Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| [effect of panavir on herpes simplex virus types 1 and 2 proteins synthesis in cell culture]. | the effect of panavir on the synthesis of ultraearly (alpha), early (beta) and late (gamma) proteins of herpes simplex virus types 1 and 2 in the culture of vero cells was studied. it was shown that the level of the proteins suppression depended on the infection multiplicity and the time of the panavir addition to the culture. | 2009 | 19711844 |
| aetiology of genital ulcer disease in female partners of male participants in a circumcision trial in uganda. | hiv acquisition is associated with herpes simplex virus type 2 (hsv-2) infection and genital ulcer disease (gud). three randomized control trials demonstrated that male circumcision significantly decreases hiv, hsv-2, human papillomavirus and self-reported gud among men. gud is also decreased among female partners of circumcised men, but it is unknown whether male circumcision status affects gud pathogens in female partners. for the evaluation of gud aetiology, two separate multiplex assays were ... | 2009 | 19710342 |
| herpes simplex virus type 2 and hiv infection among us military personnel: implications for health prevention programmes. | us military personnel are routinely screened for hiv infection. herpes simplex virus type 2 (hsv-2) is a risk factor for hiv acquisition. to determine the association between hsv-2 and hiv, a matched case-control study was conducted among us army and air force service members with incident hiv infections (cases) randomly matched with two hiv-uninfected service members (controls) between 2000 and 2004. hsv-2 prevalence was significantly higher among cases (30.3%, 138/456) than among controls (9.7 ... | 2009 | 19710337 |
| detection of herpes simplex virus dna in plasma of patients with primary but not with recurrent infection: implications for transfusion medicine? | among the family of herpes viruses, only cytomegalovirus (cmv) and, to a lesser extent, human herpes virus 8 (hhv-8) are of relevance in transfusion medicine. due to neutropism, herpes simplex viruses (hsv) types 1 and 2 are considered to be of minor relevance. however, several reports gave evidence that a hsv dnaemia might occur and hsv could therefore be transmissible by blood products. the aim of our study was to collect data about prevalence of hsv antibodies among blood donors and to clarif ... | 2010 | 19708895 |
| association of age at first sex with hiv-1, hsv-2, and other sexual transmitted infections among women in northern tanzania. | to examine the association between age at first sex and the prevalence of sexually transmitted infections (stis), including hiv-1 and hsv-2, in women in moshi urban district, northern tanzania. | 2009 | 19707109 |
| antiviral activity of ethanol extracts of ficus binjamina and lilium candidum in vitro. | the antiviral activity of plant ethanol extracts against herpes simplex virus-1 and -2 (hsv-1 and hsv-2) and varicella-zoster virus (vzv) was investigated in vitro. ficus binjamina, resistant to plant viruses, and lilium candidum, which has a high susceptibility to plant viruses were used. leaf extracts of f. binjamina inhibited all studied viruses, while its fruit extracts inhibited only vzv. l. candidum leaf extracts had no effect on vzv but strongly inhibited hsv-1 and slightly hsv-2. none of ... | 2009 | 19703599 |
| protection from herpes simplex virus (hsv)-2 infection with replication-defective hsv-2 or glycoprotein d2 vaccines in hsv-1-seropositive and hsv-1-seronegative guinea pigs. | a herpes simplex virus (hsv)-2 candidate vaccine consisting of glycoprotein d (gd2) in alum and monophosphoryl lipid a (mpl) reduced genital herpes disease in hsv-1-seronegative women but not in men or hsv-1-seropositive women. | 2009 | 19702506 |
| a missed point in deciphering the viral synergy between herpes simplex virus and hiv. | 2009 | 19695487 | |
| rapid diagnosis of herpetic encephalitis in children by pcr-microarray technology for simultaneous detection of seven human herpes viruses. | the aim of the study was to evaluate retrospectively the usefulness of polymerase chain reaction (pcr)-microarray technology, which can simultaneously detect seven human herpes viruses for rapid and accurate diagnosis of herpetic encephalitis in children. we simultaneously amplified herpes simplex virus type 1 and type 2 (hsv-1 and hsv-2); varicella-zoster virus; epstein-barr virus (ebv); cytomegalovirus (cmv); and human herpes virus 6 (hhv-6a and hhv-6b) by multiplex pcr, and genotyped by dna m ... | 2010 | 19685343 |
| from causality to prevention - the example of cervical cancer: my personal contribution to this fascinating history. | the history of the generation of an hypothesis linking human papillomavirus to cervical cancer, as well as a summary of the various molecular epidemiological studies undertaken to confirm such hypothesis are described. | 2009 | 19684449 |
| mechanism of herpes simplex virus type 2 suppression by propolis extracts. | genital herpes caused by herpes simplex virus type 2 (hsv-2) is a chronic, persistent infection spreading efficiently and silently as sexually transmitted disease through the population. antiviral agents currently applied for the treatment of herpesvirus infections include acyclovir and derivatives. aqueous and ethanolic extracts of propolis were phytochemically analysed, different polyphenols, flavonoids and phenylcarboxylic acids were identified as major constituents. the aqueous propolis extr ... | 2010 | 19682876 |
| perceptions of couple hiv counseling and testing in botswana: a stakeholder analysis. | to explore stakeholder's perceptions of couples hiv counseling and testing (chct) as opposed to individual testing and potential couples' preferences for chct promotion and service provision. | 2010 | 19682831 |
