Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| using hepatitis c virus and herpes simplex virus-2 to track hiv among injecting drug users in new york city. | to explore the potential utility of hepatitis c virus (hcv) seroprevalence as a biomarker for injection risk, and herpes simplex virus-2 (hsv-2) as a biomarker for sexual risk among injecting drug users (idus). we examined the relationships between hcv and hiv and between hsv-2 and hiv among injecting drug users in new york city relative to the large-scale implementation of syringe exchange in the mid-1990s. | 2009 | 19108958 |
| risk factors for hiv incidence in women participating in an hsv suppressive treatment trial in tanzania. | a randomized, double-blind, placebo-controlled trial (rct) of herpes simplex virus type 2 suppressive therapy with acyclovir 400 mg twice daily conducted among women in northwestern tanzania reported a similar rate of hiv acquisition in both trial arms (current controlled trials number isrctn35385041). risk factors for hiv incidence were examined in the context of 3-monthly follow-up visits offering both voluntary counselling and testing and care for sexually transmitted infections. | 2009 | 19114859 |
| cell type-specific induction and inhibition of apoptosis by herpes simplex virus type 2 icp10. | herpes simplex virus (hsv) inhibits apoptosis induced by external stimuli in epithelial cells. in contrast, apoptosis is the primary outcome in hsv-infected lymphocytes. here, we show that hsv type 2 (hsv-2) gene expression appears to be necessary for the induction of apoptosis in jurkat cells, a t-cell leukemia line. hsv-2 icp10 gene expression is sufficient to induce apoptosis in jurkat cells, while its expression protects epithelial hep-2 cells from apoptosis triggered by cycloheximide and tu ... | 2009 | 19116254 |
| hsv-2 induces tlrs and nf-kappab-dependent cytokines in cervical epithelial cells. | herpes simplex virus type 2 (hsv-2) is one of the most common sexually transmitted pathogens worldwide. the host immune response induced by viral infection is cell-type specific. little is known about the innate immune response to this virus in its natural host cells. in this study, we established an in vitro hsv-2 infection model with human cervical epithelial (hce) cells. the viral infection was sufficient to induce expression of toll-like receptors (tlrs), and western blot and reporter assays ... | 2009 | 19124006 |
| herpes simplex virus: a histopathologic study of the depth of herpetic wounds. | herpes is a prevalent, infectious disease that can occur anywhere on the body; it is found primarily on the face and genitalia. herpes simplex virus type 1 (hsv-1) and herpes simplex virus type 2 (hsv-2) are the dna viruses that cause human herpes. clinically, hsv-1 and hsv-2 infections produce lesions generally located on the mucocutaneous junctions of the face and genitalia. at times, vesicular lesions may ulcerate, leaving recalcitrant wounds that are challenging to treat. until now, the basi ... | 2009 | 19126048 |
| serological diagnosis of human herpes simplex virus type 1 and 2 infections by luciferase immunoprecipitation system assay. | highly quantitative and high-throughput serological tests for evaluation of humoral responses to herpes simplex virus 1 (hsv-1) and hsv-2 are not available. the efficacy of luciferase immunoprecipitation system (lips) assays for antibody profiling and serologic diagnosis of hsv-1 and hsv-2 infection was investigated using a panel of five recombinant hsv antigens. plasma samples from subjects seropositive for hsv-1 and/or hsv-2 or seronegative for hsv-1 and hsv-2 that had previously been analyzed ... | 2009 | 19129469 |
| a genital tract peptide epitope vaccine targeting tlr-2 efficiently induces local and systemic cd8+ t cells and protects against herpes simplex virus type 2 challenge. | the next generation of needle-free mucosal vaccines is being rationally designed according to rules that govern the way in which the epitopes are recognized by and stimulate the genital mucosal immune system. we hypothesized that synthetic peptide epitopes extended with an agonist of toll-like receptor 2 (tlr-2), that are abundantly expressed by dendritic and epithelial cells of the vaginal mucosa, would lead to induction of protective immunity against genital herpes. to test this hypothesis, we ... | 2009 | 19129756 |
| hsv2 acute retinal necrosis: diagnosis and monitoring with quantitative polymerase chain reaction. | to describe a case of hsv2 acute retinal necrosis (arn) diagnosed and monitored with quantitative polymerase chain reaction (pcr) in ocular fluids. | 2009 | 18297242 |
| glycosaminoglycans are not indispensable for the anti-herpes simplex virus type 2 activity of lactoferrin. | lactoferrin has been recognized as a potent inhibitor of human herpetic viruses, such as herpes simplex type 1 (hsv-1) and 2 (hsv-2). in particular, bovine lactoferrin (blf) has been found to prevent viral infection by binding to heparan sulphate (hs) glycosaminoglycans (gags) that in turn can act as cell receptors for human herpetic viruses. in this study we further investigate the mechanism of inhibiting activity of both human lactoferrin (hlf) and blf against hsv-2. the antiviral effect of th ... | 2009 | 18534197 |
| antiviral activity of ancient system of ayurvedic medicinal plant cissus quadrangularis l. (vitaceae). | partially purified methanolic extract of cissus quadrangularis (belonging to vitaceae member, south indian medicinal plant) have been explored for antiviral activity and their phytochemical characterisation. in vitro antiviral activity against hsv type1 and 2, and vero cells at non-cytotoxic concentration were determined. hsv1 and hsv2 showed more sensitivity against the partially purified compound. phytochemical analysis showed the presence of the steroids and terpenoids. | 2009 | 25206252 |
| innate and adaptive immune responses to herpes simplex virus. | immune responses against hsv-1 and hsv-2 are complex and involve a delicate interplay between innate signaling pathways and adaptive immune responses. the innate response to hsv involves the induction of type i ifn, whose role in protection against disease is well characterized in vitro and in vivo. cell types such as nk cells and pdcs contribute to innate anti-hsv responses in vivo. finally, the adaptive response includes both humoral and cellular components that play important roles in antivir ... | 2009 | 21994578 |
| [relationship between primary ocular adnexal mucosa-associated lymphoid tissue lymphoma and eye infection]. | to study the role of pathogenic microorganisms commonly associated with chronic eye disease, including chlamydia psittaci, chlamydia trachomatis, chlamydia pneumoniae, herpes simplex virus (hsv) type 1 and type 2, and adenovirus type 8 and type 19, in the development of primary ocular adnexal mucosa-associated lymphoid tissue (malt) lymphoma in chinese patients. | 2009 | 20021960 |
