Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [genetic markers of herpes simplex virus. 2. study of genetic markers of the us strain of herpes simplex virus of the 3d antigenic group]. | 1970 | 4319413 | |
| chronic infections by herpes simplex viruses and by the horse and cat herpesviruses. | rabbit eyes experimentally infected with either type 1 or type 2 herpes simplex viruses occasionally released virus spontaneously. injection of adrenalin was not highly effective for stimulating virus release but did seem to have a slight and erratic activating capacity. no spontaneous virus release were detected from the eyes of six cats infected with cat herpesvirus, but, when adrenalin was administered, an episode of virus release did ensue in one animal. rabbit spinal cords could be chronica ... | 1970 | 16557741 |
| differential effect of 7,12-dimethylbenz(a)anthracene on infectivity of herpes simplex virus type 2. | 1971 | 4322268 | |
| oncogenic transformation of hamster cells after exposure to herpes simplex virus type 2. | 1971 | 4329350 | |
| size, composition, and structure of the deoxyribonucleic acid of herpes simplex virus subtypes 1 and 2. | studies of the size, composition, and structure of the deoxyribonucleic acid (dna) of the f and g prototypes of herpes simplex virus (hsv) subtypes 1 and 2 (hsv-1 and hsv-2) showed the following. (i) as previously reported by good-heart et al. hsv-1 and hsv-2 dna have a buoyant density of 1.726 and 1.728 g/cm(3), corresponding to 67 and 69 guanine +/- cytosine moles per cent, respectively. the difference in guanine plus cytosine content of the dna species was confirmed by the finding of a 1 c di ... | 1971 | 4329966 |
| temperature-sensitive mutants of herpes simplex virus type 2. | 1971 | 4333719 | |
| synergistic effect of herpes simplex virus and cytosine arabinoside on human chromosomes. | the combined treatment of cultures of human embryonic lung cells with herpes simplex virus type 2 and cytosine arabinoside produced a significantly increased number of cells containing multiple chromatid and chromosome breaks. the incidence of such cells was found to be approximately two and one half times greater than the additive effects of virus and cytosine arabinoside induced separately and is therefore synergistic. | 1971 | 4104257 |
| properties of hamster embryo fibroblasts transformed in vitro after exposure to ultraviolet-irradiated herpes simplex virus type 2. | an in vitro method which led to the transformation of hamster embryo fibroblasts after exposure to herpes simplex virus type 2 (hsv-2) inactivated with ultraviolet irradiation is described. the transformed cells (333-8-9) produced tumors when inoculated into newborn syrian hamsters but not when injected into weanling syrian hamsters of the same lsh inbred strain. however, after one in vivo passage, the 333-8-9 cells became highly oncogenic in weanling hamsters. no infectious virus was recovered ... | 1971 | 4108570 |
| absence of leukosis virus markers in hamster cells transformed by herpes simplex virus type 2. | hamster cells which transformed after exposure to herpes simplex virus type 2 previously irradiated with ultraviolet light were tested for the presence of hamster leukosis viruses or their virus-specific antigens. three techniques that were used did not detect the presence of either hamster c-type particles or antigens commonly associated with such structures. the implication of these findings to current concepts of virus oncology is discussed. | 1972 | 4113887 |
| susceptibility of herpesviruses to cytosine arabinoside: standardization of susceptibility test procedure and relative resistance of herpes simplex type 2 strains. | susceptibility testing of herpes simplex type 1 (hsv-1) and type 2 (hsv-2) viruses to cytosine arabinoside (ara-c) has been standardized under conditions of optimal reproducibility, susceptibility, and simplicity. standard conditions were defined as virus inoculum of 10(1.5) to 10(2.5) tcid(50), wi-38 strain of lung fibroblasts, 2-day incubation, and observation of virus cytopathic effect after staining by the may-greenwald-giemsa method. the variability of minimum inhibitory concentration (mic) ... | 1972 | 4364937 |
| genetic relatedness of type 1 and type 2 herpes simplex viruses. | the extent of homology between herpes simplex virus(1) and(2) (hsv-1 and hsv-2) deoxyribonucleic acid (dna) was measured in two ways: (i) by determination of the relative rate of hybridization of labeled hsv-1 and hsv-2 dna to excess unlabeled hsv-1 or hsv-2 dna immobilized on filters and (ii) by determination of the rate of hybridization of labeled hsv-1 and hsv-2 dna to excess unlabeled hsv-1 or hsv-2 dna in solution. approximately 40% of hsv-1 and hsv-2 dna is homologous at hybridization temp ... | 1972 | 4337161 |
| mechanism of the restricted growth of herpes simplex virus type 2 in a hamster cell line. | 1972 | 4342820 | |
| proteins specified by herpes simplex virus. 8. characterization and composition of multiple capsid forms of subtypes 1 and 2. | two classes of herpesvirus capsids, designated a and b, were isolated from the nuclei of human cells infected with herpes simplex virus (hsv). a and b capsids share in common four structural proteins, i.e., no. 5, 19, 23, and 24. b capsids contain 7.7 to 9.7 times more deoxyribonucleic acid than a capsids; moreover, they contain proteins no. 21 and 22a in addition. all of the proteins contained in the capsid except no. 22a are present in the enveloped nucleocapsids (virions) in approximately the ... | 1972 | 4344252 |
