Publications

tissue culture studies on bacterial hypersensitivity : iv. protective effect of immune plasma against the deleterious influence of streptococcal extract on hypersensitive cells.	1. plasmas from guinea pigs, chronically infected with group c hemolytic streptococci, neutralize the components of bacterial extract which exert a marked toxic action on hypersensitive cells in vitro. 2. the neutralizing capacity of these immune plasmas is relatively specific for the bacterial extract, and is not due to a variable nonspecific effect on normal or hypersensitive tissue cells. 3. a rough correlation between the agglutinin titer and the relative neutralizing capacity of immune plas ...	1937	19870620
studies on pulmonary edema : ii. the pathogenesis of neuropathic pulmonary edema.	1. guinea pigs die shortly after bilateral cervical vagotomy, even when continuous artificial respiration effected through a tracheal cannula is carried out. death is caused by severe pulmonary edema and congestion. 2. direct observation of the lungs after bilateral vagotomy demonstrates that pulmonary edema develops gradually and increases slowly in amount and severity. congestion precedes and accompanies the development of the edema. 3. neuropathic pulmonary edema in the guinea pig is caused b ...	1937	19870672
experimental local bladder edema causing urine reflux into ureter and kidney.	experimental infiltration of the intravesical ureter of the normal bladder in the living, anesthetized animal with magnesium sulfate or physiological salt solution caused a reflux of urine into the ureter in 6 out of 18 guinea pigs (33 per cent); in 22 out of 27 rabbits (81 per cent), and in 14 out of 17 dogs (82 per cent). the vesical pressure necessary to produce this experimental reflux is low and ranges between 2 and 12 mm. of hg; hydrostatic pressure of the bladder contents often sufficed t ...	1937	19870695
studies on the sensitization of animals with simple chemical compounds : iv. anaphylaxis induced by picryl chloride and 2:4 dinitrochlorobenzene.	it has been shown that by the cutaneous administration of simple chemical compounds in small quantities-2:4:6 trinitrochlorobenzene (picryl chloride) and 2:4 dinitrochlorobenzene, the latter a typical incitant of contact dermatitis in man-it is possible to induce true anaphylactic sensitization in guinea pigs, demonstrable by the intravenous injection of protein conjugates and by the dale technique, using isolated uterine horns. this furnishes strong evidence for the formation of antigenic conju ...	1937	19870667
immunological studies on pepsin and pepsinogen.	1. alkali (ph 7.6)-denatured pepsins from swine, cattle, and guinea pigs precipitate in swine pepsin antiserum. similarly treated pepsins from the rabbit, chicken, and shark do not. 2. pepsin antisera react with both pepsin and pepsinogen, but do not react with the serum proteins from the homologous species. 3. pepsinogen antisera react with pepsinogen, but not with twice crystallized pepsin, nor with the serum proteins from the homologous species. positive reactions between activated pepsinogen ...	1937	19873029
studies in blood coagulation : v. the coagulation of blood by proteolytic enzymes (trypsin, papain).	crude or crystalline trypsin in proper concentration causes the blood or plasma of human beings, dogs, rabbits, guinea pigs, and horses to coagulate. it does not clot the fibrinogen directly, but reacts with prothrombin to form thrombin. since trypsin thus has the same effect as the physiological system ca plus platelets (or ca plus tissue extracts), it is suggested as a tentative working hypothesis that the latter system contains a proteolytic enzyme with a specific affinity for prothrombin. ot ...	1937	19873009
the toxicity of sterile filtrate from parodontal pockets: (section of odontology).	the local effect of the absorption of toxic material from pyorrhoea pockets on the hard and soft tissues around the teeth is well known. in this experiment an attempt was made to study the toxic effect on remote structures by injecting the sterile filtrate fresh from pyorrhoea pockets into various animals.the filtrate was obtained from patients with chronic pyorrhoea by removing the contents from parodontal pockets and passing them through a seitz filter. the sterile filtrate obtained was then i ...	1937	19991211
local anaphylactic lesions of the brain in guinea pigs.		1937	19970322
the response of guinea pig bone marrow to liver extract.		1937	19970342
the guinea-pig in the laboratory diagnosis of tuberculosis.		1938	29014294
spontaneous infection of guinea-pigs with a spirillum, presumably spirillum minus carter, 1887.		1938	29014164
a study of the submaxillary gland virus of the guinea pig.		1938	19970392
tuberculosis in allergic and desensitized guinea pigs: a study of histological changes.		1938	19970394
the effect of ascorbic acid deficiency on enamel formation in the teeth of guinea pigs.		1938	19970423