| discussion and revision of the mathematical modeling tool described in the previously published article "modeling hiv transmission risk among mozambicans prior to their initiating highly active antiretroviral therapy". | mathematical models are increasingly used in social and behavioral studies of hiv transmission; however, model structures must be chosen carefully to best answer the question at hand and conclusions must be interpreted cautiously. in pearson et al. (2007), we presented a simple analytically tractable deterministic model to estimate the number of secondary hiv infections stemming from a population of hiv-positive mozambicans and to evaluate how the estimate would change under different treatment ... | 2009 | 20024742 |
| a macaque model to study vaginal hsv-2/immunodeficiency virus co-infection and the impact of hsv-2 on microbicide efficacy. | herpes simplex virus type-2 (hsv-2) infection enhances the transmission and acquisition of human immunodeficiency virus (hiv). this occurs in symptomatic and asymptomatic stages of hsv-2 infection, suggesting that obvious herpetic lesions are not required to increase hiv spread. an animal model to investigate the underlying causes of the synergistic action of the two viruses and where preventative strategies can be tested under such complex physiological conditions is currently unavailable. | 2009 | 20011586 |
| sexually transmitted infections among hiv-1-discordant couples. | more new hiv-1 infections occur within stable hiv-1-discordant couples than in any other group in africa, and sexually transmitted infections (stis) may increase transmission risk among discordant couples, accounting for a large proportion of new hiv-1 infections. understanding correlates of stis among discordant couples will aid in optimizing interventions to prevent hiv-1 transmission in these couples. | 2009 | 20011596 |
| association between hsv-2 and hiv serostatus in pregnant women of known hiv serostatus attending mulago hospital antenatal clinic, kampala, uganda. | studies show that stis such as hsv-2 increase the probability of hiv-1 acquisition and enhance transmission by increasing susceptibility and infectiousness respectively. the objective of this study was to compare the proportion of hsv-2 in hiv-positive and hiv-negative pregnant mothers attending the antenatal clinic in mulago teaching hospital in kampala, uganda. | 2009 | 20009284 |
| new concepts in understanding genital herpes. | herpes simplex virus (hsv)-2 is a lifelong infection that causes recurrent genital ulcers and, rarely, disseminated and visceral disease. hsv-1 infection is an increasingly important cause of genital ulcers. hsv infections are the most common cause of genital ulcers in adults, but acquisition and chronic infection are more commonly asymptomatic than symptomatic. both the symptomatic and asymptomatic forms of hsv are of clinical consequence for several reasons. hsv-2 infection enhances hiv-1 acqu ... | 2009 | 19857385 |
| [establishment and clinical application of a new real time pcr assay for simultaneous detection of human herpesvirus-6a and human herpesvirus-6b]. | human herpesvirus 6 (hhv-6) isolates are classified into two variants, hhv-6a and hhv-6b, based on distinct genetic, antigenic and biological characteristics. hhv-6 has been associated with encephalitis in children recently. this study aimed to establish a real time pcr assay for simultaneous detection of the two subtypes of hhv-6, and apply this new assay to children with suspected encephalitis, then analyze the relationship between the infection with hhv-6 and encephalitis in children. | 2009 | 19951517 |
| amphipathic dna polymers exhibit antiviral activity against systemic murine cytomegalovirus infection. | phosphorothioated oligonucleotides (ps-ons) have a sequence-independent, broad spectrum antiviral activity as amphipathic polymers (aps) and exhibit potent in vitro antiviral activity against a broad spectrum of herpesviruses: hsv-1, hsv-2, hcmv, vzv, ebv, and hhv-6a/b, and in vivo activity in a murine microbiocide model of genital hsv-2 infection. the activity of these agents against animal cytomegalovirus (cmv) infections in vitro and in vivo was therefore investigated. | 2009 | 19954538 |
| [association between hsv-2 infection and serum anti-rat brain antibodies in patients with autism]. | some cases of autism could be linked to viral infections able to induce autoimmune mechanisms directed against the encephalon. neurothophic virus infections in animals are associated with clinical signs that are similar to those observed in neurodevelopment disorders. thus, in this study, we determined the co-existence of antibodies against nerve tissue and viruses with neurothophic competence (hsv-1/2, epstein-barr-ebv, cytomegalovirus, measles and rubella) in serum of forty autistic children a ... | 2009 | 19961054 |
| decreasing prevalence of herpes simplex virus-2 antibodies in selected groups of women in sweden. | high estimates of herpes simplex virus-2 (hsv-2) seroprevalence have been reported for women who were pregnant in sweden in the 1980s, probably reflecting sexual risk-taking during the 1960s and 1970s. the aim of the present study was to evaluate the hsv-2 seroprevalence in pregnant women and in the female attendees at a clinic for sexually transmitted infections in sweden at the beginning of the 21st century and to compare the results with those of earlier swedish studies. sera were collected d ... | 2009 | 19997695 |
| seroprevalence of hiv, hsv-2, and treponema pallidum in the kosovarian population. | the objective of this study was to evaluate the seroprevalence of infection with hiv, herpes simplex virus type 2 (hsv-2), and treponema pallidum (tp) in a kosovarian population. a cross-sectional study was performed in peja, kosovo, from january to march 2005, among 1285 persons recruited at the peja hospital. the seroprevalence of hiv, hsv-2, and tp was evaluated, and the viral correlates for each infection were analysed. no hiv-positive cases were found. the seroprevalence of hsv-2 was 20.2%. ... | 2009 | 20001281 |
| viral hepatitis, hiv, human herpes virus and treponema pallidum infection in haemodialysis patients from kosovo, 2005. | the serological status of hepatitis viruses and other infectious diseases in the 66 dialysed patients of one haemodialysis unit in kosovo were studied, comparing the data with a large group of blood donors and out-patients. all dialysed patients were hepatitis a virus (hav) positive. prevalence of hepatitis b surface antigen (hbsag), hepatitis b surface antibodies (anti-hbs), and hepatitis b core antibodies (anti-hbc) was 14 of 66, 21% (95% confidence interval (ci): 12-33%), 5 of 66, 8% (95%ci: ... | 2009 | 20003903 |
