Publications

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an elisa for the detection of maedi/visna antibody. 1979228467
[interaction between foot-and-mouth disease virus and the cells of different chronically infected animals]. 1979228472
characterization of mg2+-atpase from sheep kidney medulla: magnetic resonance and kinetic studies. 1979228607
[use of immobilized proteinases for purification of sheep smallpox virus].a possible use of papain and trypsin immobilized on biogel p-100 for purification of dna-containing sheep smallpox viruses was studied. it was shown that the enzymes depolymerize tissue proteins, resulting in a 90% purification of the viruses without causing any considerable morphological changes in the virion structure. it was concluded that fixed proteinases can be effectively used at the final stage of purification of tissue virus-containing suspensions.1979228769
thyrotropin releasing hormone: apparent receptor binding in retina. 1979228960
concentration, synthesis and utilization of phosphoribosylpyrophosphate in lymphocytes of five mammalian species. 1979229007
modification in vitro of cholesterol content of sheep liver nuclear envelope [proceedings]. 1979229042
recent advances in viral zoonoses. 1979229080
incidence of bluetongue virus precipitating antibodies in sera of some domestic animals in the sudan.to determine the presence and prevalence of bluetongue (bt) infection in a variety of domestic animal species in different geographical regions of the sudan, a serological study using the agar gel precipitation technique was initiated. a total of 2142 serum samples were examined. of the numbers tested approximately 28% of sheep, 11.2% of goats, 8% of cattle and 4.9% of camels were positive for group-specific antibodies to bt virus antigen, indicating previous exposure to bt infection. none of th ...1979229163
possible origin of the bluetongue epidemic in cyprus, august 1977.possible origins of an epidemic of bluetongue in cyprus in august 1977 have been analysed. first outbreaks occurred simultaneously in the south-east of the famagusta district and on the north coast of the kyrenia district respectively. although the epidemic was due to type 4, which had been responsible for the previous outbreak in 1969, no evidence of persistance of virus could be found. imports of domestic animals in the past year were not implicated since the imported cattle were introduced on ...1979229164
catecholamine and cyclic nucleotide response of sheep to the injection of clostridium welchii type d epsilon toxin.injection of clostridium welchii (c. perfringens) type d epsilon toxin into sheep caused large increases in catecholamine and cyclic adenosine 3',5'-monophosphate levels and moderate increases in cyclic guanosine 3',5'-monophosphate levels. haemoconcentration also occurred. it is suggested that a rapidly developing brain oedema is the stimulus for a release of catecholamines which in turn activates adenyl cyclase. the resulting rise in camp causes glycogenolysis and hyperglycaemia.1979229224
regulation of oxytocin action at the receptor level. 1979229376
[cultivation of rotavirus, agent of neonatal diarrhea in calves]. 1979229623
action of mannitol in various immunological experimental models.the authors describe the inhibiting action of mannitol after repeated administration of low subcutaneous doses in a number of experimental immunological models. for example, in the rat it produces a reduction of the secondary arthritis of freund's adjuvant polyarthritis and also of the pleurisy due to bordetella pertussis hypersensitivity. in the mouse it reduces the reaction of delayed hypersensitivity to sheep red cells. its action is also marked against ovalbumin-induced active skin anaphylax ...1979229721
effect of acth on the aldosterone response to potassium in sheep with adrenal transplants.the importance of physiological acth stimulation in maintaining the response of aldosterone secretion to potassium was studied in 5 conscious sheep with cervical adrenal autotransplants. endogenous acth secretion was suppressed by dexamethasone. constant local infusions of potassium that raised adrenal venous plasma by 2 mmol/l increased aldosterone secretion from 3 +/- 1 ng/min (mean +/- se) to levels of 50 +/- 13 ng/min at 30 min, after which secretion fell to 14 +/- 6 ng/min at 230 min. addit ...1979229735
