| trypsinogen isoforms in the ferret pancreas. | the domestic ferret (mustela putorius furo) recently emerged as a novel model for human pancreatic diseases. to investigate whether the ferret would be appropriate to study hereditary pancreatitis associated with increased trypsinogen autoactivation, we purified and cloned the trypsinogen isoforms from the ferret pancreas and studied their functional properties. we found two highly expressed isoforms, anionic and cationic trypsinogen. when compared to human cationic trypsinogen (prss1), ferret a ... | 2018 | 30305676 |
| molecular investigations of the development and diseases of cerebral cortex folding using gyrencephalic mammal ferrets. | folds of the cerebral cortex (gyri and sulci) are among the most important properties of the mammalian brain. uncovering the physiological roles, developmental mechanisms and evolution of the cortical folds would greatly facilitate our understanding of the human brain and its diseases. although the anatomical features of the cortical folds have been intensively investigated, our knowledge about their molecular bases is still limited. to overcome this limitation, we recently established rapid and ... | 2018 | 30175769 |
| dermatophytic pseudomycetomas in two ferrets (mustela putorius furo). | dermatophytic pseudomycetoma is an atypical form of dermatophytosis where the infection is located in the deep dermal and subcutaneous tissues. although rare, it is most commonly associated with microsporum canis or trichophyton sp. it has been reported in cats, dogs and horses. | 2018 | 30091502 |
| marburg and ravn viruses fail to cause disease in the domestic ferret (mustela putorius furo). | the domestic ferret was recently described as a uniformly lethal model for 3 species of ebolavirus. more importantly, this new model utilizes nonadapted wild-type ebolaviruses. here, in a proof-of-concept study, we infected ferrets with different variants of the closely related marburg and ravn viruses using different doses and routes of exposure. although ferrets produced a neutralizing humoral response to challenge, we did not observe disease or viremia in any animal. the lack of disease in fe ... | 2018 | 29955887 |
| founder events, isolation, and inbreeding: intercontinental genetic structure of the domestic ferret. | domestication and breeding for human-desired morphological traits can reduce population genetic diversity via founder events and artificial selection, resulting in inbreeding depression and genetic disorders. the ferret (mustela putorius furo) was domesticated from european polecats (m. putorius), transported to multiple continents, and has been artificially selected for several traits. the ferret is now a common pet, a laboratory model organism, and feral ferrets can impact native biodiversity. ... | 2018 | 29875811 |
| pancreatitis and systemic coronavirus infection in a ferret (mustela putorius furo). | a 1-y-old spayed female ferret (mustela putorius furo) was referred for additional diagnostic evaluation after physical examination by the referring veterinarian revealed a cranial abdominal mass. the ferret had a 2-wk history of inappetence, weight loss, and lethargy. on presentation, the ferret was thin, and an approximately 3-cm mass was palpable in the cranial abdomen. no other abnormalities were noted. abdominal ultrasonography confirmed the presence of a soft-tissue structure, with a moder ... | 2018 | 29776456 |
| variability of serum aldosterone concentrations in pet ferrets (mustela putorius furo). | objective to explore sources of serum aldosterone concentration variability in a population of healthy and diseased ferrets, determine a preliminary 1 -sided reference interval for serum aldosterone concentration in healthy ferrets, and identify a decision limit to differentiate healthy from diseased ferrets on the basis of serum aldosterone concentration. design prospective threshold definition and diagnostic accuracy study. animals 78 healthy (n = 56) and diseased (22) ferrets. procedures seru ... | 2018 | 29772966 |
| validation of a radioimmunoassay of serum trypsin-like immunoreactivity in ferrets. | measurement of serum trypsin-like immunoreactivity (tli) is used to assess exocrine pancreatic function in dogs and cats. ferrets ( mustela putorius furo) serve as valuable animal models for human diseases such as cystic fibrosis and other pulmonary diseases, and may be a useful model of other diseases including pancreatitis. we developed and analytically validated a competitive radioimmunoassay (ria) for measurement of tli in ferret serum by determination of analytical sensitivity, assay linear ... | 2018 | 29717637 |
| chylous ascites associated with abdominal trauma and intestinal resection-anastomosis in a pet ferret (mustela putorius furo). | case description a 10-week-old 0.73-kg (1.6-lb) castrated male domestic ferret (mustela putorius furo) was referred for exploratory laparotomy because of pneumoperitoneum and possible septic peritonitis after being bitten by the owner's dog. clinical findings abdominal exploration revealed a large laceration of the duodenum, tears of the jejunal mesentery, and 2 small tears in the abdominal wall. chylous abdominal effusion developed 48 hours after surgery. treatment and outcome postoperative car ... | 2018 | 29701519 |
| electrochemotherapy with bleomycin of different types of cutaneous tumours in a ferret (mustela putorius furo). | mast cell tumour, sebaceous gland adenoma, and less common squamous papilloma are skin tumours in ferrets (mustela putorius furo), and early excisional surgery is usually the treatment of choice. the aim of our study was to investigate the effectiveness of electrochemotherapy (ect), a new, minimally invasive non-surgical method, as first treatment option of different types of ferret skin tumours located on surgically difficult sites. | 2018 | 29520211 |