| immunology: a helpers' guide to infection. | 2009 | 19940905 | |
| epidemiology of herpes simplex virus types 2 and 1 amongst men who have sex with men attending sexual health clinics in england and wales: implications for hiv prevention and management. | the objective was to investigate herpes simplex virus (hsv) epidemiology amongst hiv-positive and hiv-negative men who have sex with men (msm) in england and wales. unlinked anonymous sera from 3,968 msm attending 12 sexual health clinics in 2003 were tested for hiv, hsv-2 and hsv-1 antibodies. fifty-five percent of hiv-positive msm were hsv-2-seropositive, compared to 17% of hiv-negative msm (adj rr: 2.14 [ci: 1.92-2.37]). amongst hiv-positive individuals, there was no significant difference in ... | 2009 | 19941804 |
| relative hiv resistance in kenyan sex workers is not due to an altered prevalence or mucosal immune impact of herpes simplex virus type 2 infection. | chronic infection by herpes simplex virus type 2 (hsv-2) increases hiv susceptibility, perhaps due to hsv-2-associated increases in activated mucosal immune cells. a small number of kenyan female sex workers (fsws) exhibit relative hiv resistance. we examined whether relative hiv resistance was related to differences in the prevalence or mucosal immune impact of hsv-2. participants were recruited from an open cohort of hiv-uninfected fsws in nairobi, kenya. women who had been practicing sex work ... | 2009 | 19925401 |
| herpes simplex virus sepsis and acute liver failure. | acute liver failure is a life threatening disease mostly triggered by drug-induced or toxic liver damage or viral hepatitis. herpes simplex virus (hsv) hepatitis is rare and accounts for only 1% of all acute liver failures. the importance of hsv-induced acute liver failure is based on its extremely severe clinical course with lethality rates of almost 75%. hsv hepatitis is just one of several clinical manifestations of hsv sepsis leading more frequently to encephalitis, pneumonia and esophagitis ... | 2009 | 19930315 |
| prevalence of sexually transmitted infections among female adolescents aged 14 to 19 in the united states. | most young women initiate sexual activity during adolescence; risk for sexually transmitted infections (stis) accompanies this initiation. in this study we estimated the prevalence of the most common stis among a representative sample of female adolescents in the united states. | 2009 | 19933728 |
| effects of genital ulcer disease and herpes simplex virus type 2 on the efficacy of male circumcision for hiv prevention: analyses from the rakai trials. | randomized trials show that male circumcision (mc) reduces the incidence of hiv and herpes simplex virus type 2 (hsv-2) infections, and symptomatic genital ulcer disease (gud). we assessed the role of gud and hsv-2 in the protection against hiv afforded by mc. | 2009 | 19936044 |
| gammadelta t lymphocytes producing ifngamma and il-17 in response to candida albicans or mycobacterial antigens: possible implications for acute and chronic inflammation. | t lymphocytes bearing the gammadelta t cell receptor are known to play an important role in the first-line defense against viral, bacterial and fungal pathogens. two main subsets of gammadelta t cells are known, showing distinct functional behaviour: vdelta2 t lymphocytes, circulating in the peripheral blood, are involved in the response to mycobacterial infections and certain viruses, including coxsakie virus b3 and herpes simplex virus type 2. vdelta1 t cells are resident in the mucosal-associ ... | 2009 | 19903136 |
| fsl-1, a bacterial-derived toll-like receptor 2/6 agonist, enhances resistance to experimental hsv-2 infection. | herpes simplex virus type 2 (hsv-2) is a leading cause of genital ulceration that can predispose individuals to an increased risk of acquiring other sexually transmitted infections. there are no approved hsv-2 vaccines and current suppressive therapies require daily compound administration that does not prevent all recurrences. a promising experimental strategy is the use of toll-like receptor (tlr) agonists to induce an innate immune response that provides resistance to hsv-2 infection. previou ... | 2009 | 19903337 |
| childhood kikuchi-fujimoto disease. | to investigate the clinical features of kikuchi-fujimoto disease (kfd) and the relationship between viral infection and this disease in children will be better as kikuchi-fujimoto disease (kfd) is a lymphadenopathy. the aim of study is to investigate the clinical features of kfd and the relationship. the age, gender, clinical features and aetiopathogenesis of 36 chinese children with fkd were reviewed, and the viral antigens were detected. mean age was 10.1 +/- 2.8 yr with a male to female ratio ... | 2009 | 19904514 |
| herpes simplex virus in african american heterosexual males: the roles of age and male circumcision. | background:: male circumcision is protective against human immunodeficiency virus (hiv) and select other stis. the protective role of male circumcision in genital herpes simplex virus (hsv) infection and disease, however, remains controversial. methods:: we evaluated data from a sample of heterosexual black men attending a sexually transmitted diseases clinic to determine if circumcision status influenced hsv-1 and hsv-2 seroprevalence, clinical genital disease, or asymptomatic shedding. consent ... | 2009 | 19910861 |
| circumcision and risk of sexually transmissible infections in a community-based cohort of hiv-negative homosexual men in sydney, australia. | circumcision status was examined as an independent risk factor for sexually transmissible infections (stis) in the health in men cohort of homosexual men in sydney. | 2009 | 19911990 |
| prevalence of trichomonas vaginalis infection among young reproductive age women in india: implications for treatment and prevention. | trichomonas vaginalis infection is the most common curable sexually transmissible infection (sti) worldwide. the present study describes the burden and correlates of t. vaginalis infection among young reproductive age women in mysore, india. | 2009 | 19917204 |
| aging promotes neutrophil-induced mortality by augmenting il-17 production during viral infection. | morbidity and mortality associated with viral infections increase with age, although the underlying mechanisms are unclear. here, we investigated whether aging alters inflammatory responses during systemic viral infection and thereby contributes to virus-induced death. we found that infection of aged mice with systemic herpes viruses led to rapid increases in serum il-17, neutrophil activation, and mortality due to hepatocyte necrosis. in contrast, all young mice survived infection, displaying w ... | 2009 | 19917499 |
