation sought to determine the role of the chemokine receptor ccr5 in this process. mice deficient in ccr5 (ccr5-/-) displayed a significant reduction in cumulative survival following infection in comparison to wild-type, hsv-2-infected controls. associated with decreased resistance to viral infection, ccr5-/- mice yi ... | 2007 | 17267483 |
| induction of strong antitumor immunity by an hsv-2-based oncolytic virus in a murine mammary tumor model. | oncolytic viruses have shown considerable promise for the treatment of solid tumors. in previous studies, we demonstrated that a novel oncolytic virus (fuson-h2), constructed by replacing the serine/threonine protein kinase (pk) domain of the icp10 gene of type 2 herpes simplex virus (hsv-2) with the gene encoding the green fluorescent protein, can selectively replicate in and thus lyse tumor cells. 4t1 tumor cells are weakly immunogenic and the mammary tumors derived from them aggressively meta ... | 2007 | 17266169 |
| acute retinal necrosis. | acute retinal necrosis (arn) is a rare disease that is usually caused by one of the three neurotropic human herpesviruses - herpes simplex virus type 1(hsv-1), hsv-2 and varicella-zoster virus (vzv). although much is known about the clinical course of the disease and its treatment and about the viruses that cause it, comparatively little is known about its pathogenesis. this article will review the history of arn, the typical clinical findings, and methods of diagnosis. information from studies ... | 2007 | 17264500 |
| concurrent cmv and ebv dnaemia is significantly correlated with a delay in the response to haart in treatment-naive hiv type 1-positive patients. | the purpose of this study was to assess the qualitative single and multiple herpes virus dnaemia in the peripheral blood leukocytes (pbls) of hiv-1-positive patients and its impact on the response to highly active antiretroviral therapy (haart) and immune reconstitution. all (163) hiv-1-positive patients attending "syngros aids referral center" from november 2000 to february 2001 were recruited. cmv, hsv-1, hsv-2, ebv, and hhv-8 dna were detected in pbls by polymerase chain reaction (pcr). patie ... | 2007 | 17263627 |
| addition of a c-terminal cysteine improves the anti-herpes simplex virus activity of a peptide containing the human immunodeficiency virus type 1 tat protein transduction domain. | previous studies have shown that peptides containing the protein transduction domain (ptd) of the human immunodeficiency virus tat protein (grkkrrqrrr) were effective inhibitors of herpes simplex virus type 1 (hsv-1) entry (h. bultmann and c. r. brandt, j. biol. chem. 277:36018-36023, 2002). we now show that the addition of a single cysteine residue to the c terminus of the tat ptd (tat-c peptide) improves the antiviral activity against hsv-1 and hsv-2. the principle effect of adding the cystein ... | 2007 | 17261627 |
| development of a novel internal control for a real-time pcr for hsv dna types 1 and 2. | detection of herpes simplex virus types 1 and 2 dna by polymerase chain reaction (pcr) is the method of choice in many laboratories due to improved sensitivity, specificity and turnaround times compared with culture and antigen detection. however, internal controls need to be employed to ensure that inhibitors in samples do not produce false negative results. | 2007 | 17254842 |
| corneal buttons obtained from patients with hsk harbor high copy numbers of the hsv genome. | to detect herpes simplex virus (hsv) genome in the cornea, we sampled the limbal corneas and scleras of the imported eye bank eyes and recipient's corneal buttons and quantitated hsv genome in them by real-time polymerase chain reaction (pcr). | 2007 | 17251811 |
| the ribonucleotide reductase domain of the r1 subunit of herpes simplex virus type 2 ribonucleotide reductase is essential for r1 antiapoptotic function. | the r1 subunit (icp10) of herpes simplex virus type 2 (hsv-2) ribonucleotide reductase (rr), which in addition to its c-terminal reductase domain possesses a unique n-terminal domain of about 400 aa, protects cells against apoptosis. as the nh(2) domain on its own is not antiapoptotic, it has been postulated that both domains of r1 or part(s) of them could be necessary for this function. here, n- and c-terminal deletions were introduced in hsv-2 r1 to map the domain(s) involved in its antiapopto ... | 2007 | 17251554 |
| five years of progress on cyclin-dependent kinases and other cellular proteins as potential targets for antiviral drugs. | in 1997-1998, the pharmacological cyclin-dependent kinase (cdk) inhibitors (pcis) were independently discovered to inhibit replication of human cytomegalovirus, herpes simplex virus type 1 and hiv-1. the results from small clinical trials against cancer were then suggesting that pcis could be safe enough to be used clinically. it was thus hypothesized that pcis could have the potential to be developed as novel antivirals targeting cellular proteins. consequently, antiviral chemistry & chemothera ... | 2006 | 17249245 |
