Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| effects of hiv-1 and herpes simplex virus type 2 infection on lymphocyte and dendritic cell density in adult foreskins from rakai, uganda. | male circumcision reduces human immunodeficiency virus (hiv) and herpes simplex virus type 2 (hsv-2) acquisition, and hsv-2 infection is associated with an increased risk of hiv acquisition. to assess the cellular basis for these associations, we estimated immunologic cellular densities in foreskin tissue. | 2011 | 21220779 |
| in vitro anti-herpes simplex virus activity of 1,2,4,6-tetra-o-galloyl-β-d-glucose from phyllanthus emblica l. (euphorbiaceae). | in this study, 1,2,4,6-tetra-o-galloyl-β-d-glucose (1246tgg), a polyphenolic compound isolated from traditional chinese medicine phyllanthus emblica l. (euphorbiaceae), was found to inhibit herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) infection at different magnitudes of activity in vitro. further studies revealed that 1246tgg directly inactivated hsv-1 particles, leading to the failure of early infection, including viral attachment and penetration. 1246tgg also suppressed the intracel ... | 2011 | 21213355 |
| vitamin d status and antibody levels to common viruses in pediatric-onset multiple sclerosis. | the relative contribution and interaction of risk factors for multiple sclerosis (ms) have not been evaluated. objectives: to determine whether vitamin d status is associated with antibody levels to common viruses in pediatric-onset ms or clinically isolated syndrome (cis) patients and controls. | 2011 | 21212086 |
| genital ulcer disease treatment policies and herpes. | 2011 | 21209599 | |
| fulminant hepatitis following primary herpes simplex virus infection. | fulminant hepatic failure (fhf) is a rare but well-recognized complication of primary herpes simplex virus (hsv) infection in immunocompromised patients. here, we report two cases of acute hepatitis and fhf secondary to primary hsv type 1 infection following renal transplantation in the absence of any mucocutaneous manifestation. high levels of hsv type-1 dna were detected in the blood. both patients were seronegative for hsv 1 and hsv 2 immunoglobulin g (igg) before transplantation, whereas the ... | 2011 | 21196623 |
| expression of the hsv-1 capsid protein vp19c in escherichia coli: a single amino acid change overcomes an expression block of the full-length polypeptide. | the herpesvirus triplex is a key structural feature of the capsids of these viruses. it is composed of a hetero-trimer of one molecule of vp19c and two molecules of vp23. it acts to stabilize capsid shells by connecting the capsomeric subunits together. although it has been possible to over-express in escherichia coli and purify one component of the triplex, vp23; this has not been the case with vp19c. because an n-terminal polypeptide of vp19c could be expressed and purified using a gst affinit ... | 2010 | 21193049 |
| pseudoepitheliomatous hyperplasia mimicking vulvar cancer in a patient with aids. | pseudoepitheliomatous hyperplasia (peh) clinically and histologically mimics squamous cell carcinoma (scc), specifically in patients with hiv and aids. | 2011 | 21192180 |
| rare and deadly. | 2011 | 21187183 | |
| [study on the inhibition effect of sirna on herpes simplex virus type 2 icp4 gene]. | to explore the inhibition effect of rna interference on the icp4 expression and dna replication of herpes simplex virus type 2 (hsv2). | 2010 | 21186526 |
| characteristics associated with genital herpes testing among young adults: assessing factors from two national data sets. | objectives and participants: in the united states, genital herpes (gh) prevalence is 10.6% among 20- to 29-year-olds and about 90% of seropositive persons do not know their status. this study investigated individual characteristics associated with gh screening and diagnosis in sexually active young adults aged 18 to 24. | 2010 | 21186443 |
| antiviral drug resistance and helicase-primase inhibitors of herpes simplex virus. | a new class of chemical inhibitors has been discovered that interferes with the process of herpesvirus dna replication. to date, the majority of useful herpesvirus antivirals are nucleoside analogues that block herpesvirus dna replication by targeting the dna polymerase. the new helicase-primase inhibitors (hpi) target a different enzyme complex that is also essential for herpesvirus dna replication. this review will place the hpi in the context of previous work on the nucleoside analogues. seve ... | 2010 | 21183396 |
| lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza a virus infection. | mannose-binding lectin (mbl), a pattern recognition innate immune molecule, inhibits influenza a virus infection in vitro. mbl deficiency due to gene polymorphism in humans has been associated with infection susceptibility. these clinical observations were confirmed by animal model studies, in which mice genetically lacking mbl were susceptible to certain pathogens, including herpes simplex virus 2. | 2010 | 21182784 |
| prurigo pigmentosa: a clinicopathological study and analysis of associated factors. | prurigo pigmentosa (pp), a rare inflammatory disease of the skin, is mostly reported in the ethnic japanese population. its pathogenesis remains unclear. the chronic and recurrent nature of pp implies a possible role of viral infection in the pathogenesis. the anti-inflammatory mechanism of doxycycline, which is well documented as a good treatment for pp, is related to the suppression of interleukin expression. | 2011 | 21182500 |
| multiplex pcr for identification of herpes virus infections in adolescents. | the aim of the study was to develop a multiplex pcr (mpcr) for a rapid and simultaneous detection of herpes simplex 1 (hsv-1), herpes simplex 2 (hsv-2), and human cytomegalovirus (hcmv) dna in squamous oral cells obtained from adolescents. accuracy of the method was tested in a group of 513 adolescents, almost 11% of subjects were positive for infection with herpes viruses. correlations with gender, age, and place of residence were sought. a similar incidence of hsv-2 and hcmv was found (4.3% an ... | 2011 | 21181921 |
| testing of herpes simplex virus for resistance to antiviral drugs. | herpes simplex virus (hsv) infections can be treated efficiently by the application of antiviral compounds. several drugs on the basis of acyclovir (acv), penciclovir (pcv) and foscarnet (fos) have been approved. resistant viral isolates can be observed especially in immunocompromised patients, who are treated with antivirals for long time intervals. that is why methods for analysis of hsv resistance to antiviral drugs have to be available in virological laboratories. we analyzed hsv type 1 (hsv ... | 2010 | 21178503 |