| distribution of herpes simplex virus type 1 and varicella zoster virus in ganglia of the human head and neck. | the distribution of the neurotropic alphaherpesviruses-herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) and varicella zoster virus (vzv)-was determined in autonomic and sensory ganglia of the head and neck obtained from formalin-fixed human cadavers. hsv-1 and vzv dna were found in 18 of 58 and 16 of 58 trigeminal, 23 of 58 and 11 of 58 pterygopalatine, 25 of 60 and 14 of 60 ciliary, 25 of 48 and 11 of 48 geniculate, 15 of 50 and 8 of 50 otic, 14 of 47 and 4 of 47 submandibular, 18 of 58 a ... | 2009 | 19919304 |
| mollaret meningitis may be caused by reactivation of latent cerebral toxoplasmosis. | mollaret meningitis (mm) occurs mainly in females and is characterized by recurrent episodes of headache, transient neurological abnormalities, and the cerebrospinal fluid containing mononuclear cells. hsv-2 was usually identified as the causative agent. recently, we found that recurrent headaches in non-hiv-infected subjects were due to acquired cerebral toxoplasmosis (ct). the aim of the study was therefore to focus on molecular pathomechanisms that may lead to reactivation of latent ct and ma ... | 2009 | 19922380 |
| role of hsv-2 suppressive therapy for hiv prevention. | 2009 | 19895212 | |
| cd8(+) t lymphocyte mobilization to virus-infected tissue requires cd4(+) t-cell help. | cd4(+) t helper cells are well known for their role in providing critical signals during priming of cytotoxic cd8(+) t lymphocyte (ctl) responses in vivo. t-cell help is required for the generation of primary ctl responses as well as in promoting protective cd8(+) memory t-cell development. however, the role of cd4 help in the control of ctl responses at the effector stage is unknown. here we show that fully helped effector ctls are themselves not self-sufficient for entry into the infected tiss ... | 2009 | 19898495 |
| isolation of acridone alkaloids and n-[(4-monoterpenyloxy)phenylethyl]-substituted sulfur-containing propanamide derivatives from glycosmis parva and their anti-herpes simplex virus activity. | six acridone alkaloids including a new glycosparvarine (1), three limonoids, and four n-[(4-monoterpenyloxy)phenylethyl]-substituted sulfur-containing propanamide derivatives including two new species, (+)-s-deoxydihydroglyparvin (10) and (+)-s-deoxytetrahydroglyparvin (11), were isolated from the branches and the leaves of glycosmis parva craib collected in the east of thailand. antiviral activity evaluation of isolates against herpes simplex virus (hsv) type 1 and 2 disclosed that two acridone ... | 2009 | 19881276 |
| [vitaherpavac is the first russian herpes simplex virus vaccine obtained on the vero b continuous cell line]. | vitaherpavac, a dry inactivated herpes simplex virus (hsv) culture vaccine, has been obtained, by using the vero b continuous cell line as a substrate for accumulation of herpes simplex virus types 1 (us strain) and 2 (vn strain). vitaherpavac and the similar vaccine herpovax made by the research institute of vaccines and sera, saint petersburg (for which preparation a primary trypsinized chick embryo cell culture used as a substrate for accumulation of hsv types 1 and 2), underwent comparative ... | 2009 | 19882901 |
| hsv type 2 infection increases hiv dna detection in vaginal tissue of mice expressing human cd4 and ccr5. | the goal of this study was to develop an in vivo murine model that can be used to study the influence of hsv-2 on hiv infection. mice expressing transgenes for human cd4, ccr5, and cyclin t1 were infected intravaginally with hsv-2 and 3-7 days later infected with hiv. hiv dna was detected by real-time pcr. the frequency of detection of hiv dna was significantly higher (65%) in vaginal tissue of hsv-2-infected mice compared to mock-infected mice (35%) when hiv was given 3 days after hsv-2. hsv-2- ... | 2009 | 19886831 |
| concentrated and linked epidemics of both hsv-2 and hiv-1/hiv-2 infections in senegal: public health impacts of the spread of hiv. | the objective of this article is to report seroprevalences on hiv and herpes simplex virus 2 (hsv-2) in female sex workers (fsw) and in two sentinel populations of pregnant women living in senegal. serosurveys of hiv and hsv-2 were conducted in two unselected sentinel populations from dakar, senegal, and its provinces, including in 2003 only pregnant women and 2006 pregnant women and fsw. the population study involved 888 pregnant women and 604 fsw. in pregnant women, hiv and hsv-2 seroprevalenc ... | 2009 | 19875833 |
| viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry. | herpes simplex virus type-1 and type-2 are highly prevalent human pathogens causing life-long infections. the process of infection begins when the virions bind heparan sulfate moieties present on host cell surfaces. this initial attachment then triggers a cascade of molecular interactions involving multiple viral and host cell proteins and receptors, leading to penetration of the viral nucleocapsid and tegument proteins into the cytoplasm. the nucleocapsid is then transported to the nuclear memb ... | 2009 | 19878306 |
| the prevalence of sexually transmitted and other lower reproductive tract infections among rural women in sichuan province, china. | to estimate the prevalence of sexually transmitted infections (sti) and lower reproductive tract infections (rti) and determine risk factors for sti among rural women in sichuan province, china, a cross-sectional, community-based cluster sample of 2,000 rural, married women were interviewed, examined and clinical specimens collected to assess for six sti and two non-sexually transmitted rti. the overall prevalence of any sti was 10.9% (95% ci 9.5-12.3); of any sti or rti was 30.8% (95% ci 28.7-3 ... | 2009 | 19842387 |
| in vitro antiviral activity of melaleuca alternifolia essential oil. | to investigate the in vitro antiviral activity of melaleuca alternifolia essential oil (tto) and its main components, terpinen-4-ol, alpha-terpinene, gamma-terpinene, p-cymene, terpinolene and alpha-terpineol. | 2009 | 19843207 |
| inhibition of herpes simplex virus by polyamines. | herpes simplex virus (hsv) establishes latent infection in humans with periodic reactivation. acyclovir, valacyclovir and foscarnet are in medical use today against hsv type-1 (hsv-1) and type-2 (hsv-2), inhibiting the dna synthesis of the viruses. additional drugs that will affect the growth of these viruses by other mechanisms and also decrease the frequency of appearance of drug-resistant mutants are required. | 2009 | 19843979 |
| aspects of herpes simplex virus: a clinical review. | 2009 | 19849918 | |
