Publications

histopathological features of unilateral stapling in animal experiments.	blount stapling of the proximal medial tibial growth was performed in 10-week-old domestic pigs. a total of 37 animals for up to 17 weeks were followed up. the histological evaluation showed a different reaction of the growth plate in the medial (stapled), central and lateral area. up to 6 days after stapling the morphological features were characterized by deviations of the cell column from the axial alignment. herniations of mature chondrocytes as well as isles of epiphyseal cartilage splinter ...	1989	2619521
effects of fluoride on cortical bone remodeling in the growing domestic pig.	the purpose of the experiment was to assess the effects of fluoride (f-) on the remodeling process of cortical bone. sixteen pigs, eight experimental animals receiving a supplement of 2 mg f-/kg b.w. and eight controls, were studied in individual sites from age 8 to 14 months. at slaughter samples of cortical bone were obtained from the right femur and embedded undecalcified. a new stereologic model based on fluorochrome tissue time markers and isotropic uniform random histologic sections was im ...	1989	2624822
evidence from immunoblotting studies on uncoupling protein that brown adipose tissue is not present in the domestic pig.	adipose tissues and other tissues of the pig have been examined for the presence of the mitochondrial "uncoupling protein," characteristic of brown adipose tissue, in order to assess whether brown fat is present in this species. mitochondria were prepared from various tissues and the proteins separated on the basis of molecular weight by sodium dodecyl sulphate--polyacrylamide gel electrophoresis. immunoblotting procedures were then used to probe for uncoupling protein, employing a rabbit anti-( ...	1989	2627687
[morphometric study of bone in domestic pigs with fluorosis caused by coal-burning pollution].	forty four domestic pigs were divided into 2 groups: control group: 17 pigs; fluorosis group: 27. they were fed for 14 months in the endemic area or non-endemic area respectively. in some of the pigs, double tetracycline was given for bone dynamic study, and blood and urine were collected for biochemical analyses. iliac, tibia, fibula, the 2nd metatarsal and the 2nd vertebrae were reserved either for bone density measurement or for bone histomorphometric study. the results showed that fluoride c ...	1989	2630015
the high resolution r-banded karyotype of sus scrofa domestica l.		1990	2133260
brain oedema and intracranial pressure in superior sagittal sinus balloon occlusion. an experimental study in pigs.	about 2/3 of all patients with thrombosis of the superior sagittal sinus (sss) develop signs of increased icp and/or brain oedema (be). the time of onset and the spectrum of symptoms in sss thrombosis vary extremely. this variability might be caused by differences in pathomechanism like be and rise of icp, parameters studied in the present contribution. 10 domestic pigs received a standardized occlusion of the sss with two different balloon types (spherical and cylindrical). they were monitored ...	1990	2089903
in vivo evaluation of simultaneous administration of incompatible drugs via a double-lumen peripheral catheter.	for the critically ill patient with complex and prolonged needs, multiple drug infusions and, when indicated, peripheral hyperalimentation require simultaneous administration through a simple peripheral catheter site with a multilumen catheter. we studied a double-lumen peripheral venous catheter. ten domestic swine, 10 to 20 kg, were divided into two groups of five each. total parenteral nutrition was administered through the distal port and phenytoin was administered as a bolus and as an infus ...	1990	2119936
brief report: experimental hepatitis e infection in domestic pigs.		1990	2122999
the role of alpha 1-adrenoceptors in adrenaline-induced hyperkalaemia.	the hyperkalaemic action of adrenaline was investigated in 44 anaesthetized domestic pigs. plasma and epicardial concentrations of k+ were measured, in the latter case with an ion-selective electrode. adrenaline 10 micrograms kg-1 caused a rapid increase in the plasma concentration of k+ from 4.2 to 5.9 mmol litre-1. the magnitude and the time course of epicardial concentration of k+ were similar. alpha-adrenoceptor block with either phentolamine 5 mg kg-1 (non-selective block) or prazosin 0.1 m ...	1990	1979911
[animal experiments for testing the behavior of compacted bone sections using compression osteosynthesis after hyperthermic denaturation].	in animal experiments on domestic pigs the behaviour of hyperthermically denatured autogenic compact bone grafts after orthotopic replantation was investigated histologically. it was shown that the inductive osteogenetic celldifferentiation of the lair tissue caused by the autogenetic osteoimplantation depends on the location relationship of the replanted bone grafts to the lair bone tissue. this differentiation had progressed after 14 and 21 days further in the upper indifference area than in t ...	1990	2095646
recruitment of mononuclear cells by endothelial cell binding into wounded skin is a selective, time-dependent process with defined molecular interactions.	wound healing involves a complex series of interactions between cells in the dermis and epidermis, and important relationships exist between keratinocytes and resident dermal cells. monocytes and lymphocytes secrete cytokines that are capable of stimulating dermal repair and influencing keratinocyte and fibroblast migration and proliferation, although the mechanism by which mononuclear cells are recruited into the wound is unknown. we have tested the hypothesis that in wounded skin specialized e ...	1990	2212726
coronary reactivity in the porcine heart after short lasting myocardial ischaemia: effects of duration of ischaemia and myocardial stunning.	the aim was to characterise reactive hyperaemia and endothelium dependent (adp) and independent (adenosine) vasodilatation after ischaemic periods of increasing duration, and in the stunned myocardium.	1990	2097067
the purification and characterization of a fatty acid binding protein specific to pig (sus domesticus) adipose tissue.	western-blot analysis using antiserum to 3t3-l1-cell fatty acid binding protein (fabp) revealed that pig adipose tissue contains a 15 kda protein immunologically similar to the murine protein. this 15 kda protein was purified from pig adipose tissue by sequential application of sephadex g-50 gel filtration, cation exchange and covalent chromatography on thiol-sepharose-4b. the purity of the pig protein was established by two-dimensional polyacrylamide-gel electrophoresis. isoelectric focusing in ...	1990	2334399
rapid ventricular pacing in pigs: an experimental model of congestive heart failure.	to develop an improved animal model of congestive heart failure, 11 female farm pigs (wt, 42-46 kg) underwent rapid ventricular pacing at 230 beats/min for 7 days with a modified medtronic unipolar pacemaker connected to an apical pacing lead. after 7 days the pacemaker was turned off, anesthesia induced, the chest opened, and cardiac hemodynamic and dimensional studies were performed. results were subsequently compared with data from 12 control pigs that received no pacing. two pigs died before ...	1990	2337189