| subcellular localization of the alphaherpesvirus serine/threonine kinase us3 as a determinant of us3 function. | the us3 serine threonine kinases perform multiple roles in alphaherpesvirus infection and can localize to distinct subcellular compartments. transient expression of us3 in cells results in two dramatic alterations of the actin cytoskeleton: production of actin-based filamentous processes (fps); and breakdown of actin stress fibres giving rise to rounded cell morphology. in our recent study on fps induced by hsv-2 us3, we noted that fp formation was diminished when hsv-2 us3 was trapped within th ... | 2010 | 21178457 |
| herpes simplex virus type 2 seropositivity and relationship status among u.s. adults age 20 to 49: a population-based analysis. | u.s. population studies show herpes simplex virus type 2 (hsv-2) seroprevalence levelling by approximately age 30, suggesting few new infections after that age. it is unclear whether this pattern is driven by greater percentages in stable relationships, and to what extent adults who initiate new relationships may be at risk of incident hsv-2 infection. | 2010 | 21176214 |
| keratinocytes play a role in the immunity to herpes simplex virus type 2 infection. | herpes simplex virus type 2 (hsv-2) infection is the most common cause of genital ulcerative disease in the developed world. keratinocytes are the primary cells involved in clinical lesions caused by hsv-2. in our study, we intensively examined cytokine expression in the hsv-2-infected keratinocytes. we observed upregulation of a series of cytokines including early-induced antiviral cytokines as interferons α, β (ifn-α, β), tumor necrosis factor α (tnf-α), colony stimulating factors (csfs) as g- ... | 2010 | 21175248 |
| recruited inflammatory monocytes stimulate antiviral th1 immunity in infected tissue. | monocytes patrol various tissues for signs of infection and inflammation. inflammatory monocytes enter peripheral tissues at sites of microbial infection and differentiate into dendritic cells and macrophages. here, we examined the importance of monocytes in primary mucosal infection with herpes simplex virus 2 (hsv-2), and demonstrate that monocyte-derived apcs are required to elicit ifn-γ secretion from effector th1 cells to mediate antiviral protection. however, monocyte-derived apcs were dis ... | 2010 | 21173243 |
| herpes simplex virus colitis complicating ulcerative colitis: a case report and brief review on superinfections. | in patients with inflammatory bowel disease herpes simplex virus infection has been described as a major cause of morbidity and mortality, especially in immunocompromised individuals. here we present the case of a 35-year old woman with an exacerbation of ulcerative colitis caused by herlpes simplex virus infection (hsv-2). the diagnosis was confirmed histologically following subtotal colectomy. after intravenous treatment with aciclovir for 2 weeks postoperative hematochezia stopped. herpes sim ... | 2007 | 21172183 |
| in vitro anti hsv-1 and hsv-2 activity of tanacetum vulgare extracts and isolated compounds: an approach to their mechanisms of action. | herpes simplex viruses (hsv-1 and hsv-2) are responsible for long-term latent infections in humans, with periods of recurring viral replication associated to lesions around the lips, eyes, mucous membrane of the oral cavity or the genitals. the lack of an effective vaccine, the moderate to high toxicity of the available synthetic antiherpes compounds and the appearance of resistant viral strains emphasize the need for new inhibitors. tanacetum vulgare, commonly known as tansy, has been used for ... | 2010 | 21171142 |
| bilateral herpes simplex-2 acute retinal necrosis with encephalitis in premature twins. | acute retinal necrosis, caused by the herpes family of viruses, is a rapidly progressing ocular inflammatory disorder commonly reported in adults but rarely in children. the accepted diagnostic criteria include presence of 1 or more foci of retinal necrosis, rapid progression, circumferential spread, occlusive vasculopathy, and inflammation in the vitreous and anterior chamber. we report bilateral acute retinal necrosis with encephalitis due to herpes simplex virus (hsv-2) in newborn twins. | 2010 | 21168079 |
| spread of herpes simplex virus to the spinal cord is independent of spread to dorsal root ganglia. | levels of herpes simplex virus 1 (hsv-1) and hsv-2 dna in dorsal root ganglia (drg) and spinal cord (sc) were quantified after inoculation of guinea pig genitals and footpads. in genital infection, viral dna reached sc and drg simultaneously (at 2 to 3 days after inoculation) but was more abundant in sc than in drg. after inoculation of footpads, which lack parasympathetic innervation, the viruses spread more efficiently to drg than to sc. these results show important differences between genital ... | 2010 | 21159869 |
| prevention of neonatal herpes. | neonatal herpes can occur when the neonate is exposed to herpes simplex virus in the maternal genital tract during labour. attack rates are highest when the mother has a newly acquired infection and, therefore, does not have antibodies to protect the neonate. even with early therapy, there is significant morbidity and mortality associated with neonatal herpes, suggesting that preventing neonatal herpes simplex virus exposure or early recognition of exposure is important. the incidence of neonata ... | 2011 | 21159118 |
| dermacase. can you identify this condition? genital herpes. | 2010 | 21156897 | |
| sexually transmitted infections among pakistani pregnant women and their husbands in norway. | to assess frequency and determine the factors associated with chlamydia trachomatis, herpes simplex virus type 2, and hepatitis b seropositivity among pakistani pregnant women and their husbands in norway. | 2010 | 21151677 |
| no impact of oral tenofovir disoproxil fumarate on herpes simplex virus shedding in hiv-infected adults. | to determine the impact of oral tenofovir as part of combination antiretroviral therapy on asymptomatic herpes simplex virus (hsv) shedding. | 2011 | 21150556 |