| [herpes simplex virus type 2: its distribution and relationship to cervical carcinoma]. | 1972 | 4344976 | |
| ultrastructural characterization of hamster cells transformed following exposure to ultraviolet-irradiated herpes simplex virus type 2. | 1972 | 4345407 | |
| increasing antibody titers to herpes simplex virus type 2 during follow-up of women with cervical dysplasia. | 1973 | 4347508 | |
| immunologic manipulation of metastases due to herpesvirus transformed cells. | herpes simplex virus type 1 (hsv-1), type 2 (hsv-2), and simian virus 40 (sv40) fail to induce immunity in weanling syrian hamsters to transplant of hamster cells transformed by hsv-2. however, the development of metastatic tumors is markedly enhanced by prior immunization with hsv-1. immunization with sv40, ultraviolet-irradiated tumor cells, or ultraviolet-irradiated normal hamster embryo cells inhibits the development of metastases. the hsv-hamster system appears a good one for the study of d ... | 1973 | 4347994 |
| different patterns of neurologic involvement with herpes simplex virus types 1 and 2: isolation of herpes simplex virus type 2 from the buffy coat of two adults with meningitis. | 1973 | 4348495 | |
| incidence of antibody to envelope antigen of herpes simplex virus type 2 among patients with cervical carcinoma and matched controls. | 1973 | 4350521 | |
| rna synthesis in cells infected with herpes simplex virus. vii. control of transcription and of transcript abundancies of unique and common sequences of herpes simplex virus 1 and 2. | analysis of the kinetics of hybridization in liquid of labeled herpes simplex virus (hsv) 1 and 2 dnas with excess unlabeled rna extracted at 2 (early) and 8 (late) h postinfection revealed the following. (i) the rna transcripts present in the hsv-1-infected cells at 2 and 8 h postinfection are complementary to 44 and 48% of hsv-1 dna. the rna transcripts present in the hsv-2-infected cells at 2 and 8 h postinfection are complementary to 21 and 50% of hsv-2 dna. (ii) the transcripts present in 2 ... | 1973 | 4351458 |
| characterisation of temperature-sensitive mutants of herpes simplex virus type 2. growth and dna synthesis. | 1973 | 4351614 | |
| herpes simplex virus type 2 in acute aseptic meningitis. | 1973 | 4351624 | |
| nonvirion antigens produced by herpes simplex viruses 1 and 2. | of nine herpes simplex virus 1 strains (from lip, mouth, throat, cornea, or brain) only five produced enough nonvirion antigen (i.e., not a structural component of the virus) to be detected by complement fixation with specially prepared, virion-absorbed, type-1 guinea pig antisera, while the remaining four strains produced only enough of the same antigen to induce specific antibody in hyperimmunized guinea pigs. while the type 1 virion antiserum used reacted equally well by complement fixation w ... | 1973 | 4352219 |
| nucleic acid hybridization and the relationship between cervical cancer and herpes simplex virus type 2. | 1973 | 4352394 | |
| hexagonal arrangement of filaments in herpes simplex virus type 2-infected cells. | 1973 | 4353342 | |
| infection with herpes-simplex viruses 1 and 2. ii. | herpes-simplex virus 1 (hsv1) and 2 can cause recurrent infection in man and in nonhuman species localized on a specific area of the body, such as face, cornea, or genitals. the origin of the virus responsible for a recurrent infection is not usually apparent. some possible sources of virus can be exogenous infection, endogenous infection from another site of the body, chronic, continuous viral multiplication around the site of involvement, and persistence of the virus at the site of the recur ... | 1973 | 4353782 |
| [relationship between herpes simplex virus type 2 and carcinoma of the uterine cervix]. | 1973 | 4354419 | |
| oncogenic transformation of hamster embryo cells after exposure to inactivated herpes simplex virus type 1. | the in vitro transformation of hamster embryo fibroblasts by herpes simplex virus type 1 (hsv-1) after exposure of the virus to uv irradiation is described. cell transformation was induced by 2 out of 12 strains of hsv-1 that were tested for transforming potential. cells transformed by the kos strain of hsv-1 were not oncogenic when injected into newborn syrian hamsters. however, cells transformed by hsv-1 strain 14-012 induced tumors in 47% of the newborn hamsters injected. hsv-specific antigen ... | 1973 | 4355928 |
| herpes simplex meningitis: isolation of herpes simplex virus type 2 from cerebrospinal fluid. | 1973 | 4356148 | |
| infection, haemorrhage and death of chick embryos after inoculation of herpes simplex virus type 2 on to the chorioallantoic membrane. | 1973 | 4357372 | |
| development of cell lines after exposure of chicken embryonic fibroblasts to herpes simplex virus type 2 at supraoptimal temperature. | 1973 | 4359668 | |
| resistance of hamster cells transformed by herpes simplex virus type 2 to superinfection by herpes simplex viruses. | 1973 | 4359758 | |
