| dual effects of hemicholinium-3 at central cholinergic synapses. | 1. hemicholinium-3 (hc-3) has at least two presynaptic effects at cholinergic synapses between motor acon collaterals and spinal renshaw cells, neither of which influenced non-cholinergic excitatory synapses on dorsal horn interneurones. 2. one, which occurred independently of repetitive activity of the synapses and which resulted in increased latency of synaptic excitation, presumably involved changes in the properties of presynaptic fibres and terminals which influenced transmitter release. 3. ... | 1977 | 190385 |
| preparation of cell-free feline oncornavirus-associated cell membrane antigen. | cell-free feline oncornavirus-associated cell membrane antigen (focma) was prepared from a feline lymphoblastoid cell line of tumor origin (fl-74). membrane fractions, separated on sucrose density gradients, and papain-solubilized products were found to contain focma as determined by their capacity to inhibit reference cytotoxic cat antisera. | 1977 | 190418 |
| [effect of ammonium acetate on depolarization processes in the central terminals of primary afferents]. | experiments on cats determined that ammonium acetate injected intravenously (2-4 mm/kg) supressed the processes of primary afferent depolarization (pad) which are thought to be responsible for the presynaptic inhibition of spinal reflexes. the supression was transient and proceeded in paralle to depression of postsynaptic inhibition of monosynaptic reflexes. ammonium acetate slightly decreased the amplitude of the negative postsynaptic potentials recorded form the dorsal surface of lumbar cord i ... | 1977 | 190547 |
| evaluation of a new feline rhinotracheitis virus vaccine. | | 1977 | 190756 |
| the interaction of cyproheptadine with agents affecting neuromuscular transmission. | using the rat phrenic nerve diaphragm, cyproheptadine at concentrations of 1 to 8 mug/ml did not affect or slightly augmented indirect muscle twitches, but potentiated blockade by tubocurarine, decamethonium and succinylcholine, and antagonized the augmentation of twitches by neostigmine. ketamine, choline and tetraethylammonium at concentrations causing no blockade produced, when given after cyproheptadine (6 mug/ml), a high degree of blockade. at concentrations of 9 to 20 mug/ml, cyproheptadin ... | 1975 | 190863 |
| evaluation of a feline viral rhinotracheitis-feline calicivirus disease vaccine. | an attenuated respiratory disease vaccine against feline viral rhinotracheitis (fvr) and feline calicivirus (fcv) disease was evaluated for safety and efficacy in specific-pathogen-free cats. twenty cats were vaccinated twice intramuscularly, with 28 days between vaccinations. ten unvaccinated cats were used as contact controls. adverse effects were not noticed after vaccination, and the vaccinal virus did not spread to contact controls. arithmetical mean serum-neutralizing titers against vaccin ... | 1977 | 190925 |
| a mathematical model for the mechanism of rapid eye movements induced by an anticholinesterase in the decerebrate cat. | the oculomotor pattern which appears in intact preparations during desynchronized sleep is characterized by the irregular occurrence of isolated ocular movements and bursts of rapid eye movements (rem). this complex oculomotor pattern results from the activity of two premotor structures which influence the extraocular motoneurons during this phase of sleep: one is located in the pontine reticular formation, the other in the vestibular nuclei. in the decerebrate preparation the intravenous inject ... | 1976 | 190960 |
| selective discharge of pontine neurons during the postural atonia produced by an anticholinesterase in the decerebrate cat. | i. episodes of postural atonia associated with bursts of rem similar to those which occur spontaneously either in the intact preparation during desynchronized sleep, or in the chronic decorticate or decerebrate preparations, can be elicited in acute decerebrate cats following intravenous injection of small doses of an anticholinesterase. the present experiments were performed in precollicular decerebrate animals in order to identify the pontine neurons which show increases in their firing rate r ... | 1976 | 190961 |
| the oscillatory system responsible for the oculomotor activity during the bursts of rem. | 1. in precollicular decerebrate cats the electrical activity of single pontine neurons was recorded before, during and after the episodes of postural atonia produced by i.v. injection of 0.03-0.1 mg/kg of eserine sulphate. these episodes were characterized by the regular occurrence of horizontal conjugate eye movements, which were mainly grouped in bursts of rem; moreover, a burst of rem in one direction was generally followed by a burst of rem in the opposite direction. 2. among the recorded un ... | 1976 | 190962 |
| sequential discharges of phasic activities (pgo waves) during paradoxical sleep after selective cortical lesions in the cat. | we investigated the role that cortical areas have upon the sequences of pgo waves and associated phasic activity in the lateral rectus muscles of the eyes (palre) during ps. we performed several combined type of lesions (bilateral ablations of frontal lobes carried out in two sessions, or occipital lesions combined with bifrontla lobotomies). we used statistical methods previously described for the normal cat (4). we showed that frontal lesions need to be bilateral in order to be effective, that ... | 1976 | 190963 |
