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proceedings: the inhibitory effects of muscle spindle primary afferents investigated by the afferent triggered averaging method. 1975125327
proceedings: the post-stimulus histogram as an analogue of post-synaptic potentials in fusimotor neurones. 1975125328
skeleto-fusimotor axons in the hind-limb muscles of the cat.1. motor axons supplying various hind-limb muscles of the cat (flexor hallucis lingus, peroneus brevis, peroneus digiti quinti, tibialis anterior, soleus and tenuissimus) were identified as skeleto-fusimotor or beta axons because their repetitive stimulation elicited both the contraction of extrafusal muscle fibres and an increase in the rate of discharge of spindle primary endings which perisited after selective blockade of extrafusal neuromuscular junctions. 2. the conduction velocity of these ...1975125329
correlation of the dynamic behaviour of deefferented primary muscle spindle endings with their static behaviour.20 deefferented primary muscle spindle endings, 8 afferents from the extensor digitorum longus muscle (edl) and 12 from the tibialis anterior muscle (ta), were investigated in 12 anesthetized cats. dynamic responses of muscle spindles to ramp stretches were correlated with their static responses. the variation in the state and dynamic behaviour was found to be interdependent. the correlation coefficients were higher for edl spindles than for ta spindles. the correlation coefficients depended upo ...1975125408
prophylactically administered phenytoin. effects on the development of chronic cobalt-induced epilepsy in the cat.in chronic cobalt-induced experimental epilepsy in the cat, there are alterations in behavior, electroencephalograms, and brain sodium, potassium adenosine triphosphatase (na,k atpase) activity. the electrographic and enzymatic changes occur both in focus and homotopic cortex, and are time related. the onset of eeg paroxysms consistently precedes increases in na,k atpase activity, indicating that the enzymatic change is adaptive. prophylactic treatment with phenytoin (formerly diphenylhydantoin) ...1975125575
proceedings: reflex control of expiratory airflow and duration. 1975125617
regional distribution of choline acetyltransferase in the human brain: changes in huntington's chorea.a stereotaxic method of tissue sampling has been developed permitting detailed studies of the distribution of choline acetyltransferase (cat) in brains from controls and from patients suffering from huntington's chorea. the characteristic pattern of cat distribution within extra-pyramidal structures is described. in huntington's chorea, cat is unevenly reduced in several brain regions particularly in the rostromedial part of the caudate nucleus. the results indicate a preferential degeneration o ...1975125784
afferent-efferent linkages in motor cortex for single forelimb muscles.1. in locally anesthetized cats, extracellular recordings were made from single neurons in the lateral cruciate gyrus of cerebral cortex. these neurons responded to natural activation of stretch receptors in single, contralateral, forelimb wrist muscles, typically with phasic excitation. low-velocity stretches, which activate primary endings of muscle spindles, excited one set of neurons at a mean latency of 11 ms; high-velocity stretches, which principally activate golgi tendon organs and/or se ...1975125786
[functional survival of the human corti organ after dissection of the eight nerve (author's transl)].the behaviour of the functional unit haircell - peripheral neurit before and after the dissection of the cochlear nerve in two cases of cerebello-pontine angle tumors is described. an immediate alteration does not seem to be found when the blood supply via internal acoustic meatus is not severed. the survival time after the dissection of the acoustic nerve is somewhat more than seven weeks. this is longer than related morphological findings indicate in the cat where the morphological survival ti ...1975125829
myosin from fast and slow skeletal and cardiac muscles of mammals of different size.the atpase activity of myosin and contraction time in extensor digitorum longus muscle, soleus muscle and cardiac muscle was compared in mammals differing in size. it was shown that the myosin atpase activity of homologous muscles decreases and contraction time increases with increasing size of animals. the rate of tryptic digestion of myosin, the electrophoretic pattern of light chains of myosin and the effect of p-chloromercuribenzoate on atpase activity of myosin were also studied. all these ...1975125884
