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structural analysis of covid-19 spike protein in recognizing the ace2 receptor of different mammalian species and its susceptibility to viral infection.the pandemic covid-19 was caused by a novel coronavirus-2 (sars-cov-2) that infects humans through the binding of glycosylated sars-cov-2 spike 2 protein to the glycosylated ace2 receptor. the spike 2 protein recognizes the n-terminal helices of the glycosylated metalloprotease domain in the human ace2 receptor. to understand the susceptibility of animals for infection and transmission, we did sequence and structure-based molecular interaction analysis of 16 ace2 receptors from different mammali ...202133552834
zinc finger antiviral protein (zap) inhibits small ruminant morbillivirus replication in vitro.small ruminant morbillivirus (srmv) is a highly contagious and economically important viral disease of small domestic and wild ruminants. difficulty with its stable proliferation in ovis aries-derived cells has led to a relative lag in the study of its natural immunity and pathogenesis. here we report the antiviral properties of zap against srmv, a single-stranded negative-stranded rna virus of the genus morbillivirus. zap expression was significantly induced in sheep endometrial epithelial cell ...202134311269
monitoring of bluetongue virus in zoo animals in spain, 2007-2019.bluetongue (bt) is an emerging and re-emerging communicable vector-borne disease of animal health concern. a serosurvey was performed to assess exposure to bt virus (btv) in zoo animals in spain and to determine the dynamics of seropositivity in longitudinally sampled individuals during the study period. serum samples were collected from 241 zoo animals belonging to 71 different species in five urban zoos (a-e) in spain between 2007 and 2019. twenty-four of these animals were longitudinally surv ...202133963677
insertion of an endogenous jaagsiekte sheep retrovirus element into the bco2 - gene abolishes its function and leads to yellow discoloration of adipose tissue in norwegian spælsau (ovis aries).the accumulation of carotenoids in adipose tissue leading to yellow fat is, in sheep, a heritable recessive trait that can be attributed to a nonsense mutation in the beta-carotene oxygenase 2 (bco2) gene. however, not all sheep breeds suffering from yellow fat have this nonsense mutation, meaning that other functional mechanisms must exist. we investigated one such breed, the norwegian spælsau.202134193038
zoo animals as sentinels for schmallenberg virus monitoring in spain.schmallenberg virus (sbv) is a newly emerged vector-borne pathogen that affects many domestic and wild animal species. a serosurvey was carried out to assess sbv exposure in zoo animals in spain and to determine the dynamics of seropositivity in longitudinally sampled individuals. between 2002 and 2019, sera from 278 animals belonging to 73 different species were collected from five zoos (a-e). thirty-one of these animals were longitudinally sampled at three of these zoo parks during the study p ...202033243564
proteomic profiles and cytokeratin 13 as a potential biomarker of ovis aries papillomavirus 3-positive and negative cutaneous squamous cell carcinomas.ovis aries papillomavirus 3 (oapv3) is an epidermotropic pv reported in sheep cutaneous squamous cell carcinoma (scc). the presence of oapv3 dna and its transcriptional activity in cutaneous scc, as well as its in vitro transforming properties, suggest a viral etiology for this neoplasm. nevertheless, the reactome associated with viral-host interaction is still unexplored. here, we investigated and compared the proteomic profiles of oapv3-positive sccs, oapv3-negative sccs, and non-scc samples b ...202033360571
increased plasma melatonin in presymptomatic huntington disease sheep (ovis aries): compensatory neuroprotection in a neurodegenerative disease?melatonin is a pleiotrophic hormone, synthesised primarily by the pineal gland under the control of the suprachiasmatic nuclei (scn). it not only provides a hormonal signal of darkness but also has neuroprotective properties. huntington's disease (hd) is a progressive neurodegenerative disorder characterised by abnormal motor, cognitive and psychiatric symptoms. there is growing evidence, particularly from animal models, that circadian rhythms may also be disturbed in hd. we measured two circadi ...202031742766
imgt® biocuration and comparative study of the t cell receptor beta locus of veterinary species based on homo sapiens trb.imgt®, the international immunogenetics information system® is the global reference in immunogenetics and immunoinformatics. by its creation in 1989 by marie-paule lefranc (université de montpellier and cnrs), imgt® marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. imgt® is specialized in the immunoglobulins (ig) or antibodies, t cell receptors (tr), major histocompatibility (mh), and proteins of the igsf and mhsf superfamilies. t c ...202032431713
ecology eclipses phylogeny as a major driver of nematode parasite community structure in a graminivorous primate.understanding the relative strength of ecology and phylogeny in shaping parasite communities can inform parasite control and wildlife conservation initiatives while contributing to the study of host species evolution.we tested the relative strengths of phylogeny and ecology in driving parasite community structure in a host whose ecology diverges significantly from that of its closest phylogenetic relatives.we characterized the gastrointestinal (gi) parasite community of wild geladas (theropithec ...202033071424
minimizing the risk of occupational q fever exposure: a protocol for ensuring coxiella burnetii-negative pregnant ewes are used for medical research.q fever is a worldwide zoonosis caused by coxiella burnetii that can lead to abortion, endocarditis, and death in humans. researchers utilizing parturient domestic ruminants, including sheep, have an increased risk of occupational exposure. this study evaluated the effectiveness of our screening protocol in eliminating c. burnetii-positive sheep from our facility. from august 2010 to may 2018, all ewes (n  =  306) and select lambs (n  =  272; ovis aries) were screened twice for c. burnetii utili ...202033108940
expression of calcification and extracellular matrix genes in the cardiovascular system of the healthy domestic sheep (ovis aries).the maintenance of a healthy cardiovascular system requires expression of genes that contribute to essential biological activities and repression of those that are associated with functions likely to be detrimental to cardiovascular homeostasis. vascular calcification is a major disruption to cardiovascular homeostasis, where tissues of the cardiovascular system undergo ectopic calcification and consequent dysfunction, but little is known about the expression of calcification genes in the health ...202033101359
deleterious agxt missense variant associated with type 1 primary hyperoxaluria (ph1) in zwartbles sheep.severe oxalate nephropathy has been previously reported in sheep and is mostly associated with excessive oxalate in the diet. however, a rare native dutch breed (zwartbles) seems to be predisposed to an inherited juvenile form of primary hyperoxaluria and no causative genetic variant has been described so far. this study aims to characterize the phenotype and genetic etiology of the inherited metabolic disease observed in several purebred zwartbles sheep. affected animals present with a wide ran ...202033003365