fate of herpes simplex virus in lymphocytes from inflammatory joint effusions. ii. mechanisms of non-permissiveness.mononuclear cells which were isolated from rheumatoid synovial effusions and cultured without prior separation failed to support the growth of herpes simplex virus (hsv). however, subpopulations of t lymphocytes separated on the basis of cell size or receptors for sheep red cells were, in isolation, permissive for this virus. virus growth in these permissive cells was blocked by cocultivation with the remaining mononuclear cell populations.1979229778
quantification of pituitary membrane receptor sites to lhrh: use of a superactive analog as tracer. 1979229833
antiserum against rat luteinizing hormone (lh) receptors. 1979229838
interaction of gnrh with anterior pituitary. iii. role of divalent cations, microtubules and microfilaments in the gnrh activated gonadotroph. 1979229920
inhibition of spontaneous rosette formation with sheep red blood cells after adherence of fibroblasts to the substrate. 1979230095
ultraviolet-induced carcinogenesis in mice treated with silica, trypan blue or pyran copolymer. 1979230348
effect of palmitylcarnitine on ouabain binding to na, k-atpase. 1979230355
human cell lines containing epstein-barr virus but distinct from the common b cell lymphoblastoid lines.a group of very similar cell lines was established from peripheral blood or bone marrow of 12 patients with a variety of disorders. the cells in these cell lines were uniform and round in shape. they grew as single-cell suspensions or as aggregates of small numbers of cells in stationary culture. the most striking characteristic of these lines was the lack of cells with surface immunoglobulin or with demonstrable immunoglobulin synthesis. this lack of immunoglobulin synthesis and their special g ...1979230517
human lymphocyte subpopulations. 1979230533
the effect of prostaglandin e2 infusion in the fetal lamb on fetal plasma acth, prolactin and cortisol concentrations.pge2 (2 micrograms/min) has been infused for 1h into the fetal jugular vein of 8 chronically catheterized fetuses on 13 occasions from 112 to 138 days gestation. infusion of ethanol vehicle alone was conducted in fetuses from 111-139 days gestation. pge2 administration produced a significant increase in fetal plasma cortisol after 30 min. no significant change was observed in fetal plasma prolactin concentration. fetal plasma acth concentration was significantly elevated above resting concentrat ...1979230537
[zinc activated tartrate resistent phosphatases in the brains of different animal species and their characterization].a zinc activated tartrate resistent phosphatase (zntp) of the brain of different animal species was separated by electrofocusing in polyacrylamide gels. it is demonstrable selectively in the presence of 20 mm zinc acetate and 10 mm d,l-sodium tartrate or of 100 mm zinc acetate only. the zntp hydrolyzes 1-naphthyl phosphate and 4-nitrophenyl phosphate, respectively. high activity of zntp is evident in the brains of rats and rabbits. the activity is moderate or absent in the brains of mice, syrian ...1979230670
production of human leukocyte interferon for clinical use under immunoelectrophoretic control.human leukocyte interferon (hlif) can be contaminated by several antigens which may include also potentially pathogenic agents. for this reason, gel filtration as a separation method was included into the routine procedure of preparation and purification of hlif for clinical use. since production of hlif requires the cultivation of leukocytes in the presence of serum (or albumin), serum proteins represent then the majority of proteins contaminating if preparations. measuring the total protein co ...1979230675
the effects of acth on lung maturation in fetal lambs.the ability of adrenocorticotrophic hormone (acth) to induce lung maturation was evaluated in fetal lambs. one member of 14 twin pairs between 114 and 138 days of gestation was infused intravenously with 0.5 mg acth over 5 days. the lungs of treated versus control lambs were judged more mature by morphologic criteria by the use of light and electron microscopy and by biochemical criteria by the use of lamellar-body-rich cell fractions. none of 5 premature lambs treated with acth and allowed to b ...1979230741
temporal appearance, geographic distribution, and species of origin of bluetongue virus serotypes in the united states.beginning in 1973, all available laboratory and field strains of bluetongue virus (btv) from the united states were serotyped. of the viral strains serotyped, 27 were collected from 1953 through 1972; 173 were collected from 1973 through 1977. although 20 btv serotypes have been found worldwide, only btv serotypes 10, 11, 13, and 17 have been found in the united states. since 1973, serotypes 11 and 17 have been the prevalent serotypes. samples were collected over a 24-year period in the united s ...1979230763