histochemical and neurophysiological studies of autotransplanted cat muscle.free autologous transplants of previously denervated whole muscles in adult cats were studied with histochemical and electromyographical methods. the transplants were placed in contact with normal intercostal muscles in intercostal spaces and removed at intervals from 5 days to 44 weeks after transplantation. normal muscles as well as transplanted muscles without previous denervation and muscles denervated and left in situ were also studied.. the fibres of the previously denervated grafts surviv ...1975125919
control of depth and frequency of breathing during baroreceptor stimulation in cats.in 10 tracheotomized anesthetized cats during steady-state inhalation of various concentrations of co2 and o2, the acute respiratory response to baroreceptor stimulation produced by transient inflation of a balloon placed in the descending aorta was studied. the latter induced a sudden rise in mean arterial pressure, ranging from 62 to 95 mmhg. at all paco2 levels above 30 mmhg, elevation in arterial pressure was accompanied by an immediate drop in tidal volume (vt) and prolongation of the durat ...1975126222
[spindle sensitivity in the elevator muscles, canine intercuspidation and mandibular rest position. study in the cat]. 1975126230
proceedings: "static" and "dynamic" nuclear bag fibres in isolated cat muscle spindles. 1975126318
[evaluation of myocardial efficiency. principles of muscular physiology and methodological problems]. 1975126351
dissociation of the positive inotropic effects from the cardiotoxic effects of digitalis. 1975126454
effects of p-chlorophenyl alanine on brain amines and drugs induced sleep. 1975126455
studies on the cardiac glycoside inotropic receptor. 1975126458
the thrombocytolytic activity of bacterial peptidoglycans.the peptidoglycan of group a streptococcus prepared by hot formamide or tca extraction has an expressive ability to lyse rabbit blood platelets in vitro. initial changes in the ultrastructure of platelets can be observed after 10 minutes incubation of rabbit platelets with 0.1 mug of streptococcus peptidoglycan per ml. the submicroscopic alterations are characterized by changes of the shape and damage of the limiting membrane of the platelets. larger amounts of peptidoglycan (10 mug/ml and more) ...1975126559
potential clinical uses of short-acting nondepolarizing neuromuscular-blocking agents as predicted from animal experiments.it is readily evident that a short-acting nondepolarizing agent suitable for clinical use would be of value in anesthesiology. the most commonly used short-acting relaxant, succinylcholine, is a depolarizing drug, with all the side effects inherent in such agents. the authors have investigated the actions of several short-acting nondepolarizing ester neuromuscular-blocking drug in comparison with succinylcholine, and theri interactions with d-tubocurarine, and inhibitors of true and plasma choli ...1975126651
[some regularities of the regeneration of the musculature of internal organs].the paper summarizes the data of the author and his co-workers on regulation of the musculature of vessels, digestive tract, uterus, ureters and urinary bladder. the smooth muscle cells have different degrees of differentiation. the muscular tissue of the vessels is most differentiated. the uterus musculature is very plastical. after injury mature myocytes are the first to undergo destruction. the intermedial substance is more stable. myoblasts, young elements of the fibroblast row and the suben ...1975126673
[effects of combination alfaxalone and alfadolone, anesthetic derivatives of pregnanedione, on cerebral hemodynamics in cats].intravenous injection of ct 1341 (a mixture of alphaxalone and alphadolone dissolved in cremophor el) induced a decrease in cerebral blood flow (cbf) measured by 133xe clearance in cats with artificial respiration (the mean reduction in cbf was 2 ml/100 g/mn for 1,2 mg/kg or ct 1341. so, cbf was decreased by 22% when ct 1341 (7,2 mg/kg) was intravenously injected, (mean pa co2 equals 30 mm hg). changes in cbf following ct 1341 intravenous injection seems to be caused by cerebral vascular constri ...1975126719
[changes in reactivity of rat visual system during wake-sleep cycle].the changes in amplitude of primary responses evoked at cortical level by paired pulses delivered into the optic nerve, have been statistically compared during seven stages of sleep and wakefulness. results are in agreement with changes in reactivity observed by other authors in the cat; an unexpected but significant decrease in reactivity has however been obtained during eyemovements when compared with other periods of paradoxical sleep.1975126727
[preliminary data on the origin of splanchnic nerve afferent fibers with respiratory influence].electrical stimulation of threshold branches beyond the celiac ganglion in lightly anesthetized cats results in phrenic nerve responses of two kinds. the anterior branches are inhibitory. the inferior branches are excitatory. the significance of the results are discussed in relation with visceral afferent nerve pathways.1975126754