| seroprevalence of herpes simplex virus types 1 and 2 in pregnant women in the united states. | the purpose of this study was to determine seroprevalence of herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) in a national cross-sectional sample of pregnant women. | 2007 | 17240228 |
| the correlation between neurological evaluations and neurological outcome in acute encephalitis: a hospital-based study. | acute encephalitis is a common cns infectious disease in children. however, there are limited studies concerning about the correlation between the clinical evaluations and neurological outcome. to investigate the value of neurological evaluations, and the correlation between these evaluations and neurological outcomes of acute encephalitis, in the present study we retrospectively evaluated the neurological outcome of 0- to 16-year-old children with encephalitis or meningoencephalitis between 199 ... | 2007 | 17240177 |
| evaluation of neurovirulence and biodistribution of venezuelan equine encephalitis replicon particles expressing herpes simplex virus type 2 glycoprotein d. | the safety of a propagation-defective venezuelan equine encephalitis virus (veev) replicon particle vaccine was examined in mice. after intracranial inoculation we observed approximately 5% body weight loss, modest inflammatory changes in the brain, genome replication, and foreign gene expression. these changes were transient and significantly less severe than those caused by tc-83, a live-attenuated vaccinal strain of veev that has been safely used to immunize military personnel and laboratory ... | 2007 | 17239997 |
| predictors of herpes simplex virus type 2 prevalence and incidence among bar and hotel workers in moshi, tanzania. | herpes simplex virus (hsv) type 2 increases the risk of human immunodeficiency virus (hiv) infection, and, in regions with high prevalence of both viruses, control of hsv-2 may be an effective method of hiv prevention. identification of modifiable factors for prevention of hsv-2 infection is essential. we conducted this study among female bar and hotel workers in moshi, tanzania. | 2007 | 17230408 |
| prevalence of sexually transmitted infections in female sex workers in athens, greece - 2005. | there is little data on the prevalence of stis in female sex workers, greek and immigrants, working in athens, greece, since most of them work without any form of official license. our aim was to establish the prevalence of stis in asymptomatic legal greek and immigrant female sex workers in athens, greece. the study involved an evaluation of gonococcal and chlamydial infection, early infectious syphilis, hiv infection, hsv-2 infection, hepatitis b and c in 299 female sex workers who applied for ... | 2006 | 17229607 |
| burden of infection and fat mass in healthy middle-aged men. | our aim was to study the effect of exposure to four infections on fat mass. | 2007 | 17228053 |
| short-course therapy for recurrent genital herpes and herpes labialis. | 2007 | 17217895 | |
| antibodies to infectious agents in individuals at ultra-high risk for psychosis. | while there is evidence that some cases of schizophrenia may be associated with microbial infections, the role of microbial agents has not been investigated in people with emerging psychosis. | 2007 | 17207471 |
| hsv-2- and hiv-1- permissive cell lines co-infected by hsv-2 and hiv-1 co-replicate hsv-2 and hiv-1 without production of hsv-2/hiv-1 pseudotype particles. | herpes simplex virus type 2 (hsv-2) is a major cofactor of human immunodeficiency virus type 1 (hiv-1) sexual acquisition and transmission. in the present study, we investigated whether hiv-1 and hsv-2 may interact at the cellular level by forming hiv-1 hybrid virions pseudotyped with hsv-2 envelope glycoproteins, as was previously reported for hsv type 1. | 2007 | 17207276 |
| [effect of huangbai liquid on expression of human beta-defensin-2 mrna in skin lesions of patients with recurrent genital herpes]. | to investigate the expression of human beta-defensin-2 (hbd-2) mrna in skin lesions of patients with recurrent genital herpes (rgh) and the effect of huangbai liquid (hl) on it. | 2006 | 17205827 |
| [herpes simplex virus vaccine studies: from past to present]. | the dramatical increase in the prevalence of herpes simplex virus (hsv) infections and the significant physical and psychosocial morbidity of hsv type 2 infections, generate the need for an efficacious hsv vaccine. the most important properties of hsvs that should be targeted for a successful vaccine are neuronal invasion, latency and reactivation in spite of specific host immune responses. the major expectation for an ideal hsv vaccine candidate is to induce sterilizing immunity, which must be ... | 2006 | 17205702 |