microbiology of bruised tissue.no significant differences could be found in the microbial quality of bruised and unbruised tissue provided that the two types of tissue were treated identically. this suggests that there is no good reason for the condemnation of bruised tissue, which could well be used in manufactured products.1979230787
studies on the control of respiration and behaviour during development in ewe-reared lambs.radiotelemetric recordings have been made in a series of newborn lambs with implanted electrodes and transducers and an external back-pack transmitter. cardiac, respiratory and behavioural data have been gathered. these data have been analysed firstly with respect to age. the cardiac and respiratory data have then been related to both sleep state and age. an unexpected rise in both heart and respiratory rates was found after birth and marked differences were obvious in respiratory control in rem ...1979230868
[evidence for the production of a fusion factor during in vitro infection of sheep choroid plexus cells by visna virus].one of the most important early events during the infection of sheep choroïd plexus cells in culture by visna virus is the synthesis by these cells of a fusion factor distinct from the virus. the cell fusion activity of this factor does not seem transmissible. it promotes cell shape changes and a migration of the nucleus towards the cell wall.1979230888
evaluation of functional thymic hormones in arabian horses with severe combined immunodeficiency.arabian horses with severe combined immunodeficiency disease (scid) were evaluated for thymic hormone activities using thymic extracts and sera. extracts prepared from thymus of scid horses were able to increase the number of spleen cells responding to sheep red blood cells in irradiated, bone marrow-reconstituted mice. in addition, ultrafiltrates prepared from sera of these immunodeficient horses, which contained material with molecular weight of less than 50,000 daltons could (a) induce a popu ...1979230925
pathology of an experimental infection of specific pathogen-free lambs with parainfluenza virus type 3 and pasteurella haemolytica. 1979231053
experimental challenge infection of ewes following a field outbreak of border disease. 1979231054
e rosettes in the uranium miners with lung cancer.rosette forming cells (rfc) were evaluated in the peripheral blood of healthy persons, patients with lung cancer and chronic bronchitis. simultaneously the levels of rfc in persons with and without radiation exposure were compared. two types of rosettes were enumerated: 1) lymphocytes binding 1 or 2 sheep red blood cells (srbc), 2) lymphocytes binding 3 or more srbc. then the sum of both types was calculated. the patients with lung cancer were divided according to the tnm classification and hist ...1979231508
surface markers and functional characteristics of human blood lymphocytes residing in the operational "null" subset.after removal of nylon wool-adherent b and e rosetting t cells from the human blood lymphocyte population, a small fraction remains, often denoted as "null" subset. this fraction contains lymphocytes which are highly efficient in antibody-dependent and non-selective lymphocyte cytotoxicity. these cells possess markers. about half of them carry fc receptors, and the majority has low avidity e and c3 receptors. removal of low avidity e receptor-carrying cells did not abolish cytotoxicity to k-562 ...1978231548
antibody to rotavirus in various animal species. 1979231743
[role of mast cells in the development of immunologic reactions]. 1979231870
t and b lymphocyte subpopulations and leukocyte terminal deoxynucleotidyl-transferase in energy-protein undernutrition.children with energy-protein undernutrition showed a reduction in the number of circulating t lymphocytes identified on the basis of their ability to form rosettes with sheep red blood cells. t cells with a receptor for igm (tmu) were decreased whereas t cells with a receptor for igg (t gamma) were increased. surface immunoglobulin bearing b cells were comparable in well nourished and malnourished subjects but the proportion of b alpha was increased in the latter. "null" cells without the conven ...1979231889
slow viral infections. 1979231926
