Publications

differences in larval nutritional requirements and female oviposition preference reflect the order of fruit colonization of zaprionus indianus and drosophila simulans.	species coexist using the same nutritional resource by partitioning it either in space or time, but few studies explore how species-specific nutritional requirements allow partitioning. zaprionus indianus and drosophila simulans co-exist in figs by invading the fruit at different stages; z. indianus colonizes ripe figs, whereas d. simulans oviposits in decaying fruit. larvae feed on yeast growing on the fruit, which serves as their primary protein source. because yeast populations increase as fr ...	2015	26358399
expression divergence of chemosensory genes between drosophila sechellia and its sibling species and its implications for host shift.	drosophila sechellia relies exclusively on the fruits of morinda citrifolia, which are toxic to most insects, including its sibling species drosophila melanogaster and drosophila simulans. although several odorant binding protein (obp) genes and olfactory receptor (or) genes have been suggested to be associated with the d. sechellia host shift, a broad view of how chemosensory genes have contributed to this shift is still lacking. we therefore studied the transcriptomes of antennae, the main org ...	2015	26430061
maternal effect and speciation: maternal effect contributes to the evolution of hybrid inviability between drosophila simulans and drosophila mauritiana.	haldane's rule has been the basis of speciation research during the last 30 years. most studies have focused on the nature of incompatibilities in the hybrid male, but not much attention has been given to the genetic basis of fertility and inviability in hybrid females. hybridizations between drosophila simulans and drosophila mauritiana produce fertile females and sterile males. here, we re-examined the level of fertility in reciprocal f1 females of these two species and looked for the presence ...	2015	26436586
comparative population genomics of latitudinal variation in drosophila simulans and drosophila melanogaster.	examples of clinal variation in phenotypes and genotypes across latitudinal transects have served as important models for understanding how spatially varying selection and demographic forces shape variation within species. here, we examine the selective and demographic contributions to latitudinal variation through the largest comparative genomic study to date of drosophila simulans and drosophila melanogaster, with genomic sequence data from 382 individual fruit flies, collected across a spatia ...	2016	26523848
inference of directional selection and mutation parameters assuming equilibrium.	in a classical study, wright (1931) proposed a model for the evolution of a biallelic locus under the influence of mutation, directional selection and drift. he derived the equilibrium distribution of the allelic proportion conditional on the scaled mutation rate, the mutation bias and the scaled strength of directional selection. the equilibrium distribution can be used for inference of these parameters with genome-wide datasets of "site frequency spectra" (sfs). assuming that the scaled mutati ...	2015	26597774
genomic patterns of geographic differentiation in drosophila simulans.	geographic patterns of genetic differentiation have long been used to understand population history and to learn about the biological mechanisms of adaptation. here we present an examination of genomic patterns of differentiation between northern and southern populations of australian and north american drosophila simulans, with an emphasis on characterizing signals of parallel differentiation. we report on the genomic scale of differentiation and functional enrichment of outlier snps. while, ov ...	2016	26801179
rapid evolution of a y-chromosome heterochromatin protein underlies sex chromosome meiotic drive.	sex chromosome meiotic drive, the non-mendelian transmission of sex chromosomes, is the expression of an intragenomic conflict that can have extreme evolutionary consequences. however, the molecular bases of such conflicts remain poorly understood. here, we show that a young and rapidly evolving x-linked heterochromatin protein 1 (hp1) gene, hp1d2, plays a key role in the classical paris sex-ratio (sr) meiotic drive occurring in drosophila simulans driver hp1d2 alleles prevent the segregation of ...	2016	26979956
interspecific y chromosome variation is sufficient to rescue hybrid male sterility and is influenced by the grandparental origin of the chromosomes.	y chromosomes display population variation within and between species. co-evolution within populations is expected to produce adaptive interactions between y chromosomes and the rest of the genome. one consequence is that y chromosomes from disparate populations could disrupt harmonious interactions between co-evolved genetic elements and result in reduced male fertility, sterility or inviability. here we address the contribution of 'heterospecific y chromosomes' to fertility in hybrid males car ...	2016	26980343