| selective defect in plasmacyoid dendritic cell function in a patient with aids-associated atypical genital herpes simplex vegetans treated with imiquimod. | we report a case of acquired immunodeficiency syndrome (aids)-associated, acyclovir-refractory genital herpes infection treated with topical imidazoquinoline therapy. the patient's plasmacytoid dendritic cells made a robust interferon- alpha response following in vitro stimulation with imidazoquinoline but not with herpes simplex virus. we hypothesize that disease resulting from defective herpes simplex virus-stimulated interferon- alpha may be overcome by stimulating intact alternative pathways ... | 2007 | 17205432 |
| validation of laboratory screening criteria for herpes simplex virus testing of cerebrospinal fluid. | most patients with herpes simplex virus (hsv) central nervous system (cns) infection have abnormal cerebrospinal fluid (csf) indices. therefore, we implemented screening criteria based on csf values and host immune status to guide testing. all csf samples submitted for hsv pcr analysis from january 1999 through december 2004 were included in the study. specimens from patients with human immunodeficiency virus, a history of transplants, an age of <2 years, a csf white blood cell count of >5 cells ... | 2007 | 17202281 |
| virotherapy with a type 2 herpes simplex virus-derived oncolytic virus induces potent antitumor immunity against neuroblastoma. | we recently constructed an oncolytic virus from type 2 herpes simplex virus (hsv-2) that selectively targets and kills tumor cells with an activated ras signaling pathway. designated fuson-h2, this virus has shown several discrete killing mechanisms. here, we evaluated the antitumor immune responses after fuson-h2-mediated virotherapy in a syngeneic murine neuroblastoma model. | 2007 | 17200370 |
| consequences of herpes simplex virus in pregnancy and their prevention. | new findings reveal that first-time infection of the mother is the most important factor for the transmission of genital herpes from mother to fetus/newborn. interventions based on these findings will lead to new management of the pregnant patient with genital herpes prior to pregnancy and measures to prevent the acquisition of herpes during pregnancy. | 2007 | 17197885 |
| trends in herpes simplex virus type 1 and 2 infections among patients diagnosed with genital herpes in a finnish sexually transmitted disease clinic, 1994-2002. | the objective of this study was to analyze the proportion of herpes simplex virus types 1 and 2 (hsv-1 and -2) in genital infections during a 9-year period (1994-2002) in a finnish sexually transmitted disease (std) clinic population. | 2007 | 17195754 |
| antiherpetic flavones from the heartwood of artocarpus gomezianus. | the heartwood of artocarpus gomezianus was investigated for anti-herpetic principles. during the course of the separation, a new compound, artogomezianone (1), was isolated, along with the known compounds cycloartocarpin (2), isocyclomorusin (3), artocarpin (4), norcycloartocarpin (5), norartocarpetin (6), and oxyresveratrol (7). evaluation of these isolates for inhibitory effects against herpes simplex virus (hsv) types 1 and 2 was carried out using the inactivation method. compounds 2, 3, 6 an ... | 2006 | 17193228 |
| main structural and stereochemical aspects of the antiherpetic activity of nonahydroxyterphenoyl-containing c-glycosidic ellagitannins. | antiherpetic evaluation of five nonahydroxyterphenoyl-containing c-glycosidic ellagitannins, castalagin (1), vescalagin (2), grandinin (3), roburin b (5), and roburin d (7), was performed in cultured cells against four hsv-1 and hsv-2 strains, two of which were resistant to acyclovir. all five ellagitannins displayed significant anti-hsv activities against the acyclovir-resistant mutants, but the monomeric structures 1-3 were more active than the dimers 5 and 7. vescalagin (2) stands out among t ... | 2004 | 17191843 |
| [genital herpes]. | 2006 | 17190019 | |
| synthesis and antiviral activity of c-fluoro-branched cyclopropyl nucleosides. | a series of novel fluorocyclopropyl nucleosides were synthesized starting from acetol using the simmons-smith reaction as a key reaction. all the nucleosides synthesized were assayed against several viruses. among the compounds synthesized, the uracil analogue 22 showed moderate anti-hcmv activity (10.61 microg/ml, in ad-169). | 2007 | 17188402 |
| herpes simplex virus type 2 and chlamydia trachomatis in adenocarcinoma of the uterine cervix. | adenocarcinoma of the uterine cervix (ac) occurs in 15-20% of primary cervical neoplasias. although some etiologic factors for squamous cell carcinoma are well defined, and its relationship with sexually transmitted disease as human papillomavirus (hpv) is established, we still do not know about the causative factors of most of ac besides hpv infection. | 2007 | 17188342 |
| acute retinal necrosis features, management, and outcomes. | to determine the viral diagnosis and factors affecting the visual outcome of eyes with acute retinal necrosis. | 2007 | 17184841 |
