Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| phase i study of a herpes simplex virus type 2 (hsv-2) dna vaccine administered to healthy, hsv-2-seronegative adults by a needle-free injection system. | we conducted a double-blind, vehicle-controlled, dose escalation safety and immunogenicity trial of a candidate herpes simplex virus type 2 (hsv-2) surface glycoprotein d2 (gd2) dna vaccine administered by use of a needle-free device. sixty-two healthy adults were randomized using a 4:1 vaccine-to-placebo ratio. half of the participants were hsv-1 seronegative, and all were hsv-2 seronegative. vaccine doses included 100 microg, 300 microg, 1,000 microg or 3,000 microg of a plasmid expressing the ... | 2008 | 18784341 |
| progressive hypertrophic genital herpes in an hiv-infected woman despite immune recovery on antiretroviral therapy. | most hiv-infected individuals are coinfected by herpes simplex virus type 2 (hsv-2). hsv-2 reactivates more frequently in hiv-coinfected individuals with advanced immunosuppression, and may have very unusual clinical presentations, including hypertrophic genital lesions. we report the case of a progressive, hypertrophic hsv-2 lesion in an hiv-coinfected woman, despite near-complete immune restoration on antiretroviral therapy for up to three years. in this case, there was prompt response to topi ... | 2008 | 18784844 |
| detection of human herpesvirus dna in kikuchi-fujimoto disease and reactive lymphoid hyperplasia. | kikuchi-fujimoto disease (kfd), or histiocytic necrotizing lymphadenitis, is a subacute inflammatory disorder most often seen in young women with clinicopathologic features suggestive of an infectious etiology. the most commonly suspected infectious agents in kfd are the human herpesviruses ebv, hhv6, hhv7 and hhv8. in order to identify herpesviruses in kfd, we have compared the frequency of detection of herpesvirus dna with a recently developed real time pcr method, eber in situ hybridization, ... | 2008 | 18787614 |
| first synthesis and anti-hiv evaluation of 4'-methyl-cyclopentanyl 9-deazaadenosine. | the first synthesis of a 4'-methylated carbocyclic c-nucleoside 16 was achieved via the mesylate intermediate 10, which was prepared using ring-closing metathesis and s(n)2 alkylation from acetol 5. when antiviral evaluation of synthesized compound 16 was performed against various viruses such as hiv, hsv-1, hsv-2, and hcmv, it showed moderate anti-hiv activity in mt-4 cell line (ec(50) = 14.7 micromol). | 2008 | 18788044 |
| 2/4-substituted-9-fluorenones and their o-glucosides as potential immunomodulators and anti-herpes simplex virus-2 agents. part 5. | in pursuing a research on the antiviral and immunomodulatory activity of tilorone congeners, two new series of compounds were prepared and pharmacologically explored: 9-fluorenone carboxyhydroxyesters, indicated as ag, and 9-fluorenone carboxyhydroxamides, indicated as mg. two of them, ag17 and mg3, were used as sugar acceptors in the transglycosylation reactions performed by alpha- and beta-glucosidases extracted from the marine mollusc aplysia fasciata providing different alpha- and beta-, mon ... | 2008 | 18789558 |
| dendritic cells mediate herpes simplex virus infection and transmission through the c-type lectin dc-sign. | dendritic cells (dcs) are essential for the induction of specific immune responses against invading pathogens. herpes simplex virus (hsv) is a common human pathogen that causes painful but mild infections of the skin and mucosa, and which results in latency and recurrent infections. of the two hsv subtypes described, hsv-1 causes mainly oral-facial lesions, whilst hsv-2 is associated with genital herpes. dcs are involved in hsv-induced immune suppression, but little is known about the molecular ... | 2008 | 18796707 |
| population-level effect of hsv-2 therapy on the incidence of hiv in sub-saharan africa. | herpes simplex virus type 2 (hsv-2) infection increases acquisition and transmission of hiv, but the results of trials measuring the impact of hsv-2 therapy on hiv genital shedding and hiv acquisition are mixed, and the potential impact of hsv-2 therapy on the incidence of hiv at the population level is unknown. | 2008 | 18799486 |
| asymptomatic human cd4+ cytotoxic t-cell epitopes identified from herpes simplex virus glycoprotein b. | the identification of "asymptomatic" (i.e., protective) epitopes recognized by t cells from herpes simplex virus (hsv)-seropositive healthy individuals is a prerequisite for an effective vaccine. using the pepscan epitope mapping strategy, a library of 179 potential peptide epitopes (15-mers overlapping by 10 amino acids) was identified from hsv type 1 (hsv-1) glycoprotein b (gb), an antigen that induces protective immunity in both animal models and humans. eighteen groups (g1 to g18) of 10 adja ... | 2008 | 18799581 |
| antibodies to cytomegalovirus and herpes simplex virus 1 associated with cognitive function in schizophrenia. | cognitive impairment in the form of decreased working memory and executive functions has been recognized as a key deficit in schizophrenia. neurotropic viruses have been associated with focal gray matter deficits in patients with schizophrenia. we evaluated whether such agents alter cognitive function in schizophrenia. | 2008 | 18801645 |
| intranasal and subcutaneous immunization under the effect of estradiol leads to better protection against genital hsv-2 challenge compared to progesterone. | this study examined the effect of hormonal environment on intranasal and subcutaneous routes of immunization in a genital herpes infection model. ovariectomized mice were treated with estradiol (e(2)), progesterone (p(4)) or placebo hormone pellets and immunized intranasally (i.n.) or subcutaneously (s.c.) with attenuated hsv-2. immunized mice were subsequently challenged, intravaginally, with wild-type hsv-2. mice immunized under the influence of e(2) showed higher survival rates, reduced patho ... | 2008 | 18804503 |
| herpes complex. | 2008 | 18809697 | |