effects of skin cooling on stretch reflex activity in triceps surae of the decerebrate cat. 1975126869
locomotor activity and speed of movements in relation to monoamine-acting drugs. 1975126971
role of mitochondrial calcium metabolism in the altered contractility of pressure-hypertrophied right ventricular myocardium.pressure-hypertrophied right ventricular myocardium (rvh) demonstrates paradoxically increased oxygen consumption (mvo2) related to increase- in vitro energy-linked mitochondrial calcium flux. the present experiments were designed to measure mitochondrial ca retention in intact rvh and relate changes in mitochondrial ca metabolism to altered rvh contractility and relaxation. sixteen cats were pulmonary artery banded and their hearts plus paired controls were perfused with 45ca-labeled krebs-hens ...1975127354
cardiac effects of ethacrynic acid, a na+, k+-atpase inhibitor.to test hypotheses relating positive inotropic effects of cardiac glycosides (cg) to inhibitory effects on na,k-atpase, cardiac actions of other inhibitors were examined. ethacrynic acid was studied using microelectrode recordings of dog purkinje fibers (dp) and cat papillary muscle (cp), and isometric recordings of cp at lmax stimulated at 1/sec (36.5 degrees c). results with all doses (20-200 gamma/ml) were similar, differing only in latency. actions of ethacrynic acid on electrical activity o ...1975127358
the malformations of the urinary system in autosomal disorders.data from the world literature about the pathology of the urinary system in autosomal chromosomal disorders are analyzed and compared with our own morphological investigations of this system in 63 cases of chromosomal disorders (patau's, edwards', down's, orbeli's, wolf-hirschhorn's syndromes, partial trisomy b and inversion of chromosome 2). the urinary system is most frequently involved in "cat-eye", triploidy, orbeli's, patau's and edwards' syndromes. all known malformations of the urinary sy ...1975127413
small-signal analysis of the encoder mechanism in the lobster stretch receptor and the frog and cat muscle spindle. 1975127626
proceedings: cardiovascular responses of the anaesthetized cat to lower body negative pressure. 1975127635
evidence for functionally independent control of intrafusal muscle spindle fibers by static and dynamic fusimotor fibers. 1975127647
impulse activity and receptor potential of primary and secondary endings of isolated mammalian muscle spindles.1. an isolated muscle spindle preparation from a tail muscle of cat is described. the afferent response to a ramp-and-hold stretch was recorded in individual axons from identified primary and secondary endings. 2. primary endings exhibit a prominent dynamic response, including an initial burst. they also show a well-maintained static discharge. secondary endings also show a well-sustained static discharge but generally have a much lower dynamic sensitivity. the response of primary and secondary ...1975127835
the influence of adrenergic effectors on the cationic pump of brain cell membrane. 1975128166
[proceedings: the effect of volume and pressure-induced myocardial hypertrophy on mitochondrial metabolism and contractility]. 1975128229
[proceedings: characterization of the sarcoplasmic reticulum in human non-ischemic heart diseases]. 1975128245
erythrocyte enzyme activities and glutathione levels of the horse, cat, dog and man. 1975128434
the effects of fusimotor stimulation during small amplitude stretching on the frequency-response of the primary ending of the mammalian muscle spindle.single fusimotor fibres to the de-efferented soleus of the anaesthetized cat were stimulated repetitively while recording the response of single primary afferents to small amplitude sinusoidal stretching at frequencies of 0-5--500 hz. the response of the ending was determined by averaging its firing for many cycles to construct a 'cycle histogram'. when small enough, the stretching modulated the firing sinusoidally; as the frequency increased the requisite amplitude fell to a fraction of a micro ...1975128457
[responses of the muscle spindles of denervated muscles to mechanical stimulation]. 1975128471
proceedings correlation between ultrastructure and histochemistry of mammalian intrafusal muscle fibres. 1975128624
cinematographic analysis of contractile events produced in intrafusal muscle fibres by stimulation of static and dynamic fusimotor axons.1. muscle spindles with an intact blood supply and uninterrupted connexions with ventral and dorsal spinal roots (bessou & pagés, 1967, 1972) have been prepared in cat's tenuissimus muscles with the aim of cinephotographically recording intrafusal movements induced by the stimulation of single static or dynamic gamma axons; the time cours of these movements and the morphological kind of activated intrafusal muscle fibres have been established. 2. displacements of spindle guiding marks in the equ ...1975128625
