Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| zika antiviral chemotherapy: identification of drugs and promising starting points for drug discovery from an fda-approved library. | background the recent epidemics of zika virus (zikv) implicated it as the cause of serious and potentially lethal congenital conditions such microcephaly and other central nervous system defects, as well as the development of the guillain-barré syndrome in otherwise healthy patients. recent findings showed that anti-dengue antibodies are capable of amplifying zikv infection by a mechanism similar to antibody-dependent enhancement, increasing the severity of the disease. this scenario becomes pot ... | 2016 | 27909576 |
| genomic studies of envelope gene sequences from mosquito and human samples from bangkok, thailand. | dengue virus (denv) is an rna virus showing a high degree of genetic variation as a consequence of its proofreading inability. this variation plays an important role in virus evolution and pathogenesis. although levels of within-host genetic variation are similar following equilibrium, variation among different hosts is frequently different. to identify dengue quasispecies present among two hosts, we collected patient samples from six acute denv cases and two pools of aedes aegypti mosquitoes an ... | 2016 | 27917342 |
| indoor development of aedes aegypti in germany, 2016. | in spring 2016, a german traveller returning from martinique cultivated imported plant offsets in her home, and accidentally bred aedes aegypti. thirteen adult mosquito specimens submitted for identification and the traveller were tested for zika, dengue and chikungunya virus infections, with negative results. the detection of ae. aegypti by the 'mueckenatlas' project demonstrates the value of this passive surveillance scheme for potential public health threats posed by invasive mosquitoes in ge ... | 2016 | 27918261 |
| bioactivities of a new pyrrolidine alkaloid from the root barks of orixa japonica. | a new pyrrolidine alkaloid named (z)-3-(4-hydroxybenzylidene)-4-(4-hydroxyphenyl)-1-methylpyrrolidin-2-one was isolated from the ethanol extract of the root barks of orixa japonica. the structure of the new alkaloid was elucidated on the basis of nmr and ms analysis. the compound exhibited larvicidal activity against the fourth instar larvae of aedes aegypti (lc50 = 232.09 μg/ml), anopheles sinensis (lc50 = 49.91 μg/ml), and culex pipiens pallens (lc50 = 161.10 μg/ml). the new alkaloid also poss ... | 2016 | 27918451 |
| control of aedes aegypti breeding: a novel intervention for prevention and control of dengue in an endemic zone of delhi, india. | the study is based on hypothesis that whether continuous entomological surveillance of ae. aegypti and simultaneous appropriate interventions in key containers during non-transmission (december-may) months would have any impact on breeding of aedes and dengue cases during the following transmission months (june-november). the impact of the surveillance and intervention measures undertaken during non-transmission months were assessed by entomological indicators namely container index (ci), house ... | 2016 | 27918577 |
| toxicity of ar-curcumene and epi-β-bisabolol from hedychium larsenii (zingiberaceae) essential oil on malaria, chikungunya and st. louis encephalitis mosquito vectors. | mosquitoes act as vectors of key pathogens and parasites. plant essential oils have been recognized as important sources of biopesticides, which do not induce resistance and have limited toxic effects on human health and non-target organisms. in this research, we evaluated the larvicidal and oviposition deterrence activity of hedychium larsenii essential oil (eo) and its major compounds ar-curcumene and epi-β-bisabolol. both molecules showed high toxicity against early third instars of anopheles ... | 2017 | 27918946 |
| chikungunya: its history in africa and asia and its spread to new regions in 2013-2014. | chikungunya virus (chikv) is transmitted by aedes aegypti and aedes albopictus mosquitoes and causes febrile illness with severe arthralgia in humans. there are 3 circulating chikv genotypes, asia, east/central/south africa, and west africa. chikv was first reported in 1953 in tanzania, and up until the early 2000s, a few outbreaks and sporadic cases of chikv were mainly reported in africa and asia. however, from 2004 to 2005, a large epidemic spanned from kenya over to the southwestern indian o ... | 2016 | 27920169 |