| extensive atypical genital herpes simplex type 2 infection as an initial manifestation of acquired immune deficiency syndrome. | we present a case of an ulcerative lesion of the genitalia starting one year before in a 33-year-old man. histopathologic examination revealed herpes virus infection, which suggested the existence of cell-mediated immunodeficiency. human immunodeficiency virus (hiv) infection was confirmed by elisa and western blot test. the patient was treated with intravenous acyclovir, which led to complete remission. we underline the importance of early detecting and diagnosing patients with similar clinical ... | 2008 | 18812065 |
| co-expression of hsv2 and chlamydia trachomatis in hpv-positive cervical cancer and cervical intraepithelial neoplasia lesions is associated with aberrations in key intracellular pathways. | oncogenic human papillomaviruses (hpvs) are the etiological agents of cervical cancer. different cofactors might be needed for malignant transformation, but they still remain elusive. | 2008 | 18812695 |
| reversible progressive cognitive decline due to herpes simplex type 2 encephalitis with normal mr imaging. | 2008 | 18821048 | |
| [investigation of herpes simplex virus in viral meningoencephalitis suspected cases using molecular and serological methods]. | herpes simplex virus (hsv) meningoencephalitis has a high mortality rate if proper antiviral therapy is not applied. thus rapid diagnosis is of peculiar importance in such cases. in this study we aimed to evaluate the use of polymerase chain reaction (pcr) and detection of intrathecally synthesized antibodies by serological methods in viral meningoencephalitis suspected cases to determine hsv as the causative agent. seventeen cases with cerebrospinal fluid (csf) samples with microscopical and bi ... | 2008 | 18822885 |
| sexually transmitted infections among brothel-based sex workers in tel-aviv area, israel: high prevalence of pharyngeal gonorrhoea. | sex workers play a major role in spreading sexually transmitted infections (stis). we studied the prevalence rates and risk factors for stis among 300 brothel-based sex workers in tel-aviv. throat swabs were cultured for neisseria gonorrhoeae, urine samples were tested by polymerase chain reaction (pcr) for chlamydia trachomatis and n. gonorrhoeae, and sera were tested for syphilis, human immunodeficiency virus (hiv) and type 2 herpes simplex virus (hsv) antibodies. n. gonorrhoeae was cultured f ... | 2008 | 18824615 |
| herpes simplex virus type 2 infection among commercial sex workers in kunming, yunnan province, china. | a cross-sectional survey was conducted to determine the sociodemographic correlates of herpes simplex virus type 2 (hsv-2) infection among male and female commercial sex workers in kunming, yunnan province of china. hsv-2 prevalence was 33.0%, human immunodeficiency virus (hiv) infection was 2.4% and hepatitis c virus (hcv) infection was 6.8%. subjects who were positive for hsv-2 had a significantly higher prevalence of hiv infection (5.5% versus 0.9%, p = 0.002; odds ratio [or]: 6.4, p = 0.006) ... | 2008 | 18824623 |
| world summit of antivirals--bit life sciences' first annual summit. combating severe viral infections. | 2008 | 18828069 | |
| mollaret's meningitis. | pierre mollaret is mainly known for his contributions to infectious diseases and their prevention. he also described benign, recurrent endothelio-leukocytic meningitis in three patients who had short-lived recurrent attacks of fever, headache and vomiting caused by sterile meningitis, with 'fantomes cellulaires' (cell ghosts) in the cerebrospinal fluid. identical symptoms are caused by herpes simplex virus-2 and other viruses. the term mollaret's meningitis should be restricted to idiopathic rec ... | 2008 | 18832846 |
| adherence to biomedical hiv prevention methods: considerations drawn from hiv treatment adherence research. | biomedical approaches to hiv prevention (eg, microbicides, antiretroviral preexposure prophylaxis) are undergoing clinical trials to test their efficacy. one key consideration emerging from completed trials is the critical role of adherence to the investigational product. suboptimal product adherence may compromise clinical trial results and ultimately undermine the effectiveness of biomedical prevention methods in any future real-world use. efforts to strengthen biomedical hiv prevention produc ... | 2008 | 18838058 |
| evaluation of a new point-of-care serologic assay for herpes simplex virus type 2 infection. | herpes simplex virus type 2 infection is one of the most common sexually transmitted diseases. because presentation is often atypical or subclinical, serologic testing is necessary for diagnosis, treatment, and counseling. in an urban clinic that specializes in the treatment of sexually transmitted disease, a new point-of-care rapid serologic test was compared with enzyme-linked immunosorbent assay or western blot for the detection of herpes simplex virus type 2. with use of an enzyme-linked imm ... | 2008 | 18840082 |
| herpes simplex virus downregulates secretory leukocyte protease inhibitor: a novel immune evasion mechanism. | secretory leukocyte protease inhibitor (slpi), an anti-inflammatory mediator of mucosal immunity, inhibits human immunodeficiency virus (hiv) and herpes simplex virus (hsv) in cell culture. epidemiological studies demonstrate that higher concentrations of slpi in mucosal secretions are associated with a reduced risk of hiv transmission. the current studies were designed to test the hypothesis that hsv triggers a loss of slpi to evade innate immunity and that this response may contribute to the i ... | 2008 | 18667508 |
| suppressive acyclovir therapy reduces hiv cervicovaginal shedding in hiv- and hsv-2-infected women, chiang rai, thailand. | herpes simplex virus type 2 infection is important in the hiv epidemic and may contribute to increased hiv transmission. we evaluated the effect of suppressive acyclovir therapy on cervicovaginal hiv-1 shedding. | 2008 | 18667923 |
| anti-herpes effect of hemocyanin derived from the mollusk rapana thomasiana. | the cytotoxicity and the antivirus activity of native hemocyanin, rth, derived from the bulgarian marine mollusk rapana thomasiana and its structural isoform, rth2, against hsv replication was evaluated on three hsv strains--two wt strains, tm (hsv 1) and bja (hsv 2), and one acvr mutant with tk gene mutation, dd (hsv 2). the experiments were performed on continuous rd 64 cells and three hsv 1 and hsv 2 strains were used, two mutants sensitive to acyclovir and one resistant mutant. both compound ... | 2008 | 18669031 |
