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the effects of finasteride (proscar) on hair growth, hair cycle stage, and serum testosterone and dihydrotestosterone in adult male and female stumptail macaques (macaca arctoides).finasteride, a 5 alpha-reductase inhibitor, was administered orally (1 mg/kg.day) for 6 months to six male and five female stumptail macaques. vehicle was given to five male and five female animals over the same period of time. hair weights in a defined 1-in.2 area of frontal scalp were measured periodically every 1-2 months, and serum was collected for measurement of testosterone and dihydrotestosterone. in addition, scalp biopsies were taken before and 6 months after treatment to evaluate the ...19947962310
an animal model of visual loss from orbital hemorrhage.intraorbital hemorrhage may arise spontaneously or following orbital or periorbital surgery or trauma and may be associated with visual loss or impairment. this project was designed to evaluate the ophthalmic effects and underlying mechanism(s) associated with visual impairment secondary to intraorbital hemorrhage. an experimental surgical procedure was developed to simulate intraorbital hemorrhage. a reversible state of unilateral visual loss secondary to acutely increased intraorbital volume w ...19947947449
posterior neocortical systems subserving awareness and neglect. neglect associated with superior temporal sulcus but not area 7 lesions.in humans and monkeys, the intraparietal sulcus separates the superior parietal lobule from the inferior parietal lobule (ipl). whereas in humans brodmann's area 7 is above this sulcus, in monkeys it is below and therefore part of the ipl. in humans, the ipl consists of brodmann's areas 39 and 40. some investigators contend that the monkey homologue of the human ipl (areas 39 and 40) is the monkey's ipl (area 7). others contend that it is, at least in part, in the monkey's superior temporal sulc ...19947944999
[the cytogenetic characteristics of b-lymphoid lines from papio hamadryas baboons and macaca arctoides brown macaques].a cytogenetic analysis of 9 permanent suspension cell lines was performed. cell lines were obtained from papio hamadryas and macaca arctoides cells by different methods. five cell lines originated from non-malignant parental cells. lines spg-5 and spg-6 were analysed at early stages of cultivation, with normal karyotypes being identified. in cell lines pl-11, mal-1 and mal-4 pathological clones with structural and numerical chromosomal rearrangements appeared only following a long-term cultivati ...19947900211
malignant lymphomas induced by an epstein-barr virus-related herpesvirus from macaca arctoides--a rabbit model.animal models for epstein-barr virus (ebv) are restricted to some species of new-world monkeys which develop malignant lymphoid tumours or benign lymphoproliferative diseases after virus inoculation. similar pathological features were induced in rabbits by the ebv-related herpesvirus of macaca arctoides (hvma). in this study 17 of 32 rabbits infected with varying amounts of hvma produced from mal-1 cells developed lymphoproliferative disorders. in 13 rabbits high-grade malignant lymphomas were d ...19957503696
effect of cocaine on sexual behaviour in male stumptail macaques (macaca arctoides).the effect of cocaine (0.01-1.0 mg/kg) on sexual behaviour was studied in four male stumptail macaques (macaca arctoides). following drug-saline control administration, the behaviour of the male monkey with a female was observed for 30 min in two different behavioural conditions; in one of the conditions the baseline sexual activity was low, and in the other it was high (partial or complete separation of the male and the female between the sessions, respectively). the reversal of the cocaine-ind ...19957501667
protein-losing enteropathy in six macaques.using intravenous administration of radioactive labeled chromic chloride, which binds to plasma proteins, protein-losing enteropathy was documented in 6 macaques (macaca mulatta and macaca arctoides) with progressive weight loss and hypoalbuminemia. four clinically normal macaques lost 0.5% +/- 0.1% of the label in feces over 4 days, compared with the diseased macaques, which lost from 1.0%--14.2% of the dose during the same period. lesions in the small intestine (lymphangiectasia, amyloidosis o ...19807451327
characteristics of the menstrual cycle in nonhuman primates. iii. timed mating in macaca arctoides.analysis of five years of reproductive data from macaca arctoides showed the mean menstrual cycle length was 29.9 +/- 4.4 days. using timed mating, a conception rate of 16.3% was observed. the highest conception rate occurred after matings on day 11 of the cycle. eight pregnancies went to term and the mean gestation length was 172.4 days. the sex ratio was 137.8 males per 100 females in fetuses obtained on day 100 post-conception.19807420409
behavioral and physiological evidence of sexual climax in the female stump-tailed macaque (macaca arctoides).intense tonic/clonic uterine contractions and sudden increases in heart rate coincided with the behavioral homolog of a male ejaculatory response (minus seminal emission) in a normal female stump-tailed macaque engaged in homosexual mounting episodes. the behavioral patterns were also observed in four of ten females during 5 to 40 percent of heterosexual copulations. these observations demonstrate the existence of an orgasmic response in a nonhuman primate.19807384791