| herpes simplex virus type 2 tegument protein ul56 relocalizes ubiquitin ligase nedd4 and has a role in transport and/or release of virions. | the ubiquitin system functions in a variety of cellular processes including protein turnover, protein sorting and trafficking. many viruses exploit the cellular ubiquitin system to facilitate viral replication. in fact, herpes simplex virus (hsv) encodes a ubiquitin ligase (e3) and a de-ubiquitinating enzyme to modify the host's ubiquitin system. we have previously reported hsv type 2 (hsv-2) tegument protein ul56 as a putative adaptor protein of neuronal precursor cell-expressed developmentally ... | 2009 | 19835589 |
| liposomal gd ectodomain (gd1-306) vaccine protects against hsv2 genital or rectal infection of female and male mice. | herpes simplex virus type 2 (hsv2) is the most common causative agent of genital herpes, with infection rates as high as 1 in 6 adults. the present studies were done to evaluate the efficacy of a liposomal hsv2 gd(1-306) vaccine (l-gd(1-306)-hd) in an acute murine hsv2 infection model of intravaginal (female) or intrarectal (male or female) challenge. two doses of l-gd(1-306)-hd containing 60 microg gd(1-306)-hd and 15 microg monophosphoryl lipid a (mpl) per dose provided protection against hsv2 ... | 2009 | 19835825 |
| evasion of the mucosal innate immune system by herpes simplex virus type 2. | understanding the mechanisms by which herpes simplex virus (hsv) evades host immune defenses is critical to defining new approaches for therapy and prevention. we performed transcriptional analyses and immunocytochemistry on sequential biopsy specimens of lesional tissue from the acute through the posthealing phases of recurrent mucocutaneous hsv-2 infection. histological analysis of these biopsy specimens during the acute stage revealed a massive infiltration of t cells, as well as monocytes/ma ... | 2009 | 19793807 |
| genital herpes: an internet-based risk survey. | genital herpes is one of the most common sexually transmitted infections worldwide. we established a web-based survey to determine risk for genital herpes and encourage people to attend for herpes simplex virus testing. a survey was established on the australian herpes management forum (ahmf) website, consisting of 16 demographic and sexual health-related questions. each question carried a numerical risk-weighting based on epidemiological data; the higher the overall score, the greater the risk ... | 2009 | 19793847 |
| high prevalence of sexually transmitted infections among young peruvians who have sexual intercourse with foreign travelers in cuzco. | sexual networking in popular tourist destinations is a problem worldwide. in peru, locals sexually interacting with travelers bridge high-risk groups, the general population, and travelers. | 2009 | 19796098 |
| maternal and neonatal herpes simplex virus infections. | 2009 | 19797284 | |
| [eczema herpeticum caused by herpes simplex virus type 2. review of the literature about one case]. | eczema herpeticum is an extensive vesicular eruption caused by cutaneous dissemination of herpes simplex virus in patients who have underlying skin conditions or epidermal barrier disruption. herpes simplex virus type 1 (hsv 1) is the most common etiology. this is the first report in chile of a case of eczema herpeticum caused by hsv 2 in a patient with darier's disease, we review the literature and emphasize the use of sensitive and specific assays as real time polymerase chain reaction, that a ... | 2009 | 19802405 |
| infection of neurons and encephalitis after intracranial inoculation of herpes simplex virus requires the entry receptor nectin-1. | multiple entry receptors can mediate infection of cells by herpes simplex virus (hsv), permitting alternative pathways for infection and disease. we investigated the roles of two known entry receptors, herpesvirus entry mediator (hvem) and nectin-1, in infection of neurons in the cns and the development of encephalitis. wild-type, hvem ko, nectin-1 ko, and hvem/nectin-1 double ko mice were inoculated with hsv into the hippocampus. the mice were examined for development of encephalitis or were ki ... | 2009 | 19805039 |
| clinical correlates of herpes simplex virus viremia among hospitalized adults. | quantification of herpes simplex virus (hsv) dna in the peripheral blood is often used to evaluate patients suspected of having disseminated hsv infection. few studies have examined the clinical correlates of hsv viremia among adults. | 2009 | 19807272 |
| excoecarianin, isolated from phyllanthus urinaria linnea, inhibits herpes simplex virus type 2 infection through inactivation of viral particles. | phyllanthus urinaria linnea (euphorbiaceae) is one of the traditional medicinal plants widely used by oriental people to treat various diseases. we have previously demonstrated that the acetone extract of p. urinaria inhibits herpes simplex virus type 2 (hsv-2) but not hsv-1 infection. in a continuing effort to clarify the antiviral mechanisms of p. urinaria, we isolated the pure compound excoecarianin from the whole plant of p. urinaria through acetone extraction, and investigated its anti-hsv- ... | 2009 | 19808846 |
| screening for hsv-2 infection in std clinics and beyond: a few answers but more questions. | 2009 | 19809383 | |
| implementation of routine access to herpes simplex virus type 2 antibody testing in a public health sexually transmitted disease clinic. | testing for herpes simplex virus type 2 (hsv-2) antibody is not common in clinical practice. client characteristics associated with hsv-2 rapid antibody test uptake and test positivity were analyzed in clients attending an urban sexually transmitted disease clinic. | 2009 | 19809384 |
| infection and thyroid autoimmunity: a seroepidemiologic study of tpoaab. | infectious agents have been implicated as triggers of autoimmunity. prospective epidemiologic studies of infection with specific pathogens and the subsequent elevation of specific autoantibodies are difficult and costly to conduct. as a result, a solid body of evidence regarding this theoretically intriguing connection remains to be accrued. we studied term sera from 1807 pregnancies in 1591 women for whom igg status for cytomegalovirus, epstein-barr virus, herpes simplex virus type 1, herpes si ... | 2009 | 19811261 |
| obstructive endo-bronchial pseudotumour due to herpes simplex type 2 infection in an hiv-infected man. | we report a 31-year-old man with an obstructive bronchial lesion due to herpes simplex type 2 infection, who responded promptly to endoscopic resection and oral treatment with acyclovir. exophytic lesions of the respiratory tract are rare, potentially life-threatening, but readily treated complication of herpes simplex virus infection in hiv-infected individuals. | 2009 | 19815922 |