| treatment of herpes simplex virus types 1 and 2 encephalitis in mice with 9-beta-d-arabinofuranosyladenine. | the susceptibility of herpes simplex type 1 and type 2 viruses to 9-beta-d-arabinofuranosyladenine (ara-a) was tested in intracerebrally infected mice. subcutaneously administered ara-a resulted in markedly equivalent and reproducible chemotherapeutic activity against both serotypes of herpes simplex viruses. administration of ara-a by several different intermittent dosage regimens showed that change in pattern of response in terms of survivors appears to be influenced more by total amount of dr ... | 1973 | 4790577 |
| herpes simplex and herpes genitalis viruses in etiology of some human cancers. | the results of complement fixation tests on 202 sera from people without cancer and from patients with cancer in 29 different areas of the body indicated that only those with nine varieties of advanced cancer (lip, mouth, oropharynx, nasopharynx, kidney, urinary bladder, prostate, cervix uteri, and vulva-all of 56 tested) gave positive specific reactions with nonvirion antigens induced by the dna herpes simplex (hsv 1) and herpes genitalis (hsv 2) viruses. none of 57 people without cancer (inclu ... | 1973 | 4361685 |
| [modern views concerning the part played by herpes simplex type 2 virus in the pathogenesis of cancer of the cervix]. | recent views on the relationship between carcinoma of the cervix and the herpes virus are presented. while the question is still very open, it can nervetheless be suggested that the type 2 virus plays a part in the pathogenesis of the tumour. sexual relationships, pregnancy and hormones are important factors in this connection. | 1973 | 17343163 |
| assessment of cytosine arabinoside as an antiviral agent in humans. | cytotoxicity, minimal inhibitory concentrations of herpesviruses, and pharmacokinetic studies of cytosine arabinoside (ara-c) were done. ara-c compared favorably with idoxuridine in in vitro studies of antiviral activity versus herpes simplex, varicella-zoster, and cytomegalovirus. however, ara-c was 10 times more toxic to tissue cultures, and concentrations in serum and urine of three patients who were given ara-c at acceptable dosages (1 mg/kg per day) were not measurable by our assay. these s ... | 1974 | 15825312 |
| in vitro antiviral activity of 6-substituted 9-beta-d-ribofuranosylpurine 3', 5'-cyclic phosphates. | a series of twelve recently synthesized 6-substituted derivatives of 9-beta-d-ribofuranosylpurine 3',5'-cyclic phosphate (rpcmp) were evaluated for in vitro antiviral activity, using inhibition of viral cytopathogenic effect as the primary parameter for evaluation. inhibition of the development of intra- and extracellular virus titer was used as a secondary criterion with certain viruses. five derivatives were considered to have significant antiviral activity. 6-hydroxylamino-rpcmp was active ag ... | 1974 | 15825420 |
| study on the propagation of herpes simplex virus (type 2) into the brain after intraocular injection. | 1974 | 4362812 | |
| activation of herpes specific antigens and infectious virus in a hamster cell line transformed by hsv-2. | 1974 | 4363046 | |
| persistence and expression of the herpes simplex virus type 2 genome in cervical tumor cells. | 1974 | 4363067 | |
| latent ganglionic infection with herpes simplex virus types 1 and 2: viral reactivation in vivo after neurectomy. | inoculation of the cornea, lip, or footpad of mice with herpes simplex virus type 1 resulted in a latent infection of the local sensory ganglia. inoculation of the vagina and cervix with herpes simplex virus type 2, as well as type 1, also induced a latent ganglionic infection. with the use of sciatic nerve section as a stimulus, a reproducible model of viral reactivation in vivo was established. | 1974 | 4364361 |
| inactivation of herpes simplex virus by concanavalin a. | the infectivity of herpes simplex virus type 1 (hsv-1) was inactivated after treatment with either concanavalin a (cona) or periodate. phytohemagglutinin, wheat germ agglutinin, pokeweed mitogen, and neuraminidase failed to inactivate the virus. the effect of cona could be specifically inhibited or reversed by the addition of alpha-methyl-d-glucoside or alpha-methyl-d-mannoside. evidence was obtained that hsv-1 inactivated by cona could adsorb to host cells. viral aggregation was not a major mec ... | 1974 | 4364903 |
| isolation, complementation and preliminary phenotypic characterization of temperature-sensitive mutants of herpes simplex virus type 2. | 1974 | 4361460 | |
| inhibition of herpes simplex virus type 2 replication by thymidine. | replication of herpes simplex virus type 2 (hsv-2) was impeded in kb cells which were blocked in their capacity to synthesize dna by 2 mm thymidine (tdr). the degree of inhibition was dependent upon the concentration of tdr. in marked contrast, hsv-1 is able to replicate under these conditions. the failure of hsv-2 to replicate is probably due to the inhibition of viral dna synthesis; there was a marked reduction in the rate of dna synthesis as well as the total amount of hsv-2 dna made in the p ... | 1974 | 4365718 |
| epidemiological studies relating genital herpetic infection to cervical carcinoma. | epidemiological studies relating genital herpetic infection to cervical carcinoma are reviewed. the high frequency of herpes simplex virus type 2 (hsv-2) antibodies in young women (21 years or younger) with cervical carcinoma in situ and in women with dysplasia or carcinoma in situ, matched for various sexual attributes to control women, provide support for a causal relation. however, various laboratory, histopathological, and statistical problems associated with all epidemiological studies do ... | 1974 | 4366985 |