| disseminated herpes simplex infection with cystic fibrosis: a case report. | a 6 months old female infant presented with history of fever, cough and severe respiratory distress. there was past history of recurrent attacks of pneumonia. she succumbed to the illness after a hospital stay of 7 days. postmortem revealed morphological evidence of cystic fibrosis along with herpes simplex infection of liver and adrenals. the co-existence of disseminated herpes simplex infection and cystic fibrosis is very rare. | 2006 | 17183874 |
| famciclovir: a review of its use in herpes zoster and genital and orolabial herpes. | famciclovir (famvir) is the oral prodrug of penciclovir, an agent that has demonstrated antiviral activity against herpes simplex viruses, type 1 (hsv-1) and 2 (hsv-2) [which cause orolabial and/or genital herpes simplex], and against varicella zoster virus (vzv) [a reactivation of which leads to herpes zoster]. famciclovir has efficacy similar to that of aciclovir (in immunocompetent or immunocompromised patients) or valaciclovir (in immunocompetent patients) in the treatment of herpes zoster, ... | 2006 | 17181386 |
| men who have sex with men and transgenders in mumbai, india: an emerging risk group for stis and hiv. | men who have sex with men and transgenders are an important risk group for sexually transmitted infections (stis) and human immunodeficiency virus (hiv). they have risky sexual behaviors but low risk perception. | 2006 | 17179617 |
| [serologic examination for childhood herpes simplex virus infection]. | this study was designed to investigate the value of serologic examination in the diagnosis of childhood herpes simplex virus (hsv) infection. | 2006 | 17178039 |
| increased prevalence of varicella zoster virus dna in cerebrospinal fluid from patients with multiple sclerosis. | in order to investigate the possible involvement of viruses in multiple sclerosis (ms), the study evaluated the presence of viral genomic sequences in cerebrospinal fluid (csf), as markers of viral replication within the central nervous system (cns). a total of 85 csf samples were collected from 38 ms patients, 28 patients with other neurological diseases and 19 subjects without neurological diseases. using nested-pcr, the investigation focused on the presence of human herpes virus dna, includin ... | 2007 | 17177306 |
| human herpesvirus 8 and human herpesvirus 2 infections in prison population. | incarcerated persons have high rates of infectious diseases. few data on the prevalence of sexually transmitted diseases in prisoners are available. this multi-center cross-sectional study enrolled 973 inmates from eight italian prisons. demographic and behavioral data were collected using an anonymous standardized questionnaire and antibodies to hiv, hcv, hbv, hsv-2, and hhv-8 were detected in a blood sample obtained from each person at the time of the enrollment in the study. two hundred and t ... | 2007 | 17177300 |
| appropriate use of polymerase chain reaction for detection of herpes simplex virus 2 in cerebrospinal fluid of patients at an inner-city hospital. | polymerase chain reaction (pcr) tests that detect herpes simplex virus (hsv) dna in cerebrospinal fluid (csf) are increasingly used to diagnose central nervous system (cns) infections caused by hsv. to determine proper utilization of this test at an inner-city hospital, we performed a case-control study of adult patients, with hsv detected in csf by pcr. retrospective review of characteristics of adult patients hospitalized between 1997 and 2000 with csf positive for hsv was done and compared to ... | 2007 | 17175126 |
| factors that affect in vitro measurement of the susceptibility of herpes simplex virus to nucleoside analogues. | to identify factors that contribute to variability of hsv antiviral susceptibility breakpoints. | 2007 | 17169605 |
| cidofovir is effective against caprine herpesvirus 1 infection in goats. | caprine herpesvirus 1 (cphv-1) is a virus able to cause genital infection leading to vulvovaginitis or balanoposthitis in adult goats. cphv-1 shares several biological similarities with herpes simplex type 2 (hsv-2) infection in man, such as genital tropism, type and site of typical lesions and it might provide an animal model for studies on antiviral drugs for hsv-2 infection in man. in this view the efficacy of cidofovir (cdv) drug was tested in six goats intravaginally infected with ba.1 stra ... | 2007 | 17161474 |
| herpes simplex virus-type 2 infectivity and agents that block gap junctional intercellular communication. | in rat liver epithelial (wb) cells, the protein kinase c inhibitor h7 blocked gap junctional intercellular communication (gjic) and reduced virus infectivity. octanol, 18-beta-glycyrrhetinic acid, and staurosporine, agents that reduce gjic, had no effect upon virus infectivity. previous studies demonstrated that herpes simplex virus-type 2 (hsv-2) infection was accompanied by attenuated gjic. of agents tested, only h7 reduced plaque forming unit (pfu) ability in a dose-dependent manner with 100% ... | 2007 | 17157406 |