| chromatin assembly on herpes simplex virus genomes during lytic infection. | the human herpes simplex viruses hsv-1 and hsv-2 infect a significant portion of the human population. both viruses can undergo lytic infection in epithelial cells and establish lifelong latency in neuronal cells. the large hsv-1 dna genomes have long been considered to be devoid of histones both inside the virion particle and inside the cell during lytic infection, but to be packaged in repressive chromatin during latency. however, recent reports indicate that many histone and non-histone chrom ... | 2010 | 19682614 |
| herpes simplex encephalitis during treatment with tumor necrosis factor-alpha inhibitors. | we report 3 cases of herpes simplex virus encephalitis in patients receiving tumor necrosis factor-alpha (tnf-alpha) inhibitors for rheumatologic disorders. although tnf-alpha inhibitors have been reported to increase the risk of other infectious diseases, to our knowledge, an association between anti-tnf-alpha drugs and herpes simplex virus encephalitis has not been previously described. | 2009 | 19681709 |
| once daily valacyclovir for reducing viral shedding in subjects newly diagnosed with genital herpes. | genital herpes (gh) recurrences and viral shedding are more frequent in the first year after initial hsv-2 infection. the objective of this study was to provide the first evaluation of valacyclovir 1 g once daily compared to placebo in reducing viral shedding in subjects newly diagnosed with gh. | 2009 | 19680456 |
| serological profile of hsv-2 in patients attending sti clinic: evaluation of diagnostic utility of hsv-2 igm detection. | the present study was done to evaluate the serological profile of herpes simplex virus-2 (hsv-2) among patients attending sexually transmitted infections (sti) clinic and to determine the utility of detecting hsv-2 igm antibodies in such patients. a correlation of hsv-2 infection with other sti including hiv has also been attempted. | 2009 | 19679959 |
| measurement and predictors of adherence in a trial of hsv suppressive therapy in tanzania. | this study estimates adherence and identifies predictors of good adherence among 1305 tanzanian women participating in a randomised, double-blind, placebo-controlled trial of hsv suppressive therapy to reduce hiv incidence or genital hiv shedding. women were randomised to acyclovir 400mg bd or placebo and followed every three months for 12-30 months. adherence was assessed by tablet counts. random urine samples, collected between 6 and 24 months, were tested for acyclovir. at 12, 24 and 30 month ... | 2009 | 19665587 |
| estradiol improves genital herpes vaccine efficacy in mice. | herpes simplex virus type 2 causes genital herpes but is frequently transmitted asymptomatically; therefore, a prophylactic vaccine is desirable. a candidate vaccine in clinical trials has only shown efficacy in preventing disease in women. using this subunit vaccine candidate, we were able to demonstrate infection prophylaxis, improved disease prevention and modulated antibody production by complimenting vaccination with estradiol in our murine model. findings of estradiol-enhanced vaccine effi ... | 2009 | 19660586 |
| mucosal innate and adaptive immune responses against herpes simplex virus type 2 in a humanized mouse model. | genital herpes, caused by herpes simplex virus type 2 (hsv-2), is one of the most prevalent sexually transmitted diseases worldwide and a risk factor for acquiring human immunodeficiency virus. although many vaccine candidates have shown promising results in animal models, they have failed to be effective in human trials. in this study, a humanized mouse strain was evaluated as a potential preclinical model for studying human immune responses to hsv-2 infection and vaccination. immunodeficient m ... | 2009 | 19656896 |
| hepatitis b infection is highly endemic in uganda: findings from a national serosurvey. | infant immunization against hepatitis b began in uganda in 2002. | 2009 | 19652743 |
| persistence of hiv-1 receptor-positive cells after hsv-2 reactivation is a potential mechanism for increased hiv-1 acquisition. | to explore the mechanism by which herpes simplex virus (hsv)-2 infection is related to hiv-1 acquisition, we conducted in situ analysis of the cellular infiltrate from sequential biopsies of hsv-2 lesions from patients on and off antiviral therapy. cd4(+) and cd8(+) t cells and a mixed population of plasmacytoid and myeloid dendritic cells (dcs), including cells expressing the c-type lectin receptor dc-sign, persisted at sites of hsv-2 reactivation for months after healing, even with daily antiv ... | 2009 | 19648930 |
| latency-associated transcript (lat) exon 1 controls herpes simplex virus species-specific phenotypes: reactivation in the guinea pig genital model and neuron subtype-specific latent expression of lat. | herpes simplex virus 1 (hsv-1) and hsv-2 cause similar acute infections but differ in their abilities to reactivate from trigeminal and lumbosacral dorsal root ganglia. during latency, hsv-1 and hsv-2 also preferentially express their latency-associated transcripts (lats) in different sensory neuronal subtypes that are positive for a5 and kh10 markers, respectively. chimeric virus studies showed that lat region sequences influence both of these viral species-specific phenotypes. to further map t ... | 2009 | 19641003 |
| herpes simplex virus 2 ul13 protein kinase disrupts nuclear lamins. | herpesviruses must cross the inner nuclear membrane and underlying lamina to exit the nucleus. hsv-1 us3 and pkc can phosphorylate lamins and induce their dispersion but do not elicit all of the phosphorylated lamin species produced during infection. ul13 is a serine threonine protein kinase conserved among many herpesviruses. hsv-1 ul13 phosphorylates us3 and thereby controls ul31 and ul34 nuclear rim localization, indicating a role in nuclear egress. here, we report that hsv-2 ul13 alone induc ... | 2009 | 19640559 |
