Publications

lactic dehydrogenase activity in the hair follicles of the stump-tailed macaque (macaca speciosa).		1974	4205537
testosterone-binding globulin in stump-tailed macaque monkeys (macaca speciosa).		1973	4201764
fetal hepatic drug metabolism in the nonhuman primate, macaca arctoides.		2006	4156315
structural factors influencing outflow facility and its changeability under drugs. a study in macaca arctoides.		1973	4144361
cardiovascular effects of the addition of n2o to halothane in stump-tailed macaques during spontaneous and controlled ventilation.		1974	4139153
cardiovascular effects of halothane in the stump-tailed macaque during spontaneous and controlled ventilation.		1974	4138550
assessing variation in the social behavior of stumptail macaques using thermal criteria.	this paper reports a method for comparing the environments of nonhuman primates based on biophysical, thermal criteria. the method is applied to an analysis of behaviors exhibited by group-living stumptail macaques (macaca arctoides), documented by a group-scan observation technique, to test the hypothesis that the expression of social behavior is dependent on thermal conditions. thermal conditions are identified by considering sky cover and the relative cooling power of the environment. the res ...	1985	4083338
periosteal reaction consistent with osteomyelitis in a stump-tailed macaque.		1985	4077667
immune responsiveness of monkeys exposed chronically to cigarette smoke.	eleven adult male stumptailed monkeys (macaca arctoides) were chronically exposed to either a low dose (human equivalent of 1 pack/day) or a high dose (human equivalent of 3 packs/day) of high-tar, high-nicotine university of kentucky reference cigarette smoke for 4-8 years. several parameters of their immunological response were compared to six nonsmoked control animals. the results from these experiments suggest that cigarette smoking does not significantly affect the response of spleen cells ...	1985	4017293
an animal model of myopia.	myopia develops in macaque monkeys when their lids are surgically fused at birth and kept closed for one year. this experimental refractive error has many features in common with human myopia: it is caused by progressive axial elongation of the eye, is often accompanied by fundus changes, and can only be induced before eye growth has been completed. myopia does not develop in animals raised in the dark; thus, it is triggered by an alteration of the visual input and is presumably mediated by the ...	1985	4000200
normal serum biochemical, hematological, and ekg parameters in anesthetized adult male macaca fascicularis and macaca arctoides.	selected serum enzymes, cholesterol, triglycerides, glucose, uric acid, protein, albumin, bilirubin, bun, hematology, and electrocardiograms (ekg) were obtained from adult male cynomolgus (macaca fascicularis) and adult male stumptailed (macaca arctoides) macaques. serum alkaline phosphatase, uric acid, albumin, bilirubin, mean corpuscular hemoglobin (mch), mean corpuscular volume (mcv) and monocytes were significantly lower in the cynomogus monkeys. this relationship was reversed for serum leve ...	1985	3981960
social preferences in stump-tailed macaques (macaca arctoides): effects of companionship, kinship, and rearing.	social preferences in the directionality of social behavioral patterns in a heterogeneous group of 26 stump-tailed macaques (macaca arctoides) were examined to see if kin recognition occurred. four behavioral measures were analyzed: proximity, contact, grooming, and play. three independent variables were examined: early companionship, condition of early rearing, and kinship. the latter was divided into partrilineal, matrilineal, and shared kinship. partial correlational analysis showed that soci ...	1985	3979662
aspirin or dipyridamole individually prevent lipid accumulation in primate vein bypass grafts.	although platelet inhibition with both aspirin and dipyridamole is widely prescribed for patients with coronary artery bypass grafts, data are lacking to prove that combined drug therapy has greater efficacy in preserving graft integrity than either drug given independently. thus, the ability of combined vs single drug therapy to reduce cholesterol and apolipoprotein-b accumulation were compared in autologous cephalic veins grafted into femoral arteries of 23 stump-tailed macaque monkeys. ten mo ...	1985	3969898
surgical correction of eyelid disfigurement in a stumptailed monkey (macaca arctoides).	self-aggression in an adult male stumptailed monkey (macaca arctoides) resulted in severe lower eyelid distortion, conjunctivitis and epiphora. the behavior ceased with a change in environment, but the eyelid defect, conjunctivitis and epiphora persisted, requiring corrective surgery. surgical correction was partially successful, although the animal died due to unrelated medical problems before final correction could be accomplished.	1986	3959535
malignant lymphoma in a colony of macaca arctoides.	malignant lymphoma occurred in six macaca arctoides from a colony of 83 animals during a 30-month period. the cells of two neoplasms had t cell markers. concurrent disease processes included atypical mycobacterial disease in four macaques and progressive multifocal leukoencephalopathy in one.	1985	3883635
the relative influence of arterial pressure versus intraoperative distention on lipid accumulation in primate vein bypass grafts.	atherosclerotic degeneration has been well documented to be the limiting factor for long-term function of aortacoronary vein bypass grafts. injury, including that induced by pressure distention in preparation for grafting, is thought to play a role in this degeneration. injury can be minimized by limiting the distending pressure, but vein grafts are chronically subjected to arterial pressures that far exceed native venous pressure. we evaluated the relative influence of arterial pressure and of ...	1985	3877215
immunologic abnormality in a group of macaca arctoides with high mortality due to atypical mycobacterial and other disease processes.	of 54 macaca arctoides, 44 died during the 2.5 years after their assignment to a common cage. although early deaths were due to trauma, acute gastric dilatation, and shigellosis; latter deaths were the result of a variety of uncommon diseases including atypical mycobacterial disease, malignant lymphoma, protozoan encephalomyelitis, and other necrotizing and inflammatory lesions. atypical mycobacterial disease due to mycobacterium avium intracellular serotypes was the most frequent single disease ...	1985	3873886
evaluation of pled as a chelating ligand in the preparation of gallium and indium radiopharmaceuticals.	the 68ga and 111in complexes of pled (n,n'-dipyridoxylethylenediamine-n,n'-diacetic acid) were prepared and their biodistribution determined as a function of time following i.v. injection into rats. the 68ga and 111in complexes behaved identically and were rapidly cleared from the blood via the kidneys into the urine. similar rapid urinary excretion was observed in the gamma images obtained from a stump-tailed macaque injected with 111in-pled. paper electrophoresis at ph 7.35 showed a single rad ...	1985	3869126