rumen microbiome and metabolome of tibetan sheep (ovis aries) reflect animal age and nutritional requirement.the rumen microbiota plays an important role in animal functional attributes. these microbes are indispensable for the normal physiological development of the rumen, and may also convert the plant polysaccharides from grass into available milk and meat, making it highly valuable to humans. exploring the microbial composition and metabolites of rumen across developmental stages is important for understanding ruminant nutrition and metabolism. however, relatively few reports have investigated the ...202032984417
enterocytozoon bieneusi genotypes in farmed goats and sheep in ningxia, china.enterocytozoon bieneusi is reported to be a common microsporidian of humans and animals in various countries. however, scarce information on e. bieneusi has been recorded in farmed goats and sheep in china. as such, we undertook molecular epidemiological investigation of e. bieneusi in farmed goats (capra aegagrus hircus) and sheep (ovis aries) in ningxia, china. a total of 660 genomic dnas were extracted from individual faecal samples from famed goats (n = 300) and sheep (n = 360), and then tes ...202032961363
accidental chlorophacinone exposure of lactating ewes: clinical follow-up and human health dietary implications.anticoagulant rodenticides are widely used for rodent control in agricultural and urban settings. their intense use can sometimes result in accidental exposure and even poisoning of livestock. can milk, eggs or meat derived from such accidently exposed animals be consumed by humans? data on the pharmacokinetics of chlorophacinone in milk of accidently exposed ewes were used to estimate the risk associated with its consumption. three days after accidental ingestion, chlorophacinone was detected i ...202032645465
the structure of a novel membrane-associated 6-phosphogluconate dehydrogenase from gluconacetobacter diazotrophicus (gd6pgd) reveals a subfamily of short-chain 6pgds.the enzyme 6-phosphogluconate dehydrogenase catalyzes the conversion of 6-phosphogluconate to ribulose-5-phosphate. it represents an important reaction in the oxidative pentose phosphate pathway, producing a ribose precursor essential for nucleotide and nucleic acid synthesis. we succeeded, for the first time, to determine the three-dimensional structure of this enzyme from an acetic acid bacterium, gluconacetobacter diazotrophicus (gd6pgd). active gd6pgd, a homodimer (70 kda), was present in bo ...202032621793
a novel swine sex-linked marker and its application across different mammalian species.advances in genome editing tools have reduced barriers to the creation of animal models. due to their anatomical and physiological similarities to humans, there has been a growing need for pig models to study human diseases, for xenotransplantation and translational research. the ability to determine the sex of genetically modified embryos, cells or fetuses is beneficial for every project involving the production of transgenic animals. this strategy can improve the time-efficiency and lower the ...202032607872
characteristic patterns of eeg oscillations in sheep (ovis aries) induced by ketamine may explain the psychotropic effects seen in humans.ketamine is a valuable anaesthetic and analgesic that in recent years has gained notoriety as a recreational drug. recently, ketamine has also been proposed as a novel treatment for depression and post-traumatic stress disorder. beyond its anaesthetic actions, however, the effects of ketamine on brain activity have rarely been probed. here we examined the cortical electroencephalography (eeg) response to ketamine of 12 sheep. following ketamine administration, eeg changes were immediate and wide ...202032528071
prevalence and multilocus genotyping of giardia duodenalis in tan sheep (ovis aries) in northwestern china.giardia duodenalis is a common intestinal protozoa, which can cause the occurrence of diarrhea, weight loss, and even death in animals or human, this threatens the husbandry industry and public health. it can infect virtually humans and all domestic animals including sheep. tan sheep is one of the most important sheep breeds, which is short-tailed indigenous sheep breed used for production of high quality meat and pelts in china. however, there are no report regarding the occurrence and multiloc ...202032334094
choosing what is left: the spatial structure of a wild herbivore population within a livestock-dominated landscape.shrublands and grasslands comprise over 30% of the land surface and are among the most exploited ecosystems for livestock production. across natural landscapes, the distribution and abundance of wild herbivores are affected by interspecific competition for foraging resources, hunting and the development of infrastructure among other factors. in argentine patagonia, the abundance of domestic sheep grazing on native vegetation outnumbers the widely distributed guanaco (lama guanicoe) and sheep ran ...202032296614
novel insights into cardiac regeneration based on differential fetal and adult ovine heart transcriptomic analysis.the adult mammalian cardiomyocyte has a very limited capacity to reenter the cell cycle and advance into mitosis. therefore, diseases characterized by lost contractile tissue usually evolve into myocardial remodeling and heart failure. analyzing the cardiac transcriptome at different developmental stages in a large mammal closer to the human than laboratory rodents may serve to disclose positive and negative cardiomyocyte cell cycle regulators potentially targetable to induce cardiac regeneratio ...202032167779
characterizing sleep spindles in sheep.sleep spindles are distinctive transient patterns of brain activity that typically occur during non-rapid eye movement (nrem) sleep in humans and other mammals. thought to be important for the consolidation of learning, they may also be useful for indicating the progression of aging and neurodegenerative diseases. the aim of this study was to characterize sleep spindles in sheep (ovis aries). we recorded electroencephalographs wirelessly from six sheep over a continuous period containing 2 night ...202032122958
detection of antimicrobial resistance genes in escherichia coli isolated from black howler monkeys (alouatta pigra) and domestic animals in fragmented rain-forest areas in tabasco, mexico.the appearance and spread of antimicrobial resistance (amr) in bacteria in natural environments and wildlife are related to agricultural and livestock activities and are a global health and conservation problem. we assessed the presence of amr genes in escherichia coli isolated from black howler monkeys (alouatta pigra), sheep (ovis aries), cattle (bos taurus), and horses (equus caballus) from a highly fragmented forest in southern mexico. fresh fecal samples were collected using swabs, seeded o ...202032402234
deer keds on wild ungulates in northern italy, with a taxonomic key for the identification of lipoptena spp. of europe.deer keds (lipoptena spp.) are blood-sucking ectoparasites of domestic and wild animals, and also accidentally of humans. in europe, five lipoptena spp. have been recorded, although the lack of specific taxonomic keys has often led to mistaken identification or to missing data. the present study aimed to develop an identification key of the european species and also to identify lipoptena spp. found on wild ungulates in northern italy. in total, 390 hippoboscids were collected from rupicapra rupi ...202031674696
molecular characterization and protein structure prediction of heat shock transcriptional factors in goat (capra hircus) and sheep (ovis aries).the heat shock factors are important as they are master regulator of heat shock response. there are only few mammalian hsfs which have been characterized, namely hsf-1, hsf-2, hsf-4 and hsf-5. the present study was aimed to clone and sequence characterize the partial open reading frames (orfs) of hsf-2 and hsf-5 gene from cdna isolated from testicular tissue of sheep (macheri) and goat (beetal). the partial orfs of hsf-2 gene was observed to be 1627 bp in sheep and 1179 bp in goat and for hsf-5 ...202031164037
