Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| a retrospective study into the prevalence of herpes simplex virus 1&2 in female patients tested for chlamydia trachomatis and/or neisseria gonorrhoeae using vaginal swabs. | the purpose of this study was to investigate the prevalence of herpes simplex virus (hsv) 1&2 in women screened for chlamydia trachomatis and/or neisseria gonorrhoeae (ct/gc) infections. a total of 800 vaginal swabs were tested in a dual centre investigation, to evaluate the prevalence of hsv-1&2 in this population. the average age of the population was 29.8 ± 9.2 years, ranging between 14 and 66 years with a median of 28 years. the highest prevalence of hsv-1 or hsv-2 was observed in the younge ... | 2013 | 23320468 |
| mucosal herpes immunity and immunopathology to ocular and genital herpes simplex virus infections. | herpes simplex viruses type 1 and type 2 (hsv-1 and hsv-2) are amongst the most common human infectious viral pathogens capable of causing serious clinical diseases at every stage of life, from fatal disseminated disease in newborns to cold sores genital ulcerations and blinding eye disease. primary mucocutaneous infection with hsv-1 & hsv-2 is followed by a lifelong viral latency in the sensory ganglia. in the majority of cases, herpes infections are clinically asymptomatic. however, in symptom ... | 2012 | 23320014 |
| herpes simplex virus type 2 infection among females in enugu, enugu state. | herpes simplex virus type 2 infecion is life long with manifestation in a small proportion of those infected. it has presented public health concern because of its progressively increasing prevalence which some authorities say is of epidemic proportion in developing countries. herpes simplex virus type 2 has recently been found to have synergistic effect with human immunodeficiency virus (hiv) and co-infection of the two presents more severe burden to the immunity of the victim. this leads to mu ... | 2012 | 23304946 |
| lat region factors mediating differential neuronal tropism of hsv-1 and hsv-2 do not act in trans. | after hsv infection, some trigeminal ganglion neurons support productive cycle gene expression, while in other neurons the virus establishes a latent infection. we previously demonstrated that hsv-1 and hsv-2 preferentially establish latent infection in a5+ and kh10+ sensory neurons, respectively, and that exchanging the latency-associated transcript (lat) between hsv-1 and hsv-2 also exchanges the neuronal preference. since many viral genes besides the lat are functionally interchangeable betwe ... | 2012 | 23300908 |
| polyethylenimine combined with liposomes and with decreased numbers of primary amine residues strongly enhanced therapeutic antiviral efficiency against herpes simplex virus type 2 in a mouse model. | the development of antiviral agents that have novel mechanisms of action is urgently required in the topical therapy of herpes simplex virus type 2 (hsv-2) infections. we reported previously that topical application of branched 3610-da polyethylenimine (pei) exhibited preventative antiviral activity. in this study, to develop therapeutic anti-hsv-2 agents, the most potent pei combined with ~200 nm-sized liposomes with or without oleic acid (liposomes/pei) was selected in vitro and further evalua ... | 2013 | 23298614 |
| [detection of human cytomegalovirus and herpes simplex virus type 2 in cervical sample]. | to detect the presence of human cytomegalovirus (hcmv) and herpes simplex virus type 2 (hsv-2) dna in cervical samples from women assisted in a primary health care clinic in the city of coari, amazonas, brazil. | 2012 | 23288260 |
| prevalence of serum antibodies to torch infection in and around varanasi, northern india. | the acute infections which are caused by toxoplasma gondii, rubella virus, cytomegalovirus (cmv) and the herpes simplex virus (hsv-2) during pregnancy are often associated with adverse foetal outcomes and reproductive failures. in the indian context, the exact seroprevalence of these infections is not known due to unavailability of baseline data. | 2012 | 23285435 |
| alphaherpesvirinae and gammaherpesvirinae glycoprotein l and cmv ul130 originate from chemokines. | herpesviridae is a large family of dna viruses divided into three subfamilies: alpha-, beta- and gammaherpesvirinae. the process of herpesvirus transmission is mediated by a range of proteins, one of which is glycoprotein l (gl). based on our analysis of the solved structures of hsv2 and ebv gh/gl complexes, we propose that alphaherpesvirinae and gammaherpesvirinae glycoprotein l and betaherpesvirinae ul130 originate from chemokines. herpes simplex virus type 2 gl and human cytomegalovirus homol ... | 2013 | 23279912 |
| pharmacokinetics and pharmacodynamics of asp2151, a helicase-primase inhibitor, in a murine model of herpes simplex virus infection. | asp2151 (amenamevir) is a helicase-primase inhibitor against herpes simplex virus 1 (hsv-1), hsv-2, and varicella zoster virus. here, to determine and analyze the correlation between the pharmacodynamic (pd) and pharmacokinetic (pk) parameters of asp2151, we examined the pd profile of asp2151 using in vitro plaque reduction assay and a murine model of hsv-1 infection. asp2151 inhibited the in vitro replication of hsv-1 with a mean 50% effective concentration (ec(50)) of 14 ng/ml. in the cutaneou ... | 2012 | 23274658 |
| enhancement of antiviral activity of human alpha-defensin 5 against herpes simplex virus 2 by arginine mutagenesis at adaptive evolution sites. | herpes simplex virus 2 (hsv-2) infection is still one of the common causes of sexually transmitted diseases worldwide. the prevalence of hsv strains resistant to traditional nucleoside antiviral agents has led to the development of novel antiviral drugs. human alpha-defensin 5 (hd5), a kind of endogenous antimicrobial peptide expressed in the epithelia of the small intestine and urogenital tract, displays natural antiviral activity. based on arginine-rich features and adaptive evolution characte ... | 2012 | 23269800 |
| synergistic activity of amenamevir (asp2151) with nucleoside analogs against herpes simplex virus types 1 and 2 and varicella-zoster virus. | asp2151 (amenamevir) is a helicase-primase complex inhibitor with antiviral activity against herpes simplex virus hsv-1, hsv-2, and varicella-zoster virus (vzv). to assess combination therapy of asp2151 with existing antiherpes agents against hsv-1, hsv-2, and vzv, we conducted in vitro and in vivo studies of two-drug combinations. the combination activity effect of asp2151 with nucleoside analogs acyclovir (acv), penciclovir (pcv), or vidarabine (vdb) was tested via plaque-reduction assay and m ... | 2013 | 23261844 |