| a nonhuman primate model for the study of the cervical oncogenic potential of herpes simplex virus type 2. | 1974 | 4366986 | |
| biochemical approaches to detection of herpes simplex virus type 2 in cervical carcinoma. | 1974 | 4366987 | |
| persistence and expression of the herpes simplex virus type 2 genome in cervical tumor cells. | 1974 | 4367156 | |
| transformation of hamster embryo and human embryo cells by temperature sensitive mutants of herpes simplex virus type 2. | 1974 | 4370516 | |
| expression of the viral thymidine kinase gene in herpes simplex virus-transformed l cells. | in these studies, the expression of thymidine kinase (tk) in normal and herpes simplex virus (hsv)-transformed l cells has been compared. in asynchronously dividing cultures of l cells, the tk activity rose and declined rapidly and coordinately with dna synthesis. when net cell increase stopped, tk activity was at a minimum. in contrast, tk activity of hsv-transformed cells remained at a minimum during rapid dna synthesis and gradually increased as the rate of dna synthesis decreased. when net c ... | 1974 | 4372394 |
| the "viruses of love" and cancer. | a review of recent results of research into herpesvirus is presented and a tentative association with cervical cancer is proposed. 2 types of the virus have been identified, hsv-1 which causes fever blisters or lip sores and hsv-2 which causes genital lesions. the structure and composition of the virus is described. in addition, mechanisms of productive and nonproductive infection at the cellular level are reviewed. the pathogenesis of the hsv-1 and hsv-2 infections varies according to previ ... | 1974 | 4372887 |
| effect of dexamethasone on herpes simplex virus type 2 infection in vitro. | 1974 | 4373659 | |
| enhanced replication of temperature-sensitive mutants of herpes simplex virus type 2 (hsv-2) at the nonpermissive temperature in cells transformed by hsv-2. | 1974 | 4374446 | |
| virus type-specific thymidine kinase in cells biochemically transformed by herpes simplex virus types 1 and 2. | transformation of mouse cells (ltk(-)) and human cells (hela bu) from a thymidine kinase (tk)-minus to a tk(+) phenotype (herpes simplex virus [hsv]-transformed cells) has been induced by infection with ultraviolet-irradiated hsv type 2 (hsv-2), as well as by hsv type 1 (hsv-1). medium containing methotrexate, thymidine, adenine, guanosine, and glycine was used to select for cells able to utilize exogenous thymidine. we have determined the kinetics of thermal inactivation of tk from cells lytica ... | 1974 | 4359421 |
| cervical cancer epidemiology in historical perspective. | in 1846, uterine cancer was the most frequently observed malignant tumor in western europe. it accounted for nearly 1/3 of all reported deaths in paris. the cervix was regarded as the primary source in most cases. several etiological theories in vogue today were discussed then. the relative infrequency of cervical cancer among jewish women was reported by numerous writers. the possible role of circumcision of husbands was not seriously considered until 1935. more recent such studies have been in ... | 1974 | 4599289 |
| potentiation of an adenovirus-associated virus by herpes simplex virus type-2-transformed cells. | the herpes simplex virus type-2 (hsv-2)-transformed cell line 333-8-9 was inoculated with adeno-virus-associated virus type 3 (aav-3) and examined by immunofluorescent (fa) techniques for evidence of aav-3 antigen synthesis. antisera prepared against the three sodium dodecyl sulfate-dissociated structural polypeptides (vp-1, vp-2, and vp-3) of aav-3 and against the whole aav-3 virion were used as probes to search for aav-3 fa-stainable antigens synthesized by these cells. the 333-8-9 cells inocu ... | 1975 | 163319 |
| quantitative assay for transformation of 3t3 cells by herpes simplex virus type 2. | the interaction of herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) with swiss/3t3 cells was investigated. virus-induced cytopathic effects developed in the absence of production of infectious virus. hsv-2 inactivated with uv light (2, 4, 6, and 8 min) also induced cell death in the absence of virus replication. cell death was not detectable after infection by hsv-2 that had been inactivated by uv irradiation for 10, 12, and 14 min. 3t3 cells infected with uv-inactivated virus (10 and 12 m ... | 1975 | 163369 |
| induction of human cell dna synthesis by herpes simplex virus type 2. | the effect of herpes simplex virus type 2 (hsv-2) infection on the synthesis of dna in human embryonic fibroblast cells was determined at temperatures permissive (37 c) and nonpermissive (42 c) for virus multiplication. during incubation of hsv-2 infected cultures at 42 c for 2 to 4 days or after shift-down from 42 to 37 c, incorporation of (3h)tdr into total dna was increased 2-to 30-fold as compared with mock-infected cultures. analysis of the (3h)dna suggested that host cell dna synthesis was ... | 1975 | 163370 |
| variation in susceptibility of different cell types to temperature-sensitive host range mutants of herpes simplex virus type 2. | 1975 | 163537 | |
