| studies on bovine leukaemia. iii. the haematological and serological response of sheep and goats to infection with whole blood from leukaemic cattle. | | 1976 | 186987 |
| cardiovascular actions of prostaglandins d and e in the sheep: evidence for two distinct receptors. | | 1976 | 187037 |
| some properties of a prostaglandin f2alpha receptor in corpora lutea. | | 1976 | 187038 |
| adrenocortical-related maturational events in the fetus. | in various organs in fetal animals, maturation is inducible by corticosteroids and delayed by hypophysectomy. a surge of corticosteroid in the fetal circulation preceding parturition may cause rapid organ maturation and enhanced viability. since this phase of accelerated maturation is linked to the parturitional mechanisms, the changes can be termed collectively "preparation for birth." support for similar adrenocortical-related maturation of organs in the human fetus is less clear-cut. neverthe ... | 1976 | 187057 |
| isolation and characterization of a virus associated with progressive pneumonia (maedi) of sheep. | a virus with growth and morphologic characteristics of progressive pneumonia (maedi-visna) virus was isolated from the lungs of sheep with typical clinical and postmortem changes of chronic progressive pneumonia. the virus grew slowly in cultures of embryonic ovine lung cells, causing syncytial formation and degeneration. syncytia developed much slower and involved fewer cells than reported for other similar viruses isolated from sheep. as seen with the electron microscope, the virus reproduced ... | 1976 | 187087 |
| [diagnosis and differential diagnosis of rinderpest]. | starting from the clinical symptoms and the pathological-anatomical changes hints are given on the diagnosis of the rinderpest and how to distinguish it from other diseases. the paper discusses the differential diagnosis of the rinderpest with respect to mucosal disease, malignent catarrhal fever, nairobi sheep disease, salmonellosis, pasteurellosis, and coccidiosis. | 1976 | 187165 |
| copper and the oxidation of hemoglobin: a comparison of horse and human hemoglobins. | oxidation studies of hemoglobin by cu(ii) indicate that for horse hemoglobin, up to a cu(ii)/heme molar ratio of 0.5, all of the cu(ii) added is used to rapidly oxidize the heme. on the other hand, most of the cu(ii) added to human hemoglobin at low cu(ii)/heme molar ratios is unable to oxidize the heme. only at cu(ii)/heme molar ratios greater than 0.5 does the amount of oxidation per added cu(ii) approach that of horse hemoglobin. at the same time, binding studies indicate that human hemoglobi ... | 1976 | 187214 |
| a comparison of some serological tests for bluetongue virus infection. | the plaque neutralization, complement fixation, and agar gel precipitin tests were compared by measuring bluetongue virus antibody in 137 serums from experimental animals (cattle and sheep) and suspected field reactors (cattle and deer). in general, the tests agreed well with each other. plaque neutralization titers began earlier than the other two and went much higher than the complement fixation titers. plaque neutralization titers usually peaked between two and three weeks after exposure and ... | 1976 | 187301 |
| interaction of human growth hormone with isolated rat liver cells. | the interaction of 125i-labeled human growth hormone (hgh) with isolated rat liver cells is a specific, time dependent and saturable process. in male rats, one cell binds a maximum of 2000 hormone molecules; the dissociation constant of the cell-hgh interaction is about 3 x 10(-10)m. liver cells of female rats bind 5 to 10 times more hgh than do those of male rats at equivalent hormone concentrations. binding of 125i-labeled hgh to liver cells is readily inhibited by native hgh; 50% inhibition o ... | 1977 | 187405 |
| inhibition of the hemolytic activity of quartz by a chemically modified lysozyme. | | 1976 | 187425 |
| production and standardization of polyvalent clostridium perfringens vaccine in iran. | in this presentation an account of the large-scale production and the standardization of polyvalent clostridium perfringens vaccine in iran is described. over 20 million doses of this vaccine are produced and utilized in iran every year. certain modifications have been made to the culture media used in our laboratory for the production of this vaccine in order to bring down its cost. the prepared vaccine is highly immunogenic as determined by the laboratory examination on the quality of the vacc ... | 1976 | 187509 |
| the standardization of cl. perfringens antigens and antisera. | the preparation of laboratory standard antitoxins against cl. perfringens beta and epsilon toxins is described. these antitoxins are suitable for the quantitative determination of the corresponding antigens by means of the flocculation test. the flocculation test was, however, shown to be more suitable for determining the antigenic value of fresh toxoid rather than toxoid stored without neutralization of excess formalin. a maximal immunity response to alum-precipitated epsilon toxoid was obtaine ... | 1976 | 187510 |
| [comparison between the official indirect method and the direct method of control of vaccines against sheep enterotoxemia]. | the official methods of control of vaccines against sheep enterotoxemia are indirect in two ways : on the one hand they are carried out on animals for which the vaccine is not intended, and on the other hand they test only an immunological serum reaction. another method consisting of direct testing by intravenous injection of toxin has been carried out on mice previously vaccinated with different doses. it has been shown that it is possible to obtain a certain level of protection giving a good d ... | 1976 | 187512 |