intraperitoneal and intracerebral routes in serum protection tests with the virus of equine encephalomyelitis : iii. comparison of antiviral serum constituents from guinea pigs immunized with active or formolized inactive virus.	earlier experiments had shown that the sera of animals immunized with active virus have much greater protective potency when serum-virus mixtures are injected intraperitoneally into 12 to 15 day old mice than when given intracerebrally. the present work was concerned with similar tests on sera derived from guinea pigs immunized by vaccines in which the virus had been inactivated by formalin. in comparing the content of antiviral body by means of intracerebral and by intraperitoneal inoculation, ...	1938	19870816
intraperitoneal and intracerebral routes in serum protection tests with the virus of equine encephalomyelitis : i. a comparison of the two routes in protection tests.	young (12 to 15 day old) mice are approximately as susceptible to the virus of equine encephalomyelitis, eastern or western strain, when it is given intraperitoneally as are adult mice when the virus is injected intracerebrally. with this susceptibility by the intraperitoneal route as a basis, the injection of immune serum-virus mixtures intraperitoneally was found to result in protection in dilutions which give rise to infection after intracerebral inoculation. the difference of protective powe ...	1938	19870781
factors influencing the persistence of choriomeningitis virus in the blood of mice after clinical recovery.	mice infected in utero continued to carry choriomeningitis virus in the blood more regularly and in greater amount than suckling mice infected by contact. this result may be due to the difference in tissue maturity at the time of infection: the more immature the tissues are when infected, the longer the virus appears to persist in them after maturation. a similar result was obtained with mice of different ages infected either by contact or by intranasal instillation of virus, in that the carrier ...	1938	19870785
cellular reactions to polysaccharides from tubercle bacilli and from pneumococci.	1. purified tuberculo-polysaccharides are relatively innocuous both to normal and to tuberculous guinea pigs. 2. both tuberculo-polysaccharides and polysaccharides from pneumococci call larger numbers of leucocytes from the blood vessels than do saline and dextrose and trehalose. 3. the mechanisms controlling the delivery of lymphocytes and neutrophils into the blood stream are different. 4. slight irritation of the peritoneal lining slows the delivery of lymphocytes to the blood stream. 5. ther ...	1938	19870804
reactions of normal and tuberculous animals to tuberculo-protein and tuberculo-phosphatide.	prior observations on the cellular reactions to tuberculo-phosphatide are confirmed and compared with reactions induced by this material in tuberculous animals. in the latter the response is accelerated and augmented and simulates the koch phenomenon. tuberculo-protein produces no macroscopic reaction in normal animals. the microscopic reaction of neutrophiles and monocytes regresses in less than a week. the same material in tuberculous animals causes a response characterized by more or less hem ...	1938	19870808
tubercular allergy without infection.	1. guinea pigs can be rendered hypersensitive to tuberculo-protein by small, repeated, intradermal injections of active tuberculo-protein. 2. the addition of tuberculo-phosphatide to the protein speeds up the process of sensitization and enhances it so that the reactions become indurated and necrotic, closely simulating those of the disease. 3. active tuberculo-proteins induce a new formation of monocytes and some epithelioid cells. the addition of phosphatide to the protein brings about a massi ...	1938	19870809
studies on eastern equine encephalomyelitis : i. histopathology of the nervous system in the guinea pig.	the action of the virus of equine encephalomyelitis in the guinea pig brain has been studied, and various histological changes have been described in detail. after peripheral inoculation (as in the pad) the earliest detectable pathologic change in the nervous system is the accumulation of leucocytes within the lumen of blood vessels, and the proliferation of the vascular adventitia. this precedes the appearance of any significant perivascular cuffing, and may or may not be accompanied by a few p ...	1938	19870810
a pyogenic filterable agent in the albino rat.	a filterable agent resembling the viruses is described. it was encountered in sarcoma 39, a propagable neoplasm of the white rat, and has now been maintained in this species for 28 passages over a period of some 7 months without appreciable loss in virulence. its chief effect is the production of large abscesses in an animal species comparatively resistant both to viral diseases and suppuration. the white mouse is more susceptible than the white rat, the rabbit less so, and the guinea pig highly ...	1938	19870802