hybrid dysgenesis in drosophila simulans associated with a rapid invasion of the p-element.	in a classic example of the invasion of a species by a selfish genetic element, the p-element was horizontally transferred from a distantly related species into drosophila melanogaster. despite causing 'hybrid dysgenesis', a syndrome of abnormal phenotypes that include sterility, the p-element spread globally in the course of a few decades in d. melanogaster. until recently, its sister species, including d. simulans, remained p-element free. here, we find a hybrid dysgenesis-like phenotype in th ...	2016	26982327
the first complete mag family retrotransposons discovered in drosophila.	a retrotransposon of the mag family was found in the drosophila simulans genome for the first time. we also identified novel transposable elements representing the mag family in seven drosophila species. the high similarity between the 3' and 5' long terminal repeats in the found copies of transposable elements indicates that their retrotransposition has occurred relatively recently. thus, the mag family of retrotransposons is quite common for the genus drosophila.	2016	27025475
correction: hybrid dysgenesis in drosophila simulans associated with a rapid invasion of the p-element.	[this corrects the article doi: 10.1371/journal.pgen.1005920.].	2016	27166958
a genomic approach to identify hybrid incompatibility genes.	uncovering the genetic and molecular basis of barriers to gene flow between populations is key to understanding how new species are born. intrinsic postzygotic reproductive barriers such as hybrid sterility and hybrid inviability are caused by deleterious genetic interactions known as hybrid incompatibilities. the difficulty in identifying these hybrid incompatibility genes remains a rate-limiting step in our understanding of the molecular basis of speciation. we recently described how whole gen ...	2016	27230814
few genetic and environmental correlations between life history and stress resistance traits affect adaptation to fluctuating thermal regimes.	laboratory selection in thermal regimes that differed in the amplitude and the predictability of daily fluctuations had a marked effect on stress resistance and life history traits in drosophila simulans. the observed evolutionary changes are expected to be the result of both direct and correlated responses to selection. thus, a given trait might not evolve independently from other traits because of genetic correlations among these traits. moreover, different test environments can induce novel g ...	2016	27273321
tropical drosophila pandora carry wolbachia infections causing cytoplasmic incompatibility or male killing.	wolbachia infections have been described in several drosophila species, but relatively few have been assessed for phenotypic effects. cytoplasmic incompatibility (ci) is the most common phenotypic effect that has been detected, while some infections cause male killing or feminization, and many wolbachia infections have few host effects. here, we describe two new infections in a recently described species, drosophila pandora, one of which causes near-complete ci and near-perfect maternal transmis ...	2016	27282489
neighboring genes for dna-binding proteins rescue male sterility in drosophila hybrids.	crosses between closely related animal species often result in male hybrids that are sterile, and the molecular and functional basis of genetic factors for hybrid male sterility is of great interest. here, we report a molecular and functional analysis of hms1, a region of 9.2 kb in chromosome 3 of drosophila mauritiana, which results in virtually complete hybrid male sterility when homozygous in the genetic background of sibling species drosophila simulans. the hms1 region contains two strong ca ...	2016	27357670
natural courtship song variation caused by an intronic retroelement in an ion channel gene.	animal species display enormous variation for innate behaviours, but little is known about how this diversity arose. here, using an unbiased genetic approach, we map a courtship song difference between wild isolates of drosophila simulans and drosophila mauritiana to a 966 base pair region within the slowpoke (slo) locus, which encodes a calcium-activated potassium channel. using the reciprocal hemizygosity test, we confirm that slo is the causal locus and resolve the causal mutation to the evol ...	2016	27509856