| solid-phase radioimmunoassays for quantitative antibody determination of bacterial exotoxins. measurement of clostridium perfringens type d epsilon antitoxin. | two reversed solid-phase radioimmunoassays have been developed for quantitative determination of antibodies against clostridium perfringens type d epsilon toxin. 125i labelled prototoxin was used in the bromoacetyl cellulose-bound antibody method and in the antibody coated tube method. the procedures are based on the competition for 125i labelled prototoxin between the insoluble antibodies and the antibodies present in the unknown sample. the radioactivity bound to solid-phase is in inverse rati ... | 1976 | 187514 |
| the pathogenesis of fever: neurochemical aspects. | | 1976 | 187561 |
| effect of pasteurization and heat treatment on bovine leukemia virus. | four sheep inoculated with mixtures of bovine leukemia virus (blv) and milk that was treated by a simulated high-temperature short-time pasteurization procedure did not become infected with blv or develop tumor. four sheep inoculated with unpasteurized blv-mil mixtures became infected with blv and 3 died with tumor at 15, 21, and 27 months, respectively, after inoculation. fluid from a blv-infected cell culture was heated to 56, 60, 65, and 73 c for 1/2 minute and 1 minute (in separate trials) a ... | 1976 | 187564 |
| the effect of colostrum-derived antibody on louping-ill virus infection in lambs. | the influence of colostrum-derived antibody to louping-ill virus on the course of experimental infection was investigated in lambs. lambs that had high titres of antibody were refractory to infection. lambs that had low titres of antibody did not develop a viraemia but either showed an antibody reaction or were sensitized as judged by the immune response, which was typical of an anamnestic response, after rechallenge. animals that had no antibody 34-20 days before challenge had either no or very ... | 1976 | 187692 |
| cell membrane antigen isolation with the staphylococcal protein a-antibody adsorbent. | procedures are detailed for the rapid isolation of representative cell membrane antigens with protein a-bearing staphylococci as an adsorbent for igg antibodies complexed with the antigens. cell surface membrane proteins were radioiodinated and solubilized in nonionic detergent. specific antisera were subsequently added and the immune complexes precipitated by addition of the staphylococcal adsorbent and low speed centrifugation. the antigens isolated included surface immunoglobulins from mouse ... | 1976 | 187693 |
| slow persistent infection caused by visna virus: role of host restriction. | proviral dna has been demonstrated by in situ hybridization in foci of cells of a lamb infected with the rna slow virus visna. a few of these cells also contain the major virion structural antigen p30. this restriction in virus gene expression in the infected animal provides a mechanism for persistence of virus in this chronic infection. | 1977 | 188133 |
| further immunological evidence for the presence of fc receptors on the surface of hsv-infected cells. | by coupling passive hemadsorption (phads) reaction with a complement-mediated cytotoxicity test (ct) it is possible to detect the presence on the surface of hamster embryo fibroblasts of forssman antigens, hindering the demonstration by phads of the receptors for the fc-fragment of immunoglobulins (fcr), possibly induced by herpes simplex virus (hsv). these antigens are acetone- and formol-resistant, but they are destroyed by treatment with methanol or ethanol. however, ct with anti-sheep rbc se ... | 1976 | 188233 |
| gustatory-alimentary reflex inhibition of aldosterone hypersecretion by the autotransplanted adrenal gland of sodium deficient sheep. | | 1977 | 188283 |
| uptake of macromolecules by the thyroid. | | 1977 | 188285 |
| [epidemiologic significance of permanent foot-and-mouth disease virus excretors]. | | 1977 | 188407 |
| differences between murine c1300 neuroblastoma clones detected by rosette formation with nerve growth factor-coated sheep red blood cells. | the expression of receptors for nerve growth factor (ngf) on the cell surface was assayed by rosette formation with ligand-coated sheep red blood cells (srbc). cell clones derived from the murine c1300 neuroblastoma and from hybrids between a neuroblastoma clone and l cell clones showed a wide variation in the capacity to form rosettes with ngf-coated srbc. all the neuroblastoma, l cell and hybrid clones formed rosettes with phytohemagglutinin-coated srbc and none formed rosettes with cytochrome ... | 1976 | 188519 |
| isolation of bluetongue vaccine virus from infected sheep by direct inoculation onto tissue culture. | a technique is described by which the vaccine strain of bluetongue virus (btvv) may be isolated from infected fetal, neonatal, and adult sheep tissues utilizing tissue culture. the data from these studies provides evidence that 1) btvv can be readily isolated from infected fetal and newborn tissues by tissue culture, 2) mild treatment of tissues and utilization of lysed cells as inoculum an effective means of recovering vaccine virus, 3) btvv can be isolated with equal efficacy from mononuclear ... | 1977 | 188594 |
| induction of binding of sheep red blood cells with the surface of mouse thymocytes by means of phytohaemagglutinin and concanavalin a. | | 1977 | 188682 |
| effect of thyroxine on the in vitro formation of erythropoietin in kidney medulla slices. | | 1976 | 188754 |
| corticotroph cells in primary cultures of rat adenohypophysis: a light and electron microscopic immunocytochemical study. | monolayer cultures of trypsin-dispersed cells of the rat adenohypophysis were grown for 5 to 54 days. acth was localized by immunocytochemistry using an antiserum to synthetic acth1-28 prepared in rabbit and sheep anti-goat immunoglobulin coupled with peroxidase. acth content of the culture medium was measured by radioimmunoassay. corttion time. the corticotrophs retained their essential morphological characteristics. immunological staining was found in the secretory granules, some tubular or sa ... | 1976 | 188791 |