| serological immunity to adenovirus serotype 5 is not associated with risk of hiv infection: a case-control study. | adenoviruses are among the most promising vectors for the development of an hiv vaccine. the results of the phase iib study of the adenovirus serotype 5-based merck trivalent hiv vaccine have raised the concern that serological immunity to adenovirus serotype 5 (ad5) could be linked to hiv acquisition risk in high-risk individuals. we examined the association between adenovirus serostatus and the rate of incident hiv infection in populations at elevated risk of hiv acquisition. | 2011 | 21150554 |
| reduction of herpes simplex virus type-2 replication in cell cultures and in rodent models with peptide-conjugated morpholino oligomers. | genital herpes, caused by herpes simplex virus type-2 (hsv-2), is a recurrent, lifelong disease affecting tens of millions of people in the usa alone. hsv-2 can be treated therapeutically with acyclovir (acv) and its derivatives; however, no treatment can prevent hsv reactivation. novel topical anti-hsv microbicides are much needed to reduce hsv-2 transmission and to treat primary or reactivated infections, especially for acv-resistant strains. peptide-conjugated phosphorodiamidate morpholino ol ... | 2010 | 21149921 |
| crystal structure of the epstein-barr virus (ebv) glycoprotein h/glycoprotein l (gh/gl) complex. | the epstein-barr virus (ebv) is a γ-herpesvirus that infects b cells and epithelial cells and that has been linked to malignancies in both cell types in vivo. ebv, like other herpesviruses, has three glycoproteins, glycoprotein b (gb), gh, and gl, that form the core membrane fusion machinery mediating viral penetration into the cell. the gh and gl proteins associate to form a heterodimeric complex, which is necessary for efficient membrane fusion and also implicated in direct binding to epitheli ... | 2010 | 21149717 |
| structure of a core fragment of glycoprotein h from pseudorabies virus in complex with antibody. | compared with many well-studied enveloped viruses, herpesviruses use a more sophisticated molecular machinery to induce fusion of viral and cellular membranes during cell invasion. this essential function is carried out by glycoprotein b (gb), a class iii viral fusion protein, together with the heterodimer of glycoproteins h and l (gh/gl). in pseudorabies virus (prv), a porcine herpesvirus, it was shown that gh/gl can be substituted by a chimeric fusion protein gdgh, containing the receptor bind ... | 2010 | 21149698 |
| herpes simplex virus type 2 suppressive therapy with acyclovir or valacyclovir does not select for specific hiv-1 resistance in hiv-1/hsv-2 dually infected persons. | recent in vitro studies suggest that acyclovir may directly inhibit hiv-1 replication and can select for a specific hiv-1 reverse transcriptase mutation (v75i) with concomitant loss of an anti-hiv-1 effect. we tested for hiv-1 genotypic resistance at reverse transcriptase codon 75 in plasma from 168 hiv-1-infected persons from botswana, kenya, peru, and the united states taking daily acyclovir or valacyclovir for between 8 weeks and 24 months. no v75i cases were detected (95% confidence interval ... | 2011 | 21148504 |
| loss of the type i interferon pathway increases vulnerability of mice to genital herpes simplex virus 2 infection. | the mouse model of genital herpes relies on medoxyprogesterone treatment of female mice to render the vaginal lumen susceptible to inoculation with herpes simplex virus 2 (hsv-2). in the present study, we report that mice deficient in the a1 chain of the type i interferon receptor (cd118(-/-)) are susceptible to hsv-2 in the absence of medroxyprogesterone preconditioning. in the absence of hormone pretreatment, 2,000 pfu of a clinical isolate of hsv-2 was sufficient to establish a productive inf ... | 2010 | 21147921 |
| characterization, molecular cloning, and in silico analysis of a novel mannose-binding lectin from polygonatum odoratum (mill.) with anti-hsv-ii and apoptosis-inducing activities. | polygonatum odoratum lectin (pol), a novel mannose-binding lectin with anti-viral and apoptosis-inducing activities, was isolated from rhizomes of polygonatum odoratum (mill.) druce. pol was a homo-tetramer with molecular weight of 11953.623da per subunits as determined by gel filtration, sds-page and mass spectrometry. based on its n-terminal 29-amino acid sequence the full-length cdna sequence of pol was cloned. subsequent phylogenetic analysis and molecular modeling revealed that pol belonged ... | 2010 | 21146383 |
| hpv-73- and hpv-82 positive anal margin carcinoma with secondary ulcerating herpes simplex-virus 2 infection. | 2010 | 21143394 | |
| inhibition of γ-secretase cleavage in the notch signaling pathway blocks hsv-2-induced type i and type ii interferon production. | we have evaluated the role of γ-secretase, which is a crucial component in the notch-induced signaling cascade, on herpes simplex virus type 2 (hsv-2)-induced innate and acquired interferon responses in human cd4(+) t cells and plasmacytoid dendritic cells (pdc). we found that blockade of the notch signaling pathway with a pharmacological γ-secretase inhibitor blocked both hsv-2-induced interferon-γ (ifn-γ) production in cd4(+) t cells, and hsv-2-induced ifn-α production in pdc in a dose-depende ... | 2010 | 21142451 |
| availability of serologic and virologic testing for herpes simplex virus in the largest sexually transmitted disease clinics in the united states. | background:: the prevalence of herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) in the united states is estimated to be 57.7% for hsv 1 and 17.0% for hsv 2. the centers for disease control and prevention recommends that both virologic and serologic tests be available at clinics that examined clients at risk for sexually transmitted diseases. methods:: a telephone survey was conducted. providers at the 230 largest sexually transmitted disease clinics in the united states were surveyed regar ... | 2010 | 21139516 |
| prevalence and risk factors for sexually transmitted infections in a high-risk occupational group: the case of fishermen along lake victoria in kisumu, kenya. | the aim of this study was to assess prevalence and risk factors for sexually transmitted infections (stis) among fishermen along lake victoria, kenya. this cross-sectional study surveyed 250 fishermen from beaches in kisumu district using proportional-to-size sampling based on the number of registered boats per beach. participants provided demographic and sexual behaviour information, blood for hiv-1 herpes simplex virus type 2 (hsv-2) and syphilis serological tests urine for transcription-media ... | 2010 | 21139150 |