| herpes simplex virus infection and pemphigus. | pemphigus is a group of autoimmune blistering diseases of the skin and/or mucous membranes caused by the presence of antibodies against adhesion molecules on the cell surface of keratinocytes. in genetically predisposed patients, several factors, including drugs, physical agents, neoplasms, hormones, and viruses, notably herpes simplex virus (hsv), have been hypothesized to trigger or exacerbate the disorder. to clarify whether hsv infection represents an aetiopathogenetic factor for pemphigus o ... | 2009 | 19822095 |
| frequent release of low amounts of herpes simplex virus from neurons: results of a mathematical model. | herpes simplex virus-2 (hsv-2) is a sexually transmitted infection that is the leading cause of genital ulcers worldwide. infection is life long and is characterized by repeated asymptomatic and symptomatic shedding episodes of virus that are initiated when virus is released from neurons into the genital tract. the pattern of hsv-2 release from neurons into the genital tract is poorly understood. we fit a mathematical model of hsv-2 pathogenesis to curves generated from daily quantification of h ... | 2009 | 20161655 |
| sexually transmitted diseases and anorectum. | sexually transmitted diseases (std) are a major public health problem because their incidence is increasing worldwide despite prevention campaigns and because they raise the risk of hiv infection. anorectal localisations of std are common among men who have sex with men (msm) but can also be seen among heterosexuals (men or women). transmission of such infections is due to anal sex or to other sexual behaviours like "fisting". although some pathogens (like human papillomavirus-hpv) are common in ... | 2009 | 20163035 |
| [seroepidemiological surveys of non vaccine-preventable diseases and their interest in public health]. | seroepidemiological surveys are epidemiological studies carried out by the use of serum tests to detect infection; they can be applied to infections in general and to vaccine-preventable diseases in particular. among other applications, seroepidemiological studies are useful for determining groups at risk for a specific disease; evaluating transmission mechanisms; and determining population groups who are critical in maintaining the transmission of infectious agents. we analysed the results of s ... | 2009 | 20111813 |
| [hsv-1 and hsv-2 seropositivity rates in pregnant women admitted to izmir ataturk research and training hospital, turkey]. | in this study, the seropositivity rates of herpes simplex virus (hsv) types 1 and 2, and their distribution according to the age groups in the sera of asymptomatic pregnant women who were admitted to gynecology and obstetrics clinics of izmir ataturk research and training hospital for routine control, were investigated. igg and igm antibodies specific for hsv-1 and hsv-2 were screened by commercial elisa kits (radim spa-pomezia, italia). total igg seropositivity rates for hsv-1 and hsv-2 were fo ... | 2009 | 20084927 |
| successful increase in contraceptive uptake among kenyan hiv-1-serodiscordant couples enrolled in an hiv-1 prevention trial. | to evaluate a multipronged approach to promote dual contraceptive use by women within heterosexual hiv-1-serodiscordant partnerships. | 2009 | 20081393 |
| herpes simplex virus infections in solid organ transplant recipients. | 2009 | 20070669 | |
| herpesviridae and novel inhibitors. | herpesviridae comprises a large family of double-stranded dna viruses that infect both animals and humans. eight herpesviruses are known to infect humans: herpes simplex virus type-1 and -2, varicella zoster virus, human cytomegalovirus, epstein-barr virus, human herpesvirus 6 type-a and -b, human herpesvirus type-7 and -8 or kaposi's sarcoma virus. despite the fact that the past two decades have been evolutionary in the development of antiviral agents, therapeutic choices are restricted by limi ... | 2009 | 20032535 |
| susceptibility to genital herpes as a biomarker predictive of increased hiv risk: expansion of a murine model of microbicide safety. | a crucial gap in the development of microbicides for hiv prevention is the absence of models predictive of safety. previous studies have demonstrated an increased susceptibility to genital herpes in mice following repeated applications of nonoxynol-9 (n-9). this study was designed to explore the underlying mechanisms, focusing on the effects that n-9 has on genital tract epithelium and to apply this expanded model to evaluate the safety of microbicides that have been advanced to clinical trials. | 2009 | 20032541 |
| [mechanisms of chlamydia trachomatis and herpes simplex virus persistence during viral-bacterial infection]. | possible mechanisms of persistence on the example of chlamydia trachomatis in conditions of herpes simplex virus type 2 (hsv-2) superinfection in vitro and in vivo are described. emergence of persisting forms of chlamydia as well as factors influencing on this process are considered. contemporary views on pathogenesis of viral-bacterial infection with hsv-2 and c. trachomatis as well as interactions of the agents with local immunity factors are described. it was suggested that there are signalin ... | 2009 | 20066779 |
| effect of combinations of antiviral drugs on herpes simplex encephalitis. | 2-phenylamino-6-oxo-9-(4-hydroxybutyl)purine (hbpg) is a thymidine kinase inhibitor that prevents encephalitic death in mice caused by herpes simplex virus (hsv) types 1 and 2, although its potency is somewhat less than that of acyclovir (acv). the present study was undertaken to determine the effect of combinations of hbpg and either acv, phosphonoformate (pfa), or cidofovir (cdf) against hsv encephalitis. balb/c mice were given ocular infections with hsv-1 or hsv-2, and treated twice daily int ... | 2009 | 20054446 |
| a quick and parallel analytical method based on quantum dots labeling for torch-related antibodies. | quantum dot is a special kind of nanomaterial composed of periodic groups of ii-vi, iii-v or iv-vi materials. their high quantum yield, broad absorption with narrow photoluminescence spectra and high resistance to photobleaching, make them become a promising labeling substance in biological analysis. here, we report a quick and parallel analytical method based on quantum dots for torch-related antibodies including toxoplasma gondii, rubella virus, cytomegalovirus and herpes simplex virus type 1 ... | 2009 | 20652102 |
| verbascoside isolated from lepechinia speciosa has inhibitory activity against hsv-1 and hsv-2 in vitro. | verbascoside has been isolated form l. speciosa after several different chromatographic methods. after its purification, the structure has been unequivocally established using modern spectroscopic techniques. as for the antiviral activity, the maximum non toxic concentration has been established and this concentration has been used in the anti herpes assay, in vitro. mechanism of action for this molecule regarding the anti-herpes activity has been studied encompassing the following assays: viruc ... | 2009 | 20120109 |