annual plasma testosterone cycle and ejaculatory ability in the laboratory-housed crab-eating macaque (macaca fascicularis).six fertile and healthy adult macaca fascicularis males were studied. radioimmunological assay of the plasma testosterone, sampled without anesthesia in the afternoon at the beginning of each month, showed an annual hormone cycle with a maximum (16.7 +/- 1.1 ng/ml) in the fall and a minimum (9.5 +/- 0.9 ng/ml) in the spring (fig. 1). using the ratio: number of ejaculations/number of trials, the ejaculatory ability of these animals (fig. 2) was estimated for 10 min in the presence of females betw ...19817349524
characterization of a simian foamy virus isolated from a spontaneous primate lymphoma.examination of tissues from a stump-tailed monkey (macaca arctoides) with a spontaneous lymphoid malignancy by light and electron microscopy confirmed the presence of a diffuse lymphoma of intermediate cell type. membranes showed positivity with anti-ia-like antisera and negativity with all other markers. in vitro cocultivation of affected tissues resulted in the isolation of an agent found to have properties idenitical to those described for simian foamy virus type 1. there was no evidence for ...19817345142
early detection of pregnancy in rhesus and stump-tailed macaques (macaca mulatta and macaca arctoides). evaluation of two radioimmunoassays and a hemagglutination inhibition test.chorionic gonadotropin (mcg) in serum and urine of monkeys was determined by a radioimmunoassay and hemagglutination inhibition (hai subhuman primate tube test for pregnancy). hai-positive pregnancy tests coincided fully with the mcg excretion patterns as determined by ria (olh beta system). the least reliable system was the hcg-beta ria. the hai test allowed accurate prediction of the parturition date.19817343666
cervical mucus penetration test for in vitro assay of vaginal contraceptive agents.an in vitro penetration test employing bovine cervical mucosa to evaluate vaginal contraceptives is presented. its usefulness for the evaluation of the potency of a formulation in preventing sperm penetration was assessed by comparison of five commercially available preparations, with the use of both human and primate spermatozoa. the results were compared with those obtained with a spermicidal test (sander-cramer method) and in vivo with the use of the primate macaca arctoides. analysis of the ...19817286275
psorergatic mange (acari:psorergatidae) of the stumptail macaque (macaca arctoides).psorergates (psorobia) sp were recovered from dermal cysts on the face, chest, and abdomen of three stumptail macaques (macaca arctoides) in a breeding colony of research animals. the lesions were multiple and appeared as white, crusted structures measuring 2 to 10 mm in diameter. these lesions were not associated with pruritus or other clinical symptoms. the mites were embedded in the epidermis and associated with mild hyperkeratosis. a few mononuclear leukocytes were present in the dermal and ...19817253556
postcoital, vaginal, spermicidal potency of formulations: the macaca arctoides (stumptailed macaque) as animal model.the macaca arctoides (stumptailed macaque) was found to be a good animal model for determining the postcoital spermicidal activity of vaginal preparations. the stumptailed macaque is easy to handle, so formulations can be inserted correctly into the vagina just before coitus. the male mates rapidly, and the entire test can be completed within 5 to 10 minutes, minimizing all extraneous factors other than those inherent to the reproductive tract and the coital act. data from postcoital breeding ex ...19817250395
primary structure of the active tryptic fragments of human and monkey salivary anionic proline-rich proteins.the primary structures of the four human salivary anionic proline-rich proteins and an analogous protein from the saliva of a monkey (macaca arctoides) have been further investigated. these proteins possess the unusual property of inhibiting crystal growth of calcium phosphate salts, and it has been proposed that they play an important role in the mouth, by preventing precipitation of calcium phosphate salts from the supersaturated saliva. the tryptic fragments responsible for this activity have ...19817228490
establishment of a breeding colony of stumptailed monkeys (macaca arctoides). 19817197315
determinants of sexual behavior of macaca arctoides in a laboratory colony.copulatory behavior of wild-born individually caged laboratory stumptail monkeys (macaca arctoides) was investigated. the monkeys were paired daily for 20 min, and altogether 536 pairings were observed. the influence of the female's menstrual cycle and social factors of male sexual activity was determined. the reactions of the other monkeys during a pairing, and masturbation behavior of the males were observed and described. it was found that when a male and female were paired daily their sexual ...19817195697
