| effects of activity in single sensory fibres on the discharge patterns of dorsal spinocerebellar tract cells. | 1. electrical activity of dorsal spinocerebellar tract (dsct) was recorded extracellularly and intracellularly in clarke's column nucleus. 2.trains of impluses were elicited in dsct cells by static stretch of the hind limb muscles, and the distributions of intervals between the impulses were computed. these distributions were essentially similar before and after impalement of the cells with the micropipette, suggesting that cell injury caused by penetration was insignificant. 3. patterns of syna ... | 1975 | 165283 |
| detection of oncornavirus antigenic activity in human urothelial tissues. | our studies indicate that certain urologic tissues demonstrate evidence of proteins which compete with the interspecies antigens of c-type ribonucleic acid viruses for binding sites of the feline and murine oncornavirus antiglobulins. this fact indicates either the association of viral antigens within these tissues or the presence of a protein so similar to the interspecies antigen that it cross reacts. studies are now underway to localize reacting antigens within these urologic cells, to correl ... | 1975 | 165323 |
| the glucagon receptor and adenylate cyclase. | acidic phospholipids play a critical role in the hormone activation of adenylate cyclase. solubilized myocardial adenylate cyclase is unresponsive to glucagon and the catecholamines, two of the hormones which activate the membrane-bound enzyme. phosphatidylserine, purified from bovine brain restored glucagon responsiveness of the solubilized adenylate cyclase. monophosphatidylinositol, also purified from bovine brain, restored catecholamine responsiveness. solubilized preparations of myocardial ... | 1975 | 165352 |
| lack of detectable change in cyclic amp during the cardiac inotropic response to isoproterenol immobilized on glass beads. | changes in contractility and the levels of adenosine 3':5'-cyclic monophosphoric acid (camp) were assessed in isolated cat cardiac muscle in response to soluble isoproterenol and isoproterenol immobilized on glass beads. drug-induced positive inotropic responses were compared to the maximum isometric force achieved with paired electrical stimulation, a potent physiological inotropic stimulus. isoproterenol (1 mum) in solution increased the force of contraction 0.832 plus or minus 0.165 g at 60 s ... | 1975 | 165489 |
| infectious spread and control of feline leukemia virus. | | 1975 | 165603 |
| glucagon and adenylate cyclase: binding studies and requirements for activation. | solubilization of myocardial adenylate cyclase abolished responsiveness to glucagon and catecholamines, two of the hormones which activate the membrane-bound enzyme. adenylate cyclase freed of detergent by deae-cellulose chromatography continues to remain unresponsive to hormone stimulation. however, adding purified bovine brain phospholipids--phosphotidylserine and monophosphatidylinositol--restored responsiveness to glucagon and catecholamines, respectively. 125-i-glucagon binding appeared to ... | 1975 | 165684 |
| hypothalamic cells in an area mediating acth release respond to right atrial stretch. | the right atrium has been shown to mediate release of acth in response to small hemorrhage. therefore, we sought to identify hypothalamic neurons (cat, alpha-choloralose 35-45 mg/kg) wholse firing rates were modulated by stretch of the right atrial-vena caval junction. stretch was produced by intermittent inflation of a balloon implanted between the pericardium and the right atrium. in some cases, carotid arteries were occluded bilaterally. previous results indicate that electrical stimulation o ... | 1975 | 165726 |
| actions of a new muscle relaxant (ah8165) on neuromuscular transmission. | the effects of a new muscle relaxant, ah8165, on miniature endplate potential (mepp) amplitude and frequency, endplate sensitivity to acetylcholine, and muscle twitch tension were studied in vitro in the frog sartorius muscle. nerve terminal effects were studied in vivo in the cat soleus muscle and its ventral root fibers. ah8165 stimulates the nerve terminal, as evidenced by increased mepp frequency and the appearance of post-drug repetitive activity. in the same concentration range at which me ... | 1975 | 165756 |
| a review of rem sleep deprivation. | studies on the behavioral consequences of rapid eye movement (rem) sleep deprivation in animals and humans are critically reviewed. in animals, converging evidence--some reasonably well controlled--indicates that rem sleep deprivation probably heightens central neural excitability and increased motivational behavior, but has nuclear or inconclusive effects on learning. in humans, evidence indicates that rem sleep deprivation is not dream deprivation and is not harmful to schizophrenic, depressed ... | 1975 | 165795 |