| stimulation of human lymphocytes by herpes simplex virus antigens. | lymphocytes from individuals with laboratory evidence of prior infection with herpes simplex virus (hsv) type 1 or type 2 demonstrated transformation (av antigens. higher stimulation indexes were obtained when lymphocytes were incubated with the homologous as compared with the heterologous antigen. higher mean lymphocyte stimulation indexes were also demonstrated in seropositive as compared with seronegative individuals. lymphocytes from children with hsv-1 stomatitis usually became responsive t ... | 1975 | 163788 |
| spleen cell-mediated cytotoxicity of hamster cells transformed by herpes simplex virus: evidence for virus-specific membrane antigen. | the nature of the host's immune response to isografts of hamster embryo fibroblasts (hef) transformed by herpes simplex virus type 1 (hsv-1) was investigated by the microcytotoxicity assay. it was found that spleen cells from tumor-bearing hamsters killed homologous tumor cells but not hef transformed by cytomegalovirus or para-(defective sv40)-adenovirus 7 (para-7). cytotoxicity was lost as the tumor increased in size. spleen cells from animals bearing isografts of hsv type 2 (hsv-2) transforme ... | 1975 | 163859 |
| herpes simplex virus microneutralization: a simplification of the test. | the herpes simplex virus (hsv) microneutralization test has been simplified; its use has been demonstrated for the identification of hsv isolates as type 1 (hsv-1) or type 2 (hsv-2) and for the measurement of antibodies to hsv-1 and hsv-2. in this test, the relation between the neutralization titer and virus input is linear, and thus test results can be expressed as corrected neutralization titers, rather than as the more complex neutralizing potency values previously proposed. by means of this ... | 1975 | 163870 |
| differential action of deoxynucleosides on mammalian cell cultures infected with herpes simplex virus types 1 and 2. | cytopathic effects induced by eight serologically defined isolates of herpes simplex virus type 2 (tested on human amnion cells) were markedly inhibited by thymidine at a concentration of 5 mm; eight serologically defined isolates of herpes simplex virus type 1, however, were not significantly inhibited. a similar effect was seen with thymidine, deoxyguanosine, and deoxycytidine at 1-mm concentrations in tests with rabbit kidney cultures. the inhibitory effect of thymidine was not blocked by the ... | 1975 | 163871 |
| temperature-sensitive host range mutants of herpes simplex virus type 2. | herpesviruses are capable of several types of infection of a host cell. to investigate the early events which ultimately determine the nature of the virus-host cell interaction, a system was established utilizing temperature-sensitive mutants of herpes simplex virus type 2. four mutants have been isolated which fail to induce cytopathic effects and do not replicate at 39 c in hamster embryo fibroblast cells. at least one mutant is virus dna negative. since intracellular complementation is detect ... | 1975 | 163920 |
| demonstration of oncogenic potential of mammalian cells transformed by dna-containing viruses following photodynamic inactivation. | the oncogenic properties of hamster embryo cells transformed by herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) and sv40 virus following photodynamic inactivation using neutral red were determined by subcutaneous inoculation into newborn syrian hamsters. cells transformed by all three viruses produced palpable tumors after different latent periods. histopathological examination showed that hsv-2 tumors were fibrosarcomas and metastases were often seen in the lungs. hsv-2 primary tumors we ... | 1975 | 165153 |
| antibody to herpes simplex virus type 2-induced nonstructural proteins in women with cervical cancer and in control groups. | sera obtained from 15 patients with cervical cancer, 10 patients with breast cancer, and 15 control women, individually matched with the cervical cancer patients, were examined for antibodies to early proteins synthesized in herpes simplex virus type 2 (hsv-2)-infected cells. the method used was an indirect radioimmune precipitation test followed by polyacrylamide gel electrophoretic analysis of immune precipitates. the relative reactivity to a major early nonstructural protein (vp134) was used ... | 1975 | 165303 |
| tumor antigens in hamsters with sarcomas associated with herpesvirus type 2. | tumor-associated antigens (tta) were demonstrated in preparations of hamster sarcomas associated with herpes simplex virus type 2, as well as in the sera of tumor-bearing hamsters. an immunoadsorption-in-gel method was employed to demonstrate and purify the taa and anti-taa. these results suggest the potential use of this technique for the demonstration of taa or of anti-taa in humans or animals with cancer. | 1975 | 165539 |
| in vitro transformation of hamster cells by herpes simplex virus type 2 from human prostatic cancer cells. | a cell-associated herpes simplex virus type 2 found in a human prostatic carcinoma induced in vitro transformation of hamster embryo cells. the transformed cells (yw-74) have been shown to be hamster cells by karyotype analysis. their epithelial morphology and growth pattern, which are different from the parental cell, have remained stable through cell passages. the presence of herpesvirus antigens in the transformed cells was determined by specific immunofluorescence and colony inhibition tests ... | 1975 | 165889 |
