Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| herpes viruses in transplant recipients: hsv, vzv, human herpes viruses, and ebv. | the herpes viruses are responsible for a wide range of diseases in patients following transplant, resulting from direct viral effects and indirect effects, including tumor promotion. effective treatments and prophylaxis exist for the neurotropic herpes viruses hsv-1, hsv-2, varicella zoster virus, and possibly hhv-6. antivirals seem to be less effective at prevention of the tumor-promoting effects of epstein-barr virus and hhv-8. reduction in immunosuppression is the cornerstone to treatment of ... | 2010 | 20466275 |
| lipophile-conjugated sulfated oligosaccharides as novel microbicides against hiv-1. | with the aim of providing compounds suitable for further development as microbicides active against human immunodeficiency virus 1 (hiv-1) a library containing 37 lipophile-conjugated sulfated oligosaccharides was screened for antiviral and virucidal activity against this virus. four highly active compounds had low drug inhibition concentrations (ic(50)) for hiv-1 and inactivated viral particles, suggestive of virucidal properties. two of these compounds comprising a sulfated tetrasaccharide lin ... | 2010 | 20307578 |
| [establishment of a cell model system of herpes simplex virus type ii latent infection and reactivation in sh-sy5y cells]. | to establish an experimental culture system of herpes simplex virus type ii (hsv-2) latent infection and reactivation in sh-sy5y cells. | 2010 | 20344947 |
| new analogues of acyclovir--synthesis and biological activity. | new acyclovir esters with peptidomimetics were synthesized and evaluated in vitro for their antiviral activity against the replication of herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2). the influence of peptidomimetics containing oxazole and thiazolyl-thiazole moieties on the antiviral activity is also reported. the esters were synthesized using the coupling reagents n-ethyl-n'-(3-dimethylaminopropyl)carbodiimide hydrochloride (edc) and n,n-dimethyl-4-aminopyridine (dmap) as a catalyst. | 2010 | 20355317 |
| cervicovaginal fluid and semen block the microbicidal activity of hydrogen peroxide produced by vaginal lactobacilli. | h2o2 produced by vaginal lactobacilli is believed to protect against infection, and h2o2-producing lactobacilli inactivate pathogens in vitro in protein-free salt solution. however, cervicovaginal fluid (cvf) and semen have significant h2o2-blocking activity. | 2010 | 20482854 |
| immunostimulating effects of a sulfated galactan from codium fragile. | a pyruvylated sulfated galactan from codium fragile is a highly ramified polysaccharide consisting of 3-linked, 3,6-linked, and non-reducing terminal d-galactose with pyruvate and sulfate groups; the glycan exerts anti-herpes simplex virus type 2 effects in vitro and in vivo. this particular polysaccharide was found to stimulate the production of nitric oxide by inducing inos at the mrna and protein levels. in addition, the polysaccharide also induced several cytokine mrna expressions such as il ... | 2010 | 20362278 |
| [inactivated herpes simplex virus types 1 and 2 divaccine as an agent for effective immunoprophylaxis of recurrent genital herpes]. | prevention of recurrent genital herpes with the inactivated herpetic divaccine vitaherpavac against herpes simplex virus types 1 and 2 has a number of advantages over the most commonly used symptomatic therapy: it ceases or significantly reduces the number of recurrences and accordingly prolongs a relapse-free interval, abolishes viremia and the manifestations of clinical symptoms of recurrences, induces no dependence to the vaccine. coadministration of the vitaherpavac vaccine and the immunomod ... | 2010 | 20364670 |
| a rare case of absent corpus callosum with severe ventriculomegaly due to congenital herpes simplex infection. | 2010 | 20373944 | |
| effectiveness of hiv prevention for youth in sub-saharan africa: systematic review and meta-analysis of randomized and nonrandomized trials. | systematically assess the effectiveness of hiv-prevention interventions in changing sexual behaviour of young people (10-25 years) in sub-saharan africa. | 2010 | 20375876 |
| clinical reactivations of herpes simplex virus type 2 infection and human immunodeficiency virus disease progression markers. | the natural history of hsv-2 infection and role of hsv-2 reactivations in hiv disease progression are unclear. | 2010 | 20376310 |
| chronic viral infection and primary central nervous system malignancy. | primary central nervous system (cns) tumors cause significant morbidity and mortality in both adults and children. while some of the genetic and molecular mechanisms of neuro-oncogenesis are known, much less is known about possible epigenetic contributions to disease pathophysiology. over the last several decades, chronic viral infections have been associated with a number of human malignancies. in primary cns malignancies, two families of viruses, namely polyomavirus and herpesvirus, have been ... | 2010 | 20387126 |
| herpes simplex virus infects skin gamma delta t cells before langerhans cells and impedes migration of infected langerhans cells by inducing apoptosis and blocking e-cadherin downregulation. | the role individual skin dendritic cell (dc) subsets play in the immune response to hsv remains unclear. we investigated the effect of hsv on dc virus uptake, viability, and migration after cutaneous infection in vitro and in vivo. hsv increased the emigration of skin dcs from whole skin explants over 3 d postinfection (p.i.) compared with mock controls, but the kinetics of emigration was influenced by the skin dc subset. uninfected (bystander) langerhans cells (lcs) were the major emigrant dc s ... | 2010 | 20519652 |
| immunization with a dominant-negative recombinant herpes simplex virus (hsv) type 1 protects against hsv-2 genital disease in guinea pigs. | cj9-gd is a novel dominant-negative recombinant herpes simplex virus type 1 (hsv-1) that is completely replication-defective, cannot establish detectable latent infection in vivo, and expresses high levels of the major hsv-1 antigen glycoprotein d immediately following infection. in the present study, cj9-gd was evaluated as a vaccine against hsv-2 genital infection in guinea pigs. | 2010 | 20525279 |
| aspects of human disease: 48. herpesvirus infections. | 2010 | 20527503 | |