| nicotine-induced stimulation of steroidogenesis in adrenocortical cells of the cat. | 1. the effect of nicotine on steroid production and release from trypsin-dispersed cat adrenocortical cells was investigated. 2. nicotine, like adrenocorticotrophin (acth), elicited a dose-dependent increase in steroidogenesis, which depended upon the presence of calcium in the medium. 3. augmented steroid production evoked by submaximal concentrations of acth monobutyryl cyclic adenosine 3',5'-monophosphate (amp), or prostaglandin e2 was further enhanced by steroidogenic concentrations of nicot ... | 1975 | 165845 |
| [polygraphic study of sleep in dogs]. | phenomenology and structure of the dog sleep were studied in chronic experiments. three stages of nrem and rem phases were revealed. sleeep in the dog was shown to differ from sleep in the rat, rabbit, and cat by appearance of alpha-like regular rhythm 8--9/sec during the onset of drowsiness, and by the sigma-rhythm first appearing against the background of clear slow waves. the exact estimation of rem sleep was shown to need a combined consideration of the eeg data with one of the two other ... | 1975 | 165988 |
| interrelationship between corticosteroid production and fine structure in the fetal adrenal cortex. | | 1975 | 166011 |
| results of radiation treatment of naturally occurring animal tumors. | | 1975 | 166056 |
| an inherited disorder of persian cats with intracytoplasmic inclusions in neutrophils. | | 1975 | 166058 |
| effects of trigeminal tractotomy and of carbamazepine on single trigeminal sensory neurons in cats. | | 1975 | 166097 |
| release of norepinephrine and dopamine-beta-hydroxylase by nerve stimulation. iv. an evaluation of a role for cyclic adenosine monophosphate. | the effects of several cyclic nucleotide analogs and of phosphodiesterase inhibitors on the release of norepinephrine (ne) and dopamine-beta-hydroxylase activity (dbh) by electrical stimulation were studied in the isolated, perfused cat spleen. n-6-butyryl-3',5'-adenosine monophosphate (mbcamp), 8-methylthio-3',5'-adenosine monophosphate, 8-bromo-3',5'-guanosine monophosphate (8-br-cgmp) and two potent phosphodiesterase inhibitors: 1-methyl-3-isobutylxanthine and 4-(3-butoxy-4-methoxy-benzyl)-2- ... | 1975 | 166157 |
| cyclic adenosine-3',5'-monophosphate in cerebrospinal fluid during fever and antipyresis. | | 1975 | 166164 |
| comparative studies on the structural phosphoproteins of mammalian type c viruses. | the major phosphoprotein common to woolly monkey sarcoma virus, gibbon ape lymphosarcoma virus, and type c viruses of the lower mammalian species (mouse, rat, cat), with the exception of the endogenous cat virus (rd-114), is the polypeptide of about 12,000 molecular weight. the protein-phosphate bond in this polypeptide of several viruses is of the phosphoserine variety excepting gibbon ape virus, which contains both phosphoserine and phosphothreonine. the primary phosphoprotein of rd-114 virus ... | 1975 | 166200 |
| letter: gamma-aminobutyric acid in csf in schizophrenia. | | 1975 | 166315 |
| pharmacology of neural modulation and transmission. | | 1975 | 166405 |
| evidence for a possible prostaglandin link in acth-induced steroidogenesis. | the steroidogenic response to acth prostaglandin e2 (pge2) was studied in cat adrenocortical cells dispersed with trypsin. the dose-response curves of both agents were qualitatively and quantitatively similar. exposure to pge2 or acth in the presence of labeled steroid precursor (acetate) resulted in the accumulation of comparable levels of steroid intermediates and end-product. submaximal or maximal concentrations of acth and pge-2 given simultaneously elicited a response which was no greater t ... | 1975 | 166416 |
| differential host range of viruses of feline leukemia-sarcoma complex. | | 1975 | 166488 |
| amino-terminal sequence of baboon type c virus p30. | | 1975 | 166494 |
| autoradiographic identification of the cells accumulating 3h gamma-aminobutyric acid in mammalian retinae: a species comparison. | | 1975 | 166509 |
| experimental studies to determine application of cat scanning to the human body. | | 1975 | 166566 |
| the measurement of adenosine 3,5-monophosphate in bone. | | 1975 | 166572 |
| determination of the inter-spike times of neurons receiving randomly arriving post-synaptik potentials. | | 1975 | 166706 |
| rem sleep deprivation. | | 1975 | 166712 |
| [hypersomnia by isthmic lesion in cat. ii. neurophysiological and pharmacological study]. | (1) the bilateral destruction of the region of the dorsal norepinephrine bundle in the isthmus or in the mesencephalon induces a significant increase of both paradoxical sleep (ps) (up to 400%) and of slow-wave sleep (sws). the increase of ps lasts for 4-5 days while the increase of sws lasts at least 8-10 days. the same phenomenon is observed after total hypophysectomy. (2) control lesions effectuated in the isthmus outside the area of the dorsal norepinephrine bundle do not affect significantl ... | 1975 | 166726 |