| herpes simplex virus type 2-mediated disease is reduced in mice lacking rnase l. | rnase l helps mediate the antiviral state induced by type i interferons (ifnalphabeta). although herpes simplex virus (hsv) encodes inhibitors of the ifnalphabeta-induced antiviral response, the ifnalphabeta system serves the body as a first line of defense against hsv. we investigated whether rnase l limits hsv-2 replication and virulence. rnasel(-/-) and wild-type c57bl/6 mice were infected intravaginally with hsv-2 strain 333. although initial replication in the genital epithelium was similar ... | 2007 | 17157346 |
| [reversible posterior leukoencephalopathy syndrome in hashimoto's encephalopathy: a case report]. | a 45-year-old woman with breast cancer was admitted to our hospital because of several episodes of disturbed consciousness and generalized convulsions. while these symptoms resolved quickly, dysphagia and bilateral blepharoptosis persisted. neurological findings were improved by steroid therapy. mri on the first hospital day showed t2/flair high intensity lesions in both occipital lobes, but these lesions diminished on the 8th day, indicating reversible posterior leukoencephalopathy syndrome. a ... | 2006 | 17154034 |
| no evidence of relation between maternal exposure to herpes simplex virus type 2 and risk of schizophrenia? | the authors examined whether maternal exposure to herpes virus type 2 is associated with risk for adult schizophrenia. | 2006 | 17151171 |
| herpes simplex virus type 2 (hsv-2) establishes latent infection in a different population of ganglionic neurons than hsv-1: role of latency-associated transcripts. | herpes simplex virus type 1 (hsv-1) and hsv-2 cause very similar acute infections but differ in their abilities to reactivate from trigeminal and dorsal root ganglia. to investigate differences in patterns of viral infection, we colabeled murine sensory ganglia for evidence of hsv infection and for the sensory neuron marker a5 or kh10. during acute infection, 7 to 10% of hsv-1 or hsv-2 antigen-positive neurons were a5 positive and 13 to 16% were kh10 positive, suggesting that both viruses reach ... | 2007 | 17151134 |
| genital herpes. | 2006 | 17151051 | |
| antibodies against six human herpesviruses in relation to seven cancers in black south africans: a case control study. | infections with certain human herpesviruses have been established as risk factors for some cancer types. for example, epstein-barr virus is considered a cause of burkitt's lymphoma and other immunosuppression related lymphomas, hodgkin lymphoma, and nasopharyngeal cancer. several other human herpesviruses have been linked to cancers but the totality of evidence is inconclusive. | 2006 | 17150131 |
| hormonal contraception and the risk of hiv acquisition. | combined oral contraceptives (coc) and depot-medroxyprogesterone acetate (dmpa) are among the most widely used family planning methods; their effect on hiv acquisition is not known. | 2007 | 17148972 |
| evidence for sexual transmission of genital herpes in children. | genital herpes in a prepubertal child presents a child protection clinician with a difficult problem: how likely is it that transmission occurred as a consequence of sexual abuse? published guidelines on the management of sexually transmitted infections in children provide varying recommendations and refer to a limited literature. | 2007 | 17148543 |
| herpes simplex virus infections in preterm infants. | neonatal herpes simplex virus infections cause significant neonatal mortality and morbidity, but the course and prognosis in preterm infants is not well documented. we performed a retrospective review of herpes simplex virus infections at out institution within the first 30 days after birth in infants who were born at <37 weeks to help better define the symptoms and signs of herpes simplex virus infections in preterm infants and to assist in prognosis. | 2006 | 17142491 |
| detection of herpes simplex virus type 1 in addition to epstein-bar virus in tonsils using a new multiplex polymerase chain reaction assay. | hsv-1, hsv-2, cmv, ebv, which are the members of the herpes virus family colonize and establish latent infection in human. although ebv is a well known virus most involved in recurrent bouts of acute tonsillitis, the role and possibility of hsv-1, hsv-2, and cmv for establishing infection in tonsils are not clear. the purpose of this study is to verify whether the tonsils might harbor the hsv-1, hsv-2, and cmv, in addition to ebv, in chronically hyperplastic nasopharyngeal lymphoid tissue. to ac ... | 2007 | 17141448 |
| an early event in the herpes simplex virus type-2 replication cycle is sufficient to induce chlamydia trachomatis persistence. | epidemiological studies have demonstrated that co-infections of herpes simplex virus type 2 (hsv-2) and chlamydia trachomatis occur in vivo. data from a tissue culture model of c. trachomatis/hsv-2 co-infection indicate that viral co-infection stimulates the formation of persistent chlamydiae. transmission electron microscopic (tem) analyses demonstrated that in both hela and hec-1b cells, co-infection caused developing chlamydiae to exhibit swollen, aberrantly shaped reticulate bodies (rbs), ch ... | 2007 | 17140408 |