| diagnosis of neurological herpesvirus infections: real time pcr in cerebral spinal fluid analysis. | human herpesviruses (hhvs) cause many serious acute and persistent central nervous system (cns) disorders. because these infections manifest with various, often non-specific, symptoms and signs, and because specific therapy is often available, accurate diagnosis is essential. cerebrospinal fluid (csf) from 146 patients with acute meningitis or meningoencephalitis and 9 with "other neurological disorders" were analyzed by using an automatic system for nucleic acid extraction and quantitative real ... | 2009 | 20128439 |
| left out but not forgotten: should closer attention be paid to coinfection with herpes simplex virus type 1 and hiv? | herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) are among the most common coinfections seen in individuals infected with hiv-1. most research on hsv-hiv coinfection has focused on hsv-2, and in particular, on its impact on hiv transmission. hsv-2 is associated with micro- and macroulcerations in genital mucosal surfaces, increased numbers of hiv target cells in genital mucosal tissue and increases in plasma hiv viral load of up to 0.5 log(10) copies/ml, such that hsv-2 infection increases ... | 2009 | 20190881 |
| [study on herpes simplex virus 2 infection and risky sexual behavior among hiv-infected patients in a county of yunnan province.]. | to explore the sero-prevalence and risk factors for herpes simplex virus 2 (hsv-2) infection and unprotected sexual behavior in an ethnically diverse population of hiv-infected subjects in a county of yunnan province. | 2009 | 20193582 |
| inhibition of herpes simplex virus type 2 by vaginal lactobacilli. | the protective effect of selected vaginal lactobacillus strains (l. brevis cd2, l. salivarius fv2, l. plantarum fv9) towards herpes simplex virus type 2 (hsv-2) infection in vitro has been analyzed. living bacterial cells affect different steps of virus multiplication. the effect on the early phases of virus infection appeared related to the bacterial adhesive potential to the cell membrane while all the strains strongly reduced intracellular events of virus multiplication. the anti hsv-2 activi ... | 2009 | 20224147 |
| frosted branch angiitis secondary to herpes simplex virus infection progressing to acute retinal necrosis. | to describe a case of frosted branch angiitis secondary to herpes simplex virus type 2 infection that progressed to acute retinal necrosis. | 2009 | 25390834 |
| magnetic resonance and diffusion-weighted imaging findings of herpes simplex encephalitis. | herpes simplex encephalitis (hse) is a rare, life-threatening disease. this paper draws attention to the role of imaging in early hse diagnosis. five consecutive patients diagnosed with hse (type 1) between june 2005 and june 2006 (three males, two females, mean age 44 [range 16-68] years) were included in this retrospective study. computed tomography, conventional magnetic resonance imaging (mri) sequences and diffusion-weighted imaging (dwi) were obtained for each patient. apparent diffusion c ... | 2008 | 18983763 |
| morphologic changes in fibroadenoma of breast due to chickenpox: a case report with suspicious cytology in fine needle aspiration smears. | fibroadenomas with stromal giant cell reaction have been described in the literature, but cytologic atypia including giant cell reaction due to chickenpox giving rise to suspicious cytology has not been reported. | 2008 | 18540301 |
| clinical validation of a new triplex real-time polymerase chain reaction assay for the detection and discrimination of herpes simplex virus types 1 and 2. | a new triplex real-time polymerase chain reaction (pcr) assay for herpes simplex virus (hsv) (artus hsv-1/2 tm pcr kit, qiagen) was evaluated. this assay simultaneously uses three differently labeled probes targeted to hsv-1 (fam), hsv-2 (ned), and to the manufacturer's internal control (vic). hsv-1/2 typing capability and quantitation accuracy were determined using hsv stocks and quality control panels. performance in routine clinical testing was compared with a nested hsv-1/2 pcr assay. diluti ... | 2008 | 18556766 |
| comparison of automated nucleic acid extraction methods with manual extraction. | automated nucleic acid extractors can improve workflow and decrease variability in the clinical laboratory. we evaluated qiagen ez1 (valencia, ca) and biomérieux (durham, nc) easymag extractors compared with qiagen manual extraction using targets and matrices commonly available in the clinical laboratory. pooled samples were spiked with various organisms, serially diluted, and extracted in duplicate. the organisms/matrices were bordetella pertussis/bronchoalveolar lavage, herpes simplex virus ii ... | 2008 | 18556770 |
| a replication-competent, neuronal spread-defective, live attenuated herpes simplex virus type 1 vaccine. | herpes simplex virus type 1 (hsv-1) produces oral lesions, encephalitis, keratitis, and severe infections in the immunocompromised host. hsv-1 is almost as common as hsv-2 in causing first episodes of genital herpes, a disease that is associated with an increased risk of human immunodeficiency virus acquisition and transmission. no approved vaccines are currently available to protect against hsv-1 or hsv-2 infection. we developed a novel hsv vaccine strategy that uses a replication-competent str ... | 2008 | 18562543 |
| detection and quantitative analysis of human herpesvirus in pilocytic astrocytoma. | we investigated the hypothetical role of human herpesviruses (hhvs) in tumour formation of the cerebellum. thirty-five samples of pilocytic astrocytoma and 10 control samples of cerebellum from patients who died of unrelated diseases were examined. presence of the 8 known hhvs was first studied using specific real-time quantitative polymerase chain reaction (qpcr) targeting viral dna polymerase. hhv's dna polymerase was found present in 20 samples (7 controls, 13 astrocytomas) and was absent in ... | 2008 | 18565499 |
| prevalence of hiv, herpes simplex virus-2, and syphilis in male sex partners of pregnant women in peru. | sexually active heterosexual men may represent an important risk factor for hiv infection and sti transmission to their female partners and unborn children, though little is known about the prevalence of stis in this population. we sought to determine the prevalence of hiv, herpes simplex virus type 2 (hsv-2), and syphilis infection and associated risk behaviors among male sex partners of pregnant women in peru. | 2008 | 18284696 |