| a study of inhibitory antagonism in cat visual cortex. | since there seems to be good evidence that gaba may act as an inhibitory neurotransmitter in the mammalian cortex, we tested the effects of an antagonist of gaba, namely the alkaloid bicuculine, on the response properties of visual cortex neurons, using a computer-controlled stimulus presentation system to assess quantitatively the changes in receptive field organization after the drug. complex cells were most affected, increasing both evoked and spontaneous activity and losing some of their spe ... | 1975 | 166731 |
| comparative pharmacological studies on butriptyline and some related standard tricyclic antidepressants. | butriptyline was compared with imipramine and other tricyclic antidepressants for its ability to modify: (a) contractions of the cat nictitating membrane induced by noradrenaline (na) and 5-hydroxytryptamine (5-ht), (b) the adrenergic neuron blocking action of guanethidine in the guinea pig vas deferns, (c) the rabbit's electroencephalogram (eeg) and physostigmine arousal, and (d) the sleep pattern of the rat. imipramine and amitriptyline potentiated the na and 5-ht effects on the nictitating me ... | 1975 | 166748 |
| [phylogenetic study of hepatic microsomal glucokinases]. | | 1975 | 166791 |
| neurohumoral correlates of sleep: increase of proteins during rapid eye movement sleep. | | 1975 | 166859 |
| the action of mercury ions on the release of acetylcholine from presynaptic nerve endings. | | 1975 | 166868 |
| epidemiological studies on feline leukaemia virus infection. i. a serological survey in urban cats. | a survey of the incidence of feline leukaemia virus (felv) infection in cats in a large urban area was made by studying the prevalence of antibodies to feline leukaemia virus-associated cell membrane antigens. two serological tests were used, immunofluorescence and a mixed immunoglobulin rosette technique. the overall incidence of cats with antibodies was 40%, contrasting with 6% in the surrounding rural area. only 6% of urban kittens were positive while 50% of adults had antibodies. the inciden ... | 1975 | 166947 |
| isolation of a unique peptide inhibitor of hormone-responsive adenylate cyclase. | we have perfused isolated rat livers with hypocalcemic (4.4 mg 100 ml) krebs-ringer bicarbonate albumin buffer. after 15 min of perfusion, a substance appeared in the perfusate which decreased rat renal adenylate cyclase activation by parathyroid hormone (pth). the material in the perfusate was purified greater than 50,000-fold by bio-gel p-10 chromatography. the purified antagonist decreased the activation of rat renal cortical adenylate cyclase by pth, glucagon, and epinephrine 75 to 100%. con ... | 1975 | 167024 |
| the third circulation revisited. | the author reviews modern information concerning the formation, flow and functions of the cerebrospinal fluid. particular attention is given to the lymphatic-like features of the third circulation and to its importance as an internal milieu for nervous tissue. | 1975 | 167134 |
| two populations or granular vesicles in constricted post-ganglionic sympathetic nerves. | 1. a comparative study has been made of the effects of different fixatives on the ultrastructural appearance of granular vesicles accumulated against a constriction in cat hypogastric nerves. 2. after fixation in either osmium tetroxide or in glutaraldehyde followed by post-osmication accumulations of large granular vesicles (65-90 nm in diameter) were observed in profiles of swollen axons. 3. fixation in acrolein and sodium dichromate revealed a second population of small granular vesicles (mos ... | 1975 | 167158 |
| preservation of early discharge of muscle afferents in acrylamide neuropathy. | 1. responses to stretch and the 'early discharge' have been studied in acrylamide neuropathy in the expectation that functional block of the nerve terminals would allow these two processes to be dissociated. 2. of 538 single group i and group ii muscle afferents which were nonresponsive to stretch, ninety-nine displayed 'early discharge' which appeared to be identical with that described in normally functioning muscle stretch afferents. 3. preservation of 'early discharge' in non-responsive fibr ... | 1975 | 167161 |
| morphology and biochemistry of small, intensely fluorescent cells of sympathetic ganglia. | | 1975 | 167287 |
| proceedings: effect of analgesics on excitation of afferent cardiac sympathetic nerve fibers during myocardial ischaemia and after intracardial injection of bradykinin. | | 1975 | 167296 |