studies on the sensitization of animals with simple chemical compounds : v. sensitization to diazomethane and mustard oil.	with the view of making new types of chemicals accessible for investigations on drug hypersensitiveness, methods have been devised for sensitizing animals with diazomethane and mustard oil, two non-aromatic compounds. guinea pigs have been sensitized to diazomethane, a substance of high reactivity and known to cause severe allergic effects in man. with the second substance, allylisothiocyanate, likewise capable of forming conjugates with substances in the animal body, sensitization effects have ...	1938	19870801
molecular weight, electrochemical and biological properties of tuberculin protein and polysaccharide molecules.	studies have been made by means of sedimentation in the ultracentrifuge, and by diffusion and electrophoresis, to determine the molecular weights and homogeneity of the tuberculin protein and polysaccharide molecules as found in their natural state in the unchanged filtrates from culture media after growth of tubercle bacilli. these results have been compared with data obtained on fractions isolated by chemical procedures from them or from old tuberculin. by means of electrophoresis in the tisel ...	1938	19870796
propagation of the virus of human influenza in the guinea pig fetus.	the pr8 strain of human influenza virus was found to proliferate and disseminate widely in the tissues of fetal guinea pigs inoculated in utero. large quantities of virus free of bacteria were recovered from lung, liver, and placenta, and smaller quantities from blood and brain, after incubation periods ranging from 2 to 6 days. although the fetuses proved to constitute an excellent medium for the propagation of influenza virus, they evinced little gross reaction to the infection. several series ...	1938	19870790
altered cutaneous conditions in the skin of tuberculous guinea pigs as demonstrated with a vital dye.	1. in the skin of the tuberculous guinea pig while it is allergic, the spread of a vital dye, pontamine sky blue, and the drainage of the dye into the vascular system take place much more slowly than in the normal animal. 2. in the skin of moribund tuberculous guinea pigs, animals no longer allergic, dye spreads more rapidly than in the normal animal. 3. the spread of dye is somewhat restricted in the skin of guinea pigs infected with a hemolytic streptococcus. the animals were allergic. 4. the ...	1938	19870791
anaphylactic shock by azodyes. ii.	from the experiments presented, it follows that the specific precipitation and the production of anaphylactic shock with certain azodyes, as described previously, is due to these substances themselves and is not dependent upon formation of azoproteins by interaction of the dyes with proteins in the test tube or the animal body. besides these, some other azodyes which in our tests did not give precipitation with corresponding immune sera were also found, in very small quantities, to induce anaphy ...	1938	19870711
anaphylaxis in the isolated heart.	the isolated hearts of guinea pigs sensitized to horse serum have been shown to react characteristically upon exposure to small amounts of antigen. the cardiac rate is temporarily accelerated and transient alterations in amplitude of contraction are to be observed. electrocardiographic abnormalities, previously recorded by remote leads during anaphylactic shock in the intact animal, have been recorded by direct leads from the isolated perfused hearts of sensitized animals during this reaction. a ...	1938	19870713
a growth inhibitory substance for the influenza group of organisms in the blood of various animal species : the use of the blood of various animals as a selective medium for the detection of hemolytic streptococci in throat cultures.	1. 5 per cent sheep blood agar is a selective medium for beta hemolytic streptococci in throat cultures since sheep blood inhibits the growth of bacillus x (h. hemolyticus) and b. parainfluenzae hemolyticus. the growth of h. influenzae is also inhibited by sheep blood. 2. the inhibitory action of sheep blood resides in the erythrocytes and is thermolabile. disruption of the cell by laking has no effect upon the inhibitor. 3. the bloods of animals closely related to the sheep, such as the goat an ...	1938	19870730
immunization of guinea pigs against lymphocytic choriomeningitis with formolized tissue vaccines.	guinea pigs can be immunized against lymphocytic choriomeningitis by 2 or 3 injections with formolized vaccines prepared from a variety of infected guinea pig tissues. vaccines prepared from the consolidated areas of diseased lungs gave the best results. the immunity produced was partial in the majority of the cases, in that the vaccinated animals as a rule showed fever after the test of immunity and virus was present in the circulation during the febrile period. vaccines prepared from infected ...	1938	19870778