constrained evolution of the sex comb in drosophila simulans.	male fitness is dependent on sexual traits that influence mate acquisition (precopulatory sexual selection) and paternity (post-copulatory sexual selection), and although many studies have documented the form of selection in one or the other of these arenas, fewer have done it for both. nonetheless, it appears that the dominant form of sexual selection is directional, although theoretically, populations should converge on peaks in the fitness surface, where selection is stabilizing. many factors ...	2017	27859860
structure and ultrastructure of spermatozoon in six species of drosophilidae (diptera).	the drosophilidae family is formed by brachycera diptera distributed widely across different regions of the planet. it is composed of about 4000 species, 304 of which are found in brazil. the objective of this work was to characterize morphologically the structure of the male internal reproductive apparatus and the ultrastructure of the spermatozoon in four neotropical (drosophila cardini, d. mercatorum, d. nebulosa and d. sturtevanti) and two invasive (d. simulans and zaprionus indianus) specie ...	2016	28029387
sex-biased transcriptome divergence along a latitudinal gradient.	sex-dependent gene expression is likely an important genomic mechanism that allows sex-specific adaptation to environmental changes. among drosophila species, sex-biased genes display remarkably consistent evolutionary patterns; male-biased genes evolve faster than unbiased genes in both coding sequence and expression level, suggesting sex differences in selection through time. however, comparatively little is known of the evolutionary process shaping sex-biased expression within species. latitu ...	2017	28100025
does pupal communication influence wolbachia-mediated cytoplasmic incompatibility?	wolbachia are widespread endosymbiotic bacteria found in terrestrial arthropods and filarial nematodes [1]. in insects, wolbachia generally rely on diverse strategies to manipulate their host's reproduction and favor their own vertical transmission through infected eggs [2]. one such mechanism is a sterility syndrome called 'cytoplasmic incompatibility'. cytoplasmic incompatibility occurs at fertilization, when a spermatozoon from a wolbachia-infected male fertilizes an uninfected egg. in this c ...	2017	28118585
genetic and transgenic reagents for drosophila simulans, d. mauritiana, d. yakuba, d. santomea, and d. virilis.	species of the drosophila melanogaster species subgroup, including the species d. simulans, d. mauritiana, d. yakuba, and d. santomea, have long served as model systems for studying evolution. however, studies in these species have been limited by a paucity of genetic and transgenic reagents. here, we describe a collection of transgenic and genetic strains generated to facilitate genetic studies within and between these species. we have generated many strains of each species containing mapped pi ...	2017	28280212
clonal analysis in hybrids between drosophila melanogaster and drosophila simulans.	we have analysed the viability of cellular clones induced by mitotic recombination in drosophila melanogaster/d. simulans hybrid females during larval growth. these clones contain a portion of either melanogaster or simulans genomes in homozygosity. analysis has been carried out for the x and the second chromosomes, as well as for the 3l chromosome arm. clones were not found in certain structures, and in others they appeared in a very low frequency. only in abdominal tergites was a significant n ...	1994	28305934
alcohol tolerance: an ecological parameter in the relative success of drosophila melanogaster and drosophila simulans.	laboratory experiments have shown d. melanogaster adults to be more tolerant to alcohol in the environment than d. simulans, with the females being more tolerant than the males of their species. larval development on alcohol supplemented media also demonstrated an increased tolerance by d. melanogaster although the effect was not as clear cut as for the adult survival. oviposition choice experiments demonstrated a marked rejection of alcohol impregnated laying sites by d. simulans when compared ...	1972	28307067
adult population density, fecundity and productivity in drosophila melanogaster and drosophila simulans.	single-species cultures of d. melanogaster oregon-r-c and d. simulans v were set up with 5, 50, 100, 200, 300 or 400 pairs of parents. these parents were discarded after 48 hours, and the numbers and wet weights of emerging progeny recorded twice daily. for each culture, the fitness components estimated were total number of progeny, total progeny biomass, average male and average female wet weights, mean developmental period, and sex ratio. d. melanogaster had higher progeny productivity and lon ...	1973	28307208