physiological changes during copulation in male and female stumptail macaques (macaca arctoides).	radiotelemetric recordings were made of uterine contractions in female stumptail macaques, and of heart and respiratory rate in stumptail monkeys of both sexes, before, during and after copulation. these data were fed into a multichannel recorder, along with a spoken record of behavioral changes. males' heart and respiratory rates were raised during penile thrusting, reached a peak and then fell sharply after ejaculation. uterine movements were similar during successive copulations. after uterin ...	1986	3823209
a comparison of the karyotypes of six species of the genus macaca and a species of the genus cercocebus.	karyotypes from 72-hour whole blood cultures were compared for six species of macaques (macaca arctoides, m. fascicularis, m. mulatta, m. nemestrina, m. nigra, and m. radiata) and one species of mangabey (cercocebus atys). g-bands, sequential c-bands, and late replication patterns were studied. results showed a variation in a single chromosome pair which differentiated c. atys from the macaques. heteromorphic variation in silver stained nucleolar organizing regions was seen between and within in ...	1986	3804105
castration, sex steroids, and heterosexual behavior in adult male laboratory-housed stumptailed macaques (macaca arctoides).	the sociosexual behaviors of six stable male-female pairs of stumptailed monkeys were studied in half-hour pair tests. their performance before and after castration of the males was compared. the effects of replacement therapy with sex steroids on male-female interaction were studied. also the effects of new females as sexual partners were investigated. castration caused a significant decrease in sexual behavior. individual males could display ejaculatory behavior up to about 1 year postcastrati ...	1986	3770656
the effects of clonidine on food consumption and food competition in male stumptail macaques (macaca arctoides).	the effects of clonidine on noncompetitive and competitive feeding were examined in three adult male stumptail macaques (macaca arctoides). noncompetitive feeding was examined when the subjects were individually-caged or group-caged. clonidine (1.0 mg/kg) administered im substantially increased food consumption over control values in all subjects in both housing situations. the effects of clonidine on competitive feeding behavior were evaluated in the group-caged environment. food competition wa ...	1986	3737626
congenital malformations and twinning in a breeding colony of old world monkeys.	clinical and necropsy records of malformations in old world monkeys were compiled. the numbers of malformations and birth incidence rate for each species were: rhesus macaque (macaca mulatta) 3 (1.02%); cynomolgus macaque (macaca fascicularis) 11 (1.62%); stumptail macaque (macaca arctoides) 3 (1.55%); african green monkey (cercopithecus aethiops) 4 (1.5%). there was one pair of rhesus twins (twinning rate: 0.34%). cardiovascular and central nervous system lesions accounted for 55% of all malfor ...	1987	3695398
physiological aspects of puberty in group-living stumptail monkeys (macaca arctoides).	physiological changes around the time of puberty were studied in a longitudinal manner in male and female stumptail macaques. in the male, testicular descent (mean age 3.3 years) is an early sign of puberty, which coincides with onset of the pubertal spurt in body weight and testis growth and precedes the pubertal rise in plasma testosterone. in the female no clear external signs of puberty have been found. measurements of plasma progesterone yielded proof of first ovulation (mean age 3.7 years) ...	1987	3685152
behavioral observations of sensory substitution in neonate macaques (macaca arctoides).	the ability of neonate macaque monkeys to learn to respond to artificial spatial sensory information was studied through the use of compact, head-worn, electronic spatial sonars with audible displays, which translate spatial information into auditory dimensions specifying distance, direction, and surface characteristics. three animals were born in the dark and raised without vision for 1 to 3 months while wearing either the binaural sensory aid (animal 1; kay, 1974) or the trisensor (animals 2 a ...	1987	3675854
blood variables in adult stumptail macaques (macaca arctoides) living in a captive group; annual variability.	monthly blood samples were collected for more than two years from adult stumptail macaques living in a large captive group. the social organization, feeding pattern, and food composition were stable throughout the study period. no seasonal variability was observed for any of the 30 blood variables studied. it appeared that for each variable, within-animal variance was small relative to between-animal variance. a table of means and reference ranges is presented and discussed.	1987	3625757
sexual behaviour during ovarian cycles, pregnancy and lactation in group-living stumptail macaques (macaca arctoides).	sexual interactions were studied in a large, well-integrated group of stumptail macaques, continuously living together. copulations with the highest-ranking male and with young males were equally distributed over the ovarian cycle. copulations with other adults males also occurred during all cycle phases, but were most frequent peri-ovulatory. this was most distinct in conceptive cycles. copulatory activity continued during early pregnancy, but was virtually absent during the middle and latter p ...	2013	3624423
low-dose aspirin protects against lipid accumulation in primate vein bypass grafts.	platelet inhibition with high-dose aspirin combined with dipyridamole reduces lipid accumulation and improves early patency of coronary artery bypass grafts. however, recent evidence suggests that platelet inhibition can be achieved with substantially lower aspirin doses than have been conventionally prescribed. to evaluate whether low-dose aspirin protects against lipid accumulation in bypass grafts, we studied 15 stump-tailed macaque monkeys in which autologous cephalic veins were grafted into ...	1987	3613624
hemodynamic and echocardiographic evaluation of the stumptailed macaque: a potential nonhuman primate model for pulmonary vascular disease.	stumptailed macaques (macaca arctoides) were evaluated as to their suitability as an animal model for pulmonary hypertension. animals used for this study were colony-bred. necropsy material from 63 animals revealed 32% with severe medial thickening of pulmonary arteries. twenty-nine stumptailed macaques underwent cardiac catheterization and m-mode echocardiography. hemodynamic measurement including pulmonary artery pressure response to 12% oxygen exposure identified three groups of animals with ...	1987	3612762