haemodynamics of acth-induced hypertension in sheep.1. administration of adrenocorticotropic hormone (acth) to sheep produced increases in mean arterial pressure within 24 h associated with an increase in cardiac output and cardiac rate. both cardiac output and blood pressure remained elevated over the 5 days of acth treatment. 2. administration of acth during beta-adrenoreceptor blockade resulted in an increase in blood pressure without changes in cardiac output at 24 h. 3. administration of a combined steroid infusion over 5 days produced incre ...1979232025
progressive pneumonia in sheep: incidence of natural infection and establishment of clean flocks. 1979232098
autophagy and apoptosis in liver during the prehaemolytic phase of chronic copper poisoning in sheep. 1979232106
immunosuppression in experimental trypanosomiasis: effects of trypanosoma brucei on immunization against louping-ill virus and lymphocytic choriomeningitis virus. 1979232108
comparison of four-layer radioimmunoassay and electron microscopy for detection of human rotavirus.a four-layer radioimmunoassay (ria) using polystyrene beads as the solid phase, anti-rota guinea pig igg as primary antibody, anti-rota rabbit igg as secondary antibody, and 125i-labelled sheep anti-rabbit immunoglobulin as indicator antibody has been developed for the detection of human rotavirus in stool specimens. a comparison was made of the developed ria, routine electron microscopy, and research electron microscopy of 147 unconcentrated stool specimens from patients with infantile gastroen ...1979232141
[cysticercus in animals slaughtered in the port-bouet abattoir (abidjan)]. 1978232291
detection of antibodies against glycoprotein of maedi-visna virus released as soluble antigen in cell cultures. 1979232343
receptor binding, biological, and immunological properties of chemically deglycosylated pituitary lutropin. 1979232401
[etiology and immunoprophylaxy problems in sheep foot-rot (author's transl)]. 1979232438
calcium regulation in the myometrium of pregnant sheep.fractionation of pregnant sheep myometrium has been carried out and the fractions obtained analysed for their marker enzyme content and ca2+ transporting properties. a fairly pure mitochondrial fraction and a very pure plasma membrane fraction were obtained. both fractions could accumulate ca2+ in the presence of atp but the mechanisms were different, mitochondrial uptake had a high capacity and was inhibited by azide. plasma membrane uptake was of low capacity and unaffected by azide. the effec ...1979232478
voltage clamp and tracer flux data: effects of a restricted extra-cellular space. 1979232554
[chronic progressive interstitial pneumonia in sheep (adenovirus pneumonia)].adenoviral infection was established in imported specialized meat strains of sheep ile de france and romni marsh. the disease followed a course typical of chronic interstitial progressive pneumonia with reduced tonus, loss of body weight, and high lethality. the disease was serologically proven by the discovery of specific complement binding antibodies in dynamics against the adenovirus. titers varied from 1 : 2 to 1 : 32. the infestation was reproduced on sheep and lambs by tracheal infection w ...1979232587
[resistance of the aujeszky's disease virus to gamma ray irradiation].investigations on the resistance of aujeszky's disease virus to gamma irradiation from a 60co source were performed. the resistance of the virus was tested in vitro in a fluid medium of 50% henk's balanced saline solution, 50% eagle's medium mem and a supplement of 10% normal calf serum as well as its resistance on artificially virus infected pig skin and greasy wool of sheep. it is established that virus inactivation in the fluid medium occurs following 1.6 mrad gamma irradiation. the irradiate ...1979232589
permeability of plasma membrane vesicle to ouabain and mg2+ as a factor determining rate of binding of ouabain to na+ and k+ dependent atpase.na+, k+-atpase of the plasma membrane isolated from sheep kidney medulla exhibits functional asymmetry for the cardiac glycoside ouabain. in this vesicular membrane preparation the rate of binding of ouabain was slow (time constant greater than 60 min) when the vesicles were incubated in the presence of isotonic sucrose. upon treatment of the preparation with hypoosmotic shock or phospholipase a the initial rate of ouabain binding was enhanced at least 3 fold. in equilibrium a concentration of t ...1979232597