genetics and the environment in interspecific competition: a study using the sibling species drosophila melanogaster and drosophila simulans.	the outcome of interspecific competition of two closely related species may depend upon genetic variation in the two species and the environment in which the experiment is carried out. interspecific competition in the two sibling species, drosophila melanogaster and d. simulans, is usually investigated using longterm laboratory stocks that often have mutant markers that distinguish them. to examine competition in flies that genetically more closely resemble flies in nature, we utilized freshly c ...	1996	28307735
the distribution of vineyard populations of drosophila melanogaster and drosophila simulans during vintage and non-vintage periods.	field studies inside and outside the cellars of the "chateau tahbilk" vineyard have substantiated the distribution data of original collections. d. melanogaster is found inside and outside the cellars while d. simulans is only collected outside. the presence of alcohol fumes in the outside environment during vintage alters the distribution of the species, relative to non-vintage periods, with d. melanogaster being closer to the source. mark-release-recapture experiments suggest that movement by ...	1974	28308614
larval reaction to alcohol as an indicator of resource utilization differences between drosophila melanogaster and d. simulans.	newly hatched larvae of drosophila melanogaster derived from southern australian populations (37-38° s) have a strong preference for agar containing alcohol, while larvae of sympatric populations of drosophila simulans show no initial preference. the alcohol preference of a more northern d. melanogaster population (10° s) is lower due to a high level of variability among isofemale strains. this agree with the general principle of decreasing biological diversity with increasing latitude, and is s ...	1977	28309429
preadult competition between colonizing populations of drosophila subobscura and established populations of drosophila simulans in chile.	the palearctic species drosophila subobscura was detected for the first time in chile and probably in the americas in 1978. at present, its distribution area extends between 29°54's and 53°40's, where it has become abundant in both domestic and wild environments, depending on the latitude and the season of the year (appearing at maximum frequency in early spring). the seasonal fluctuations of d. subobscura are the inverse of those of d. simulans, which shares the same habitat in certain regions. ...	1983	28310659
ecological differences and competitive interaction between drosophila melanogaster and drosophila simulans in small laboratory populations.	in interspecific competition studies, some cases of apparent change in competitive ability have been reported. but the change in competitive outcome could equally well be due to character displacement. as a preliminary to studies of the effects of association of d. melanogaster (yellow white mutant strain) and d. simulans (vermilion mutant strain), the nature and extent of ecological differences between them, and the nature of their competitive interaction was studied. differences between the st ...	1971	28313277
structure of the transcriptional regulatory network correlates with regulatory divergence in drosophila.	transcriptional control of gene expression is regulated by biochemical interactions between cis-regulatory dna sequences and trans-acting factors that form complex regulatory networks. genetic changes affecting both cis- and trans-acting sequences in these networks have been shown to alter patterns of gene expression as well as higher-order organismal phenotypes. here, we investigate how the structure of these regulatory networks relates to patterns of polymorphism and divergence in gene express ...	2017	28333240
interaction between female and male parts in gynandromorphs of drosophila simulans.		1931	28354041
transcriptional polymorphism of pirna regulatory genes underlies the mariner activity in d. simulans testes.	during colonization of new areas, natural populations have to deal with changing environments, and transposable elements (tes) can be useful "tools" in the adaptation process since they are major contributor to the structural and functional evolution of genomes. in this general context, the activity (copy number, transcriptional and excision rate) of the mariner mos1 element was estimated in 19 natural populations of d. simulans. it is shown (1) that mos1 expression is always higher and more var ...	2017	28401606