| even nhanes evolves: some surprising findings about women who have sex with women. | 2010 | 20531028 | |
| prevalence- and gender-specific immune response to opportunistic infections in hiv-infected patients in lesotho. | the objective of this study was to assess the seroprevalence of coinfecting viruses and treponema pallidum (t. pallidum) in a cohort of 205 antiretrovirally treated hiv-infected individuals (152 females and 53 males, aged: 19-71 years) in rural lesotho. furthermore agent-specific immune responses were investigated by analyzing antibody titers against herpes simplex virus type 2 (hsv-2) and against t. pallidum. | 2010 | 20531031 |
| women who have sex with women in the united states: prevalence, sexual behavior and prevalence of herpes simplex virus type 2 infection-results from national health and nutrition examination survey 2001-2006. | to estimate the prevalence of same-sex sexual behavior in women in the united states; to describe demographic and behavioral characteristics and the prevalence of herpes simplex virus type 2 (hsv-2) infection. | 2010 | 20531032 |
| asp2151, a novel helicase-primase inhibitor, possesses antiviral activity against varicella-zoster virus and herpes simplex virus types 1 and 2. | to evaluate and describe the anti-herpesvirus effect of asp2151, amenamevir, a novel non-nucleoside oxadiazolylphenyl-containing herpesvirus helicase-primase complex inhibitor. | 2010 | 20534624 |
| apoptosis induction after herpes simplex virus infection differs according to cell type in vivo. | we compared apoptosis induction in mice following three routes of infection. after intravenous infection, wild-type herpes simplex virus (hsv) types 1 and 2 and us3delta mutants infected the adrenal gland and caused apoptosis. corneal infection with wild-type virus resulted in apoptosis in a fraction of infected epithelium cells. interestingly, many uninfected cells were apoptotic in the retina. although neurons in the trigeminal ganglion were heavily infected, no apoptotic neurons were observed ... | 2010 | 20535504 |
| abundant expression of hiv target cells and c-type lectin receptors in the foreskin tissue of young kenyan men. | a biological explanation for the reduction in hiv-1 (hiv) acquisition after male circumcision may be that removal of the foreskin reduces the number of target cells for hiv. the expression of potential hiv target cells and c-type lectin receptors in foreskin tissue of men at risk of hiv infection were thus analyzed. thirty-three foreskin tissue samples, stratified by herpes simplex virus type 2 status, were obtained from a randomized, controlled trial conducted in kenya. the samples were analyze ... | 2010 | 20395432 |
| anti-hsv activity of camptothecin analogues. | in order to explore the range of biological activities of the camptothecin compound class, the in vitro antiviral efficacies of series i-iv of representative members from camptothecin analogues on herpes simplex virus type 2 (hsv-2) were evaluated on vero cells. several compounds exhibited similar or better antiviral activity against hsv-2 in vitro than acyclovir. among them, compound 6 showed the highest anti-hsv-2 activity, with ic(50) values of 1.3 microg ml(-1) and si values of 27.04, respec ... | 2010 | 20397103 |
| recurrent meningitis attributable to herpes simplex virus-2 in a child. | a boy manifested episodes of recurrent meningitis that were attributed to herpes simplex virus-2 infection. he presented no concurrent or previous history of involvement of the genitourinary system. he exhibited headaches, dizziness, photophobia, loss of balance, and vomiting. he underwent three episodes of aseptic meningitis. the herpes simplex virus-2 etiology was confirmed by polymerase chain reaction of the cerebrospinal fluid in the last two episodes. after the third occurrence, he was trea ... | 2010 | 20399396 |
| seroprevalence of herpes simplex virus type 2 among persons aged 14-49 years--united states, 2005-2008. | herpes simplex virus type 2 (hsv-2) is one of the most common sexually transmitted infections worldwide and the primary cause of genital and neonatal herpes and genital ulcer disease. multiple studies have shown that hsv-2 infection increases the risk for human immunodeficiency virus (hiv) infection by at least twofold. hsv-2 infection is lifelong, and serologic testing provides the best method to estimate hsv-2 prevalence. since 1976, cdc has monitored hsv-2 seroprevalence in the united states ... | 2010 | 20414188 |
| neighbor effects of neurons bearing protective transgenes. | viral vectors bearing protective transgenes can decrease neurotoxicity after varied necrotic insults. a neuron that dies necrotically releases glutamate, calcium and reactive oxygen species, thereby potentially damaging neighboring neurons. this raises the possibility that preventing such neuron death via gene therapy can secondarily protect neighboring neurons that, themselves, do not express a protective transgene. we determined whether such "good neighbor" effects occur, by characterizing neu ... | 2010 | 20417625 |
| epstein-barr virus in bone marrow of rheumatoid arthritis patients predicts response to rituximab treatment. | viruses may contribute to ra. this prompted us to monitor viral load and response to anti-cd20 therapy in ra patients. | 2010 | 20547657 |
| pathogenesis of primary acquired nasolacrimal duct obstruction. | to assess the factors assumed to be contributed in pathogenesis of primary acquired nasolacrimal duct obstruction (pando). | 2010 | 20302403 |
| herpes infects one in six in united states. | 2010 | 20405533 | |
| apoe genotype is associated with oral herpetic lesions but not genital or oral herpes simplex virus shedding. | apolipoprotein e is polymorphic in the human population. apoe4 has previously been reported to correlate with symptomatic oral and genital herpes disease. | 2010 | 20410080 |
| characterization of structures and antiviral effects of polysaccharides from portulaca oleracea l. | three polysaccharides including a neutral polysaccharide (rn), an acidic polysaccharide (ra) and a pectic polysaccharide (rp) were isolated from aerial part of portulaca oleracea l. and evaluated for their anti-herpes simplex virus type 2 (hsv-2) and anti-influenza a virus (ifv-a). rn was found to consist of glucose (glc), mannose (man) and arabinose (ara) with small amounts of galactose (gal), and identified to be an arabinoglucomannan. ra was mainly composed of gal and ara with a small proport ... | 2010 | 20410633 |