| effects of beta subunit acylation on lutropin receptor site binding. | the effects of various modifications on the beta subunit of lutropin have been studied using the binding characteristics of the reconstituted hormone in the rat testicular radioligand assay. conditions for iodinating lutropin and lutropin derivatives were determined which resulted in 15 per cent specific binding when tested immediately and retention of 6 to 7 per cent specific binding even after storage for 6 months. acetimidinyl, acetyl, and carbamyl derivatives of the beta subunit were prepare ... | 1977 | 188817 |
| thymus-like activities of sulphur derivatives on t-cell differentiation. | levamisole and sodium diethyldithiocarbamate can induce in vivo thymocyte differentiation from precursor spleen cells of nu/nu mice and evoke indirect plaque-forming cells in nude mice immunized with sheep red cells. these sulphur drugs induce in thymusless mice the production of a serum factor which transfer in vivo immune enhancement and in vitro thymocyte differentiation. in vivo treatment with sulphur derivative can substitute for an alleged thymice hormone. | 1977 | 188971 |
| chemistry of the lipotropins. | | 1976 | 189337 |
| rhythmic phenomena in prenatal life. | | 1976 | 189352 |
| [djalonke sheep of the ivory coast in a village environment. behavior and feeding]. | | 1976 | 189362 |
| [hodgkin's disease: study of delayed hypersensitivity of 64 non treated patients. value of epicutaneous test using croton oil]. | cellular immunity in 64 patients with hodgkin's disease was studied during diagnosis before any treatment. the functional deficiency of the thymodependent lymphocyte was demonstrated in vivo by skin tests and, in vitro, by the test of inhibition of leucocyte migration to phytohemagglutininin and spontaneous rosette formation, to sheep red cells. this deficiency correlates with the clinical spread and the histological severity. the relationship between skin anergy and biological tests was found. ... | 1977 | 189435 |
| parasitic nematode larvae as agents of transmission of pathogenic bacteria. | | 1976 | 189513 |
| circulatory response to systemic infusion of norepinephrine in the pregnant ewe. | seven pregnant ewes from 100 to 137 days of gestation were infused with systemic doses of norepinephrine and uterine arterial flow dose-response curves were determined. a constant infusion of norepinephrine at a mean rate of 0.24 mug per minute per kilogram led to a 39.3 per cent decrease in total uterine arterial blood flow as measured with isotope-labeled microspheres while systemic pressure was unaltered. at this dose the reduction in endometrial blood flow (--64 per cent) was significantly g ... | 1977 | 189612 |
| studies on rat ovarian receptors for lutropin (luteinizing hormone). interaction with beta-subunit of sheep lutropin. | by using radioimmunoassay, the interaction of sheep lutropin (luteinizing hormone, lh) beta-subunit with rat ovarian receptors was investigated. the binding of beta-subunit was specific, although of much lower order than that of lutropin. sheep lutropin beta-subunit effectively inhibited the binding of human choriogonadotropin (chorionic gonadotropin, gcg) to the ovary, showing that both occupy the same sites. the binding of sheep lutropin beta-subunit to ovary was not followed by any detectable ... | 1976 | 189756 |
| [effect of adrenaline on the smooth muscle of the sheep stomach]. | | 1976 | 190051 |
| comparative studies of the alpha and beta adrenergic receptors in the longitudinal and circular smooth muscle layers of the simple and complex stomach. | | 1976 | 190082 |
| selective ability of entomoeba histolytica to haemolyse red blood cells--a preliminary communication. | | 1976 | 190167 |
| antigen induced alterations in splenic prostaglandin and cyclic nucleotide levels in nzb mice. | studies were undertaken in order to determine if nzb mice injected with sheep erythrocyte antigens would respond by showing elevated splenic prostaglandin and cyclic nucleotide levels similar to that observed in normal mice. the results show that young nzb mice can respond to sheep erythrocytes by yielding increased levels of splenic pgf2alpha and camp. however, because of increased basal levels of pgf2alpha and camp, the net increase observed is lower than that observed with normal mice. in old ... | 1977 | 190314 |
| the mononuclear cell in human blood which mediates antibody-dependent cellular cytotoxicity to virus-infected target cells. i. identification of the population of effector cells. | mononuclear cells (mc) from human blood were fractionated by a variety of physical and immunologic techniques, and the cellular subpopulations generated were assessed for their capacity to lyse herpes simplex virus (hsv)-infected target cells in the presence of igg antibody to hsv. latex phagocytosis and surface marker studies were performed in parallel in order to identify the major effector cells by their phagocytic properties and their possession of surface immunoglobulin and receptors for ei ... | 1977 | 190316 |
| in vivo suppression of the primary immune response by a species of low density serum lipoprotein. | an apparent subspecies of normal human serum low density lipoprotein (ldl-in) has been identified with suppressive activity for early or facilitating events of human lymphocyte mitogen and allogenic cells stimulation in vitro. this report describes the effects of in vivo administration of ldl-in on the mouse anti-srbc immune response. human ldl-in is not species specific and was capable of suppressing the in vivo mouse anti-sheep erythrocyte (srbc) hemagglutination response by 88% after the admi ... | 1977 | 190318 |