appearance of immunoglobulin g fc receptor in cultured human cells infected with varicella-zoster virus.after infection with varicella-zoster virus, hela and human embryo lung cells developed a receptor for the fc portion of human and rabbit immunoglobulin g. the receptor was detected by both hemadsorption and immunofluorescence, using antibody-coated erythrocytes and heat-aggregated immunoglobulin g. however, sheep erythrocytes sensitized with f(ab')2 of anti-sheep erythrocyte antibody did not adsorb to the receptor. when cell-free varicella-zoster virus was inoculated into the hela cell monolaye ...1979232695
modulation of t cells and macrophages by cholera toxin treatment in vivo and in vitro.cholera toxin influences the antibody response to srbc. enhanced responses occur in vivo and in vitro when ct is added together with antigen. however, ct depresses antibody formation when given in vivo before antigen but enhances in vitro responses under the same conditions. modulation of antibody formation appeared due to effects of t lymphocytes as well as macrophages. co-cultivation of immunologically impaired spleen cells from ct pretreated animals with macrophage-rich peritoneal cells or ed ...1979232818
[studies of necrotizing enteritis of suckling piglets (clostridium perfringens type c enterotoxemia) in industrialized sow breeding units. 4. epizootiology].necrotising enteritis had been the cause of death of 4.9 per cent in 5,177 nursed piglets, which was established by pathological examination. the number of piglets, in that context, which had come from industrialised sow breeding units was equivalent to 92 per cent. the nursed piglet held the third position, next to smaller ruminants (19.4 per cent) and fowl (6.0 per cent), with regard to the occurrence of clostridium perfringens enterotoxemia or necrotising enteritis in 112,218 animals which we ...1979232840
viral intestinal infections of animals and man. 1979232863
immune response to avian leukosis virus infection in chickens: sequential expression of serum immunoglobulins and viral antibodies. 1979232865
one-cycle growth studies with maedi-progressive pneumonia-visna viruses: shorter latent periods revealed. 1979232866
impaired immune function and identification of polybrominated biphenyls (pbb) in blood compartments of exposed michigan dairy farmers and chemical workers.in 1973 pbb's were accidentally mixed into animal feed, resulting in marked toxic effects. meat and dairy products were widely consumed in michigan. to determine the impact of pbb's, 55 exposed michigan farm residents, 11 michigan chemical workers and 46 non-exposed wisconsin farmers were examined. abnormalities included decreased number of t-lymphocytes with concomitant increase of lymphocytes with no detectable surface markers, "null cells", and altered lymphocyte function. data obtained from ...1979232874
[experiments to obtain and test a cell-culture rotavirus-precipitating antigen].the location of the rotaviral precipitating antigen and the possibility for its production from cattle rotaviral strains adapted on cell cultures of calf kidney were investigated. highest titer antigen was produced by concentration with ammonium sulfate simultaneously from the maintaining medium and from the cell monolayer. comparative studies on the antigenic and physico-chemical properties of the cell-cultural and the faeces rotaviral precipitating antigen were made. the identity of both antig ...1979232949
an ouabain-insensitive na-atpase of the arterial vascular muscle cell and its relation to ouabain-sensitive na,k-atpase.a na+-stimulated, mg++-requiring atpase (na-atpase), which is insensitive to ouabain, has been demonstrated in the carotis and coronary arteries of different species. in dependence on the sodium concentration half-maximal activities of na-atpase are found in the range from 16 to 24 mm na+. a replacement of mg++ by ca++ leads to a partial loss of activity. it does not, however, change its sensitivity to sodium. compared to na,k-atpase, the na-atpase shows a considerably lower sensitivity to calci ...1979232961
[effect of silica on the anti-tumour activity of "corynebacterium parvum" (author's transl)].silica, a specifically toxic substance for macrophages, has been used to study the role of these cells in the corynebacterium parvum-induced anti-tumour protection. in the two experimental tumours studied, silica, c. parvum and tumour cells were injected by the same route: the intravenous route in the case of lymphosarcoma in xvii mice and the intraperitoneal in that of mammary carcinoma in c3h mice. the inhibition of the anti-tumour effect of c. parvum by the administration of silica was more p ...1979232975