an unidentified virus producing acute meningitis and pneumonitis in experimental animals.	an infectious agent is described which belongs apparently to the class of filtrable viruses, but which, on the basis of the evidence at hand, is not to be identified with any virus previously described. the virus has multiple tropisms and is pathogenic for mice, ferrets, and monkeys of both m. rhesus and m. cynomolgos species. intranasal infection of mice and ferrets causes extensive pneumonic lesions of fatal severity. intracerebral inoculation of the virus produces in monkeys a lymphocytic cho ...	1938	19870779
influence of host factors on neuroinvasiveness of vesicular stomatitis virus : iv. variations in neuroinvasiveness in difierent species.	peripheral inoculation of vesicular stomatitis virus is constantly followed by myelitis or encephalitis in young mice, but not in young (or old) guinea pigs. the cause of this variation was elucidated by investigating the fate of the virus after inoculation by a number of different routes. direct intracerebral injection of minimally infective amounts of virus was found to be equally fatal for young mice and young guinea pigs, indicating that the central nervous system as a whole was as easily in ...	1938	19870716
sulphanilamide for tuberculosis in guinea-pigs.		1938	20781805
the effects of age and hormones on the stroma of thyroid and mammary gland in the guinea pig.		1938	17752345
the electrocardiogram of the guinea-pig.		1938	16994973
the effect of high doses of androgenic substances on the weights of the testes' accessory reproductive organs and endocrine glands of young male guinea-pigs.		1938	16995033
the physiological properties of ascorbic acid: an effect upon the weights of guinea-pigs.		1938	16746755
the physiological properties of ascorbic acid: effects upon water balance and upon body composition of guinea-pigs.		1939	16746956
the physiological properties of ascorbic acid: the increase in metabolism of guinea-pigs on a diet deficient in ascorbic acid.		1939	16746918
treatment of gas gangrene infections in guinea-pigs with neoprontosil, sulfanilamide, and sulfapyridine: an experimental study.		1939	16694690
histamine release in anaphylactic shock from various tissues of the guinea-pig.		1939	16995097
a quantitative study of genic effects on guinea-pig coat colors.		1939	17246926
studies on the tricolor pattern of the guinea pig. i. the relations between different areas of the coat in respect to the presence of color.		1939	17246940
studies on the tricolor pattern of the guinea pig. ii. the distribution of black and yellow as affected by white spotting and by imperfect dominance in the tortoise shell series of alleles.		1939	17246941
investigation of the physiological genetics of hair and skin color in the guinea pig by means of the dopa reaction.		1939	17246942
inheritance of internal organ differences in guinea pigs.		1939	17246946
role of vitamin e in the prevention of muscular dystrophy in guinea pigs reared on synthetic rations.		1939	17798919
a comparative study of the mouse and guinea pig inoculation methods in the diagnosis of rabies.		1939	18015094
similarity of chronic infections with salmonella typhimurium and tuberculosis in guinea pigs.		1939	18015121
the elimination of virulent tubercle bacilli by the normal kidney of the guinea pig.		1939	21407585
studies on the mechanism of immunity in tuberculosis : the mobilization of mononuclear phagocytes in normal and immunized animals and their relative capacities for division and phagocytosis.	1. tuberculous and vaccinated rabbits and guinea pigs mobilize mononuclear phagocytes at the site of a non-specific inflammation with greater rapidity than do normal animals, just as they respond to tubercle bacilli. 2. the succession of cells that characterizes inflammation in general is accelerated in allergic rabbits and guinea pigs in response to non specific irritants. 3. the ph at the site of reinfection with tubercie bacffli in immun ized rabbits and guinea pigs and at the site of a non-s ...	1939	19870865
the effects of anaphylaxis, and of histamine, upon the coronary arteries in the isolated heart.	anaphylaxis in the isolated, perfused hearts of cats has been shown to be accompanied by a considerable, though transient, increase in coronary flow. this result is contrasted with that observed in the hearts of guinea pigs and rabbits in which the coronary arteries are constricted during anaphylaxis. attention is directed to the fact that, in the hearts of these three species, the effects of anaphylaxis and of histamine are qualitatively parallel. the characteristic anaphylactic response in the ...	1939	19870863