drosophila simulans: a species with improved resolution in evolve and resequence studies.	the combination of experimental evolution with high-throughput sequencing of pooled individuals-i.e., evolve and resequence (e&r)-is a powerful approach to study adaptation from standing genetic variation under controlled, replicated conditions. nevertheless, e&r studies in drosophila melanogaster have frequently resulted in inordinate numbers of candidate snps, particularly for complex traits. here, we contrast the genomic signature of adaptation following ∼60 generations in a novel hot environ ...	2017	28546383
temperature effects on life history variation in drosophila simulans.		1983	28556002
studies on natural populations of drosophila vi. competition between drosophila melanogaster and drosophila simulans.		1967	28556108
unidirectional incompatibility between populations of drosophila simulans.	drosophila simulans females from a strain collected at watsonville, ca produce very few offspring when mated with males from a strain collected at riverside 510 km away. this incompatibility does not exist in the reciprocal cross. in the incompatible cross, mating and oviposition are normal, but eggs fail to hatch. a survey of other california populations indicates that unidirectional incompatibility is widespread. the incompatibility is maternally inherited over one generation. using older rive ...	1986	28556160
evolutionary genetics of two sibling species, drosophila simulans and d. sechellia.	drosophila simulans and d. sechellia are sibling species, the former cosmopolitan and the latter restricted to the seychelles islands. we used classical genetic analysis to measure the numbers and effects of genes responsible for reproductive isolation and morphological differences in male genitalia between these species. at least five loci are responsible for male sterility in hybrids, with the strongest effects produced by at least two genes on the x chromosome. at least three (and probably fo ...	1986	28556167
effects of parental photoperiod regime on progeny development time in drosophila simulans.		1986	28556320
race formation, speciation, and introgression within drosophila simulans, d. mauritiana, and d. sechellia inferred from mitochondrial dna analysis.	mitochondrial dna cleavage maps from three chromosomally homosequential species drosophila simulans, d. mauritiana, and d. sechellia, were established for 12 restriction enzymes. one isofemale strain was studied in d. sechellia (se), 13 in d. simulans, and 17 in d. mauritiana: in the last two species, respectively, three (sii, ii, and iii) and two (mai and ii) cleavage morphs were found. the evolutionary relationships based on mtdna cleavage map comparisons show that the mai and se mtdnas are in ...	1986	28556334
oviposition site selection by drosophila melanogaster and drosophila simulans.	the effects of texture and larval residues in the medium on oviposition site selection (oss) by drosophila melanogaster and drosophila simulans were studied. drosophila melanogaster laid over 95% of its eggs in sieved medium (vs. unsieved medium); d. simulans laid all of its eggs in sieved medium. surgical removal of antennal segments, and of fore-, mid-, or hindtarsi did not affect this result, indicating that sense organs involved in discriminating between sieved and unsieved medium are not co ...	1985	28561364
genes affecting courtship song and mating preference in drosophila melanogaster, drosophila simulans and their hybrids.		1981	28563392
mitochondrial dna polymorphism and cytoplasmic incompatibility in natural populations of drosophila simulans.		1990	28563884
the sex-ratio trait in drosophila simulans: geographical distribution of distortion and resistance.	the sex-ratio trait we describe here in drosophila simulans results from x-linked meiotic drive. males bearing a driving x chromosome can produce a large excess of females (about 90%) in their progeny. this is, however, rarely the case in the wild, where resistance factors, including autosomal suppressors and insensitive y chromosomes, prevent the expression of the driver. in this study, we searched for drive and resistance factors in strains of drosophila simulans collected all over the world. ...	1997	28565112
cytological characterization of premeiotic versus postmeiotic defects producing hybrid male sterility among sibling species of the drosophila melanogaster complex.	in accordance with haldane's rule, hybridizations between species of the drosophila simulans clade produce fertile females but sterile males. in this study, a comprehensive characterization was undertaken on the six types of f1 males that were the result of the crosses between d. simulans, d. sechellia, and d. mauritiana. with the use of light and electron microscopy, it was shown that while each particular hybrid genotype exhibited a specific sterility phenotype, these phenotypes fell into two ...	1998	28565214