exposure to toxoplasma gondii in zoo animals in spain.a serosurvey was performed to assess exposure to toxoplasma gondii in zoo animals in spain and to determine the dynamics of seropositivity in some zoo species over time. sera from 393 zoo animals belonging to 91 species were collected in eight zoos in spain between 2007 and 2019. additionally, 39 of the 393 animals from five of the analyzed zoos were longitudinally sampled during the same study period. antibodies to t. gondii were detected in 165 (42.0 %; ci95 %: 37.1-46.9) of 393 animals by the ...202032109781
detection of porcine circovirus 3 in wildlife species in spain.porcine circovirus 3 (pcv-3) is the third member of the family circoviridae, genus circovirus, able to infect swine. a high prevalence of viral dna has been recorded in wild boars. recently, pcv-3 dna was identified in italian wild ruminants. based on these previous results, this study assessed the frequency of pcv-3 dna detection in free-ranging ruminants and lagomorpha species in spain. in addition, the genetic characterization of the pcv-3 pcr-positive samples was performed. a total of 801 se ...202032369945
rapid pcr-free meat species mitochondrial dna identification using electric field induced release and measurement (efirm®).this work details the usage of efirm® (electric field induced release and measurement) for pcr-free rapid electrochemical detection of mitochondrial dna. efirm® was able to perform highly sensitive detection of animal species for meat contamination testing without multistep sample lysis, dna extraction, or pcr amplification steps, demonstrating the capability to detect the presence of foreign meat species that only constituted 0.1% of the total mass of a food sample (achieving sensitivity equiva ...202031986279
aestipascuomycesdupliciliberans gen. nov, sp. nov., the first cultured representative of the uncultured sk4 clade from aoudad sheep and alpaca.we report on the isolation of the previously-uncultured neocallimastigomycota sk4 lineage, by two independent research groups, from a wild aoudad sheep rumen sample (texas, usa) and an alpaca fecal sample (baden-württemberg, germany). isolates from both locations showed near-identical morphological and microscopic features, forming medium-sized (2-5 mm) white filamentous colonies with a white center of sporangia, on agar roll tubes and a heavy biofilm in liquid media. microscopic analysis reveal ...202033167420
endemic occurrence of fasciola hepatica in an alpine ecosystem, pyrenees, northeastern spain.fasciola hepatica is a liver parasite of ruminants whose distribution is determined by its intermediate host, the freshwater snail galba truncatula. in europe, f. hepatica is mostly associated with lowlands. infection from sympatric domestic reservoirs is rarely reported in wild mountain ungulates. this study explores f. hepatica in a multi-host system in a european alpine area. serum samples (n = 1,209) from pyrenean chamois (rupicapra p. pyrenaica), european mouflon (ovis aries musimon), domes ...202033012085
evolutionary-driven c-myc gene expression in mammalian fibroblasts.the extent to which mammalian cells share similar transcriptomes remains unclear. notwithstanding, such cross-species gene expression inquiries have been scarce for defined cell types and most lack the dissection of gene regulatory landscapes. therefore, the work was aimed to determine c-myc relative expression across mammalian fibroblasts (ovis aries and bos taurus) via cross-species rt-qpcr and comprehensively explore its regulatory landscape by in silico tools. the prediction of transcription ...202032632086
cytogenetic characterization of a small evolutionary rearrangement involving chromosomes bta21 and oar18.both cattle (bos taurus) and sheep (ovis aries) belong to the bovidae family but to different subfamilies, bovinae and caprinae, respectively. from a chromosomal point of view, apart from the already known centric fusions (that occurred during the evolutionary process in the bovidae family) and the small differences in the chromosome classification, the 2 karyotypes are very similar in banding patterns. in this study, the combination of bioinformatics techniques and physical mapping of dna marke ...202032485720
identification of some errors in the genome assembly of bovidae by fish.from an economic point of view, bovidae represent the most important family of the ruminantia suborder. thus, the mitochondrial and nuclear genomes of bos taurus were among the first genomes to be sequenced after the sequencing of the human genomes. over the millennia, the evolution of the genomes of the 3 main species belonging to the bovidae family - b. taurus (bta), ovis aries (oar), and capra hircus (chi) - has led to few chromosome rearrangements. certainly, the availability and free access ...202032235117
functional and molecular characterization of endothelium-dependent and endothelium-independent relaxant pathways in uterine artery of non-pregnant buffaloes.present study was undertaken to unravel the endothelium-dependent and endothelium-independent relaxant pathways in uterine artery of non-pregnant buffaloes. isometric tension of arterial rings was recorded using data acquisition system based polyphysiograph. acetylcholine (ach) produced endothelium-dependent vasorelaxation by releasing nitric oxide (no), and inhibition of nitric oxide synthase (nos) by l-name (300 μm) significantly (p < 0.05) reduced the no release and thereby the vasorelaxant e ...202031494705
the growth of domestic goats and sheep: a meta study with bertalanffy-pütter models.growth literature often uses the brody, gompertz, verhulst, and von bertalanffy models. is there a rationale for the preference of these classical named models? the versatile five-parameter bertalanffy-pütter (bp) model generalizes these models. we revisited peer-reviewed publications from the years 1970-2019 that fitted growth models to together 122 mass-at-age data of sheep and goats from 19 countries and studied the best-fit bp-models using the least-squares method. none of the named models w ...202032885092
parasites of markhor, urial and chiltan wild goat in pakistanparasites are transferred between domestic and wild animals, when host animals come in contact with each other, particularly while grazing the same pastures, or when using same water bodies for drinking. chances of parasite transmission and adaptation are high when hosts are genetically related. afghan urial (ovis vignei blanfordi), suleiman markhor (capra falconeri jerdoni) and chiltan wild goat (c. aegagrus chialtanensis) are wild kin of domestic sheep and goats, sharing numerous parasitic dis ...202032198990
prevalence, genotypic and phenotypic characterization and antibiotic resistance profile of clostridium perfringens type a and d isolated from feces of sheep (ovis aries) and goats (capra hircus) in punjab, pakistan.clostridium perfringens poses a serious threat to small ruminants by causing moderate to severe enterotoxaemia. due to its ability to produce a wide arsenal of toxins, it is ranked among the most prevalent and important pathogens in livestock. this study focused on the molecular characterization of different clostridium perfringens types along with their antimicrobial resistance profile. an overall higher prevalence of c. perfringens (46.1%) was detected based on mpcr among sheep and goats (heal ...202033066416