| immunosuppression in mice after inoculation with 334c, a murine lymphatic leukemia-inducing virus. | 334c murine leukemia virus, which induces a high incidence of lymphatic leukemias (80-90%) in susceptible mice following a long latency period, was found to cause a severe in vivo suppression of direct plaque-forming cells from the spleen, following antigenic stimulation with sheep red blood cells. neonatally infected inbred balb/c and outbred ha/icr swiss mice, which develop a sustained viremia, were highly susceptible to the immunosuppressive effect of this virus as early as 1 week after virus ... | 1977 | 190412 |
| transmission of two strains of epizootic hemorrhagic disease virus in deer by culicoides variipennis. | two strains of epizootic hemorrhagic disease virus (ehdv), new jersey (nj) and kentucky (ky), of deer were biologically transmitted between white-tailed deer, odocoileus virginianus, by culicoides variipennis. the ky strain, isolated from c. variipennis collected during an epizootic in deer, was identified as ehdv by serological tests. deer exposed to the ky or the nj strains of ehdv developed an acute hemorrhagic disease; most deer died 6 to 13 days after infection. sheep inoculated with ehdv d ... | 1977 | 190424 |
| the effect of labour on uterine blood flow in the pregnant ewe. | the effect of labour on cardiac output and uterine blood flow was measured in pregnant ewes at a mean gestation of 124 days using radioactive microspheres labelled with 169yb and 85sr. labour was induced by a continuous infusion of acth into the foetal circulation. cardiac ouput measured before acth infusion in seven ewes was 5234 +/- 175-9 ml./min (mean +/- s.e.) and total uterine blood flow was 732 +/- 57-9 ml./min (mean +/- s.e.). measurements during labour in six ewes showed a significant in ... | 1976 | 190630 |
| effects of starvation, surgery and infusion of adrenocorticotrophin on plasma amino acid concentration in the pregnant ewe. | total plasma amino acid concentrations (taa) in 12 scottish blackface ewes between 80 and 140 days of pregnancy were unaltered by two days of starvation, but concentrations of essential amino acids (eaa) increased and non-essential amino acid (naa) levels decreased. these trends were more pronounced later in pregnancy. ewes fasted before surgery to implant fetal catheters showed marked reductions in mean taa levels (--26 per cent, n-5) on the day after operation (day+ 1). half of this decrease w ... | 1977 | 190661 |
| immunological cross-reactions of the major internal protein component from "slow" viruses of sheep. | | 1977 | 190776 |
| pulmonary carcinoma (jaagsiekte) of sheep. ultrastructural study of early and advanced tumor lesions. | lung carcinoma of sheep (jaagsiekte) is a bronchiolar-alveolar cell carcinoma. differences in the ultrastructural patterns of early and advanced lesions of the disease are described. a-type and c-type viruses were observed in advanced tumors and were absent in early lesions. numerous microtubules were characteristic in the epithelial tumor cells of the early lesions and were absent in the advanced tumor. in comparison to the early lesions, extensive cytosome production, surfactant secretion, and ... | 1977 | 190891 |
| complement-induced decrease in membrane mobility: introducing a more sensitive index of spin-label motion. | we have used spin-labeling to investigate complement-induced changes in lipid organization of antibody-sensitized sheep erythrocyte membranes. the spectrum of methyl 5-doxylstearate incorporated into the lipid component of sheep erythrocyte membranes is typical of a membrane bilayer. the membranes from complement-lysed erythrocytes have a small, but statistically significant, reduction in fluidity when compared to membranes from osmotically-lysed erythrocytes, as indicated by a small increase in ... | 1977 | 191062 |
| antibody like activities against cholesterol ester in anti-ldl antiserum. an observation on the surface of ldl. | the antibody like activities against cholesterol and cholesterol ester were examined by means of radioimmunoassay system, immunolysis of liposomes containing cholesterol and other steroids. in comparison with anti-etiocholenic acid antiserum and anti-cholesterol succinate antiserum, it was proved that anti-ldl antiserum contained 2 kinds of antibodies, one was specific to the structure of cholesterol skeleton and other was specific to the whole structure of cholesterol ester. ldl only combined w ... | 1976 | 191116 |
| comparison of antiviral and antitumor activity of activated macrophages. | | 1977 | 191199 |
| [demonstration of a cytosol protein binding cholesterol in the adrenal glands]. | characterization of a cytosolic protein of adrenal origin that binds cholesterol. adrenal cytosol contains a thermostable protein which binds cholesterol specifically and non-covalently. the sedimentation coefficient of the complex is close to 3 s. the side chain of the cholesterol molecule is responsible for the binding specificity. | 1977 | 191211 |
| dihydropteridine reductase from bovine liver. purification, crystallization, and isolation of a binary complex with nadh. | dihydropteridine reductase [ec 1.6.99.7] was purified from bovine liver in 50% yield and crystallized. the physicochemical properties of the purified enzyme were quite similar to those of sheep liver dihydropteridine reductase. during the course of purification, however, the enzyme was found to be separated into 2 major peaks together with minor peaks by column chromatography on cm-sephadex, and one of the major peaks was identified as a binary complex of the enzyme with nadh. the reductase-nadh ... | 1977 | 191436 |