| neurochemical aspects of post-tetanic potentiation of monosynaptic reflexes in the cat spinal cord. i. analysis of amino acids at maximum of potentiation. | in order to determine the chemical changes which might occur during post-tetanic potentiation, amino acids from the motor regions of the ventral horn of the spinal cord (potentiated and unpotentiated sides) of 10 different cats were analyzed. the intermittent tetanic stimulation of the nn. gastroc. (only on the potentiated side) was carried out until a maximum of potentiation was reached (3--4 min). the monosynaptic reflexes were obtained from the ventral roots (l7 or s1) of both sides. the amin ... | 1975 | 167318 |
| functional differentiation of splanchnic a delta fibres in relation to viscerosomatic reflexes. | the splanchnic afferent signal in the myelinated fibre spectrum was analysed in cats and its relationship to viscerosomatic reflex activity was studied. in addition to abeta and adelta components, a further elevation was observed in the sympathetic chain neurogram. according to the conduction rate (15 plus or minus 4 m/sec), it was caused by myelinated fibres 2-3 mu in diameter. the presence of this component at thoracic dorsal root level, or in the sympathetic chain in stimulation of the postga ... | 1975 | 167390 |
| relationship between the activity of postsynaptic spinal cord elements and propriospinal and spino-bulbo-spinal reflexes. | the relationship between the activity of the lumbar spinal interneurones and propriospinal (ps) and spino-bulbo-spinal (sbs) efferent reflex responses evoked by somatic (muscle, skin) and splanchnic nerve stimulation was studied in chloralose-anaestetized adult cats. during stimulation of one somatic nerve, the postsynaptic cord elements could be divided into three groups, according to whether their activity was was synchronous with the ps component of the efferent discharge (ps group), with the ... | 1975 | 167391 |
| [research on the spontaneous unitary activity of corticofugal neurons in the sensomotory area of the cat during sleep-wakefulness cycle. 2. cortico-red neurons]. | | 1975 | 167417 |
| changes in protein levels in perfusates of freely moving cats: relation to behavioral state. | perfusates from the brains of freely moving cats, obtained by means of a push-pull cannula, contain high concentrations of proteins. the levels vary in a cyclic fashion and are higher during rapid eye movement sleep than during the waking state. the proteins represent a distinctive class of tissue protein and their changing levels appear to reflect an alteration in the protein content of the extracellular space of brain related to behavioral state. | 1975 | 167436 |
| newer knowledge in comparative virology--its contribution to human health research. | like other comparative sciences, and despite its recent beginning comparative virology has already contributed useful applications and observations to human health research. teachings derived from the study of marek's disease found application in that of burkitt's lymphoma, and may lead to a possible vaccine against the human disease. equally useful information came from the study of canine distemper in the development of a chorio-allantoic membrane attenuated measles vaccine, and in our knowled ... | 1975 | 167504 |
| efficient release of murine xenotropic oncornavirus after murine leukemia virus infection of mouse cells. | | 1975 | 167521 |
| [influence of age on eeg changes in epileptic patients]. | | 1975 | 167527 |
| effects on the ventral spinocerebellar tract neurones from deiters' nucleus and the medial longitudinal fascicle in the cat. | effects from the vestibulospinal tract (vst) and from fibres descending in the medial longitudinal fascicle (mlf) on the cells of origin of the ventral spinocerebellar tract (vsct) have been studied with intracellular recording. out of 110 vsct neurones, the vst evoked monosynaptic epsps in 27, di- or polysynaptic epsps in 56 and disynaptic ipsps in 26. in 93 tested vsct cells, mlf stimulation evoked monosynaptic epsps in 26, monosynaptic ipsps in 2, di- or polysynaptic epsps in 25 and disynapti ... | 1975 | 167549 |
| the action of dibutyryl adenosine-3':5'-cyclic monophosphoric acid and theophylline on the isolated cat parotid gland. | in the isolated cat parotid gland intraarterially applied dibutyryl cyclic amp (db-camp) (1.0 mm) produced a slow, but often maintained salivary flow. db-camp was also able to potentiate secretion evoked by supramaximal doses of intraarterially applied acetylcholine. similar secretory effects were obtained also after intraarterial application of theophylline (1.0 mm). the secretory responses due to db-camp or theophylline were unaccompanied by measurable acinar membrane potential changes and sta ... | 1975 | 167551 |