electrocardiographic effects of experimental myocardial infarction in pigs.	myocardial infarctions were produced in young domestic farm pigs by ligating coronary arteries. arteries ligated in four groups were (a) left anterior descending, (b) branches of left anterior descending, (c) left circumflex, and (d) right coronary artery. after 7 or 8 days, the hearts were removed and dissected and the infarcted areas measured. vectorcardiograms were taken before ligation and just before termination. high recording speeds and sensitivities were used so that details of the qrs c ...	1990	2341815
[light and electron microscopic studies of the histopathogenicity of macracanthorhynchus hirudinaceus (archiacanthocephala) in experimentally infected domestic swine].	one and 12 weeks after infection the lesions in the small intestine of two domestic pigs caused by macracanthorhynchus hirudinaceus were studied by means of light and electron microscopy. worms of 7 d.p.i. were found to have penetrated with their presoma into the tunica propria and partly into the tunica muscularis where they had caused local mechanic destructions and heavy eosinophilic-like and hemorrhagic reactions. most eosinophilic-like granulocytes were attracted to the proboscis hooks, at ...	1990	2336449
neuronal and adrenal enkephalins and catecholamines in response to acute cns ischemia and reserpine in pig.	co-storage of enkephalins and catecholamines in coronary artery, mesenteric artery and vein, middle cerebral artery, vas deferens and adrenal medulla was studied in domestic pig (sus scrofa). responses to acute cns ischemia were correlated with time to peak plasma levels of central venous and adrenal vein outflow samples in controls, during reserpine treatment and after drug withdrawal. endogenous enkephalins are co-stored in chromaffin granules of adrenal epinephrine-type cells and large dense ...	1990	2348053
[the effect of large-faced cerebral meningeal fibroses on the development of hemispheric volume. experimental and morphometric studies of swine brains].	alterations that occurred to the hemispheric structure as a result of experimentally induced meningeal fibrosis are reported in this paper. the rinsing function of cerebrospinal fluid was unilaterally stopped in the subarachnoidal space of domestic pigs by means of a viscous medium which contained soluble fatty acid salts. the animals were sacrificed 35 or 95 d after the experiments. series of frontal sections of both cerebral hemispheres were planimetrically measured to establish differences be ...	1990	2356672
the physiology of adaptation to small bowel resection in the pig: an integrated study of morphological and functional changes.	this study examined the adaptive response to extensive small intestinal resection in the juvenile domestic pig. control animals underwent an ileal transection with end-to-end anastomosis, whereas resected pigs had a resection of the mid-75% of the total small bowel length. animals were followed for 16 weeks. resected animals gained less weight than controls, with no significant difference in feed intake per unit animal weight. in vivo fat, protein, carbohydrate, and total energy absorption were ...	1990	2359003
measurement of mean circulatory filling pressure and vascular compliance in domestic pigs.	to measure mean circulatory filling pressure (pmcf), a balloon was placed in the right atrium of seven pentobarbital sodium-anesthetized open-chest pigs for transient occlusion of flow combined with mechanical transfer of blood from the arterial to the venous circulation. equilibration occurred within 6-8 s at a pressure at 12.3 +/- 0.3 (se) mmhg after a 2.9 +/- 0.2 ml/kg transfer of blood. in another group of pentobarbital sodium-anesthetized closed-chest pigs, acetylcholine (ach) was used to i ...	1990	2360680
[mortality by crushing in domestic pigs: study of the causes and their relationship to the time and the month of the year in the climatic conditions of cuba].	in the course of 3 years a complex of 25,000 pigs were investigated once per week for the dead among the 398 sucking piglets, and in the case of losses due to crushing to death the type of lesions and the connection with diseases was investigated. of the piglets investigated, 88 were crushed to death (21.2%), among them 65 (73.8%) diseased--mainly infected by coli bacilli (60 = 68.2%)--and 23 (5.8%) healthy animals. the losses due to crushing to death were highest in january and differed from al ...	1990	2360897
temporomandibular synovial fluid pressure response to altered mandibular positions.	hydrostatic synovial fluid pressure within the superior aspect of the temporomandibular joint space of the growing pig, sus scrofa domesticus, was examined in response to various acute and chronic alterations of mandibular position. bilateral measurements of pressure were recorded with chronically implanted wick catheters in three 8-week-old pigs before and at the time of appliance placement and then at 2-day intervals until the animals were 20 weeks old. besides confirming the observations of a ...	1990	2363402
cholinergic regulation of resting coronary blood flow in domestic swine.	cholinergic vasoconstriction in vivo and the influence of resting cholinergic activity on basal coronary tone were investigated by measuring coronary blood flow, cardiac function, and blood gases during either acetylcholine injection, muscarinic receptor blockade, or vagal ligation, in open-chest chloralose-urethan-anesthetized swine. intracoronary injections of acetylcholine (0.5-3.0 micrograms) caused significant (p less than 0.05) dose-dependent reductions in coronary blood flow (19.0-75.5%) ...	1990	2375397
volumetric comparison of auditory structures in the brains of european wild boars (sus scrofa) and domestic pigs (sus scrofa f. dom.).	the size of certain brain parts involved in the processing of auditory stimuli was measured in european wild boars (sus scrofa) and domestic pigs (sus scrofa f. dom.). by means of intraspecific allometric methods for analyzing the brain weight to body weight relationships, the volumes were compared in both groups. in general, all measured structures were smaller in the domestic form, indicating that domestication has led to a decrease in the size of auditory brain parts. within the auditory syst ...	1990	2375973
immunocytochemical demonstration of the calcium-binding proteins calbindin-d 28k and parvalbumin in the subiculum, hippocampus and dentate area of the domestic pig.	the distribution of the calcium-binding proteins calbindin-d 28k (cabp) and parvalbumin (pv) in the hippocampal region of the domestic pig was demonstrated by immunocytochemistry. scattered cabp-immunoreactive cell bodies were present in the subiculum, stratum oriens, pyramidal cell layer and stratum radiatum of the hippocampal regio superior and inferior, and the outer plexiform layer and outer hilar cell layer of the dentate hilus. other cell bodies and bundles of stained fibers were present i ...	1990	2392572