describing the evolution of reaction norm shape: body pigmentation in drosophila.	if phenotypic plasticity is a trait subject to selection and evolution, we need to quantify reaction norms and to identify the potential target(s) of selection. previously we proposed the use of polynomial coefficients as reaction norm descriptors. however, the interpretation of these coefficients is not straightforward if the reaction norm is not linear. therefore, we instead propose the use of characteristic values to describe reaction norms. we depict such characteristic values for linear, qu ...	1998	28565397
evolution of driving x chromosomes and resistance factors in experimental populations of drosophila simulans.	sex-ratio drive is a particular case of meiotic drive, described in several drosophila species, that causes males bearing driving x chromosome to produce a large excess of females in their progeny. in drosophila simulans, driving x chromosomes and resistance factors located on the y chromosome and on the autosomes have been previously reported. in this paper, we report the study of the dynamics of sex-ratio factors in experimental populations. we followed the evolution in frequency of driving x ...	1999	28565407
growth temperature and adult pigmentation in two drosophila sibling species: an adaptive convergence of reaction norms in sympatric populations?	phenotypic plasticity of abdomen pigmentation was investigated in populations of the sibling species drosophila melanogaster and d. simulans, living in sympatry in two french localities. ten isofemale lines of each population and species were grown at different constant temperatures spanning their complete thermal range from 12 to 31°c. genetic variability between isofemale lines was not affected by growth temperature, but was consistently less in d. simulans. for all traits, the dark pigmentati ...	1996	28565663
extinction due to evolution of a competitor.	when drosophila simulans and drosophila funebris were cultured together in population cages over many generations, there was a prolonged period of apparently stable coexistence followed by a rapid exclusion of d. funebris. as both species maintained large population sizes in monocultures it follows that the extinctions of d. funebris in the mixed-species cultures must have been caused by d. simulans. the time to extinction of d. funebris ranged from 26 weeks in one cage, to between 40 and 48 wee ...	1991	28567883
the genetics of an isolating mechanism between two sibling species of drosophila.	matings between drosophila simulans females and males of the sibling species d. mauritiana are of abnormally short duration. these rapid matings interrupt the transfer of sperm, leading to substantial reproductive isolation in interspecific as compared to intraspecific copulations. genetic analysis of this behavior shows that it is influenced much more by the male than the female genotype, with genes from d. simulans being dominant. in males, shortened copulation is caused by interspecific diver ...	1993	28567909
genetic distance in the sibling species drosophila melanogaster, drosophila simulans and drosophila mauritiana.		1982	28568044
resistance of the sibling species drosophila melanogaster and drosophila simulans to high temperatures in relation to humidity: evolutionary implications.		1979	28568073
dynamics of p-m hybrid dysgenesis in p-transformed lines of drosophila simulans.	an autonomous p element from drosophila melanogaster was introduced by microinjection into the germ line of its sibling species, drosophila simulans. the invasion kinetics of p elements was studied in seven independent lines over 60 generations, using gel blotting, in situ hybridization, and dysgenic crosses. some of the main phenotypic and molecular characteristics of p-m hybrid dysgenesis were observed, i.e., gonadal dysgenesis (gd sterility), chromosome rearrangements, and the occurrence of d ...	1990	28568199
a multilevel approach to the significance of genetic variation in alcohol dehydrogenase of drosophila.	prior studies showed that differences in alcohol dehydrogenase (adh) activity across genotypes of drosophila are decisive for the outcome of selection by ethanol. in the present paper, the effect on adh activity and egg-to-adult survival of combinations of ethanol, propan-2-ol, and acetone in naturally occurring concentrations is examined. propan-2-ol is converted into acetone by adh in vitro. acetone is considered a competitive inhibitor of ethanol for the adh enzymes. the melanogaster-adh-s al ...	1994	28568248
evolution of incompatibility-inducing microbes and their hosts.	in many insect species, males infected with microbes related to wolbachia pipientis are "incompatible" with uninfected females. crosses between infected males and uninfected females produce significantly fewer adult progeny than the other three possible crosses. the incompatibility-inducing microbes are usually maternally transmitted. thus, incompatibility tends to confer a reproductive advantage on infected females in polymorphic populations, allowing these infections to spread. this paper anal ...	1994	28568404