size of lipoproteins in intestinal lympho of sheep and suckling lambs.the relative importance of chylomicrons (sf greater than 400) and very low density lipoproteins (sf 20--400) in transporting lipids in lymph was investigated in surgically prepared adult sheep and pre-ruminant lambs fed low fat diets or infused intraduodenally with corn oil. the concentration of triacylglycerol in the intestinal lymph of sheep and lambs was increased from 520 and 925 mg/100 ml to 2326 and 2367 mg/100 ml respectively when corn oil was infused into the duodenum and the ratio of tr ...1979232980
effect of intravenously infused dexamethasone on collagen metabolism in skin of merino sheep.the effects of an 8-day intravenous infusion of dexamethasone (7.6 mg kg-0.75 body weight) on collagen biosynthesis and wool growth in skin were examined in four merino wethers. plasma dexamethasone concentrations reached their peaks during the first 24 h infusion, which were followed by relatively stable levels (c. 1 x 10(-7) m) for the next 4--5 days. minor increases in plasma dexamethasone levels were recorded during the final 2 days of treatment. dexamethasone concentrations quickly fell bel ...1979232981
the effects of levamisole on some functions of mouse macrophages after in vitro and in vivo administration.in vitro incubation of peritoneal macrophages from normal, peptone-stimulated mice with levamisole (1-100 microm) for 1 and 22 h had no effect on either phagocytosis of particulate material (sheep erythrocytes, zymosan) or cellular levels and release of lysosomal enzymes (beta-d-glucuronidase, cathepsin d). by contrast, levamisole 1 and 5 mm dramatically increased enzyme release while inhibiting phagocytosis. in some experiments, however, these high concentrations of levamisole caused an elevate ...1979233087
the pathogenesis of pig-bel in papua new guinea. 1979233175
the typing of cl. perfringens and the veterinary background. 1979233176
the occurrence of clostridium welchii type c in papua new guinea. 1979233178
the demonstration of maedi/visna virus in sheep in great britain.a virus indistinguishable from that causing maedi/visna has been isolated from a sheep flock in great britain. the virus was identified in cell cultures using immunofluorescent and electron microscopical techniques. the complement fixation test and the agar gel immunodiffusion test were used to assess the proportion of serological reactors within the flock. there has been no evidence of clinical disease in the flock into which foreign imports were introduced in the years prior to 1976.1979233278
[dna-protein interactions. destabilizing activity of sheep pancreatic rnaase].evidence is presented that ovine pancreatic ribonuclease, a protein strictly homologous to bovine rnaase a but with one positive charge less, has a definite 'destabilizing' activity (quite similar to that of the bovine enzyme) on double-stranded dna. this action of sheep pancreas rnaase has been measured by differential spectrophotometry and determining the thermal-transition profiles of the protein-dna complexes.1979233346
the current status of research on an experimental inactivated bluetongue virus vaccine. 1979233389
studies in epidemiology of maedi/visna in sheep.lambs born to ewes from flocks with a high incidence of maedi/visna were separated from their dams at birth (group 1), or after 10 h (group 2), six weeks (group 3) or one year (group 4) and were observed for periods of up to eight years. group 1 lambs remained free of infection while 28 per cent, 76 per cent and 81 per cent respectively of lambs in the other groups developed clinical, serological or histopathological evidence of infection during the observation period. it is therefore concluded ...1979233619
licorice raises urinary cortisol in man.the finding that urine cortisol excretion was increased in patients with hypokalaemic hypertension induced by licorice addiction led to this study on the effect of licorice in normal subjects. thirteen normal volunteers ate either 100 or 200 g licorice for 1-4 weeks and assessment of pituitary-adrenal function was made before, during, and 1 week after cessation of licorice ingestion. urine cortisol excretion more than doubled in 10 of 13 subjects (mean, 33.8 +/- 15.6 sd before and 83.3 +/- 56 sd ...1978233669
placental insufficiency, problems of etiology, diagnosis and management. 1975233751