| serological investigation of the role of selected sexually transmitted infections in the aetiology of ectopic pregnancy. | to investigate the association between selected sexually transmitted infections (stis) and the later occurrence of ectopic pregnancy. | 2013 | 23256948 |
| the challenge of developing a herpes simplex virus 2 vaccine. | hsv infections are prevalent worldwide. a vaccine to prevent genital herpes would have a significant impact on this disease. several vaccines have shown promise in animal models; however, so far these have not been successful in human clinical studies. prophylactic hsv vaccines to prevent hsv infection or disease have focused primarily on eliciting antibody responses. potent antibody responses are needed to result in sufficiently high levels of virus-specific antibody in the genital tract. thera ... | 2012 | 23252387 |
| pityriasis lichenoides chronica associated with herpes simplex virus type 2. | introduction. pityriasis lichenoides is a rare, acquired spectrum of skin conditions of an unknown etiology. case report. a 28-year-old man presented with recurrent outbreaks of herpes simplex virus associated with the onset of red-to-brown maculopapules located predominantly in trunk in each recurrence. positive serologies to herpes simplex virus type 2 were detected. histopathological examination of one of the lesions was consistent with a diagnosis of pityriasis lichenoides chronica. discussi ... | 2012 | 23243523 |
| viral infections of the central nervous system in spain: a prospective study. | the aim of the study was to determine the incidence of viruses causing aseptic meningitis, meningoencephalitis, and encephalitis in spain. this was a prospective study, in collaboration with 17 spanish hospitals, including 581 cases (csf from all and sera from 280): meningitis (340), meningoencephalitis (91), encephalitis (76), febrile syndrome (7), other neurological disorders (32), and 35 cases without clinical information. csf were assayed by pcr for enterovirus (ev), herpesvirus (herpes simp ... | 2013 | 23239485 |
| [the genotyping and molecular evolution of varicella-zoster virus]. | varicella-zoster virus (vzv, human herpesvirus 3) is a member of the family herpesviridae, and is classified as alpha-subfamily along with hsv-1 and hsv-2. vzv is the causative agent of chicken pox (varicella) mostly in children, after which it establishes latency in the sensory ganglia with the potential to reactivate at a later time to cause shingles (zoster). increasing molecular epidemiological studies in recent years have been performed to monitor the mutations in vzv genome, discriminate v ... | 2012 | 23233938 |
| topical smip-7.7, a toll-like receptor 7 agonist, protects against genital herpes simplex virus type-2 disease in the guinea pig model of genital herpes. | development of more effective therapies for genital herpes simplex virus type-2 (hsv-2) infections remains a priority. the toll-like receptors (tlr) are attractive targets for the immunomodulation of primary and recurrent genital herpes infection. the guinea pig model of genital hsv-2 disease was therefore used to evaluate the efficacy of a new tlr-7 agonist, smip-7.7. | 2014 | 23232327 |
| herpes simplex virus type 2 risks in female sex workers in the china-vietnam border county of hekou. | to survey the prevalence and risk factors of hsv-2 among chinese and vietnamese female sex workers (fsw) in the border county of hekou, yunnan province, china. | 2012 | 23228841 |
| response to 'herpes simplex virus type-2 (hsv-2) assay specificity and male circumcision to reduce hsv-2 acquisition. | 2013 | 23221431 | |
| herpes simplex virus type-2 assay specificity and male circumcision to reduce herpes simplex virus type-2 acquisition. | 2013 | 23221430 | |
| anti-herpes virus activities of achyranthes aspera: an indian ethnomedicine, and its triterpene acid. | the aim of this study was to evaluate the antiviral potential of methanolic extract (me) of achyranthes aspera, an indian folk medicine and one of its pure compound oleanolic acid (oa) against herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2). the me possessed weak anti-herpes virus activity (ec50 64.4μg/ml for hsv-1 and 72.8μg/ml for hsv-2). while oa exhibited potent antiherpesvirus activity against both hsv-1 (ec50 6.8μg/ml) and hsv-2 (ec50 7.8μg/ml). the time response study revealed that ... | 2013 | 23218996 |
| sp-303, an antiviral oligomeric proanthocyanidin from the latex of croton lechleri (sangre de drago). | sp-303, a large proanthocyanidin oligomer isolated from the latex of the plant species croton lechleri (eupborbiaceae) has demonstrated broad activity against a variety of dna and rna viruses. in cell culture, sp-303 exhibits potent activity against isolates and laboratory strains of respiratory syncytial virus (rsv), influenza a virus (flu-a) and parainfluenza virus (piv). parallel assays of sp-303 and ribavirin showed comparable activity against these viruses. sp-303 also exhibits significant ... | 1994 | 23195881 |
| herpesvirus entry mediator is a serotype specific determinant of pathogenesis in ocular herpes. | infection with herpes simplex virus type 1 (hsv-1) and hsv-2 is initiated by viral glycoprotein d (gd) binding to a receptor on the host cell. two receptors, herpesvirus entry mediator (hvem) and nectin-1, mediate entry in murine models of hsv-1 and hsv-2. hvem is dispensable for hsv-2 infection of the vagina and brain, but is required for wt pathogenesis of hsv-1 infection of the cornea. by challenging wt and hvem ko mice with multiple strains of hsv-1 and hsv-2, we demonstrate that without hve ... | 2012 | 23184983 |
| the mirnas of herpes simplex virus (hsv). | herpes simplex virus (hsv) is a group of common human pathogens with two serotypes hsv-1 and hsv-2. the prevalence of hsv is worldwide. it primarily infects humans through epithelial cells, when it introduces a latent infection into the nervous system. during viral latency, only a region known as the latency-associated transcript (lat) is expressed. the discovery of hsv mirnas helps to draw a larger picture of the infection and pathogenesis of the virus. this review summarizes mirnas found in hs ... | 2012 | 23180288 |
| [incidence of human herpes virus 1-4 type in saliva of 245 human immunodeficiency virus-infected patients]. | to determine the incidence of human herpes virus (hhv) 1-4 type including herpes simplex virus type-1 (hsv-1), herpes simplex virus type-2 (hsv-2), varicella-zoster virus (vzv), epstein-barr virus(ebv) in the saliva of human immunodeficiency virus (hiv) -infected patients. | 2012 | 23173318 |
| hiv incidence among men who have sex with men in beijing: a prospective cohort study. | (1) to assess the hiv incidence rate among men who have sex with men (msm) in a large cohort study in beijing, china and (2) to identify sociodemographic and behavioural risk factors of hiv seroconversion among msm in beijing, china. | 2012 | 23166133 |