| a radioimmunoassay for 3,3',5'-l-triiodothyronine (reverse t3): assessment of thyroid gland content and serum measurements in conditions of normal and altered thyroidal economy and following administration of thyrotropin releasing hormone (trh) and thyrotropin (tsh). | the present report describes the development of a radioimmunoassay for 3,3',5'-l-triiodothyronine (reverse t3) which is performed on unextracted serum. utilizing this radioimmunoassay, 21 normal subjects had a mean (+/-sd) serum reverse t3 level of 60 +/- 12 ng/100 ml, 17 of 19 hyperthyroid patients had elevated serum reverse t3 levels, and 10 of 11 hypothyroid subjects had decreased serum reverse t3 concentrations. thyroidal secretion of reverse t3 was assessed by measurements in samples obtain ... | 1977 | 191466 |
| corticosteroid inhibition of adrenocorticotrophin secretion in the foetal sheep. | | 1977 | 191560 |
| study on the pathogenesis of bluetongue: replication of the virus in the organs of infected sheep. | the pathogenesis of bluetongue infection was studied by the titration of the virus in tissue samples taken from sheep inoculated subcutaneously in the auricula of the ear with 76 tc id50 of the plaque-purified type 10 bluetongue virus. tissue samples were taken from individual animals killed at daily intervals over a period of 11 days. the mean incubation time was 6.9 days and the first clinical sign was pyrexia. on the 4th day, bluetongue virus was demonstrated in the lymph nodes of the cephali ... | 1976 | 191775 |
| kinetics of the igm and igg immunological response to sheep erythrocytes and bluetongue virus in mice. | the igm and igg response of mice to sheep erythrocytes (srbc) and bluetongue virus (btv) was determined by means of haemolytic plaque assays. maximum primary igm response to srbc occurred after 4 days but declined rapidly to 4% of the maximum by day 9. a lag period of about 2 days was observed in the appearance of igg haemolytic plaque-forming cells (pfc) but they reached a maximum after 6-9 days. secondary immunization resulted in the stimulation particularly of igg pfc and from day 6 onwards i ... | 1976 | 191776 |
| stoichiometry of gtp hydrolysis and tubulin polymerization. | microtubule formation from lamb brain tubulin isolated by affinity chromatography and freed of exchangeable nucleotide requires gtp for maximal rate and extent of polymerization. the nucleotide analogs guanylylmethylenediphosphate and guanylylimidodiphosphate fail to replace gtp; in addition, neither the presence of microtubule associated proteins nor 5 m glycerol relieves the gtp requirement. the relation of gtp concentration and microtubule formation shows an association constant k = 1 x 10(4) ... | 1977 | 191810 |
| host-determined differences in expression of surface marker characteristics on human and simian lymphoblastoid cell lines transformed by epstein-barr virus. | in an attempt to account for differences in the biologic behavior of epstein-barr virus in different primate species, we studied lymphocyte surface markers on primary and transformed cells. among primary leukocytes, the distribution of cells with characteristics of bone-marrow-derived cells (b cells) was similar in humans, wooly monkeys, and cotton-top marmosets. however, after transformation by epstein-barr virus, cells from each species were characterically different. transformed human umbilic ... | 1977 | 191824 |
| [ovine enterotoxemia caused by cl. perfringens type a]. | | 1976 | 191981 |
| [experience in treating sheep with clostridial infections]. | | 1976 | 191982 |
| [localization and specificity of k+-p-nitrophenylphosphatase activity in sheep primitive kidney]. | | 1976 | 192010 |
| the ultrastructure of early visna lesions. | the ultrastructure of visna, a slowly progressive menigo-encephalomyelitis of sheep, was studied in animals sacrificed one month after intracerebral inoculation of visna virus. the major pathological changes, representative of those seen during the first year after infection, consist of inflammation and minor focal destructive lesions of grey and white matter. the inflammatory infiltrates, both subependymal and perivascular as well as of the choroid plexus, were composed mainly of lymphocytes an ... | 1977 | 192037 |
| experimental visna in icelandic lambs. | | 1977 | 192064 |
| chronic lymphoproliferative disorder with unusual clinical, morphologic, ultrastructural and membrane surface marker characteristics. | four of 105 patients with chronic lymphocytic leukemia (cll) manifested clinical, morphologic, ultrastructural and membrane surface marker characteristics that differed from those found in patients with typical cll of demonstrated b-lymphocyte origin. these four patients presented with moderate increases in absolute lymphocyte counts, absolute neutropenia, polyclonal hypergammaglobulinemia and hepatosplenomegaly without lymphadenopathy. two of them were unusually young, 19 and 25 years old, at t ... | 1977 | 192076 |
| studies on the epidemiology of sandfly fever in iran. ii. the prevalence of human and animal infection with five phlebotomus fever virus serotypes in isfahan province. | human and animal sera from an endemic area of sandfly fever in iran were tested by plaque reduction neutralization method against five different phlebotomus fever virus serotypes (naples, sicilian, karimabad, salehabad, and i-47). the overall prevalence of naples, sicilian, and karimabad virus antibodies among the human population was 17%, 25%, and 66%, respectively. all sera were negative against salehabad and i-47 viruses. age-specific antibody rates suggested that sicilian and karimabad virus ... | 1977 | 192093 |