activity patterns in a stumptail macaque group (macaca arctoides).activity profiles from a group of stumptail monkeys differed significantly from the profiles previously reported for pigtail monkeys, mangabeys and geladas scored under nearly identical conditions. variables such as sex, weather and time of day, however, often had similar influences on the activity profiles of several or all of the groups. data obtained on the stumptail monkeys in this study were more similar to data collected on other groups of stumptails, living under very different conditions ...19807191389
sociopharmacology of d-amphetamine in macaca arctoides.this study was designed to assess the effects of acute d-amphetamine pretreatment on the social behavior of a heterosexual group of adult m. arctoides. the dominance status had been previously determined by use of daily group food competition tests. prior to some sessions amphetamine was administered to a single group member; whereas on other occasions all subjects were drug treated. the effects of both the individual and concurrent pretreatments were compared to those produced by saline. furthe ...19807191115
comparative cytogenetic studies in macaca arctoides with other species of macaca and man.chromosome studies of 5 males and 5 females of the species macaca arctoides from thailand were performed and the g, c and nor banding patterns obtained for comparison with other species of the genus macaca and with the human karyotype. the cytogenetic analysis showed a complement of 42 chromosomes. of the 20 autosomal pairs, 15 are submetacentric and 5 almost metacentric. pair number 9 presents a large secondary constriction, which corresponds to the only nucleolar organizer region of the whole ...19827187236
carnitine metabolism in macaca arctoides: the effects of dietary change and fasting on serum triglycerides, unesterified carnitine, esterified (acyl) carnitine, and beta-hydroxybutyrate.serum triglycerides and serum total, esterified, and free (unesterified) carnitine were measured in 21 male macaca arctoides that were switched from a low fat (5.2% w/w), high carbohydrate diet to a high fat (15.9% w/w), low carbohydrate diet for 90 days and then returned to the original low fat diet for a subsequent 76-day period. serum triglycerides and total carnitine levels fell significantly (p less than 0.05) during the initial 2 wk of feeding the high fat diet and the ratio of esterified/ ...19827091021
hydroxylation of hexobarbital and benzo[a]pyrene by hepatic microsomes isolated from the fetal stumptailed monkey (macaca arctoides). a developmental study. 19827082369
monoamine distribution in primate brain-iv. indoleamine-containing perikarya in the brain stem of macaca arctoides.the histochemical fluorescence technique for the demonstration of monoamines in the central nervous system was employed to assess the distribution of serotonin-containing neurons within the brain stem of the immature and adult stump-tailed macaque (macaca arctoides). microspectrofluorometric analysis was performed in order to verify the existence of serotonin within perikarya which contained yellow histofluorescence. serotonin-containing perikarya were found with raphe nuclei including nucleus r ...19827078733
vaginal spermicidal activity of gossypol in the macaca arctoides. 19827060775
eye movements of monkeys during discrimination learning: role of visual scanning.four experiments were conducted on stumptailed monkeys (macaca arctoides) to determine whether the high levels of visual scanning (shifts in fixation from one discriminative stimulus to the other) seen during discrimination learning play a necessary role in this learning. in experiments 1 and 2, the monkeys were given a series of two-choice, dot-pattern discrimination reversal problems. normal visual scanning before a choice response was allowed during all but the reversal trials of half of the ...19827057143
reinnervation of hair follicle end organs and meissner corpuscles in skin grafts of macaques.plugs of occipital hairy scalp and pieces of digital pads were transplanted to the frontal scalp of stump-tailed macaques (macaca arctoides). both types of grafts grew well and retained their original appearance for several years. we traced the regrowth and reinnervation of hair follicles and meissner corpuscles in sequential biopsy specimens of these grafts. two weeks after transplantation, hair follicles in the grafts appeared to have lost all integrity but began to regrow after 4 weeks. the n ...19827035577
prevention of lipid accumulation in experimental vein bypass grafts by antiplatelet therapy.the ameliorative effect of antiplatelet therapy on atherogenesis of vein grafts was assessed in autologous cephalic veins grafted into femoral arteries of 16 normolipemic and 11 hyperlipemic stump-tailed macaque monkeys. before grafting, one half of each vein was distended at high pressure (700 mm hg) and the other half at low pressure (350 mm hg). eight normolipemic monkeys were treated with aspirin, 80 mg/day, and dipyridamole, 50 mg/day, and eight were controls. when grafts were harvested at ...19826980060