a new freeze-dried living virus vaccine against sheep-pox.a sheep-pox virus strain has been adapted and multiplied in primary lamb kidney cell cultures. the main characteristics of the strain have been verified in vitro after clones were isolated, and the results confirmed its identity. the safety and the potency of the strain have been investigated in sheep. the inoculation of the strain to sheep was followed by a post-vaccinal reaction materialised by a nodule at the site of inoculation and an increase of temperature by about 1 degree c. no reactions ...1979233780
differential lipid control of (na+ + k+)-atpase in homeotherms and poikilotherms.1. (na+ + k+)-atpase from homeotherms and poikilotherms demonstrate non-linear thermal dependence for atp hydrolysis. apparent energies of activation from crab nerve preparations are less than those of brain or kidney preparations from beef, rabbit, sheep or ground squirrel. 2. crab nerve (na+ + k+)-atpase is less sensitive to inhibition by ouabain than that from beef or ground squirrel; lower rates of [3h]-ouabain binding and reduced amount of drug bound at equilibrium are found. 3. k+-activate ...1977233786
alterations in murine delayed type hypersensitivity responses by delta-8-thc and cannabinol.the ability of cannabinol and delta-8-tetrahydrocannabinol (delta-8-thc), two cannabinoid marihuana components, to modify delayed-type hypersensitivity (dth) to sheep red blood cells (srbc) was investigated in mice. reduction of dth reactivity by cannabinol required multiple, daily, postimmunization drug administration. neither multiple preimmunization dosings nor a single postimmunization dosing was effective. delta-8-thc produced moderate (13-33%) suppression of dth reactivity only upon multip ...1978233841
adenosine triphosphatase activity during fusion of cultured sheep choroid plexus cells induced by either visna virus or polyethylene glycol. 1978233847
experimental conditions for obtaining suppressor and helper effects on the primary in vitro immune response by lymphocytes activated by polyclonal t-cell activators.the effect of the polyclonal t-cell activators (pta) con a and pha on the specific immune response to sheep red blood cells (src) was studied. addition of pta either enhanced or suppressed the anti-src response, and two variables were found to affect the results: time of addition of the pta and the strength of the response in control cultures not given pta. if the response was high, even suboptimal pta concentrations induced suppressive effects, but if the control response was low, due to defici ...1977233907
cellular immunity in the mouse. iv. altered thymic-dependent lymphocyte reactivity in the chronic graft vs host reaction and leukemia virus activation. 1975233963
cellular immunity in the mouse. v. further studies on leukemia virus activation in allogeneic reactions of mice: stimulatory parameters. 1975233964
short communication. "sombrero" hemolytic plaques due to antibody of a single specificity against pneumococcal polysaccharide. 1975233965
enhancement of sheep red blood cell human lymphocyte rosette formation by the sulfhydryl compound 2-amino ethylisothiouronium bromide. 1975233982
renal response to vasopressin infusion in vitamin a-deficient and normal ewes. 1975234119
the phospholipase activity of sheep pancreatic juice.sheep pancreatic juice was found to contain at least two enzymes which hydrolysed biliary lecithin. one enzyme was heat and acid labile and hydrolysed the fatty acid from position 1 (phospholipase a1); the other was heat and acid stable hydrolysing the fatty acid at position 2 (phospholipase a2). lysophospholipase activity was also present. the phospholipases were active at ph values greater than 4.2, and would therefore function in the acid conditions (ph 3-6) of the sheep small intestine. the ...1975234191
physiocochemical properties of a lipoprotein antigen of echinococcus granulosus.molecular weight and optical properties of the lipoprotein b, the main antigen produced by the parasite in sheep hydatid fluid, have been determined. by sedimentation equilibrium studies, its molecular weight has been found equal to 120,000. circular dichroism and optical rotatory dispersion spectra are consistent with an alpha-helix content of about 50%, and this ordered structure is not completely destroyed by dissociation in guanidinium choloride. the ord spectrum is discussed in relation to ...1975234207