[muscular spindles and their functions in the control of movement]. 1975128645
effects upon spindle discharges of electrical stimulation of static fusimotor fibers with concomitant application of muscle vibration.discharges of single afferent fibers from the primary endings of the soleus muscle spindles were recorded from thin dorsal root filaments in cats anesthetized with urethane and chloralose. the distal cut end of the ventral root was split into fine filaments to obtain functionally single fusimotor fibers. the fusimotor fibers obtained in this study were of the static type. the soleus muscle was sinusoidally stretched at 70 hz with various amplitude concurrently with 100 hz electric stimulation of ...1975128648
[the effect of "uremia toxins" on the enzymes of the active electrolyte transport]. 1975128683
feline cardiomyopathy.cardiology was diagnosed by means of clinical, radiographic, electrocardiographic phonocardiographic, angiocardiographic, and pathological findings in 271 or 3,745 cats necropsied from january 1962 to april 1974. the affected cats can be divided into three groups on the basis of the gross and microscopic pathological lesions: 1)endocarditis and myocarditis in 20 young cats; 2)endomyocardial fibrosis and left ventricular hypertrophy in 182 cats; and 3)myocardial degeneration and biventricular dil ...1975128793
studies on the metabolism of beta-hydroxy- aspartic acid.the content of beta-hydroxyaspartic acid was measured in the urine of man and several species of animals. the configuration of urinary beta-hydroxyaspartic acid was deduced to be l-erythro in form by chromatographic comparisons with authentic samples. an increased excretion of urinary beta-hydroxyaspartic acid was observed in cats when serine or thiamine was administered with glycine. glycine-1-14c administered to rats was incorporated into the urinary beta-hydroxyaspartic acid. the formation of ...1975128988
[multiunit activity of the inferior olive during a conditioned motor sequence].multinuit activity from the inferior olive was recorded in chronic cats during a learned motor task. the animals were trained to perform a succession of rapid flexion-extension arm movements alternating with two maintained postures. no significant differences were observed in the olivary activity during maintained postures. however an increase of activity occurred before the beginning of the flexion detected on the biceps emg recordings. the first modifications of olivary activity occurred in sy ...1975129208
[respiratory effects of electric stimulation of pancreatic afferents in lightly anesthetized cats].electrical stimulation of the pancreatic anterior part produces a respiratory arrest followed by a short polypnea. in some cases (20%) the same effects are obtained by electrical stimulation of the afferent nerves. the afferent fibres involved in this phenomena are situated in the great splanchnic nerves.1975129230
[hepatotropism of tyzzer bacteria in experimentally infected chick embryos].tyzzer's organism from mice propagated more remarkably in hepatocytes than in yolk-sac epithelial cells producing confluent necrosis of the liver after intravenous as well as intravitelline inoculation. some lesions with bacterial growth were also produced in the heart muscles and kidneys. the organisms from mouse, rat, hamster and kitten were shown to be equally pathogenic for chick embryos.1975129246
[a meter for instantaneous values of volume blood flow rate and frequency of cardiac contractions]. 1975129343
classification of fusimotor fibers in the primate.the classification and distinguishing characteristics of fusimotor fibres of the baboon soleus muscle have been studied by determining the effects of single fusimotor fiber stimulation on the response of isolated spindle afferents to muscle stretch. as in the cat, fusimotor fibres in the baboon were divisible into static and dynamic types on the basis of the effect of their stimulation at 200/s on the dynamic index of the primary afferent. single fusimotor fibres had the same qualitative effect- ...1976129544
the effects of muscle cooling and stretch on muscle spindle secondary endings in the cat.1. the objectives of the investigation were to identify the muscle spindle endings which respond to cooling of the relaxed muscle and to study their response to stretch. 2. the discharge of single afferents from 162 de-efferented muscle spindles in the relaxed medial gastrocnemius muscle of the anaesthetized cat was studied in vivo during cooling of the muscle from 37 to 24 degrees c. temperature measurements were made at the inner surface of the muscle, while cooling (never below 15 degrees c) ...1975129561