| high risk behaviors and sexually transmitted infections among men in tanzania. | we assessed the association between risk behaviors and sexually transmitted infections (stis) among men. we interviewed 794 men randomly selected from moshi district of tanzania. blood and urine samples were tested for stis. about 46% of the men tested positive for at least one sti including human immunodeficiency virus (hiv-1), herpes simplex virus (hsv-2), syphilis, chlamydia, trichomonas, and mycoplasma infection. multiple sexual partners, casual sex, alcohol abuse, and older age were associa ... | 2009 | 19636698 |
| new concepts in herpes simplex virus vaccine development: notes from the battlefield. | the recent discovery that t cells recognize different sets of herpes simplex virus type 1 and type 2 epitopes from seropositive symptomatic and asymptomatic individuals might lead to a fundamental immunologic advance in vaccine development against herpes infection and diseases. the newly introduced needle-free mucosal (i.e., topical ocular and intravaginal) lipopeptide vaccines provide a novel strategy that might target ocular and genital herpes and possibly provide 'heterologous protection' fro ... | 2009 | 19627185 |
| prevalence and risk factors of human papillomavirus infection by penile site in uncircumcised kenyan men. | human papillomavirus (hpv) prevalence was estimated from 2,705 sexually active, uncircumcised, human immunodeficiency virus seronegative men aged 17-28 years in kisumu, kenya. hpv prevalence was 51.1% (95% confidence interval: 49.2-53.0%) in penile cells from the glans/coronal sulcus and/or shaft. hpv prevalence varied by anatomical site, with 46.5% positivity in the glans/coronal sulcus compared with 19.1% in the shaft (p < 0.0001). high-risk hpv was detected in 31.2% of glans and 12.3% of shaf ... | 2010 | 19626601 |
| recurrent lumbosacral herpes simplex in two men. | two cases of recurrent lumbosacral herpes simplex without concomitant genital lesions are reported. both patients presented with vesicular lesions on the middle of the lower back and on the left thigh, respectively, and had positive serum antibody to herpes simplex virus type 2 and negative antibody to hiv. the lesions healed completely within 1 week by oral administration of acyclovir. | 2009 | 19625294 |
| recurrent lymphocytic meningitis positive for herpes simplex virus type 2. | we found the prevalence of recurrent lymphocytic meningitis associated with herpes simplex virus type 2 (hsv-2) was 2.2/100,000 population in finland during 1996-2006, higher than previous estimates. pcr was most sensitive in detecting hsv-2 dna from cerebrospinal fluid if the sample was taken 2-5 days after symptom onset. | 2009 | 19624935 |
| herpes simplex virus type-2 seropositivity among ever married women in south and north vietnam: a population-based study. | to investigate herpes simplex virus type-2 (hsv-2) seropositivity and associated risk factors in vietnamese women. | 2009 | 19617867 |
| male circumcision for the prevention of hsv-2 and hpv infections. | 2009 | 19610160 | |
| male circumcision for the prevention of hsv-2 and hpv infections. | 2009 | 19605839 | |
| a pooled analysis of the effect of condoms in preventing hsv-2 acquisition. | the degree of effectiveness of condom use in preventing the transmission of herpes simplex virus 2 (hsv-2) is uncertain. to address this issue, we performed a large pooled analysis. | 2009 | 19597073 |
| cxcr3 deficiency increases susceptibility to genital herpes simplex virus type 2 infection: uncoupling of cd8+ t-cell effector function but not migration. | cxcr3 is a g-protein-coupled receptor preferentially expressed by activated t cells, nk cells, and dendritic cells. signaling through gamma interferon-regulated chemokines cxcl9, cxcl10, cxcl11, and cxcr3 plays a critical role in the immune response of many viral pathogens. however, the relevance of cxcr3 for optimal t-cell activation and the induction of regulatory transcription factors (i.e., t-bet and eomesodermin) relative to host immune defense against genital herpes simplex virus type 2 (h ... | 2009 | 19587047 |
| increased eif2alpha phosphorylation attenuates replication of herpes simplex virus 2 vhs mutants in mouse embryonic fibroblasts and correlates with reduced accumulation of the pkr antagonist icp34.5. | herpes simplex virus 2 (hsv-2) strains containing mutations in the virion host shutoff (vhs) protein are attenuated for replication compared with wild-type virus in mouse embryonic fibroblasts (mefs). however, hsv-2 vhs mutants replicate to near wild-type levels in the absence of the rna-activated protein kinase (pkr). pkr is one of several kinases that phosphorylates the eukaryotic initiation factor 2alpha (eif2alpha) to inhibit translation initiation, and we previously found that more of the p ... | 2009 | 19587046 |
| fulminant and accelerated presentation of dermatomyositis in two previously healthy young adult males: a potential role for endotheliotropic viral infection. | dermatomyositis (dm) is a prototypic autoimmune syndrome, whereby immune-based microvascular injury is critical in the pathogenesis of skin lesions and the myopathy. although not widely recognized or accepted as a pathogenetic trigger, endotheliotropic viral triggers including parvovirus b19 and cytomegalovirus have been linked to dm. at times, the clinical manifestations in dm can be fulminant with acute renal failure because of rhabdomyolysis, respiratory failure and gastrointestinal infarcts. | 2009 | 19586495 |
| foreskin inflammation is associated with hiv and herpes simplex virus type-2 infections in rakai, uganda. | we assessed foreskin inflammation associated with hiv and herpes simplex virus type 2 (hsv-2) in circumcised men. | 2009 | 19584700 |
| detection of opportunistic dna viral infections by multiplex pcr among hiv infected individuals receiving care at a tertiary care hospital in south india. | opportunistic viral infections cause increased morbidity and mortality among human immunodeficiency virus (hiv) infected individuals, especially those who are not on antiretroviral treatment. early diagnosis of these opportunistic viruses will be able to reduce the risk of disease progression with appropriate intervention. | 2009 | 19584500 |