a novel recombinant newcastle disease virus vectored diva vaccine against peste des petits ruminants in goats.peste des petits ruminants virus (pprv, species: small ruminant morbillivirus) is the causative agent of the eponymous notifiable disease, the peste des petits ruminants (ppr) in wild and domestic sheep and goats. mortality rates vary between 50% and 100%, causing significant losses of estimated 1.5 to 2 billion us dollars per year. live-attenuated pprv vaccine strains are used in the field for disease prevention, but the application of a more thermostable vaccine enabling differentiation betwee ...202032354145
influence of testosterone administration at the end of the breeding season on sperm cryoresistance in rams (ovis aries) and bucks (capra hircus).this study examines the influence of administering testosterone at the end of the mating season, on the responses (morphometric and functional) of ram and buck sperm to freezing-thawing. five rams were administered 25 mg testosterone propionate (tp) subcutaneously in 2 ml of olive oil twice per week (monday and thursday) from october 1 to 31; 5 bucks received exactly the same treatment but from november 1 to 30. control groups were administered 2 ml of olive oil without tp twice per week over th ...202032278257
proteomic characterization and comparison of ram (ovis aries) and buck (capra hircus) spermatozoa proteome using a data independent acquisition mass spectometry (dia-ms) approach.fresh semen is most commonly used in an artificial insemination of small ruminants, because of low fertility rates of frozen sperm. generally, when developing and applying assisted reproductive technologies, sheep and goats are classified as one species. in order to optimize sperm cryopreservation protocols in sheep and goat, differences in sperm proteomes between ram and buck are necessary to investigate, which may contribute to differences in function and fertility of spermatozoa. in the curre ...202032053710
morphological and molecular characterization of a species of tetratrichomonas present in feces of brazilian sheep (ovis aries) and goats (capra hircus).the trichomonads form part of the phylum parabasalia, a complex assemblage of diverse species of flagellated protists, with some members recognized as pathogens of men and/or animals. associations, probably as commensals, between the species tetratrichomonas ovis and sheep were reported in north america during the 1960s based on morphological and cultural characteristics. intriguingly, no subsequent studies of this topic have been published. feces, collected from sheep (n = 55) and goats (n = 14 ...202031745635
molecular characterization of tick-borne bacteria and protozoans in yaks (bos grunniens), tibetan sheep (ovis aries) and bactrian camels (camelus bactrianus) in the qinghai-tibetan plateau area, china.due to the specific plateau climate, a variety of unique animals live in the qinghai-tibetan plateau area (qtpa) including yaks (bos grunniens), tibetan sheep (ovis aries) and bactrian camels (camelus bactrianus). however, information on tick-borne diseases (tbds) in the qtpa and on the molecular characteristics of tick-borne pathogens (tbps) in the area is limited. therefore, the aim of this study was to investigate anaplasma spp., babesia spp., theileria spp., borrelia burgdorferi sensu lato a ...202032723655
distribution of pestivirus exposure in wild ruminants in spain.a large-scale study was carried out to determine the prevalence of antibodies against pestivirus species in wild ruminants and describe their spatial variation in mainland spain. serum samples of 1,874 wild ruminants from different regions of this country were collected between the years 2000 and 2017. a total of 6.6% (123/1,874) animals showed antibodies against pestivirus by both blocking elisa (belisa) and virus neutralization tests (vnt). the prevalence of antibodies against pestiviruses was ...202032920992
serosurveillance of schmallenberg virus in wild ruminants in spain.schmallenberg disease (sbd) is an emerging vector-borne disease that affects domestic and wild ruminants. a long-term serosurvey was conducted to assess exposure to schmallenberg virus (sbv) in all the wild ruminant species present in mainland spain. between 2010 and 2016, sera from 1,216 animals were tested for antibodies against sbv using a commercial blocking elisa. the overall prevalence of antibodies was 27.1% (95%ci: 24.7-29.7). statistically significant differences among species were obse ...202032530115
identifying maintenance hosts for infection with dichelobacter nodosus in free-ranging wild ruminants in switzerland: a prevalence study.footrot is a worldwide economically important, painful, contagious bacterial foot disease of domestic and wild ungulates caused by dichelobacter nodosus. benign and virulent strains have been identified in sheep presenting with mild and severe lesions, respectively. however, in alpine ibex (capra ibex ibex), both strains have been associated with severe lesions. because the disease is widespread throughout sheep flocks in switzerland, a nationwide footrot control program for sheep focusing on vi ...202031917824
seroprevalence of small ruminant lentivirus (srlv) infection in wild cervids in poland.small ruminant lentiviruses (srlv) are widespread amongst domesticated sheep and goats worldwide. infection of wild ruminants in close contact with affected domesticated small ruminants has been proposed as an actor in srlv epidemiology, but studies are limited. the aim of this study was to estimate the apparent (ap) and estimated prevalence (ep) of exposure to srlv infection in wild ruminants from poland. samples originating from 198 free-living cervids comprising 142 european red deer and 56 r ...202032004826
ericaceous species reduce methane emissions in sheep and red deer: respiration chamber measurements and predictions at the scale of european heathlands.despite the importance of atmospheric methane as a potent greenhouse gas and the significant contribution from ruminant enteric fermentation on methane emissions at a global scale, little effort has been made to consider the influence that different plant-based natural diets have on methane emissions in grazing systems. heathland is an ericaceous dwarf-shrub-dominated habitat widespread across the northern hemisphere, in europe, provides valuable ecosystem services in areas with poor soils, such ...202031982753
in vitro supplementation of testosterone or prolactin affects spermatozoa freezability in small ruminants.in small ruminants, testosterone and prolactin plasma concentrations show circannual fluctuations as an adaptation mechanism to their seasonal breeding behavior. sperm resistance to the freezing-thawing process shows seasonal fluctuation throughout the year, with lower sperm freezability at the beginning of the breeding season when prolactin and testosterone levels reach their maximum concentration. nevertheless, whether these hormones directly affect post-thaw sperm quality parameters is still ...202031431310
compound heterozygous pla2g6 loss-of-function variants in swaledale sheep with neuroaxonal dystrophy.sporadic occurrences of neurodegenerative disorders including neuroaxonal dystrophy (nad) have been previously reported in sheep. however, so far no causative genetic variant has been found for ovine nad. the aim of this study was to characterize the phenotype and the genetic aetiology of an early-onset neurodegenerative disorder observed in several lambs of purebred swaledale sheep, a native english breed. affected lambs showed progressive ataxia and stiff gait and subsequent histopathological ...202033159255
assay to compare cell- and antibody-mediated immune responses in domestic sheep and goats.assessment of immune fitness is valuable in many aspects of livestock management and research. determining immune consequences of selection for increased disease resistance or inhabiting various environments or climates can lead to different management decisions. the ability to measure immune responses due to different diets, pregnancy status, or aging will increase insight about how these factors contribute to overall immune health. the main objective of these experiments was to adapt a methodo ...202033137678