| in vitro antiviral activity of dermaseptin s(4) and derivatives from amphibian skin against herpes simplex virus type 2. | herpes simplex virus (hsv) infections have become a public health problem worldwide. the emergence of acyclovir-resistant viral strains and the failure of vaccination to prevent herpetic infections have prompted the search for new antiviral drugs. accordingly, the present study was undertaken to synthesize chemically and evaluate dermaseptin s(4) (s(4)), an anti-microbial peptide derived from amphibian skin, and its derivatives in terms of anti-herpetic activity. the effects of biochemical modif ... | 2013 | 23161023 |
| association between herpes simplex virus type 2 and hiv-1 in a population of married couples from dakar, senegal. | numerous studies suggest that herpes simplex virus type 2 (hsv-2) increases the risk of hiv-1 infection but recent clinical trials of hsv-2 suppressive therapy failed to show an effect. we assessed the putative association between hsv-2 and hiv-1 in a population of hiv-concordant-negative, hiv-1-discordant and hiv-1-concordant-positive married couples from dakar, senegal. in agreement with previous studies, we observed a strong overall association between hsv-2 and hiv-1 (odds ratio 4.61; p < 0. ... | 2012 | 23155102 |
| herpes simplex virus type 2 infection as a biomarker for sexual debut among young people in sub-saharan africa: a literature review. | biological markers are needed in order to provide objective measures to validate self-reported sexual behaviour and interpret prevention trial data. in this review, we evaluated herpes simplex type 2 virus (hsv-2), one of the most prevalent sexually transmitted infections in sub-saharan africa as a biological marker of sexual debut. based on our findings, we do not recommend using hsv-2 as a biomarker for sexual debut due to its low transmission probabilities and the fact that hsv-2 prevalence i ... | 2012 | 23155093 |
| serologic screening for herpes simplex virus type 2 in persons with human immunodeficiency virus. | screening for subclinical herpes simplex virus type 2 (hsv-2) may be a useful adjunct in human immunodeficiency virus (hiv) care. however, hsv-2 serological tests have been suggested to perform less well in hiv-infected populations. in this study, herpeselect hsv-2 elisa was compared with the sure-vue rapid hsv-2 test for hsv-2 screening of sera from 310 hiv-infected persons receiving care at an hiv-dedicated clinic in the southeastern united states. in the study, assay agreement and whether the ... | 2013 | 23154653 |
| individual and network factors associated with prevalent hepatitis c infection among rural appalachian injection drug users. | we determined the factors associated with hepatitis c (hcv) infection among rural appalachian drug users. | 2013 | 23153148 |
| herpes simplex virus 2 (hsv-2) prevents dendritic cell maturation, induces apoptosis, and triggers release of proinflammatory cytokines: potential links to hsv-hiv synergy. | herpes simplex virus 2 (hsv-2) may cause frequent recurrences, highlighting its ability to evade host defense. this study tested the hypothesis that hsv-2 interferes with dendritic cell (dc) function as an escape mechanism, which may contribute to enhanced hiv replication in coinfected populations. immature monocyte-derived human dcs were exposed to live or uv-inactivated hsv-2 or lipopolysaccharide. little or no increase in the maturation marker cd83 was observed in response to hsv-2 and hsv-2 ... | 2013 | 23152529 |
| seroepidemiology of herpes simplex virus type 1 and 2 in northern iran. | herpes simplex virus (hsv) type 1 and 2 are common infectious agents worldwide. data on prevalence of hsv-1 and hsv-2 infection are limited in asia, especially in iran. the aim of this study was to determine the seroprevalence of hsv type 1 and 2 based on age, gender, marital status, education, living area, job, symptoms and history of disease variables. | 2012 | 23113228 |
| tin oxide nanowires suppress herpes simplex virus-1 entry and cell-to-cell membrane fusion. | the advent of nanotechnology has ushered in the use of modified nanoparticles as potential antiviral agents against diseases such as herpes simplex virus 1 and 2 (hsv-1) (hsv-2), human immunodeficiency virus (hiv), monkeypox virus, and hepatitis b virus. here we describe the application of tin oxide (sno(2)) nanowires as an effective treatment against hsv-1 infection. sno(2) nanowires work as a carrier of negatively charged structures that compete with hsv-1 attachment to cell bound heparan sulf ... | 2012 | 23110193 |
| associations between drug use and risk behaviours for hiv and sexually transmitted infections among female sex workers in yunnan, china. | this is a cross-sectional study of 399 subjects conducted to explore the association between drug use and risk behaviour for hiv and sexually transmitted infections (stis) among female sex workers (fsws), and also to study the prevalence of hiv/stis among drug-using fsws (dufsws) and non-dufsws in yunnan province of china. demographic information, mobility, sexual and drug-using behaviours were collected and subjects were tested for hiv/stis. mean age was 27 years (sd = ±7.8) and 94 (23.6%) test ... | 2012 | 23104743 |
| pathogenesis of neonatal herpes simplex 2 disease in a mouse model is dependent on entry receptor expression and route of inoculation. | herpes simplex virus (hsv) pathogenesis in mice differs based on availability of the principal entry receptors herpesvirus entry mediator (hvem) and nectin-1 in a manner dependent upon route of inoculation. after intravaginal or intracranial inoculation of adult mice, nectin-1 is a major mediator of neurologic disease, while the absence of either receptor attenuates disease after ocular infection. we tested the importance of receptor availability and route of infection on disease in mouse models ... | 2013 | 23097453 |
| epidemiology, clinical presentation, and antibody response to primary infection with herpes simplex virus type 1 and type 2 in young women. | herpes simplex virus infections type 1 (hsv-1) and type 2 (hsv-2) are common, but the epidemiology of hsv disease is changing. | 2013 | 23087395 |
| incidence of alpha-herpes virus induced ocular disease in suriname. | herpes simplex virus (hsv) infection of the corneal stroma is the most prominent cause of scar formation impairing visual acuity and hsv keratitis is the leading cause of corneal opacity throughout the world. suriname lacked test systems for microbial causes of ocular disease, therefore a polymerase chain reaction-based herpes virus assay was introduced, enabling prompt recognition, and timely treatment, preventing progressive eye damage. the incidence and epidemiology of herpes simplex virus ty ... | 2012 | 23080500 |