| cyclic amp and ultrastructural organization of the nerve cell nucleus: stimulation of nuclear microtubules and microfilaments assembly in sympathetic neurons. | as we have previously shown for electrical stimulation, in vivo cyclic amp analogues and theophylline induce an increase (up to 8.5-fold) in the frequency of microtubular-microfilamentous inclusions in the nucleus of sympathetic neurons. these drugs, like electrical stimulation, do not modify the ultrastructural organization of such inclusions, which is briefly reviewed in the present study with the help of tilting experiments. such data consistent with our previous opinion that microtubules and ... | 1977 | 191148 |
| method for reliably recording geniculate spikes during paradoxical sleep in the cat. | a simple procedure is described which allows an investigator to implant electrodes which will reliably record phasic spikes in the lateral geniculate nucleus during paradoxical sleep. this procedure relies on recording photically evoked activity during the implantation of the geniculate electrode and the fact that the distribution of such activity and phasic spikes during paradoxical sleep overlap within the lateral geniculate nucleus. the largest geniculate spikes were recorded during paradoxic ... | 1976 | 191156 |
| involvement of central alpha-adrenoceptors in the hypotensive and bradycardic effects of (--)-delta 9-trans-tetrahydrocannabinol. | i.v. administration of (--)-delta9-trans-tetrahydrocannabinol (delta 9-thc) to chloralose-anesthetized cats produced a decrease in blood pressure and heart rate. studies conducted to investigate the mechanism of these changes revealed that the hypotensive and bradycardic effects of delta 9-thc (0.1 mg/kg, i.v.) could be significantly antagonized following intraventricular (i.v.t.) perfusion with alpha-adrenergic receptor blocking agent phentolamine, while a larger dose of delta 9-thc (0.25 mg/kg ... | 1977 | 191263 |
| subcellular localization of cyclic nucleotide phosphodiesterase in the caudate nucleus. | | 1977 | 191273 |
| changes of the phosphatidylcholine content and the number of synaptic vesicles in relation to the neurohumoral transmission in sympathetic ganglia. | in sympathetic ganglia stimulated in the presence of hc-3, the reduction in number of synaptic vesicles was observed to be accompanied by a significant decrease of the ganglionic phosphatidylcholine content. | 1976 | 191277 |
| stimulation of glucagon and inhibition of insulin secretion evoked from carotid baroreceptors. | the influence from carotid baroreceptors on portal immuno-reactive glucagon and insulin levels and on arterial plasma glucose concentration was studied in vagotomized cats by sectioning of the sinus nerves. such a complete elimination of the afferent baroreceptor discharge caused a prompt and pronounced increase in the glucose and glucagon levels, whereas the insulin concentration significantly decreased. the role of vascular barorecptors in the hyperglycemic response to hemorrhage is discussed. | 1977 | 191288 |
| [analysis of the effect of methylene blue on different links in the synaptic transmission of autonomic ganglia]. | | 1976 | 191302 |
| felv epidemiology in los angeles cats: appraisal of detection methods. | we investigated the reliability of the fixed cell indirect fluorescent antibody (ifa) peripheral blood smear test as an index of systemic infection with felv. positive results with this test were found to correlate well with detectable felv p30 antigen in bone-marrow smears by ifa, in serum and tissue by competition immunoassays, and with type-c particles in bone marrow or spleen by electron microscopy. most cats with lymphoma, anemia or infectious peritonitis were positive for felv and showed a ... | 1977 | 191415 |
| retinal neoplasia and dysplasia. i. induction by feline leukemia virus. | feline leukemia virus, a naturally occurring c-type virus (oncorna virus), was injected systemically and intraocularly into fetal and newborn kittens. a light microscopy study of the resultant ocular tumor changes was carried out. one animal developed an intraocular tumor of apparent retinal origin. eight animals showed intraocular neoplastic cell infiltration. the most common ocular change observed was retinal dysplasia. sequential histologic examination of enucleated eyes showed diffuse intrao ... | 1977 | 191424 |
| organization of visual inputs to interneurons of lateral geniculate nucleus of the cat. | 1. two groups of interneurons that are involved in the organization of the lateral geniculate nucleus (lgn) are described. the cell bodies of one group lie within the lgn; these units are referred to as intrageniculate. the cell bodies of the other group are found immediately above the lgn at its border with the perigeniculate nucleus; these units are referred to as perigeniculate. 2. intrageniculate interneurons have center-surround receptive fields that resemble those of relay (principal) cell ... | 1977 | 191574 |
| phenobarbital actions in vivo: effects on extra cellular potassium activity and oxidative metabolism in cat cerebral cortex. | extracellular potassium activity and changes in the reduction levels of intramitochondrial pyridine nucleotide (nad) and cytochrome-a,a3 were monitored in the cerebral cortex of cats at rest and during electrical stimulation, before and after administration of sodium phenobarbital. stimulation of the cortical surface evoked a transient increase in the level of oxidized nad which was proportional in magnitude to the associated transient elevation of extracellular potassium. phenobarbital (i.v.) p ... | 1977 | 191589 |
| the effects of neomycin upon transmitter release and action. | these experiments were designed to determine the site and mechanism of action of neomycin on cholinergic transmission. these agents depressed the response of rat diaphragm preparations to phrenic nerve stimulation and to injected acetylcholine (ach); however, equi-effective neuromuscular blocking concentrations of neomycin (6 x 10(-4) m), streptomycin (1.2 x 10(-3) m) or d-tubocurarine (6.5 x 10(-7) m) reduced the muscle response to injected ach to 54,27 and 15% of control, respectively, suggest ... | 1977 | 191590 |