| hsv-2 suppression and the incidence of hiv. | 2008 | 18669436 | |
| herpes simplex virus 2 serostatus and viral loads of hiv-1 in blood and semen as risk factors for hiv transmission among men who have sex with men. | human immunodeficiency virus type 1 blood plasma viral load is correlated with the sexual transmission of hiv, although transmission from men involves virus from semen instead of blood. we quantified hiv-1 rna in the blood and semen of men who did or did not transmit hiv to their sex partners. we compared the relationships of hiv-1 transmission risk with blood plasma viral load, seminal plasma viral load, herpes simplex virus 2 serostatus and other factors. | 2008 | 18670228 |
| risk factors for recent hiv infection in uganda. | studies of factors associated with acquiring human immunodeficiency virus (hiv) are often based on prevalence data that might not reflect recent infections. | 2008 | 18677026 |
| an acutely and latently expressed herpes simplex virus 2 viral microrna inhibits expression of icp34.5, a viral neurovirulence factor. | latency-associated transcript (lat) sequences regulate herpes simplex virus (hsv) latency and reactivation from sensory neurons. we found a hsv-2 lat-related microrna (mirna) designated mir-i in transfected and infected cells in vitro and in acutely and latently infected ganglia of guinea pigs in vivo. mir-i is also expressed in human sacral dorsal root ganglia latently infected with hsv-2. mir-i is expressed under the lat promoter in vivo in infected sensory ganglia. we also predicted and ident ... | 2008 | 18678906 |
| herpes simplex virus load in bronchoalveolar lavage fluid is related to poor outcome in critically ill patients. | to evaluate the relationship between the hsv-1 and -2 loads in bal fluid (balf) and clinical outcome. | 2008 | 18679655 |
| a high-sensitivity method for detection and measurement of hmgb1 protein concentration by high-affinity binding to dna hemicatenanes. | protein hmgb1, an abundant nuclear non-histone protein that interacts with dna and has an architectural function in chromatin, was strikingly shown some years ago to also possess an extracellular function as an alarmin and a mediator of inflammation. this extracellular function has since been actively studied, both from a fundamental point of view and in relation to the involvement of hmgb1 in inflammatory diseases. a prerequisite for such studies is the ability to detect hmgb1 in blood or other ... | 2008 | 18682735 |
| [human infection with simian herpes b virus in africa]. | simian herpes b virus or cercopithecine herpesvirus 1 (cehv-1) is enzootic (80% to 100%) in asian monkeys of the genus macaca but is also present in other monkey species. this virus, discovered in 1933, is closely related to human herpesvirus 1 and human herpesvirus 2, responsible respectively for labial and genital herpes. cehv-1 infection is generally asymptomatic or mild in monkeys but in humans it may lead to fulminant encephalomyelitis that has an 80% lethality rate without treatment. infec ... | 2008 | 18684683 |
| herpes simplex virus type 2-induced mortality following genital infection is blocked by anti-tumor necrosis factor alpha antibody in cxcl10-deficient mice. | the role of tumor necrosis factor alpha (tnf-alpha) was evaluated for cxcl10-deficient (cxcl10(-/-)) mice which succumbed to genital herpes simplex virus type 2 (hsv-2) infection and possessed elevated levels of virus and tnf-alpha but not other cytokines in the central nervous system (cns) and vaginal tissue within the first 7 days following virus exposure. anti-tnf-alpha but not control antibody treatment offsets the elevated mortality rate of cxcl10(-/-) mice, despite increased cns viral tite ... | 2008 | 18684827 |
| a randomised placebo-controlled trial to explore the effect of suppressive therapy with acyclovir on genital shedding of hiv-1 and herpes simplex virus type 2 among zimbabwean sex workers. | to determine the effect of daily acyclovir on genital shedding of hiv-1 and herpes simplex virus type 2 (hsv-2) in a randomised placebo-controlled trial among rural zimbabwean sex workers. | 2008 | 18684855 |
| reassessing the hypothesis on sti control for hiv prevention. | 2008 | 18572064 | |
| effect of aciclovir on hiv-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial. | across many observational studies, herpes simplex virus type 2 (hsv-2) infection is associated with two-fold to three-fold increased risk for hiv-1 infection. we investigated whether hsv-2 suppression with aciclovir would reduce the risk of hiv-1 acquisition. | 2008 | 18572080 |
| anti-herpetic activity of a sulfated xylomannan from scinaia hatei. | many viruses display affinity for cell surface heparan sulfate proteoglycans with biological relevance in virus entry. this raises the possibility of the application of sulfated polysaccharides in antiviral therapy. in this study we have analyzed polysaccharide fractions isolated from scinaia hatei. the crude water extract (shwe) as well as one fraction (f1) obtained by size exclusion chromatography had potent anti-hsv activity. their inhibitory concentration 50% (ic50) values ranging from 0.5 t ... | 2008 | 18572208 |
| protein arrays based on biotin-streptavidin system for the simultaneous detection of torch infections. | in this paper, we developed a protein array based on biotin-streptavidin system (pabs) used in the identification of igm antibodies against torch antigens, including toxoplasma gondii (tox), rubella virus (ruv), cytomegalovirus (cmv) and herpes simplex virus types ii (hsv-2) antigens. the detection signal intensities and sensitivities between the pabs and the direct labeling array system (dlas) were compared. the linear ranges of detectable igm antibodies in pabs were 0.485-1000 microg/ml, which ... | 2008 | 18572639 |