| relationship between cervical disease and infection with human papillomavirus types 16 and 18, and herpes simplex virus 1 and 2. | persistent infection with high-risk hpv, particularly type hpv 16 and 18, is necessary in the development of cervical cancer, but apart from hpv infection, other causative factors of most cervical cancers remain unknown. the aim of this study was to determine the prevalence of hpv 16 and hpv 18 and hsv 1 and hsv 2 in cervical samples, and to assess the role of hsvs in cervical carcinogenesis. two hundred thirty-three healthy controls and 567 cases (333 of cervicitis, 210 of cervical intraepithel ... | 2012 | 23080497 |
| a vaccine strategy that protects against genital herpes by establishing local memory t cells. | most successful existing vaccines rely on neutralizing antibodies, which may not require specific anatomical localization of b cells. however, efficacious vaccines that rely on t cells for protection have been difficult to develop, as robust systemic memory t-cell responses do not necessarily correlate with host protection. in peripheral sites, tissue-resident memory t cells provide superior protection compared to circulating memory t cells. here we describe a simple and non-inflammatory vaccine ... | 2012 | 23075848 |
| midtrimester fetal herpes simplex-2 diagnosis by serology, culture and quantitative polymerase chain reaction. | the acquisition of herpes simplex virus (hsv) in utero comprises a minority of neonatal herpes infections. prenatal diagnosis is rare. we describe a midtrimester diagnosis of fetal hsv-2 infection. ultrasound at 20 weeks for elevated maternal serum α-fetoprotein (msafp) showed lagging fetal growth, echogenic bowel, echogenic myocardium, and liver with a mottled pattern of echogenicity. amniocentesis demonstrated normal karyotype, elevated afp and positive acetylcholinesterase. culture isolated h ... | 2013 | 23075531 |
| immunogenicity and efficacy of intramuscular replication-defective and subunit vaccines against herpes simplex virus type 2 in the mouse genital model. | herpes simplex virus type 2 (hsv-2) is a sexually transmitted virus that is highly prevalent worldwide, causing a range of symptoms that result in significant healthcare costs and human suffering. acam529 is a replication-defective vaccine candidate prepared by growing the previously described dl5-29 on a cell line appropriate for gmp manufacturing. this vaccine, when administered subcutaneously, was previously shown to protect mice from a lethal vaginal hsv-2 challenge and to afford better prot ... | 2012 | 23071620 |
| epidemiological impact of a genital herpes type 2 vaccine for young females. | genital herpes, which is caused by herpes simplex virus-1 or -2 (hsv-1, -2, predominantly hsv-2) is a sexually transmitted infection (sti) that causes a chronic latent infection with outbreak episodes linked to transmission. antiviral therapies are effective in reducing viral shedding during these episodes, but are ineffective as a whole since many outbreaks are asymptomatic or have mild symptoms. thus, the development of a vaccine for genital herpes is needed to control this disease. the questi ... | 2012 | 23071536 |
| prevalence and associations of genital ulcer and urethral pathogens in men presenting with genital ulcer syndrome to primary health care clinics in south africa. | this study aimed to determine the prevalence of genital ulcer and urethral pathogens, as well as their association with clinical features, in men with genital ulcer disease (gud) enrolled in a clinical trial. | 2012 | 23064538 |
| predictors of undiagnosed herpes simplex virus type 2 seropositivity among persons attending an hiv care clinic. | we evaluated herpes simplex virus type 2 (hsv-2) sero- positivity in an hiv clinic- based population with cd4 lymphocytes counts ≥250 cells/μl and no previous knowledge of hsv-2 infection by history of serology. we demonstrate that although the seroprevalence of hsv-2 is higher in this hiv-infected population, predictors of hsv-2 seropositivity are similar to those in the general population. | 2012 | 23064534 |
| partner characteristics predicting hiv-1 set point in sexually acquired hiv-1 among african seroconverters. | plasma hiv-1 rna set point is an important predictor of hiv-1 disease progression. we hypothesized that inoculum size and hiv-1 exposure prior to hiv-1 transmission may modulate set point. we evaluated predictors of set point among 141 african hiv-1 seroconverters and their hiv-1-infected study partners. we compared characteristics of seroconverters and their hiv-1-infected partners and hiv-1 set point. data were from a clinical trial of genital hsv-2 suppression with acyclovir to reduce hiv-1 t ... | 2013 | 23061422 |
| h11/hspb8 and its herpes simplex virus type 2 homologue icp10pk share functions that regulate cell life/death decisions and human disease. | small heat shock proteins (shsp) also known as hspb are a large family of widely expressed proteins that contain a 90 residues domain known as α-crystallin. here, we focus on the family member h11/hspb8 and its herpes simplex virus type 2 (hsv-2) homologue icp10pk, and discuss the possible impact of this relationship on human disease. h11/hspb8 and icp10pk are atypical protein kinases. they share multi-functional activity that encompasses signaling, unfolded protein response (upr) and the regula ... | 2012 | 23056924 |
| serum hsv-1 and 2 igm in sexually transmitted diseases - more for screening less for diagnosis: an evaluation of clinical manifestation. | herpes simplex virus type 2 (hsv-2) is the cause of most genital herpes. now, hsv-1 has become an important cause and represents even about 30% of genital herpes in some countries. so, study related to genital herpes should consider both hsv-1 and hsv-2. | 2012 | 23055654 |
| herpes simplex virus type 2 mediated acute retinal necrosis in a pediatric population: case series and review. | we report 15 eyes with herpes simples virus type 2 (hsv-2) mediated acute retinal necrosis (arn) in order to better characterize pathogenesis, clinical course, diagnosis, and outcomes of the disease. | 2013 | 23052715 |
| prophylactic, therapeutic and neutralizing effects of zinc oxide tetrapod structures against herpes simplex virus type-2 infection. | the attachment of herpes simplex virus type-2 (hsv-2) to a target cell requires ionic interactions between negatively charged cell surface co-receptor heparan sulfate (hs) and positively charged residues on viral envelop glycoproteins, gb and gc. effective blocking of this first step of hsv-2 pathogenesis demonstrates significant prophylactic effects against the viral disease; any in vitro therapeutic effects of blocking this interaction, however, are not clear. here, we provide new evidence tha ... | 2012 | 23047013 |