analysis of activity of muscle spindles of the jaw-closing muscles during normal movements in the cat.recordings have been made of afferent activity from spindles of the jaw-closing muscles, together with jaw movement and e.m.g. from temporalis and masseter in conscious, unrestrained cats. 2. in the twenty-nine units studied, the pattern of spindle behaviour observed during eating and lapping was generally what might be expected of stretch receptors. maximal firing frequencies were found during opening of the mouth (lengthening), while during active closing the discharge was progressively reduce ...1975129562
proceedings: time course of activity in intrafusal fibres in isolated cat muscle spindles. 1976129564
[experimental investigation concerning the substitution of the orbital floor of the cat (author's transl)].in 12 cats the floor of the orbit including the infraorbital margin had been totally resected on both sides. the 24 orbital defects were substituted by complete homologous floors of the orbit which had been preserved in thiomersalate, autologous bone from the tegmen of the sinus frontalis of cats, autologous and homologous cartilage and lyophilizised human dura. all implants healed well. it was found that both autologous and homologous bone implants gave the most stable mechanical connection to ...1975129617
[votings of the federal health council--meeting nov. 5 and 26, 1974]. 1975129735
spasticity: actions of selectivity activated group ii muscle spindle afferents on extensor motoneurons. 1975129880
effects on non-depolarizing neuromuscular blocking agents on peripheral autonomic mechanisms in cats.intravenous dose-response relationships were used to correlate neuromuscular paralysis with effects on autonomic mechanisms in anaesthetized cats. whereas autonomic blockade with tubocurarine occurred at parasympathetic and sympathetic ganglia, neuromuscular paralysing doses of gallamine, alcuronium, pancuronium and fazadinium caused blockade at vagal postganglionic sites in the heart. the vagolytic (atropinic) activity of these compounds in cats relative to their neuromuscular blocking activity ...1976130154
some pharmacological effects of p-chlorophenylalanine unrelated to tryptophan hydroxylase inhibition.1 experiments were performed on a variety of tissues from different species to establish whether or not the properties of p-chlorophenylalanine methyl ester (pcpa) included a 5-hydroxytryptamine (5-ht)-like action which might explain the soporific action of pcpa in chicks. 2 pcpa, like 5-ht, contracted the rat fundal preparation (as did pcpa base), and in cats enhanced twitch tension of a lower limb flexor reflex, evoked adrenal medullary secretion and attenuated histamine-induced gastric secret ...1976130179
the functional role of the muscle spindles--facts and hypotheses.a review is given of recent work on the functional role of muscle spindles in the control of movement. the fusimotor neurons (gamma motoneurons) maintain the spindles in a state of responsiveness to length and to rate of change of length of muscle. centrifugal control of muscle spindles takes two forms: first, a steady or slowly fluctuating tonic firing of fusimotor neurons, as a part of general states of arousal or readiness-to-move, independent of the firing of skeletomotor neurons (alpha moto ...1975130185
hematologic and radiographic changes in cats after inoculation with infective larvae of dirofilaria immitis.hematologic and radiographic findings in 15 domestic cats inoculated with 25, 100, or 200 to 400 infective larvae of dirofilaria immitis and in 5 uninoculated cats were compared. eosinophilia and leukocytosis developed 3 to 5 months after inoculation; packed cell volume and hemoglobin values were similar for inoculated cats and controls. changes detected in radiographs of inoculated cats were: (1) increased visualization of the pulmonary arteries; (2) right-side cardiac enlargement; and (3) diff ...1976130366
proportion of muscles spindles supplied by skeletofusimotor axons (beta-axons) in peroneus brevis muscle of the cat.of 32 cat peroneus brevis spindles, 23 (72%) were found to be supplied by a least 1 skeletofusimotor or beta-axon. a motor axon was identified as skeletofusimotor when repetitive stimulation of it elicited both the contraction of extrafusal muscle fibers and as acceleration of the discharge of primary ending, which persisted after selective block of the neuromuscular junctions of extrafusal muscle fibers. the block was obtained by stimulating single axons at 400-500/s for a few seconds. of 135 a ...1975130468