| a mucosal vaccination approach for herpes simplex virus type 2. | an estimated 1 out of every 5 americans is infected with herpes simplex virus type 2 (hsv-2). efforts in developing a potent vaccine for hsv-2 have shown limited success. here we describe a heterologous vaccination strategy for hsv-2 based on an intramuscular dna prime followed by a liposome-encapsulated antigen boost delivered intranasally. both portions of the vaccine express the immunogenic hsv-2 glycoprotein d. in female balb/c mice, this heterologous immunisation regimen stimulated high tit ... | 2010 | 21134447 |
| three-dimensional analysis of combination effect of ellagitannins and acyclovir on herpes simplex virus types 1 and 2. | the effects of combinations of three nonahydroxyterphenoyl-bearing c-glucosidic ellagitannins (castalagin, vescalagin and grandinin) with acyclovir (acv) on the replication of type-1 and type-2 herpes simplex viruses in mdbk cells were tested by the focus-forming units reduction test. ellagitannins included in these combinations possess a high individual antiviral activity: selectivity index of castalagin and vescalagin versus hsv-1 was similar to that of acv, and relatively lower against hsv-2. ... | 2010 | 21134403 |
| a case of recurrent benign lymphocytic (mollaret's) meningitis and review of the literature. | mollaret's meningitis is a rare form of benign recurrent aseptic meningitis first described in 1944. we report a case of mollaret's meningitis due to herpes simplex virus type 2 (hsv2), diagnosed with polymerase chain reaction (pcr) implementation in the cerebrospinal fluid (csf) of the patient and treated successfully with acyclovir. to our knowledge, this is the first case of mollaret's meningitis reported in greece. we reviewed the literature since pcr has become widely available. herpes simp ... | 2010 | 21126724 |
| impact of valency of a glycoprotein b-specific monoclonal antibody on neutralization of herpes simplex virus. | herpes simplex virus (hsv) glycoprotein b (gb) is an integral part of the multicomponent fusion system required for virus entry and cell-cell fusion. here we investigated the mechanism of viral neutralization by the monoclonal antibody (mab) 2c, which specifically recognizes the gb of hsv type 1 (hsv-1) and hsv-2. binding of mab 2c to a type-common discontinuous epitope of gb resulted in highly efficient neutralization of hsv at the postbinding/prefusion stage and completely abrogated the viral ... | 2010 | 21123390 |
| [development of a novel real-time pcr method for detection of hsv types 1 and 2 dna using hybprobe chemistry]. | herpes simplex viruses types 1 and 2 are members of the alphaherpesviridae subfamily, as they can infect both skin and nerves and develop latent infection within the dorsal root and trigeminal ganglia. infections with these viruses are common worldwide and cause wide range of clinical syndromes. although hsv-1/2 infect healthy children and adults, disease is more severe and extensive in the immunocompromised individuals and/or during neuroinfections. the aim of the study was development of real- ... | 2010 | 21114018 |
| acute retinal necrosis after herpetic encephalitis. | purpose: to report a case of unilateral acute retinal necrosis after herpetic encephalitis case report: a young man was referred with a chief complaint of blurred vision and pain of the left eye 1 month after herpetic encephalitis in the left frontotemporal lobe. the patient had multiple foci of retinitis in the retinal periphery associated with vitritis, blot retinal hemorrhage and retinal arteriolitis. the impression of acute retinal necrosis was confirmed by polymerase chain reaction of aqueo ... | 2010 | 21113344 |
| hsv-2 seroincidence among mexican college students: the delay of sexual debut is not enough to avoid risky sexual behaviours and virus transmission. | early sexual debut is a behaviour that has been associated with acquiring sexually transmitted infections. higher schooling may delay sexual debut, thus the university population is categorised with low-risk sexual behaviours. the rate ratio of herpes simplex virus type 2 (hsv-2) seroincidence according to demographic characteristics and sexual behaviour was estimated for a cohort of university students. | 2010 | 21113070 |
| novel approaches to vaginal delivery and safety of microbicides: biopharmaceuticals, nanoparticles, and vaccines. | the hiv-1 epidemic remains unchecked despite existing technology; vaccines and microbicides in development may help reverse the epidemic. reverse transcriptase inhibitors (rtis) formulated in gels tenofovir (tfv) and ivrs (dapivirine) are under clinical development. while tfv or similar products may prove successful for hiv-1, alternatives to rtis may provide additional benefits, e.g., broader sti prevention. biopharmaceutical agents under development as microbicides include cyanovirin, rantes a ... | 2010 | 21109069 |
| combining prevention of hiv-1, other sexually transmitted infections and unintended pregnancies: development of dual-protection technologies. | a significant number of women, especially in developing countries, need protection against more than one sexually transmitted infection (stis), for instance hiv-1 and hsv-2, and family planning methods to prevent unwanted pregnancies. dual protection technologies (dpts; also known as multipurpose technologies) are designed to address two different indications with one product. examples of dpts are vaginal products capable of preventing transmission of hiv-1 in women while simultaneously providin ... | 2010 | 21109068 |
| the ribonucleotide reductase r1 subunits of herpes simplex virus types 1 and 2 protect cells against tnfα- and fasl-induced apoptosis by interacting with caspase-8. | we previously reported that hsv-2 r1, the r1 subunit (icp10; ul39) of herpes simplex virus type-2 ribonucleotide reductase, protects cells against apoptosis induced by the death receptor (dr) ligands tumor necrosis factor-alpha- (tnfα) and fas ligand (fasl) by interrupting dr-mediated signaling at, or upstream of, caspase-8 activation. further investigation of the molecular mechanism underlying hsv-2 r1 protection showed that extracellular-regulated kinase 1/2 (erk1/2), phosphatidylinositol 3-ki ... | 2011 | 21107701 |
| sexually transmitted infections and hiv: epidemiology and interventions. | although the association of hiv and sexually transmitted infections (stis) has been well known for 25 years, there is insufficient attention to stis by many hiv providers, in part because patients are asymptomatic or have nonspecific symptoms and because of provider demands and focus. optimal patient care requires frequent testing for stis as well as obtaining an accurate medical history, which requires building trust with patients and asking direct but open-ended questions about risks and sympt ... | 2010 | 21107013 |