| arginine inactivates human herpesvirus 2 and inhibits genital herpesvirus infection. | arginine, among the amino acids, has demonstrated unique properties, including suppression of protein-protein interactions and virus inactivation. we investigated the effects of arginine on the infectivity of human herpesvirus 2 (hhv-2) and the potential application of arginine as a chemotherapeutic agent against genital herpes. arginine directly inactivated hhv-2 and characterization of the inactivation demonstrated that 1 m arginine at ph 4.3 inactivated the virus more efficiently compared to ... | 2012 | 23042569 |
| impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity. | the acyclic analogue of guanosine acyclovir (acv) constitutes the first-line drug for the treatment of herpes simplex virus (hsv) infections. acv activation requires primophosphorylation by virus-encoded hsv thymidine kinase (tk). in 95% of cases, hsv resistance to acv is associated with mutations located in tk. the aim of this work was to address the question of the potential involvement of novel hsv-1 and hsv-2 tk mutations in reduced susceptibility to acv using a novel nonradioactive method, ... | 2012 | 23041200 |
| dynamics of the hiv epidemic in southern china: sexual and drug-using behaviours among female sex workers and male clients in yunnan. | to examine the hiv/sexually transmitted infection (sti)-related risk behaviours among community-based female sex workers (fsws) and their clients in yunnan province, china, we performed a cross-sectional study of 705 fsws and 100 male clients. we found that hiv seroprevalence among fsws was 13.0% and the most prevalent sti was herpes simplex virus type 2 (hsv-2) (71.1%), followed by chlamydia trachomatis (18.1%) and syphilis (8.8%). the 20% of fsws who reported injection drug use also reported n ... | 2012 | 23033525 |
| herpes simplex virus and hiv: genital infection synergy and novel approaches to dual prevention. | sexual transmission of hiv-1, in the absence of co-factors, is poorly efficient. data support that herpes simplex virus type-2 (hsv-2) may increase a woman's susceptibility to hiv-1. potential mechanisms by which hsv-2 serves as an hiv-1 enhancing co-factor include (1) initiation of a clinical or subclinical mucosal inflammatory response, (2) alteration of innate mucosal immunity and (3) weakening or breaching the protective genital epithelia. no clinical trial has examined prevention of primary ... | 2012 | 23033511 |
| estimation of population-size changes and hiv prevalence among female sex workers from 2006 to 2009 in kaiyuan, yunnan, china. | this study is to estimate the population size and prevalence of hiv and herpes simplex virus type 2 (hsv-2) infections among female sex workers (fsws) in kaiyuan, yunnan province, china. | 2012 | 23026531 |
| absence of viruses in amniotic fluid of women with pprom: a case series. | preterm premature rupture of membranes (pprom) and preterm birth are strongly linked to intrauterine inflammation. bacterial infection is often not identified as the cause. the objective was to examine the amniotic fluid of women with pprom for viral genomic content, and to correlate with the presence of bacterial infection and markers of intrauterine inflammation. a case series of 13 women with pprom is presented. amniocentesis was performed in each of these women. dna/rna isolated from amnioti ... | 2012 | 23021256 |
| targeting the genital tract mucosa with a lipopeptide/recombinant adenovirus prime/boost vaccine induces potent and long-lasting cd8+ t cell immunity against herpes: importance of myd88. | targeting of the mucosal immune system of the genital tract with subunit vaccines has failed to induce potent and durable local cd8(+) t cell immunity, which is crucial for protection against many sexually transmitted viral pathogens, including hsv type 2 (hsv-2), which causes genital herpes. in this study, we aimed to investigate the potential of a novel lipopeptide/adenovirus type 5 (lipo/radv5) prime/boost mucosal vaccine for induction of cd8(+) t cell immunity to protect the female genital t ... | 2012 | 23018456 |
| adjunctive hpv in-situ hybridization (ish) assay as an aid in the diagnosis of cervical intraepithelial neoplasia in cervical tissue specimens: an analytical and functional characterization. | the purpose of this study was to develop and analytically and functionally validate a new human papillomavirus (hpv) in-situ hybridization (ish) assay and to determine whether the use of this assay combined with hemotoxylin and eosin (h&e) staining could potentially improve the diagnostic accuracy of interpreting cervical intraepithelial neoplasia (cin) in human cervical tissue specimens. an automated hpv ish assay was developed using probes that targeted the broad spectrum of hpv genotypes most ... | 2012 | 23018222 |
| prevalence of herpes simplex virus types 1 and 2 and associated sociodemographic variables in pregnant women attending king fahd hospital of the university. | the risk factors associated with herpes simplex virus (hsv) seropositivity in pregnant women in saudi arabia are not known. this study was aimed at identifying the sociodemographic variables associated with seroprevalence of hsv-1 and hsv-2 in pregnant women in a saudi hospital. | 2007 | 23012136 |
| [epidemiology and risk factors of the cervical squamous cell carcinoma]. | neoplasm of the cervix, especially squamous cell cancer, is one of the most common malignancy of female genital organs. it etiology is complex; however, human papilloma virus (mostly hpv type 18, 16 and 45) infection seems to be the most important one. other risk factors include: early sexual initiation, multiple pregnancies and labors, concomitant infections (chlamydia trachomatis, neisseria gonorrhea, hsv2 - herpes simplex virus) of the genital tract, aids, immunosuppressive therapy, smoking a ... | 2012 | 23009008 |
| hiv and associated risk factors among male clients of female sex workers in a chinese border region. | male clients of female sex workers (fsws) serve as a potential bridge of human immunodeficiency virus (hiv) to the general population. little is known about the characteristics and risk factors for hiv infection among male clients patronizing fsws in hekou county, yunnan province in southern china bordering with vietnam. | 2012 | 23007705 |
| herpes genitalis without frontiers: from clinical aspects to viral identification. | genital herpes simplex virus infection is a recurrent, lifelong disease with no cure. the strongest predictor for infection is a person's number of lifetime sex partners. hsv-2 is the commonest responsible, although infections caused by hsv-1 are rapidly increasing, particularly in adolescents, women and men who have sex with men. the natural history includes first-episode of mucocutaneous infection, establishment of latency in the dorsal root ganglion, and subsequent reactivation. most infectio ... | 2012 | 23007253 |