encephalopathy following injections of bone marrow extract.	monkey bone marrow extract when injected intracerebrally into guinea pigs or rabbits produces a distinctive encephalopathy. the purkinje cells are severely affected, especially those at the periphery of the cerebellum. nuclear alterations first appear, with well marked intranuclear acidophilic inclusion bodies. similar inclusions appear at a little later stage in the ectodermal glia. the affected cells later become necrotic and usually disappear. the reaction is essentially glial and non-inflamm ...	1939	19870911
the reticulo-endothelial system and hormone refractoriness.	1. young splenectomized female rats, free of latent infection, show greater increases in ovarian weight in response to injections of pregnant mare's serum than do young normal rats with spleens intact. 2. the regression in ovarian weight which occurs after about a month in such injected splenectomized animals may be prevented by repeated injections of an agent like trypan blue which causes blockage of the compensating reticulo-endothelial elements. 3. the plasmas obtained from these splenectomiz ...	1939	19870913
hemolytic streptococcus lymphadenitis in guinea pigs.	a group of guinea pigs carrying a chronic streptococcus cervical lymphadenitis has been studied. the chronic disease may be transmitted with pure cultures of streptococci isolated from the naturally occurring abscesses. its probable mode of transmission under natural conditions was shown to be the ingestion of the infective agent. the spontaneous appearance of an acutely fatal variant was observed. infection with the chronic strains protected animals against the highly virulent strain. such immu ...	1939	19870914
studies on the sensitization of animals with simple chemical compounds : vi. experiments on the sensitization of guinea pigs to poison ivy.	experiments are described on the latency period in sensitization to poison ivy and on the time necessary for the agent to remain in contact with the skin. the chief matter of investigation concerned the manner in which the whole skin becomes sensitive following treatment at a particular site, and especially whether this is effected by way of the epidermis. two methods were used to interrupt the continuity of the skin, one by cutting through both skin and the underlying thin muscular layer, the o ...	1939	19870876
studies on eastern equine encephalomyelitis : iii. intraocular infection with fixed virus in the guinea pig.	the behavior of a fixed strain of eastern equine encephalomyelitis virus was studied in guinea pigs after intraocular inoculation. such inoculation concerns the central and not the peripheral nervous system. the susceptibility to intraocular injection lies midway between the highly virulent intracerebral and the quite avirulent peripheral routes. the virus must act for 10 to 13 hours in order to induce a fatal infection. removal of the inoculated eyeball before this interval almost always preven ...	1939	19870871
experiments on histamine as the chemical mediator for cutaneous pain.	experimental evidence shows that histamine is liberated when the upper layers of the skin are stimulated in the threshold range although no gross or microscopic evidence of tissue damage is demonstrable. a histamine-like substance is recoverable from the anterior chamber of the rabbit's eye on electrical stimulation of the cornea. this substance is liberated in direct proportion to the intensity of the stimulus. histamine when injected intradermally or applied to the denuded skin (less epidermis ...	1939	19870919
experimental production of digestive tract ulcerations.	we have attempted to reproduce in animal experiments a group of pathological findings which we have observed to be associated with shock. in order to simulate the compensatory vasomotor reactions occurring in shock, we have utilized the intraperitoneal injection of adrenalin hydrochloride in dogs, cats, rabbits and guinea pigs. that the effect of adrenalin hydrochloride when injected by this route is of long duration has been shown by the prolonged hyperglycemia which it produces. our experiment ...	1939	19870922
a soluble antigen of lymphocytic choriomeningitis : i. separation of soluble antigen from virus.	the virus of lymphocytic choriomeningitis can be sedimented in the ultracentrifuge and washed repeatedly; the virus retains its activity provided that a small amount of normal serum is present in the diluent. a soluble substance capable of fixing complement in the presence of immune serum can be separated from the virus. washed virus fixes complement poorly. the serologically specific soluble antigen is widely distributed in tissues of infected guinea pigs, mice, and monkeys.	1939	19870890