| effect of an immune enhancer, gpi-0100, on vaccination with live attenuated herpes simplex virus (hsv) type 2 or glycoprotein d on genital hsv-2 infections of guinea pigs. | these studies were performed to determine the effect of ad-472, an attenuated human herpes simplex virus (hsv) type 2 or hsv-2 glycoprotein d (gd) when combined with an adjuvant, gpi-0100, a semi-synthetic quillaja saponin analog in a genital hsv-2 infection in guinea pigs. while animals immunized with either vaccine had reduced clinical disease, gpi-0100 only improved the efficacy of gd and did not affect the efficacy of the live vaccine. neither vaccine had any therapeutic effect if administer ... | 2008 | 18573279 |
| anti-herpes simplex virus (hsv-1) activity of oxyresveratrol derived from thai medicinal plant: mechanism of action and therapeutic efficacy on cutaneous hsv-1 infection in mice. | oxyresveratrol, a major compound purified from artocarpus lakoocha, a thai traditional medicinal plant, was evaluated for its mechanism of action and therapeutic efficacy on cutaneous herpes simplex virus (hsv) infection in mice. the inhibitory concentrations for 50% hsv-1 plaque formation of oxyresveratrol, three clinical isolates, thymidine kinase (tk)-deficient and phosphonoacetic acid (paa)-resistant hsv-1 were 19.8, 23.3, 23.5, 24.8, 25.5 and 21.7microg/ml, respectively. oxyresveratrol exhi ... | 2008 | 18565600 |
| comparison of immunogenicity and protective efficacy of genital herpes vaccine candidates herpes simplex virus 2 dl5-29 and dl5-29-41l in mice and guinea pigs. | a replication-defective herpes simplex virus (hsv)-2 vaccine, dl5-29, which is deleted for two essential early genes, ul5 and ul29, is highly immunogenic and protective in mice and guinea pigs. in a prior study, a derivative of hsv-2 dl5-29 termed dl5-29-41l, which has an additional deletion in ul41 (that encodes the virion-host shut-off protein), was more immunogenic and protective against challenge with wild-type hsv-2 in mice when compared with dl5-29. to determine if deletion of ul41 improve ... | 2008 | 18565628 |
| influenza virus infection and risk of acute myocardial infarction. | increasing evidences have shown that pathogens might promote atherosclerosis and trigger acute myocardial infarction (ami). but the conclusions from various studies on the correlation between previous influenza virus (iv) infection and ami were inconsistent. we conducted a case-control study to assess the association of previous iv infection and ami. questionnaire survey was conducted to collect information about demographic characteristics and heart disease risk factors. fasting blood sample wa ... | 2008 | 18568394 |
| inhibition of herpes simplex virus types 1 and 2 in vitro infection by sulfated derivatives of escherichia coli k5 polysaccharide. | herpes simplex virus type 1 (hsv-1) and hsv-2 are neurotropic viruses and common human pathogens causing major public health problems such as genital herpes, a sexually transmitted disease also correlated with increased transmission and replication of human immunodeficiency virus type 1 (hiv-1). therefore, compounds capable of blocking hiv-1, hsv-1, and hsv-2 transmission represent candidate microbicides with a potential added value over that of molecules acting selectively against either infect ... | 2008 | 18573926 |
| facile biocatalytic access to 9-fluorenylmethyl polyglycosides: evaluation of antiviral activity on immunocompetent cells. | the biological activities of a series of mono- and oligosaccharides (beta-xylosides and alpha-glucosides) of 9-fluorenylmethanol were investigated together with mono-beta-galactoside and beta-glucoside of this aglycone, produced by biocatalytic routes. by using marine glycoside hydrolases and inexpensive donors such as maltose or xylan, access to mono-alpha-glucoside or mono-beta-xyloside of 9-fluorenylmethanol was obtained. additionally, interesting polyglycoside derivatives were isolated. biol ... | 2008 | 18576391 |
| seroprevalence and risk factors associated with herpes simplex virus infection among pregnant women. | to estimate the type-specific seroprevalence and identify the risk factors associated with herpes simplex virus (hsv)-2 infection in pregnant women in bucharest, romania. | 2008 | 18576929 |
| acute and recurrent viral meningitis. | acute viral meningitis is the most common infection of the central nervous system. most cases occur in children and young adults and are due to enteroviruses. although the common causes of acute viral meningitis still lack treatment with an effective antiviral agent, management of patients is changing because of better and more rapid diagnostic tests to determine the exact viral etiology. these tests reduce the cost of workups and shorten hospitalizations. recurrent meningitis is less common, wi ... | 2008 | 18579020 |
| clients of female sex workers in gonaives and st-marc, haiti characteristics, sexually transmitted infection prevalence and risk factors. | few data exist on the role of clients of female sex workers (fsws) in sti transmission. this study examined sociodemographic characteristics, risk behaviors, and sti prevalence among clients of fsws in haiti. | 2008 | 18580821 |
| comparison of nested-polymerase chain reaction and virus culture for the diagnosis of genital herpes simplex virus infection. | this study was performed to compare nested-polymerase chain reaction (pcr) with viral culture as a diagnostic tool for genital herpes simplex virus (hsv) infection in a sexually transmitted infection (sti) clinic in singapore. | 2008 | 18581019 |
| herpes simplex virus 2 infection: a risk factor for hiv infection in heterosexuals. | genital ulcerative disease is one of the risk factors for acquisition of hiv. as hsv-2 infection is currently the most common cause of genital ulcerative disease, it acts as a potential risk factor for hiv infection. the present study was undertaken to know the seroprevalence of antibodies to hsv-2 in hiv seropositive individuals and in the general population, and to ascertain if hsv-2 is a risk factor for developing hiv infection. | 2008 | 18583789 |
| rapidly increasing incidence of kaposi's varicelliform eruption in patients with atopic dermatitis. | 2008 | 18583798 | |