| overwintering mechanism for bluetongue virus: biological recovery of latent virus from a bovine by bites of culicoides variipennis. | bluetongue virus (btv) was biologically transmitted by the bites of colonized culicoides variipennis gnats to recipient sheep from a hereford bull with latent infection. four biological recoveries of btv were mediated over 2 years by multiple feedings of the vector during a 4- to 72-hour interval. initial stimulation by gnat bites at 0 hour permitted biological recovery of btv by gnats that fed at later intervals. the 4th biological recovery of the virus from the bull clearly indicated a vector- ... | 1977 | 192095 |
| the effect of fasting on blood constituents in domestic animals. | | 1976 | 192121 |
| induction of parturition in farm animals. | | 1976 | 192122 |
| [immunoglobulins and sheep red cell receptors in human lymphoblastoid cell lines simultaneously carrying epstein-barr virus and cytomegalovirus genomes]. | in this communication we attempt to characterize the principal immunological properties of 3 human lymphoblastoid cell lines (lcl) established in our laboratory which carry both the ebv and cmv genomes. the data obtained suggests that two lcl are representative of b lymphocytes while the other lcl has a mixed cell population with the majority being of the b type. the reasons for this heterogeneity are discussed. it is suggested that cmv may also transform thymus-independent (b) lymphocytes. | 1977 | 192131 |
| studies of the influence of cyclic nucleotides on in vitro haemoglobin synthesis. | the influence of various cyclic nucleotides on in vitro haemoglobin synthesis has been examined in suspension cultures of mammalian marrow cells. over a wide range of concentrations, dibutyryl cyclic amp (db-camp) was either ineffective or inhibited haemoglobin synthesis by marrow cells from rat, mouse and guinea-pig. however, 10(-3) m db-camp consistently stimulated haemoglobin synthesis in cultures of human, sheep, rabbit and canine cells, with the latter being most responsive. this effect, wh ... | 1977 | 192263 |
| function of lysosomes during luteal regression in normally cycling and pgf alpha-treated ewes. | | 1977 | 192354 |
| further unravelling of the causes of acth-induced hypertension in the sheep. | 1. acute severe sodium subtraction (20-25% of total exchangeable sodium) before or during treatment with adrenocorticotrophic hormone (acth) does little to modify the increase in blood pressure induced by acth. 2. chronic low salt diet, less than 5 mmol/day, abolishes the blood pressure increase, but the response can be restored by increasing the sodium intake to as little as 10 mmol/day. 3. 17alpha,20alpha-dihydroxyprogesterone infused concurrently with other adrenal steroids will mimic acth hy ... | 1976 | 192514 |
| studies of the binding activity to different gonadal receptors of ovine luteinizing hormone (lh) after chemical modification of lysine residues. | | 1977 | 192631 |
| morphologic aspects of nuclear bodies in a case of bronchiolar-alveolar carcinoma of the lung. | the ultrastructural features of a bronchiolar-alveolar carcinoma of the lung are described wherein the presence of nuclear bodies in many of the tumor cells were noted. although these bodies are not viral elements, it is surmised that they may be virus associated and consequently possibly related to the etiology of this tumor. a review of the ultrastructural findings in the pulmonary adenomatosis of sheep is presented, and these are compared with those in human disease. experimental evidence of ... | 1977 | 192658 |
| isolation and characterization of the urothelial lumenal plasma membrane. | the lumenal plasma membrane has been isolated from transitional epithelial cells (urothelium) lining the urinary bladder in sheep by a modified technique involving treatment with hypotonic thioglycolate. the isolated membranes, like those in situ, are distinguished morphologically by arrays of hexagonal particles (in plague regions) separated by smooth interplaque regions. these plaque regions, specifically, can be isolated from the lumenal plasma membrane. of the proteins constituting the lumen ... | 1977 | 192735 |
| reactivity of non-primate growth hormones and prolactins with human growth hormone receptors on cultured human lymphocytes. | ovine placental lactogen is as reactive as human growth hormone with the human growth hormone receptor of cultured human (im-9) lymphocytes, which confirms the findings of carr and friesen with receptors of human liver. we now also show that bovine and ovine growth hormones and ovine prolactin have reactivity for the human growth hormone receptor on im-9 lymphocytes that is of the same order of magnitude (0.03%) as that previously reported for human placental lactogen. the binding studies predic ... | 1977 | 192753 |
| effect of concanavalin a on the killing of tumor cells by antibody and complement. | concanavalin a (con a) was found to inhibit the killing of antibody-sensitized line-1 tumor cells (ta) by guinea pig complement (gpc) but not by human complement (huc). other plant lectins (wheat germ, leucoagglutinin, and pokeweed mitogen) were also tested but con a was the only lectin found to inhibit antibody-gpc-mediated killing. the inhibitory effect of con a was observed when the gpc was mixed with con a or when the antibody-sensitized cells were pretreated with con a (ta-con a) before the ... | 1977 | 192797 |
| slow virus infection: replication and mechanisms of persistence of visna virus in sheep. | the influence of the age and immune status of the host on the slow replication and persistence of visna virus in sheep was studied. twenty-five randomly bred fetal american lambs were inoculated intracerebrally with visna virus. eight of these fetuses were immunosuppressed by thymectomy and antiserum to lymphocytes before inoculation. fetuses were sacrificed sequentially, and tissues were processed for viral quantitation. no exponential increase of virus occurred in either the normal or immunosu ... | 1977 | 192812 |