lung edema following bilateral vagotomy : studies on the rat, guinea pig, and rabbit.	1. small animals (rat and guinea pig) vagotomized in the neck die within a period of hours, the lungs showing extensive congestion and edema. 2. tracheotomy permits appreciably longer survival with minimal lung changes approximating those seen in the control animals. 3. intrathoracic vagotomy (sparing the recurrent laryngeal nerve) on one side, and cervical vagotomy on the other, permits almost indefinite survival (guinea pig and rabbit), unless laryngeal paralysis from the unilateral denervatio ...	1939	19870894
studies on the mechanism of immunity in tuberculosis : the role of extracellular factors and local immunity in the fixation and inhibition of growth of tubercle bacilli.	1. the fate of bacilli of reinfection at the portal of entry and in metastatic foci, and also the associated host responses, are essentially similar in rabbits and guinea pigs. 2. however, in the guinea pig tubercle bacilli of reinfection are more effectively fixed at the portal of entry than in the rabbit. 3. the guinea pig fixes at the site of reinfection unrelated substances, such as trypan blue and agar particles, more effectively than the rabbit. 4. at the site of a local non-specific infla ...	1939	19870864
studies on eastern equine encephalomyelitis : ii. pathogenesis of the disease in the guinea pig.	after inoculation with equine encephalomyelitis virus by various routes, guinea pigs were sacrificed at early stages, before symptoms were apparent. the brains were studied histologically, with serial sections; all lesions were noted, and subjected to topographical analysis. nine cases are presented in detail. with any given mode of inoculation the distribution of lesions varied very widely from one instance to another. in some cases, affected regions bore a striking and definite anatomical rela ...	1939	19870870
studies on the purification of bacteriophage.	a simple method of concentrating and purifying bacteriophage has been described. the procedure consisted essentially in collecting the active agent on a reinforced collodion membrane of a porosity that would just retain all the active agent and permit extraneous material to pass through. advantage was taken of the fact that b. coli will proliferate and regenerate bacteriophage in a completely diffusible synthetic medium with ammonia as the only source of nitrogen, which permitted the purificatio ...	1939	19873149
growth processes in cartilage and bone subsequent to gonadectomy and administration of anterior pituitary extract of cattle in immature male and female guinea pigs.		1939	19970433
studies on the pathogenicity and cytological reactions of the submaxillary gland virus of the guinea pig.		1939	19970451
a comparison of the effects of anterior pituitary hormone on skeletal tissues of young and mature guinea pigs.		1939	19970471
intracutaneous inoculation of guinea-pigs for the diagnosis of tuberculosis.		1940	29013922
the transmission of lymphogranuloma venereum to the guinea pig.		1940	19970493
effects of ovariectomy and long continued administration of anterior pituitary extract of cattle on skeletal tissues of immature guinea pigs.		1940	19970519
the effect of thyroidectomy and administration of anterior pituitary extract of cattle on the growth of cartilage and bone of immature guinea pigs.		1940	19970520
the tissue specificity of brain and medullated nerves as shown by passive anaphylaxis in guinea pigs.	prolonged immunization of rabbits with a sedimented, heat-killed vaccine of pasteurella boviseptica grown in an infusion broth prepared from rat brain resulted in the production of antisera containing antibodies for the broth as well as for the bacteria. when guinea pigs were prepared by intra-abdominal injection with such antisera and tested 24 hours later by intravenous injection with autoclaved extracts of different organs and tumors of rats, they were found to be passively sensitized, so tha ...	1940	19871039
studies on the sensitization of animals with simple chemical compounds : viii. sensitization to picric acid; subsidiary agents and mode of sensitization.	sensitization of guinea pigs to picric acid was obtained by application of oil solutions to the skin, preferably on inflamed sites or by treatment with a compound of picric acid with n-butyl-p-aminobenzoate. the lesions obtained in sensitive animals on superficial administration bore resemblance to human eczema. it seems probable that picric acid sensitization is an instance where a substance does not sensitize directly but after conversion into a more reactive compound, a principle which should ...	1940	19871030
a soluble antigen of lymphocytic choriomeningitis : ii. independence of anti-soluble substance antibodies and neutralizing antibodies, and the role of soluble antigen and inactive virus in immunity to infection.	anti-soluble substance antibodies and neutralizing substances, which develop following infection with the virus of lymphocytic choriomeningitis, appear to be separate entities. the times of appearance and regression of the two antibodies are different in both man and the guinea pig; the antisoluble substance antibodies appear earlier and remain a shorter time. moreover, mice develop them but no demonstrable neutralizing substances. injection of formalin-treated, virus-free extracts containing co ...	1940	19871032