| latent infection of sensory ganglia with herpes simplex virus: efficacy of immunization. | mice were used to test the efficacy of active immunization in preventing latent infection of local sensory ganglia that follows inoculation of superficial epithelial surfaces with herpes simplex virus. substantial but not complete protection was observed in animals immunized and challenged with herpes simplex virus type 1, but no protection was noted in animals immunized and challenged with herpes simplex virus type 2. latent ganglionic infection can develop in immunized animals despite the pres ... | 1975 | 166432 |
| polypeptide synthesized in herpes simplex virus type 2-infected hep-2 cells. | 1975 | 166500 | |
| oncogenic transformation of primary hamster cells by herpes simplex virus type 2 (hsv-2) and an hsv-2 temperature-sensitive mutant. | six oncogenically transformed cell lines were obtained following infection of hamster embryo fibroblasts with uv-irradiated herpes simplex virus type 2 (hsv-2) or with an hsv-2 temperature-sensitive mutant. all lines produced undifferentiated fibrosarcomas in newborn hamsters, four of the six lines produced metastatic tumors in the lung, and sera from tumor-bearing hamsters contained neutralizing antibody to hsv-2. hsv-specific cell-surface antigen (s) was detected by immunogluorescence tests in ... | 1975 | 166948 |
| antibody patterns to herpesviruses in kaposi's sarcoma: serological association of european kaposi's sarcoma with cytomegalovirus. | sera from patients with kaposi's sarcoma (ks) were examined for antibody titres to cytomegalovirus (cmv), epstein-barr virus (ebv) and herpes simplex virus (hsv) types 1 and 2 by four techniques: indirect haemagglutination (iha), complement fixation (cf), virus neutralization (nt) and indirect immunofluorescence (if). the patients were classified, according to the stage of disease, as progressive and regressive. control sera were obtained from healthy adults, matched for age, sex, race, socioeco ... | 1975 | 166949 |
| cervical carcinogenesis with herpes simplex virus, type 2. | in the past few years there have been a number of reports correlating a high frequency of herpes simplex virus type 2(hsv-2) infection with lesions of the uterine cervix. these studies have used a clinical history of herpetic infection or the demonstration of herpetic antibodies in the cancer patients. the present study was performed to evaluate any possible carcinogenic activity of the formalin-inoculated herpes simplex virus type 2 in the reproductive tract of the female mouse. this approach t ... | 1975 | 168521 |
| viral gene functions expressed and detected by temperature-sensitive mutants of herpes simplex virus. | the expression of hsv-specific gene functions by 22 ts mutants of hsv-1 in 15 complementation groups and 8 ts mutants of hsv-2 in 7 complementation groups has been studied at the nonpermissive temperature. four cistrons of hsv-1 and three cistrons of hsv-2 with defects in viral dna and dan polymerase synthesis were identified. dna-mutants of hsv-1 revealed a greater alteration in hsv polypeptide synthesis and viral assembly than dna- mutants of hsv-2. mutants with apparent defects in structural ... | 1975 | 169028 |
| letter: herpes simplex virus 2, (hsv2) as the carcinogen in cancer of the cerivx. | 1975 | 169222 | |
| experimental infection with herpes simplex virus type 2 in newborn rats: effects of treatment with iododeoxyuridine and cytosine arabinoside. | sprague-dawley rats were inoculated, within 36 hr of birth, with either of two strains of herpes simplex virus type 2. the effects of treatment for five days with either 5-iododeoxyuridine or cytosine arabinoside in near toxic doses were studied. evaluation of treatment based on rate of survival, incidence of lesions, and isolation of virus from the central nervous system showed no appreciable difference between treated and untreated littermates. drug-related effects of retardation of growth and ... | 1975 | 169311 |
| antibodies to herpes simplex virus in jewish women with cervical cancer and in healthy jewish women of israel. | herpes simplex virus (hsv) antibody titers were examined in sera from 39 jewish women with squamous cell carcinoma of the uterine cervix (cacx) and in sera from controls matched by age and country of origin. highly significant differences were found between the cases and controls for both hsv type 1 (hsv-1) and hsv type 2 (hsv-2). compared to findings in other demographic areas, the geometric mean titer (gmt) of hsv-1 among the cacx cases were considerably higher, whereas the gmt for hsv-2 was i ... | 1975 | 169365 |
| [the present status of the theory of induction of carcinoma of the cervix in man by herpes virus (author's transl)]. | a large body of evidence has accumulated during the past decade suggesting that hsv-2 infection of the cervix may be a major precursor of cervical carcinoma. a brief review of the more significant findings to date is presented. | 1975 | 170159 |