| looking for an asymptomatic infection: usefulness of screening for chlamydia trachomatis and genital herpes. | chlamydia trachomatis (ct) and herpes simplex virus type 2 (hsv-2) genital infections are among the more frequent sexually transmissible infections with different prevalence by age, populations and geographical areas. both are widespread, have an asymptomatic latent stage detectable only by laboratory and can have serious consequences such as tubal infertility and neonatal herpes. the direct isolation of ct in cervical or urethral discharge through nucleic acid amplification test (naats) allows ... | 2012 | 23007249 |
| prevalence of hiv and other sexually transmitted infections and factors associated with syphilis among female sex workers in panama. | biological and behavioural surveillance of hiv and sexually transmitted infections (stis) among populations at highest risk have been used to monitor trends in prevalence and in risk behaviours. sex work in panama is regulated through registration with the social hygiene programme, ministry of health. we estimated prevalence of hiv and stis, and factors associated with active syphilis among female sex workers (fsws). | 2012 | 23002191 |
| etiologic pattern of genital ulcers in lusaka, zambia: has chancroid been eliminated? | genital ulcers are a public health problem in developing countries. the world health organization recommends the use of syndromic guidelines for sexually transmitted infection treatment in resource-constrained countries. monitoring local etiologies provides information that may aid policy for sexually transmitted infection treatment. we investigated the etiology of genital ulcer disease among outpatients in lusaka, zambia. | 2012 | 23001266 |
| [effect and mechanism of saururus chinensis against herpes dimplex virus]. | to seek effective drugs inhibiting herpes simplex virus (hsv-2) with the signal pathway required by virus replication as the target spot. | 2012 | 22993999 |
| a herpes simplex virus 2 glycoprotein d mutant generated by bacterial artificial chromosome mutagenesis is severely impaired for infecting neuronal cells and infects only vero cells expressing exogenous hvem. | we constructed a herpes simplex virus 2 (hsv-2) bacterial artificial chromosome (bac) clone, bhsv2-bac38, which contains full-length hsv-2 inserted into a bac vector. unlike previously reported hsv-2 bac clones, the virus genome inserted into this bac clone has no known gene disruptions. virus derived from the bac clone had a wild-type phenotype for growth in vitro and for acute infection, latency, and reactivation in mice. hvem, expressed on epithelial cells and lymphocytes, and nectin-1, expre ... | 2012 | 22993162 |
| male circumcision programmes in kenya: lessons from the kenya aids indicator survey 2007. | to provide guidance for male circumcision programmes in kenya by estimating the population of uncircumcised men and investigating the association between circumcision and infection with the human immunodeficiency virus (hiv), with particular reference to uncircumcised, hiv-uninfected men. | 2012 | 22984308 |
| persistent infection with neurotropic herpes viruses and cognitive impairment. | herpes virus infections can cause cognitive impairment during and after acute encephalitis. although chronic, latent/persistent infection is considered to be relatively benign, some studies have documented cognitive impairment in exposed persons that is untraceable to encephalitis. these studies were conducted among schizophrenia (sz) patients or older community dwellers, among whom it is difficult to control for the effects of co-morbid illness and medications. to determine whether the associat ... | 2013 | 22975221 |
| hiv and sti prevalence and determinants among male migrant workers in india. | our objective was to estimate for the first time the prevalence and determinants of human immunodeficiency virus type 1 (hiv-1) and sexually transmitted infections (stis) among male migrants in india. | 2012 | 22952708 |
| inactivated hsv-2 in mpl/alum adjuvant provides nearly complete protection against genital infection and shedding following long term challenge and rechallenge. | herpes simplex virus type 2 (hsv-2) infection can result in life-long recurrent genital disease, asymptomatic virus shedding, and transmission. no vaccine to date has shown significant protection clinically. here, we used a mouse model of genital hsv-2 infection to test the efficacy of a vaccine consisting of whole, formalin-inactivated hsv-2 (fi-hsv2) formulated with monophosphoryl lipid a (mpl) and alum adjuvants. vaccine components were administered alone or as a prime-boost immunization toge ... | 2012 | 22947141 |
| [the sexual behavior characteristics and std infection status of women who have sex with women in beijing]. | to study sexual behavioral characteristics, infection status of hiv and sexually transmitted infections (stds) among women who have sex with women (wsw) in beijing. | 2012 | 22943919 |
| poly (4-styrenesulfonic acid-co-maleic acid) is an entry inhibitor against both hiv-1 and hsv infections - potential as a dual functional microbicide. | genital herpes is one of the most prevalent sexually transmitted diseases (std) caused by herpes simplex viruses type 1 and 2 (hsv-1 and -2). hsv is considered as a major risk factor in human immunodeficiency virus type-1 (hiv-1) infection and rapid progression to acquired immunodeficiency syndrome (aids). here, we reported the finding of a polymer of styrenesulfonic acid and maleic acid (psm) which exhibited antiviral activity with low cytotoxicity. psm exhibited in vitro inhibitory activity ag ... | 2012 | 22940611 |
| a systematic review and meta-analysis of risk factors for sexual transmission of hiv in india. | approximately 2.4 million people are living with hiv in india. this large disease burden, and potential for epidemic spread in some areas, demands a full understanding of transmission in that country. we wished to quantify the effects of key sexual risk factors for hiv infection for each gender and among high- and low-hiv risk populations in india. | 2012 | 22937158 |
| hiv-1 and herpes simplex virus type-2 genital shedding among co-infected women using self-collected swabs in chiang rai, thailand. | we analysed 528 genital self-collected swabs (scs) from 67 hiv-1 and herpes simplex virus type-2 (hsv-2) co-infected women collected during the placebo month of a randomized crossover clinical trial of suppressive acyclovir in chiang rai, thailand. in this first longitudinal study of hiv-1 and hsv-2 co-infected women using genital scs specimens, we found frequent mucosal hiv-1 shedding. overall, 372 (70%) swabs had detectable hiv-1 rna with median hiv-1 viral load of 2.61 log(10) copies/swab. we ... | 2012 | 22930292 |