characterization of a pentasaccharide in salivary mucin from the stumptail monkey, macaca arctoides.oligosaccharides were prepared by alkaline cleavage and sodium borotritide reduction. following gel filtration on sephadex g-25, [3h]-oligosaccharides were further fractionated by anion-exchange and preparative paper chromatography. the principal neutral oligosaccharide contained galnacol: glcnac: gal: fuc (1:1:2:1). using a combination of exoglycosidase digestion, periodate oxidation and methylation analysis by gas chromatography-mass spectrometry, it structure was determined to be: gal beta 1 ...19826953947
failure of chronic cigarette smoke exposure to alter plasma lipoproteins of stumptailed macaques (macaca arctoides).twenty-one 8-14 kg adult male stumptailed macaques, macaca arctoides, were fed a standard laboratory diet and divided into 3 groups. the high-dose group and low-dose group were exposed to cigarette smoke at the human equivalent of 3 packs and 1 pack per day, respectively, 7 days per week, for 3-5 years. eight animals served as cage an sham controls. peak blood carboxyhemoglobin (cohb) levels measured immediately after smoking showed levels of 0.5+/- 0.1%, 3.6+/-1.0%, and 5.7+/-2.8% for sham cont ...19826951581
characterization of sulphated monosaccharides from stumptail monkey (macaca arctoides) salivary mucin. 19816946739
direct measurement of loads at the temporomandibular joint in macaca arctoides.this paper describes a novel technique of directly measuring loads at the condyle in macaca arctoides and provides recordings on one animal while measuring loads at the tmj. this study is the first to actually measure loads directly at the articulating surfaces of the condyle. the data collected in this study confirm hylander's data that the tmj is a stress-bearing joint. with this pilot study, observations which can be made are: 1) the loads at the condyle are minimal during posterior chewing o ...19816944346
immune response to keyhole limpet hemocyanin and oral actinomyces viscosus antigens in macaca arctoides.the humoral and cell-mediated immune response to keyhole limpet hemocyanin and antigens from a monkey oral strain of actinomyces viscosus were investigated in macaca arctoides. prior to immunization no responses were detected. immunization resulted in the production of antibodies to both antigen preparations, the development of a positive skin test and significant stimulation of peripheral blood lymphocytes using the in vitro lymphocyte blastogenesis technique. furthermore, these responses were ...19816939831
plasma and liver carnitine (free and esterified) levels and their interrelationships in moderately hypercholesterolemic monkeys (macaca arctoides).the level of carnitine and its esters was measured in plasma and liver in 20 male stump-tailed monkeys (macaca arctoides) that were fed a moderately hypercholesterolemic diet. plasma total carnitine was 60 +/- 3 nmol/ml (30% esterified) and liver total carnitine was 254 +/- 15 nmol/g wet weight (16% esterified) or 1.28 +/- 0.07 nmol/mg noncollagen protein. the plasma concentration of total carnitine was positively correlated with the total carnitine concentration of the livers (r = 0.71, p less ...19836883165
submitral atheromatous lesions in monkey and man.posterior submitral recess (psmr) calcification is a common autopsy finding in elderly people, but its pathogenesis is undetermined. in this communication we show that, in part at least, the psmr changes at autopsy are atheroma-like with lipid around the sclerosis and calcific deposits. these changes in the psmr showed a statistically significant correlation with the presence of hypertension and with an autopsy finding of severe coronary atherosclerosis. we showed, for the first time, that simil ...19836851271
protection of normal tissues with 2-aminoethylisothiouronium during local pelvic radiation in monkeys.intestinal and bladder injury are the main limiting factors to radiation therapy in patients with pelvic neoplasms. 2-amino-ethylisothiouronium (aet) is a radiation-protective agent when given systemically but absorbs poorly from the intestines. accordingly, it was explored for the local protection of the bowel and bladder during radiation to the pelvis. radiation localized to the pelvis in various high fractionated doses and various schedules was applied to pairs of stumptailed monkeys (macaca ...19836850597
effect of oestrogen on gonadotrophin release in stumptailed monkeys (macaca arctoides) treated chronically with an agonist analogue of luteinizing hormone releasing hormone.nine adult female stumptailed monkeys (macaca arctoides) treated chronically with daily s.c. injections of d-ser(but)6,des-gly10,proethylamide9, luteinizing hormone releasing hormone (lh-rh agonist) to inhibit ovulation, were tested for their ability to respond to an oestrogen provocation test (positive feedback). on two occasions during treatment with the lh-rh agonist (first test between 10 and 35 weeks after treatment had started; second test between 30 and 60 weeks after) the animals were gi ...19816799604
ultrastructure of differentiating preameloblasts from tooth germs of the permanent dentition of macaca mulatta and macaca arctoides.cytodifferentiation of inner enamel epithelium and the adjacent connective tissue from the tip of the cervical loop to the initiation of enamel elaboration in two macaca species was examined. ten- to twelve-month-old specimens were fixed by perfusion and the permanent tooth buds were prepared for transmission electron microscopy. at the cervical loop proper, inner enamel epithelium cells have lobed nuclei, a paucity of cytoplasm, and wide extracellular spaces; the basal lamina facing the dental ...19816799172