| some experiments on the role of the foetal pituitary in the maturation of the foetal adrenal and the induction of parturition in sheep. | the effect of repeated increases in plasma acth on the production of corticosteroids and androstenedione in the sheep foetus has been investigated. elevation of foetal plasma acth for up to 2 h every 24 h by repeated periods of hypoxia increased the output of cortisol. no consistent effects on foetal or maternal androstenedione concentrations or on maternal oestrogen levels were observed. repeated short periods of increased foetal plasma acth concentration may promote maturation of the foetal ad ... | 1977 | 192819 |
| developmental changes in the responses of the adrenal glands of foetal sheep to endogenous adrenocorticotrophin, as indicated by hormone responses to hypoxaemia. | the change in plasma acth and corticosteroid concentrations in response to a 60 min period of hypoxaemia were studied in foetal and adult sheep during the latter half of pregnancy. hypoxaemia consistently caused large rises in the concentration of acth in foetal plasma, the magnitude of which did not change with gestational age but was related to the physiological state of the foetus. before 139 days small and slow rises in corticosteroid (predominantly cortisol) concentration in foetal plasma w ... | 1977 | 192820 |
| changes in the concentration of adrenocorticotrophin and corticosteroid in the plasma of foetal sheep in the latter half of pregnancy and during labour. | the changes in plasma acth concentration of pregnant sheep and their foetuses during the latter half of pregnancy and during labour were studied. before 140 days of gestation the mean concentration in foetal arterial plasma was 117+/-19 (s.e.m.) pg/ml which rose to a mean of 286+/-63 pg/ml. the rise in acth occurred at about the same time as, but not before, the rise in corticosteroid concentration in foetal plasma. the maternal plasma acth concentration did not change during the latter half of ... | 1977 | 192821 |
| control of adrenocorticotrophin secretion by catecholamines in the pregnant and foetal sheep. | the effect of adrenaline on the maternal and foetal plasma acth concentration of twelve pregnant sheep with chronically implanted vascular catheters has been studied. adrenaline infused into the jugular vein of the ewe or foetus produced carotid arterial adrenaline concentrations of 1-9 ng/ml. the foetal plasma acth was 253 +/- 73 pg/ml and it showed a fivefold increase during adrenaline infusion; the acth concentration achieved was proportional to the plasma adrenaline. in the ewe plasma acth w ... | 1977 | 192822 |
| lymphoma in cotton-top marmosets after inoculation with epstein-barr virus: tumor incidence, histologic spectrum antibody responses, demonstration of viral dna, and characterization of viruses. | 6 of 20 cotton-top tamarins (saguinus oedipus) inoculated with epstein-barr virus (ebv) developed diffuse malignant lymphoma resembling reticulum cell or immunoblastic sarcoma of man. hyperplastic lymphoreticular lesions were induced in three additional animals; in two instances the hyperplastic lesions regressed. inapparent infection with development of antibody occured in eight animals. in two animals there was no evidence of ebv infection. one animal died in the first week after inoculation o ... | 1977 | 192829 |
| concanavalin a and the production of bovine leukemia virus antigen in short-term lymphocyte cultures. | the influence of the mitogen concanavalin a (con a) on the production of bovine leukemia virus (blv) antigen in short-term lymphocyte cultures was determined by means of a single radial immunodiffusion test. con a did not affect viral antigen production in peripheral blood lymphocytes from 60% of both experimentally and naturally infected cattle. antigen production was stimulated by con a in lymphocytes from 28% of the cattle, but it was inhibited in lymphocytes from 12%. similar results were al ... | 1977 | 192904 |
| composition of some urinary calculi of ruminants in western australia. | forty ruminant urinary calculi, selected as being essentially inorganic and mainly obtained from sheep grazing in the drier wheatbelt areas of western australia, were examined by optical and x-ray diffraction techniques. four mineral types-silica (sio2-nh2o), weddellite (cac2o4-2h2o), calcite (caco3) and aragonite (caco3)--were found. these minerals were present respectively in 30, 17, 13 and 1 of the 40 calculi examined and were the sole component in 12, 0, 7, and 0 calculi. one calculus was fo ... | 1976 | 193170 |
| immunoglobulins in the serum and nasal secretions of lambs following vaccination and aerosol challenge with parainfluenza 3 virus. | serial changes in the concentrations of igm, igg and iga were compared in specific pathogen free (spf) lambs which had been vaccinated with live or inactivated parainfluenza 3 virus (pi 3) by either intramuscular (im) or intranasal (in) routes followed by aerosol challenge with pi 3. in the serum, an increase in igm was associated with the primary antibody response to the aerosol challenge, whereas increased igg was associated with the secondary antibody response. no changes in immunoglobulin co ... | 1976 | 193171 |
| [effect of somatotropic hormone on certain indices related to carbohydrate and fat metabolism in sheep]. | investigated was the effect of the somatotropic hormone (sth) at doses of 0.3 mg/kg and 1 mg/kg liveweight on the amount of insulin, glucose, and free fatty acids (ffa) in the serum up to the 12th hour following treatment. the activity of glucose-6-phosphatase and the amount of glycogen were studied in tissue samples taken through biopsy of the liver at the 2nd, 4th, 6th, and 8th hour after treatment with sth. the content of blood sugar decreased, and that of insulin increased in the course of o ... | 1976 | 193239 |