| transformation of mouse cells after infection with ultraviolet irradiation-inactivated herpes simplex virus type 2. | a transformed mouse cell line (h238) was obtained following the infection of 238 mouse cells with ultraviolet (uv) irradiation-inactivated herpes simplex virus type 2 (hsv-2). the transformed cells produced tumors with a 100% incidence within 8 weeks in 6-week-old syngeneic balb/c mice at an inoculum of 1 times 10(6). indirect immunofluorescence (if) tests revealed the presence of hsv antigens in the transformed cells. antibodies to hsv-2 were found in the sera of tumor-bearing animals by neutra ... | 1975 | 170223 |
| optimal cooling and warming rates in the preservation of herpes simplex virus (type 2). | fast rates of cooling and warming were optimal for survival of herpes simplex virus, type 2. under these conditions cryoprotectants were not necessary for virus preservation. | 1975 | 170319 |
| the epidemiology and interrelationship of cervical dysplasia and type 2 herpesvirus in a low-income housing project. | this report examines the association between cervical dysplasia and herpes simplex virus type 2 antibodies in a low-income housing project, atlanta, georgia. we established a clinic in this project at which women could receive a breast examination and papanicolaou smear and have blood drawn to be tested for herpesvirus type 2 antibodies. prevalence of herpesvirus rose sharply as age increased. there was a significant absence of antibodies in young, nulliparous women. dysplasia showed a tendency ... | 1975 | 170825 |
| in vivo characteristics of temperature-sensitive host range mutants of herpes simplex virus type 2. | the in vivo properties of four host range temperature-sensitive (ts) mutants of herpes simplex virus type 2 (hsv-2) were correlated with known in vitro characteristics. mutants and parental virus were inoculated into newborn and weanling mice and weanling hamsters by intracranial and subcutaneous routes, and into weanling rabbits by corneal scarification. in all cases the pattern of attenuation of mutants in vivo correlated with their stability in vitro at 39 degrees. the most attenuated mutant ... | 1975 | 171235 |
| effect of adeno-associated virus on cancer expression by herpesvirus-transformed hamster cells. | infection of herpes simplex virus type-2-transformed hamster tumor cells with adeno-associated virus type 1 before inoculation into hamsters specifically delayed the appearance of palpable tumors and increased the survival time of the animals. the data indicated that a defective virus of humans can influence cancer expression by a virus-transformed cell. | 1975 | 171433 |
| comparison of the virion proteins specified by herpes simplex virus types 1 and 2. | purified herpes simplex virus type 2 (hsv-2) virions were found to contain approximately the same number of polypeptides as hsv type 1 (hsv-1) virions. comparisons of the structural proteins specified by five independent hsv-2 isolates revealed some minor differences in their electrophoretic profiles on sodium dodecyl sulfate-acrylamide gels; certain invariant features of the electrophoretic profiles, however, allowed clear differentiation between all the hsv-2 isolates and hsv-1. | 1975 | 171455 |
| induction of cellular dna synthesis by a temperature-sensitive mutant of herpes simplex virus type 2. | 1975 | 171835 | |
| the fate of herpes simplex virus type 2 dna during abortive infection at 42 degrees c of hyman embryonic lung cells. | 1975 | 171852 | |
| solid phase radioimmunoassay for typing herpes simplex viral antibodies in human sera. | an indirect solid phase radioimmunoassay (ria) was developed for typing antibody to herpes simplex virus (hsv) types 1 and 2 (hsv-1 and hsv-2) in human sera. the test is based upon absorption of sera with uninfected, hsv-1-infected cells and testing for residual antibody. the high sensitivity of the ria method for detecting hsv antibody permits examination of sera at high dilutions, and thus relatively small volumes of virus-infected cells are required for cross-absorption of antibodies. results ... | 1975 | 172526 |
| dna polymerase induction by dna-negative temperature-sensitive mutants of herpes simplex virus type 2. | 1975 | 173076 | |
| genital herpes simplex virus type 1 infection--variability in modes of spread. | ever since the first report in 1967 of the association of herpes simplex virus type 2 (hsv-2) with urogenital infections, we have noted the occasional isolation of hsv-1 from such sites. our most recent results of the typing of hsv isolates from 527 individuals with urogenital infections show that 10.9% of such infections in females and 3.4% in males are caused by hsv-1. we describe here the acquisition of a primary oral hsv-1 infection in a male after orogenital contact with his wife who had a ... | 1975 | 173699 |
| differential feulgen-deoxyribonucleic acid hydrolysis patterns of herpes simplex virus type 1 and type 2 infected cells. | infection of human embryonic lung cells with herpes simplex virus type 1 (hsv-1) and herpes simplex type 1 (hsv-2) resulted in: (a) qualitative (nuclear cytopathologic) alterations and quantitative (nuclear area) differences in infected compared to control nuclei; (b) increased feulgen-deoxyribonucleic acid (f-dna) amounts in infected cells, probably due to viral dna; (c) higher f-dna levels in hsv-2 infected cells; and (d) increased rates of f-dna hydrolysis in viral-infected as compared to uni ... | 1975 | 47871 |