| simultaneous detection of viruses and toxoplasma gondii in cerebrospinal fluid specimens by multiplex polymerase chain reaction-based reverse hybridization assay. | the lack of rapidity and the low sensitivity and specificity of traditional laboratory methods limits their usefulness in the laboratory diagnosis of viral central nervous system (cns) infections. this study describes the use of a commercially available multiplex polymerase chain reaction (mpcr)-based reverse hybridization assay (rha) for the simultaneous detection of the genomes of 8 viruses and toxoplasma gondii in cerebrospinal fluids (csf) from 181 patients suspected of having viral meningit ... | 2009 | 19579690 |
| virucidal activity of polysaccharide extracts from four algal species against herpes simplex virus. | herpes simplex virus types 1 and 2 (hsv-1, hsv-2) infections are common, but can cause serious infections in neonates and the immunocompromised. drugs currently used to treat cutaneous or genital hsv infections are effective in limiting disease, but the emergence of drug resistant viruses in immunocompromised individuals can be problematic. while the prophylactic oral treatment with antiviral drugs can reduce virus shedding and transmission, there is a need for topical microbicides that have the ... | 2009 | 19576248 |
| influenza-like illness sentinel surveillance in peru. | acute respiratory illnesses and influenza-like illnesses (ili) are a significant source of morbidity and mortality worldwide. despite the public health importance, little is known about the etiology of these acute respiratory illnesses in many regions of south america. in 2006, the peruvian ministry of health (moh) and the us naval medical research center detachment (nmrcd) initiated a collaboration to characterize the viral agents associated with ili and to describe the clinical and epidemiolog ... | 2009 | 19568433 |
| epidemiology of sexually transmitted infections in suspected child victims of sexual assault. | the objective of this study was to describe the epidemiology of neisseria gonorrhoeae, chlamydia trachomatis, trichomonas vaginalis, treponema pallidum, hiv, and herpes simplex virus type 2 (hsv-2) infection diagnosed by culture or by serologic or microscopic tests and by nucleic acid amplification tests in children who are evaluated for sexual victimization. | 2009 | 19564286 |
| herpes simplex type-2 meningitis: presentation and lack of standardized therapy. | herpes simplex type-2 (hsv-2) causes both primary and recurrent lymphocytic meningitis, but optimal patient management is not well defined. | 2009 | 19559173 |
| upstairs and downstairs: socio-economic and gender interactions in herpes simplex virus type 2 seroprevalence in australia. | this study investigates socio-economic differentials in herpes simplex virus type 2 (hsv-2) seroprevalence in australian men and women using individual and geographic measures of socio-economic status. | 2009 | 19556928 |
| monitoring of herpes simplex virus dna types 1 and 2 viral load in cerebrospinal fluid by real-time pcr in patients with herpes simplex encephalitis. | a quantitative polymerase chain reaction (pcr) assay was evaluated retrospectively on 92 cerebrospinal fluid (csf) samples from 29 patients with herpes simplex virus (hsv) encephalitis with the aim to study if the concentration of hsv genomes can be used as a prognostic marker and for monitoring of antiviral therapy. the results were compared to those obtained previously by nested pcr, and the numbers of hsv genomes/ml were evaluated in correlation to patient outcome and treatment. the aims were ... | 2009 | 19551833 |
| high g+c content of herpes simplex virus dna: proposed role in protection against retrotransposon insertion. | the herpes simplex virus dsdna genome is distinguished by an unusually high g+c nucleotide content. hsv-1 and hsv-2, for instance, have gc contents of 68% and 70% respectively, while that of the host (human) genome is 41%. to determine how gc content varies with genome location, gc content was measured separately in coding and intergenic regions of hsv-1 dna. the results showed that the 75 genes constitute a uniform population with a mean gc content of 66.9 +/- 4.1%. in contrast, intergenic regi ... | 2007 | 19543363 |
| phenotype of atopic dermatitis subjects with a history of eczema herpeticum. | a subset of subjects with atopic dermatitis (ad) are susceptible to serious infections with herpes simplex virus, called eczema herpeticum, or vaccina virus, called eczema vaccinatum. | 2009 | 19541356 |
| type 2 herpes simplex reactivation after craniocervical decompression for hind brain hernia and associated syrinx. | herpes virus reactivation is a well-known phenomenon rarely described in neurosurgery. we report a case of type 2 herpes simplex virus reactivation following neurosurgery of the posterior fossa. cerebrospinal fluid analysis revealed a lymphocytic pleocytosis of over 200 x 10(6)/l. viral reactivation should be considered in patients with fever, meningism and extended hospital admission following neurosurgical procedures. | 2009 | 19533470 |
| hiv among injecting drug users: current epidemiology, biologic markers, respondent-driven sampling, and supervised-injection facilities. | to describe recent research done primarily during the past 12 months (i.e., primarily in 2008) on the epidemiology of hiv infection among injecting drug users (idus). | 2009 | 19532069 |
| herpes simplex virus type 2 and syphilis infections with hiv: an evolving synergy in transmission and prevention. | herpes simplex virus type 2 (hsv-2) and syphilis are associated with hiv infection. the purpose of this review is to summarize the advances in the relationship of hsv-2 and syphilis with hiv, highlighting intervention trials to prevent hiv acquisition and transmission. | 2009 | 19532067 |
| hiv in adolescents in sub-saharan africa. | in this review, we summarize existing evidence on the effectiveness of different intervention approaches to hiv prevention in adolescents - focusing on studies that are either from or are relevant to sub-saharan africa. in addition, we include a brief review of other salient issues relevant to hiv prevention research in adolescents. | 2009 | 19532066 |