lactose intolerance in the stumptail macaque (macaca arctoides): case report.a female stumptail macaque had signs of intermittant diarrhea and chronic weight loss over a 2-year period during which she was fed a commercial laboratory maintenance diet. intolerance of this individual to lactose, a ubiquitous constituent of most commercial primate diets, was diagnosed on the basis of lactose tolerance tests and favorable clinical response to dietary carbohydrate substitution with glucose. oral administration of varying doses of glucose to this animal consistently produced el ...19806772876
naloxone-induced electrographic seizures in the primate.electrographic seizure activity was recorded shortly following naxolone injections in artificially ventilated, methadone-treated stump-tailed macaques. plasma-methadone concentrations prior to seizure activity were many times higher than those that have produced respiratory depression and death in nonventilated monkeys. the duration of seizure activity was clearly related to the dose of naloxone. naloxone was without epileptogenic properties in animals that had not been pretreated with methadone ...19806770398
periovulatory endocrine events in the stumptailed monkey (macaca arctoides).blood samples were obtained frequently from stumptailed monkeys (macaca arctoides) at midcycle and assayed for fsh, lh, 17 beta-estradiol, and progesterone. periovulatory endocrine events were generally similar to those which have been described in rhesus monkeys and women. although the midcycle patterns of estradiol in individual monkeys appeared quite varied, careful evaluation indicated the following general characteristics: 1) a plateau or transient decline in estradiol 30-44 h before the lh ...19806769663
pathogenicity testing of macaca arctoides subgingival plaque following chlorhexidine treatment.potential infectivity of subgingival plaque of macaca arctoides in guinea pig leg muscle was examined before, during, and after chlorhexidine treatment. the regime of chlorhexidine administration did not appear to alter the monkey subgingival microflora markedly and had no demonstrable effects on the pathogenicity of the subgingival plaque. these data confirm previous suggestions that chlorhexidine essentially does not penetrate into the deeper part of periodontal pockets following a supragingiv ...19806767837
decreased pituitary responsiveness and inhibition of the luteinizing hormone surge and ovulation in the stumptailed monkey (macaca arctoides) by chronic treatment with an agonist of luteinizing hormone-releasing hormone. 19806766380
simian varicella infection in the african green monkey (cercopithecus aethiops).a severe and highly fatal disease occurred in african green monkeys (cercopithecus aethiops). the disease was marked by an extensive maculo-vesicular rash. in fatal cases, multifocal necrosis and hemorrhage were found characteristically in many organs and tissues. new cases of the disease occurred over a 39-day period. nine of 49 exposed african green monkeys were affected and five of the nine died. four cynomolgus (macaca fascicularis) and 31 stumptailed monkeys (macaca arctoides) which were ex ...19846748606
neuronal activity of the locus ceruleus in awake macaca arctoides.neuronal activity in the locus ceruleus of awake, behaving stump-tailed monkeys increased consistently and vigorously after presentation of mildly aversive and threatening stimuli. these preliminary data increase the range of stimuli reported to elicit locus ceruleus activity in awake monkeys to include nonpainful threat signals and suggest that more studies are needed to be able to categorize locus ceruleus function from its unit activity responses.19846723890
ascaris-induced bronchoconstriction in primates experimentally infected with ascaris suum ova.bronchial provocation with ascaris allergen evoked bronchoconstriction in home-bred macaca arctoides monkeys sensitized by experimental infection with embryonated ascaris suum ova. inhalation of ascaris allergen by aerosol prior to infection produced no changes in lung function. in infected animals total lung resistance (rl) increased and dynamic lung compliance (cdyn) decreased following ascaris inhalation. the changes in lung function reached a peak, 2-5 min after allergen inhalation, lasted f ...19836652969
labeled choline and phosphorylcholine: body distribution and brain autoradiography: concise communication.following intravenous injection of labeled choline or phosphorylcholine in rats and mice, the brain uptake as percent injected dose was less than 0.2% with 6-12% going to kidney and 3-6% to liver. a study of [14c]choline autoradiography in a stump-tailed macaque demonstrated a five- to sixfold greater uptake in gray matter than in white matter. dynamic positron imaging of [11c]choline in a rhesus monkey demonstrated rapid brain uptake followed by rapid washout, with heavy late uptake in muscle. ...19836604143