| impact of suppressive herpes therapy on genital hiv-1 rna among women taking antiretroviral therapy: a randomized controlled trial. | to demonstrate a causal relationship between herpes simplex virus 2 (hsv-2) and increased genital hiv-1-rna shedding in women on haart. | 2006 | 17117016 |
| primary herpes simplex virus type-2 infection as a cause of liver failure after liver transplantation. | we report a case of fatal primary herpes simplex virus type-2 (hsv-2) infection following liver transplantation, which manifested with fever and liver failure in the absence of muco-cutaneous disease. the infection was characterized by high levels of hsv dna in blood and the patient's inability to mount hsv-specific t-cell responses while showing preserved t-cell responses against cytomegalovirus. the donor was hsv-1 immunoglobulin g (igg) seronegative and hsv-2 igg seropositive, whereas the rec ... | 2006 | 17116138 |
| cutting edge: plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ. | dendritic cells (dcs) are powerful apcs capable of activating naive lymphocytes. of the dc subfamilies, plasmacytoid dcs (pdcs) are unique in that they secrete high levels of type i ifns in response to viruses but their role in inducing adaptive immunity remains divisive. in this study, we examined the importance of pdcs and their ability to recognize a virus through tlr9 in immunity against genital hsv-2 infection. we show that a low number of pdcs survey the vaginal mucosa at steady state. upo ... | 2006 | 17114418 |
| the in vitro activity of geraniin and 1,3,4,6-tetra-o-galloyl-beta-d-glucose isolated from phyllanthus urinaria against herpes simplex virus type 1 and type 2 infection. | phyllanthus urinaria linnea (euphorbiaceae) is a widely used traditional medicinal plant by oriental countries and has been reported to possess various biological activities. previously, the acetone extract from phyllanthus urinaria was found to inhibit herpes simplex virus (hsv) infection. in this study, geraniin and 1,3,4,6-tetra-o-galloyl-beta-d-glucose (1346togdg), both of which were isolated from the acetone extract of phyllanthus urinaria, were examined for their activity against hsv-1 and ... | 2007 | 17113739 |
| bacterial vaginosis in women of low socioeconomic status living in slum areas in chennai, india. | bacterial vaginosis (bv) is a common cause of vaginitis among women of childbearing age. this study was performed to investigate the prevalence of bv and its association with sexually transmitted infections among 487 women of low socioeconomic status. blood, vaginal and endocervical swabs were tested for hiv, herpes simplex virus-2 (hsv-2), treponema pallidum, bv, chlamydia trachomatis, neisseria gonorrhoea and trichomonas vaginalis. of the women screened for bv, 120 (25, 95% ci 20.8-28.4) were ... | 2006 | 17112444 |
| seroprevalence of herpes simplex virus-1 and -2 in attendees of a sexually transmitted infection clinic in singapore. | we studied the seroprevalance of hsv (herpes simplex virus)-1 and hsv-2 in outpatient attendees of a sexually transmitted infection (sti) clinic in singapore and examined their knowledge and attitudes towards hsv infection. | 2006 | 17112439 |
| herpes simplex virus type 2: epidemiology and management options in developing countries. | genital herpes simplex virus type 2 (hsv2) is highly prevalent worldwide and an increasingly important cause of genital ulcer disease (gud). continued hsv2 transmission is facilitated by the large number of undiagnosed cases, the frequency of atypical disease and the occurrence of asymptomatic shedding. the lack of easy, affordable diagnostic methods and specific antiviral treatment in countries with low and middle income is of great concern, given the ability of gud to enhance hiv transmission ... | 2007 | 17098770 |
| recurrent aseptic meningitis associated with herpes simplex virus type 2. | 2006 | 17098119 | |
| early diffusion-weighted magnetic resonance imaging findings in neonatal herpes encephalitis. | neonatal herpes encephalitis is usually caused by herpes simplex virus type 2 and results in significant morbidity and mortality. imaging diagnosis with ultrasound, computed tomography scan and conventional magnetic resonance imaging may be normal in the early course of the disease. in this case diffusion-weighted magnetic resonance imaging detected the disease process earlier and better than the conventional t2-weighted or fluid-attenuated inversion recovery imaging sequences. the use of diffus ... | 2006 | 17096722 |