| [pain mechanism (author's transl)]. | | 1977 | 191764 |
| feline oncornavirus-associated cell-membrane antigen (focma): distinction between focma and the major virion glycoprotein. | the humoral antibody response of feline leukemia virus (felv)-exposed cats to the feline oncornavirus-associated tumor cell-membrane antigen (focma) is directly correlated with immunosurveillance against tumor development under natural conditions. by means of membrane immunofluorescence and radioimmunoprecipitation, the antibody response to focma was found to be independent of the antibody response to the major envelope and core proteins of felv, gp70 and p30. this was especially true for health ... | 1977 | 191832 |
| functional characteristics of the intraspinal spread of viscerosomatic activity. | the functional characteristics of the intraspinal spread of the dual-component viscerosomatic reflex response were studied in chloralose-anaesthetized cats. in the region of the direct inputs of splanchnic afferents into the spinal cord, the initial part of the early (propriospinal) component is evoked by afflux from the extraspinal pathway in the sympathetic chain and has the shortest latent period. at segment th8 to th12 level this was 5.2--8.1 msec; cranially and caudally from this level it w ... | 1976 | 191857 |
| [antagonism between focal epilepsy and taurine administered by cortical perfusion]. | the therapeutic action of taurine cortical perfusion was tested in cats affected with premarin and cobalt cortical epileptogenic foci. in all animals taurine provoked the disappearance of eeg epileptic abnormalities. in the case of premarin focus the effect appeared more quickly than in the cobalt one. this different time-course, according to previous reports on the antiepileptic action of the parenteral administration of the amino acid, suggests the hypothesis of a taurine direct inhibitory act ... | 1976 | 191897 |
| feline mammary gland tumors. | | 1977 | 191974 |
| an immunologic approach to the treatment of cancer. | | 1977 | 191975 |
| feline leukemia virus. its related diseases and control. | | 1977 | 191976 |
| experimental induction of feline viral rhinotracheitis virus re-excretion in fvr-recovered cats. | the re-excretion of feline viral rhinotracheitis (fvr) virus (feline herpesvirus i) by fvr-recovered cats is recorded both spontaneously and following a variety of stimuli, namely, corticosteroid administration, change of housing, and parturition and lactation. at least 27 of 33 (82%) fvr-recovered cats studied were shown to be viral carriers. the carrier state was characterised by periods of viral latency interspersed with episodes of viral shedding. administration of 0-75 mg dexamethasone trim ... | 1977 | 191978 |
| substance p and primary afferent transmission. | substance p has a powerful excitant action on spinal motoneurons of the newborn rat, and the action is specifically antagonized by lioresal, which also readily blocks spinal reflexes involving primary afferent transmission. substance p is highly concentrated in bovine and feline dorsal roots as well as in the dorsal part of the dorsal horn of cat spinal cord. there is evidence that substance p is synthesized in spinal ganglia, transported through the dorsal roots and stored in the axon terminals ... | 1976 | 192049 |
| type c virogenes: genetic transfer and interspecies transfer. | | 1976 | 192063 |
| presynaptic receptor systems in catacholamingergic transmission. | | 1977 | 192238 |
| [the protecting action of a combination of vasoactivating substances (crp) on disturbances of the cerebral blood flow and metabolism and the cortical electrical activity (author's transl)]. | the effect of anoxia and direct cortical stimulation was investigated in control, hypotensive and post reinfusional periods, before and after treatment with a combination of coumarin/rutin sulphate sodium salts/proxyphylline (crp, theokal). theokal lowered the mean arterial pressure and a slight nadh oxidation appeared. blood flow did not change after theokal in spite of the 30 mm hg blood pressure drop. this suggests an improved oxygen supply to the cortical cells. the increase in anoxic nadh r ... | 1977 | 192249 |
| [relationship between a state of sleep and wakefulness and transmission of an afferent signal through the posterior ventral nucleus of the thalamus]. | chronic experiments were carried out on nonanesthetized cats. a study was made of peculiarities attending the transmission of the afferent signals and the following inhibitory processes in the posterior ventral nucleus of the thalamus, depending on the state of sleep and wakefulness. transmission of the signals decreases during the dreaming condition and the slow-wave sleep, and increases during the active states of alert cats. in paradoxical sleep the signal transmission is at the same level as ... | 1977 | 192390 |
| [depressor reactions to sural nerve stimulation in intact unanesthetized cats]. | changes in the arterial pressure, in the heart and respiratory rate evoked by the gastrocnemuis nerve stimulation were studied on conscious cats before and during intravenous injection of noradrenaline. stimulation of the gastrocnemius nerve increased the arterial pressure, the heart and respiratory rates. the same stimulation of the nerve during hypertension caused by noradrenaline injection led to the fall of arterial pressure and tachycardia. the depressor response failed to change under the ... | 1977 | 192391 |