hyperkalemia in cardioplegic solutions causing increased cholesterol accumulation in vein grafts.hyperkalemic cardioplegic solutions are frequently infused through vein grafts during aorta-coronary bypass operations. although some reports have suggested the potential for physical damage to grafts by such exposure, the effects of these solutions on graft atherogenesis have not been studied. we evaluated the influence of potassium and colloid content of cardioplegic solutions on graft cholesterol accumulation in our established animal model of graft atherogenesis. fourteen cephalic vein graft ...19836601215
effect of sodium meclofenamate on radiation-induced esophagitis and cystitis.stumptailed monkeys (macaca arctoides) received 2000 rad irradiation to the upper half of the esophagus and to the bladder by a 6-mev linear accelerator. endoscopy and biopsy was obtained from these organs weekly for 3 weeks. at the end of this period, the animals were autopsied and histopathologic examination undertaken. sodium meclofenamate in doses of 5-20 mg/kg/day p.os was found effective in reducing or preventing radiation induced esophagitis and cystitis.19846595342
cellular fatty acid and soluble protein profiles of oral fusobacteria.we compared the cellular fatty acid and protein content of 43 strains of oral fusobacteria isolated from patients with chronic gingivitis, acute necrotizing ulcerative gingivitis, and juvenile and adult periodontitis, as well as from the stump-tailed macaque, to that of eight reference strains of oral and non-oral fusobacterium species. a gas-liquid chromatographic examination of trimethylsilyl derivatives of the fatty acid methyl esters revealed n14:0, 3-oh-14:0, n16:0, 16:1, 3-oh-16:0, n18:0, ...19836581193
role of vision in social development in monkeys.8 stump-tailed macaques were reared individually and either given all of their daily social experience in darkness (dark group) or given half their social experience in the dark and half in the light (controls). the dark group showed almost no aggressive behavior and less play than controls. later, when all were tested in the light, the dark group were still less aggressive. controls were less aggressive in the dark than in the light. there was no difference between the two groups in the form of ...19846541561
contrasting effects of d-amphetamine on affiliation and aggression in monkeys.amphetamine has been observed to alter conditioned or learned behavior in individually housed animals, as well as naturally-occurring behavior characteristic of animals living in groups. this study is concerned with the effects of d-amphetamine on affiliative and aggressive behavior in adult male stumptail macaques (macaca arctoides) living in a large, heterogeneous social group. using standardized observational techniques, the affiliative and aggressive behaviors initiated by five adult male mo ...19846538973
a primate model of human postmenopausal hot flushes.the hot flush is the only symptom specifically attributable to the menopause. hot flushes appear to represent an episodic derangement of thermoregulation as a result of estrogen deficiency but the underlying physiological mechanisms are unknown. we have developed an animal model for the study of hot flushes. two female monkeys (macaca arctoides) were trained to accept monitoring of scalp cutaneous temperatures. after baseline temperature recordings were obtained both monkeys were ovariectomized. ...19846490799
ocular blood flow in phakic and aphakic monkey eyes.alterations in regional ocular blood flow produced by topical epinephrine were studied in phakic and aphakic eyes of macaca arctoides using the radioactive microsphere technique. three isotopes were used to make sequential blood flow measurements just prior to topical epinephrine administration, 1 hr later and 3 hr later. significant reductions of flow were found in the iris, ciliary body, and optic nerve head of both phakic and aphakic groups. choroidal and posterior optic nerve flow decreased ...19846479247
sexual behavior of group-housed stumptail macaques (macaca arctoides): temporal, demographic and sociosexual relationships.a detailed quantitative analysis of sexual behavior in a social group of captive stumptail macaques was conducted. the distribution of copulations both over days and among animals, and the relationships between copulation and various sociosexual patterns were investigated. copulations occurred erratically over days and were preferentially directed to a small minority of females. most patterns of sociosexual behavior were at their highest rates during actual copulatory episodes, others occurred i ...19846469150
an inverse relationship between plasma carnitine and triglycerides in selected macaca arctoides and macaca nemistrina fed a low-fat chow diet.plasma carnitine and triglycerides were measured in five male macaca arctoides and one female macaca nemistrina during the course of feeding a low-fat (5.2% w/w), high carbohydrate diet and a high-fat (15.9% w/w), low carbohydrate diet. for each individual monkey, an inverse relationship was observed between plasma carnitine and triglyceride levels when the low-fat diet was fed but not when the high-fat diet was fed. the mechanism of the different responses to diet was not investigated but may b ...19846467897
chemical castration with cyproterone acetate (androcur) and sexual behavior in the laboratory-housed male stumptailed macaque (macaca arctoides). 19816459586