adaptation and specialization in a two-resource environment in drosophila species.	we assayed two components of performance (development time and survivorship), on food medium with and without ethanol, in laboratory populations of drosophila simulans and d. melanogaster for which ethanol-medium was a novel food resource. these assays were done before and after 12 generations of rearing in either one-(regular medium only) or two-resource (regular medium and ethanol medium) environments. initially, d. simulans was highly susceptible to ethanol, whereas d. melanogaster was relati ...	1997	28568582
quantitative genetic analysis of divergence in male secondary sexual traits between drosophila simulans and drosophila mauritiana.	the sibling species drosophila simulans and d. mauritiana differ significantly in a number of male secondary sexual traits, providing an ideal system for genetic analysis of interspecific morphological divergence. in the experiment reported here, f1 hybrids from a cross of two inbred lines were backcrossed in both directions and about 200 flies from each backcross were scored for several traits (bristle numbers and cuticle areas), as well as 18 markers distributed throughout the genome. each tra ...	1997	28568599
wolbachia infection in drosophila simulans: does the female host bear a physiological cost?	fitness traits of three drosophila simulans strains infected by endocellular bacteria belonging to the genus wolbachia have been compared with those of replicate stocks previously cured from the infection by an antibiotic treatment. the traits measured were development time, egg-to-adult viability, egg hatch, productivity, fecundity, and the number of functional ovarioles. individuals of the first strain were bi-infected by two wolbachia variants, wha and wno. the second strain was infected by w ...	1997	28568785
evolution of broad and specific competitive ability in novel versus familiar environments in drosophila species.	we used nine pairs of competing drosophila melanogaster and drosophila simulans populations to test three hypotheses. (1) weaker competitors undergo greater evolutionary increases in competitive ability, compared with stronger ones. (2) increased competitive ability against a specific competitor population causes a correlated increase in competitive ability against other competitor populations. (3) in a novel environment, adaptation to the abiotic environment contributes more to competitive abil ...	1996	28568885
the genetic basis of sexual isolation between drosophila melanogaster and d. simulans.	the genetic analysis of sexual isolation between the closely-related species drosophila melanogaster and drosophila simulans involved two experiments with no-choice tests. the efficiency of sexual isolation was measured by the frequency of courtship initiation and interspecific mating. we first surveyed the variation in sexual isolation between d. melanogaster strains and d. simulans strains of different geographic origin. then, to investigate variation in sexual isolation within strains, we mad ...	1992	28568993
the drosophila simulans y chromosome interacts with the autosomes to influence male fitness.	the y chromosome should degenerate because it cannot recombine. however, male-limited transmission increases selection efficiency for male-benefit alleles on the y, and therefore, y chromosomes should contribute significantly to variation in male fitness. this means that although the drosophila y chromosome is small and gene-poor, y-linked genes are vital for male fertility in drosophila melanogaster and the y chromosome has large male fitness effects. it is unclear whether the same pattern is s ...	2017	28703322
analysis of cytochrome p450 contribution to evolved plant toxin resistance in drosophila sechellia.	drosophila sechellia is a dietary specialist species of fruit fly that has evolved resistance to the toxic secondary defence compounds produced by the fruit of its preferred host plant morinda citrifolia. the genetic basis of adult toxin resistance is the result of evolution at five loci across the genome. genetic mapping between d. sechellia and drosophila simulans and subsequent functional studies in drosophila melanogaster have identified candidate genes potentially underlying one locus invol ...	2017	28703934