intravenous midazolam suppression of pentylenetetrazol-induced epileptogenic activity in a porcine model.	generalized tonic-clonic seizures are a neurologic emergency. duration of ictal activity has been associated with neurologic sequelae. the purpose of this study was to determine if midazolam, a short-acting benzodiazepine, could effectively ablate ictal activity in an animal model without significant cardiorespiratory compromise. ten domestic swine (10 to 20 kg) were ventilated and hemodynamically monitored. bifrontal craniotomies were performed and electrocortical activity was recorded througho ...	1990	2105874
[cytoarchitecture and topography of the ventromedial hypothalamic nuclei of swine (sus scrofa domestica)].	the topography and cytoarchitecture of nc. hypothalamicus ventromedialis, nc. hypothalamicus dorsomedialis and nc. infundibularis were descripted in the pig. the nc. hypothalamicus ventromedialis is the dominant nucleus in the tuber cinereum. the rostral pole lies caudal to the nc. hypothalamicus anterior. its caudal pole is bounded by the nc. premamillaris and the nc. hypothalamicus ventrolateralis. scattered neurons separate the nc. hypothalamicus ventromedialis dorsal from the nc. hypothalami ...	1990	1707075
pronounced accumulation of metoprolol in ischemic myocardium after coronary venous retroinfusion.	the myocardial availability of the beta 1-selective blocker metoprolol was compared following standard intravenous (i.v.) administration and after coronary venous retroinfusion. thirteen open-chest farm pigs were subjected to 90-min occlusion of the left anterior descending coronary artery. in six of these pigs, metoprolol was administered as an i.v. injection while 7 pigs received the drug retrogradely into the coronary vein. the time of administration was 5 min. in both groups, metoprolol was ...	1990	1688978
increases in coronary vein co2 during cardiac resuscitation.	we investigated the aortic, mixed venous, and great cardiac vein acid-base changes in eight domestic pigs during cardiac arrest produced by ventricular fibrillation and during cardiopulmonary resuscitation (cpr). the great cardiac vein pco2 increased from a control value of 52 +/- 2 to 132 +/- 28 (sd) torr during cpr, whereas the arterial pco2 was unchanged (39 +/- 4 vs. 38 +/- 4). the coronary venoarterial pco2 gradient, therefore, increased remarkably from 13 +/- 2 to 94 +/- 29 torr. the simul ...	1990	2112125
protective effects of nipradilol, isosorbide dinitrate, and bunazosin on coronary artery constriction induced by intracoronary injection of acetylcholine in pigs.	protective effects of nipradilol, a newly synthesised vasodilating beta adrenoceptor antagonist, isosorbide dinitrate, and bunazosin on coronary artery constriction induced by intracoronary injection of acetylcholine were determined by coronary arteriography and compared in vivo in pigs.	1990	1982930
[histotopographic studies of the intramural coronary arteries in the trabecula septomarginalis of the right cardiac ventricle in swine (sus scrofa domesticus) and dwarf goats (capra aegagrus f. domestica)].	in the trabecula septomarginalis (moderator band) of pig and pygmy goat regularly till to 6 arteries are found, which traverse from the interventricular septum to the m. papillarius magnus. these intramural coronary arteries (diameter 50-300 microns)--without any exception-musculoelastic intimal thickenings are recognizable, which often marked extensive and formed in the whole vessel length. it is concluded that coronary arteries enlarge in response to increasing intimal thickening and that such ...	1990	2077762
[determinants of survival in cardiopulmonary resuscitation].	prognostic indices for survival after cardiopulmonary resuscitation (cpr) were investigated in 14 male sprague-dawley rats (500 +/- 50 g) and in 16 domestic pigs (25 +/- 4 kg). arterial and venous blood gas and lactate measurements in association with the coronary perfusion pressure (cpp) and the end-expiratory co2 concentration (etco2) were evaluated. additional parameters in the porcine studies were coronary venous blood gas measurements and intramyocardial ph. volume controlled ventilation wa ...	1990	2112683
opioid control of growth hormone in the suckled sow is primarily mediated through growth hormone releasing factor.	endogenous opioid peptides mediate the effect of suckling on lh and prl in the domestic pig. however, the role of opioids in modulating gh during lactation in swine is not known. primiparous sows that had been immunized against grf(1-29) conjugated to human serum albumin (grf-hsa, n = 5) or hsa (n = 4) were used to determine changes in gh after naloxone. treatments were imposed in all sows on day 21 of lactation when antibody titers were 9100 +/- 1629. all sows received (i.v.) naloxone (0.25 mg/ ...	1990	2114957
mono-hydroxyeicosatetraenoic acids during porcine endotoxemia. effect of a platelet-activating factor receptor antagonist.	infusion of endotoxin into domestic pigs induces an acute respiratory failure that has many similarities with the adult respiratory distress syndrome. we hypothesized that mono-hydroxyeicosatetraenoic acids (hete) and platelet-activating factor (paf) might be involved in this model of respiratory failure. escherichia coli endotoxin (055-b5) was infused intravenously into anesthetized young pigs at 5 micrograms/kg the first hour, followed by 2 micrograms/kg/hour for 3 hours in the presence and ab ...	1990	2116563
assignment of nucleoside phosphorylase gene to q2.1----q2.2 region of chromosome 7 in the pig, sus scrofa domestica l.	using in situ hybridization with a human probe, we have mapped the nucleoside phosphorylase gene on pig chromosome 7. these results are in agreement with those obtained by other groups, but give a more precise localization in the q2.1----q2.2 region of chromosome 7.	1990	2117408
morphology of normal and osteochondrotic porcine articular-epiphyseal cartilage. a study in the domestic pig and minipig of wild hog ancestry.	osteochondrosis is a generalized skeletal disorder that affects the growth cartilage in the growing domestic pig but not in the minipig of wild hog ancestry. in the present study, we compare the ultrastructure of the articular and epiphyseal growth cartilage in the domestic pig with that in the minipig. the domestic pigs had areas of enlarged epiphyseal cartilage with chondronecrosis, which had caused focal impairment of the endochondral ossification, with retention of cartilage in the subchondr ...	1990	2077805
recovery after cold cardioplegic arrest of isolated blood-perfused hearts excised from non-anesthetized pigs.	an isolated blood-perfused pig heart model has been established in order to evaluate the recovery of hearts obtained from slaughterhouse domestic pigs avoiding anesthesia and direct experiments on animals. eleven hearts subjected to 9 min of normothermic ischemia were infused with cold modified bretschneider solution. after 180 min of cardioplegic-induced global ischemia (including 9 min of normothermic ischemia) 8 hearts were reperfused for 120 min. left ventricular function (measured isovolume ...	1990	2079092