| a recombinant multivalent combination vaccine protects against chlamydia and genital herpes. | chlamydia trachomatis and herpes simplex virus type 2 (hsv-2) genital infections pose a considerable public health challenge worldwide. considering the high incidence of coinfections by the two pathogens, a combination vaccine that can be administered as a single regimen would be highly desirable. recombinant vibrio cholerae ghosts (rvcg) offer an attractive approach for the induction of humoral and cellular immune responses against human and animal pathogens. in this study, we evaluated a bival ... | 2007 | 17094789 |
| role of ifn-alpha/beta signaling in the prevention of genital herpes virus type 2 infection. | this study has shown that ifn-alpha/beta signaling is crucial for combating primary herpes simplex virus type 2 (hsv-2) infection and for responding to immunotherapy using ligands to tlr3, 7 and 9, but not for vaccine-induced immunity. both genital viral replication and the disease progression were enhanced in hsv-2-infected mice lacking the ifn-alpha/beta receptor (ifn-alpha/betar-/-). ifn-alpha/betar-/- mice were, however, able to mount a normal hsv-2-specific th1 response and acquired sterili ... | 2007 | 17092567 |
| antiviral effect of aqueous extracts from species of the lamiaceae family against herpes simplex virus type 1 and type 2 in vitro. | aqueous extracts from species of the lamiaceae family were examined for their antiviral activity against herpes simplex virus (hsv). extracts from lemon balm (melissa officinalis), peppermint (mentha x piperita), prunella (prunella vulgaris), rosemary (rosmarinus officinalis), sage (salvia officinalis) and thyme (thymus vulgaris) were screened. their inhibitory activity against herpes simplex virus type 1 (hsv-1), type 2 (hsv-2) and an acyclovir-resistant strain of hsv-1 (acv (res)) was tested i ... | 2006 | 17091431 |
| immunological profiles of patients with chronic myeloid leukaemia. i. state before the start of treatment. | in view of the increasing interest in the immunotherapy of cml it seems highly desirable to broaden the present knowledge on the immune reactivity of cml patients. a group of 24 patients and 24 healthy controls were studied for the total of 15 immunological parameters, including the prevalence of antibodies against human herpesviruses and papillomaviruses. to clearly discriminate between changes associated with the disease and those induced by the therapy, all patients were enrolled prior to the ... | 2006 | 17089915 |
| [genital herpes]. | genital herpes simplex virus (hsv-1 and hsv-2) infection is an ulcerative, lifelong, recurring sexually transmitted disease of increasing epidemiologic worldwide importance. transmission occurs by close skin contact, usually during asymptomatic virus shedding. the virus persists in the dorsal root ganglion where it is not accessible to the host's immune system. the most important risk factor is a person's number of lifetime sex partners. the more extensive first-episode infection is followed by ... | 2006 | 17089142 |
| seroprevalence of herpes simplex virus type 2 in multiple sclerosis. | it has been proposed that multiple sclerosis (ms) might be a sexually transmitted disorder. there is evidence that seropositivity to herpes simplex virus type 2 (hsv-2) correlates well with the number of sexual partners. accordingly, a raised overall hsv-2 seroprevalence in ms would lend support to this theory. | 2006 | 17083334 |
| beseiged. | 2006 | 17071158 | |
| apoptosis and antigen receptor function in t and b cells following exposure to herpes simplex virus. | t cells are an essential component of the immune response against herpes simplex virus (hsv) infection. we previously reported that incubation of t cells with hsv-infected fibroblasts inhibits subsequent t cell antigen receptor signal transduction. in the current study, we found that incubation of t cells with hsv-infected fibroblasts also leads to apoptosis in exposed t cells. apoptosis was observed in jurkat cells, a t cell leukemia line, and also in cd4(+) cells isolated from human peripheral ... | 2007 | 17067652 |
| 3'-carbon-substituted pyrimidine nucleosides having a 2',3'-dideoxy and 2',3'-didehydro-2',3'-dideoxy structure: synthesis and antiviral evaluation. | the bis(tributylstannyl) derivative of 2',3'-didehydro-2',3'-dideoxyuridine (d4u) underwent an anionic 5'-o-->3'-c stannyl migration to yield the 3'-tributylstannyl-d4u. this compound, with its vinylstannane structure, allowed ready access to the preparation of 3'-carbon-substituted analogues through the stille reaction. a conventional transformation of the uracil moiety of these d4u analogues led to the corresponding 2',3'-didehydro-2',3'-dideoxycytidine (d4c) counterparts. some 2',3'-dideoxycy ... | 2006 | 17066900 |
| suppressive therapy with valacyclovir in early genital herpes: a pilot study of clinical efficacy and herpes-related quality of life. | suppressive therapy has not been studied during the first year after acquisition of genital herpes, the time of maximum frequency of reactivation, potential for transmission, and impact on quality of life. | 2007 | 17065847 |