initial burst of primary endings of isolated mammalian muscle spindles.the initial burst has been studied in primary endings of isolated mammalian muscle spindles subject to controlled ramp-and-hold stretch. near the onset of ramp stretch the primary ending discharges at a frequency dependent on stretch velocity. the initial burst is reduced or abolished by repetitive stretch. after block of impulse activity by tetrodotoxin, the receptor potential of primary endings shows an initial component, a rapid depolarization which occurs near the onset of ramp stretch at th ...1976130469
the effect of l-tryptophan on spinal cord c-fiber reflexes.c-fiber reflex were recorded from an ipsilateral s1 ventral root in the acute decerebrate spinal (t10) cat after stimulation of the superficial peroneal nerve. l-tryptophan, infused in a dose of 150 mg/kg, increased the c-fiber reflex to 210% (s.e.m. +/- 30.1%) of control. this effect was antagonized by cyproheptadine, 0.5 mg/kg. l-tryptophan increased the c-fiber reflex to 176% (s.e.m. +/- 13.0%) of control after p-chlorophenylalanine pretreatment. pretreatment of the cats with the decarboxylas ...1976130482
alterations of synapses on axotomized motoneurones.1. properties of medial gastrocnemius motoneurones in cats were examined with intracellular electrodes 1-77 days after partial transection of the medial gastrocnemius muscle nerve. 2. three sequential stages of reaction were defined: (i) firstly, conduction velocity of axotomized motoneurones fell, but e.p.s.p. properties and ia-motoneurone connectivity were normal; (ii) secondly, e.p.s.p.s became characterized by prolonged rise times and half-widths and by diminished amplitudes; (iii) finally, ...1976130483
role of sarcolemmal changes in cardiac pathophysiology.sarcolemmal ca++-atpase, mg++-atpase, and (na+-k+)-atpase activities were increased in late stages of heart failure in myopathic hamsters (bio 14.6) without any changes in the adenylate cyclase activity. on the other hand, these hamsters at early and moderate stages of heart failure showed depressions in mitochondrial calcium binding and uptake and microsomal calcium binding. sarcolemmal (na+-k+)-atpase was decreased in failing hearts because of substrate lack, oxygen lack, and perfusion with ca ...1976130663
[vertical vergences. i. physiological and pathological aspects].the vertical vergences are rather weak physiological conjugate movements of the eyes. when the ocular axes approach each other or deviate, a vertical convergence or divergence occurs. these reflex movements are evoked either by visual stimuli (fusional vergence) or by labyrinthine stimuli. in pathological situations vertical vergences may become evident in permanent or alternating hyperphorias, in the strabismus occurring in the hertwig-magendie syndrome, in see-saw nystagmus and in labyrinthine ...1975130871
[ocular electrophysiology 1973]. 1975130886
[ocular electrophysiology 1973]. 1975130894
proceedings: neuromuscular and cardiovascular studies with dimethyl tubocurarine in anaesthetized cats, rhesus monkeys and man. 1976130951
[electrical activity and richness in neuromuscular spindles of the respiratory muscles of the cat]. 1975130990
localized proximal esophagitis secondary to ascorbic acid ingestion and esophageal motor disorder. 1976131047
inhibition of glucose utilization for acetylcholine synthesis by cerebrospinal fluid. 1976131180
[negative correlation between dopamine and serotonin levels in certain brain structures: neurochemical and morpholigical aspects]. 1976131181
the effect of low amplitude muscle vibration on the discharge of fusimotor neurones in the decerebrate cat.1. longitudinal vibration (50-100 mum, 100-300 hz) has been applied to the triceps surae tendon to examine its effect on the tonic discharges of gastrocnemius medialis fusimotor neurones in the decerebrated cat. 2. for nineteen out of twenty-seven fusimotor neurones vibration consistently caused a small rise in discharge frequency. the remaining eight neurones showed no respose to the vibration which always evoked a considerable discharge in alpha motoneurones. 3. the reflex excitation of fusimo ...1976131188
role of superior colliculus serotonin in the grooming behaviour of cats. 1976131256
interaction of visceral and somatic afferentation at the level of postsynaptic spinal cord elements.the interaction of visceral and somatic afferentation at the level of postsynaptic spinal cord elements was studied in cats. the effect of conditioning stimuli on the propriospinal (ps) and suprasegmental (ss) component of the tested unit responses was compared. afferentation from the splanchnic nerve completely inhibited the ss component of somatomotor motoneuronal responses; the ps component was only partly inhibited. inhibition persisted even after the conditioning stimulus-induced changes in ...1976131335