a soluble antigen of lymphocytic choriomeningitis : ii. characteristics of the antigen and its use in precipitin reactions.	the soluble antigen of lymphocytic choriomeningitis which is readily separable from the virus is a relatively stable substance and appears to be of a protein nature. a specific precipitin reaction can be demonstrated when immune serum is added to solutions of antigen which have been freed of certain serologically inactive substances. the complement-fixation and precipitation reactions which occur in the presence of immune serum and non-infectious extracts of splenic tissue obtained from guinea p ...	1940	19870943
the inhibition of the bacteriostatic action of sulfonamide drugs by substances of animal and bacterial origin.	sulfonamide inhibitor has been demonstrated in extracts of fresh normal muscle, pancreas, and spleen of certain animals. when autolysis of tissues takes place the amount of inhibitor is greatly increased. fresh liver from beef, rabbit, and guinea pig is free of active inhibitor, although inhibitor is demonstrable in autolysates of this tissue. fresh rabbit kidney is likewise free of active inhibitor. following acid hydrolysis extracts of fresh rabbit liver and kidney cause sulfonamide inhibition ...	1940	19871019
studies of a murine strain of poliomyelitis virus in cotton rats and white mice.	1. a neurotropic murine virus was isolated by passing poliomyelitis virus (sk strain) from the monkey to cotton rats and white mice. 2. the murine virus has been grown in tissue culture consisting of embryonic mouse brain in ox serum ultrafiltrate. 3. the symptoms and lesions produced by the murine infection compare in all respects with those of poliomyelitis in monkey and man. 4. the murine virus, while highly pathogenic for mice and cotton rats, is non-pathogenic for albino rats, guinea pigs, ...	1940	19871033
studies on the cultivation of the virus of lymphogranuloma venereum.	two strains of the lymphogranuloma venereum virus were maintained in tissue cultures for 12 and 21 generations respectively. in a third strain a quantitative increase in potency as high as 1000 times was obtained by inoculating tissue cultures with infected emulsions of known virulence. greater increases in potency were consistently obtained by maintaining tissue cultures and virus at room temperature (23 degrees c. with a range of approximately +/- 5 degrees c.) than by incubating them at 37 de ...	1940	19870939
a latent virus in normal mice capable of producing pneumonia in its natural host.	1. a virus capable of producing fatal pneumonia in mice has been isolated repeatedly from the lungs of certain apparently healthy mice. not all mice carry the virus. it was obtained only from mice supplied by three breeders although mice from eight different sources were studied. 2. the virus was avirulent as it occurred in normal mouse lungs and became virulent only after serial mouse lung passage. it was strictly pneumotropic for mice and produced pneumonia when given intranasally but showed n ...	1940	19870970
infection of guinea pigs by application of virus of lymphocytic choriomeningitis to their normal skins.	as shown in table i, 97 guinea pigs were used in this study. fifty-seven were exposed by placing a virus suspension on their normal skins. of this number, 34 had screw-top capsules attached to them. thirteen were exposed by spreading the virus suspension on their feed and cage litter. ten were inoculated intracerebrally to establish the potency of the virus. the remaining 17 were not exposed artificially to the virus and were employed as controls to detect cross infection. twenty-two guinea pigs ...	1940	19871028
the recovery from patients with acute pneumonitis of a virus causing pneumonia in the mongoose.	1. a virus capable of producing pulmonary consolidation in the wild mongoose (herpestes griseus) has been isolated from throat washings obtained from four patients with a clinical syndrome termed acute pneumonitis. 2. the virus was not pathogenic for ferrets, mice, guinea pigs, rabbits, monkeys, voles, hamsters, deer mice, skunks, opossums, or woodchucks. 3. the virus was filterable through berkefeld v and n candles, was not inactivated by glycerin or by freezing and drying in vacuum, and was pr ...	1940	19871045
the comparative susceptibility of fetal and postnatal guinea pigs to the virus of epidemic influenza.	experiments were carried out to determine the relative susceptibility of guinea pigs at different ages to the virus of epidemic influenza. from a correlation of these studies on the mature fetus, the newborn, and the adult animal, with previously reported findings on the immature fetus, we draw two conclusions: first, that there is a gradually increasing resistance to infection with this virus during intrauterine development, with but little change thereafter; and second, that at the time of bir ...	1940	19871047