localization of atrial natriuretic peptide/cardiodilatin (anp/cdd)-immunoreactivity in the lacrimal gland of the domestic pig.	the presence of atrial natriuretic peptic/cardiodilatin-immunoreactive material was demonstrated in the lacrimal gland of the domestic pig by high performance liquid chromatography and radioimmunoassay. the immunohistochemical localization revealed a distinct population of cuboid or spindle-shaped anp/cdd-ir cells in the epithelium of the terminal portion of the secretory tubules. in addition, a moderate number of positive cells was localized intraepithelially in the intralobular ducts as well a ...	1990	2138565
occlusive dressings. does dressing type influence the growth of common bacterial pathogens?	we studied the effect of different occlusive dressings and of air exposure on the growth of four pathogenic bacteria in wounds. partial-thickness wounds on domestic pigs were inoculated with staphylococcus aureus, clostridium perfringens, bacteroides fragilis, or pseudomonas aeruginosa. each wound was covered with three dressings (duoderm, opsite, or vigilon), or left exposed to air. groups of wounds were sampled at 24, 48, and 72 hours. staphylococcus aureus reached high levels beneath all of t ...	1990	2119166
[immunogenetic characteristics of the gene fund of kakhetian swine and dynamics of population parameters in several generations].	some peculiarities of gene fund and dynamics of populational characters of the oldest in europe kakhetian (georgian) pigs were investigated during 18 years (10 generations). genetic peculiarity of the aboriginal species populations in conditions of intensive pressure of natural selection and relatively weak artificial selection was determined with the help of codominant alleles of the blood groups e system. considerable qualitative and quantitative differences were detected between kakhetian pig ...	1990	2146185
simulated left ventricular aneurysm and aneurysm repair in swine.	patch reconstruction of left ventricular aneurysm may be superior to linear closure, but this hypothesis has not been tested experimentally. accordingly, six anesthetized domestic pigs were instrumented to measure regional left ventricular wall thickening, stroke volume, systolic left ventricular pressure, and myocardial oxygen consumption. with total bypass and cardioplegia, a 6 by 8 cm dacron patch was inserted into the anteroapical left ventricle. simulations were as follows: left ventricular ...	1990	2146447
restenosis after balloon angioplasty. a practical proliferative model in porcine coronary arteries.	a model of proliferative human restenosis was developed in domestic pigs by using deep injury to the coronary arterial media. metal wire coils were delivered percutaneously to the coronary arteries of 11 pigs with an oversized, high-pressure (14 atm) balloon and were left in place for times ranging from 28 to 70 days. during placement, the balloon expanded the coils and delivered them securely within the arterial lumen. light microscopic examination of the vessels confirmed fracture of the inter ...	1990	2146991
detection of aujeszky's disease virus in nasal cells of fattening pigs by immunoassay.	both conventional and specific pathogen free pigs were inoculated intranasally with a strain of aujeszky's disease virus (adv). nasal cells were collected daily by swab, aspiration or wash. the nasal cells were examined for adv by isolation on cell culture, direct or indirect immunofluorescence and immunoperoxidase staining by monoclonal antibodies. the infected pigs were studied for nasal shedding of infected cells until 30 days after infection. the study was also extended to naturally infected ...	1990	2154020
serologic survey for transmissible gastroenteritis virus neutralizing antibodies in selected feral and domestic swine sera in the southern united states.	serum samples collected from feral and domestic swine (sus scrofa) in florida and feral swine in georgia and texas were assayed by plaque reduction for their virus neutralizing (vn) antibodies against the porcine transmissible gastroenteritis virus (tge). none of 560 samples collected from feral swine contained vn antibodies for tge virus, but experimentally infected feral swine seroconverted. none of 665 samples from domestic swine contained tge-vn antibodies. these results indicate feral swine ...	1990	2167395
fasting energy metabolism of the yucatan miniature pig.	the fasting metabolic rates (fmr) of yucatan miniature swine were determined using an open-circuit indirect respiration calorimeter. mature nulliparous females had a mean fmr of 93 kcal/kg bw.75 and did not change significantly during the estrous cycle. this value is comparable to that observed in mature domestic swine. the calculated metabolizable energy requirement for maintenance for the yucatan sow is 116 kcal/kg bw.75. growing yucatan boars had fmr of 127, 119 and 101 kcal/kg bw.75 at 15, 2 ...	1990	2157095
normal physiological values for conscious pigs used in biomedical research.	although the domestic pig is rapidly becoming an animal of choice in certain areas of biomedical research requiring a large animal model, effective utilization of the species is often encumbered by a lack of reference values for common functional variables. to address this problem, normal data for over 100 physiologic or related variables were collected from conscious chronically instrumented animals that were maintained under near basal conditions. included were measurements of body composition ...	1990	2162986
neuromuscular transmission in the gastrocnemius muscle of young domestic and wild pigs.	the gastrocnemius muscle was stimulated in situ in young female domestic pigs (dp, sus scrofa domestica, german landrace; n = 24) and in european wild pigs (wp, sus scrofa scrofa; n = 20), by short (0.1 ms) square-wave impulses via the sciatic nerve. evoked compound action potentials were recorded from the sciatic nerve, from the ramus muscularis distalis of the tibial nerve and from the end plate region of the muscle tissue. maximum nerve conduction velocities (ncv) were 58.8 +/- 10.4 m/s in dp ...	1990	2168115
c-band fusion and behaviour of the involved chromosomes during meiotic prophase i of the male domestic pig.	behaviour of acrocentric chromosome synaptonemal complexes (scs) and constitutive heterochromatin (c-band) during meiotic prophase i of the male domestic pig was studied using surface spreading and silver staining techniques. at late zygotene c-band regions of complete or incomplete scs of the acrocentric chromosomes are represented by enlarged structures. at the same time these structures commenced fusion, which is accomplished at pachytene. using kinetochores and nors as markers, the pachytene ...	1990	2211180
maintenance and differentiation in culture of pluripotential embryonic cell lines from pig blastocysts.	cell lines were established from explanted blastocysts of domestic pigs; the cells could be maintained indefinitely when grown on mouse fibroblast feeder cell layers. they differentiate spontaneously at high densities, or when allowed to form aggregates when cultured on a non-adhesive substratum. their appearance and differentiative behaviour resembles that of mouse embryonic stem cell lines. we are currently attempting to establish whether these cultures represent primary ectodermal lineages wh ...	1990	2213715