testosterone, testis size, seasonality, and behavior in group-living stumptail macaques (macaca arctoides).	during a 28-month period, data were collected on physiological parameters and sociosexual behavior of 13 adult male members of a large mixed-sex group of stumptail macaques living in an outdoor cage. monthly measurements of plasma testosterone, testis size, and body weight revealed no systematic seasonality. seasonal variations did occur in branch shaking and grooming (both with low rates in winter), but not in other behaviors studied (copulation, masturbation, aggression). dominance ranks were ...	2013	3610055
late effects of early binocular visual deprivation on the function of brodmann's area 7 of monkeys (macaca arctoides).	it has been shown earlier that binocular visual deprivation during the early sensitive period of life reduces the representation of visual functions in the posterior parietal association cortex of monkeys, in brodmann's area 7 (exp. brain res., 42 (1981) 1-8). moreover, the representation of somatic functions increases suggesting that competitive mechanisms between the inputs from different modalities function during the early sensitive period of life in area 7. the aim of the present study was ...	1987	3594262
comparison of treatments for psorergates mites in stumptailed macaques (macaca arctoides).		1987	3586598
mycobacterium paratuberculosis infection in a colony of stumptail macaques (macaca arctoides).	mycobacterium paratuberculosis infection was documented in a colony of stumptail macaque monkeys (macaca arctoides), with 29 (76%) of 38 monkeys infected and shedding organisms in feces. thirteen deaths have occurred during the past five years. animals without overt clinical disease were shedding as many as 2 x 10(6) colony-forming units of m. paratuberculosis/g of feces. intestinal tissues from animals dying of this disease contained up to 10(8) colony-forming units of m. paratuberculosis/g of ...	1987	3559275
action of topical minoxidil in the bald stump-tailed macaque.	the effect of topical minoxidil (5% and 2% solutions) on hair regrowth was studied in the frontal bald scalp of 18 adolescent and adult stump-tailed macaques (macaca arctoides). gross observation of the hairiness and folliculogram analysis of the skin biopsy specimens have shown that minoxidil induces the enlargement of vellus follicles to the size of middle to terminal follicles (regrowth of hair effect), minoxidil maintains the terminal follicles in the prebald scalp of periadolescent animals ...	1987	3558911
heterosexual experience and isosexual behavior in laboratory-housed male stump-tailed macaques (m. arctoides).	three feral-born male stump-tailed macaques were housed together for 9 years from prepubertal age. the animals were then transferred to another laboratory and housed individually. they were pair-tested with each other (isosexual tests) and with females (heterosexual tests) for the first time in their adult lives. the study revealed that these males preferred females as sexual partners. they preferred each other as groom partner. the heterosexual experience did not drastically alter sociosexual b ...	1986	3524510
search for cea-like molecules in polymorphonuclear leukocytes of non-human primates using monoclonal antibodies.	the monoclonal anti-cea antibody zik-a42-a/c1 which reacts with nca of human polymorphonuclear leukocytes was found to bind also to polymorphonuclear blood leukocytes of the following non-human primates tested: hamadryas baboon (papio hamadryas), stump-tailed monkey (macaca arctoides), pig-tailed monkey (macaca nemestrina), and rhesus monkey (macaca mulata). no binding was observed to mononuclear blood leukocytes. it was concluded that non-human primates contain cea-like substances in their poly ...	1986	3518651
effect of lhrh immunoneutralization on follicular development, the lh surge and luteal function in the stumptailed macaque monkey (macaca arctoides).	a dose of 100 microliter of a potent ovine lhrh gamma globulin inhibited ovulation in the cyclic rat when administered at 12:00 h on the day of pro-oestrus. a dose of 10 ml of the preparation was administered i.v. to female stumptailed macaques to achieve circulating antibody titres 3-4-fold higher than in the rat. in an ovariectomized macaque, this caused a marked fall in serum concentrations of lh to less than 10% of pretreatment values and also a significant, though less pronounced, fall in f ...	1986	3511254
studies on the vasoocclusive crisis of sickle cell disease. iii. in vitro and in vivo effect of the pyrimido-pyrimidine derivative, ra-233: studies on its mechanism of action.	red cell deformability was found to be impaired in ss- and sc-genotype and to a lesser extent sa-genotype red blood cells as compared with those of aa-genotype. ra-233 in vitro improved deformability according to a bell-shaped dose-response curve. ra-233 also prevented experimental vasoocclusive crisis in macaca arctoides. deoxygenation of ss-genotype red cells resulted in sickle shape transformation, atp depletion, potassium efflux, and attachment of hemoglobin molecules to the membrane. these ...	1987	3480932
behavioral aspects of puberty in group-living stumptail monkeys (macaca arctoides).	behavioral changes before and around the time of puberty were studied in a longitudinal manner in male and female stumptail monkeys. around the time of testicular descent (mean age: 3.3 years) males started to become more aggressive towards adult males. within two years following testicular descent males rose in rank with the support of others and reached stable (sub)top positions in the dominance hierarchy. in the female rank-stabilization took place gradually between one year before and two ye ...	1988	3406153
[the occurrence of thermophilic campylobacter spp. in primates of the species macaca mulatta and macaca arctoides in a laboratory animal facility].		1988	3401207
fetal gender and aggression in pregnant stumptail monkeys (macaca arctoides).	agonistic behaviors of pregnant female stumptail monkeys, members of a large, well-integrated group continuously living together, were studied during 480 observation hours (over 32 months). a total of 28 pregnancies of 20 females occurred, resulting in 12 male and 16 female live infants. the main finding was a significant decline in aggression, both received and performed, during the course of pregnancy. there was no clear unequivocal effect of fetal gender on aggressive behavior of the mothers- ...	1988	3371559
a scanning electron microscope study of monkey maturation-stage ameloblasts.	the maturation-stage enamel organs of macaca arctoides and macaca mulatta were examined in order to determine whether the cells were similar to those of the continuously erupting rat incisor. tooth buds of the permanent dentition were fixed in formaldehyde-glutaraldehyde and post-fixed in oso4. the enamel organs were separated from the enamel during dehydration, critical-point-dried, metal-coated, and examined in a scanning electron microscope. the results showed that there were few differences ...	1988	3183157