the distribution of serum high density lipoprotein subfractions in non-human primates.the ultracentrifugal flotation patterns in 1.2 g/ml solvent and ultracentrifugal gradient distribution of high density lipoproteins (hdl) from the primates--human, apes and monkeys--were determined, with emphasis on the gorilla species of apes and rhesus monkeys. diets for non-human primates were commercial chow, which is low in cholesterol. molecular weights and protein, cholesterol, phospholipid and triglyceride compositions of various density fractions were determined on human, gorilla and rh ...19846438429
effect of treatment for 1 year with a luteinizing hormone-releasing hormone agonist on ovarian, thyroidal, and adrenal function and menstruation in the stumptailed monkey (macaca arctoides). 19836401177
characterisation of a polyomavirus in two foetal rhesus monkey kidney cell lines used for the growth of hepatitis a virus.electron microscopy and prolonged incubation of cell cultures have revealed the presence of a papovavirus in two foetal rhesus monkey kidney cell lines, frhk-4 and frhk-6, which are used to grow hepatitis a virus. the papovavirus, designated frkv, was present in culture fluids from both cell lines and in thin sections of frhk-4 cells. the size of the virus, 47 nm, places frkv within the polyomavirus genus. frkv has been grown in primary human embryo kidney and calf kidney cell cultures. haemaggl ...19846326710
isolation and characterization of a papovavirus from cynomolgus macaque kidney cells.a papovavirus was isolated from uninoculated kidney cell cultures of the cynomolgus macaque (macaca fascicularis), in which it produced extensive cytopathologic changes after prolonged periods of culturing. on basis of virion morphology, genome size, and restriction endonuclease data, this virus was identified as a new isolate of the stump-tailed macaque virus (stmv) and subsequently named ck-strain (cynomolgus kidney) of stmv. without inducing c.p.e. the virus replicated also in bsc-1, vero, hu ...19846324474
[etiological aspects of leukemias in primates including man].attempts have been made to induce viral leukemia in monkeys (papio hamadryas and macaca arctoides) by inoculating them with blood from humans with different types of leukemias. in hamadryas baboons, the disease spread horizontally. by today 218 p. hamadryas and 5 m. arctoides monkeys had died of malignant lymphoma. the following viruses have been isolated from sick monkeys: lymphotropic baboon herpes virus (hvp), endogenous baboon c type viruses--xenotropic (biln), and ecotropic (evpg). c type o ...19836318850
evidence for a bovine origin of the polyomavirus detected in foetal rhesus monkey kidney cells, frhk-4 and -6.rabbit antisera to the stump-tailed macaque polyomavirus (stmv) which had been shown by immunoelectron microscopy and indirect immunofluorescence to react with the polyomavirus found in frhk-4 cells (frkv), also gave precipitin lines in counter-immunoelectrophoresis (cie) and double diffusion in gel (gd) when reacted with frkv. the reactions in gd showed identity with that of a rabbit antiserum to frkv. naturally occurring antibody to frkv (anti-frkv) was found by cie in 48 per cent of 353 cattl ...19836318690
efficient isolation of endogenous rhesus retrovirus from trophoblast.an examination of various rhesus monkey (macaca mulatta) organs has shown a preference for type c viral antigen expression in the placenta. separate cocultivations of isolated trophoblasts from 10 rhesus monkey placentas with cell lines from heterologous mammalian species led to rapid isolation of type c rhesus retrovirus in 4 of 10 cases. these four retrovirus isolates have been designated mmc-2 through mmc-5. five of the remaining six sets of cocultivations grew simian foamy virus and were dis ...19836310872
acute gastric dilation and rupture in macaca arctoides associated with clostridium perfringens.a clinical case of gastric dilation and rupture is described in an adult male macaca arctoides. clostridium perfringens was isolated from the heart blood and liver. data collected from our macaque colony for 13 years indicated a mortality rate of 3.5% due to acute dilation.19816283084
structural homology of the major internal proteins of endogeneous type c viruses of two distantly related species of old world monkeys: macaca arctoides and colobus polykomos. 19816274085
catechol estrogen formation in placental and fetal tissues of humans, macaques, rats and rabbits.placental and fetal tissues obtained from humans, monkeys, rats and rabbits contained monooxygenases capable of catalyzing the formation of catechol estrogens. treatments of pregnant rats with phenobarbital, aroclor 1254, or 3-methylcholanthrene each increased measured rates of catechol estrogen formation in placentas, fetal brains and fetal livers, while other rat tissues exhibited either increased or decreased activity. treatment of pregnant rabbits with arocolor 1254 produced an increase in c ...19816265171