responses of harbor seal and pig heart to progressive and acute hypoxia.	myocardial oxidative and glycolytic reserves were evaluated in four harbor seals, phoca vitulina richardsi, and six domestic pigs, sus scrofa (hematocrits: 58 +/- 5 and 34 +/- 1%., respectively). progressive hypoxia was induced by lowering arterial hemoglobin-oxygen saturation in 10% decrements, each maintained for 10-min periods, until the onset of heart failure. myocardial oxygen consumption rate (vo2), lactate release/uptake rate (l), and triple product, an index of myocardial energetic deman ...	1990	2221153
nisoldipine inhibits lipid peroxidation induced by coronary occlusion in pig myocardium.	the aim was to investigate the effect of the ca++ channel blocker nisoldipine on the content of lipid peroxidation products in pig myocardium after acute coronary occlusion.	1990	2224937
protective effect of verapamil in ischemic porcine hearts: analysis of ultrastructural and metabolic changes using in vivo 31p-nmr spectroscopy.	to assess the protective effect of verapamil on ischemic myocardium, the changes in high energy phosphates, inorganic phosphate, and intracellular ph were serially and quantitatively measured in ischemic porcine hearts without collateral circulation using 31p-nmr spectroscopy, together with ultrastructural examination. twenty-six farm pigs weighing 11 to 14 kg were anesthetized with fluothane and were divided into control (c) group and verapamil pretreatment (v) group. in v group 0.2 mg/kg of ve ...	1990	2231744
importance of acid-base strategy in reducing myocardial and whole body oxygen consumption during perfusion hypothermia.	during induced hypothermia with cardiopulmonary bypass, acid-base management usually follows one of two strategies: the so-called ectothermic or alpha-stat strategy, in which the ph of the arterial blood increases 0.015 ph units for every degree celsius decrease in body temperature, or the ph-stat strategy, in which ph remains 7.4 at all temperatures. it has been assumed that oxygen consumption decreases approximately equally during hypothermia with either strategy, although there are biochemica ...	1990	2232832
quantum type bone remodeling in the otic capsule of the pig.	normal quantum type bone remodeling was studied in temporal bones of young domestic pigs by means of combined microradiography, osteofluorochrome labelling and osteoid staining. evolving secondary osteons were morphologically normal although much less in the otic capsule than in the surrounding compacta of the temporal bones or in long bones. moreover, remodeling was totally absent in bone tissue immediately adjacent to perilymphatic spaces suggesting the presence of a local mechanism controllin ...	1990	2239210
postnatal development of the hair cycle in the domestic pig.	the postnatal patterns of hair follicle activity have been quantified in pigs born in summer and winter. animals were skin sampled monthly during the first year of life and the stages of the hair cycle were identified from follicles in histological sections. percentages of active follicles were used to determine hair cycle patterns and as a measure of how the hair cycle became synchronised with that of the adult. at birth, in excess of 95% of follicles were active in fibre production. within the ...	1990	2254156
meiotic chromosome behaviour reflects levels of sequence divergence in sus scrofa domestica satellite dna.	we present a general model for the evolution of chromosome-specific satellite dna subfamilies. sus scrofa domestica has a bimodal karyotype with two autosomal subsets of 12 meta-/submetacentric (mc) and 6 acrocentric (ac) chromosome types (mc and ac "subgenomes"). we show that the centromeric heterochromatin is characterised by two distinct satellite dna families designed mc1 and ac2. mc1 is a diverse satellite family of the mc subgenome of which certain members with a 100 bp repeat unit are fou ...	1990	2265570
[expression of constitutive heterochromatin by alui restriction endonuclease treatment and ca3/da/dapi staining of domestic pig chromosome].	the heterogeneity of constitutive heterochromatin in two domestic pigs has been studied by restriction endonuclease alui banding, ca3/da/dapi banding and c-banding techniques. the results show that the centromere constitutive heterochromatin can be subdivided into three types, which located in different chromosomes. it is found that there is correspondence between no. 13--18 chromosomes in pigs and no. 1, 9, 16, y chromosome in human by comparing the banding patterns of alui and ca3/da/dapi. the ...	1990	2268447
hearing in domestic pigs (sus scrofa) and goats (capra hircus).	behavioral audiograms were determined for three pigs and two goats. the hearing of the pigs ranged from 42 hz to 40.5 khz with a region of best sensitivity from 250 hz to 16 khz. hearing in goats ranged from 78 hz to 37 khz with a well-defined point of best sensitivity at 2 khz. because these animals are unable to localize high-frequency tones, it seems unlikely that selective pressure to use the interaural spectral-difference cue for sound localization is behind their high-frequency hearing. in ...	1990	2272932
plasma concentrations of laudanosine, but not of atracurium, are increased during the anhepatic phase of orthotopic liver transplantation in pigs.	to quantify the changes in plasma concentrations of atracurium and laudanosine induced by the lack of hepatic function and circulation, the authors studied nine domestic pigs (22-25 kg) undergoing an orthotopic liver transplantation, and three control animals without surgery, using atracurium as the muscle relaxant. after intubation facilitated by isoflurane 2-3%, anesthesia was maintained with isoflurane (0.5% in oxygen) and fentanyl (4 micrograms.kg-1.hr-1). ventilation was controlled to keep ...	1990	2297117
postnatal developmental profile of 3-hydroxy-3-methylglutaryl-coa reductase, squalene synthetase and cholesterol 7 alpha-hydroxylase activities in the liver of domestic swine.	activities of 3-hydroxy-3-methylglutaryl-coa reductase, squalene synthetase and cholesterol 7 alpha-hydroxylase, measured in liver microsomal preparations from domestic swine between birth and adolescence, correlated strongly in individual animals. a synchronous increase was observed between 4 and 6 weeks after birth, i.e., immediately after weaning. rise in activity was highest for hmg-coa reductase (30-fold), and smallest for squalene synthetase (5-fold). in pubertal pigs (16 to 30 weeks old), ...	1990	2297519
atherosclerotic yucatan microswine: an animal model with high-grade, fibrocalcific, nonfatty lesions suitable for testing catheter-based interventions.	a new breed of swine, the yucatan microswine, that was derived from repetitive inbreeding of selected, small yucatan swine, was investigated as an animal model of advanced vascular atherosclerosis. nineteen animals were fed an atherogenic diet for 9.9 +/- 1.5 (mean +/- sem) weeks before and 19.9 +/- 1.8 weeks after balloon endothelial denudation of all four iliac arteries. in 18 (94.7%) of the 19 microswine, angiography performed at 33 to 87 weeks of age disclosed some degree of luminal diameter ...	1990	2301218