| increased risk of hiv acquisition among kenyan men with human papillomavirus infection. | few data on the effect of human papillomavirus (hpv) infection on human immunodeficiency virus (hiv) acquisition are available. | 2010 | 20415595 |
| the ig-like v-type domain of paired ig-like type 2 receptor alpha is critical for herpes simplex virus type 1-mediated membrane fusion. | paired immunoglobulin (ig)-like type 2 receptor alpha (pilralpha) and pilrbeta are paired receptors that are highly homologous to each other. when engaged by ligand, pilralpha is inhibitory whereas pilrbeta is activating. pilralpha is a newly identified herpes simplex virus type 1 (hsv-1) glycoprotein b (gb) receptor and is associated with membrane fusion and entry activity of hsv-1. pilralpha is a 303-amino-acid protein with an ig-like v (variable)-type domain from amino acid 31 to 150, whereas ... | 2010 | 20573830 |
| etiology of dna virus infections in liver transplant recipients with neonatal hepatitis. | neonatal hepatitis is a syndrome of symptoms associated with a history that includes any type of infectious, genetic, toxic, or metabolic causation. various infectious agents have been implicated in hepatic inflammation in neonates including bacterial and viral pathogens, especially dna viruses. we used molecular and antigenic methods to evaluate the role of dna viruses, such as hepatitis type b viruses (hbv), human cytomegalovirus (hcmv), herpes simplex virus (hsv), and adenovirus, in neonatal ... | 2010 | 20430185 |
| follow the footprints to the diagnosis in a patient with meningismus. | 2010 | 20433354 | |
| impact of aciclovir on ulcer healing, lesional, genital and plasma hiv-1 rna among patients with genital ulcer disease in malawi. | by a randomised, double-blind, placebo-controlled trial of aciclovir 800 mg twice daily for 5 days added to the syndromic management of genital ulcer disease (gud) to determine the impact on ulcer healing and hiv outcomes. | 2010 | 20444742 |
| herpes simplex virus type 2 enhances hiv-1 susceptibility by affecting langerhans cell function. | genital herpes is the most prevalent viral sexually transmitted infection worldwide and is mainly caused by hsv type 2 (hsv-2). hsv-2 infection enhances hiv-1 susceptibility, even in the absence of clinical symptoms. in this study, we investigated the effect of hsv-2 on hiv-1 transmission by mucosal langerhans cells (lcs). lcs are important in heterosexual transmission because they form a barrier against hiv-1 infection; lcs efficiently capture and degrade hiv-1 through the c-type lectin langeri ... | 2010 | 20592277 |
| [investigation of herpes simplex virus (hsv) by three different methods in the clinical specimens of patients with suspected hsv infections]. | herpes simplex virus (hsv) infections are a common clinical problem worldwide. hsv infections have a severe and rapidly progressive course especially in immunocompromised patients, leading to significant morbidity and mortality. therefore, rapid and reliable laboratory diagnosis of hsv infections is of crucial importance for the initiation of early antiviral therapy. in this study the aim was to investigate the presence of hsv type 1 and type 2 in clinical specimens by cell culture, in-house pol ... | 2010 | 20455398 |
| a danish national birth cohort study of maternal hsv-2 antibodies as a risk factor for schizophrenia in their offspring. | several studies have implicated early infections, including maternal infection with herpes simplex virus 2 (hsv-2), as an environmental risk factor for schizophrenia. | 2010 | 20598509 |
| the emerging hiv epidemic among men who have sex with men in tamil nadu, india: geographic diffusion and bisexual concurrency. | in india, men who have sex with men (msm) remain hidden because anal intercourse was criminalized and marriage socially required. we characterize hiv/sti prevalence among msm in tamil nadu. eligible participants were recruited using respondent-driven sampling in eight cities (n = 721). median age was 28, 34% were married and 40% self-identified as homosexual. median number of male partners in the prior year was 15; 45% reported any unprotected anal intercourse (uai). hiv, herpes simplex virus-2 ... | 2010 | 20467890 |
| intimate partner violence, relationship power inequity, and incidence of hiv infection in young women in south africa: a cohort study. | cross-sectional studies have shown that intimate partner violence and gender inequity in relationships are associated with increased prevalence of hiv in women. yet temporal sequence and causality have been questioned, and few hiv prevention programmes address these issues. we assessed whether intimate partner violence and relationship power inequity increase risk of incident hiv infection in south african women. | 2010 | 20557928 |
| incidence of multiple herpesvirus infection in hiv seropositive patients, a big concern for eastern indian scenario. | human immunodeficiency virus (hiv) infection is associated with an increased risk for human herpes viruses (hhvs) and their related diseases and they frequently cause disease deterioration and therapeutic failures. methods for limiting the transmission of hhvs require a better understanding of the incidence and infectivity of oral hhvs in hiv-infected patients. this study was designed to determine the seroprevalence of human herpes viruses (cmv, hsv 2, ebv-1, vzv) antibodies and to evaluate thei ... | 2010 | 20604948 |
| men who have sex with men in the united states: demographic and behavioral characteristics and prevalence of hiv and hsv-2 infection: results from national health and nutrition examination survey 2001-2006. | to describe demographic and behavioral characteristics and the prevalence of hiv and herpes simplex virus type 2 (hsv-2) infections in men who had sex with men identified through a nationally representative, population-based survey. | 2010 | 20473245 |
| chromatin assembly on herpes simplex virus genomes during lytic infection. | the human herpes simplex viruses hsv-1 and hsv-2 infect a significant portion of the human population. both viruses can undergo lytic infection in epithelial cells and establish lifelong latency in neuronal cells. the large hsv-1 dna genomes have long been considered to be devoid of histones both inside the virion particle and inside the cell during lytic infection, but to be packaged in repressive chromatin during latency. however, recent reports indicate that many histone and non-histone chrom ... | 2010 | 19682614 |