treatment with sulphapyridine (m&b 693) of guinea-pigs infected with brucella abortus.		1940	20782898
reversed passive anaphylaxis in the guinea-pig.		1940	20475548
methods of inoculating the guinea pig through various channels.		1940	18015278
a colorimetric study of genic effect on guinea-pig coat color.		1940	17246965
the action of adrenaline upon the uterus of the guinea-pig and its modification by eserine.		1940	16995222
bronchomotor responses to stimulation of the stellate ganglia and to injection of acetylcholine in isolated perfused guinea-pig lungs.		1940	16995235
the use of bacteriophage for freeing protozoal cultures of contaminating bacteria: isolation of leptospira icterohœmorrhagiæ from a mixed infection in guinea-pigs.		1941	29013667
the behaviour of the pregnant uterus of the guinea pig.		1941	16991525
genetic aspects of pigment production in the guinea pig.		1941	17247018
tests for linkage in the guinea pig.		1941	17247027
the action of l-ascorbic acid on the in vitro respiration of liver tissue from guinea-pigs on a restricted diet. i.		1941	16747364
the action of l-ascorbic acid on the in vitro respiration of liver tissue from guinea-pigs on a restricted diet. ii.		1941	16747365
the h-ion concentration and the origin of the heart beat.	the rate of the frog or guinea pig heart preparation was not significantly influenced by the h-ion concentration when this was kept within limits which allowed the heart to continue beating. the theory that the h-ion concentration is intimately concerned with the origination of the heart beat is not supported by the results of this investigation.	1941	17787442
studies on photo-oxidation of antigen and antibodies.	1. quantitative precipitin studies indicate that progressive photo-oxidation progressively destroys the antigenic function of egg albumin. 2. quantitative precipitin reactions of antisera (anti-egg albumin rabbit serum and antipneumococcus type i horse serum) demonstrate that progressive photo-oxidation causes progressive lowering of the potency of the sera. 3. quantitative precipitin reactions of the photo-oxidized globulin gamma fraction of anti-egg albumin rabbit serum and of felton solution ...	1941	19871074
heterologous transplantation of mammalian tumors : i. the transfer of rabbit tumors to alien species.	a series of experiments was undertaken in an attempt to transplant rabbit tumors to animals of alien species using the anterior chamber of the eye as an inoculation site. the uterine tumor h-31 and the breast tumors t-36 and b-240 were successfully transplanted to all the various animals tried, including guinea pigs, swine, goats, and sheep, and the h-31 and t-36 tumors were maintained by serial transfer in the two first species. on the other hand, all attempts to transfer the brown-pearce tumor ...	1941	19871090
quantitative chemical studies on complement or alexin : iii. uptake of complement nitrogen under varying experimental conditions.	1. quantitative data are given on the effect of variations in the time of contact and the proportions of the reactants on the quantity of complement combining component nitrogen (c'1 n) found in active guinea pig serum. 2. c'1 n was the same when determined with precipitates containing excess antibody or excess antigen. 3. finely divided specific precipitates took up the complement combining component (c'1) from subsequently added guinea pig serum almost as well as specific precipitates formed i ...	1941	19871140
the complement fixation test in the diagnosis of virus infections of the central nervous system.	a specific complement fixation test can be obtained in various central nervous system virus infections by using as antigens emulsions of infected brain tissue, freezing and thawing the brain emulsion, and then centrifuging it in an angle head centrifuge at 3500 r.p.m. for 1 hour. the method has proved reliable in the case of rabies, st. louis encephalitis, japanese b encephalitis, lymphocytic choriomeningitis, eastern equine encephalomyelitis, western equine encephalomyelitis, louping ill, and s ...	1941	19871144
the effect of a polysaccharide-splitting enzyme on streptococcal infection.	1. confirming the observations of other experimenters, it has been found that group a hemolytic streptococci produce a capsule containing a polysaccharide which is similar to, if not identical with, certain high molecular weight sugars found in the mammalian body. 2. leech extract possesses a powerful enzyme capable of splitting one of the linkages in this polysaccharide and of decapsulating group a and group c hemolytic streptococci in vitro and in vivo. 3. mice and guinea pigs can be protected ...	1941	19871093