| roles of clinical and subclinical reactivated herpes simplex virus type 2 infection and human immunodeficiency virus type 1 (hiv-1)-induced immunosuppression on genital and plasma hiv-1 levels. | few longitudinal studies have described the interactions between reactivation of herpes simplex virus type 2 (hsv-2) infection (hereafter, "hsv-2 reactivation") and genital and systemic replication of human immunodeficiency virus type 1 (hiv-1). | 2008 | 18593294 |
| effect of hiv-1 and antiretroviral therapy on herpes simplex virus type 2: a prospective study in african women. | to document the natural history of herpes simplex virus type 2 (hsv-2) in relation to hiv and highly active antiretroviral therapy (haart) in africa, a longitudinal study was conducted of women in the placebo arms of two randomised controlled trials of hsv-suppressive therapy in burkina faso. | 2008 | 18596069 |
| neuronal cytoskeletal dynamic modification and neurodegeneration induced by infection with herpes simplex virus type 1. | herpes simplex virus type 1 (hsv-1) and herpes simplex virus type 2 (hsv-2) belong to the family herpesviridae, the subfamily alphaherpesvirinae, and the genus simplexvirus. they are ubiquitous, neurotropic, and the most common pathogenic cause of sporadic acute encephalitis in humans. herpes simplex encephalitis (hse) is associated with a high mortality rate and significant neurological, neuropsychological, and neurobehavioral sequelae, which afflict patients for life. hsv-1 has been suggested ... | 2008 | 18599953 |
| herpes simplex encephalitis as an initial presentation of creutzfeldt-jakob disease. | 2008 | 18605370 | |
| viral sexually transmitted infections and bacterial vaginosis: 2001-2004 national health and nutrition examination survey data. | bacterial vaginosis (bv) is a common condition believed to be associated with sexually transmitted infection (sti) susceptibility. most studies of bv and stis have come from treatment-seeking or high-risk populations. this study examines the association between 5 viral stis, human papilloma virus (hpv), hiv, herpes simplex viruses types 1 and 2 (hsv-1 and hsv-2), and hepatitis c (hcv), and bv among women in the general us population. | 2008 | 18607314 |
| do protective behaviors follow the experience of testing positive for herpes simplex type 2? | to test the hypothesis that individuals attending a sexually transmitted disease (std) clinic would adopt sexual protective behaviors after receiving a positive test for herpes simplex virus 2 (hsv-2). | 2008 | 18607318 |
| successful kinase bypass with new acyclovir phosphoramidate prodrugs. | novel phosphoramidates of acyclovir have been prepared and evaluated in vitro against acyclovir-sensitive and -resistant herpes simplex virus (hsv) types 1 and 2 and varicella-zoster virus (vzv). unlike the parent nucleoside these novel phosphate prodrugs retain antiviral potency versus the acv-resistant virus strain, suggesting an efficient bypass of the viral thymidine kinase. | 2008 | 18614365 |
| high diagnostic yield by csf-pcr for entero- and herpes simplex viruses and tbev serology in adults with acute aseptic meningitis in stockholm. | acute aseptic meningitis (aam) affects 10-20/100,000 inhabitants per years in sweden. up to the beginning of the 1980s the diagnoses were made by virus isolation and/or determination of viral antibodies in serum. the development of pcr for detection of viruses in csf samples has increased the sensitivity and diagnostic efficiency considerably. we investigated the aetiology of aam and the diagnostic efficiency in an adult population in stockholm, using a limited first-line combination of microbio ... | 2008 | 18615360 |
| an immunomodulating dipeptide, scv-07, is a potential therapeutic for recurrent genital herpes simplex virus type 2 (hsv-2). | herpes simplex virus type 2 (hsv-2) infections produce a recurrent disease state associated with susceptibility to other pathogens, including human immunodeficiency virus (hiv), and cannot be cured by current therapeutic treatments. the hsv-2 epidemic must therefore be addressed by therapeutic strategies that reduce recurrent lesions and ideally lack the possibility for development of drug resistance. to this end, the therapeutic potential of scv-07 (gamma-d-glutamyl-l-tryptophan), a synthetic d ... | 2008 | 18619817 |
| famciclovir treatment options for patients with frequent outbreaks of recurrent genital herpes: the relief trial. | recurrent genital hsv outbreaks are common among those suffering from the disease. antiviral medications taken as suppressive therapy can reduce the frequency of these recurrences and reduce viral shedding occurring in between recurrences. | 2008 | 18621575 |
| prevalence and incidence of sexually transmitted infections among south indians at increased risk of hiv infection. | sexually transmitted infections (stis) have been identified as cofactors of hiv transmission. greater understanding of local sti burdens can assist in the development of more effective sti and hiv prevention strategies. the aim of this study is to determine the prevalence and incidence of stis among south indian men and women identified to be at increased risk for hiv infection. individuals at increased risk for hiv infection were enrolled in a prospective longitudinal study in chennai, india (n ... | 2008 | 18627276 |
| herpes vegetans as a sign of hiv infection. | herpes progenitalis can present in bizarre ways when seen in conjunction with altered immune status. in the recent past, a small number of individuals have been described with herpes vegetans, an exophytic, proliferative lesion that resembles either a verrucous or malignant growth. this phenomenon can occur on the digits, genitalia or perioral skin. we present a case of a vegetating penile plaque attributed to herpesvirus in an hiv-positive patient. | 2008 | 18627728 |
| [chronic virus infections in combination with tubercular process]. | the objective of this study was to investigate the role of chronic viral infections in development of the atypical and complicated forms of tuberculosis. were investigated human herpes virus-2 (hhv-2), cytomegalovirus (cmv) and hepatitis c virus (hcv). chronic viral infections have been identified as a risk factor for developing and complicated tuberculosis. research has been shown, that infection of chronic virus diseases in patients with tuberculosis is rather significant and in several times ... | 2008 | 18633150 |