| detection of herpes simplex virus dna in plasma of patients with primary but not with recurrent infection: implications for transfusion medicine? | among the family of herpes viruses, only cytomegalovirus (cmv) and, to a lesser extent, human herpes virus 8 (hhv-8) are of relevance in transfusion medicine. due to neutropism, herpes simplex viruses (hsv) types 1 and 2 are considered to be of minor relevance. however, several reports gave evidence that a hsv dnaemia might occur and hsv could therefore be transmissible by blood products. the aim of our study was to collect data about prevalence of hsv antibodies among blood donors and to clarif ... | 2010 | 19708895 |
| perceptions of couple hiv counseling and testing in botswana: a stakeholder analysis. | to explore stakeholder's perceptions of couples hiv counseling and testing (chct) as opposed to individual testing and potential couples' preferences for chct promotion and service provision. | 2010 | 19682831 |
| mechanism of herpes simplex virus type 2 suppression by propolis extracts. | genital herpes caused by herpes simplex virus type 2 (hsv-2) is a chronic, persistent infection spreading efficiently and silently as sexually transmitted disease through the population. antiviral agents currently applied for the treatment of herpesvirus infections include acyclovir and derivatives. aqueous and ethanolic extracts of propolis were phytochemically analysed, different polyphenols, flavonoids and phenylcarboxylic acids were identified as major constituents. the aqueous propolis extr ... | 2010 | 19682876 |
| rapid diagnosis of herpetic encephalitis in children by pcr-microarray technology for simultaneous detection of seven human herpes viruses. | the aim of the study was to evaluate retrospectively the usefulness of polymerase chain reaction (pcr)-microarray technology, which can simultaneously detect seven human herpes viruses for rapid and accurate diagnosis of herpetic encephalitis in children. we simultaneously amplified herpes simplex virus type 1 and type 2 (hsv-1 and hsv-2); varicella-zoster virus; epstein-barr virus (ebv); cytomegalovirus (cmv); and human herpes virus 6 (hhv-6a and hhv-6b) by multiplex pcr, and genotyped by dna m ... | 2010 | 19685343 |
| prevalence and risk factors of human papillomavirus infection by penile site in uncircumcised kenyan men. | human papillomavirus (hpv) prevalence was estimated from 2,705 sexually active, uncircumcised, human immunodeficiency virus seronegative men aged 17-28 years in kisumu, kenya. hpv prevalence was 51.1% (95% confidence interval: 49.2-53.0%) in penile cells from the glans/coronal sulcus and/or shaft. hpv prevalence varied by anatomical site, with 46.5% positivity in the glans/coronal sulcus compared with 19.1% in the shaft (p < 0.0001). high-risk hpv was detected in 31.2% of glans and 12.3% of shaf ... | 2010 | 19626601 |
| brief counseling for reducing sexual risk and bacterial stis among drug users--results from project respect. | project respect's brief risk reduction counseling (brrc) reduced sexual risk and bacterial stis among at-risk heterosexuals and has been packaged for use with this population. we assessed brrc's efficacy with respect participants who used drugs and examined brrc's applicability to present-day users of heroin, cocaine, speedball, or crack. | 2010 | 19720471 |
| the hsv-2 mutant deltapk induces melanoma oncolysis through nonredundant death programs and associated with autophagy and pyroptosis proteins. | malignant melanoma is a highly aggressive and drug-resistant cancer. virotherapy is a novel therapeutic strategy based on cancer cell lysis through selective virus replication. however, its clinical efficacy is modest, apparently related to poor virus replication within the tumors. we report that the growth compromised herpes simplex virus type 2 (hsv-2) mutant, deltapk, has strong oncolytic activity for melanoma largely caused by a mechanism other than replication-induced cell lysis. the ratio ... | 2010 | 19798049 |
| anti-herpetic properties of hydroalcoholic extracts and pressed juice from echinacea pallida. | hydroalcoholic extracts and pressed juice from echinacea pallida were phytochemically characterised by hplc-ms analyses. ferulic and caffeic acid derivatives were identified as major constituents. all tested extracts and pressed juice from echinacea pallida exhibited a low cytotoxic activity on monkey kidney cells in vitro. the inhibitory activity of echinacea against herpes simplex virus types 1 and 2 (hsv-1, hsv-2) was analysed with plaque reduction assays. all hydroalcoholic extracts exhibite ... | 2010 | 19790030 |
| divergence and genotyping of human alpha-herpesviruses: an overview. | herpesviruses are large dna viruses that are highly disseminated among animals. of the eight herpesviruses identified in humans, three are classified into the alpha-herpesvirus subfamily: herpes simplex virus types 1 (hsv-1) and 2 (hsv-2), which are typically associated with mucocutaneous lesions, and varicella-zoster virus (vzv), which is the cause of chicken pox and herpes zoster. all three viruses establish lifelong infections and may also induce more severe symptoms, such as neurological man ... | 2010 | 19772930 |
| the adjuvant cldc increases protection of a herpes simplex type 2 glycoprotein d vaccine in guinea pigs. | herpes simplex virus (hsv) infections are common but there is no vaccine available. we evaluated cationic liposome-dna complexes (cldc) as an adjuvant for an hsv gd2 vaccine and compared it to an mpl/alum adjuvant in a guinea pig model of genital herpes. the addition of cldc to the gd2 vaccine significantly decreased acute and recurrent disease and most importantly the number of days with recurrent virus shedding compared to gd2 alone. reductions in these outcomes were also detected when gd2+cld ... | 2010 | 19857450 |
| increased number and function of natural killer cells in human immunodeficiency virus 1-positive subjects co-infected with herpes simplex virus 2. | natural killer (nk) cells bridge the interface between innate and adaptive immunity and are implicated in the control of herpes simplex virus 2 (hsv-2) infection. in subjects infected with human immunodeficiency virus 1 (hiv-1), the critical impact of the innate immune response on disease progression has recently come into focus. higher numbers of nk cells are associated with lower hiv-1 plasma viraemia. individuals with the compound genotype of killer cell immunoglobulin-like receptor (kir) 3ds ... | 2010 | 19824915 |