sertoli-leydig cell communication via an lhrh-like factor.the primary function of the testosterone secreted by leydig cells is the maintenance of spermatogenesis and hence fertility. this action of testosterone is mediated by the sertoli cells which nourish and support the developing spermatozoa. as normal sertoli cell function is so critically dependent on normal leydig cell function, a regulatory influence of the sertoli cells on the leydig cells has been suggested. indeed, follicle-stimulating hormone (fsh), which acts only on sertoli cells, can als ...19816261155
studies on platelet aggregation inhibitors in vivo. x. relationship to thrombolysis.human labeled fibrin clots were inserted into femoral veins of stumptailed monkeys (macaca arctoides). thrombolysis was slightly increased by treatment with the platelet aggregation inhibitor pentoxifylline. this agent significantly potentiated the thrombolytic effect of urokinase activated human plasminogen. pentoxifylline was also found to release plasminogen activator activity into the circulation.19826221055
hypersensitivity pneumonitis in nonhuman primates. i. studies on the relationship of immunoregulation and disease activity.we investigated the relationship of immunoregulation to disease activity in a nonhuman primate model of pigeon breeder's disease. two macaca arctoides monkeys developed classical symptoms of hypersensitivity pneumonitis after sensitization and prolonged bronchial challenge, whereas 2 other monkeys remained asymptomatic after in vivo challenge. there were no differences in the percentages of t cells, b cells, monocytes, or fc gamma-bearing t cells between symptomatic and asymptomatic animals. non ...19826172473
breeding the stump-tailed macaque, macaca arctoides. 19705005920
cholesterol ester content of the serum: alterations due to simple and complex carbohydrate diets in nonhuman primates (cebus albifrons, macaca arctoides, and macaca mulatta). 19715003646
amygdalectomy and social behavior in the caged stump-tailed macaque (macaca speciosa). 19714996920
studies of common baldness of the stump-tailed macaque (macaca speciosa). vi. the effect of testosterone on common baldness. 19714996316
[abnormal behaviour in macagues (macaca arctoides)]. 19704990831
complementary specialization of male and female reproductive structures in the bear macaque, macaca arctoides. 19674964196
two-trial learning-set formations by baboons and by stump-tailed macaques. 19654953535
peripheral serum progesterone and correlated endometrial glycogen levels during the menstrual cycle of macaca arctoides. 19734688106
duration of the cycle of the seminiferous epithelium and the spermatogonial renewal in the monkey macaca arctoides. 19734684877
experimental analysis of causal relationships between grooming behavior and inter-individual proximity in the stumptailed macaque (macaca arctoides): a preliminary report. 19734632100
visual and tactile communication in macaca arctoides and its ontogenetic development. 19734632097
hormonal control of endometrial glycogen metabolism in the macaca arctoides. 19734632068
retention of spatial alternation following frontal lobe resections in stump-tailed macaques. 19724628085
the postacrosomal region of the spermatozoa of man and macaca arctoides. 19724626323
the cervix uteri in macaca mulatta, macaca arctoides, and macaca fascicularis--a comparative anatomic study with special reference to macaca arctoides as a unique model for endometrial study. 19724625654
spontaneous osteogenic sarcoma in a stumptail (macaca arctoides) monkey. 19724504483
the human spermatozoon. an electron microscopical study including comparative details of macaca arctoides spermatozoa. 19744362603
virus from stumptailed monkey (macaca arctoides) kidney cultures. 19744360747
normal serum biochemical values of macaca arctoides, macaca fascicularis, and macaca radiata. 19714332167
idiopathic muscle necrosis with apparent myoglobinuria in macaca arctoides. 19714325698
acute bloat syndrome in stumptailed macaques (macaca arctoides): a report of four cases. 19714325689
endocardial fibrosis associated with monocrotaline-induced pulmonary hypertension in nonhuman primates (macaca arctoides). 19734271643
experimental brucella canis infection in the monkey (macaca arctoides).four stumptail macaque monkeys (macaca arctoides) were each inoculated with approximately 10(10) organisms from a culture of brucella canis. two animals were inoculated via the oral and conjunctival route and the other two monkeys were inoculated intravenously with the organisms. a fifth animal served as a control. blood samples were taken at weekly intervals for hematological, serological and bacterialogical studies. the monkeys were killed at five and ten weeks post-inoculation and tissues tak ...19724261836
physaloptera tumefaciens in the stump-tailed macaque (macaca arctoides). 19704247976
blood values in stumptailed macaques (macaca arctoides) under laboratory conditions. 19704247043
certain hematologic and blood chemical values in adult stumptailed macaques (macaca arctoides). 19704244731
an occurrence of monozygotic twinning and anencephaly in macaca arctoides. 19694240739
studies of common baldness in the stump-tailed macaque. v. regional difference of testosterone metabolites in the hair follicles. 19744218849
harassment of sexual behavior in the stumptail macaque, macaca arctoides. 19744215713
some causal factors in autogrooming behaviour of adult stump-tailed macaques (macaca arctoides). 19744208110
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