| can herpes simplex virus type 2 suppression slow hiv disease progression: a study protocol for the valacyclovir in delaying antiretroviral treatment entry (validate) trial. | although highly active antiretroviral therapy (haart) has dramatically decreased hiv-related morbidity and mortality, the associated costs, toxicities, and resistance risks make the potential delay of haart initiation an attractive goal. suppression of herpes simplex virus type 2 (hsv-2) may be a novel strategy for achieving this goal because hsv-2 is associated with clinically significant increases in hiv viral load, the primary driver of hiv disease progression. | 2010 | 21106086 |
| a post-trial assessment of factors influencing study drug adherence in a randomized biomedical hiv-1 prevention trial. | high adherence and maintenance of blinding are critical for placebo-controlled efficacy trials of hiv-1 biomedical prevention strategies. we assessed adherence to study drug and factors affecting adherence, including perceived randomization group, in a post-trial questionnaire of participants who completed hptn 039, a randomized, placebo-controlled trial of hsv-2 suppression with twice-daily acyclovir to reduce hiv-1 acquisition. of the 3172 trial participants, 2003 (63%) completed the post-tria ... | 2010 | 21104007 |
| male circumcision and risk of hiv acquisition among msm. | to assess the association between male circumcision, insertive anal sex practices, and hiv acquisition in a cohort of msm. | 2011 | 21099672 |
| projected cost-savings with herpes simplex virus screening in pregnancy: towards a new screening paradigm. | herpes simplex virus (hsv) infections in newborns are an uncommon but potentially devastating consequence of genital hsv infection in women. current practice focuses on preventing perinatal transmission by women with prevalent hsv, but transmission risk is greatest when genital hsv is acquired for the first time late in pregnancy. the objective of this study was to assess the effectiveness and cost effectiveness of identifying pregnant women at risk of de novo hsv acquisition as a means of preve ... | 2010 | 21097810 |
| high prevalence of hiv-1, hiv-2 and other sexually transmitted infections among women attending two sexual health clinics in bissau, guinea-bissau, west africa. | the objective was to examine the prevalence of hiv-1, hiv-2 and 10 other sexually transmitted infections (stis), and to explore the relationship between hiv and those stis in women attending two sexual health clinics in bissau, guinea-bissau. in all, 711 women with urogenital problems were included. clinical examination was performed and hiv-1, hiv-2, human t-cell lymphotropic virus (htlv)-1, htlv-2 and syphilis were diagnosed by serology. trichomonas vaginalis was examined using wet mount micro ... | 2010 | 21097735 |
| sensitivity and specificity of herpes simplex virus-2 serological assays among hiv-infected and uninfected urban ugandans. | herpes simplex virus type 2 (hsv-2) is a risk factor for hiv-1 infection. we characterized hsv-2 serology assay performance in hiv-positive and hiv-negative africans. serostatus for hsv-2 and hiv-1 was determined in 493 serum specimens stored from a community hsv-2 prevalence survey in kampala, uganda. hsv-2 serology by focus herpeselect elisa, biokit hsv-2 rapid assay and kalon hsv-2 was compared with hsv-2 western blot (wb) according to hiv-1 serostatus. sensitivity/specificity was: 99.5%/70.2 ... | 2010 | 21097732 |
| guidelines for the laboratory diagnosis of genital herpes in eastern european countries. | these guidelines aim to provide comprehensive information about sexually transmitted herpes simplex virus (hsv) infection and its laboratory diagnosis in eastern european countries. they are primarily intended for professionals testing specimens from patients at a sexual healthcare clinic but may also be helpful for community-based screening programmes. in particular, the guidelines recommend: (i) either viral culture or validated and approved nucleic acid amplification tests (naats) as the test ... | 2010 | 21087585 |
| microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse. | several active ingredients proposed as vaginal microbicides have been shown paradoxically to increase susceptibility to infection in mouse genital herpes (hsv-2) vaginal susceptibility models and in clinical trials. in addition, "inactive ingredients" (or excipients) used in topical products to formulate and deliver the active ingredient might also cause epithelial toxicities that increase viral susceptibility. however, excipients have not previously been tested in susceptibility models. | 2010 | 21087496 |
| genital herpes evaluation by quantitative taqman pcr: correlating single detection and quantity of hsv-2 dna in cervicovaginal lavage fluids with cross-sectional and longitudinal clinical data. | to evaluate the utility of a single quantitative pcr (qpcr) measurement of hsv (hsv-1&2) dna in cervicovaginal lavage (cvl) specimens collected from women with predominantly chronic hsv-2 infection in assessing genital hsv shedding and the clinical course of genital herpes (gh) within a cohort with semiannual schedule of follow up and collection of specimens. | 2010 | 21087488 |
| resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management. | herpes simplex viruses (hsv) type 1 and type 2 are responsible for recurrent orolabial and genital infections. the standard therapy for the management of hsv infections includes acyclovir (acv) and penciclovir (pcv) with their respective prodrugs valacyclovir and famciclovir. these compounds are phosphorylated by the viral thymidine kinase (tk) and then by cellular kinases. the triphosphate forms selectively inhibit the viral dna polymerase (dna pol) activity. drug-resistant hsv isolates are fre ... | 2010 | 21078929 |
| immune-based approaches to the prevention of mother-to-child transmission of hiv-1: active and passive immunization. | despite more than 2 decades of research, an effective vaccine that can prevent hiv-1 infection in populations exposed to the virus remains elusive. in the pursuit of an hiv-1 vaccine, does prevention of exposure to maternal hiv-1 in utero, at birth or in early life through breast milk require special consideration? this article reviews what is known about the immune mechanisms of susceptibility and resistance to mother-to-child transmission (mtct) of hiv-1 and summarizes studies that have used p ... | 2010 | 21078451 |