| invasiveness of aedes aegypti and aedes albopictus and vectorial capacity for chikungunya virus. | in this review, we highlight biological characteristics of aedes aegypti and aedes albopictus, 2 invasive mosquito species and primary vectors of chikungunya virus (chikv), that set the tone of these species' invasiveness, vector competence, and vectorial capacity (vc). the invasiveness of both species, as well as their public health threats as vectors, is enhanced by preference for human blood. vector competence, characterized by the efficiency of an ingested arbovirus to replicate and become i ... | 2016 | 27920173 |
| perspectives and challenges in entomological risk assessment and vector control of chikungunya. | chikungunya virus (chikv) is primarily spread by the aedes aegypti and aedes albopictus mosquito vectors. because there is no licensed vaccine for chikv, identifying ways to reduce or eliminate mosquito populations is the most effective strategy to immediately halt transmission to man. strategies to assess the entomological risk and to control the vector are absolutely crucial to demolishing the rise of chikv. this review provides perspectives in entomological risk assessment and vector control, ... | 2016 | 27920174 |
| bridging the gap between experimental data and model parameterization for chikungunya virus transmission predictions. | chikungunya virus (chikv) has experienced 2 major expansion events in the last decade. the most recently emerged sublineage (ecsa-v) was shown to have increased efficiency in a historically secondary vector, aedes albopictus, leading to speculation that this was a major factor in expansion. subsequently, a number of experimental studies focused on the vector competence of chikv, as well as transmission modeling efforts. mathematical models have used these data to inform their own investigations, ... | 2016 | 27920175 |
| chikungunya in the americas: recommendations and conclusions. | discovered in 1953, chikungunya virus (chikv) circulated in africa and southeast asia, with periodic outbreaks, for many years. highly efficient transmission following a genetic mutation of the virus in 2005 caused its global spread. associated with significant morbidity, chikv creates a large public health burden, and despite various efforts, there are currently no licensed vaccines nor specific treatments. to garner a better understanding of the virus, identify gaps in knowledge, and guide the ... | 2016 | 27920183 |
| detection of wolbachia in aedes albopictus and their effects on chikungunya virus. | wolbachia-based vector control strategies have been proposed as a means to augment the currently existing measures for controlling dengue and chikungunya vectors. prior to utilizing wolbachia as a novel vector control strategy, it is crucial to understand the wolbachia-mosquito interactions. in this study, field surveys were conducted to screen for the infection status of wolbachia in field-collected aedes albopictus the effects of wolbachia in its native host toward the replication and dissemin ... | 2016 | 27920393 |
| towards green oviposition deterrents? effectiveness of syzygium lanceolatum (myrtaceae) essential oil against six mosquito vectors and impact on four aquatic biological control agents. | essential oils (eos) from plants may be alternative sources of molecules toxic against mosquito vectors of public health relevance. most of researches in this field focused on eos as larvicides or ovicides, while limited efforts focused on the exploitation of eos as oviposition deterrents. in the present study, the larvicidal and oviposition deterrent activity of syzygium lanceolatum leaf eo was evaluated against six mosquito species, anopheles stephensi, an. subpictus, aedes aegypti, ae. albopi ... | 2016 | 27921244 |
| consecutive large dengue outbreaks in taiwan in 2014-2015. | 2016 | 27924810 | |
| transcriptomic characterization and curation of candidate neuropeptides regulating reproduction in the eyestalk ganglia of the australian crayfish, cherax quadricarinatus. | the australian redclaw crayfish (cherax quadricarinatus) has recently received attention as an emerging candidate for sustainable aquaculture production in australia and worldwide. more importantly, c. quadricarinatus serves as a good model organism for the commercially important group of decapod crustaceans as it is distributed worldwide, easy to maintain in the laboratory and its reproductive cycle has been well documented. in order to better understand the key reproduction and development reg ... | 2016 | 27924858 |