| effects of locus coeruleus lesions upon cerebral monoamine content, sleep-wakefulness states and the response to amphetamine in the cat. | the purpose of the present study was to investigate the effects of complete lesions of the noradrenaline locus coeruleus neurons upon wakefulness and paradoxical sleep. radiofrequency lesions of the nucleus were performed in 8 chronically implanted cats which were continuously recorded with an eeg for 5 days prior to and 21 days following the lesions, when they were sacrificed. in 3 of these animals amphetamine (2 mg/kg) was administered on one control day and on the 10th day post-lesion. follow ... | 1977 | 192414 |
| temporal patterns, their distribution and redundancy in trains of spontaneous neuronal spike intervals of the feline hippocampus studied with a non-parametric technique. | a modification of the non-parametric technique for the analysis of temporal patterns in long trains of single neuronal spike intervals has been described and tested empiracally. the technique is based on inequality testing of sequential pairs of intervals. if the second interval in a pair is longer or shorter than or equal to the first interval, a(+), a(-), and a (0) is recorded respectively in sequential bins of the computer memory. subsequently, the long sequences of signs are arranged into tr ... | 1977 | 192416 |
| the epidemiology of the feline leukemia virus (felv). | clustering of cases of feline lymphosarcoma (lsa) has been observed by veterinarians for many years. in 1964 it was discovered that feline lsa was caused by an oncornavirus, the feline leukemia virus (felv). in 1970, a simple, indirect immunoflourescent antibody (ifa) test for felv was developed which enabled large numbers of cats, living in their natural (household) environments, to be tested for the virus. in one study, over 2,000 cats were tested and the results showed conclusively that felv ... | 1977 | 192437 |
| contractile and biochemical responses of cardiac and skeletal muscle to isoproterenol covalently linked to glass beads. | the effects of (-)-isoproterenol covalently linked to glass beads on inotropic state, cyclic amp concentration, and phosphorylase b to a conversion was studied in cat and guinea pig papillary muscles. biochemical responses also were measured in mouse diaphragm sections. in cat papillary muscles under normal conditions and in guinea pig muscles partly depolarized with 22 mm k+ an increased inotropic state and phosphorylase activation could be dissociated from the formation of cyclic amp. this con ... | 1977 | 192486 |
| [mechanisms of participation of the sensomotor cortex in controlling movements]. | neuromorphological, neurophysiological and biomechanical studies in cats revealed cortical structural neuronal modules and functional units of different grades of complexity. single systemic principle was determined for the sensorimotor cortex activity: structurally organized neuronal modules, having distributed outputs, can be involved in different functional units for purposeful movements. specific lemniscal signals concerning the movements are the factor which filters inflow of teleceptive in ... | 1977 | 192606 |
| isolation of aleutian disease virus of mink in cell culture. | aleutian disease virus, the causative agent of a persistent infection in mink, was isolated in a continuous line of feline renal cells when the cultures were maintained at reduced temperature (31.8 degrees). after serial in vitro passage of the virus at this temperature it had an optimum replication temperature of 37 degrees. an immunofluorescence focus assay was found to be suitable for virus quantitation. the cultured virus reproduced aleutian disease in mink, and the virus could be reisolated ... | 1977 | 192696 |
| the scintigraphic investigation of sacroiliac disease. | bone scintigraphs obtained with both technetium-99m polyphosphate and technetium-99m pyrophosphate have been abnormal at the sacroiliac joints of 44 patients with definite ankylosing spondylitis (as). because of the normal registration of the sacroiliac joints on bone scintigraphy, it has been necessary to develop a profile-scan technique to quantify the abnormality that proves to be significantly different from the normal finding. in 17 patients with a strong clinical suspicion of as but normal ... | 1977 | 192857 |
| cutaneous facilitation of transmission in reflex pathways from ib afferents to motoneurones. | 1. the effect of volleys in low threshold cutaneous afferents upon transmission of synaptic action from ib afferents to motoneurones has been investigated with intracellular recording from alpha motoneurones to hind limb muscles. 2. there was facilitation from cutaneous afferents of transmission in excitatory and inhibitory reflex pathways from ib afferents without any evidence for difference in effect on di- and trisynaptic pathways. it is postulated that volleys in cutaneous afferents evoke ex ... | 1977 | 192879 |
| [inhibitory mechanisms within the receptive fields of x-and y-type retinal ganglion cells of the cat (author's transl)]. | two-stages of the inhibitory mechanisms were assumed within the on-center receptive field (rf) of the cat's retinal ganglion cell on the basis of the following two experiments: 1) effect of background intensity upon the magnitude of the response to the rf-centered spot of stimulus, and 2) the time course of the inhibitory effect when the additional spot of light is presented in the same rf center region. the first stage is an inhibitory feed-back from horizontal cell to the photoreceptor. both x ... | 1976 | 192887 |
| ascending spinal tracts of the spino-bulbo-spinal reflex in cats. | twenty-six chloralosed cats were employed in order to determine spinal ascending pathways of the spino-bulbo-spinal (sbs) reflex evoked by stimulation of the sural nerve. 1. partial spinal transection of the dorsal part of the lateral funiculus abolished the sbs reflex ipsilateral to sural nerve stimulation. 2. by recording spinal cord potentials in response to sural nerve stimulation two pathways were established in the dorsolateral funiculus as the spinal ascending tracts of the sbs reflex; on ... | 1976 | 192931 |