| (na+ + k+)-activated adenosinetriphosphatase: fluorimetric determination of the associated k+ -dependent 3-o-methylfluorescein phosphatase and its use for the assay of enzyme samples with low activities. | | 1975 | 167602 |
| an updated listing of animal reference virus recommendations. | | 1975 | 167622 |
| an unusual case of feline leukemia and an associated syncytium-forming virus. | a 3-year-old female siamese cat was admitted to a local animal hospital with a history of recent extreme lethargy and anorexia. a hemorrhagic tumor was removed from an area of oral buccal skin and diagnosed histopathologically as lymphosarcoma. rapid physical deterioration occurred, and the cat became moribund 2 weeks after surgical operation. necropsy revealed at least 200 spherical hemorrhagic neoplastic nodules attached to the omentum, mesentery, and peritoneum. examination of histopathologic ... | 1975 | 167623 |
| [myrianthus sp. (pal.-beauv.) of the ivory coast, cough suppressants]. | | 1975 | 167645 |
| neuroregulators and sleep mechanisms. | information which has emerged thus far relates to the overall transmitter mechanisms of sleep. the data, while conflicting, point to the involvement of many neuroregulators at numerous integrative levels of the process. however the long term question still remain: what triggers and maintain sleep, what stops sleep, what occurs to the body and brain during sleep--in essence, why sleep? these questions are now problems for behavioral neurochemists, whereas in a previous era, they were problems for ... | 1975 | 167654 |
| effects of chlorpromazine and diazepam on neuronal activities of the lateral vestibular nucleus in cats. | the effects of chlorpromazine and diazepam on vestibular neuronal activity were studied in gallamine immobilized cats. chlorpromazine depressed all the p, n1 and n2-waves of field potentials in the lateral vestibular nucleus evoked by electrical stimulation of the vestibular nerve. diazepam also reduced the amplitude of postsynaptic components (n1 and n2-waves), while the presynaptic one (p-wave) was slightly increased. chlorpromazine suppressed the spontaneous as well as the increased vestibula ... | 1975 | 167697 |
| radio-enzymatic assay of acetylcholine in tissues. | | 1975 | 167790 |
| proceedings: changes in respiratory pattern accompanying sleep in cats. | | 1975 | 167891 |
| proceedings: cyclic adenosine-3', 5'-monophosphate in cerebrospinal fluid. | | 1975 | 167896 |
| an immunoprecipitin study of the incidence of influenza a antibodies in animal sera in the ottawa area. | a survey of over 600 'normal' sera from 14 animal species by immunoprecipitin tests in cellulose acetate using viron antigens revealed a high incidence of precipitating activity against a broad range of influenza a virus strains, particularly a2hhong kong/1/68 and /pr8. however, serum treatments trypsin-heat-periodate, naio4, v. cholerae receptor-destroying enzyme (rde), or kaolin eliminated most precipitating activity, which suggests that it was due to "non-specific" inhibitors of influenze vir ... | 1975 | 167931 |
| the current status of prostaglandins and the lungs. | the prostaglandins are a group of pharmacologically potent lipid compounds whose role in pulmonary pathophysiology remains to be defined. there is not question that these compounds can induce constriction (pgf) or relaxation (pge) of the smooth muscle in bronchi and pulmonary vessels. there is no question that the lungs are a major site of both the synthesis and degradation. these facts make speculation about the role of the prostaglandins in pulmonary disorders a tempting exercise. however, the ... | 1975 | 168038 |
| effects of temperature on interictal discharge at penicillin epileptogenic foci. | the effects of local brain temperature on acute focal penicillin epilepsy in the exposed hippocampus of cat were studied. results from anesthetized and from immobilized, unanesthetized animals were compared. over the temperature range 26 to 43 degrees c (at the alveus), the interictal spike interval and duration of the spike discharge varied inversely with temperature. the former showed a q10 of 2.4 and the latter a q10 of 1.5, with no difference due to type of preparation. a significant trans-h ... | 1975 | 168063 |
| central and peripheral contribution to the antihypertensive action of indoramin. | indoramin has been reported to reduce blood pressure in experimental animals and humans. the complex pharmacological profile of the compound suggests that it may also exert central actions. effects on spontaneous sympathetic outflow and on sympathetic nerve and blood pressure responses to hypothalamic stimulation were examined in anesthetized cats in the present study. at a low dose (1 mg/kg) indoramin reduced blood pressure but did not significantly influence the level of efferent sympathetic n ... | 1975 | 168091 |