| susceptibility of phytomonas serpens to calpain inhibitors in vitro: interference on the proliferation, ultrastructure, cysteine peptidase expression and interaction with the invertebrate host. | a pleiotropic response to the calpain inhibitor mdl28170 was detected in the tomato parasite phytomonas serpens. ultrastructural studies revealed that mdl28170 caused mitochondrial swelling, shortening of flagellum and disruption of trans golgi network. this effect was correlated to the inhibition in processing of cruzipain-like molecules, which presented an increase in expression paralleled by decreased proteolytic activity. concomitantly, a calcium-dependent cysteine peptidase was detected in ... | 2016 | 27925020 |
| dengue in the middle east and north africa: a systematic review. | dengue virus (denv) infection is widespread and its disease burden has increased in past decades. however, little is known about the epidemiology of dengue in the middle east and north africa (mena). | 2016 | 27926925 |
| comparative analysis of dengue and zika outbreaks reveals differences by setting and virus. | the pacific islands of micronesia have experienced several outbreaks of mosquito-borne diseases over the past decade. in outbreaks on small islands, the susceptible population is usually well defined, and there is no co-circulation of pathogens. because of this, analysing such outbreaks can be useful for understanding the transmission dynamics of the pathogens involved, and particularly so for yet understudied pathogens such as zika virus. here, we compared three outbreaks of dengue and zika vir ... | 2016 | 27926933 |
| public health interventions for aedes control in the time of zikavirus- a meta-review on effectiveness of vector control strategies. | there is renewed interest in effective measures to control zika and dengue vectors. a synthesis of published literature with a focus on the quality of evidence is warranted to determine the effectiveness of vector control strategies. | 2016 | 27926934 |
| optomotor reactions reveal polarization sensitvity in the zika virus transmitting yellow fever mosquito aedes (stegomyia) aegypti (diptera; nematocera). | in polarization-sensitive insect species an orthogonal arrangement of photoreceptive microvilli is a characteristic feature. however, mosquito eyes had not revealed this feature, and polarization sensitivity (ps) was considered to be non-existent in them. recently, however, gravid aedes (stegomyia) aegypti females were found to possess ps, sequels of which could be demonstrated only in the absence of chemicals emitted by conspecifics. therefore, ps in ae. aegypti, unlike that of other aquatic in ... | 2016 | 27927093 |
| aphids transform and detoxify the mycotoxin deoxynivalenol via a type ii biotransformation mechanism yet unknown in animals. | biotransformation of mycotoxins in animals comprises phase i and phase ii metabolisation reactions. for the trichothecene deoxynivalenol (don), several phase ii biotransformation reactions have been described resulting in don-glutathiones, don-glucuronides and don-sulfates made by glutathione-s-transferases, uridine-diphosphoglucuronyl transferases and sulfotransferases, respectively. these metabolites can be easily excreted and are less toxic than their free compounds. here, we demonstrate for ... | 2016 | 27929076 |
| the self-regulation model of illness: comparison between zika and dengue and its application to predict mosquito prevention behaviours in malaysia, a dengue-endemic country. | perceptions about illnesses may influence self-care and preventive health behaviours. illness perceptions of the zika virus (zikv) infection were investigated under the framework of the self-regulation model of illness. illness perception differences between zikv and dengue fever were also examined. lastly, associations between illness perceptions of zikv with mosquito prevention practices were studied. samples were drawn from landline telephone numbers using computer-assisted telephone intervie ... | 2016 | 27929451 |
| a historic report of zika in mozambique: implications for assessing current risk. | 2016 | 27930650 | |
| contraceptive sales in the setting of the zika virus epidemic. | has there been any influence of the zika virus (zikv) outbreak on the sales of contraceptive methods in brazil? | 2016 | 27932442 |