| studies on cytopathogenic viruses from cats with respiratory infections. iii. isolation and certain properties of feline herpesviruses. | | 1977 | 192933 |
| rd-114 and feline leukaemia virus genome expression in natural lymphomas of domestic cats. | | 1977 | 193031 |
| prevention of oncornavirus-induced sarcomas in cats by treatment with antiviral antibodies. | | 1977 | 193042 |
| [transmission of reticulofugal activity through the ventromedial group of propriospinal neurons in cats]. | responses of propriospinal interneurons localized in the ventromedial regions of the cat lumbar cord to the reticulospinal tract stimulation were studied. monosynaptic excitatory action usually accompanied by di- and polysynaptic components was found in most units. strong single stimuli were able to evoke discharges only in some cells, while temporal summation was necessary in many others. excitation of neurons was followed by a short postactivation inhibition limiting the maximal discharge freq ... | 1977 | 193059 |
| sensitivity of components fo the central vestibular complex to pentobarbital. | | 1977 | 193066 |
| the role of the blood in metabolism of prostaglandin e1 in the cat lung. | we found that when 15-keto-pge1 was added to cat blood, it was converted to 13, 14-dihydro-15-keto-pge1 (dihydro-keto-pge1) by a nadh-dependent enzyme associated with some formed element(s) in the blood. when pge1 was injected into the pulmonary artery of blood-perfused lungs, the only metabolite detectable in the pulmonary venous blood was the dihydro-keto-pge1. however, when the lungs were perfused with an artificial perfusate containing no blood cells, a small amount of 15-keto-pge1 was detec ... | 1977 | 193152 |
| pontine reticular formation neurons: relationship of discharge to motor activity. | the discharge correlates of pontine reticular formation units were investigated in unrestrained cats. in agreement with previous investigations using immobilized preparations, we found that these cells had high rates of activity in rapid eye movement sleep, and responded in waking to somatic, auditory, and vestibular stimuli at short latencies, many having polysensory responses and exhibiting rapid "habituation." however, despite the sensory responses of these cells, most unit activity could not ... | 1977 | 193185 |
| dibutyryl cyclic adenosine monophosphate effects in the ischemic-hypoxic cat. | the effects of dibutyryl cyclic adenosine monophosphate (db-camp) were studied in fifty cats, twenty anesthetized with pentobarbital and thirty with halothane. nasopharyngeal temperature and paco2 were maintained at normal values. somatosensory evoked response was monitored and used as an indicator of cerebral cortical function. ischemic hypoxic injury was produced by an orthopedic tourniquet snugly applied around the animal's neck and inflated for a period of fifteen minutes. this method produc ... | 1977 | 193218 |
| the endocrine cells of the pancreas and related tumours. ultrastructural study and classification. | up to seven endocrine cell types have been identified ultrastructurally in the pancreas, including glucagon a cells, insulin b cells, somatostatin d cells, pancreatic peptide f cells and 5-hydroxytryptamine ec cells. in addition, d1 cells, which have been proposed as the cell type producing vip and possible p cells of unknown function are seen. various patterns of endocrine cell differentiation have been found in 20 endocrine pancreatic tumours. well and poorly differentiated b cells have been i ... | 1977 | 193245 |
| defectiveness of a feline sarcoma virus demonstrable by the acquisition of a new envelope antigenic type by phenotypic mixing. | | 1977 | 193272 |
| [role of cyclic adenosine monophosphate in regulating the secretory function of the digestive glands (review of the literature)]. | | 1976 | 193298 |
| morphological and histochemical organization of the flexor carpi radialis muscle in the cat. | most studies concerning the structure and function of skeletal muscle have utilized the hind limb of the experimental animal. however, it has been shown that the number of behavioral tasks performed by the cat's forelimb is greater than that of the hind limb. in addition, the forelimb muscles exhibit a functional complexity not observed in hind-limb musculature. the purpose of this study was to investigate the distribution of fast-twitch and slow-twitch muscle fibers and muscle spindles in the f ... | 1977 | 193389 |
| single units activities in ventral posterior and posterior group thalamic nuclei during nociceptive and non nociceptive stimulations in the cat. | the purpose of this study was to define, in hyperventilated and unanesthetized cats, the role of the posterior thalamic nuclei in pain mechanisms. unit activities of these structures were compared to those of the ventro-posterior nucleus during non-noxious (touch, brushing) and noxious stimulations (pinches and intra-arterial injections of bradykinin into the limbs). 135 cells with somatic inputs and clear peripheral excitatory receptive field were studied. the cells driven by noxious stimulatio ... | 1977 | 193452 |
| effects of a single methylprednisolone dose on a facilitatory response of mammalian motor nerve. | long-term glucocorticoid dosing directly enhances a facilitatory function of cat soleus motor nerve terminals. posttetanic potentiation (ptp) of soleus contraction is a manifestation of this prejunctional facilitation. the present study demonstrates that the same enhancement of facilitation is produced with a single large intravenous dose methylprednisolone. the single dosing method, however, showed an initial suppression of facilitation that neared recovery in four hours. thereafter, the charac ... | 1977 | 193476 |