| aseptic meningitis and encephalitis because of herpesviruses and enteroviruses in an immunocompetent adult population. | human herpesviruses (hhvs) and enteroviruses (evs) are the major causative agents of cns viral infections. the aim of the study was to identify the etiology and determine the frequency of aseptic meningitis and encephalitis due to hhvs and evs in an immunocompetent adult population. | 2008 | 18637823 |
| reconsideration of viral protein immunoblotting for differentiation of human herpes simplex viruses. | herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) are ubiquitous human pathogens that infect their hosts for life and reactivate to cause disease at or near the initial site of infection. as the incidence of genital hsv-1 infections increase, there is an increased demand for valid viral typing diagnostics. in this report, we reconsidered and developed a triple-phase immune-typing procedure that compares differences in electrophoretic mobilities of viral icp4, icp27, and vp22 proteins betwee ... | 2008 | 18639407 |
| herpes simplex virus type 2: epidemiology and management options in developing countries. | genital herpes simplex virus type 2 (hsv2) is highly prevalent worldwide and an increasingly important cause of genital ulcer disease (gud). continued hsv2 transmission is facilitated by the large number of undiagnosed cases, the frequency of atypical disease and the occurrence of asymptomatic shedding. the lack of easy, affordable diagnostic methods and specific antiviral treatment in countries with low and middle income is of great concern, given the ability of gud to enhance hiv transmission ... | 2008 | 18644920 |
| enhancement of protective humoral immune responses against herpes simplex virus-2 in dna-immunized guinea-pigs using protein boosting. | genital herpes is a common sexually transmitted disease that is caused mostly by herpes simplex virus type 2 (hsv-2). its prevalence has increased in developing countries in spite of the availability of valuable antiviral drug therapy. considering the importance of hsv-2 infections, effective vaccines remain the most likely hope for controlling the spread of hsv diseases. in the present study, the complete hsv-2 glycoprotein d gene was isolated and cloned into different plasmid vectors to constr ... | 2008 | 18647350 |
| herpes simplex virus and hiv-1: deciphering viral synergy. | recent proof-of-concept randomised controlled trials have shown a causal relation between herpes simplex virus (hsv) type 2 infection and hiv-1 replication in co-infected individuals. we explore the mechanisms that may operate to enhance reciprocal viral replication. direct interactions could involve hiv-1-related immune deficiency, disruption of mucosal barrier by hsv infection/reactivation, hsv-induced mucosal cell recruitment, transactivation of hiv-1 replication by hsv proteins, and immune m ... | 2008 | 18652995 |
| herpes simplex infections of the nervous system. | dramatic progress has been made recently in diagnosing and treating herpes simplex virus encephalitis (hsve). advances in imaging technology have greatly enhanced our ability to diagnose the illness noninvasively. acyclovir is of proven efficacy and is generally well-tolerated. the major clinical management problem is that the pathologic process in the brain is usually well-advanced before the patient presents, and the symptoms, particularly in newborns or infants, are often initially nonspecifi ... | 2008 | 18657720 |
| in vitro antiviral activity of distamycin a against clinical isolates of herpes simplex virus 1 and 2 from transplanted patients. | herpes simplex virus (hsv) infections in immunocompromised individuals may require prolonged antiviral therapy resulting in the emergence of viral strains resistant to the currently employed antiviral drugs. distamycin a (da), a basic antibiotic belonging to the lexitropsin dna minor groove binding drugs, exhibits antiviral properties. in this study we evaluated the in vitro cytotoxicity and antiviral activity of da against hsv type 1 and hsv type 2 clinical isolates from transplanted patients a ... | 2008 | 18663321 |
| co-infection of herpes simplex virus (hsv) with human immunodeficiency virus (hiv) in women with reproductive tract infections (rti). | in india, hsv seroprevalence and its coinfection with hiv among female patients with reproductive tract infections (rti) are sparse. we aim to ascertain the seroprevalence of hsv and its coinfection with hiv and common sexually transmitted infections attending obstetrics and gynaecology outpatient department, rims. the study included 92 female patients with rti. diagnostic serology was done for hsv-1 and hsv-2 using group specific igm indirect immunoassay using elisa, hiv by 3 elisa/rapid/simple ... | 2008 | 19245157 |
| comparison of cervicovaginal lavage, cervicovaginal lavage enriched with cervical swab, and vaginal tampon for the detection of hiv-1 rna and hsv-2 dna in genital secretions. | we compared the performance of 3 collection methods for cervicovaginal secretions [cervicovaginal lavage (cvl), cvl enriched with a cervical swab (ecvl), and vaginal tampon (vt)] to identify the most reliable method for detection of cervicovaginal hiv-1 and herpes simplex virus type 2 (hsv-2). hiv-1 rna (nuclisens easyq; biomerieux, marcy-l'etoile, france), hsv-2 dna (real-time polymerase chain reaction), and microscopic blood and semen traces were detected in samples from 19 hiv-1-hsv-2-coinfec ... | 2008 | 19186353 |
| group sex events and hiv/sti risk in an urban network. | to describe: (a) the prevalence and individual and network characteristics of group sex events (gses) and gse attendees; and (b) hiv/sexually transmitted infection (sti) discordance among respondents who said they went to a gse together. | 2008 | 19186355 |