| small rnas from bemisia tabaci are transferred to solanum lycopersicum phloem during feeding. | the phloem-feeding whitefly bemisia tabaci is a serious pest to a broad range of host plants, including many economically important crops such as tomato. these insects serve as a vector for various devastating plant viruses. it is known that whiteflies are capable of manipulating host-defense responses, potentially mediated by effector molecules in the whitefly saliva. we hypothesized that, beside putative effector proteins, small rnas (srna) are delivered by b. tabaci into the phloem, where the ... | 2016 | 27933079 |
| the worldwide spread of the tiger mosquito as revealed by mitogenome haplogroup diversity. | in the last 40 years, the asian tiger mosquito aedes albopictus, indigenous to east asia, has colonized every continent except antarctica. its spread is a major public health concern, given that this species is a competent vector for numerous arboviruses, including those causing dengue, chikungunya, west nile, and the recently emerged zika fever. to acquire more information on the ancestral source(s) of adventive populations and the overall diffusion process from its native range, we analyzed th ... | 2016 | 27933090 |
| chemical composition, antimicrobial and insecticidal activities of flowers essential oils of alpinia zerumbet (pers.) b.l.burtt & r.m.sm. from martinique island. | alpinia species, used as ornamental plants and flavoring agents, are renowned for their therapeutic properties and their subsequent use in traditional medicines throughout the world. alpinia zerumbet (pers.) b.l.burtt & r.m.sm. is the most common alpinia species encountered in martinique. several essential oils (eos) obtained by hydrodistillation of a. zerumbet flowers collected in various locations on the island at different seasons were analysed to evaluate the influence of the collection peri ... | 2016 | 27935668 |
| flavivirus transmission focusing on zika. | flaviviruses are among the most diverse viruses with over 85 species recognized. taxonomically, this genus is one of the 4 recognized genera within the family flaviviridae. most flaviviruses of human public health significance, for example, dengue, yellow fever and zika viruses, are arthropod-borne (arboviruses) and have two evolutionarily and ecologically distinct transmission cycles: a sylvatic transmission cycle, where the virus circulates between zoonotic vertebrate reservoir and amplificati ... | 2017 | 27936448 |
| effect of the saliva from different triatomine species on the biology and immunity of tlr-4 ligand and trypanosoma cruzi-stimulated dendritic cells. | triatomines are blood-sucking vectors of trypanosoma cruzi, the causative agent of chagas disease. during feeding, triatomines surpass the skin host response through biomolecules present in their saliva. dendritic cells (dcs) play a crucial role in the induction of the protection to aggressive agents, including blood-sucking arthropods. here, we evaluated if salivary components of triatomines from different genera evade the host immunity by modulating the biology and the function of lps- or t. c ... | 2016 | 27938380 |
| zika virus in asia. | zika virus (zikv) is an emerging mosquito-borne virus that was first isolated from a sentinel rhesus monkey in the zika forest in uganda in 1947. in asia, the virus was isolated in malaysia from aedes aegypti mosquitoes in 1966, and the first human infections were reported in 1977 in central java, indonesia. in this review, all reported cases of zikv infection in asia as of september 1, 2016 are summarized and some of the hypotheses that could currently explain the apparently low incidence of zi ... | 2017 | 27939768 |
| impact of terminalia chebula retz. against aedes aegypti l. and non-target aquatic predatory insects. | aedes aegypti linn is one of the most important mosquito species. the vectors are responsible for causing deadly diseases like dengue and dengue hemorrhagic fever. several chemical pesticides used to control these dengue vectors caused severe toxic significances on human health and other non-target beneficial insects. therefore the current investigation has been made to access the bio-efficacy of the crude seed extracts of t. chebula against the dengue vector ae. aegypti. the gc-ms analysis of c ... | 2017 | 27940415 |
| climate variation drives dengue dynamics. | dengue, a viral infection transmitted between people by mosquitoes, is one of the most rapidly spreading diseases in the world. here, we report the analyses covering 11 y (2005-2015) from the city of guangzhou in southern china. using the first 8 y of data to develop an ecologically based model for the dengue system, we reliably predict the following 3 y of dengue dynamics-years with exceptionally extensive dengue outbreaks. we demonstrate that climate conditions, through the effects of rainfall ... | 2016 | 27940911 |