| neurobiology of aggressive behavior. | causality, neurological mechanisms, and behavioral manifestations may be heterogeneous in different forms of aggressive behavior, but some elements are shared by all forms of violence, including the necessity of sensory inputs, the coding and decoding of information according to acquired frames of reference, and the activation of pre-established patterns of response. understanding and prevention of violence requires a simultaneous study of its social, cultural, and economic aspects, at parity wi ... | 1976 | 193531 |
| penicillin-induced spinal seizures: selective effects on synaptic transmission. | | 1977 | 193709 |
| gaba in the caudate nucleus: a possible synaptic transmitter of interneurons. | | 1977 | 193718 |
| some pharmacological effects of disopyramide and a metabolite. | | 1976 | 193744 |
| oxidative enzymes in the sebaceous glands of the domestic cat. | the distribution and activities of several oxidative enzymes in various regions of the sebaceous glands of the domestic cat have been studied. the results obtained emphasize the outstanding importance of nadp-linked dehydrogenases for lipogenesis during sebum production. in particular, the reactions for glucose-6-phosphate dehydrogenase were very strong. among the nad-linked dehydrogenases investigated, lactate dehydrogenase showed strong activity in the peripheral cells of the sebaceous gland. ... | 1977 | 193809 |
| herpes virus infections of animals--a brief review. | | 1977 | 193824 |
| sero-diagnostic aspects of feline herpesvirus infection. | | 1977 | 194079 |
| distribution of exogenous cyclic adenosine 3', 5'-monophosphate in rabbits and cats. | the appearance and disapperance of total radioactivity in plasma and cerebrospinal fluid (csf) were studied after a single intravenous injection of tritium-labelled cyclic adenosine 3', 5'-monophosphate (camp) into rabbits and cats. the radioactivity was rapidly cleared both from plasma and relatively stable when compared to plasma camp level. exogenous camp in plasma does not seen to distribute into csf by a simple diffusion. | 1977 | 194115 |
| [vaccinations of animals and human health (author's transl)]. | vaccination of animals may have both positive and negative effects on human health. the negative consequences largely occur with live vaccines. the protection provided by vaccination to animals is taken advantage of for human health in the most diverse ways, both directly and indirectly. typical examples are vaccination of dogs and cats against against rabies and inoculation against diseases of cattle, horses and dogs in which reoviruses of serotypes 1, 2 and 3 are involved. an important contrib ... | 1977 | 194146 |
| the role of cutaneous mechanoreceptors in thermal sensation and pain. | the functional behavior of slowly adapting cutaneous mechanoreceptors under combined thermal-mechanical stimulation was investigated by single-unit recordings from the lumbar dorsal roots of the cat. increased sensitivity to bimodal stimulation was observed in 24 of the 28 units studied, employing stimulus-response functional behavior as the basis for judgment. low-threshold receptors generally did not exhibit increased spontaneous firing as accompaniment to heightened sensitivity, while such en ... | 1976 | 194204 |
| pharmacological evidence in vitro and in vivo for functional beta1 receptors in the cerebral circulation. | blood flow in the caudate nucleus was measured by the thermoclearance technique in non-anesthetized rabbits, accompanied by recording of electrocorticogram, systemic blood pressure, and pao2 and paco2 (mass spectrometry). isoprenaline increased caudate nucleus blood flow and reduced systemic blood pressure. the beta2-receptor agonist, terbutaline, on the other hand, had only peripheral effects. the caudate nucleus flow response was selectively blocked by the beta1-receptor antagonist, practolol, ... | 1977 | 194216 |
| feline oncornavirus-associated cell membrane antigen: expression in transformed nonproducer mink cells. | the feline oncornavirus-associated cell membrane antigen (focma) is a target for naturally occurring immunity that protects the cat against development of fibrosarcoma and leukemia. feline sarcoma virus-transformed "nonproducer" mink cells express high levels of focma, but not the major viral structural proteins. transformation of the same cells by murine sarcoma virus, or infection with feline leukemia virus, which is nontransforming for epithelial or fibroblastic cells, did not induce focma. t ... | 1977 | 194310 |
| rejectability of virus-induced tumors and nonrejectability of spontaneous tumors: a lesson in contrasts. | in contrast to the excellent surveillance against tumors induced by the ubiquitous viruses in their natural host species, spontaneous tumors developing naturally, without experimental interference, evoke little or no rejection reaction. this may be viewed in relation to the natural history of tumors. in most cases, tumors evolve in several steps, with a successful of clonal variants following each other, characterized by increasing independence of host regulations (including immune restrictions) ... | 1977 | 194366 |
| direct isolation of xenotropic retraviruses from the nih swiss mouse uterus. | | 1977 | 194402 |