behavior of monkeys during opiate withdrawal and locus coeruleus stimulation.	the noradrenergic nucleus locus coeruleus (lc) has been implicated in morphine withdrawal. the behavioral effects of opiate antagonist-precipitated morphine withdrawal in chair-restrained macaca arctoides were therefore compared with lc electrical field stimulation. both continuous lc stimulation and administration of low doses of naloxone to morphine pellet implanted monkeys produced a significant increase in the same group of behaviors reported previously to follow activation of the lc, withou ...	1988	3174735
effects of an lh-releasing hormone antagonist on the secretion of lh, fsh, prolactin and ovarian steroids at different stages of the luteal phase in the stumptailed macaque (macaca arctoides).	the role of the pituitary gonadotrophins in controlling luteal function in the stumptailed macaque has been investigated by examining profiles of serum concentrations of lh, fsh, progesterone and oestradiol in daily blood samples from 13 monkeys during the menstrual cycle, and in blood samples taken at hourly intervals between 09.00 and 21.00 h on different days of the luteal phase in 13 cycles. the effects of acute withdrawal of gonadotrophins was investigated by administering a single injectio ...	1986	3097236
monkeys infected with ascaris suum (a new in vivo model of airway disease): protective effect of nedocromil sodium and sodium cromoglycate against bronchial antigen challenge.	the experimental infection of macaca arctoides monkeys with the nematode parasite ascaris suum induces an ige-mediated immediate hypersensitivity reaction similar to that seen in naturally sensitive animals. in the present study, the effects of inhalation of ascaris suum antigen on lung function in infected monkeys were investigated, together with the effects of aerosolized nedocromil sodium and sodium cromoglycate (each 4 mg) given 5 min prior to antigen challenge. ascaris suum-infected macaca ...	1986	3021491
sleep in macaca arctoides and the effects of prazosin.	polygraphic (eeg, eog, emg) 12-hr recordings were made in 3 adult monkeys (macaca arctoides) to document their normal sleep pattern and to examine the effects of prazosin, an alpha-1-adrenoceptor antagonist. in comparison to man, rem episodes appeared at shorter intervals (50 min) and they always ended in movement arousal or waking up. as in man the proportion of deep sleep decreased and the proportion of rem sleep increased towards morning. during eight hours after parenteral administration of ...	1986	3016775
cloning and characterization of budgerigar fledgling disease virus, an avian polyomavirus.	the dna of a virus isolated from fledgling budgerigars, designated bfdv, was cloned and analyzed with regard to its relationship to the polyomavirus subgroup of the papovavirus family. under relaxed conditions, the dna of bfdv cross-hybridized with the dnas of members of the polyomavirus subgroup, such as the mouse polyomavirus, the monkey viruses simian virus 40, stump-tailed macaque virus, and lymphotropic papovavirus, and the human viruses jcv and bkv. under stringent conditions, however, no ...	1986	3010557
[monkey b-lymphocyte subpopulations transformed by baboon herpes virus in vivo and in tissue cultures].	baboon herpes virus (bhv) similarly to human epstein-barr virus shows tropism to b cell subpopulation. in lymphoblastoid cultures transformed in vitro by bhv no e-rfc (t cells) are found but there are b cells with surface and cytoplasmic immunoglobulins. in a number of cultures igm could be detected only in the cell cytoplasm. e-rfc are detectable in cultures in early passages but not after 17 passages which may be due to their elimination. the time course of cell-mediated immunity values was st ...	1985	3000082
[the immune structure and specific laboratory indices of acute hepatitis a in lower monkeys of the sukhumi nursery].	the study of the rate of occurrence of hepatitis a (ha) markers among monkeys, both newly arriving and those born and living for long periods (aboriginals) in the sukhumi farm, was carried out. the rate of detection of antibody to hav (anti-hav) was shown to vary from 47% (papio hamadryas) to 100% (macaca arctoides and macaca fascicularis). the level of infection with hav varied among different groups of the same species: macaca rhesus from 30% to 96%, papio hamadryas from 0 to 82%. during a lon ...	1988	2854676
[signs of natural infection with hepatitis a in brown macaques (macaca arctoides)].	the results of examinations of stump-tailed monkeys (m. arctoides) held in captivity are presented. the presence and levels of anti-hav and anti-hav class m in the blood sera of monkeys were determined by the enzyme-immunoassay (eia), and alanine aminotransferase (aiat) activity was measured. hav in stool specimens collected from the monkeys was detected by immune electron microscopy and eia. in the first examination, 2 out of 10 monkeys were found to have anti-hav and one of them to have anti-h ...	1987	2829437
sex differences in intra-group spacing behaviour in stumptailed macaques (macaca arctoides).		1989	2807092
deprived somatosensory-motor experience in stumptailed monkey neocortex: dendritic spine density and dendritic branching of layer iiib pyramidal cells.	infant macaque monkeys (macaca arctoides) were individually raised to age 6 months in large clear cubes built into one wall of a control colony that allowed them visual access to it but not tactile contact. the two deprivation conditions (cond 2 and cond 3) were equal both in physical size and with respect to partial social isolation. they differed in the degree of somatosensory-motor opportunity available during development in that the cond 2 chamber was empty, whereas cond 3 contained ladders, ...	1989	2794116
[microbiological development studies in a clinically healthy, closed primate colony (macaca mulatta, macaca arctoides) after the establishment of a salmonella infection].	a case of a salmonella infantis septicemia in a primate (macaca mulatta) probably induced by shipment stress gave rise to microbiological examination of fecal samples from all animals of a since 1976 closed colony of macaca mulatta and macaca arctoides. during 3 investigations carried out in 3 week intervals salmonella-positive animals were separated immediately from the stock. at the first examination 3 of 52, and at the second 2 of 49 samples were found to be salmonella-positive. at the third ...	1989	2781877
scanning electron microscopy of monkey secretory- and transitional-stage enamel organ cells.	this scanning electron microscope (sem) study of secretory- and transitional-stage enamel organ cells of the permanent dentition of macaca mulatta and macaca arctoides was undertaken because the topography of these cells in primates has not been described in the literature. comparison of our results with murine enamel organ morphology reported previously revealed not only many similarities, but also some significant differences. tooth buds of the permanent dentition were routinely prepared for s ...	1989	2632602