effects of physostigmine on the cardiopulmonary system of conscious pigs.	physostigmine, as a pretreatment candidate for nerve agent poisoning, was examined for cardiopulmonary side effects. cardiovascular and pulmonary parameters were monitored in unanesthetized domestic pigs which received pulmonary arterial infusion of 5 micrograms/kg/min physostigmine salicylate for 2 hr. a level of 74% inhibition of red blood cell (rbc) acetylcholinesterase (ache) activity was attained in 45 min, and this level of carbamylation increased only slightly during the remaining infusio ...	1990	2307326
second-degree burn healing: the effect of occlusive dressings and a cream.	because occlusive dressings and some creams have been found to speed epithelialization of blade-induced wounds, we studied the effect of two occlusive dressings and a polyglycerylmethacrylate cream containing low concentration of fibronectin on epithelialization in second-degree burn wounds. cylindrical brass rods were heated in a boiling water bath, removed, wiped dry, and placed (6 sec) on the skin of domestic pigs. the burned epidermis was removed and each burn wound was assigned to one of th ...	1990	2314098
cocaine hepatotoxicity in cultured liver slices: a species comparison.	studies were carried out in order to find a sensitive in vitro model with which to investigate cocaine-mediated hepatotoxicity. precision-cut liver slices were prepared from: human, domestic pig, new zealand white rabbit, sprague-dawley (s/d) rat, and two mouse strains (dba/2ha and icr). the rationale for the choice of these species was that information on in vivo effects of cocaine was available in the literature. slices were cultured for up to 6 h in the presence of 0-5 mm cocaine. indices of ...	1990	2321245
masseter muscle performance. significance of structure and metabolism. a morphological and experimental study.	the aim of this thesis was to characterize structural factors in masticatory systems relevant to functional evaluations and to elucidate the effect on energy metabolism of electrically induced jaw muscle fatigue. an omnivorous masticatory system (the domestic pig) was compared morphologically with a carnivorous (the dog). porcine masseter muscles were evaluated by atp-ase histochemistry as well as with nadh-dehydrogenase and pas-staining. contractional characteristics were obtained from the porc ...	1990	2326743
analysis of naturally occurring deletion variants of african swine fever virus: multigene family 110 is not essential for infectivity or virulence in pigs.	a comparison of uncloned african swine fever virus isolates with their cloned counterparts revealed the presence of genetic variants in three out of seven uncloned field virus populations tested. five different virus clones were isolated from the uncloned kir69 virus stock by limit dilution. structural analysis of the variants showed that they differed by single deletions of 10-16 kilobases in the region located between 6.8 and 27 kilobases from the left dna terminus. there was no homology betwe ...	1990	2330671
[crown wall thickness, external dimensions and solid pulp substance relationships of swine teeth].	investigations had been carried out with 60 premolars of the upper and lower jaws in 2-year old domestic pigs in relation to their crown dimensions, their layer thickness of enamel and dentine.	1990	2334060
an experimental technique for heart-lung transplantation in subprimate models.	the success of heart-lung transplant experiments in subprimate models has been limited because most techniques include total pulmonary denervation, which causes respiratory problems, blood loss, and subsequent death. using 20 subprimates (12 domestic swine and 8 mongrel dogs), we tested a heterotopic heart-single lung transplant method intended to preserve unilateral pulmonary innervation and to reduce blood loss. after native right pneumonectomy, the donor heart and right lung were transplanted ...	1990	15227176
new data on aberrant spermatozoa in the ejaculate of sus domesticus.	this paper describes 16 new types of aberrant spermatozoa observed by scanning electron microscopy in the ejaculate of two healthy, sexually mature landrace boars. the new anomalies observed were 1) spermatozoa with folded tail and abnormal head; 2) tailless spermatozoa with an abnormal connecting piece; 3) immature spermatozoa with two tails of the same length, fused and coiled; 4) spermatozoa with two tails of the same length, fused and coiled, and a small, rounded head; 5) spermatozoa with tw ...	1991	16726941
enhancement of re-epithelialization with topical zinc oxide in porcine partial-thickness wounds.	we investigated the effect of locally applied zinc on the healing of partial-thickness skin wounds in the domestic pig using two zinc compounds (zinc oxide and zinc sulfate) in two different vehicles (a gauze compress and a collagen sponge). the rate of re-epithelialization was determined morphometrically 48 and 64 hr after infliction of standardized square wounds (4.8 cm2 and 400-microns deep) with an electrokeratome. zinc oxide in gauze significantly (p less than 0.05) increased re-epitheliali ...	1991	1990212
[homology between the lpm system of allotypes in the american mink and the gp system of allotypes in the domestic pig].	the 5 alpha-macroglobulin allotypes alpha m1, alpha m2, alpha m3, alpha m4 and alpha m5 were identified in pig. the alpha m1 allotype was reported as a marker of pig alpha-macroglobulin, the latter being homologous to alpha 2-macroglobulins in human and in mink. the allotypes alpha m2-alpha m5 were specified as markers of the second isotypical variant of pig alpha-macroglobulins, which was homologous to mink lpm macroglobulin (alpha 1m). as seen from data obtained by international comparative te ...	1991	1714847
epidemiologic study and control of taenia solium infections with praziquantel in a rural village of mexico.	this study reports the results of an epidemiologic survey for the detection of taenia solium in a rural village of 559 inhabitants in sinaloa, mexico, as well as a large scale treatment of the population with praziquantel. the study was carried out in two stages. in stage 1, serial stool analysis of 392 persons detected a cluster of three t. solium tapeworms. a fourth t. solium tapeworm was detected through a household census, giving a 1.32% prevalence rate for this helminth. over 70% of the pop ...	1991	1951862
ischemic preconditioning preserves creatine phosphate and intracellular ph.	ischemic preconditioning slows atp depletion and ultrastructural damage during the final episode of ischemia. to define the influence of creatine phosphate (cp) and intracellular ph (phi) on this effect, cp and phi were serially measured in porcine hearts without collateral circulation by using 31p-nmr spectroscopy and ultrastructural examination.	1991	1959199
buffer solutions may compromise cardiac resuscitation by reducing coronary perfusion presssure.	--to investigate the effects of hypertonic buffer solutions on coronary perfusion pressure (cpp) and resuscitability during experimental closed-chest cardiac resuscitation.	1991	1920701
internal mammary artery use. sternal revascularization and experimental infection patterns.	we have described previously the acute sternal devascularization produced by mobilization of one or both internal mammary arteries (imas). the present experiments were conducted to examine the time course of sternal revascularization and infection patterns after ima use. twenty-four 8-week-old domestic pigs were obtained from a herd in which active streptococcus faecalis had been detected in recent litters. after control blood flow procedures (microspheres) were completed, each pig underwent a m ...	1991	1934421