| sexually transmitted infections and sexual behaviour among youth clients of hotel-based female sex workers in dhaka, bangladesh. | a cross-sectional study was conducted among youth clients of hotel-based female sex workers (ychbfsws) in nine randomly selected hotels in bangladesh to examine sexual-risk behaviour, condom use and determinants of condom use in last sex, knowledge of hiv, sexually transmitted infection (sti) prevalence and sti care-seeking behaviour. a prestructured questionnaire was used to collect sociodemographic, behavioural, clinical information; urine specimens (before sex) and blood were collected for di ... | 2012 | 22930291 |
| potential role of tenofovir vaginal gel for reduction of risk of herpes simplex virus in females. | a surprising result of the groundbreaking caprisa-004 trial, which demonstrated the efficacy of vaginal tenofovir 1% gel in reducing the risk of human immunodeficiency virus (hiv)-1 infection by 39% in heterosexual women, was the added benefit of this microbicide in reducing acquisition of herpes simplex virus type 2 (hsv-2) by 51%. hsv-2 is the most common cause of genital ulcer disease worldwide, and is responsible for considerable morbidity among women and neonates. the virus is further impli ... | 2012 | 22927765 |
| quantifying ongoing hiv-1 exposure in hiv-1-serodiscordant couples to identify individuals with potential host resistance to hiv-1. | immunogenetic correlates of resistance to hiv-1 in hiv-1-exposed seronegative (hesn) individuals with consistently high exposure may inform hiv-1 prevention strategies. we developed a novel approach for quantifying hiv-1 exposure to identify individuals remaining hiv-1 uninfected despite persistent high exposure. | 2012 | 22926009 |
| detection of human herpes viruses in patients with chronic and aggressive periodontitis and relationship between viruses and clinical parameters. | recent microbiological researches have revealed the possible role of human cytomegalovirus (hcmv), epstein barr virus (ebv), and herpes simplex virus (hsv-1 and hsv-2) in the etiopathogenesis of periodontal diseases. the present pilot study has been undertaken to detect the presence of these viruses in chronic periodontitis, aggressive periodontitis, and healthy individuals and to determine the relationship between these viruses and the clinical parameters. | 2012 | 22923891 |
| polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens. | protection against mucosally transmitted infections probably requires immunity at the site of pathogen entry, yet there are no mucosal adjuvant formulations licensed for human use. polyethyleneimine (pei) represents a family of organic polycations used as nucleic acid transfection reagents in vitro and dna vaccine delivery vehicles in vivo. here we show that diverse pei forms have potent mucosal adjuvant activity for viral subunit glycoprotein antigens. a single intranasal administration of infl ... | 2012 | 22922673 |
| structure based molecular design, synthesis and biological evaluation of α-pyrone analogs as anti-hsv agent. | several options for treating herpes simplex virus type 1 and type 2 are available. however, non-specific inhibition and drug resistance warrants the discovery of new anti-herpetic compounds with better therapeutic profile or different mode of action. the non-nucleoside inhibitors of hsv dna polymerase target the site that is less important for the binding of a natural nucleoside or nucleoside inhibitors. in the present study, we have explored the possibility to find a new lead molecule based on ... | 2012 | 22921079 |
| costs and effectiveness of neonatal male circumcision. | to evaluate the expected change in the prevalence of male circumcision (mc)-reduced infections and resulting health care costs associated with continued decreases in mc rates. during the past 20 years, mc rates have declined from 79% to 55%, alongside reduced insurance coverage. | 2012 | 22911349 |
| geldanamycin, a ligand of heat shock protein 90, inhibits herpes simplex virus type 2 replication both in vitro and in vivo. | previously, we discovered geldanamycin, a ligand of heat shock protein 90, effectively inhibited herpes simplex virus type 1 replication in vitro and in vivo (mouse encephalitis model). in this study, we demonstrate that geldanamycin has very strong activities against herpes simplex virus type 2 in vitro and in vivo (mouse vagina model). in mouse vagina model, administration of geldanamycin suspension to vagina after virus infection protected the infected mice from death and increased the averag ... | 2012 | 22909975 |
| deciphering the epidemic synergy of herpes simplex virus type 2 (hsv-2) on human immunodeficiency virus type 1 (hiv-1) infection among women in sub-saharan africa. | herpes simplex virus type 2 (hsv-2) is highly prevalent in regions disproportionately affected by the human immunodeficiency virus (hiv-1) epidemic. the objective of our study was to identify the risk factors of hsv-2 and hiv-1 infections and to examine the association between the two infections. | 2012 | 22909236 |
| cross-sectional assessment of prevalence and correlates of blood-borne and sexually-transmitted infections among afghan national army recruits. | few data are available in afghanistan to shape national military force health practices, particularly with regard to sexually-transmitted infections (stis). we measured prevalence and correlates of hiv, syphilis, herpes simplex 2 virus (hsv-2), and hepatitis c virus (hcv) among afghan national army (ana) recruits. | 2012 | 22909128 |
| 2-[4,5-difluoro-2-(2-fluorobenzoylamino)-benzoylamino]benzoic acid, an antiviral compound with activity against acyclovir-resistant isolates of herpes simplex virus types 1 and 2. | herpes simplex viruses 1 and 2 (hsv-1 and hsv-2) are responsible for lifelong latent infections in humans, with periods of viral reactivation associated with recurring ulcerations in the orofacial and genital tracts. in immunosuppressed patients and neonates, hsv infections are associated with severe morbidity and, in some cases, even mortality. today, acyclovir is the standard therapy for the management of hsv infections. however, the need for novel antiviral agents is apparent, since hsv isola ... | 2012 | 22908173 |
| [the blocking effects of small interfering rnas on rs-1 gene functions of herpes simplex virus type 2: new perspectives for targeted antiviral exposure]. | a new target has been revealed for therapy for herpes simplex type 2. the target is rs1 mrna whose activation is a key stage in regulating the expression of the early genes of herpes simplex virus type 2 (hsv-2). the targeted knockdown of the function of this gene by small interfering rnas (sirnas) has been found to result in the complete suppression of hsv-2 infection. the designed interfering rnas are able to interact with both hsv-1 and hsv-2. the findings suggest that sirnas have protective ... | 2016 | 22905421 |