| vaccines and microbicides preventing hiv-1, hsv-2, and hpv mucosal transmission. | hiv-1, herpes simplex virus type 2 (hsv-2), and human papillomavirus (hpv), among other sexually transmitted infections, represent a major burden for global health. initial insights into the mucosal transmission of these viral pathogens have raised optimism with regard to the rapid generation of protective vaccines. nevertheless, setbacks for hiv-1 and hsv-2 vaccines have seriously challenged the initial enthusiasm. recently, two new vaccines that efficiently prevented hpv infection have renewed ... | 2010 | 19829304 |
| genital herpes simplex virus type 1 in women: detection in cervicovaginal specimens from gynecological practices in the united states. | herpes simplex virus types 1 and 2 (hsv-1 and -2) are significant human pathogens causing clinically indistinguishable facial and genital lesions. recently, the number of reported genital herpes cases caused by type 1 virus has increased. identifying the hsv type is of clinical importance to determine proper treatment, as there is no licensed vaccine or cure. we assessed, by pcr, the frequency of hsv-1 and hsv-2 present in more than 60,000 clinical cervicovaginal specimens derived from samples o ... | 2010 | 19923487 |
| safety, tolerability, and pharmacokinetics of spl7013 gel (vivagel): a dose ranging, phase i study. | to evaluate safety, tolerability and systemic pharmacokinetics of escalating doses of spl7013 gel in healthy women. | 2010 | 19823111 |
| comparison of focus herpesselect and kalon hsv-2 gg2 elisa serological assays to detect herpes simplex virus type 2 antibodies in a south african population. | sero-epidemiological studies of herpes simplex virus (hsv) type 2 infection in africa remain difficult to interpret as a result of the high rate of false-positive results observed when using the new recombinant gg2 hsv-2 elisa tests. the performance of two widely used gg2 elisa was compared to derive an appropriate testing algorithm for use in south africa. | 2010 | 19837726 |
| hla-drb1*01 allele and low plasma immunoglobulin g1 concentration may predispose to herpes-associated recurrent lymphocytic meningitis. | recurrent lymphocytic meningitis (rlm) is a rare illness caused mostly by herpes simplex virus type 2 (hsv-2). predisposing factors are not known. deficiencies in immunoglobulin (ig) g subclasses 1 (igg1) and 3 (igg3) and complement protein c4 are associated with susceptibility to and persistence of bacterial and viral infections. selected hla and mannose-binding lectin (mbl) alleles have previously been associated with recurrent genital herpes or herpetic meningitis. we assessed the frequencies ... | 2010 | 19879913 |
| bipolar hypertrophic herpes: an unusual presentation of acyclovir-resistant herpes simplex type 2 in a hiv-infected patient. | hypertrophic pseudo tumoral herpetic lesion is an uncommon presentation in immunocompromized hosts that can be refractory to established therapies. we describe bipolar anal and tonsilar herpetic tumoral lesions related to acyclovir-resistant hsv-2 in a human immunodeficiency virus-infected patient. treatment with valacyclovir, cidofovir, and thalidomide failed and surgical excision was required. | 2010 | 19858782 |
| herpes folliculosebaceous ulcer in a patient with chronic lymphocytic leukaemia: an ulcerative variant of herpes folliculitis associated with herpesvirus invasion of folliculosebaceous units in immunocompromised hosts. | 2010 | 19832859 | |
| pregnancy, contraceptive use, and hiv acquisition in hptn 039: relevance for hiv prevention trials among african women. | biomedical hiv prevention trials enroll sexually active women at risk of hiv and often discontinue study product during pregnancy. we assessed risk factors for pregnancy and hiv acquisition, and the effect of pregnancy on time off study drug in hiv prevention trials network 039. | 2010 | 19838129 |
| performance of hsv-2 type specific serological tests in men in kenya. | this study compared five serological tests with western blot from university of washington to determine the most accurate method for detecting antibodies to herpes simplex virus type 2 (hsv-2) in a male population in kisumu, kenya. a random sample of 250 fishermen from 18 beaches along lake victoria underwent serological testing by two generations of the herpeselect hsv-2 elisa ("focus gen 1" and "focus gen 2"), kalon hsv-2 elisa ("kalon"), biokit hsv-2 rapid test ("biokit"), and herpeselect exp ... | 2010 | 19854222 |
| polyradiculoneuropathy associated to human herpesvirus 2 in an hiv-1-infected patient (elsberg syndrome): case report and literature review. | peripheral nerve disorders are a common complication in hiv patients, reaching 15% of them. several patterns and aetiologies have been described, being lumbosacral poliradiculoneuropathy one of them. we describe an hiv-1-infected patient who developed lumbosacral poliradiculoneuropathy caused by human herpesvirus 2 and review the literature about this uncommon condition. | 2010 | 19858783 |
| evaluation of three multiplex flow immunoassays compared to an enzyme immunoassay for the detection and differentiation of igg class antibodies to herpes simplex virus types 1 and 2. | the diagnosis of herpes simplex virus (hsv) infections is routinely made based on clinical findings and supported by laboratory testing using pcr or viral culture. however, in instances of subclinical or unrecognized hsv infection, serologic testing for igg class antibodies to type-specific hsv glycoprotein g (gg) may be useful. this study evaluated and compared the performances of three multiplex flow immunoassays (athena multi-lyte [zeus scientific], bioplex 2200 [bio-rad laboratories], and pl ... | 2010 | 20007366 |
| medical application of herpes simplex virus. | herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) are important human pathogens that cause a variety of diseases from mild skin diseases such as herpes labialis and herpes genitalis to life-threatening diseases such as herpes encephalitis and neonatal herpes. a number of studies have elucidated the roles of this virus in viral replication and pathogenicity, the regulation of gene expression, interaction with the host cell and immune evasion from the host system. this research has allowed th ... | 2010 | 19939634 |