electron microscopical demonstration of thiols and disulphides in the porcine epidermis.	this study describes the electron microscopical distribution of free thiols and disulphides in the epidermis of the domestic pig and the wild boar, as compared to light microscopical histochemistry. with the silver methenamine method, silver labelling of thiols was clearly achieved on the keratohyalin and cytofilament accumulations in the cells of the living epidermis and the plasma membrane of granular cells. to a certain extent, the envelope and cytoplasm of young corneocytes reacted equally i ...	1991	1743999
natural history of 'deep dermal' burns in domestic pigs.		1991	1760120
prevalence of sarcocystis in domestic pigs in india.	muscle samples from 890 slaughtered pigs were examined for the presence of sarcocysts. a high prevalence rate of 67.98% was observed. two types of microsarcocysts were recorded. the sarcocyst wall of one type had redial striations and the other possessed hair-like villar protrusions. the species were identified as sarcocystis miescheriana and sarcocystis suihominis; there was a slightly higher incidence of the latter species (47.11%) than of the former (43.14%). s. suihominis has been identified ...	1991	1763484
histochemical demonstration of zinc in the hippocampal region of the domestic pig: ii. subiculum and hippocampus.	the distribution of zinc has been described in two areas of the hippocampal region of the domestic pig, viz., the subiculum and the hippocampus. zinc was demonstrated histochemically according to the neo-timm method, a modification of the sulphide-silver procedure. in each of the examined areas the staining displayed a distinctly stratified pattern which has been compared in detail to fields and layers defined on the basis of cyto- and fibroarchitecture, resulting in a combined chemo- and cytoar ...	1991	1709650
distribution of substance p, gnrh, met-enkephalin in the central nervous system of the pig.	the distribution of substance p (sp), gonadotropin releasing hormone (gnrh) and met-enkephalin in the brain and spinal cord of the domestic pig is described for the first time. the levels of sp, gnrh and met-enkephalin were measured by specific radioimmunoassays in various regions of the brain and spinal cord of the pig. substance p and met-enkephalin are widely distributed within the central nervous system of the pig. high levels of sp were found in the preoptic area (poa), suprachiasmatic area ...	1991	1714337
[two novel reciprocal translocations involving chromosome 6 in the domestic pig].	in the present study 2 new reciprocal translocations are described in two hypoprolific boars. the first one, a gascon/meishan boar, has produced a mean value of 7.37 +/- 0.69 piglets, vs 12.41 +/- 0.22 piglets per litter in contemporaries. the second one, a pietrain/large-white boar, has produced a mean of 5.42 +/- 0.69 vs 12.41 +/- 0.22 piglets per litter in contemporaries. each of these animals carries a new chromosome translocation involving chromosomes 6, 8 and 15, respectively. the first tr ...	1991	1746885
effect of carcass size on rate of decomposition and arthropod succession patterns.	decomposition studies were conducted using two carcasses of domestic pigs, sus scrofa l., 8.4 kg and 15.1 kg in weight, to determine the effects of carcass size on the rate of decomposition, composition of the arthropod fauna, and succession patterns. a total of 46 arthropod taxa were recovered during this study. no size-related differences were observed between carcasses with respect to composition of the arthropod fauna or patterns of succession. a greater number of arthropods were observed at ...	1991	1750396
the porcine pgd gene is preferentially lost from chromosome 6 in pig x rodent somatic cell hybrids.	the 6-phosphogluconate dehydrogenase (pgd) and glucose phosphate isomerase (gpi) genes are both located on chromosome 6 in the pig (sus scrofa domestica). nonetheless, the pgd gene was absent in a total of 17 gpi-positive cell lines found in three independently derived panels of pig x rodent somatic cell hybrids. in most of these cell lines we found an apparently normal pig chromosome 6 at cytogenetic analysis. these results suggest instability of the porcine pgd gene region in interspecies hybr ...	1991	1774184
glucose 6-phosphate dehydrogenase: isoenzymatic pattern in oesophagostomum venulosum, trichuris ovis and t. suis.	in the present communication we have studied the isoenzymatic pattern activity of the glucose 6-phosphate dehydrogenase (g6pd) in oesophagostomum venulosum, trichuris ovis and t. suis, parasites of capra hircus (goat), ovis aries (sheep) and sus scrofa domestica (pig) respectively, by polyacrylamide gel electrophoresis. different phenotypes have been observed in the g6pd isoenzymatic pattern activity in males and females of oesophagostomum venulosum. furthermore, g6pd activity has been assayed i ...	1991	1795090
[the sensitive nerve endings of the clitoris of the sow (sus scrofa domesticus)].	neural receptors of the porcine clitoris were examined using light and electron microscopy. perfusion with ink allowed study of the unique vascular arrangement associated with the genital corpuscles. sensory nerve-endings were generally rounded and formed a morphologically and structurally characteristic unit. they were composed of a network of primarily non-myelinated nerve fibers and flat cells. between these structures, isolated small blood vessels were embedded amongst collagen fibers and am ...	1991	1796789
pharmacokinetic analysis of coronary sinus retroinfusion in pigs. ischemic myocardial concentrations in the left circumflex coronary arterial area using metoprolol as a tracer.	myocardial availability of drug, using metoprolol as a tracer, in acutely ischemic myocardium in the area of the left circumflex (lcx) coronary artery was compared following standard intravenous (iv) administration and after coronary sinus retroinfusion. seven open-chest farm pigs were subjected to a 21-minute occlusion of the lcx coronary artery. all animals received simultaneous iv tritium-labeled metoprolol (0.2 mg/kg) and unlabeled metoprolol (0.2 mg/kg) retrogradely into the coronary sinus. ...	1991	1801888
anatomy and function of the cruciate ligaments of the domestic pig (sus scrofa domestica): a comparison with human cruciates.	pig cruciate ligaments were dissected and examined radiologically to evaluate their function. the variations in distance between the origin and insertion of the fibre bundles were measured in different joint positions; the maximal decrease in distance amounted to 50% in the anterior (acl) and 30% in the posterior cruciate ligament (pcl). the acl consists of 2 morphologically distinct portions. most of its fibres are found to be taut in extension. its posterolateral portion contains a 'guiding bu ...	1991	1810918