| [neurophysiologic analysis of the effect of acth and hydrocortisone on conditioned reflex behavior in cats]. | in defensive behaviour of cats, acth eliminated extinction delay, evoked by electrical stimulation (with constant parameters) of the midbrain reticular formation, and enhanced the activating influence of the thalamus reticular zone. hydrocortisone produced opposite effects. in alimentary behaviour, the adaptive hormones enhanced the facilitating effect on extinction, induced by stimulation of non-specific structures and the hypothalamus. however, during hydrocortisone action, encephalographic si ... | 1977 | 194432 |
| neuromuscular block by antibiotics: polymyxin b. | characteristics of neuromuscular block produced by polymyxin b (pxb) were examined in 12 anesthetized cats, using sciatic nervetibialis anticus muscle preparations. the ed50 was 6.7 (+/- 1.4, sd) pxb base/kg body weight. the ed95 was 10.8 (+/- 2.4) mg/kg. spontaneous recovery from 25 percent of control to 75 percent of control required 72 (+/- 16) minutes. during a 50 percent block, train-of-four twitches elicited at 2 hz faded with a train-of-four ratio of 0.42 (+/- 0.13), but the tetanus did n ... | 1977 | 194505 |
| basic mechanisms of prostaglandin action on autonomic neurotransmission. | | 1977 | 194531 |
| histaminergic mechanisms in brain. | | 1977 | 194532 |
| biology of breast preneoplasia. | the literature dealing with mammary cancer and the presence of the identifiable preneoplastic lesions in the mammary gland of several species has been reviewed. a discrete morphologically identifiable lesion with a high malignant potential is considered preneoplastic. lobuloalveolar lesions have been identified in the human mammary gland which fit most of the criteria for preneoplasia. the lesions, hyperplastic atypical lobules, are multicentric, have a high statistical association with breast c ... | 1977 | 194676 |
| immunity to leukemia, lymphoma, and fibrosarcoma in cats: a case for immunosurveillance. | | 1977 | 194751 |
| passive immunity to feline leukemia: evaluation of immunity from dams naturally infected and experimentally vaccinated. | antibodies against feline leukemia virus (felv) and the feline oncornavirus-associated cell membrane antigen (focma) were transferred from pregnant cats to their suckling kittens. all of these kittens were protected against infection and oncogenesis by virulent felv when challenged at 2 weeks of age. suckling kittens acquired 25 to 100% of maternal virus-neutralizing and focma titers by 3 days of age, and titers underwent linear decay to undetectable levels by 2 to 3 months of age. focma antibod ... | 1977 | 194840 |
| increase in serum ige levels of ovalbumin-sensitized cats and the detection of elastase and collagenase activities in secretions of sensitized feline alveolar macrophages challenged in vitro. | the feline model of respiratory hypersensitivity induced by intraperitoneal injection of ovalbumin has been studied. ige serum antibodies were present for 3-10 weeks following sensitization, with maximum titers occurring between 50 and 70 days. similarly, peak passive cutaneous anaphylaxis reactions occurred between 50 and 70 days. alveolar macrophages, obtained by tracheal lavage at 65 days after sensitization, produced elastase like and collagenase-like secretions 48 h after challenge with ova ... | 1977 | 194842 |
| [acupuncture for pains of the face and the head is there any reasonable application? (author's transl)]. | the physiological bases of the treatment with acupuncture as well as its practical application in pain therapy were discussed at the meeting of the orl-society of munich on the 4th december, 1976. | 1977 | 195167 |
| presence of beta-adrenoreceptors in the hypothalamus; their importance for the pressor response to hypothalamic stimulation. | the posterior hypothalamus of cats anaesthetized with pentobarbital sodium was superfused and electrically stimulated with a push-pull cannula. superfusion of the hypothalamus with (+/-)-, (-)-propranolol, sotalol, practolol or metoprolol caused a concentration-dependent inhibiton of the pressor response to hypothalamic stimulation. (+/-)-propranolol and a procaine concentration equi-anaesthetic to the concentration of (+/-)- and (-)-propranolol were ineffective. lower concentrations of proprano ... | 1977 | 195227 |
| facts and reflections on thalamocortical reverberation of impulses. | experiments on cats, either unanesthetized or anesthetized with various doses of pentobarbital, showed that the cortical rhythmic after-discharge ("slow after-activity"), which has been regarded as a manifestation of reverberation of impulses in thalamocortical circuits [17], consists of a burst of spontaneous "spindles" evoked by stimulation. this conclusion is supported by the following facts: spontaneous "spindles" and the rhythmic after-discharge respond absolutely identically (disappear) to ... | 1976 | 195232 |
| synaptic processes in pericruciate cortical neurons evoked by pyramidal tract stimulation in cats. | in cats anesthetized with chloralose and pentobarbital and immobilized with d-tubocurarine activity of 423 pericruciate cortical neurons was recorded (342 extra- and 81 intracellularly); 78 neurons had spontaneous activity. stimulation of the pyramidal tract evoked antidromic action potentials in the pyramidal neurons with a latent period of 0.5-16.0 msec. recurrent and lateral psps also developed both in pyramidal and in unidentified neurons in all layers of the cortex; ipsps were recorded in 4 ... | 1976 | 195233 |
| mechanosensitivity of dorsal root ganglia and chronically injured axons: a physiological basis for the radicular pain of nerve root compression. | the radicular pain of sciatica was ascribed by mixter and barr to compression of the spinal root by a herniated intervertebral disc. it was assumed that root compression produced prolonged firing in the injured sensory fibers and led to pain perceived in the peripheral distribution of those fibers. this concept has been challenged on the basis that acute peripheral nerve compression neuropathies are usually painless. furthermore, animal experiments have rarely shown more than several seconds of ... | 1977 | 195255 |