| [human immunodeficiency virus/sexually transmitted infection, risk behavior and sexual networks among men who have sex with men in taizhou city, zhejiang province]. | to study the prevalence of human immunodeficiency virus (hiv), sexually transmitted infection (sti), risk behavior and the sexual networks among men who have sex with men (msm) in taizhou city, zhejiang province. | 2008 | 19173880 |
| [immunohistochemical expression of p16 and herpes simplex virus type 2 in squamous intraepithelial lesions and cervical cancer]. | to demonstrate the expression of biomarkers, detected by immunohistochemical techniques in healthy tissues, as well as in preneoplastic and neoplastic lesions of the uterine cervix. | 2008 | 19142477 |
| morphofunctional changes in guinea pig ovaries in experimental chronic herpesvirus infection. | the ovaries of adult guinea pigs infected with herpesvirus-2 were examined by light microscopy under conditions of latent infection and relapse of infectious process. morphofunctional changes in the ovarian follicles at all stages of folliculogenesis and in ovarian stroma were caused by the negative effects of type 2 herpes simplex virus. | 2008 | 19145331 |
| fimh adhesin of type 1 fimbriae is a potent inducer of innate antimicrobial responses which requires tlr4 and type 1 interferon signalling. | components of bacteria have been shown to induce innate antiviral immunity via toll-like receptors (tlrs). we have recently shown that fimh, the adhesin portion of type 1 fimbria, can induce the innate immune system via tlr4. here we report that fimh induces potent in vitro and in vivo innate antimicrobial responses. fimh induced an innate antiviral state in murine macrophage and primary mefs which was correlated with ifn-beta production. moreover, fimh induced the innate antiviral responses in ... | 2008 | 19057665 |
| [computer assessment of an apoptotic process dynamics in the nuclei of placental villi syncytiotrophoblast in puerperas after the outburst of herpes virus infection]. | the development of an apoptotic process in the nuclei of syncytiotrophoblast was studied in the placenta of 50 puerperas, who had the outburst of herpes virus infection in the second part of their pregnancy (antibody titre--1:12800). control group was represented by the placental material obtained from 20 women with no disease. apoptosis was demonstrated in paraffin sections of the material fixed in 10% buffered formalin by in situ labeling of dna fragments (isel-method). the assessment was perf ... | 2008 | 19241877 |
| comparative pathobiology of kaposi sarcoma-associated herpesvirus and related primate rhadinoviruses. | with the emergence of the aids epidemic over the last 2 decades and the more recent identification of kaposi sarcoma-associated herpesvirus (kshv, human herpesvirus 8), the genera of rhadinoviruses have gained importance as a family of viruses with oncogenic potential. first recognized in new world primates more than 30 y ago, the rhadinoviruses saimiriine herpesvirus 2 and ateline herpesvirus 2 have well-described transforming capabilities. recently several new species-specific rhadinoviruses o ... | 2008 | 19793454 |
| the genital tract immune milieu: an important determinant of hiv susceptibility and secondary transmission. | hiv is generally sexually acquired across the genital or rectal mucosa after exposure to the genital secretions of an hiv-infected partner. most exposures to hiv do not result in infection, likely due to protection afforded by an intact mucosal epithelium, as well as by innate and adaptive mucosal immune factors present in the genital tract. another important mucosal determinant of transmission may be the number and activation status of potential hiv target cells, including ccr5/cd4+ t cells and ... | 2008 | 17395270 |
| herpes simplex virus type 2 and hiv-1: the dialogue between the 2 organisms continues. | 2007 | 17396990 | |
| the role of herpes simplex virus type 2 and other genital infections in the acquisition of hiv-1 among high-risk women in northern tanzania. | we examined the role of herpes simplex virus type 2 (hsv-2) and other genital infections on human immunodeficiency virus type 1 (hiv-1) incidence in a cohort study conducted between 2002 and 2005 among female bar/hotel workers in moshi, tanzania. | 2007 | 17396994 |
| herpes simplex virus type 2 infection does not influence viral dynamics during early hiv-1 infection. | we sought to compare baseline and longitudinal plasma hiv-1 loads between herpes simplex virus type 2 (hsv-2)-seropositive and -seronegative individuals who are enrolled in a primary hiv-1 infection cohort in san diego, california. | 2007 | 17396995 |
| topical resiquimod 0.01% gel decreases herpes simplex virus type 2 genital shedding: a randomized, controlled trial. | resiquimod, an investigational immune response modifier and toll-like receptor (tlr) 7 and 8 agonist, stimulates production of cytokines that promote an antigen-specific t helper type 1 (th1)--acquired immune response. in animal models, induction of th1-specific responses modifies experimental herpes simplex virus (hsv) infection. | 2007 | 17397003 |
| a comprehensive murine model to evaluate topical vaginal microbicides: mucosal inflammation and susceptibility to genital herpes as surrogate markers of safety. | a critical gap in microbicide development is the absence of surrogate safety markers. the objective of the present study was to develop a murine model to examine the mucosal response to microbicides and to assess the functional implication of observed changes. mice received 14 daily intravaginal doses of nonoxynol-9, pro 2000, or placebo gel. nonoxynol-9 induced an inflammatory response characterized by increases in levels of cytokines and chemokines, recruitment of neutrophils and monocytes int ... | 2007 | 17397004 |
| interactions and management issues in hsv and hiv coinfection. | significant synergistic interactions have been observed between hiv and herpes simplex virus (hsv). hiv-induced immune compromise can cause frequent and persistent hsv disease, while poorly controlled hsv replication may influence hiv pathogenicity and transmission. hsv-2 seroprevalence is high in hiv-infected cohorts worldwide, with rates of over 80% for hsv-1 and ranging from 33% to more than 80% for hsv-2. as seen in hiv-negative individuals, hsv-2 coinfection is associated with female gender ... | 2007 | 17402838 |