normal anatomy of the aqueous humour outflow system in the domestic pig eye.	the normal functional anatomy of the aqueous humour outflow pathways in the domestic pig is poorly documented in the literature despite its being readily available and of a similar size to the human eye. anterior segment tissue from 12 pig eyes was appropriately fixed and investigated by light microscopy, and scanning and transmission electron microscopy. the configuration of the iridocorneal angle tissues is similar to other nonprimate mammals in several respects, i.e. it possesses a deep cilia ...	1991	1810936
[the use of the measurement for the electrical resistance in order to standardize experimental cavities].	for histological examination of the pulp responses to dental materials vital teeth are needed with an expected thickness of the cavity floor between 0.2 and 1.0 mm (din 13,930). in order to control the thickness of the cavity floor we used a method based on the measurement of the electrical resistance of the dentine layer, as previously described. the obtained results by evaluation the thickness of the floor of class v cavities, using the domestic pig as a model, indicate the accuracy of our met ...	1991	1816831
ultrastructural identification of langerhans cells in normal swine epidermis.	langerhans cells of the epidermis of 6-month-old white crossbred farm pigs were identified by electron microscopy. ultrastructurally they were similar to those described in other mammals. they were present in basal and suprabasal layers and were characterised by a lobulated nucleus and an electrolucent cytoplasm with occasional dendritic processes, and the absence of tonofilaments and specialised unions with surrounding keratinocytes. they were specifically identified by the presence of characte ...	1991	1817140
[high resolution chromosome g-banding pattern of domestic pig of china].	lising methotrexate or thymidine treatment to induce synchronous division, combined with gtg technique, the high resolution banded chromosomes of seven domestic pig breeds of china were investigated. no distinct difference was found among then. hence, in line with the international system for human cytogenetic nomenclature, a standard idiogram of high resolution g-banded karyotype of domestic pig is suggested in this paper. in the idiogrammatic presentation of g-banding pattern, all the regions ...	1991	1888527
immediate dressing of the burn wound--will it change its natural history?	thirty deep dermal burns were inflicted on six domestic pigs. on the treated animals, the epidermis was removed and immediately replaced with omiderm, xeroform or mettalin dressings. burns in which the blister was left intact or not dressed after epidermis removal, served as controls. macroscopic and microscopic assessment of the healing process was then carried out. surprisingly, the no-epidermis controls healed somewhat faster than did the untreated controls (those with blister intact). on day ...	1991	1892559
[the pig--an experimental model for transplantation of isolated islets pancreatic islets].	the authors present results of autotransplantation of the islets of langerhans of the pancreas in pigs and miniature pigs ("troll"). diabetes was induced by total pancreatomy. from the removed pancreas the islets of langerhans were separated by the method of intraductal perfusion with collagenase and implanted into the spleen or liver via the portal vein. the mortality on operation in pigs was 33%, in miniature pigs 20%. in domestic pigs normal blood sugar levels were achieved in 25% after impla ...	1991	1821478
asian taenia saginata: species or strain?	asian taenia has a special epidemiological pattern. many people eat raw and/or undercooked pork and pig viscera more often than that of cattle and acquire a t. saginata-like tapeworm infection. the pig has been found to be the most favorable laboratory intermediate host for four geographical strains of asian taenia. numerous pinpoint cysticerci have been found in naturally infected livers of one wild boar and six domestic pigs in taiwan. it is likely that pigs are the natural intermediate host o ...	1991	1822898
evaluation of intraosseous vs intravenous antibiotic levels in a porcine model.	to compare intraosseous vs intravenous routes of administration and their effects on serum levels of four antibiotics in an animal model.	1991	1858734
histochemical demonstration of zinc in the hippocampal region of the domestic pig: iii. the dentate area.	the distribution of zinc was described in the dentate area, a part of the hippocampal region, of the domestic pig. a modification of timm's sulphide silver procedure, the neo-timm method, was used for the histochemical demonstration of zinc. the staining of the dentate area exhibited a well-defined stratified pattern, the predominant part of the staining being restricted to the neuropil, although weakly stained nerve cell bodies were observed in the hilus fasciae dentatae. in the molecular layer ...	1991	1865008
ciclopiroxolamine cream 1%: in vitro and in vivo penetration into the stratum corneum.	studies were conducted to assess the penetration of 1% ciclopiroxolamine cream, establishing the concentrations of the antimycotic compound in different layers of the stratum corneum with two skin models. results of in vitro studies using skin from domestic pigs indicate that ciclopiroxolamine has the ability to penetrate fast into the epidermis, by inhibiting and killing inoculated trichophyton mentagrophytes. in vivo investigation of the stratum corneum has been performed in healthy human volu ...	1991	1878248
rapid and accurate high-performance liquid chromatographic method for the determination of 3-methylindole (skatole) in faeces of various species.	a rapid method for the determination of skatole (3-methylindole) in faeces by reversed-phase high-performance liquid chromatography is described. samples of 0.5 g were extracted with 2 ml of methanol. the extract was purified on amberlite xad-8. the lower limit of detection was 2.5 ng per injection (0.2 microgram/g faeces). the mean recovery of skatole was 95%, and the mean coefficients of variation were 7.0% (intra-assay) and 11.8% (inter-assay). skatole concentrations were clearly lower in fae ...	1991	1885705
in situ localization of transforming growth factor beta 1 in porcine heart: enhanced expression after chronic coronary artery constriction.	we investigated the expression of transforming growth factor beta 1 (tgf-beta 1), a polypeptide differentiation factor probably associated with angiogenic properties in chronically hypoperfused heart tissue. a slowly swelling ameroid constrictor was implanted around the coronary circumflex artery (cx) of young domestic pigs. two to three weeks after, significant cx stenosis of more than 90% and coronary collateralization could be demonstrated angiographically. the cx dependent experimental myoca ...	1991	1942095
cardiovascular effects of platelet-activating factor.	sudden release of platelet-activating factor (paf) into the circulation can cause hypotension, tachycardia, and circulatory collapse. to further examine this response, we performed detailed studies of cardiovascular function after paf administration to young domestic pigs and newborn piglets. our results indicate that circulatory dysfunction after paf reflects severe constriction of pulmonary resistance vessels and consequent acute right ventricular failure. although paf-induced coronary artery ...	1991	1819712