| the pharmacology of the inhibition of dorsal horn neurones by impulses in myelinated cutaneous afferents in the cat. | the effects of microelectrophoretic strychnine and bicuculline methochloride were studied on the time course of synaptic inhibitions of single dorsal horn neurones in the lumbar spinal cord of cats anaesthetized with pentobarbitone. the inhibitions, evoked by volleys in mixed myelinated cutaneous afferents, varied in latency and duration. in general, early inhibitions (latency less than 12msec; duration less than 36 msec) were reduced by microelectrophoretic strychnine whereas late inhibitions ( ... | 1975 | 168096 |
| presynaptic action of beta(4-chlorophenyl)-gaba. | | 1975 | 168097 |
| watery diarrhea associated with pancreatic islet cell carcinoma. | a patient with severe watery diarrhea and a non-beta islet cell carcinoma of the pancreas producing five hormones (secretin, serotonin, enteroglucagon, vasoactive intestinal polypeptide, and pancreatic glucagon) is described. we have demonstrated massive pancreatic hypersecretion to be a major factor in this patient's diarrhea. possible inter-relationships of the actions of five hormones present in excess in the patient are discussed. | 1975 | 168118 |
| extracellular potassium changes in the spinal cord of the cat and their relation to slow potentials, active transport and impulse transmission. | 1. by means of k-specific double-barrelled micro-electrodes the time course of changes in k+ concentration in the extracellular space of the lumbar spinal cord was examined after peripheral tetanic stimulation and after a single volley in a mixed peripheral nerve in non-anaesthetized, intercollicularly decerebrated and spinalized cats. 2. tetanic stimulation (100 hz) which increases the [k]e from 3 to 9 mm is followed by a phase of reduced [k]e during which [k]e decreases by 0.5 mm below resting ... | 1975 | 168359 |
| proceedings: cyclic adenosine 3'-5'-monophosphate (camp) and body temperature. | | 1975 | 168360 |
| proceedings: facilitation of the tonic vibration reflex in the spinal cat by 5-hydroxytryptophan (5-htp). | | 1975 | 168362 |
| depression in the excitability of relay cells of lateral geniculate nucleus following saccadic eye movements in the cat. | 1. the excitability of relay cells of the lateral geniculate nucleus during a saccadic eye movement was studied in alert cats. excitability was assessed by the firing probability of the cells in response to electrical stimulation of the optic chiasm. modifications in the excitability were evaluated during the period following eye movements, by triggering a stimulator from potential shifts in electro-oculogram and altering delays in the stimulus pulse. 2. the cells were classified into s and t ce ... | 1975 | 168363 |
| structure, subunit composition, and molecular weight of rd-114 rna. | the properties and subunit composition of the rna extracted from rd-114 virions have been studied. the rna extracted from the virion has a sedimentation coefficient of 52s in a nondenaturing aqueous electrolyte. the estimated molecular weight by sedimentation in nondenaturing and weakly denaturing media is in the range 5.7 x 10(6) to 7.0 x 10(6). by electron microscopy, under moderately denaturing conditions, the 52s molecule is seen to be an extended single strand with a contour length of about ... | 1975 | 168408 |
| participation of mono- and polysynaptic transmission during tonic activation of the stretch reflex arcs. | through intracellular observations of the cat spinal motoneuron both mono- and polysynaptic reflex arcs were shown to participate in repetitive activation of stretch reflex. experiments were performed on 25 cats anesthetized by intraperitoneal (i.p.) injection of 3 cc/kg of a mixture of 1% chloralose and 10% urethane. driving of the motoneuronal discharges accomplished by electric stimulation (16-100 hz) of the gastrocnemius lateralis and medialis nerves. repeated electric stimulation of muscle ... | 1975 | 168423 |
| the perfused adrenal gland. | | 1975 | 168466 |
| effects of ketamine on synaptic transmission in cat spinal cord. | | 1975 | 168509 |
| pharmacological studies on 2- and 4-pyridylethylamides of acetyltropic acid (pat-2 and pat-4). | two new compounds: 2- and 4-pyridylmethylamides of acetyltropic acid (pat 2 and pat-4) show spasmolytic effects on isolated guinea pig ileum, have mydriatic actevity in rabbits and block restraint produced ulceration in rats. pat-4 causes a strong inhibition of the salivary secretion in mice. both of the test compounds inhibit also the effects of ach and vagus stimulation on the blood pressure and have local anaesthetic activity. pat-4 inhibits the aggressive behaviour in mice and rats, prolongs ... | 1975 | 168562 |
| mechanism of action of psychotomimetic drugs. | | 1975 | 168609 |