| impact of acyclovir on genital and plasma hiv-1 rna, genital herpes simplex virus type 2 dna, and ulcer healing among hiv-1-infected african women with herpes ulcers: a randomized placebo-controlled trial. | little is known about the impact of episodic treatment of herpes on human immunodeficiency virus type 1 (hiv-1). | 2009 | 19530940 |
| [is the presence of herpesviruses in cervical secretions a prognostic factor for cervical pathology in hpv-positive women?]. | cervical carcinogenesis is a complex problem where papillomavirus is widely accepted as a causative agent. the correlation of cmv, ebv, hsv-1, hsv-2 with precancerous and cancer cervical lesions was investigated in 125 women with different diagnosis: lsil- 44, hsil- 12, cervical carcinoma-27 vs. 42 women without abnormality in cytology (control group). cervical secretion samples were submitted for dna extraction and determined by pcr and npcr. hpv dna genotyping was performed with the reverse hy ... | 2009 | 19522235 |
| clinical problem-solving. kiss of death. | 2009 | 19516037 | |
| the potential role of biomarkers in hiv preventive vaccine trials. | successful conduct of hiv vaccine efficacy trials entails identification and enrollment of at-risk populations, assessment of appropriate end points as measures of vaccine efficacy for prevention of hiv acquisition, and amelioration of disease course among infected vaccinees, as well as identification of potential confounders or effect modifiers. although not invariably useful and bringing their own cost in terms of measurement and validation, a variety of biomarkers may aid at each stage of tri ... | 2009 | 19512938 |
| herpes simplex virus type 2: a key role in hiv incidence. | 2009 | 19512858 | |
| herpes simplex virus infection downmodulates nkg2d ligand expression. | herpes simplex virus (hsv) type 1 infection may cause orofacial infections in humans. the virus resides in a latent form in neural ganglia and occasionally reactivates and infects epithelial cells. natural killer (nk) cells have been implicated in immune control of herpes virus infections, possibly by downmodulating major histocompatibility complex (mhc) class i and by other, as yet unidentified, mechanisms. upon hsv-1 infection of cell lines, surface levels of nkg2d ligands mhc class i related ... | 2009 | 19508374 |
| investigation of the mechanism by which herpes simplex virus type 1 lat sequences modulate preferential establishment of latent infection in mouse trigeminal ganglia. | we previously demonstrated that herpes simplex virus type 1 (hsv-1) preferentially establishes latent infection in monoclonal antibody (mab) a5-positive ganglionic neurons and that a 2.8-kb portion of the hsv-1 genome, corresponding to the 5' end of the lat (latency-associated transcript) coding region, is responsible for this phenotype (38, 65). in the current study we carried out further genetic mapping of this latency phenotype and investigated some of the mechanisms that might be responsible ... | 2009 | 19493993 |
| rapid isolation of hsv-1 and hsv-2 from oneswab cervicovaginal specimens. | herpes simplex viruses are significant human pathogens which remain latent in their hosts for life and reactivate to cause disease at or near the initial site of infection. since hsv infections are associated with high morbidity, rapid detection and diagnosis of these viruses is imperative. while pcr technology for the diagnosis of hsv is now almost utilized universally, virus isolation from mucosa and skin in shell cultures is still applied in many clinical settings. virus growth in cultured ce ... | 2009 | 19490968 |
| mannose-binding lectin 2 gene polymorphism in recurrent herpes simplex virus 2 infection. | mannose-binding lectin (mbl) is a complement component and an opsonic factor recognizing and binding to herpes simplex virus 2 (hsv-2). in this study, we assessed the effect of mbl2 genotypes on the risk of recurring hsv-2 infection. the mbl2 structural variant genotype (a/o or o/o) was more common among the patients with recurrent hsv-2 infection compared with healthy controls (47% vs 26%, respectively; odds ratio [or] = 2.6, 95% confidence interval [ci] 1.3-4.9; p = 0.005) or controls positive ... | 2009 | 19480845 |
| serological microarray for detection of hsv-1, hsv-2, vzv, and cmv antibodies. | the seroprevalence of human herpesviruses is high and reactivations occur frequently. a microarray was designed and tested for the detection of igg and igm antibodies for puumala hantavirus (puuv) and igg antibodies against four herpesviruses. initially, a microarray platform was set up using an unrelated in-house antigen, puuv recombinant nucleocapsid protein, to optimize the protocol for the detection of antibodies. detection of the four herpesviruses was set up in a microarray using the recom ... | 2009 | 19477202 |
| prevalence and clinical consequences of herpes simplex virus type 1 dna in human cornea tissues. | we determined the prevalence and clinical consequences of herpes simplex virus (hsv) type 1 (hsv-1), hsv type 2 (hsv-2), and varicella-zoster virus (vzv) in cornea tissues obtained after penetrating keratoplasty (pkp) was performed. | 2009 | 19476433 |
| incident hiv and herpes simplex virus type 2 infection among men in rakai, uganda. | herpes simplex virus type 2 (hsv-2) infection is associated with an increased risk for acquiring hiv, but little is known about the temporal sequence of these infections. | 2009 | 19474649 |
| bacterial vaginosis in female facility workers in north-western tanzania: prevalence and risk factors. | to determine prevalence of, and risk factors for, bacterial vaginosis (bv) among herpes simplex virus (hsv) 2 seropositive tanzanian women at enrollment into a randomised, placebo-controlled trial of hsv suppressive treatment. | 2009 | 19473997 |
| global burden of herpes simplex type 2. | 2009 | 19467471 | |