| early resolution of herpes simplex virus type 2 infection of the murine genital tract involves stimulation of genital parenchymal cells by gamma interferon. | early clearance of a thymidine kinase-deficient strain of herpes simplex virus type 2 from the female genital tract required t-cell-produced gamma interferon (ifn-gamma). transfer of activated cd8+ t cells to irradiated c57bl/6 mice resulted in rapid virus clearance, but clearance was greatly delayed in recipients deficient in the ifn-gamma receptor (ifn-gammar). early virus clearance was demonstrated in radiation chimeras in which ifn-gammar expression was limited to parenchymal cells, but reso ... | 2007 | 17065206 |
| hsv-2 antibodies in female sex workers in vietnam. | little information is available on the prevalence of herpes simplex type-2 (hsv-2) antibodies among groups at potential high risk of hiv in asia. this study was carried out to determine the prevalence of hsv-2 antibodies and correlates of hsv-2 infection in female sex workers (fsws) in border provinces of vietnam. nine hundred and four fsws in five border provinces of vietnam were interviewed about selected sociodemographic and behavioural characteristics, and information about partners by a sta ... | 2006 | 17062180 |
| seroprevalence of herpes simplex virus type 1 and type 2 in turkey. | herpes simplex virus (hsv) infections are among the most common infectious diseases in humans. the prevalence of herpes simplex viruses type 1 (hsv-1) and type 2 (hsv-2) varies widely across the world. hsv-2 infection is the primary cause of genital herpes. it is highly prevalent in human populations in many parts of the world, and is the most common cause of genital ulcer disease worldwide. in spite of the large prevalence and growing incidence of herpes simplex infection (hsv-1 and hsv-2), rel ... | 2006 | 17062037 |
| comparison of two methods of pcr followed by enzymatic restriction digestion for detection and typing of herpes simplex viruses isolated from patients with mucocutaneous or cutaneous lesions. | a multitude of different polymerase chain reactions (pcrs) have been described for detection and typing of herpes simplex virus (hsv). this paper compares two pcrs coupled to enzymatic restriction (pcr/rflp) to detect and type hsv. a primers set was designed to amplify a hsv dna fragment from ul30 and ul 15 genes. typing was done by restriction of the ul30 and ul15 amplicons with ava ii and hpa ii enzymes, respectively. this strategy was tested with two reference strains (hsv-1 mcintyre, and hsv ... | 2005 | 17061531 |
| association between hsv-2 and hiv-1 viral load in semen, cervico-vaginal secretions and genital ulcers of thai men and women. | we studied the association between herpes simplex virus type-2 (hsv-2) and hiv-1 viralload in plasma, semen, cervico-vaginal secretions and genital ulcers. forty-seven (68%) men and 57 (80%) women were hsv-2 antibody positive, of whom 12 (26%, 95% confidence interval [ci] 20, 32) and five (8%, 95% ci 4, 12), respectively, had hsv-2 genital shedding detected by polymerase chain reaction. the mean hiv-1 seminal and cervico-vaginal viral loads did not differ significantly according to the presence ... | 2006 | 17059638 |
| famciclovir for the treatment of recurrent genital herpes: a clinical and pharmacological perspective. | herpes simplex virus is one of the most common causes of genital ulcer disease worldwide. herpes simplex virus-2 is the more common cause of genital herpes, a chronic infection that is characterised by periodic reactivation, with the capacity to produce recurrent symptomatic disease in the host (e.g., vesicular eruption), as well as intermittent asymptomatic shedding. relapsing episodes may be physically and psychologically distressing. shedding accounts for the majority of cases of transmission ... | 2006 | 17059383 |
| association of herpes simplex virus type 2 infection and syphilis with human immunodeficiency virus infection among men who have sex with men in peru. | we evaluated associations between human immunodeficiency virus (hiv) infection, herpes simplex virus type 2 (hsv-2) infection, and syphilis among men who have sex with men (msm) in peru. | 2006 | 17054077 |
| comparison of different polymerase chain reaction methods for detection of herpes simplex virus types 1 and 2 encephalitis. | 2006 | 17047902 | |
| the hsv-2 protein icp10pk prevents neuronal apoptosis and loss of function in an in vivo model of neurodegeneration associated with glutamate excitotoxicity. | excessive glutamate receptor activation results in neuronal death, a process known as excitotoxicity. intrastriatal injection of n-methyl-d-aspartate (nmda) is a model of excitotoxicity. we used this model to examine whether excitotoxic injury is inhibited by the anti-apoptotic herpes simplex virus type 2 (hsv-2) protein, icp10pk, delivered by the replication incompetent hsv-2 vector, deltarr. intrastriatal deltarr administration (2500 plaque forming units) was nontoxic and did not induce microg ... | 2007 | 17046754 |