complete primary structure of statherin, a potent inhibitor of calcium phosphate precipitation, from the saliva of the monkey, macaca arctoides.	human saliva, which is supersaturated with respect to basic calcium phosphate salts, is stabilized primarily by the presence of two classes of phosphoproteins, statherin and the acidic proline-rich proteins (prp). these molecules act by inhibiting both primary (spontaneous) precipitation of calcium phosphates in saliva and secondary (surface induced) precipitation of these salts onto dental enamel. the complete amino-acid sequences of several human prp and the n-terminal sequence of prp from sal ...	1989	2613439
[the structure and patterns of support in the encounters of the brown macaque (macaca arctoides)].	aid and cooperation in agonistic encounters have been studied in two groups of stumptail macaques keeping in the open-air cages of nature type. the basic agonistic ranks are found and the cases of aid in encounters are classified. a quantitative analysis using the coefficient reflecting the individual rank, kin and frequency of different aids is carried out. the existence of mechanisms of aggression removal within group is revealed, the role of individual ranks and kin in keeping stability in gr ...	1989	2611299
predictive structure-activity relationships in a series of pyranoquinoline derivatives. a new primate model for the identification of antiallergic activity.	a new primate model has been developed for the evaluation of antiallergic agents. compounds are tested for their ability to inhibit anti-ige induced histamine release from the bronchoalveolar mast cells lavaged from the lungs of macaca arctoides infected with the parasite ascaris suum. a number of 6-substituted pyranoquinoline derivatives have been evaluated and the activities were subjected to hansch analysis. a highly significant correlation with lipophilicity (pi) and hammett sigma p values w ...	1988	2455052
increase in retinal vasoactive intestinal polypeptide after eyelid fusion in primates.	lids were fused in six neonatal and one adult macaque monkey (macaca mulatta and macaca arctoides) and were kept fused for 1 to 18.5 months. the juvenile macaques, but not the adult one, developed myopia due to excessive elongation of the eye. in all animals, the immunohistochemical reactivity of the retina for vasoactive intestinal polypeptide (vip) was much higher in the closed than in the open eyes. the neuropeptide was localized to the perikaryon and dendrites of amacrine cells. no differenc ...	1988	2448769
characterization of primate bronchoalveolar mast cells. ii. inhibition of histamine, ltc4, and pgd2 release from primate bronchoalveolar mast cells and a comparison with rat peritoneal mast cells.	as described in the preceding companion paper, bronchoalveolar lavage (bal) of the primate macaca arctoides infected with the nematode ascaris suum yields a population of cells containing a high proportion of mast cells (21%). nedocromil sodium, a new drug undergoing clinical evaluation for the treatment of reversible obstructive airways disease, inhibited the release of histamine, ltc4, and pgd2 from these cells challenged with antigen (with ic30 values of 2.1 x 10(-6) m, 2.3 x 10(-6) m, and 1. ...	1986	2431049
characterization of primate bronchoalveolar mast cells. i. ige-dependent release of histamine, leukotrienes, and prostaglandins.	large numbers of functional mast cells were obtained by bronchoalveolar lavage (bal) of macaca arctoides monkeys that had been infected with the nematode ascaris suum. these lavage cells, of which 21% were mast cells, released histamine, ltc4, and pgd2 in a concentration-dependent fashion when challenged with ascaris antigen or antibody to human ige. however, there was no release of histamine when these cells were challenged with compound 48/80. the amount of mediator released was highly depende ...	1986	2431048
the pharmacology of nedocromil sodium.	the pathophysiology of obstructive airways disease involves, in varying degree, components of reversible bronchoconstriction, inflammation and bronchial hyperreactivity. this multifactorial aetiology is the probable reason why no single animal model exists which is predictive of therapeutic efficacy in airway diseases, including asthma. nedocromil sodium has therefore been profiled in a number of systems ranging from simple in vitro tests and in vivo models of passive anaphylaxis to complex mode ...	1986	2429854
temporomandibular joint forces measured at the condyle of macaca arctoides.	forces were measured at the articular surface of the temporomandibular joint (tmj) condyle in two stump-tail monkeys (macaca arctoides) during chewing, incisal biting, and drinking and also during aggressive behaviors. force was measured with a thin piezoelectric foil transducer, which was cemented over the anterior and superior surfaces of the condyle. wires from the upper and lower surfaces of the foil were insulated between two layers of teflon tape and run subcutaneously to a telemetry unit, ...	1990	2353676
histologic, morphometric, and biochemical evolution of vein bypass grafts in a nonhuman primate model. iii. long-term changes and their modification by platelet inhibition with aspirin and dipyridamole.	the objectives of this study were to elucidate the long-term influence on vein bypass grafts of platelet inhibition and its late discontinuation. cephalic vein grafts were interposed bilaterally in the femoral arteries of stump-tailed macaque monkeys fed a diet that sustains plasma cholesterol levels of approximately 225 mg/dl. fifteen animals were divided into three groups of five animals each. group i received no medications and served as a control group. group ii received for the full duratio ...	1990	2308360
effects of morphine on colonic myoelectric and motor activity in subhuman primates.	we investigated the effects of numerous doses of morphine on colonic myoelectric and motor activity in monkeys. in each of four monkeys (macaca arctoides), combined strain gauge transducers and bipolar electrodes were chronically implanted at four defined sites in the colon and recordings were made for 3 h in fasted, unanesthetized animals before and after intravenous administration of morphine sulfate (10-1,000 micrograms/kg). the basal fasting pattern of colonic motility was characterized by r ...	1990	2305891
histologic, morphometric, and biochemical evolution of vein bypass grafts in a nonhuman primate model. i. sequential changes within the first three months.	the objective of this study was to define the histologic and morphometric evolution that accompanies the increase in cholesterol content of vein bypass grafts in a nonhuman primate model. cephalic vein grafts were interposed bilaterally in the femoral arteries of 15 stump-tailed macaque monkeys (macaca arctoides), which were fed a diet that sustains plasma cholesterol levels of approximately 225 mg/dl. grafts were excised from five animals for analysis on each of postoperative days 3, 7, 14, 30, ...	1990	2294369