| prevalence, incidence, and persistence of syphilis infection in female sex workers in a chinese province. | summarythe study's objectives were to investigate the prevalence, incidence, persistence, and associated risk factors of syphilis in female sex workers (fsws) in kaiyuan city, yunnan, china. three serial cross-sectional surveys were conducted and biological specimens were collected and tested for hiv, sexually transmitted infections, and drug use. the logistic generalized estimating equation regression model was used to identify risk factors for prevalent syphilis. the prevalence of syphilis was ... | 2010 | 21073767 |
| seroprevalence of herpes simplex virus type 1 and type 2 among the indigenous population of cape york, far north queensland, australia. | the objective of this study was to obtain representative seroprevalence data for the indigenous population of far north queensland by measuring the age- and sex-specific seroprevalence of the herpes simplex viruses (hsv-1 and hsv-2) in cape york. | 2010 | 21062586 |
| prevalence and correlates of herpes simplex virus-2 and syphilis infections in the general population in india. | to determine the prevalence and correlates of herpes simplex virus-2 (hsv-2) and syphilis infections in the general population in india. | 2010 | 21059842 |
| modelling the interactions between herpes simplex virus type 2 and hiv: implications for the hiv epidemic in southern india. | the role of herpes simplex virus type 2 (hsv-2) in the hiv epidemic and the potential impact of hsv-2 suppressive therapy have previously been explored only within the context of sub-saharan africa. in this analysis, modelling is used to estimate the contribution of hsv-2 to hiv transmission from clients to female sex workers (fsw) in a southern indian setting and the maximum potential impact of 'perfect' hsv-2 suppressive therapy on hiv incidence. | 2010 | 21059838 |
| [prevalence and correlates of herpes simplex virus infections among aids patients in a county of shanxi province, china]. | to determine the prevalence of herpes simplex virus (hsv) and its correlates among hiv/aids patients in a county of shanxi. | 2010 | 21055128 |
| [evaluation of a dominant-negative recombinant herpes simplex virus (hsv) type 1 as a vaccine against genital herpes in mice und guinea pigs]. | genital herpes caused by herpes simplex virus (hsv) is one of the most common sexually transmitted diseases worldwide. currently, no safe and effective vaccine against hsv is available. cj9-gd is a completely replication-defective hsv-1 recombinant which inhibits replication of wild-type hsv-1/-2 in co-infected cells (dominant-negative effect). moreover, it expresses high levels of hsv-1 major antigen glycoprotein d (gd). immunization with cj9-gd induces strong and long-lasting humoral and th1-l ... | 2010 | 21052616 |
| the effect of emodin, an anthraquinone derivative extracted from the roots of rheum tanguticum, against herpes simplex virus in vitro and in vivo. | herpes simplex viruses (hsv-1 and -2) are important pathogens for humans and the discovery of novel anti-hsv drugs with low toxicity deserves great efforts. rhubarb is one of the oldest and best-known traditional chinese medicines. we initiated this study to test if emodin is the active ingredients from rheum tanguticum (r. tanguticum, one of the chinese rhubarb) against hsv infection and to investigate its antiviral activity on hsv infection in tissue culture cells and in a mouse model. | 2010 | 21050882 |
| synthesis and antiviral activities of synthetic glutarimide derivatives. | a series of novel glutarimide compounds were synthesized and their antiviral activities were evaluated. the compounds displaying the strongest antiviral activities included 5, 6f, 7e and 9 against coxsackievirus b3 (cox b3), 10 and 6f against influenza virus a (influenza a) and 7a against herpes simplex virus 2 (hsv-2). however, most of the synthetic glutarimides showed comparatively much weaker activity against influenza a, cox b3 and hsv-2 than the natural glutarimide compounds tested. based o ... | 2010 | 21048333 |
| seroprevalence of herpes simplex virus type-2 among patients attending the sexually transmitted infections clinic in jos, nigeria. | infection with herpes simplex virus type-2 (hsv-2) is the primary cause of genital herpes and the most common cause of genital ulcer disease (gud) worldwide. there is little information on the prevalence of hsv-2 in nigeria. | 2010 | 21045370 |
| [experience with multiplex nested pcr and fluorescent antibody tests in the diagnosis of acute central nervous system infections with herpes simplex virus type 1 and 2]. | the specific diagnosis of herpes simplex virus type 1 and 2 infections has an extreme importance in acute infections of central nervous system due to both availability of specific antiviral therapy and the possible serious consequences of the disease. aims: evaluation of the relevance and interpretation of the results of pcr and the specific antibody testing. methods: home made multiplex nested herpes simplex virus pcr and immunofluorescent igm, iga, igg antibody tests were carried out in a tota ... | 2010 | 21044940 |
| fulminant herpes simplex virus hepatic failure in pregnancy requiring liver transplantation. | herpes simplex virus hepatitis is a rare but potentially fatal condition that usually affects the immunocompromised, including pregnant women. this case report details the course of fulminant hepatic failure in a woman at 31 weeks gestation resulting in emergent delivery of the fetus and liver transplant in the mother. | 2010 | 21039387 |
| pemphigus vulgaris and herpesviruses: is there any relationship? | pemphigus is an autoimmune disorder, which results from interaction of exogenous and endogenous factors. one of these environmental factors is viral infections particularly, herpesviruses. we aimed to detect the presence of hsv 1 and 2 (herpes simplex virus) and hhv8 (human herpesvirus 8) in our patients who were suffering from pemphigus vulgaris. | 2010 | 21038546 |
| completely assembled virus particles detected by transmission electron microscopy in proximal and mid-axons of neurons infected with herpes simplex virus type 1, herpes simplex virus type 2 and pseudorabies virus. | the morphology of alphaherpesviruses during anterograde axonal transport from the neuron cell body towards the axon terminus is controversial. reports suggest that transport of herpes simplex virus type 1 (hsv-1) nucleocapsids and envelope proteins occurs in separate compartments and that complete virions form at varicosities or axon termini (subassembly transport model), while transport of a related alphaherpesvirus, pseudorabies virus (prv) occurs as enveloped capsids in vesicles (assembled tr ... | 2010 | 21036381 |