| skin disease among human immunodeficiency virus-infected adolescents in zimbabwe: a strong indicator of underlying hiv infection. | southern africa is witnessing the emergence of an epidemic of long-term survivors of vertically acquired human immunodeficiency virus (hiv) infection presenting with untreated hiv as adolescents. dermatologic conditions, common in both hiv-infected adults and children, have not been described in this age-group. we investigated the prevalence and spectrum of skin conditions in adolescents admitted to hospitals in zimbabwe. | 2010 | 19940800 |
| identification of viral micrornas expressed in human sacral ganglia latently infected with herpes simplex virus 2. | deep sequencing of small rnas isolated from human sacral ganglia latently infected with herpes simplex virus 2 (hsv-2) was used to identify hsv-2 micrornas (mirnas) expressed during latent infection. this effort resulted in the identification of five distinct hsv-2 mirna species, two of which, mir-h3/mir-i and mir-h4/mir-ii, have been previously reported. three novel hsv-2 mirnas were also identified, and two of these, mir-h7 and mir-h9, are derived from the latency-associated transcript (lat) a ... | 2010 | 19889786 |
| herpes simplex virus (hsv)-specific t cells activated in the absence of ifn-gamma express alternative effector functions but are not protective against genital hsv-2 infection. | interferon gamma (ifngamma) is important for immune resistance to herpes simplex virus (hsv) infection. to examine the influence of ifngamma on the development of hsv-specific immune responses and test for ifngamma-independent adaptive immune mechanisms of protection, ifngamma-deficient mice (ifngamma(-/-)) were immunized with thymidine kinase-deficient hsv-2 (hsv-2 333tk(-)). hsv-specific cellular and humoral responses were elicited in immunized ifngamma(-/-) mice resulting in increased resista ... | 2010 | 19942296 |
| construction and immune response of hsv-2gd-hsp70 dna vaccine. | 2010 | 19942410 | |
| intranasal immunization with a proteoliposome-derived cochleate containing recombinant gd protein confers protective immunity against genital herpes in mice. | the purpose of this study was to investigate the potential of intranasal (in) immunization with neisseria meningitides b proteoliposome (afpl1) and afpl1-derived cochleate (afco1), containing glycoprotein d (gd) of herpes simplex virus type 2 (hsv-2) for induction of protective immunity against genital herpes infection in mice. we could show that in immunization with both afpl1 and afco1 containing gd induced gd-specific igg antibody and lymphoproliferative responses. however, ifn-gamma response ... | 2010 | 19945418 |
| multi-targeted neuroprotection by the hsv-2 gene icp10pk includes robust bystander activity through pi3-k/akt and/or mek/erk-dependent neuronal release of vascular endothelial growth factor and fractalkine. | hippocampal cultures infected with the deltarr vector for the hsv-2 anti-apoptotic gene icp10pk survive cell death triggered by a wide variety of insults. survival includes robust protection of uninfected neurons, but the mechanism of this bystander activity is still unclear. here we report that icp10pk+ neurons release soluble factors that protect uninfected neurons from nmda and mpp+-induced apoptosis. release depends on icp10pk-mediated activation of the ras signaling pathways mek/erk and pi3 ... | 2010 | 19891735 |
| etiology and determinants of sexually transmitted infections in karnataka state, south india. | syndromic case management remains the cornerstone for sti (sexually transmitted infection) treatment in many countries. we undertook this study to better understand the etiology of stis in adults in south india and to inform sti management guidelines. | 2010 | 19901864 |
| the association between lack of circumcision and hiv, hsv-2, and other sexually transmitted infections among men who have sex with men. | observational studies evaluating the association of circumcision and hiv infection among men who have sex with men (msm) have yielded mixed results. we examined the relationship between circumcision and hiv, herpes simplex virus type-2 (hsv-2), syphilis, urethral gonorrhea, and urethral chlamydia among msm stratified by anal sexual role. | 2010 | 19901865 |
| synthesis and antiviral activity of scopadulane-rearranged diterpenes. | a new bioactive diterpene skeleton resulting from a backbone rearrangement is described. activity of the rearranged product and several derivatives against herpes virus simplex type 2 is reported. | 2010 | 20064563 |
| analysis of filamentous process induction and nuclear localization properties of the hsv-2 serine/threonine kinase us3. | the us3 serine/threonine kinase encoded by all alphaherpesviruses performs several important functions during virus multiplication. for example, expression of pseudorabies virus (prv) us3 causes reorganization of the actin cytoskeleton into filamentous processes (fps) that promote cell-to-cell spread of virus infection. prv us3-induced fp formation requires us3 kinase activity. to determine whether these characteristics were shared by hsv-2 us3, expression plasmids for wild type (wt) and kinase ... | 2010 | 19945726 |
| fatal herpes virus type i infection in a newborn. | the authors present a case of environmentally acquired fatal herpes virus type i infection in a newborn after cesarean section and a discussion of the clinical presentation, pathogenesis and diagnosis of herpes simplex type i (hsv-1) at autopsy. herpes simplex virus, both type i and type ii, are well described infectious agents in newborns. though herpes simplex type ii (hsv-2) is commonly associated with fatal neonatal infections, it is important to consider hsv-1 to make the correct diagnosis. ... | 2010 | 19949315 |
| recent syphilis infection prevalence and risk factors among male low-income populations in coastal peruvian cities. | the objective of this study was to examine the epidemiology of syphilis among high-risk socially marginalized populations in urban, coastal peru, to quantify the prevalence of recent syphilis infection and identify risk factors. | 2010 | 19940809 |
| a new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2. | human immunodeficiency virus type 1 (hiv-1) and herpes simplex virus type 2 (hsv-2) are responsible for 2 intersecting epidemics in which the disease caused by 1 virus facilitates the transmission of and pathogenesis by the other. therefore, suppression of one virus infection will affect the other. acyclovir, a common antiherpetic drug, was shown to directly suppress both viruses in coinfected tissues. however, both antiviral activities of acyclovir are dependent on phosphorylation by the nucleo ... | 2010 | 20085496 |