histologic, morphometric, and biochemical evolution of vein bypass grafts in a nonhuman primate model. ii. modification of early changes by platelet inhibition with aspirin and dipyridamole.	the objective of this study was to determine the early influence of platelet inhibition on the histologic, morphometric, and biochemical evolution of vein bypass grafts in a nonhuman primate model. cephalic vein grafts were interposed bilaterally in the femoral arteries of 15 stump-tailed macaque monkeys fed a diet that sustains plasma cholesterol levels of approximately 225 mg/dl. all animals received in combination aspirin, 80 mg/day, and dipyridamole, 50 mg/day. grafts were excised from five ...	1990	2294342
dose-response effects of pentoxifylline on erythrocyte filterability: clinical and animal model studies.	ten patients with chronic occlusive arteriosclerosis received single oral doses of 100, 200, 400, 800, and 1200 mg pentoxifylline in a single-blind, placebo-controlled study. blood samples were drawn at baseline and at 2 hour intervals for 6 hours. drug and metabolite levels, as well as red cell filterability (deformability), were determined on all blood samples. statistically significant dose-response increases of red cell filterability were found 4 and 6 hours after oral medication with the do ...	1990	2196145
[analysis of b-lymphotropic oncogenic herpesvirus of macaca arctoides].	some physico-chemical and molecular-biological parameters of b-lymphotropic herpes virus of macaca arctoides (hvma) have been analyzed. the buoyant density of virions and nucleocapsids in a gradient of the percoll density is 1.10 and 1.14 g/ml, respectively, while that of dna in cscl gradient is 1.717 g/ml, which is typical for herpes viruses of primates. at the same time the homology of dna hvma with dna ebv and dna hvp is 30-45%. differences in restrictions sites between dna hvma, dna hvp and ...	1990	2175699
the complete nucleotide sequence of bovine polyomavirus.	the complete sequence of the genome of bovine polyomavirus (bpyv), formerly known as the ck isolate of the stump-tailed macaque virus, is presented. the genomic organization of bpyv is similar to that of the non-rodent polyomaviruses. with a genome size of 4697 bp, bpyv has the smallest polyomavirus genome known so far. when compared to simian virus 40 (sv40), the shortness of the bpyv genome is due mainly to differences in the coding capacity of the bpyv early region. the first exon of the prop ...	1990	2167926
the effects of depo-medroxyprogesterone acetate (dmpa) on copulation-related and agonistic behaviors in an island colony of stumptail macaques (macaca arctoides).	this study examined the effects on copulation-related and agonistic behaviors of repeated dmpa (depo-provera) treatment of adult females in a heterosexual island colony of stumptail macaques (macaca arctoides). comparison of mean rates revealed a decrease in male approach to females and dominant male following of females after they were treated with dmpa. as treatment did not affect female genital present, female approach or follow of males, we conclude, consistent with earlier results, that dmp ...	1990	2141692
inhibin secretion after treatment with an lhrh agonist and subsequent ovarian hyperstimulation induced by fsh in the macaque (macaca arctoides).	the effect of ovarian hyperstimulation with 'pure' fsh on serum concentrations of immunoreactive inhibin in macaques in which endogenous gonadotrophin secretion and ovarian activity had been suppressed by an lhrh agonist implant was studied. four stump-tailed macaques were treated with an lhrh agonist implant in the early follicular phase of the cycle. after a transient stimulatory phase oestradiol secretion was markedly suppressed, and the rises in progesterone and inhibin observed after ovulat ...	1990	2119427
neural control of eye growth and experimental myopia in primates.	macaque monkeys become myopic when raised with fused lids to expose the retina to formless shadows during the period of postnatal eye development. the effect of the abnormal visual input is an excessive expansion of the posterior segment of the eye, a process that seems to be controlled by the nervous system. the mechanism by which the nervous system influences eye growth appears to be different in the stumptailed macaque (macaca arctoides) and the rhesus macaque (m. mulatta). lid-fused arctoide ...	1990	2088678
effects of dominance rank on d-amphetamine-induced increases in aggression.	previous research has suggested that certain social factors, e.g., dominance rank, can determine the behavioral effects of drugs in individual members of a social group. in the present experiment, the effects of d-amphetamine were studied in two adult male monkeys with dominance rankings that changed during a reorganization of the social hierarchy in a captive group of stumptail macaques (macaca arctoides). a range of doses of d-amphetamine was administered to each subject, and dose-effect curve ...	1990	2087491
the effects of topical diazoxide on hair follicular growth and physiology of the stumptailed macaque.	diazoxide, an anti-hypertensive agent, has diverse pharmacologic effects; hypertrichosis, hyperglycemia associated with suppression of insulin release, and elevation of serum levels of androgens. taking advantage of the hypertrichotic side effects of diazoxide, we examined the effect of topical application of the drug on hair regrowth in the bald frontal scalp of stumptailed macaques (macaca arctoides); we also monitored systemic side effects. using 7 adult stumptails, we applied diazoxide (5% s ...	1990	2085505
[therapy of salmonellosis in macaca arctoides].	four clinically normal m. arctoides shed salmonella infantis after the stress of transportation. one animal developed diarrhea and died. after therapy with 30 mg chloramphenicol/kg bw orally for two times eight days, thereafter 10 mg neomycin/kg bw orally for eight days and finally 2 mg gentamicin/kg bw i. m., they still shed s. infantis. oral application of daily 100 mg ofloxacin (tarivid) for 10 days and repetition of that same therapy for seven days after one week without therapy terminated s ...	1990	2080512
comparative vaginal spermicidal studies in the stumptailed macaque with alkyloxynol-741, nonoxynol-9 and chlorhexidine.	alkyloxynol-741 ("agent 741") is used in the people's republic of china as a substitute for nonoxynol-9 in vaginal contraceptive formulations. however, no studies are available that compare the effectiveness of these agents as vaginal spermicides. for this reason, dissolvable polyvinylalcohol (pva) films were prepared containing various concentrations of alkyloxynol-741 and nonoxynol-9. films were also prepared containing chlorhexidine, a potentially new vaginal contraceptive agent. postcoital v ...	1990	1964633