| herpetic necrotizing retinitis following flucinolone acetonide intravitreal implant. | to report a case of herpes simplex virus-induced herpetic necrotizing retinitis after placement of a flucinolone acetonide (retisert) intravitreal implant. | 2010 | 21034309 |
| a fas gene polymorphism influences herpes simplex virus type 2 infection in south african women. | herpes simplex virus type 2 (hsv-2) is a common sexually transmitted infection (sti) worldwide that causes genital infection. among several factors responsible, host genetic factors may play an important role in susceptibility to hsv-2 infection. apoptosis is a vital mechanism in eliminating virus-infected cells and controlling viral infections. apoptosis can be regulated and triggered by the interaction between fas and fas ligand (fasl). polymorphisms in genes encoding fas and fasl might result ... | 2010 | 20981796 |
| contraceptive practices, sexual and reproductive health needs of hiv-positive and negative female sex workers in goa, india. | in india, female sex workers (fsws), suffer from high hiv prevalence and abortions. contraceptive use among general population women is well understood. however, fsws contraceptives practices and reproductive health needs are under-researched. we investigated contraceptive practices among hiv-positive and negative fsws in goa, india and explored its association with socio-demographic and sex work related factors. | 2010 | 20980465 |
| targeting the hotspots: investigating spatial and demographic variations in hiv infection in small communities in south africa. | in south africa, the severity of the hiv/aids epidemic varies according to geographical location; hence, localized monitoring of the epidemic would enable more effective prevention strategies. our objectives were to assess the core areas of hiv infection in kwazulu-natal, south africa, using epidemiological data among sexually active women from localized communities. | 2010 | 20979651 |
| [genital herpes--epidemiological and clinical issue still of importance]. | genital herpes (gh) is one of the most frequent sexually transmitted diseases and the most frequent cause of genital ulcer diseases. its etiological agent is herpes simplex virus type 1 (hsv-1) or 2 (hsv-2). the role of hsv-1 as a cause of gh is increasing, especially among adolescents in developed countries. the principal route of infection with hsv is asymptomatic viral shedding. the infection is life-long, despite treatment. the data on the prevalence and incidence of gh is incomplete, mainly ... | 2010 | 20976950 |
| herpes simplex virus type 2 associated with hiv infection among new york heterosexuals living in high-risk areas. | herpes simplex virus type 2 (hsv-2) has been shown to increase the risk of sexual human immunodeficiency virus (hiv) transmission. a matched case-control design was used to examine the association between hsv-2 and hiv infection among heterosexuals in 'high-risk areas' (hras) in new york city (nyc). we identified nyc hras using hiv surveillance data on heterosexual-related adult hiv diagnoses and usa census data on household poverty. heterosexuals who were socially or geographically linked to an ... | 2010 | 20975092 |
| mouse cd8alpha+ dcs and human bdca3+ dcs are major producers of ifn-lambda in response to poly ic. | polyinosinic:polycytidylic acid (poly ic), a double-stranded rna, is an effective adjuvant in vivo. ifn-λs (also termed il-28/29) are potent immunomodulatory and antiviral cytokines. we demonstrate that poly ic injection in vivo induces large amounts of ifn-λ, which depended on hematopoietic cells and the presence of tlr3 (toll-like receptor 3), irf3 (ifn regulatory factor 3), irf7, ifn-i receptor, fms-related tyrosine kinase 3 ligand (fl), and irf8 but not on myd88 (myeloid differentiation fact ... | 2010 | 20975040 |
| herpes simplex virus type 2 meningitis and symptomatic migraine. | 2010 | 20957382 | |
| coexistent cervical spine fusion and thoracic disc herniations with acute myelitis. | thoracic disc herniations are commonly found in asymptomatic individuals, sometimes with genetic predisposition. congenital fusions of cervical vertebrae occur in klippel-feil syndrome, which may be asymptomatic or cause compressive myelitis due to cervical instability or associated herniated discs. we report the case of a 72-year-old man with monophasic acute transverse myelitis probably caused by herpes simplex virus, coexistent with fused cervical vertebrae (c4-c5) and thoracic herniated disc ... | 2010 | 20956874 |
| mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes. | herpes simplex virus-2 (hsv-2) shedding episodes in humans vary markedly in duration and virologic titer within an infected person over time, an observation that is unexplained. to evaluate whether host or virological factors more closely accounted for this variability, we combined measures of viral replication and cd8(+) lymphocyte density in genital biopsies, with a stochastic mathematical model of hsv-2 infection. model simulations reproduced quantities of virus and duration of shedding detec ... | 2010 | 20956313 |
| the environment and susceptibility to schizophrenia. | in the present article the putative role of environmental factors in schizophrenia is reviewed and synthesized. accumulating evidence from recent studies suggests that environmental exposures may play a more significant role in the etiopathogenesis of this disorder than previously thought. this expanding knowledge base is largely a consequence of refinements in the methodology of epidemiologic studies, including birth cohort investigations, and in preclinical research that has been inspired by t ... | 2010 | 20955757 |
| can we reduce the spread of hiv infection by suppressing herpes simplex virus type 2 infection? | overwhelming evidence from observational epidemiological studies indicates that herpes simplex virus type 2 (hsv-2) infection enhances the risk of acquiring hiv infection. studies of genital shedding of hiv have suggested that hsv-2 infection also increases the onward transmission of hiv-1 by hiv/hsv-2 co-infected patients. several randomized controlled trials were initiated to assess the impact of hsv-2 suppressive therapy on the acquisition of hiv infection by hsv-2 infected men and women, and ... | 2010 | 20948843 |