| [diagnostics of genital herpesvirus infection in women with tubal-peritoneal infertility]. | optimization of diagnostics of genital herpesvirus infection (herpes simplex virus types 1 and 2, cytomegalovirus [cmv]) in women with tubal-peritoneal infertility on the basis of detection of viral material in various parts of genital system using polymerase chain reaction (pcr) and revealing pathogenetically significant systemic abnormalitites of cytokine- and nitroxidergic regulation. | 2009 | 19459485 |
| social and behavioral correlates of sexually transmitted infection- and hiv-discordant sexual partnerships in bushwick, brooklyn, new york. | the centers for disease control and prevention (cdc) advise repeat hiv testing for partners of hiv-infected persons; injection drug users and their sex partners; individuals with recent multiple partnerships and their sex partners; those involved in sex trade; and men who have sex with men. additional social and behavioral variables may be useful for identifying priority populations. | 2009 | 19458533 |
| a prospective study of risk factors for herpes simplex virus type 2 acquisition among high-risk hiv-1 seronegative women in kenya. | several studies have demonstrated an association between herpes simplex virus type 2 (hsv-2) and hiv-1, but available data on risk factors for hsv-2 acquisition are limited. the objective of this analysis was to determine the incidence and risk factors for hsv-2 acquisition among hiv-1-seronegative female sex workers in kenya. | 2009 | 19457873 |
| genital herpes. | genital herpes is an infection with herpes simplex virus type 1 (hsv-1) or type 2 (hsv-2), and is among the most common sexually transmitted diseases. methods and outcomes: we conducted a systematic review and aimed to answer the following clinical questions: what are the effects of interventions to prevent sexual transmission of herpes simplex virus? what are the effects of interventions to prevent transmission of herpes simplex virus from mother to neonate? what are the effects of antiviral tr ... | 2007 | 19454063 |
| [culture of hsv-2 and cloning of specific fragment of the gg-2 gene]. | to clone the glycoprotein g gene and its specific fragment with high conservation and antigenicity by culturing and amplifying herpes simplex virus type 2 and extracting its whole genome. | 2009 | 19452693 |
| [benign recurrent lymphocytic meningitis from herpes simplex virus type 2]. | 2009 | 19445858 | |
| therapeutic effect of meliacine, an antiviral derived from melia azedarach l., in mice genital herpetic infection. | since natural products are considered powerful sources of novel drug discovery, a partially purified extract (meliacine) from the leaves of melia azedarach l., a plant used in traditional medicine in india for the treatment of several diseases, has been studied. meliacine exhibits a potent antiviral effect against several viruses without displaying cytotoxicity. the purpose of the present study was to evaluate the therapeutic effect of intravaginal administration of meliacine in a mouse model of ... | 2009 | 19441066 |
| disentangling contributions of reproductive tract infections to hiv acquisition in african women. | : to estimate the effects of reproductive tract infections (rtis) on hiv acquisition among zimbabwean and ugandan women. | 2009 | 19434010 |
| analysis of varicella-zoster virus and herpes simplex virus in various clinical samples by the use of different pcr assays. | rapid and reliable detection of varicella-zoster virus (vzv) and herpes simplex virus type 1 (hsv-1) and -2 (hsv-2) is of clinical significance in immunocompromised patients and patients with infections of the central nervous system. this paper describes the detection of vzv and hsv using the commercially available affigene vzv and affigene hsv 1/2 tracer kits in comparison to "in-house" polymerase chain reaction (pcr) assays. for sample preparation, qiagen (hilden, germany) and affigene (cephei ... | 2009 | 19433110 |
| an exopolysaccharide produced by geobacillus thermodenitrificans strain b3-72: antiviral activity on immunocompetent cells. | the immunomodulatory and antiviral effects of an extracellular polysaccharide (eps-2), produced by a strain of geobacillus thermodenitrificans isolated from a shallow marine vent of vulcano island (italy), were evaluated. in the present study, we show for the first time that eps-2 treatment hinder hsv-2 replication in human peripheral blood mononuclear cells (pbmc) but not in wish cells. in fact, high levels of ifn-alpha, il-12, ifn-gamma, tnf-alpha, il-18 were detected in supernatants of eps-2 ... | 2009 | 19428560 |
| the herpes simplex virus-induced demise of keratinocytes is associated with a dysregulated pattern of p63 expression. | p63 plays a pivotal role in the development and maintenance of stratified epithelial tissues. in an effort to gain insight into the pathogenic mechanisms of skin infections caused by hsv-1 and hsv-2, we determined the patterns of p63 expression in primary keratinocytes and in the hacat cell line. the levels of deltanp63alpha and a 50kda p73 isoform were decreased, bax-alpha remained unaffected, while the expressions of the bax-beta, tap63gamma and a 44.5kda p73 isoform were highly increased in b ... | 2009 | 19427396 |
| in vitro anti-herpetic activity of an aqueous extract from the plant phyllanthus orbicularis. | the herpesviridae includes at least eight viral species pathogenic for humans, responsible for a wide variety of clinical symptoms. the lack of an effective vaccine and the moderate to high toxicity of the available synthetic anti-herpes compounds emphasises the need for new inhibitors. several phyllanthus genus (euphorbiaceae) members have been widely used in traditional medicine and their biological properties have been intensely studied. in this study we investigated the in vitro antiviral ac ... | 2009 | 19423312 |