| influence of methamphetamine on genital herpes simplex virus type 2 infection in a mouse model. | use of the stimulant methamphetamine (meth) is increasingly common, with >35 million users worldwide. there is a known association between stimulant use and an increased incidence of hiv and other sexually transmitted infections (stis). meth is known to have immune modulatory properties. however, the impact of meth on normal immune responses and disease pathogenesis with stis has not been fully examined. | 2012 | 22902670 |
| coverage of hiv prevention components among people with long-standing diagnosed hiv infection in el salvador. | there is scarce information on prevention coverage and management of sexually transmitted infections (stis) in people with hiv in resource-limited settings. | 2012 | 22902664 |
| idiopathic dilated cardiomyopathy and persistent viral infection: lack of association in a controlled study using a quantitative assay. | it remains unclear whether idiopathic dilated cardiomyopathy (dcm) might ensue as the consequence of viral myocarditis, due to viral persistence in cardiomyocytes. to address this issue, we quantified the levels of enterovirus, epstein-barr virus (ebv), herpes simplex virus-1 (hsv-1), herpes simplex virus-2 (hsv-2), adenovirus and parvovirus b19 genomes in endomyocardial biopsies (embs) from patients with dcm, active myocarditis and controls. | 2012 | 22901461 |
| severe primary hsv-2 in a perinatal hiv-infected woman with advanced immunosuppression. | herpes simplex virus type 2 (hsv-2) is most commonly associated with mucocutaneous manifestations; however, coinfections with hiv may be associated with atypical and more severe presentations of clinical disease. we present a case of a young woman with advanced perinatally acquired aids presenting with severe purulent pharyngitis, fevers, and toxic appearance with a subsequent diagnosis of disseminated primary hsv-2 infection in multiple noncontiguous mucocutaneous sites. this case highlights an ... | 2012 | 22899940 |
| acute retinal necrosis caused by herpes simplex virus type 2 in children: reactivation of an undiagnosed latent neonatal herpes infection. | herpes simplex virus type 2 (hsv-2) is known to cause acute retinal necrosis (arn). the availability of hsv-2-specific polymerase chain reaction tests for diagnostic analysis has greatly increased our ability to discriminate arn caused by hsv-2 from arn caused by either herpes simplex virus type 1 or varicella zoster virus (vzv). of great interest, hsv-2 appears to be the most common cause of viral arn in children and adolescents. although a few children with arn are known to have had neonatally ... | 2012 | 22889540 |
| [relationship of cytomegalovirus, chlamydia pneumoniae and herpes simplex virus type 2 infections with preeclampsia]. | to explore the potential relationship of cytomegalovirus (cmv), chlamydia pneumoniae (cp) and herpes simplex virus type 2 (hsv-2) in inflammation and preeclampsia. | 2012 | 22883201 |
| dermal hypersensitivity reaction: a pcr-confirmed pattern of herpetic dermatitis. | herpetic dermatitis due to herpes simplex virus (hsv) and varicella zoster virus (vzv) can present with similar clinical and histopathologic features. further confounding matters, viral cytopathic changes are not always observed in biopsy specimens. therefore, use of polymerase chain reaction (pcr) analysis can play an integral role in the definitive diagnosis of herpetic dermatitis and in the distinction of hsv-1/hsv-2 from vzv. | 2012 | 22882129 |
| prevalences of sexually transmitted infections in young adults and female sex workers in peru: a national population-based survey. | we assessed prevalences of seven sexually transmitted infections (stis) in peru, stratified by risk behaviours, to help to define care and prevention priorities. | 2012 | 22878023 |
| type-specific identification of anogenital herpes simplex virus infections by use of a commercially available nucleic acid amplification test. | herpes infections are among the most common sexually transmitted infections (sti), but diagnostic methods for genital herpes have not kept pace with the movement toward molecular testing. here, we describe an fda-approved molecular assay that identifies and types herpes simplex virus (hsv) infections for use in routine clinical settings. paired samples from anogenital lesions were tested using the bd probetec hsv q(x) (hsvq(x)) system, hsv culture and, a laboratory-developed pcr assay. family pl ... | 2012 | 22875892 |
| correlation between pill counts and biologic effects in an hiv-1 prevention clinical trial: implications for measuring adherence. | clinic-based pill counts of unused study medication are frequently used to measure adherence in hiv-1 prevention trials. monthly pill count adherence data from the partners in prevention hsv/hiv transmission study, a double-blind, placebo controlled trial of twice-daily acyclovir suppression of herpes simplex virus type 2 (hsv-2) in hiv-1 infected persons was used to compare changes between 3,381 placebo and active arm participants in two objective biologic measures of acyclovir's drug activity: ... | 2013 | 22869103 |
| antiviral and immunological effects of tenofovir microbicide in vaginal herpes simplex virus 2 infection. | the anti-hiv microbicide, tenofovir (tfv) gel, has been shown to decrease hiv-1 acquisition by 39% and reduce herpes simplex virus 2 (hsv-2) transmission by 51%. we evaluated the effect of a 1% tfv gel on genital hsv-2 infection in a mouse vaginal challenge model. in vitro plaque assays and luminex multiplex bead analysis were used, respectively, to measure postinfection vaginal viral shedding (day 1) and cytokine secretion (day 2). to further investigate the anti-hsv-2 properties, we evaluated ... | 2012 | 22867119 |
| role of adherens junction proteins in differential herpes simplex virus type 2 infectivity in communication-competent and -deficient cell lines. | gap junctional intercellular communication decreases with hsv-2 infection. to determine the importance of functional gap junctions for infectivity, we compared hsv-2 growth in communication-competent and -deficient cell lines. | 2012 | 22854229 |
| short communication: t cell activation in hiv-1/herpes simplex virus-2-coinfected kenyan women receiving valacyclovir. | herpes simplex virus-2 (hsv-2) suppression with acyclovir or valacyclovir reduces hiv-1 viral rna levels; one hypothesis is that hsv-2 suppression reduces immune activation. we measured t cell immune activation markers among women participating in a randomized placebo-controlled trial of valacyclovir to reduce hiv-1 rna levels among pregnant women. although valacyclovir was associated with lower hiv-1 rna levels, the distribution of both cd4(+) and cd8(+) cd38(+)hla-dr(+) t cells was not differe ... | 2013 | 22852760 |