| type-specific herpes simplex virus-1 and herpes simplex virus-2 seroprevalence in romania: comparison of prevalence and risk factors in women and men. | to determine herpes simplex virus (hsv)-2 and hsv-1 seroprevalence in women and men in romania. | 2010 | 20106695 |
| postcoital bioavailability and antiviral activity of 0.5% pro 2000 gel: implications for future microbicide clinical trials. | the pharmacokinetics and pharmacodynamics of vaginal microbicides are typically assessed among sexually abstinent women. however, the physical act of sex may modulate gel distribution, and preclinical studies demonstrate seminal plasma interferes with the antiviral activity of several microbicides. this study compared the biological activity and concentration of pro 2000 in cervicovaginal lavage (cvl) collected in the absence or following coitus. | 2010 | 20107502 |
| hiv-1 and stis prevalence and risk factors of miners in mining districts of yunnan, china. | to assess hiv/sexually transmitted infection (sti) prevalence and associated risk factors among miners in yunnan, china. | 2010 | 20104111 |
| construction and properties of a herpes simplex virus 2 dl5-29 vaccine candidate strain encoding an hsv-1 virion host shutoff protein. | the replication-defective herpes simplex virus 2 (hsv-2) dl5-29 mutant virus strain with deletions in the u(l)5 and u(l)29 genes has been shown to protect mice and guinea pigs against challenge with wild-type (wt) hsv-2 and to protect against ocular disease caused by hsv-1 infection. the dl5-29 strain is currently being prepared for clinical trials as a herpes vaccine candidate. as a possible approach to improve the efficacy of dl5-29 as a genital herpes vaccine, we replaced the u(l)41 gene enco ... | 2010 | 20117270 |
| female genital tract secretions inhibit herpes simplex virus infection: correlation with soluble mucosal immune mediators and impact of hormonal contraception. | female genital tract secretions inhibit herpes simplex virus (hsv) infection, however, the intra- and inter-subject variability, contribution of specific mediators, and impact of reproductive hormones have not been defined. | 2010 | 20015330 |
| low prevalence of varicella zoster virus and herpes simplex virus type 2 in saliva from human immunodeficiency virus-infected persons in the era of highly active antiretroviral therapy. | human herpesviruses, e.g., herpes simplex virus (hsv) type 1, epstein-barr virus, and cytomegalovirus, appear in saliva at greater frequency in persons infected with human immunodeficiency virus (hiv) than in healthy individuals. however, it is not known if varicella zoster virus (vzv) and hsv-2 appear simultaneously during hiv infection at greater frequency in saliva in this era of highly active antiretroviral therapy (haart). the aim of this study was to investigate the prevalence and amounts ... | 2010 | 20123407 |
| xylans from scinaia hatei: structural features, sulfation and anti-hsv activity. | natural compounds offer interesting pharmacological perspectives for antiviral drug development with regard to broad-spectrum antiviral properties and novel modes of action. in this study, we have analyzed alkali-extracted xylan of scinaia hatei. alkali extraction of this red alga yielded a xylan shown to have a molecular mass of 120kda and a linear structure of (1-->4)-linked beta-d-xylopyranosyl residues. derivatives (s1, s2, s3 and s4) generated by chemical sulfation from this macromolecule h ... | 2010 | 20026104 |
| toll-like receptor-mediated recognition of herpes simplex virus. | herpes simplex virus type 1 and 2 (hsv-1 and hsv-2, respectively) are two important human pathogens that belong to the genus simplex within the subfamily alpha of the herpesvirinae. toll-like receptors (tlrs) constitute a family of conserved sensors that play a prominent role during the early anti-viral response, including that against herpesviruses. although substantial progress has been made, central questions remain to be solved to figure out how tlrs modulate viral pathogenesis. the aim of t ... | 2010 | 20036979 |
| herpes simplex virus type-2 in egyptian patients with bladder cancer or cystitis. | the present study was designed to investigate the prevalence of herpes simplex virus type-2 (hsv-2) in egyptian patients with bladder cancer or cystitis and to evaluate the performance of different diagnostic hsv-2 assays. the study included 50 patients: 27 with bladder cancer (group i), 23 with cystitis (group ii) and 20 subjects as controls (group iii). hsv-2 dna was detected using polymerase chain reaction (pcr) on bladder tissue and buffy coat cells (bcc). electron microscopic studies (ems) ... | 2010 | 20041869 |
| male circumcision for the prevention of acquisition and transmission of sexually transmitted infections: the case for neonatal circumcision. | the american academy of pediatrics (aap) male circumcision policy states that while there are potential medical benefits of newborn male circumcision, the data are insufficient to recommend routine neonatal circumcision. since 2005, however, 3 randomized trials have evaluated male circumcision for prevention of sexually transmitted infections. the trials found that circumcision decreases human immunodeficiency virus acquisition by 53% to 60%, herpes simplex virus type 2 acquisition by 28% to 34% ... | 2010 | 20048246 |
| simian trim5alpha proteins reduce replication of herpes simplex virus. | old world monkey trim5alpha proteins are known to block the replication of human immunodeficiency virus and other retroviruses in a species-specific fashion. in this report, we show that specific forms of simian trim5alpha proteins can restrict herpes simplex virus (hsv) infection. to define the effect of trim5alpha on hsv replication, we examined hsv infection in hela cell lines that stably express simian and human orthologs of trim5alpha proteins. we demonstrated that several simian trim5alpha ... | 2010 | 20060996 |
| critical issues related to porcine xenograft exposure to human viruses: lessons from allotransplantation. | xenotransplantation of tissues from swine into humans poses the threat of bidirectional transfer of porcine or human microorganisms to the recipient or to the xenograft, respectively. this review focuses on recipient-derived infection. recent data are reviewed that assess the susceptibility of porcine cells to human viruses. on the basis of the experience in allotransplantation, potential consequences for the xenograft are discussed. | 2010 | 20061950 |