| isolation of sulfated galactan from codium fragile and its antiviral effect. | a sulfated galactan (fg) was isolated from the green alga, codium fragile. chemical analysis revealed that fg mainly consisted of d-galactose with pyruvic acid (12.3%) and sulfate (11.0%). methylation and nmr analyses showed that fg was composed of -->3)-beta-d-galp-(1-->, beta-d-galp-(1--> and -->3,6)-beta-d-galp-(1--> residue. in addition, pyruvic acid was suggested to be present as (1'-carboxy)-ethylidene cyclic ketal at o-3 and o-4 of non-reducing terminal galactose residues, whereas sulfate ... | 2009 | 19420760 |
| polymorphisms of mtdna control region in tunisian and moroccan populations: an enrichment of forensic mtdna databases with northern africa data. | current forensic mitochondrial (mt)dna databases are limited in representative population data of african origin. we investigated hvs-i/hvs-ii sequences of 120 tunisian and moroccan healthy male donors applying stringent quality criteria to assure high quality of the data and phylogenetic alignment and notation of the sequences. among 64 tunisians, 56 different haplotypes were observed and the most common haplotype (16187t 16189c 16223t 16264t 16270t 16278t 16293g 16311c 73g 152c 182t 185t 195c ... | 2009 | 19414164 |
| phosphonate analogues of cyclopropavir phosphates and their e-isomers. synthesis and antiviral activity. | z- and e-phosphonate analogues 12 and 13 derived from cyclopropavir and the corresponding cyclic phosphonates 14 and 15 were synthesized and their antiviral activity was investigated. the 2,2-bis(hydroxymethylmethylenecyclopropane acetate (17) was transformed to tetrahydropyranyl acetate 18. deacetylation gave intermediate 19 which was converted to bromide 20. alkylation with diisopropyl methylphosphonate afforded after protecting group exchange (21 to 22) acetylated phosphonate intermediate 22. ... | 2009 | 19410465 |
| does psychosocial stress predict symptomatic herpes simplex virus recurrence? a meta-analytic investigation on prospective studies. | previous psychological studies have paid extensive attention to the association between psychosocial stress and symptomatic herpes simplex virus (hsv) recurrence, but subsequent research has been conducted and conflicting findings have been published. we aimed to quantify the longitudinal association between psychosocial stress and recurrent hsv in the contemporary literature. we searched medline; psycinfo; web of science; pubmed up to march 2009, and included prospective studies that investigat ... | 2009 | 19409481 |
| characteristics of hiv-1 discordant couples enrolled in a trial of hsv-2 suppression to reduce hiv-1 transmission: the partners study. | the partners hsv-2/hiv-1 transmission study (partners study) is a phase iii, placebo-controlled trial of daily acyclovir for genital herpes (hsv-2) suppression among hiv-1/hsv-2 co-infected persons to reduce hiv-1 transmission to their hiv-1 susceptible partners, which requires recruitment of hiv-1 serodiscordant heterosexual couples. we describe the baseline characteristics of this cohort. | 2009 | 19404392 |
| meta-analytical studies on the epidemiology, prevention, and treatment of human immunodeficiency virus infection. | since the beginning of the epidemic, extensive research has been conducted in the field of hiv infection. original research and subsequent meta-analyses have contributed to a better understanding of the disease. epidemiologic research has shown, for example, that male circumcision reduces the risk of female-to-male transmission. nevertheless, the question whether circumcision confers protection against hiv transmission in msm remains open. studies have shown a positive correlation between hiv an ... | 2009 | 19393910 |
| pediatric herpes simplex virus keratitis. | to report the clinical characteristics and visual outcomes of pediatric herpes simplex virus (hsv) keratitis. | 2009 | 19387223 |
| high hiv and ulcerative sexually transmitted infection incidence estimates among men who have sex with men in peru: awaiting for an effective preventive intervention. | in the andean region, hiv and sexually transmitted infections (sti) are most prevalent among men who have sex with men (msm), but incidence estimates and associated factors have never been prospectively assessed. | 2009 | 19384102 |
| multiple viral genome search in endolabyrinthic fluids of profoundly deaf patients: possible cytomegalovirus intracochlear reactivation. | the cause of about 30% of bilateral sensorineural hearing loss (snhl) is still unknown. a viral etiology is among the most frequently proposed ones and the supposed diagnosis is only based upon few clinical and laboratory data. the detection of viral presence within a damaged compartment may represent a way to supply interesting data for confirmation of viral etiology and to explain pathogenic mechanisms. | 2009 | 19372646 |
| comparative performance of a novel herpes simplex virus type 2-specific enzyme-linked immunosorbent assay using a targeted chain oligopeptide, peptide 55. | herpes simplex virus (hsv) glycoprotein g (gg2) has been used as the basis of many serological assays for the detection of hsv type 2 (hsv-2)-specific antibodies. in the present study, an enzyme-linked immunosorbent assay (elisa), the pathozyme viro hsv-2 immunoglobulin g (igg) elisa (omega diagnostics, alva, united kingdom), based on an immunodominant epitope of gg2 presented in a branched-chain format (peptide 55), was compared with two commercially available gg2-specific assays, the bioelisa ... | 2009 | 19369475 |
| circumcision's place in the vicious cycle involving herpes simplex virus type 2 and hiv. | 2009 | 19367793 | |
| estimating the public health impact of the effect of herpes simplex virus suppressive therapy on plasma hiv-1 viral load. | trials of herpes simplex virus (hsv) suppressive therapy among hsv-2/hiv-1-infected individuals have reported an impact on plasma hiv-1 viral loads (pvls). our aim was to estimate the population-level impact of suppressive therapy on female-to-male hiv-1 sexual transmission. | 2009 | 19367154 |