[comparative analysis of genomes of oncogenic b-lymphotropic herpesviruses reproducing in cell lines obtained from different monkey species].	the aim of this work was to study genomes of b-lymphotropic oncogenic herpesviruses of macaca arctoides (hvma), papio hamadryas (hvp) and cercopithecus aethiops (hvgm). blot-hybridization detected inter- and intraspecific genome heterogeneity of investigated viruses in restriction sites ecor1, pst1 and hind111. virus-specific sequences in two-cell lines obtained from hvma-induced rabbit tumours can prove hvma a role in malignant tumour induction in rabbits.	1990	1964615
x-ray induced translocations in premeiotic germ cells of monkeys.	the induction of reciprocal translocations by various x-ray exposures was studied in spermatogonial stem cells of rhesus monkeys (macaca mulatta) and stump-tailed macaques (macaca arctoides) by means of spermatocyte analysis many cell generations after irradiation. the yields of translocations recovered from irradiated stump-tailed macaques were lower than those observed in rhesus monkeys and represent in fact the lowest induction rates per gy ever recorded for experimental mammals. in the rhesu ...	1991	1944375
a highly divergent simian immunodeficiency virus (sivstm) recovered from stored stump-tailed macaque tissues.	we report here the results of molecular analysis of a simian immunodeficiency virus (designated sivstm) which was isolated from a rhesus monkey inoculated with stored lymph node tissue of an asian stump-tailed macaque. the latter monkey had died in 1977 during an epidemic of acquired immunodeficiency and lymphoma at the california regional primate research center (l. j. lowenstine, n. w. lerche, p. a. marx, m. b. gardner, and n. c. pedersen, p. 174-176, in m. girard and l. valette, ed., retrovir ...	1991	1942258
synergistic effects of kinship, sex and rank in the behavioural interactions of captive stump-tailed macaques.	in almost all non-human primate species kinship, sex and rank bias the patterning of interactions among subjects, seemingly in a way that favours the individual's fitness. a number of studies have been done in order to study separately the effects of these variables, concluding that an adequate model of interactions cannot be developed assuming preponderance of a single variable. the 'willingness' of one animal to interact with another can be explained as the result of assessing the possible out ...	1991	1937281
presence of adult or juvenile relatives increases livebirth chances in captive stumptail macaques (macaca arctoides).		1991	1895335
atherogenic effect of barotrauma on in situ saphenous veins in monkeys.	the objectives of this study were to determine whether veins subjected to barotrauma in situ undergo lipid uptake and morphologic changes to the same extent as veins grafted into the arterial circulation. saphenous veins in seven stump-tailed macaque monkeys were exposed bilaterally and were circumferentially dissected free from surrounding tissue only at isolated sites. segments of the veins were distended for 1 minute at hydrostatic pressures of 125 or 350 mm hg. an undistended segment served ...	1991	1881183
multivariate comparison of the forelimb between stump-tailed and rhesus macaques.	rhesus macaques and stump-tailed macaques are sympatric in western yunnan (china), coexisting or occupying habitats that show little difference. this paper tests hypotheses based on theoretical expectation from the differing biomechanical demands of terrestrial and arboreal quadrupedalism in stump-tailed macaques and rhesus macaques, respectively. individuals of these two macaque taxa were markedly separated by the first two principal components and discriminant analyses based on 18 variables of ...	1991	1794770
effect of perivascular sympathectomy on distal adrenergic innervation in the hands of monkeys.	perivascular sympathectomy has been thought to cause distal adrenergic denervation. we performed perivascular sympathectomy for a distance of 1 cm. on two common digital arteries in the right hands of two anaesthetised macaca arctoides monkeys. four days later, samples were taken for glyoxylic acid-induced fluorescence examination of the operated and opposite control hand. the distal adrenergic nerves were morphologically normal in appearance after the perivascular sympathectomy. the operation s ...	1991	1779148
siv from stump-tailed macaques: molecular characterization of a highly transmissible primate lentivirus.	over the past 6 years, simian immunodeficiency viruses (sivs) have been isolated from four distinct species of macaques (macaca mulatta, m. fascicularis, m. nemestrina, and m. arctoides) in captivity in the united states. however, the epidemiologic and genetic relationships among sivs from the four species are not well understood. siv from stump-tailed macaques (m. arctoides) (sivstm) is unusual in that it has been associated with outbreaks of infection characterized by aggressive spread within ...	1992	1733112
studies on tumor induced angiogenesis.	methods were developed to test the angiogenic response to human tumor implants and various biologic agents in the cornea of rabbits and non-human primates (macaca arctoides). human malignant melanoma tissue and crude platelet derived growth factor (pdgf) preparations had significant angiogenic effects. purified, recombinant pdgf preparations were also effective initiators. hemorheologic agents which also inhibit platelet aggregation [e.g. pentoxifylline (px) (trental) (also found to release pgi2 ...	1991	1725679
siv of stump-tailed macaque (sivstm) is a divergent asian isolate.	analysis of molecularly cloned dnas of sivs isolated from asian rhesus macaque (macaca mulatta; sivmac) and pig-tailed macaque (macaca nemestrina; sivmne) has indicated a high degree of sequence homology between these viruses. thus sivmac and sivmne might have originated from the same or very closely related viruses. we have cloned and sequenced a pcr-amplified segment containing the ltr sequences of siv originating from a stump-tailed macaque (macaca arctoides; sivstm). comparative sequence ana ...	1991	1719204
characterization of monoclonal antibodies that distinguish simian immunodeficiency virus isolates from each other and from human immunodeficiency virus types 1 and 2.	two monoclonal antibodies (mabs) against p27 and one against p17 of simian immunodeficiency virus (siv) from rhesus macaques were produced and characterized by reacting with disrupted, viral antigens on immunoblots. human immunodeficiency virus type 1 (hiv-1), hiv-2 and siv isolates from sooty mangabey, stump-tailed macaque, rhesus macaque and african green monkey (sivsm, sivstm, sivmac and sivagm) were used for comparative analysis. the p27 monoclonal antibodies he3 and fa2 reacted with sivmac ...	1990	1689369