| [an atypical case of aujeszky's disease in a dog (author's transl)]. | two cases of aujeszky's disease in a cat and a dog belonging to the same owner are reported. the two animals each were five months of age. the symptoms shown by the cat were typical of aujeszky's disease: intense itching, salivation and the head bent to one side. the main symptoms shown by the dog consisted in salivation, ptosis of one eye, a drooping ear, the head bent to one side and ataxia. as itching was not observed in the dog and the animal had spent the first months of its life in wooded ... | 1975 | 168663 |
| [one aspect of evolutionary pharmacology. oligomerization of cholinoreceptors during development of the animal kingdom]. | | 1975 | 168702 |
| studies on the growth of feline panleukopaenia virus in cell cultures. | the growth of feline panleukopaenia virus was examined in relation to various cell growth curves of secondary feline kidney cells. in cell cultures with a high mitotic index, the manifestation of virus infection, expressed as percentage number of cells with inclusion bodies, was correspondingly high. in cultures with low mitotic index, the percentage number of cells with inclusion bodies was low. a cytopathic effect was seen by inoculation of virus with a titre of 10-3-5tcid-50/ml. this effect w ... | 1975 | 168729 |
| some aspects of the electroanatomy of dendrites. | an understanding of the neuronal function requires the knowledge of the electroanatomy of dendrites, which comprise the major area and receive the main input in most neurons. some simplifying assumptions are necessary to describe the electrical characteristics of the dendritic tree. the applicability of the simplified model of a combined equivalent dendritic cylinder proposed by rall, was tested and verified by a combined analysis of anatomic and electrical data from the same spinal motoneurons. ... | 1975 | 168754 |
| ddt and related chlorinated hydrocarbon insecticides: pharmacological basis of their toxicity in mammals. | | 1975 | 168756 |
| norepinephrine vascoconstrictor escape in isolated meseneric arteries. | when isolated superfused cat mesentric arterial rings were exposed to norepinephrine(ne) 10'-6 g/ml, force initially increased but subsequently declined despite continuedadministration of ne. phasic contractions occurred in 48% of the vessels. norepinephrine concentrations just above threshold induced tonic contractions without escape. when ne was administered after brief exposure of the arterial rings to low-calcium solutions, peak force development and escape were both reduced and phasic co ... | 1975 | 168781 |
| phosphodiesterase inhibitors and cerebral vasospasm. | experimental cerebral vasospasm was studied in cat and monkey models. in the cat, the basilar artery was exposed by a transclival approach and spasm induced by the application of blood to the vessel. in the monkey, spasm was produced by injecting blood into the subarachnoid space. vessel size was determined in the cat by direct observation and, in the monkey, by cerebral angiography. several agents known to alter the synthsis and degradation of cyclic adenosine monophosphate (amp) were used to m ... | 1975 | 168844 |
| the relation of hippocampal theta activity to arousal, attentive behaviour and somato-motor movements in unrestrained cats. | eeg recordings of hippocampal theta activity and neocortical activity were correlated with direct observations and photographic recordings of the behaviour of unrestrained cats. the behaviour studied included (1) both spontaneous and induced changes in level of arousal (sleep-wakefulness), (2) different types of orienting activity that occur as the animal is repeatedly exposed to a novel environment, and (3) activities such as walking, drinking, and grooming. with increases in arousal, amount of ... | 1975 | 168940 |
| a biochemical and genetic analysis of mammalian rna-containing sarcoma viruses. | current studies have shown that all mammalian sarcoma-producing viruses, whether isolated from laboratory experiments of naturally occurring tumors, are deletion mutants of replicating mammalian type c viruses. nonproducer cells transformed by any of these sarcoma viruses contain rna homologous to mammalian leukemia viruses, even though the cells contain no known proteins currently coded for by the mammalian leukemia virus. this mammalian leukemia virus information (ft-) is a genetically stable ... | 1975 | 169043 |
| supersensitivity to catecholamines after impairment of extraneuronal uptake or catechol-o-methyl transferase. | in cat papillary muscle and nictitating membrane block of extraneuronal catechol-o-methyl transferase (comt) by 3',4'-dihydroxy-alpha-methyl propiophenone (u-0521) or of extraneuronal uptake by hydrocortisone causes supersensitivity to catecholamines whenever the experimental conditions result in a high sensitivity of the organ to catecholamines. after block of monoamine oxidase the extraneuronal o-methylation of (-)-[3h]norepinephrine by the isolated nictiating membrane is due to two o-methylat ... | 1975 | 169167 |