| the influence of diet on masticatory motor patterns in musteloid carnivorans: an analysis of jaw adductor activity in ferrets (mustela putorius furo) and kinkajous (potos flavus). | broad similarities in the timing of jaw adductor activity driving jaw movements across distantly related and morphologically disparate species have led to the hypothesis that mammalian masticatory motor patterns are conserved. however, some quantitative analyses also suggest that masticatory motor patterns have evolved in concert with dietary and/or morphological specialization. here, we assess this relationship in two closely related carnivoran species with divergent diets and morphology: carni ... | 2017 | 29441707 |
| long-term increase in secondary exposure to anticoagulant rodenticides in european polecats mustela putorius in great britain. | as a result of legal protection and population recovery, european polecats (mustela putorius) in great britain are expanding into areas associated with greater usage of second-generation anticoagulant rodenticides (sgars). we analysed polecat livers collected from road casualties from 2013 to 2016 for residues of five sgars. we related variation in residues to polecat traits and potential exposure pathways, by analysing stable isotopes of carbon (δ13c) and nitrogen (δ15n) in their whiskers. 54 o ... | 2018 | 29438955 |
| non-invasive blood pressure measurement in ferrets (mustela putorius furo) using high definition oscillometry. | this study was conducted to validate the use of high definition oscillometry (hdo) for non-invasive blood pressure (nibp) measurements in ferrets and to establish reference ranges for nibp in minimally sedated, healthy, young adult ferrets (<4years of age). the bias, limits of agreement and correlation for hdo compared to direct arterial blood pressure (dabp) measurement were established in 14 anaesthetised ferrets. measurements were performed at the forelimb, hind limb and tail under hypo- (<11 ... | 2017 | 29153109 |
| extreme tetralogy of fallot with polycythemia in a ferret (mustela putorius furo). | a 5-month-old, intact male ferret (mustela putorius furo) was presented with apathy, tachypnea and exercise intolerance. on initial physical examination, tachypnea and cyanosis were the two primary clinical signs detected. the complete blood count also revealed a severe polycythemia, with lymphopenia, neutrophilia and eosinophilia. further diagnostic imaging tests were performed. the thoracic radiographs revealed cardiomegaly and a diffuse alveolar pulmonary pattern. consequently, an echocardiog ... | 2017 | 28992910 |
| morphological differentiation of the skull in two closely-related mustelid species (carnivora: mustelidae). | alexei v. abramov, andrey yu. puzachenko, and igor l. tumanov (2016) a morphological differentiation (i.e., the amount of morphological space occupied) in two polecat species, mustela putorius and m. eversmanii, has been studied. these closely related species are similar in the body size, the age of origin, and many aspects of their natural history. we have used cranial characters to estimate some parameters of morphological diversity, to compare 'morphological niche breadth' occupied by polecat ... | 2016 | 31966146 |
| a retrospective study of 17 cases of mycobacteriosis in domestic ferrets (mustela putorius furo) between 2005 and 2013. | from 2005 to 2013, 17 ferrets were diagnosed with mycobacteriosis at the authors' practices. clinical findings included ocular, respiratory, and digestive abnormalities. diagnosis was based on histopathology, specific histochemical stains, and/or on polymerase chain reaction. all bacteria identified belonged to the nontuberculous mycobacterium complex. several treatment protocols were attempted, frequently based on the use of enrofloxacin. in all, 3 ferrets were considered cured. mycobacteriosis ... | 2015 | 32288684 |
| congenital peripheral vestibular syndrome in a domestic ferret (mustela putorius furo). | a 3-month-old intact female ferret (mustela putorius furo) was presented with a 2-month history of ataxia. on physical examination, the ferret had difficulty standing upright. during the neurologic examination, the patient had a left head tilt and positional strabismus, circled to the left, and was ataxic. results of the complete blood count were consistent with a mild normocytic normochromic anemia. initial treatment was supportive. magnetic resonance imaging was performed and revealed an asymm ... | 2014 | 32362793 |
| systemic infection due to candida parapsilosis in a domestic ferret (mustela putorius furo). | an 18-month-old castrated male ferret (mustela putorius furo) was presented to the veterinary hospital for acute collapse but died despite initiation of emergency treatment. the body was submitted for a complete postmortem examination. the pathologist determined the ferret was suffering from severe necrotizing encephalitis, necrogranulomatous mediastinal lymphadenitis, and ulcerative dermatitis attributable to systemic candida parapsilosis. this is the first report of systemic candida parapsilos ... | 2014 | 32288679 |