adaptive evolution leads to cross-species incompatibility in the pirna transposon silencing machinery.	reproductive isolation defines species divergence and is linked to adaptive evolution of hybrid incompatibility genes. hybrids between drosophila melanogaster and drosophila simulans are sterile, and phenocopy mutations in the piwi interacting rna (pirna) pathway, which silences transposons and shows pervasive adaptive evolution, and drosophila rhino and deadlock encode rapidly evolving components of a complex that binds to pirna clusters. we show that rhino and deadlock interact and co-localize ...	2017	28919205
population genomics of wolbachia and mtdna in drosophila simulans from california.	wolbachia pipientis is an intracellular endosymbiont infecting many arthropods and filarial nematodes. little is known about the short-term evolution of wolbachia or its interaction with its host. wolbachia is maternally inherited, resulting in co-inheritance of mitochondrial organelles such as mtdna. here i explore the evolution of wolbachia, and the relationship between wolbachia and mtdna, using a large inbred panel of drosophila simulans. i compare this to the only other large population gen ...	2017	29042606
the hybrid incompatibility genes lhr and hmr are required for sister chromatid detachment during anaphase but not for centromere function.	crosses between drosophila melanogaster females and drosophila simulans males produce hybrid sons that die at the larval stage. this hybrid lethality is suppressed by loss-of-function mutations in the d. melanogaster hybrid male rescue (hmr) or in the d. simulans lethal hybrid rescue (lhr) genes. previous studies have shown that hmr and lhr interact with heterochromatin proteins and suppress expression of transposable elements within d. melanogaster it also has been proposed that hmr and lhr fun ...	2017	29046402
high rate of translocation-based gene birth on the drosophila y chromosome.	the y chromosome is a unique genetic environment defined by a lack of recombination and male-limited inheritance. the drosophila y chromosome has been gradually acquiring genes from the rest of the genome, with only seven y-linked genes being gained over the past 63 million years (0.12 gene gains per million years). using a next-generation sequencing (ngs)-powered genomic scan, we show that gene transfers to the y chromosome are much more common than previously suspected: at least 25 have arisen ...	2017	29078298
male mate choice via cuticular hydrocarbon pheromones drives reproductive isolation between drosophila species.	mate discrimination is a key mechanism restricting gene flow between species. while studied extensively with respect to female mate choice, mechanisms of male mate choice between species are far less studied. thus, we have little knowledge of the relative frequency, importance, or overall contribution of male mate discrimination to reproductive isolation. in the present study, we estimated the relative contributions of male and female choice to reproductive isolation between drosophila simulans ...	2018	29098691
constitutive up-regulation of turandot genes rather than changes in acclimation ability is associated with the evolutionary adaptation to temperature fluctuations in drosophila simulans.	most research on thermal adaptation of ectotherms is based on experiments performed at constant temperatures. however, for short-lived insects daily fluctuations of temperature could be an important environmental parameter involved in evolutionary adaptation to thermal heterogeneity. in this study we investigated the mechanisms underlying evolutionary adaptation to daily fluctuating temperatures. we studied replicated selection lines of drosophila simulans evolved in a constant or a daily fluctu ...	2018	29175088
the role of species-specific sensory cues in male responses to mating rivals in drosophila melanogaster fruitflies.	complex sets of cues can be important in recognizing and responding to conspecific mating competitors and avoiding potentially costly heterospecific competitive interactions. within drosophila melanogaster, males can detect sensory inputs from conspecifics to assess the level of competition. they respond to rivals by significantly extending mating duration and gain significant fitness benefits from doing so. here, we tested the idea that the multiple sensory cues used by d. melanogaster males to ...	2017	29187965
a large panel of drosophila simulans reveals an abundance of common variants.	the rapidly expanding availability of large ngs data sets provides an opportunity to investigate population genetics at an unprecedented scale. drosophila simulans is the sister species of the model organism drosophila melanogaster, and is often presumed to share similar demographic history. however, previous population genetic and ecological work suggests very different signatures of selection and demography. here, we sequence a new panel of 170 inbred genotypes of a north american population o ...	2018	29228179