| [studies on the mechanism of the diabetogenic activity of streptozotocin and on the ability of compounds to block the diabetogenic activity of streptozotocin (author's transl)]. | the present study was undertaken to clarify the mechanism of the diabetogenic activity of streptozotocin. experiments were conducted to determine the resistance of animals to the diabetogenic action of streptozotocin; to follow the time course of irreversible beta-cell damage, and to determine the influence on streptozotocin action of certain compounds. streptozotocin, a broad spectrum antibiotic, with antitumoral properties, was shown to be diabetogenic in rats and mice, but not in cats, rabbit ... | 1975 | 169168 |
| amino acid sequence homology of mammalian type c rna virus major internal proteins. | the nh2-terminal amino acid sequence of the major group-specific antigen, the major internal virion protein (p30; approximate molecular weight 30,000) of several mammalian type c rna viruses was determined by the edman degradation procedure using an automated protein sequenator. all of the proteins analyzed show a high degree of over-all sequence homology and also contain specific regions or single residues. all p30s begin with the sequence prolyl-leucylarginyl (pro-leu-arg) and have an invarian ... | 1975 | 169234 |
| quantitative histochemistry of gamma-aminobutyric acid in cat spinal cord with special reference to presynaptic inhibition. | | 1975 | 169322 |
| letter: methyl n-butyl ketone. | | 1975 | 169334 |
| establishment of two canine sarcoma cell lines: productive infection with feline leukemia virus. | two canine sarcoma cell lines (11028, 11031) were established in vitro and have been transferred 213 and 306 times, respectively, since 1970. these cell lines had a chromosome pattern consistent with their canine origin. both cultures were infected with feline leukemia virus (felv), which caused a morphologic and karyotypic changes. the cells became rounded after infection with felv and both cultures showed the presence of a single, large, acrocentric chromosome considered to be a marker chromos ... | 1975 | 169374 |
| feline oncornavirus-associated cell membrane antigen. iv. antibody titers in cats with naturally occurring leukemia, lymphoma, and other diseases. | cats with naturally occurring leukemia and lymphoma had low or negative humoral antibody titers to the feline oncornavirus-associated cell membrane antigen (focma). geographic differences were seen in the relative frequencies of various forms of lymphoproliferative neoplasms. lymphatic leukemia and thymic lymphoma were most common in boston, whereas alimentary lymphoma was most frequent in glasgow. no significant differences were found in geometric mean focma antibody titers for the various form ... | 1975 | 169377 |
| doxepin and imipramine: effect on catecholamine inhibition of ganglionic transmission. | | 1975 | 169449 |
| editorial: leukaemia in animals and man. | | 1975 | 169460 |
| viral leukaemia in domestic cats. | | 1975 | 169461 |
| [effects of alpha-methyl-dopa on new born kitten sleep. behavioral evolution during the first month post-birth (author's transl)]. | the paradoxical sleep (ps)-suppressing effect of alpha-methyl-dopa was studied in kittens at birth. the new burn animal received daily injections of alpha-methyl-dopa during the 2 first weeks of life. states of sleep were studied during the treatment (days 1 to 14) and after administration of the drug way halted (days 15 and 16). daily injections of alpha-methyl-dopa induce an average ps-deprivation of 72%. this deprievation is compensated for by a significant increase in quiet sleep (qs)-rate w ... | 1975 | 169537 |
| the search for the chemistry of memory: recent trends and the logic of investigation in the role of cholinergic and adrenergic transmitters. | | 1975 | 169545 |
| [cathecholamine in heart failure (author's transl)]. | | 1975 | 169560 |
| [the incidence of lymphosarcoma (leukaemia) and feline leukaemia virus (felv) in cats in the netherlands (author's transl)]. | seven different groups of cats were examined to study the incidence and distribution of feline leukaemia virus (felv) in the netherlands. the indirect fluorescent antibody (ifa) technique was used to detect felv antigen. of the cats with lymphosarcoma (leukaemia), 73.2 per cent and of those with infectious peritonitis, 32.4 per cent were found to be positive for felv antigen. of the sixty-six cats with other tumours, only one, a cat with carcinoma of the mammary gland; was positive for felv anti ... | 1975 | 169604 |