| proportion of new hiv infections attributable to herpes simplex 2 increases over time: simulations of the changing role of sexually transmitted infections in sub-saharan african hiv epidemics. | to understand the changing impact of herpes simplex 2 (hsv-2) and other sexually transmitted infections (stis) on hiv incidence over time in four sub-saharan african cities, using simulation models. | 2007 | 17405782 |
| syphilis and other sexually transmitted diseases in hiv infection. | an ongoing resurgence of syphilis and continued transmission of other common sexually transmitted diseases (stds) in hiv-infected patients is fueled by a number of factors, including "prevention burnout" resulting from fatigue with long-term, safer-sex behavior, use of recretional drugs (notably methamphetamine), and false sense of security associated with hiv serosorting and elevated cd4+ cell count. annual screening for common stds is recommended for hiv-infected patients. issues in syphilis a ... | 2007 | 17406079 |
| herpes simplex virus latency-associated transcript sequence downstream of the promoter influences type-specific reactivation and viral neurotropism. | herpes simplex virus (hsv) establishes latency in sensory nerve ganglia during acute infection and may later periodically reactivate to cause recurrent disease. hsv type 1 (hsv-1) reactivates more efficiently than hsv-2 from trigeminal ganglia while hsv-2 reactivates more efficiently than hsv-1 from lumbosacral dorsal root ganglia (drg) to cause recurrent orofacial and genital herpes, respectively. in a previous study, a chimeric hsv-2 that expressed the latency-associated transcript (lat) from ... | 2007 | 17409161 |
| differential antiviral activity of benzastatin c and its dechlorinated derivative from streptomyces nitrosporeus. | benzastatin c, a 3-chloro-tetrahydroquinolone alkaloid from streptomyces nitrosporeus, showed antiviral activity in a dose-dependant manner with ec50 values of 1.92, 0.53, and 1.99 microg/ml against herpes simplex virus type 1 (hsv-1), herpes simplex virus type 2 (hsv-2), and vesicular stomatitis virus (vsv), respectively. in contrast, benzastatin d, the corresponding dechlorinated derivative, did not exhibit any antiviral activity. these results indicate that the antiviral activity of benzastat ... | 2007 | 17409523 |
| sexually transmitted disease and hiv prevalence and risk factors in concentrated and generalized hiv epidemic settings. | in many developing countries, the threat of nascent hiv epidemics expanding rapidly requires immediate and appropriate hiv prevention activities. inexpensive and sustainable interventions are especially relevant in resource-constrained environments. in 2001, we assessed the prevalence and behavioral risk of sexually transmitted disease (std) and hiv among at-risk populations in five developing countries in preparation for a community-randomized controlled trial, the nimh collaborative hiv/std pr ... | 2007 | 17413267 |
| prevalence of circumcision and herpes simplex virus type 2 infection in men in the united states: the national health and nutrition examination survey (nhanes), 1999-2004. | to study the prevalence of circumcision in the united states and to examine the association between circumcision and herpes simplex virus type 2 (hsv-2) infection. | 2007 | 17413536 |
| prevalence and determinants of hiv infection in south india: a heterogeneous, rural epidemic. | to assess the prevalence and determinants of hiv infection in the general population in bagalkot district, a largely rural district in the southern indian state of karnataka. | 2007 | 17413695 |
| suitability of a us3-inactivated hsv mutant (l1br1) as an oncolytic virus for pancreatic cancer therapy. | recently, the use of oncolytic viruses against cancer has attracted considerable attention. we studied the potential of the us3 locus-deficient herpes simplex virus (hsv), l1br1, for oncolytic virus therapy. its high specificity and potency indicate that l1br1 is a promising candidate as a new oncolytic virus against pancreatic cancer. moreover, the virus exhibited the unique characteristic of increasing apoptosis when used in combination with anticancer drugs. we assessed the feasibility of usi ... | 2007 | 17415379 |
| archipelago keratitis: a clinical variant of recurrent herpetic keratitis? | to describe archipelago keratitis, a presumed clinical variant of herpetic epithelial keratitis. | 2007 | 17418418 |
| perineal herpes simplex infection in bedridden geriatric patients. | herpes simplex virus (hsv) lesions are prone to reactivation and recurrence in response to various local or systemic triggering factors. | 2007 | 17428112 |
| differential responses of murine vaginal and uterine epithelial cells prior to and following herpes simplex virus type 2 (hsv-2) infection. | this study was undertaken to evaluate the susceptibility of upper and lower reproductive tract epithelial cells (ecs) to herpes simplex virus type 2 (hsv-2) infection and examine their cytokine secretion patterns prior to and following infection. | 2007 | 17430501 |
| multifocal posterior necrotizing retinitis. | to describe the clinical features of an acute, inflammatory, and progressive retinal necrosis that affects primarily the posterior pole. | 2007 | 17434436 |
| sexual behavior, knowledge of sti prevention, and prevalence of serum markers for sti among tour guides in cuzco/peru. | sexual behavior during travel has increasingly become a focus of travel medicine research. the perceived freedom when away from home can lead to increased casual sexual activities, often unprotected. local sexual partners, particularly those who are in close contact with tourists due to their occupation, need to be considered more in research. the purpose of this study was to explore the sexual behavior, knowledge of sti prevention, and prevalence of serum markers of selected stis in tour guides ... | 2007 | 17437470 |
| viral inhibition studies on sulfated lignin, a chemically modified biopolymer and a potential mimic of heparan sulfate. | 2007 | 17439173 | |
| [vaccines against herpex simplex virus infections. what's new]. | 2007 | 17450340 |