| [use of the passive hemagglutination test for the purpose of determining antibody levels following animal immunization with cl. perfringens toxoid]. | data are presented on the study of possibilities of the application of the passive hemagglutination test for titration of the blood sera of mice, guinea pigs and rabbits immunized with cl. perfringens toxoid. a diagnostic agent obtained by the sensitization of formalin- and tannin-treated sheep erythrocytes with the serologically pure toxoid, and homologous sera (as standard) were used in this test. a high immune response of balb/c and c3h mice to the cl. perfringens toxoid permits to suggest in ... | 1977 | 193324 |
| the activity of some nucleolytic enzymes in semen and in the secretion of the male reproductive tract. | the activity of 5'-nucleotidase (ec 1.3.5), cyclic nucleotide phosphodiesterase (ec 2.1.4.17), non-specific phosphodiesterase (ec 3.1.4.1) and ribonuclease (ec 1.7.7.16)has been investigated in the seminal plasma of whole semen and in the secretions of the seminal vesicle, prostate and epididymis of the bull, boar, ram, stallion, jackass, rabbit and man. bull seminal plasma showed the highest activity for 5'-nucleotidase, cyclic nucleotide phosphodiesterase and ribonuclease; in contrast, stallio ... | 1977 | 193415 |
| the interaction of 4-alkyl derivatives of 2,6,7-trioxa-1-phosphabicyclo [2,2,2] octanes with cyclic adenosine 3',5'-monophosphate phosphodiesterase, and with cyclic adenosine 3',5'-monophosphate binding proteins. | | 1977 | 193519 |
| [effect of conditioned reflex factors on the motor and bioelectrical activity of the stomach in small ruminants under the influence of acth]. | | 1977 | 193740 |
| direct serological assay for the heat-labile enterotoxin of escherichia coli, using passive immune hemolysis. | sheep erythrocytes sensitized with the heat-labile enterotoxin (lt) of escherichia coli exhibited passive immune hemolysis (pih) when exposed to specific antitoxin and complement. thus, pih serves as the basis for an in vitro serological assay for lt that is sufficiently specific and sensitive to differentiate lt-positive and lt-negative e. coli isolates. the pih assay for e. coli lt has been performed with the standard microtiter system and also by a tube method employing the spectrophotometri ... | 1977 | 193793 |
| the effect of dietary fats on the plasma lipid composition of sheep. | | 1977 | 194131 |
| detection of poliovirus antigens and antibodies: microindirect haemagglutination and haemagglutination inhibition tests for poliovirus types i, ii, and iii. | microtitre indirect haemagglutination (iha) and iha-inhibition (ihai) procedures were adapted to determine the reactivities of type i, ii, and iii poliovirus antibodies and antigens. glutaraldehyde-fixed sheep erythrocytes were sensitized for these tests with concentrated, partially purified preparations of type i, ii, and iii poliovirus. antibody titres by iha were generally 10 to 100 times greater than serum microneutralization (sn) titres. the sn and iha reactivities of three kinds of sera we ... | 1976 | 194134 |
| the appearance of gluconeogenesis at birth in sheep. activation of the pathway associated with blood oxygenation. | 1. measurements of pyruvate carboxylase, mitochondrial phosphoenolpyruvate carboxykinase (gtp), hexose bisphosphatase and glucose 6-phosphatase in developing sheep liver showed substantial activities of all enzymes in the foetus, especially towards the end of gestation. cytosol phosphoenolpyruvate carboxykinase (gtp) in livers of mid-term foetuses was only 10% of the activity at birth. 2. all enzymes except pyruvate carboxylase showed 1.5-2-fold increases after birth. 3. gluconeogenesis form [14 ... | 1977 | 194581 |
| some properties of aldehyde dehydrogenase from sheep liver mitochondria. | aldehyde dehydrogenase from sheep liver mitochondria was purified to homogeneity as judged by electrophoresis on polyacrylamide gels, and by sedimentation-equilibrium experiments in the analytical ultracentrifuge. the enzyme has a molecular weight of 198000 and a subunit size of 48000, indicating that the molecule is a tetramer. fluorescence and spectrophotometric titrations indicate that each subunit can bind 1 molecule of nadh. enzymic activity is completely blocked by reaction of 4mol of 5,5' ... | 1977 | 194582 |
| simultaneous presence of receptors for complement and sheep red blood cells on human fetal thymocytes. | the cells of four thymus glands, two at 12 weeks, one at 16 weeks and one at 22 weeks gestational age, were examined cytochemically for enzymic activity and for surface markers. the reactions for chloroacetate esterase, peroxidase, and alkaline phosphatase were negative and the reaction for nonspecific esterase was only weakly positive in some of the cells. in contrast, nearly all thymocytes at the 12th gestational week showed strong focal acid phosphatase (acp) activity. the number of acp-stain ... | 1977 | 194621 |
| intercellular immunological controls and modulation of cyclic amp levels. some doubts. | we have re-examined two sets of observations put forward to support the hypothesis that rises in camp levels induced by vasoactive amines and prostaglandins are involved in the intercellular control of immunological and inflammatory processes. (1) this hypothesis is said to be supported by the fact that cholera toxin, which raises camp levels in lymphoid tissue in vivo, is immunosuppressive. however, we found that cholera toxin inhibited antibody production only if given in doses causing gross d ... | 1976 | 194828 |