[role of ventral surface of brain stem in control of arterial pressure and in hypotensive action of clonidine].superficial destructions of the brain stem have been performed in cats at the level of the chemosensitive areas "s". these destructions produced a drop in blood pressure, which was transient in 9 and definitive in 4 animals. in 6 sham-operated animals, clonidine (15 mug/kg), injected intravenously, always induced a marked fall in blood pressure, whereas in the 10 animals which have maintained or regained normal blood pressure after the destruction of the areas s, clonidine no longer induced any ...1975131637
inhibition of extensor gamma motoneurons by anatagonistic primary and secondary spindle afferents.about 2/3 of the gamma efferents isolated from the medial gastrocnemius nerve were inhibited by longitudinal high-frequency vibration applied to the tendons of the non-contracting pretibial flexors (decerebrate cats). the inhibition appeared at 15-25 mum amplitude of vibration and increased up to maximum at nearly 100 mum. increasing the frequency of vibration from 100 to 300 hz increased the inhibition. the reflex effects elicited by muscle vibration corresponded well in incidence and magnitude ...1976131934
[epizootology of opisthorchosis]. 1976132005
identification of the mucopolysaccharides in catecholamine-containing subcellular particel fractions from various rat, cat and ox tissues.subcellular fractions containing adrenergic vesicles were obtained from bovine adrenal medulla and splenic nerve, rat and cat heart, and rat spleen. the fractions were washed free from lipids, digested with papain and the mucopolysaccharides (mpss) then precipitated from the supernatant with ethanolic potassium acetate. the mpsswere identified by several different methods--microelectrophoresis on cellulose acetate in various media, cellulose column chromatography using elution solvents of incre ...1976132083
drugs and pgo waves in the lateral geniculate body of the curarized cat. i. pgo wave activity induced by ro 43284 and by p-chlorophenylalanine (pcpa) as a basis for neuropharmacological studies.depletion, either predominantly of brain noradrenaline (na) or preferentially of brain 5-hydroxytryptamine (5-hi), was achieved in cats by a single i.p. dose of 20 mg kg(-1) of ro 4-1284, a benzoquinolizine derivative reducing the storage capacity of monoamine neurones, or by two i.p. injections of 300 mg kg(-1) of p-chlorophenylalanine (pcpa), an inhibitor of tryptophan hydroxylase. the ponto-geniculo-occipital (pgo) waves induced by these drugs (abbreviated pgo1284 and pgopcpa, respectively) w ...1976132146
[the effect of 1-adamantyl radicals on curare-like activity].in the series of polymethylene bis-ammonium salts r(ch3)2n(ch2)nn(ch3)2r . 2i--(r=ch3 or ad) a study was made of the significance of hydrophobic 1-adamantyle radicals (1--ad) for curare-like activity. administration of 1-ad radicals into the cation groups of depolarizing agents (n-9--11) altered their mechanism of action and diminished their activity. attachmeni of 1-ad radicals to the both quarternary nitrogen atoms of the antidepolarizing agents (n=5 and 6) sharply increased their curare-like ...1975132205
immune complex disease in cancer. 1975132315
[action of some bis-quaternary derivatives of fluorene and related compounds on the skeletal muscles of vertebrates].in experiments with skeletal muscles of cats, rats and frogs bis-trimethylammonium derivatives of fluorene are shown capable of being strong muscle relaxants of the depolarizing type of action and that the presence of sulfamide or ester groups in the chain between nitrogen atoms is not indispensable for their high activity.1975132359
[pharmacological characteristics of a new curariform compound from a series of naphthalene-peri-tetracarboxylic acid derivatives].experiments staged with rabbits, cats, frogs and chicken have proved tetracarboxylic acid dibenzosulphoethylate-bis (para-piperidinophenol)-diimidonaphthalene-1, 4, 5, (see article) to be capable of totally blocking the neuro-muscular conduction in a dose of 0.5 mg/kg and to block 20 per cent of it in a dose of 0.3 mg/kg. the action of the compound on the arterial pressure is half as great as that of d-tubocurarine. a pharmacological analysis conducted on the musculus rectus abdominus of the fro ...1975132362
an experimental model for the study of exercise-induced skeletal muscle hypertrophy.a procedure for training laboratory cats to perform weight-lifting exercise has been developed. this program consists of operantly conditioning adult cats to move a bar a specific distance with their right forelimb to receive a food reward. weights attached to the bar via a pully are lifted as the bar is moved. the cat is then exercised at the same load for 5 days before the weight is increased. a linear potentiometer, attached to the hinged bar, produces an analog voltage proportional to the ba ...1976132418