| glycoproteins specified by herpes simplex virus type 1: their synthesis, processing and antigenic relatedness to hsv -2 glycoproteins. | 1975 | 65316 | |
| a study of the immuno-suppressive activity of herpes simplex virus type 2 and the tumor enhancing potential of the virus on yoshida sarcoma. | the relative delays of yoshida sarcoma (ys) tumor induction were used as indicator for the immunosuppressive potential caused by the subcutaneous infection of sprague-dawley rats with approximately 10(7) tcd50 hsv-2. the tumor formation is clearly accelerated and the number of tumors is increased as compared to sham injected rats. the impairment of immunity is at its maximum when the virus and the ys cells are applied simultaneously, whereas virus given after the tumor is of no consequence. the ... | 1975 | 174048 |
| herpes simplex virus type 2 and acute aseptic meningitis. clinical features of cases with isolation of herpes simplex virus from cerebrospinal fluids. | herpes simplex virus (hsv) was recovered from the cerebrospinal fluids (csf) of 10 patients with acute aseptic meningitis. hsv type 1 was isolated from the csf of a 6-month-old boy. the other 9 hsv isolates from csf were from adults in the age-group 15 to 29 years; 7 of these isolates were available for typing and were identified as hsv type 2. in a further 9 patients with acute aseptic meningitis and belonging to the same age-group a hsv infection was suggested by a significant titre rise in co ... | 1975 | 174191 |
| prospective double-blind evaluation of topical adenine arabinoside in male herpes progenitalis. | thirty-four virologically proven episodes of herpes progenitalis in 32 men were treated in a prospective double-blind study with either adenine arabinoside ointment or an identical-appearing placebo for 7 days. clinical evaluation and quantitative virological studies were done on days 1, 3, and 8. there was a highly significant correlation between clinical response and quantitative virology. there was no difference in clinical or virological response between drug and control groups. primary atta ... | 1975 | 174489 |
| [seroepidemiological studies related to the association of genital herpes to cervical cancer (author's transl)]. | blood sera of 290 patients were examined for the presence of antibodies against herpes simplex virus type 1 and type 2 (hsv-1 and hsv-2): 1. lues - seronegative individuals, 2. patients with specific lues antibodies, and 3. patients with so-called carcinoma in situ and invasive carcinoma of the uterine cervix. the group of syphilis-seropositive individuals served as control for the group with cervical lesions, because in both groups certain socioepidemiologic factors (promiscuity, early sexual i ... | 1975 | 174969 |
| [recurrent neonatal herpetic infection: isolation of herpes simplex virus type 2]. | 1975 | 179230 | |
| comparison of herpes simplex virus isolates using a quantitative selection assay for transformation. | transformation potential of herpes simplex virus types 1 and 2 (hsv-1 and hsv-2) was quantitatively compared in a system selecting for biochemical transformants. the highest frequency of transformation was obtained with hsv-2 strain 333. the transformation rates for two strains of hsv-1 were lower and distinctly different from hsv-2 and from each other. the dose of inactivating ultraviolet light received by the virus and the multiplicity of infection proved to be critical components of the proce ... | 1975 | 179966 |
| characterization of single-cell clonal lines derived from hsv-2-transformed mouse cells. | a balb/c continuous cell line, 238, was transformed following infection with uv-inactivated herpes simplex virus type 2 (hsv-2) was designated h238. several cell lines were derived from single cells of h238 by cloning in soft agar. the clonal lines express cytoplasmic antigens by immunofluorescence when reacted with rabbit hsv-2 antiserum and mouse tumor-bearer serum. the cloned cell lines induce tumors in immunocompetent mice by the subcutaneous route with a 100% incidence at an inoculum of 10( ... | 1975 | 184064 |
| plaque dissociation of herpes simplex viruses: biochemical and biological characters of the viral variants. | polycaryocytogenic (p) and non-polycaryocytogenic, or aggregating (a), stable variants were selected from a herpes simplex virus type 1 (hsv-1) and from a herpes simplex virus type 2 (hsv 2) which had not been deliberately exposed to known mutagenic agents. the p variant of hsv-1 (fp) differed from the a variant (fa) in polypeptides and glycoprotein patterns, but no gross differences were evident between the two variants of hsv-2 (gp and ga). each p variant proved more 'specific' than each a var ... | 1975 | 186433 |
| comparison of dna polymerase activities induced by herpes simplex virus types 1 and 2. | hsv-2-induced a salt-stimulated dna polymerase activity in hep-2 cells at similar levels to that induced by hsv-1 virus at multiplicites of infection from 2 to 20 pfu/cell. de novo synthesis of protein and mrna was required for dna polymerase induction by both types. dna polymerase activity of three strains of each type was compared by response to various salt concentrations and by heat inactivation. strain-dependent, but not type-dependent differences were found by both tests. considerable cros ... | 1975 | 187552 |