topographical and structural characterization of the v1-v2 transition zone in the visual cortex of the long-finned pilot whale globicephala melas (traill, 1809).the visual system of cetaceans is at best poorly understood. with a handful of electrophysiological studies and a limited number of histological preparations from well-preserved specimen, the investigation of the principles underlying the cortical organization in cetaceans remains a challenge. in the course of our current investigation, we identified the transition from v2 to v1 in the long-finned pilot whale globicephala melas, only recognizable through immunocytochemistry, and a similar if not ...202033119932
integrated analysis of mirna-mrna interaction in ovaries of turpan black sheep during follicular and luteal phases.to investigate the regulatory mechanism of the follicular-luteal phase transition in turpan black sheep (ovis aries), the genome-wide expression patterns of micrornas (mirnas) and genes were investigated in ovaries of six sheep (3 years and single lamb with 3 consecutive births) during follicular and luteal phases of the oestrous cycle. bioinformatic analysis was used to screen potential mirnas and genes related to turpan black sheep ovarian function. rt-qpcr was used to validate the sequencing ...202033098173
retroviral analysis reveals the ancient origin of kihnu native sheep in estonia: implications for breed conservation.native animal breeds constitute an invaluable pool of genetic resources in a changing environment. discovering native breeds and safeguarding their genetic diversity through specific conservation programs is therefore of high importance. endogenous retroviruses have proved to be a reliable genetic marker for studying the demographic history of sheep (ovis aries). previous research has revealed two migratory episodes of domesticated sheep from the middle east to europe. the first episode included ...202033060653
the use of a "go/go" cognitive bias task and response to a novel object to assess the effect of housing enrichment in sheep (ovis aries).it is widely acknowledged that environmental enrichment can improve animals' welfare and emotional state. this study used cognitive bias and response to a novel object to assess the effect of enriched housing on emotional state in sheep. eighteen sheep were trained to discriminate between high-quality and low-quality reward locations using a go/go task. sheep were allocated to a housing treatment (enriched or standard) for three weeks. judgment bias tests were conducted using three ambiguous, un ...202033054369
comparison of the microbial communities of alpacas and sheep fed diets with three different ratios of corn stalk to concentrate.the objective of this study was to investigate the characteristics of ruminal microbial communities of alpacas (lama pacos) and sheep (ovis aries) fed three diets with varying ratios of roughage (corn stalk) to concentrate, 3:7 (ls), 5:5 (ms) and 7:3 (hs). six alpacas (one-year-old and weighing 29.5 ± 7.1 kg) and six sheep (one-year-old and weighing 27.9 ± 2.7 kg) were used in this study, in a replicated 3 × 3 latin square experiment. total protozoa concentration was determined under the microsc ...202033029865
a hu sheep genome with the first ovine y chromosome reveal introgression history after sheep domestication.the y chromosome plays key roles in male fertility and reflects the evolutionary history of paternal lineages. here, we present a de novo genome assembly of the hu sheep with the first draft assembly of ovine y chromosome (omsy), using nanopore sequencing and hi-c technologies. the omsy that we generated spans 10.6 mb from which 775 y-snps were identified by applying a large panel of whole genome sequences from worldwide sheep and wild iranian mouflons. three major paternal lineages (hy1a, hy1b ...202032997330
historical introgression from wild relatives enhanced climatic adaptation and resistance to pneumonia in sheep.how animals, particularly livestock, adapt to various climates and environments over short evolutionary time is of fundamental biological interest. further, understanding the genetic mechanisms of adaptation in indigenous livestock populations is important for designing appropriate breeding programs to cope with the impacts of changing climate. here we conducted a comprehensive genomic analysis of diversity, interspecies introgression and climate-mediated selective signatures in a global sample ...202032941615
co-inherited novel snps of the lipe gene associated with increased carcass dressing and decreased fat-tail weight in awassi breed.the lipase e hormone-sensitive (lipe) enzyme is one of the lipolytic enzymes, and it plays a key role in the regulation of adipose tissue deposition. this study was conducted to investigate the possible association between the lipe gene variations and the main body weight measurements in awassi sheep. a total of 160 of sexually mature awassi rams (ovis aries) that aged between 2 and 3 years were included in the present study. genomic dna was extracted and two specific pcr amplicons were designed ...202032939705
analysis of whole genome resequencing datasets from a worldwide sample of sheep breeds to identify potential causal mutations influencing milk composition traits.different studies have shown that polymorphisms in the sequence of genes coding for the milk proteins and milk fatty acids are associated with milk composition traits as well as with cheese-making traits. however, the lack of coincident results across sheep populations has prevented the use of this information in sheep breeding programs. the main objective of this study was to exploit the information derived from a total of 175 whole genome resequencing (wgr) datasets from 43 domestic sheep bree ...202032882861
identification of polymorphisms in the oocyte-derived growth differentiation growth factor 9 (gdf9) gene associated with litter size in new zealand sheep (ovis aries) breeds.having the ability to control litter size is important for sheep farmers and breeders worldwide. however, making genetic gain in key livestock traits like reproductive performance needs typically a lot of time, and both the fecundity and fertility traits have a great economic importance. attention has therefore turned to better understanding the genes that control reproductive performance. of these genes, research has focussed on the growth differentiation growth factor 9 (gdf9) gene (gdf9). in ...202032865284
long noncoding rna (lncrna) cttn-it1 elevates skeletal muscle satellite cell proliferation and differentiation by acting as cerna for yap1 through absorbing mir-29a in hu sheep.characterizing the factors that regulate the growth and development of muscle is central to animal production. skeletal muscle satellite cells (smscs) provide an important material for simulating the proliferation and differentiation of muscle cells. yap1, which can promote muscle growth, is closely related to the proliferation of smscs in hu sheep (ovis aries). in addition, some mirnas, such as mir-541-3p, mir-142-5p, and mir-29a, can play critical roles in muscle growth by specifically binding ...202032849826
detection of ovis aries papillomavirus type 2 dna sequences in a sarcoid-like mass in the mouth of a pig.an oral mass was surgically excised from the gingiva of a pig. as the mass had a similar histological appearance to an equine sarcoid, dna was extracted and consensus pcr primers used to amplify papillomavirus (pv) dna. dna sequences from ovis aries papillomavirus (oapv) type 2 were amplified both from a section of the entire mass as well as an area deeper within the mass away from the surface of the lesion. no other pv types were detected within the oral lesion. ovis aries pv2 is a delta pv tha ...202032827929