proceedings: inhibition of fusimotor neurones on eliciting contraction of the homonymous muscle. 1976132527
lsd acts synergistically with serotonin depletion: evidence from behavioral studies in cats.administration of lsd (100 mug/kg, ip) or the serotonin depleting drug p-chlorophenylalanine (150 mg/kg/day for 5 days) both induce dramatic behavioral changes which include the common stereotyped responses of rapid flicking movements of the limbs and abortive attempts at grooming. the combined action of lsd and p=chlorophenylalanine results in a marked increase in the occurrence of these behaviors, suggesting that lsd acts synergistically with serotonin depletion. these data therefore support t ...1976132670
changes in the pattern of breathing caused by chest vibration.vibration of 100 hz was delivered longitudinally onto the sternum of anaesthetized cats and rabbits. vibration consistently reduced the tidal volume by 10-15% without altering the end-expiratory point, and occasionally reduced the respiratory rate. vibration applied during inspiration reduced the tidal volume as much as if delivered over several breaths. expiratory vibration did not alter the course of the expiration, nor the volume of the following inspiration. the inhibition of inspiration was ...1976132689
[growth parameters of brain and its regions in the albino mouse, tupaia belangeri and spf-cat]. 1975132797
mechaism of neuromuscular blockade with some antiepileptic drugs.effects of four antiepileptic drugs, viz., diphenylhydantoin, trimethadione, phenobarbitone and ethosuximide, were studied on different in vitro and in vivo skeletal muscle preparations which consisted of frog rectus, rat phrenic nerve diaphragm and cat gastrocnemius sciatic nerve preparations. a dose related blockade of neuromuscular transmission was seen with all the compounds tested. the blockade was mainly confined to the neuromuscular junction, although direct stimulation of muscle was slig ...1976132942
myocardial necrosis, fibrosis, and dna synthesis in experimental cardiac hypertrophy induced by sudden pressure overload.the development of myocardial fibrosis as a result of cardiac hypertrophy was studied in 11 cats in which the pulmonary artery was banded, six rabbits in which the ascending aorta was banded, and eight cats with various congenital cardiac anomalies. histological examination of the myocardium revealed multifocal areas of degeneration and necrosis with healing by fibrosis in the right ventricle of cats in which the pulmonary artery was banded and in the left ventricle of rabbits in which the aorta ...1976132997
[neurotoxicity of chinoform]. 1976133072
proceedings: application of histological techniques to developing and adult cat jaw muscles. 1976133239
correlation analysis of muscle spindle responses to single motor unit contractions.1. cross-correlation techniques have been used to study the responses of muscle spindle afferents from the soleus muscle of the cat to twitch contractions of single motor units. 2. cross-correlograms (post-stimulus time histograms) were used to give the frequency of occurrence of a receptor spike at various times following the initiation of a motor unit contraction together with a display of the average twitch tension wave form. 3. the cross-correlograms revealed that the contraction of a single ...1976133241
[responses of the muscle spindles of tenotomized and hypertrophied muscles to stretch and vibration].responses of primary and secondary endings of muscle spindles were studied after tenotomy and hypertrophy in the cat soleus muscles. under constant load (100 g) background activity of primary endings in a control muscle was 17 +/- 1.5 imp/s. it did not change in hypertrophic muscle and increased after tenotomy to 26 +/- 1.5 imp/s. responses of secondary endings did not change under the same conditions. the frequency of a response from primary and secondary endings of tenotomized and hypertrophic ...1976133298
suppression of decerebrate rigidity by phenytoin and chlorpromazine.in cats decerebrated by a midcollicular section, decerebrate rigidity developed that was not alleviated by phenytoin even in doses as great as 60 mg per kilogram. chlorpromazine that depresses decerebrate rigidity in a dose-related fashion requires 1.5 to 2.0 mg per kilogram to exhibit an appreciable effect. in the presence of 20 mg per kilogram phenytoin, however, as little as 0.1 mg per kilogram chlorpromazine markedly reduces decerebrate rigidity. this drug combination did not impair neuromus ...1976133301
[study of the problem of relationship between human and animal leukemias]. 1975133467
[mitochondrial calcium metabolism in pressure-induced hypertrophy of the right ventricle]. 1975133555
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