| [the influence of chronic viral infections on tuberculosis]. | the influence of chronic viral infections (cvi) on tuberculosis (tb) was investigated in 117 patients with mix infection (hhv-2 - human herpes virus-2) and tb; 6 patients with mix infection (cmv - cytomegalovirus) and tb; 22 patients with mix infection (individuals with chronic hepatitis c virus (hcv) infection and tb. the control group was composed of 33 tb patients without cvi. increased rates of atypical tuberculosis, reactivation of latent tuberculosis have been reported among patients with ... | 2009 | 19359724 |
| prevention of genital herpes simplex virus type 1 and 2 disease in mice immunized with a gd-expressing dominant-negative recombinant hsv-1. | cj9-gd is a novel herpes simplex virus (hsv) type 1 recombinant virus that is completely replication-defective, expresses high-levels of hsv-1 major antigen glycoprotein d (gd), and can function in trans to inhibit replication of wild-type hsv-1 and hsv-2 in co-infected cells. here, we show that immunization with cj9-gd elicits strong and long-lasting humoral and th1-like cellular immune responses against both hsv-1 and hsv-2. mice immunized with cj9-gd exhibited significant reductions in the ex ... | 2009 | 19357711 |
| simultaneous identification of 14 genital microorganisms in urine by use of a multiplex pcr-based reverse line blot assay. | the aim of this study was to develop and evaluate a sensitive method for the simultaneous identification of 14 urogenital potential pathogens. a multiplex pcr-based reverse line blot (mpcr/rlb) assay was developed to detect 14 urogenital pathogens or putative pathogens, namely trichomonas vaginalis, streptococcus pneumoniae, neisseria gonorrhoeae, chlamydia trachomatis, ureaplasma parvum, u. urealyticum, gardnerella vaginalis, haemophilus influenzae, herpes simplex virus type 1 (hsv1) and hsv2, ... | 2009 | 19357202 |
| unusually high hiv infectiousness in an hiv-, hcv- and hsv-2-coinfected heterosexual man. | we report an hiv-hcv-hsv-2-coinfected man, who infected all of five sequential female sexual partners within seven years. hiv-rna in semen was unusually high and exceeded that in plasma by one log10. screening for sexually transmitted diseases remained negative with the exception of hsv-2-seropositivity. recurrent asymptomatic genital herpes might explain the patient's increased hiv-rna shedding in semen. | 2009 | 19350427 |
| herpes simplex. | after completing this article, readers should be able to: 1. characterize the epidemiology of herpes simplex virus (hsv) infection, including mode of transmission, incubation period, and period of communicability. 2. recognize the difference in clinical manifestations of hsv1 and hsv2 infection. 3. diagnose various manifestations of hsv infection. 4. describe the difference in the clinical manifestations and outcome of hsv infection in newborns and older infants and children. 5. discuss the mana ... | 2009 | 19339385 |
| seroprevalence and factors associated with herpes simplex virus type 2 among hiv-negative high-risk men who have sex with men from rio de janeiro, brazil: a cross-sectional study. | herpes simplex virus type 2 (hsv-2) is the leading cause of genital ulcer disease in developing countries, including brazil, and is especially prevalent among men who have sex with men (msm). hsv-2 infection represents a risk factor for the acquisition and transmission of other sexually transmitted diseases. the goal of the present cross-sectional study was to estimate hsv-2 seroprevalence and to determine the factors associated with hsv-2 seropositivity in hiv-negative high-risk msm from rio de ... | 2009 | 19335922 |
| sexually transmitted diseases diagnosed among travelers returning from the tropics. | data are lacking on the spectrum of sexually transmitted diseases (stds) diagnosed in returning travelers. | 2009 | 19335805 |
| seroprevalence of kaposi sarcoma-associated herpesvirus and other serologic markers in the brazilian amazon. | to determine the presence of kaposi sarcoma-associated herpesvirus (kshv) and other serologic markers, we tested serum specimens of 339 amerindians, 181 rural non-amerindians, and 1,133 urban blood donors (13 amerindians) in the brazilian amazon. high kshv seroprevalence in children and inverse association with herpes simplex virus type 2 indicates predominant nonsexual transmission among amerindians. | 2009 | 19331768 |
| prospective study of correlates of vaginal lactobacillus colonisation among high-risk hiv-1 seronegative women. | vaginal colonisation with lactobacillus species is characteristic of normal vaginal ecology. the absence of vaginal lactobacilli, particularly hydrogen peroxide (h(2)o(2))-producing isolates, has been associated with symptomatic bacterial vaginosis (bv) and increased risk for hiv-1 acquisition. identification of factors associated with vaginal lactobacillus colonisation may suggest interventions to improve vaginal health. | 2009 | 19329442 |
| herpes simplex virus type 2 (mollaret's) meningitis: a case report. | mollaret's meningitis is an unusual and under-appreciated syndrome of benign, recurrent aseptic meningitis. the available literature indicates that the causative agent is herpes simplex virus type 2 (hsv-2) in the majority of cases and much less frequently herpes simplex virus type 1 (hsv-1). | 2009 | 19329344 |
| child sexual abuse and persistence of risky sexual behaviors and negative sexual outcomes over adulthood: findings from a birth cohort. | to determine the impact of child sexual abuse (csa) on adult sexual behaviors and outcomes over three age periods. | 2009 | 19327837 |
| herpesviruses in chronic and aggressive periodontitis patients in an indian population. | many recent studies have assessed the prevalence and role of herpesviruses in the etiopathogenesis of periodontal diseases, which has led to the realization of intricate interactions between viruses and bacteria within periodontal pockets. it has also been shown that the occurrence of herpesviruses may vary depending upon the age of the patient and the race of the population studied. thus, the present study aimed at detecting herpes simplex virus type 1 and 2 (hsv 1 and 2), epstein-barr virus (e ... | 2009 | 19325203 |