the oligomeric assembly of galectin-11 is critical for anti-parasitic activity in sheep (ovis aries).galectins are a family of glycan-binding molecules with a characteristic affinity for ß-d-glycosides that mediate a variety of important cellular functions, including immune and inflammatory responses. galectin-11 (lgals-11) has been recently identified as a mediator induced specifically in animals against gastrointestinal nematodes and can interfere with parasite growth and development. here, we report that at least two natural genetic variants of lgals-11 exist in sheep, and demonstrate fundam ...202032826940
paternal origins and migratory episodes of domestic sheep.the domestication and subsequent global dispersal of livestock are crucial events in human history, but the migratory episodes during the history of livestock remain poorly documented [1-3]. here, we first developed a set of 493 novel ovine snps of the male-specific region of y chromosome (msy) by genome mapping. we then conducted a comprehensive genomic analysis of y chromosome, mitochondrial dna, and whole-genome sequence variations in a large number of 595 rams representing 118 domestic popul ...202032822607
effect of water scarcity during thermal-humidity exposure on the mineral footprint of sheep.combination of two stressors on alteration of mineral footprints in animals needs due attention to meet maximum production and welfare, particularly in grazing sheep. this study tested whether ewes (ovis aries) exposed to water deprivation and thermal-humidity stressors had altered mineral footprints in their wool, serum, urine, and feces.202032819082
genomic predictions for enteric methane production are improved by metabolome and microbiome data in sheep (ovis aries).methane production from rumen methanogenesis contributes approximately 71% of greenhouse gas emissions from the agricultural sector. this study has performed genomic predictions for methane production from 99 sheep across 3 yr using a residual methane phenotype that is log methane yield corrected for live weight, rumen volume, and feed intake. using genomic relationships, the prediction accuracies (as determined by the correlation between predicted and observed residual methane production) range ...202032815548
ear type in sheep is associated with the msrb3 locus.ear morphology is an important determinant of sheep breeds. it includes different variable traits such as ear size and erectness, suggesting a polygenic architecture. here, we performed a comprehensive genome-wide analysis to identify regions under selection for ear morphology in 515 sheep from 17 breeds fixed for diverse ear phenotypes using 34k snp genotyping data. gwass for two ear type traits, size and erectness, revealed a single genome-wide significant association on ovine chromosome 3. th ...202032805068
prevalence of eimeria species in sheep (ovis aries) from dakahlia governorate, egypt.feces from 184 sheep from dakahlia governorate, egypt were tested for eimeria species oocysts by using the standard floatation technique; oocysts were detected in 126 (68.4%). the prevalence was significantly higher in young sheep than adults. eleven eimeria species were identified: eimeria ahsata, eimeria bakuensis, eimeria crandallis, eimeria faurei, eimeria granulosa, eimeria intricata, eimeria marsica, eimeria ovinoidalis, eimeria pallida, eimeria parva and eimeria webybridgensis. oocysts of ...202032801508
identification and characterization of mirnas during early pregnancy in domestic sheep.microrna resources in sheep are limited compared with those in other domesticated mammalian species. by sequencing small rnas of sheep corpus luteum and endometrium, we have generated the largest amount of mirna-seq data and compiled the most comprehensive list thus far of mirnas (n = 599) in sheep. additionally, we observed a highly conserved maternally imprinted cluster of mirnas on chromosome 18 homologous to that found on chromosome 14 in human and several other eutherian mammals.202032794198
molecular analysis of polymorphic species of the genus marshallagia (nematoda: ostertagiinae).the genus marshallagia (family haemonchidae, subfamily ostertagiinae) contains multiple species of nematodes parasitising the abomasum (or duodenum) of ruminants, in particular of caprinae. male specimens have been described to be polymorphic with the frequent/major morphotype initially described in the genus marshallagia while the minor/rare morphotype was initially often placed in the genus grossospicularia. due to common morphological features, certain pairs of morphotypes were suggested to b ...202032787940
isolation and genetic characterization of toxoplasma gondii in spanish sheep flocks.toxoplasma gondii is a major cause of abortion in small ruminants and presents a zoonotic risk when undercooked meat containing cysts is consumed. the aim of the present study was to investigate the genetic diversity among the t. gondii strains circulating in ovine livestock in spain.202032758283
longitudinal magnetic resonance spectroscopy and diffusion tensor imaging in sheep (ovis aries) with quinolinic acid lesions of the striatum: time-dependent recovery of n-acetylaspartate and fractional anisotropy.we created an excitotoxic striatal lesion model of huntington disease (hd) in sheep, using the n-methyl-d-aspartate receptor agonist, quinolinic acid (qa). sixteen sheep received a bolus infusion of qa (75 µl, 180 mm) or saline, first into the left and then (4 weeks later) into the right striatum. magnetic resonance spectroscopy (mrs) and diffusion tensor imaging (dti) of the striata were performed. metabolite concentrations and fractional anisotropy (fa) were measured at baseline, acutely (1 we ...202032743645
genetic diversity in iranian indigenous sheep vis-à-vis selected exogenous sheep breeds and wild mouflon.the heterogeneity of climate and different agro-ecological conditions in iran have resulted in development of 27 indigenous sheep breeds. wild asiatic mouflon (ovis orientalis) is believed to be the ancestor of iranian sheep. evaluation of genetic diversity and population structure within and among domestic breeds has important implications for animal breeding programs and genetic resources management. based on 50k snp genotype data, we studied the genetic diversity of five indigenous iranian sh ...202032729152
association analysis between spp1, pofut1 and prlr gene variation and milk yield, composition and coagulation traits in sarda sheep.many studies focus on the identification of genomic regions that undergo selective processes, where evidence of selection is revealed and positional candidate genes are identified. the aim of the research was to evaluate the association between positional candidate genes, namely secreted phosphoprotein 1 (spp1, sheep chromosome ovis aries oar6, 36.651-36.658 mb), protein o-fucosyltransferase 1 (pofut1, oar13, 61.006-61.027 mb) and prolactin receptor (prlr, oar16, 38.969-39.028 mb) with milk yiel ...202032708940
mammary tissue transcriptomic analysis for construction of integrated regulatory networks involved in lactogenesis of ovis aries.the mammary gland experiences vast changes between the onset of lactation and pregnancy. this remodeling involves different functions such as lactation that is controlled by innumerable regulators and various gene networks which are still not completely understood. micrornas (mirnas) are one of the important non-coding gene regulators which control an extensive range of biological processes. thus, exploring mirnas functions is important for solving gene regulation complexity. the main purpose in ...202032693106