| analogies and differences between reserpine pgo wave discharges and oculomotor phasic activity during paradoxical sleep in the cat. | in the present study the analogies and differences between phasic pgo activity of parodoxical sleep and the reserpine induced pgo waves were investigated. the oculomotor phasic activities in chronic cats were studied. it appeared that the intrinsic organisation of latencies and the appearance of phasic waves in the four structures studied were common to both experimental situations. however the sequential patterns of discharges were different in ps and under reserpine treatment. | 1977 | 195316 |
| vagal control of diaphragm timing in cat while breathing at elevated lung volumes. | this paper proposes and tests an hypothesis to account for the roles of the volume and rate components of vagal feedback in determining the steady-state pattern of breathing during continuous positive pressure breathing (ppb) and expiratory threshold loading (etl) in dial anesthetized cats. during ppb the duration of diaphragm activity (tdi) is shortened; the duration of its expiratory pause (tep) is lengthened with little or no change in cycle duration (tt); with onset of inspiration, flow (dv/ ... | 1977 | 195322 |
| nucleus raphe magnus: a common mediator of opiate- and stimulus-produced analgesia. | | 1976 | 195380 |
| the beta-adrenoceptors responsible for a direct relaxation of the uncontracted nictitating membrane of the anaesthetized cat. | direct relaxation of the nictitating membrane of the anaesthetized cat was produced by close intra-arterial injections of single doses of isoprenaline and other beta-adrenoceptor agonists. this response was relatively resistant to blockade by doses of propranolol that almost abolished the corresponding positive chronotropic and vasodepressor responses. construction of dose-response curves, however, revealed antagonism of all three parameters by propranolol and different sensitivities of the para ... | 1977 | 195544 |
| influence of apomorphine on sympathetic neural transmission in the nictitating membrane of the cat. | apomorphine inhibited the nictitating membrane contractions elicited by pre- or postganglionic stimulation of the cervical sympathetic nerve but did not influence even in higher doses the effect of noradrenaline and adrenaline on this organ. the inhibition evoked by apomorphine could be antagonized by haloperidol but was not influenced by phentolamine and propranolol. dopamine and noradrenaline inhibited the nictitating membrane contractions elicited by nerve stimulation, but clonidine was ineff ... | 1977 | 195545 |
| pharmacology of the hemodynamic and myocardial response to occlusion of the mesenteric artery in the cat. | occlusion of the superior mesenteric artery in the cat produces increases in heart rate, systemic pressure, cardiac output and muscle blood flow. total peripheral resistance is reduced and regional resistance in skin increased. blockade of the right and left cardiac nerves with xylocaine lowered basal heart rate and reduced cardiac output. the increase in heart rate produced by occlusion of the artery (mao) was prevented by blockade of the stellate ganglia and cardiac nerves. propranolol lowered ... | 1977 | 195546 |
| [relations between the unit activity of the vermis cerebelli and the phasic waves of the electrocerebellogram during sleep in chronic cats]. | | 1977 | 195548 |
| the effects of l9394 on adrenergic transmission in the cat spleen [proceedings]. | | 1977 | 195662 |
| histochemical and physiological profile of a skeletofusimotor (beta) unit in cat soleus muscle. | | 1977 | 195670 |
| action of a beta-bungarotoxin on autonomic ganglia and adrenergic neurotransmission. | a beta-bungarotoxin was isolated from the venom of bungarus multicinctus by column chromatography on sephadex g-50 and sp-sephadex. the toxin produced presynaptic effects on neuromuscular transmission with characteristics similar to those described by others. in a sympathetic ganglion, the toxin increased spontaneous acetylcholine (ach) release and decreased ach release evoked by preganglionic nerve stimulation. the toxin did not block the response of isolated ileum to cholinergic nerve stimulat ... | 1977 | 195692 |
| a study of binocular convergence in cat visual cortex neurons. | the average latency of cortical neuronal responses to electrical optic nerve (on) stimulation was 3.0 +/- 0.7 s.d. msec. no significant difference between latencies to ipsi- and contralateral on stimulation was found. binocularly excitable cells showed almost equal response latencies to stimulation of both nerves. the average latency of subcortically recorded geniculo-cortical fibers was 0.3 msec less, but showed the same variance as that of cortical cells, suggesting that in all cases direct mo ... | 1977 | 195824 |
| evidence that catecholamines are not the afferent transmitter in the cochlea. | beta-receptor blocking agents (practolol, propranolol) and alpha-receptor blocking agents (phenoxybenzamine, phentolamine), when applied intracochlearly do not eliminate the afferetn discharges or compound action potential of the cochlear nerve. under the assumption that the drugs used reach the synaptic site, it is therefore concluded that these drugs do not interfere with afferent synaptic transmission. phentolamine,, however, has a toxic effect upon the cochlea independent from the synaptic p ... | 1977 | 195827 |
| experimental cerebrovascular disorders: effects on cardiovascular functions and on cerebrospinal fluid production and constituents with special reference to cyclic amp. | | 1977 | 195829 |