| immunology. painful failure of promising genital herpes vaccine. | 2010 | 20947733 | |
| a rapid and simple isothermal nucleic acid amplification test for detection of herpes simplex virus types 1 and 2. | a simple and rapid isoamp hsv assay has been developed for qualitative detection of herpes simplex virus (hsv) types 1 and 2 from genital lesions. sample preparation involved a simple dilution step and the diluted specimens were directly added to the device and amplified by isothermal helicase-dependent amplification (hda). amplification products were then detected by a dna strip embedded in a disposable cassette without any instrument. the total test turn-around time is less than 1.5h from spec ... | 2010 | 20947417 |
| case for diagnosis. | since the first reports and descriptions of aids in the early 1980s, herpetic infection has been considered as one of the most prevalent and opportunistic aids related infections in patients with retroviral diseases infection by herpes simplex type 2 (hsv-2), the etiologic agent responsible for 60% to 90% of the cases of genital herpes, is very common among patients suffering from aids. herpes simplex type 2 infection may cause severe and prolonged (over a period of time of one month) mucocutane ... | 2010 | 20944923 |
| circumcision and herpes simplex virus-2 infection among spouses. | 2010 | 20943825 | |
| associations between childhood adversity and depression, substance abuse and hiv and hsv2 incident infections in rural south african youth. | to describe prevalence of childhood experiences of adversity in rural south african youth and their associations with health outcomes. | 2010 | 20943270 |
| [herpes simplex virus type 1 and 2]. | 2010 | 20942065 | |
| no selection of nucleoside reverse transcriptase inhibitor resistance associated mutations by acyclovir suppressive therapy in herpes simplex virus-2/hiv-1 dually infected persons. | 2010 | 20940537 | |
| development of an in vitro alternative assay method for vaginal irritation. | the vaginal mucosa is commonly exposed to chemicals and therapeutic agents that may result in irritation and/or inflammation. in addition to acute effects, vaginal irritation and inflammation can make women more susceptible to infections such as hiv-1 and herpes simplex virus 2 (hsv-2). hence, the vaginal irritation potential of feminine care formulations and vaginally administered therapeutic agents is a significant public health concern. traditionally, testing of such materials has been perfor ... | 2010 | 20937349 |
| the use of ozonated water and 0.2% chlorhexidine in the treatment of periodontitis patients: a clinical and microbiologic study. | the development of periodontal disease has been thought to be associated with several restricted members of the oral anaerobic species, such as black-pigmented porphyromonas species and actinobacillus actinomycetemcomitans (aa), in the subgingival environment. apart from bacteria, certain viruses and fungi that are associated with periodontal disease are also present in the subgingival plaque . | 2010 | 20930341 |
| efficacy of cmx001 against herpes simplex virus infections in mice and correlations with drug distribution studies. | cmx001, an orally active lipid conjugate of cidofovir, is 50 times more active in vitro against herpes simplex virus (hsv) replication than acyclovir or cidofovir. these studies compared the efficacy of cmx001 to acyclovir in balb/c mice inoculated intranasally with hsv types 1 or 2. cmx001 was effective in reducing mortality using doses of 5 to 1.25 mg/kg administered orally once daily, even when treatments were delayed 48-72 h post viral inoculation. organ samples obtained from mice treated wi ... | 2010 | 20923374 |
| [use of interferon inducers for pharmacological correction of cytokine disturbances in patients with recurrent genital herpes]. | the level ofcytokines was studied in the blood of 111 women aged 18 to 56 with recurrent genital herpes caused by herpes simplex virus (hsv) type 1 or 2 (for the frequency of relapses within 6-9 year) treated with interferon inducers iodantipyrin, cycloferon and amixin in combination with basic aciclovir therapy. it is found that, in patients with clinical effect of treatment (decrease in the frequency of relapses) the level of cytokines of nonspecific immune response (alpha-interferon, beta-int ... | 2010 | 20919558 |
| treatment of herpes simplex virus infections in pediatric patients: current status and future needs. | herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) are members of the herpesviridae family and are characterized by their ability to establish latency after primary infection and subsequently reactivate. hsv infections in the neonatal and pediatric populations range from uncomplicated mucocutaneous diseases to severe, life-threatening infections involving the central nervous system (cns). the antiviral agent acyclovir has significantly improved treatment outcomes of hsv infections, including ... | 2010 | 20881952 |
| the regai dzive shiri project: results of a randomized trial of an hiv prevention intervention for youth. | hiv prevention among young people in southern africa is a public health priority. there is little rigorous evidence of the effectiveness of different intervention approaches. we describe findings of a cluster randomized trial of a community-based, multicomponent hiv, and reproductive health intervention aimed at changing social norms for adolescents in rural zimbabwe. | 2010 | 20881473 |
| time trends of syphilis and hsv-2 co-infection among men who have sex with men in the german hiv-1 seroconverter cohort from 1996-2007. | numbers of newly diagnosed hiv infections among men who have sex with men (msm) in germany increased after the year 2000. we sought to explore trends in sti co-infections around the time of hiv seroconversion in patients from the german hiv-1 seroconverter cohort from 1996-2007. | 2010 | 20876750 |
| [effects of silver and silicon dioxide nanopowders on the development of herpesvirus infection in vitro]. | estimation of the potential ability of nanoparticles (np) to affect human health has generated a need for developing rapid, sensitive, and efficient laboratory tests of the toxicity of nanomaterials. the purpose of the investigation was to study the cytotoxic effect of np of silver (ag) and silicon dioxide (sio2). the transplantable vero cells treated with np at different concentrations were used as target cells. some experiments examined the combined effects of nanopowders and herpes simplex vi ... | 2010 | 20873393 |