comparison of invasive and non-invasive blood pressure measurements in anesthetized female dorset cross-bred lambs (ovis aries).the purpose of this study was to determine the level of agreement between invasive and noninvasive blood pressure measurements in anesthetized, non-surgically manipulated dorset cross-bred lambs. twelve healthy female dorset cross-bred lambs, weighing 37.3 ± 7.4 kg (mean ± sd) underwent isoflurane anesthesia for simultaneous measurement of systolic arterial pressure (sap), mean arterial pressure (map) and diastolic arterial pressure (dap) from an invasive blood pressure source and a noninvasive ...202032688102
molecular characterization and immunodiagnostics of dicrocoelium dendriticum species isolated from sheep of north-west himalayan region.despite its extensive presence among grazing ruminants, dicrocoeliosis, also known as 'small liver fluke' disease, is poorly known and often underestimated by researchers and practitioners in many countries. the accurate identification and prepatent diagnosis of dicrocoelium dendriticum infection is an essential prerequisite for its prevention and control. in the present study, the morphologically identified specimens isolated from the bile ducts of sheep (ovis aries) were validated through mole ...202032684172
predicting ewe body condition score using lifetime liveweight and liveweight change, and previous body condition score record.the body condition score (bcs) in sheep (ovis aries) is a widely used subjective measure of body condition. body condition score and liveweight have been reported to be statistically and often linearly related in ewes. therefore, it was hypothesized that current bcs could be accurately and indirectly predicted using a ewe's lifetime liveweight, liveweight change, and previous bcs record. ewes born between 2011 and 2012 (n = 11,798) were followed from 8 months to approximately 67 months of age in ...202032668688
phylogeography and phylogenetic evolution in tibetan sheep based on mt-cyb sequences.to date, molecular genetics and population studies in tibetan sheep (ovis aries) have been limited, and little is known about the phylogenetic evolution and phylogeography of tibetan sheep populations. the aim of the present research was to explore phylogeography and phylogenetic evolution of tibetan sheep populations, on the basis of mitochondrial dna (mtdna) gene mt-cyb (1140 base pairs). our dataset consisted of 641 mt-cyb sequences from the same amount of animals belonging to 15 populations ...202032664644
comprehensive rna-seq profiling of the lung transcriptome of bashbay sheep in response to experimental mycoplasma ovipneumoniae infection.the bashbay sheep (ovis aries), an indigenous breed of xinjiang, china, has many excellent characteristics. it is resistant to mycoplasma ovipneumoniae infection, the causative agent of mycoplasma ovipneumonia, a chronic respiratory disease that is harmful to the sheep industry. to date, knowledge regarding the mechanisms responsible for m. ovipneumoniae pathogenesis in scant. herein, we report the results of transcriptome profiling of lung tissues from bashbay sheep experimentally infected with ...202032639963
seaweed-eating sheep show that δ34 s evidence for marine diets can be fully masked by sea spray effects.stable sulfur isotope compositions (δ34 s values) are a useful marker of terrestrial (lower δ34 s) versus marine (higher δ34 s) diets. in coastal areas, 34 s-enriched sea spray can obscure these marine/terrestrial differences. we sought to establish whether δ34 s values of sea spray-affected terrestrial fauna can be distinguished from those of marine-feeding terrestrial fauna.202032559821
highly efficient synchronization of sheep skin fibroblasts at g2/m phase and isolation of sheep y chromosomes by flow cytometric sorting.at present, based on whole genome sequencing, sequences and genes annotation of the sheep (ovis aries) y chromosome are still absent. the isolation of y chromosomes followed by sequencing has been approved as an effective approach to analyze this complex chromosome in other species. in this study, we established a highly efficient synchronization method for g2/m phase of sheep fibroblasts, which was successfully applied to flow-sorting chromosomes of sheep, with a focus on isolation and sequenci ...202032555328
dietary supplementation of sargassum latifolium modulates thermo-respiratory response, inflammation, and oxidative stress in bacterial endotoxin-challenged male barki sheep.endotoxemia is mainly caused by translocation of bacterial lipopolysaccharides (lps) into the bloodstream. this in turn enhances systemic inflammation and inappropriate production of reactive oxygen species, leading to oxidative injury of vital internal organs and other dangerous effects that can be life-threatening. here, we evaluated/compared the modulatory effects of consuming two different doses (2% and 4% of the diet) of brown seaweeds (sargassum latifolium) for 40 consecutive days on therm ...202032533495
a stop-gain mutation within mlph is responsible for the lilac dilution observed in jacob sheep.a coat color dilution, called lilac, was observed within the jacob sheep breed. this dilution results in sheep appearing gray, where black would normally occur. pedigree analysis suggested an autosomal recessive inheritance. whole-genome sequencing of a dilute case, a known carrier, and sixteen non-dilute sheep was used to identify the molecular variant responsible for the coat color change. through investigation of the genes mlph, myo5a, and rab27a, we discovered a nonsynonymous mutation within ...202032512769
importance of naturalized breeds as a base for the formation of exotic sheep (ovis aries) breeds in tropical altitude regions.recent molecular tools and technologies have marked the discovery of the origin and domestication processes of a wide variety of species, using either genomic or mitochondrial molecular markers to provide input for selection programs, as well as the management and conservation of animal breeds. this study aimed to analyze genes of mitochondrial dna of the following sheep (ovis aries) breeds: pantaneira, bergamácia, dorper, white dorper, ile de france and hampshire down, to obtain their populatio ...202032502229
whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits.understanding the genetic changes underlying phenotypic variation in sheep (ovis aries) may facilitate our efforts towards further improvement. here, we report the deep resequencing of 248 sheep including the wild ancestor (o. orientalis), landraces, and improved breeds. we explored the sheep variome and selection signatures. we detected genomic regions harboring genes associated with distinct morphological and agronomic traits, which may be past and potential future targets of domestication, br ...202032499537
a macroscopic comparison study on main branches of arteria brachialis and arteria subscapularis in southern karaman and hasak sheep breeds.the southern karaman sheep, which is very fertile in terms of meat and milk production and is often preferred in livestock raising, is known as a domestic sheep breed. the hasak sheep is a breed formed by the triple crossbreeding of the german black-headed, hampshire and akkaraman breeds. arterial feeding of the forelimb is provided by arteria axillaris, a continuation of arteria subclavia. in this study, it was aimed to examine the forelimb arteries in southern karaman and hasak sheep breeds. t ...202032488858