grain overload in cattle and sheep: changes in microbial populations in the cecum and rumen.samples from the rumen and cecum of cattle and sheep were cultured to determine changes in microbial populations resulting from overfeeding with grain. before the animals were overfed, the predominant organisms from both sides were those that grew anaerobically on a relatively nonselective ruminal fluid medium and would not grow on selective mediums designed to culture lactobacilli, streptococci, coliforms, or clostridium perfringens. by 24 hours after overfeeding, lactic acid bacteria had incre ...1975234213
effect of allogeneic cell interaction and graft-versus-host reaction on the antibody response to escherichia coli 0127 antigen. 1975234299
induction of primary and inhibition of secondary antibody response to hapten by hapten conjugates of type iii pneumococcal polysaccharide. 1975234300
temperature dependence of the actions of mammalian and reptilian gonadotropins in a lizard. 1975234320
effect of gold on the immune response of mice.separate concurrent injection of organic gold compounds and antigen into mice resulted in immunoenhancement that could be measured by direct and indirect plaque-forming cells, rosette-forming cells, and serum antibody assays. kinetics of the immune response showed variable effects through day 9 of the experiment. studies with british anti-lewisite, a gold antagonist, showed that the gold must stay in the system 1 day to obtain immunoenhancement.1975234408
complement activation by interaction of polyanions and polycations. i. heparin-protamine induced consumption of complement.interactions of heparin and protamine in fresh human serum, in amounts far below those required for complement depletion by either agent alone, were found to induce virtually complete depletion of total hemolytic complement activity. this depletion was dependent on time, temperature, ph, divalent cations, and serum concentration. the predominant complement component hemolytic activity depleted was c1; under appropriate reaction conditions c4 and c2 were depleted as well. equivalent amounts of he ...1975234494
physiological studies on the pneumococcal forssman antigen: a choline-containing lipoteichoic acid.the cell concentration and possible biological activities of the pneumococcal forssman (f) antigen (membrane lipoteichoic acid) were examined in a number of physiological situations. in test tube cultures of pneumococci the concentration of the forssman antigen per bacterium showed no significant fluctuations within a typical culture cycle. purified f antigen had no effect on the activation of pneumococci to competence for genetic transformation, dna mediated genetic transformation or adsorption ...1975234510
interaction of sindbis virus with liposomal model membranes.radiolabeled sindbis virus was found to bind to protein-free lipid model membranes (liposomes) derived from extracts of sheep erythrocytes. the virus interaction was dependent on initial ph, and the range of ph dependence (ph 6.0 to 6.8) was the same as the observed with virus-dependent hemagglutination. after the initial interaction, ph changes no longer influenced the virus binding to liposomes. virus bound to liposomes prepared from a mixture of erythrocyte phospholipids, but the binding was ...1975234538
lung vascular smooth muscle as a determinant of pulmonary hypertension at high altitude.the pulmonary hypertensive response to chronic hypoxia varies markedly among mammalian species. an explanation for this variability was sought by exposing seven species to hypobaric hypoxia (pb equal to 435 mmhg) for 19-48 days. control animals were studied at 1,600 m (pb equal to 630 mmhg). the pulmonary hypertension that developed varied in the following order of decreasing severity: calf and pig (severe); rat and rabbit (moderate); sheep, guinea pig, and dog (mild). right ventricular hypertro ...1975234690
solubility and net exchange of calcium, magnesium and phosphorus in digesta flowing along the gut of the sheep.1. the changes in the solubility of calcium, magnesium and phosphorus in digesta flowing along the intestinal tract and the net movement across the intestinal wall of these elements were determined in six rams, each equipped with three t-shaped cannulas; cannulas were placed in a total of six different sites of the small intestine. cr2o3 was used as a marker substance to measure the rate of flow of the digesta. 2. the concentrations of soluble ca, mg and p decreased as digesta moved along the in ...1975234736
peripheral blood lymphocyte subpopulations in sarcoidosis. 1975234800
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