| endogenous lipid pneumonia in a ferret (mustela putorius furo). | a 1-year-old female ferret was presented with an acute history of severe respiratory distress. abnormal clinical signs noted during the initial physical examination were hypothermia, dehydration, pale mucous membranes, tachypnea, and severe dyspnea. thoracic radiographs revealed pleural effusion, an enlarged cardiac silhouette, and areas of lung consolidation. both blood and thoracic fluid were hyperproteinemic and hypergammaglobulinemic. antibiotic, corticosteroid, and diuretic supportive treat ... | 2011 | 32288675 |
| natural sars-cov-2 infection in kept ferrets, spain. | we found severe acute respiratory syndrome coronavirus 2 rna in 6 (8.4%) of 71 ferrets in central spain and isolated and sequenced virus from 1 oral and 1 rectal swab specimen. natural infection occurs in kept ferrets when virus circulation among humans is high. however, small ferret collections probably cannot maintain virus circulation. | 2021 | 34152974 |
| host barriers to sars-cov-2 demonstrated by ferrets in a high-exposure domestic setting. | ferrets (mustela putorius furo) are mustelids of special relevance to laboratory studies of respiratory viruses and have been shown to be susceptible to severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection and onward transmission. here, we report the results of a natural experiment where 29 ferrets in one home had prolonged, direct contact and constant environmental exposure to two humans with symptomatic disease, one of whom was confirmed positive for sars-cov-2. we observed n ... | 2021 | 33858941 |
| coronaviruses associated with the superfamily musteloidea. | among the animal superfamily musteloidea, which includes those commonly known as mustelids, naturally occurring and species-specific alphacoronavirus infections have been observed in both mink (mustela vison/neovison vison) and domestic ferrets (mustela putorius furo). ferret systemic coronavirus (frscv), in particular, has been associated with a rare but fatal systemic disease. in recent months, it has become apparent that both minks and ferrets are susceptible to severe acute respiratory syndr ... | 2021 | 33468694 |
| in vitro characterisation of sars-cov-2 and susceptibility of domestic ferrets (mustela putorius furo). | severe acute respiratory syndrome coronavirus-2 (sars-cov-2) is an emerging virus that has caused significant human morbidity and mortality since its detection in late 2019. with the rapid emergence has come an unprecedented programme of vaccine development with at least 300 candidates under development. ferrets have proven to be an appropriate animal model for testing safety and efficacy of sars-cov-2 vaccines due to quantifiable virus shedding in nasal washes and oral swabs. here, we outline o ... | 2021 | 33400387 |
| sars-cov-2 seroprevalence in household domestic ferrets (mustela putorius furo). | animal infections with sars-cov-2 have been reported in different countries and several animal species have been proven to be susceptible to infection with sars-cov-2 both naturally and by experimental infection. moreover, infections under natural conditions in more than 20 mink farms have been reported where humans could have been the source of infection for minks. however, little information is available about the susceptibility of pet animals under natural conditions and currently there is no ... | 2021 | 33801548 |
| the ferret as a model for filovirus pathogenesis and countermeasure evaluation. | the domestic ferret (mustela putorius furo) has long been a popular animal model for evaluating viral pathogenesis and transmission as well as the efficacy of candidate countermeasures. without question, the ferret has been most widely implemented for modeling respiratory viruses, particularly influenza viruses; however, in recent years, it has gained attention as a novel animal model for characterizing filovirus infections. although ferrets appear resistant to infection and disease caused by ma ... | 2021 | 33951727 |
| mucosal challenge ferret models of ebola virus disease. | recent studies have shown the domestic ferret (mustela putorius furo) to be a promising small animal model for the study of ebola virus (ebov) disease and medical countermeasure evaluation. to date, most studies have focused on traditional challenge routes, predominantly intramuscular and intranasal administration. here, we present results from a non-clinical pathogenicity study examining oronasal, oral, and ocular mucosal challenge routes in ferrets. animals were challenged with 1, 10, or 100 p ... | 2021 | 33806375 |
| biodetection of a specific odor signature in mallard feces associated with infection by low pathogenic avian influenza a virus. | outbreaks of avian influenza virus (aiv) infection included the spread of highly pathogenic aiv in commercial poultry and backyard flocks in the spring of 2015. this resulted in estimated losses of more than $8.5 million from federal government expenditures, $1.6 billion from direct losses to produces arising from destroyed turkey and chicken egg production, and economy-wide indirect costs of $3.3 billion from impacts on retailers and the food service industries. additionally, these outbreaks re ... | 2021 | 34038460 |
| establishment of an induced pluripotent stem cell line from a female domestic ferret (mustela putorius furo) with an x chromosome instability. | the domestic ferret (ferret; mustela putorius furo) is an important animal model for neuroscience and preclinical/veterinary medicine owing to its highly developed cerebral cortex and susceptibility to avian influenza and corona viruses. nevertheless, there is a lack of in vitro ferret models, since immortal cell lines including induced pluripotent stem cells (ipscs) of ferrets have been scarce. in this study, we established an ipsc line from ferret skin fibroblasts. the established ipsc line, f ... | 2021 | 34088013 |