on the origin of european sheep as revealed by the diversity of the balkan breeds and by optimizing population-genetic analysis tools.in the neolithic, domestic sheep migrated into europe and subsequently spread in westerly and northwesterly directions. reconstruction of these migrations and subsequent genetic events requires a more detailed characterization of the current phylogeographic differentiation.202032408891
the impact of rumen-protected amino acids on the expression of key- genes involved in the innate immunity of dairy sheep.rumen protected amino acids inclusion in ewes' diets has been proposed to enhance their innate immunity. the objective of this work was to determine the impact of dietary supplementation with rumen-protected methionine or lysine, as well as with a combination of these amino acids in two different ratios, on the expression of selected key-genes (nlrs, myd88, trif, mapk-1, irf-3, jund, traf-3, irf-5, il-1α, il-10, ikk-α, stat-3 and ho-1). thus, sixty chios dairy ewes (ovis aries) were assigned to ...202032407360
an integrative bioinformatics analysis of caprine gnai3 gene.goat is the most preferred domesticated animal in indian subcontinent. however, the climatic change-induced heat stresscauses a formidable challenge for maintaining optimum productivity. g protein subunit alpha i3 (gnai3) is one of the genes that may have significant role in heat tolerance mechanism in goats. the caprine gnai3 gene was searched for homology analysis and its three dimensional protein structure was predicted followed by its validation through in silico approach. nucleotide sequenc ...202032366735
genomic diversity, population structure, and signature of selection in five chinese native sheep breeds adapted to extreme environments.through long term natural and artificial selection, domestic sheep (ovis aries) have become adapted to a diverse range of agro-ecological environments and display multiple phenotypic traits. characterization of diversity and selection signature is essential for genetic improvement, understanding of environmental adaptation, as well as utilization and conservation of sheep genetic resources. here, we aimed to assess genomic diversity, population structure, and genomic selection among five chinese ...202032365888
dietary supplementation of brown seaweed (sargassum latifolium) alleviates the environmental heat stress-induced toxicity in male barki sheep (ovis aries).heat stress (hs) is the most potent environmental stressors for livestock in tropical and subtropical regions. hs induced splanchnic tissue hypoxia and intestinal oxidative damage, leading to endotoxemia and systemic inflammation. the present study evaluated and compared the modulatory effects of feeding barki male sheep (ovis aries) on a standard concentrated diet containing 2% or 4% of the brown seaweed (sargassum latifolium) followed by roughage for 40 consecutive days on the toxicity-induced ...202032364993
expression and distribution of bone morphogenetic protein 4 and its antagonist noggin in the skin of kazakh sheep (ovis aries) with a white and brown coat color.the natural coat color is an important trait of vertebrate animals. for example, the coat color can help avoid harm to human beings caused by chemical dyeing, and it has economic significance for domestic animals. the bone morphogenetic protein 4 (bmp4) and its antagonist noggin can regulate pigmentation and the generation of coat color in mice; thus, they may also regulate the coat color of kazakh sheep. to gain mechanistic insight into this possibility, we determined the relative expression le ...202032331775
confirmation of a wear-compensation mechanism in dental roots of ruminants.diet affects many factors of an animal's anatomy, but teeth are a specific focus of dietary research, as their durability lends them to record information on a large variety of scales. abrasive diets like those of grazing herbivores are known to wear down teeth, but how that wear affects tooth growth and the relations between its different morphological components is rarely investigated. seven pelleted diets varying in abrasive size and concentration were fed over a 17-month period to 49 sheep ( ...202032314555
gene expression profiling of corpus luteum reveals important insights about early pregnancy in domestic sheep.the majority of pregnancy loss in ruminants occurs during the preimplantation stage, which is thus the most critical period determining reproductive success. here, we performed a comparative transcriptome study by sequencing total mrna from corpus luteum (cl) collected during the preimplantation stage of pregnancy in finnsheep, texel and f1 crosses. a total of 21,287 genes were expressed in our data. highly expressed autosomal genes in the cl were associated with biological processes such as pro ...202032290341
comparing the diversity of the casein genes in the asian mouflon and domestic sheep.we aimed to determine whether casein variants that are currently segregating in ovine populations existed before the domestication of sheep or, to the contrary, if their emergence is much more recent. to this end, we have retrieved whole-genome sequences from iranian and domestic sheep from africa, europe, south and east asia and west asia. population structure analysis based on 55,352,935 snps revealed a clear separation between iranian mouflons and domestic sheep. moreover, we also observed a ...202032281138
oesophageal sarcocystosis observed at slaughter provides a reliable and efficient proximate measure of toxoplasma gondii seroprevalence in sheep.successful disease management requires effective surveillance. slaughterhouse inspections provide opportunities to efficiently collect regular disease data from many animals across large areas. toxoplasma is a cat-borne parasite that causes reproduction failure in sheep, although it is not visually detectable at slaughterhouses. macroscopic sarcocystosis is a disease of sheep that is visually detectable at slaughter and is caused by parasites that share a similar biology with toxoplasma. we inve ...202032253762
identification of ancestry informative marker (aim) panels to assess hybridisation between feral and domestic sheep.hybridisation of wild populations with their domestic counterparts can lead to the loss of wildtype genetic integrity, outbreeding depression, and loss of adaptive features. the mediterranean island of sardinia hosts one of the last extant autochthonous european mouflon (ovis aries musimon) populations. although conservation policies, including reintroduction plans, have been enforced to preserve sardinian mouflon, crossbreeding with domestic sheep has been documented. we identified panels of si ...202032235592
characterization of a novel interleukin-1 receptor antagonist from sheep (ovis aries).interleukin-1 receptor antagonist (il-1ra) is an antagonist of il-1β binding il-1β receptors but does not induce intracellular responses or signal transduction. in this study, the full-length complementary dna (cdna) of the il-1ra gene (oail-1ra) was identified from sheep (ovis aries) using rapid amplification of cdna ends pcr and submitted to genbank with the accession number kc425613. the oail-1ra cdna comprised an open reading frame of 525 bp encoding a protein of 19765.8 da, a 5'-untranslate ...202032233931
contrasting patterns of sexually selected traits in mediterranean and continental populations of european mouflon.the expression of sexually selected traits in highly dimorphic ungulates may be influenced by environmental quality. variations in habitat conditions can impose different constraints on the allocation of energy resources to male life-history traits, and possibly alter the female preferences for specific features. here, we compared the horn growth patterns in male european mouflon ovis aries musimon living in different habitats (mediterranean vs. continental) but sharing a common genetic origin. ...202032128140
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