| acute retinal necrosis secondary to herpes simplex virus type 2 with preexisting chorioretinal scarring. | acute retinal necrosis in children is a devastating disease that requires early diagnosis and treatment. the authors describe a rarely reported case of bilateral acute retinal necrosis in a child caused by neonatal herpes simplex virus type 2, where the presence of previous chorioretinal scarring made diagnosis challenging. | 2008 | 18286969 |
| seroprevalences of herpes simplex virus type 2, five oncogenic human papillomaviruses, and chlamydia trachomatis in katowice, poland. | herpes simplex virus type 2 (hsv-2), human papillomaviruses (hpvs), and chlamydia trachomatis are the most common pathogens causing sexually transmitted infections (stis). there is limited information about the prevalences of these stis in poland. here, we estimated the occurrence of immunoglobulin g (igg) antibodies against hsv-2, hpv, and c. trachomatis in 199 blood donors and 110 patients of both genders attending an sti clinic in katowice in southern poland. the seroprevalences of hsv-2 were ... | 2008 | 18287578 |
| relative efficiency of polymerase chain reaction and enzyme-linked immunosorbant assay in determination of viral etiology in congenital cataract in infants. | perinatal viral infections of fetus are among the leading causes of congenital cataract and identifying the viral etiology is important. | 2008 | 18296799 |
| herpes simplex virus seroprevalence among children, adolescents and adults in greece. | the aim was to study the type-specific seroprevalence of herpes simplex virus (hsv)-1 and hsv-2 infections and the associated risk factors in children, adolescents and adults in greece. a total of 1867 serum samples from children, adolescents and adults of both genders aged from 0 to 60 years were collected from three large hospital-referral centres in athens. all sera were tested for type-specific antibodies to hsv-1 and hsv-2 using herpeselect igg elisa tests (focus diagnostics cypress, cal, u ... | 2008 | 18482949 |
| [mutational pressure in genomes of alphaherpesviruses infecting human]. | genomes of the herpes simplex viruses are extremely enriched with gc. elevated g+c level in genomes of the simplex viruses is a result of their long-term evolution under the influence of the mutational pressure. we counted the rates of nucleotide substitutions from gene coding major capsid protein (mcp) (g+c = 0.68, 3gc = 0.89) of human simplex virus 1 (hsv-1) to the mcp gene (g+c = 0.70, 3gc = 0.91) of hsv-2 (the first pair of genes) and from the same mcp gene of hsv-1 to the homologous gene (g ... | 2008 | 18488448 |
| icp10pk inhibits calpain-dependent release of apoptosis-inducing factor and programmed cell death in response to the toxin mpp+. | apoptosis is a widely accepted component of the pathogenesis of parkinson's disease (pd), a debilitating neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra. however, additional death programs were implicated, and current understanding of the cycle of intracellular events that leads to the demise of these neuron jis limited. gene therapy strategies were proposed to inhibit apoptosis, but they have met with relatively limited success. here we report th ... | 2008 | 18496573 |
| detection of hsv type-1 and type-2 igg using an in vitro pca based homogeneous immunoassay. | enzyme immunoassays (eias) are widely used in the clinical laboratory and research institutes for the detection of biologically relevant analytes. almost all eias are heterogeneous in nature and require multiple steps of process. in contrast, homogeneous immunoassays (ha) offer a simplified one-step approach with a number of potential advantages over contemporary heterogeneous eias such as higher throughput and greater clinical utility. utilizing tem-1 beta-lactamase as a reporter enzyme, we hav ... | 2008 | 18503749 |
| amphipathic dna polymers exhibit antiherpetic activity in vitro and in vivo. | phosphorothioated oligonucleotides have a sequence-independent antiviral activity as amphipathic polymers (aps). the activity of these agents against herpesvirus infections in vitro and in vivo was investigated. the previously established sequence-independent, phosphorothioation-dependent antiviral activity of aps was confirmed in vitro by showing that a variety of equivalently sized homo- and heteropolymeric ap sequences were similarly active against herpes simplex virus type 1 (hsv-1) infectio ... | 2008 | 18505857 |
| expression of the herpes simplex virus type 2 glycoprotein d in baculovirus expression system and evaluation of its immunogenicity in guinea pigs. | herpes simplex virus type 2 (hsv-2) is highly prevalent and major cause of genital herpes in humans. the life-long nature of infection and the increasing prevalence of genital herpes imply that vaccination is the best strategy for controlling the spread of infection and limiting hsv disease. hsv glycoprotein d (gd) is one of the most important viral immunogen which has an essential role in virus infectivity and induction of immune responses. | 2008 | 18506211 |
| comparison of three commercial immunoassays for detection of herpes simplex virus type 2 antibodies in commercial sex workers in yunnan province, china. | five hundred commercial sex workers in china were tested for herpes simplex virus type 2 by three immunoassays and western blotting. sensitivities for the focus, kalon, and biokit assays were 86.7%, 82.3%, and 34.9%, respectively, and specificities were 91.8%, 94.2%, and 60.1%, respectively. the focus assay performed optimally at an index of 1.5 (95.2% sensitivity and 93.4% specificity), and the kalon assay performed optimally at an index of 1.2 (93.3% sensitivity and 95.2% specificity). | 2008 | 18508932 |
| hiv-1, hsv-2 and syphilis among pregnant women in a rural area of tanzania: prevalence and risk factors. | evidence suggests that a substantial proportion of new hiv infections in african countries are associated with herpes simplex virus type 2 (hsv-2). thus, the magnitude of hsv-2 infection in an area may suggest the expected course of the hiv epidemic. we determined prevalence of genital herpes, syphilis and associated factors among pregnant women from a remote rural tanzanian community that has a low but increasing hiv prevalence. | 2008 | 18513451 |
| efficient amplification with nasba of hepatitis b virus, herpes simplex virus and methicillin resistant staphylococcus aureus dna. | a new mechanism is described for dna amplification using nucleic acid sequence-based amplification (nasba) including a restriction enzyme digestion and p1 primer binding directly upstream of the digestion. for hepatitis b virus (hbv), herpes simplex virus (hsv) and methicillin resistant staphylococcus aureus (mrsa) dna, which all show very poor amplification with normal nasba, assay sensitivity was improved by a factor 100-1000 when restriction enzyme digestion was performed prior to amplificati ... | 2008 | 18514336 |