nicotine metabolism in stumptailed macaques, macaca arctoides.	stumptailed macaques received a single i.v. dose of 14c-nicotine (5 microci and 300 micrograms/kg) on several separate occasions to establish baselines. then they were pretreated with phenobarbital (2.0 mg/kg/day im for 7 days) and 8 weeks later pretreated with cimetidine (8.5 mg/kg/day im for 4 days). nicotine in the same dose as before was readministered after each pretreatment. the baseline pattern of nicotine metabolism observed in plasma and urine, highly reproducible within and between mac ...	2015	1686241
immunoneutralization and immunocytochemical localization of inhibin alpha subunit during the mid-luteal phase in the stump-tailed macaque.	the putative endocrine role of inhibin in the control of fsh secretion during the luteal phase in the primate was investigated by immunoneutralization. antisera against the 1-23 amino acid sequence of the n-terminus of the human inhibin alpha subunit were raised in a ewe and three macaques. antisera (10-20 ml) were administered to macaques on day 8/9 of the luteal phase and serum samples collected during the treatment cycle and post-treatment cycle for determination of fsh, oestradiol and proges ...	1992	1613435
alterations of natural hand movements after interruption of fasciculus cuneatus in the macaque.	as part of a series of investigations on the control of fine finger movements in the macaque, spontaneous use of the hand in grooming, scratching, and manipulation was observed before and after interruption of fasciculus cuneatus (fc). videotaped observations were made of four stumptail macaques (macaca arctoides) living outdoors in social groups. the monkeys were followed for 1 to 3 years postoperatively. for the first 2 weeks following surgery, all monkeys neglected the affected hand and did n ...	1992	1595323
altered precision grasping in stumptail macaques after fasciculus cuneatus lesions.	patterns of precision grasp are described in stumptail macaques (macaca arctoides) before and after lesions of the fasciculus cuneatus (fc). three monkeys were videotaped while reaching for and grasping small food items. from these videotapes, records were made of the style and outcome of each grasp. kinematic measurements were also made to describe grip formation and terminal grasp. during grip formation, grip aperture was measured as the distance between the tips of the index finger and the th ...	1992	1595322
pharmacokinetics of the organic nitrates trans-2-amino-2-methyl-n-(4- nitroxycyclohexylmethyl)-propionamide in dogs, and of 4-(2-nitroxyethyl)-piperidine in dogs and in monkeys.	the plasma concentrations of the organic nitrates (nitric acid esters) trans-2-amino-2-methyl-n-(4-nitroxycyclohexylmethyl)-propionamide (bm 12.1200) and of 4-(2-nitroxyethyl)-piperidine (bm 12.1173, cas 129999-77-5) were determined in dog plasma by capillary gas chromatography with electron capture detection (gc-ecd). intra- and interassay variation coefficients of the gas chromatographic analysis lay between 2.9 and 8.8%; recoveries amounted to 50-62%. both nitric acid esters were absorbed qui ...	1992	1472139
shared antigenic epitopes of the major core proteins of human and simian immunodeficiency virus isolates.	antigenic epitopes on the major core (gag) protein of isolates of simian and human immunodeficiency virus (siv and hiv) were compared using a panel of eleven mouse monoclonal antibodies (mabs) that recognized nine distinct gag epitopes. viral isolates used for comparison were hiv-1iiib, hiv-2rod, and siv isolates from macaque (sivmac), sooty mangabey (sivsm-ucd), african green monkey (sivagm), and stump-tailed macaque (sivstm-ucd). the relatedness of the various hiv and siv isolates, as determin ...	1992	1383547
studies on tumor induced angiogenesis.	methods were developed to test angiogenic response to human tumor implants and various biologic agents in the cornea of rabbits and non-human primates (macaca arctoides). crude pdgf preparations were found to have significant angiogenic effect. purified, recombinant pdgf preparations were also effective inhibitors (e.g. pentoxifylline (px) (which also were found to release pgi2 and t-pa) inhibited human tumor implant induced angiogenesis and reduced spontaneous metastases in 3 transplantable mur ...	1992	1377568
increased sexual behavior in male macaca arctoides monkeys produced by atipamezole, a selective alpha 2-adrenoceptor antagonist.	the effect of a highly selective and potent alpha 2-adrenoceptor antagonist, atipamezole, on sexual behavior was studied in three stumptail macaques (macaca arctoides). following im administration of atipamezole or saline control, the behavior of the male monkey with a female monkey was observed for 30 min. atipamezole dose dependently (0.01-0.15 or 0.30 mg/kg) produced a significant increase in the number of ejaculations in all three monkeys, including an old one with decreased sexual activity ...	1992	1356274
serological survey of a captive macaque colony in china for antibodies to simian type d retroviruses.	sera from 510 macaques consisting of macaca mulatta, macaca assamensis, macaca fascicularis, macaca nemestrina, and macaca arctoides were investigated for antibodies to simian aids type d retrovirus (srv) by elisa and western blot with viral antigens purified from supernatants of srv-1 infected cell cultures. of these monkeys, 104 were seropositive by elisa; only 23 were confirmed by western blot. the true positive reaction to srv was found in 15 of 463 (3.2%) m. mulatta and eight of eleven (72. ...	1992	1339171
evidence for a lentiviral etiology in an epizootic of immune deficiency and lymphoma in stump-tailed macaques (macaca arctoides).	a retrospective study determined that an epizootic of immune suppression and lymphoma in stump-tailed macaques (macaca arctoides) that began in 1976 was associated with a horizontally spread lentivirus infection. this conclusion was based on serology, epidemiology, pathology, and virus isolation. the lesions found in the stump-tailed macaques were more compatible with lesions seen in siv-infected rhesus than those seen in rhesus macaques infected with type d retroviruses. a lentivirus, isolated ...	1992	1318381
effects of periodic removal and reintroduction on the social and sexual behavior of stumptail macaques (macaca arctoides).		2005	1307077
alkylmercurial encephalopathy in the monkey (saimiri sciureus and macaca arctoides): a histopathologic and autoradiographic study.	histopathologic and autoradiographic studies were performed on monkeys of the genera saimiri and macaca after acute and chronic oral exposure to several dosage regimens of methylmercuric chloride (mehg). neuropathologic changes were primarily cortical, although subcortical lesions also were observed. autoradiographic localization of 203-hg was greatest within glial cells (particularly nissl-pump astrocytes, subependymal glia and bergmann's glia) and mast cells. high levels of label within normal ...	1975	1170707