| the prevalence, incidence and risk factors of herpes simplex virus type 2 infection among pregnant zimbabwean women followed up nine months after childbirth. | herpes simplex virus type 2 (hsv-2) is the leading cause of genital ulcer disease worldwide. the virus can be transmitted to neonates and there are scarce data regarding incidence of hsv-2 among women in pregnancy and after childbirth. the aim of this study is to measure the incidence and risk factors for hsv-2 infection in women followed for 9 months after childbirth. | 2010 | 20064273 |
| sensitivity of v75i hiv-1 reverse transcriptase mutant selected in vitro by acyclovir to anti-hiv drugs. | trials of acyclovir for herpes simplex virus 2 infection in herpes simplex virus 2/hiv-1 coinfected patients not on antiretroviral therapy demonstrated a decrease in herpes simplex virus 2 and hiv-1 replication. recent studies indicated that acyclovir has direct anti-hiv-1 activity and can select for the hiv-1 v75i reverse transcriptase variant in vitro. we show that the v75i variant has decreased sensitivity to some nucleoside analogs but an increased sensitivity to zidovudine, results that may ... | 2010 | 20009920 |
| estradiol limits viral replication following intravaginal immunization leading to diminished mucosal igg response and non-sterile protection against genital herpes challenge. | previously we reported that ovariectomized (ovx) mice receiving estradiol (e) prior to immunization with an attenuated strain of hsv-2 (tk-hsv-2) were not protected. lack of protection in the e group was because of the inability of tk-hsv-2 to penetrate the thick keratinized epithelium. in this study, we determined the outcome of immunization after the thickening of vaginal epithelium following e-treatment waned. ovx, c57bl/6 mice were given progesterone (p), e or saline (s) for 3 days and immun ... | 2010 | 20070285 |
| prevalence of sexually transmitted diseases and risk behaviors from the nimh collaborative hiv/std prevention trial. | this cross-sectional study describes the baseline prevalence and correlates of common bacterial and viral sexually transmitted diseases (stds) and risk behaviors among individuals at high risk for hiv recruited in five low- and middle-income countries. correlations of risk behaviors and demographic factors with prevalent stds and the association of stds with hiv prevalence are examined. between 2,212 and 5,543 participants were recruited in each of five countries (china, india, peru, russia, and ... | 2010 | 25400718 |
| pattern of sexually transmitted infections and performance of syndromic management against etiological diagnosis in patients attending the sexually transmitted infection clinic of a tertiary care hospital. | the availability of baseline information on the epidemiology of sexually transmitted infections (stis) and other associated risk behaviors is essential for designing, implementing, and monitoring successful targeted interventions. also, continuous analysis of risk assessment and prevalence-based screening studies are necessary to evaluate and monitor the performance of syndromic management. the aim of the present study was to document the pattern of common stis and to evaluate the performance of ... | 2010 | 21716796 |
| screening of herpes simplex virus 2 infection among pregnant women in southern china. | the aim was to investigate the prevalence of herpes simplex virus (hsv)-2 infection among pregnant women in southern china and analyze the relationship between the hsv-2 infection and pregnancy outcome. we examined 1740 sera collected from pregnant women aged 21-39 years, using enzyme-linked immunosorbent assay for the detection of specific antibodies against hsv-2. the overall prevalence of hsv-2 infection was 23.56% (95% confidence interval [ci]=21.53-26.00). the prevalence of hsv-2 infection ... | 2010 | 21269306 |
| [antiviral activity of aqueous extracts and polysaccharide fractions from mycelium and fruit bodies of higher fungi]. | sixty preparations of basidiomycetes (ganoderma, lentinus, pleurotus, laetiporus, polyporus, inonotus, flammulina, grifola, trametes) were investigated with respect to their toxicity for vero cells and antiviral activity. the antiviral activity was estimated with the use of the west nile virus and type 2 herpes simplex. it was shown that 11 preparations of ganoderma, lentinus and pleurotus completely inhibited the infective activity in doses not lower than 1000 tcd50 (the west nile virus) and 10 ... | 2010 | 21400748 |
| synthesis and early development of hexadecyloxypropylcidofovir: an oral antipoxvirus nucleoside phosphonate. | hexadecyloxypropyl-cidofovir (hdp-cdv) is a novel ether lipid conjugate of (s)-1-(3-hydroxy-2-phosphonoylmethoxypropyl)-cytosine (cdv) which exhibits a remarkable increase in antiviral activity against orthopoxviruses compared with cdv. in contrast to cdv, hdp-cdv is orally active and lacks the nephrotoxicity of cdv itself. increased oral bioavailability and increased cellular uptake is facilitated by the lipid portion of the molecule which is responsible for the improved activity profile. the l ... | 2010 | 21994617 |
| fishermen as a suitable population for hiv intervention trials. | background. suitable populations to sustain continued evaluation of hiv and sexually transmitted infection (sti) prevention interventions are required. we sought to determine whether fishermen are a suitable population for hiv intervention trials. methods. in a cross-sectional descriptive survey, we selected 250 fishermen from proportional to size sampled boats. we collected socioeconomic and behavioral information, and specimens for hiv, herpes simplex virus (hsv-2), syphilis, gonorrhea, chlamy ... | 2010 | 21490906 |
| hsv-2 serology can be predictive of hiv epidemic potential and hidden sexual risk behavior in the middle east and north africa. | hiv prevalence is low in the middle east and north africa (mena) region, though the risk or potential for further spread in the future is not well understood. behavioral surveys are limited in this region and when available have serious limitations in assessing the risk of hiv acquisition. we demonstrate the potential use of herpes simplex virus-2 (hsv-2) seroprevalence as a marker for hiv risk within mena. | 2010 | 21352788 |