| how do households respond to unreliable water supplies? a systematic review. | although the millennium development goal (mdg) target for drinking water was met, in many developing countries water supplies are unreliable. this paper reviews how households in developing countries cope with unreliable water supplies, including coping costs, the distribution of coping costs across socio-economic groups, and effectiveness of coping strategies in meeting household water needs. structured searches were conducted in peer-reviewed and grey literature in electronic databases and sea ... | 2016 | 27941695 |
| diversity of cultivable midgut microbiota at different stages of the asian tiger mosquito, aedes albopictus from tezpur, india. | aedes aegypti and ae. albopictus are among the most important vectors of arboviral diseases, worldwide. recent studies indicate that diverse midgut microbiota of mosquitoes significantly affect development, digestion, metabolism, and immunity of their hosts. midgut microbiota has also been suggested to modulate the competency of mosquitoes to transmit arboviruses, malaria parasites etc. interestingly, the midgut microbial flora is dynamic and the diversity changes with the development of vectors ... | 2016 | 27941985 |
| long-lasting permethrin-impregnated clothing: protective efficacy against malaria in hyperendemic foci, and laundering, wearing, and weathering effects on residual bioactivity after worst-case use in the rain forests of french guiana. | personal protective measures against hematophagous vectors constitute the first line of defense against arthropod-borne diseases. however, guidelines for the standardized testing and licensing of insecticide-treated clothing are still lacking. the aim of this study was to analyze the preventive effect of long-lasting polymer-coated permethrin-impregnated clothing (ptbdu) against malaria after exposure to high-level disease transmission sites as well as the corresponding loss of permethrin and bi ... | 2017 | 27942961 |
| cardiovascular effects of the essential oil of croton argyrophylloides in normotensive rats: role of the autonomic nervous system. | cardiovascular effects of the essential oil of croton argyrophylloides muell. arg. (eoca) were investigated in normotensive rats. in saline-pretreated anesthetized or conscious rats, intravenous (i.v.) injection of the eoca induced dose-dependent hypotension. dose-dependent tachycardia was observed only in conscious rats. in anesthetized rats, cervical bivagotomy failed to enhance eoca-induced hypotension but unmasked significant bradycardia. in conscious rats, i.v. pretreatment with methylatrop ... | 2016 | 27956919 |
| mitigating the risk of transfusion-transmitted dengue in australia. | dengue viruses (denv 1-4) are a risk to transfusion safety, with several transfusion-transmitted (tt) cases reported globally. denv 1-4 are endemic in over 100 countries, with seasonal outbreaks occurring in northeastern australia. to mitigate tt-denv risk in australia, fresh blood components are not manufactured from donors returning from any area (domestic/overseas) with known dengue transmission. alternatively, tt-denv risk may be mitigated using an appropriate blood donor screening assay. we ... | 2016 | 27957384 |
| perspectives on the role of mobility, behavior, and time scales in the spread of diseases. | the dynamics, control, and evolution of communicable and vector-borne diseases are intimately connected to the joint dynamics of epidemiological, behavioral, and mobility processes that operate across multiple spatial, temporal, and organizational scales. the identification of a theoretical explanatory framework that accounts for the pattern regularity exhibited by a large number of host-parasite systems, including those sustained by host-vector epidemiological dynamics, is but one of the challe ... | 2016 | 27965394 |
| annotation of the asian citrus psyllid genome reveals a reduced innate immune system. | citrus production worldwide is currently facing significant losses due to citrus greening disease, also known as huanglongbing. the citrus greening bacteria, candidatus liberibacter asiaticus (clas), is a persistent propagative pathogen transmitted by the asian citrus psyllid, diaphorina citri kuwayama (hemiptera: liviidae). hemipterans characterized to date lack a number of insect immune genes, including those associated with the imd pathway targeting gram-negative bacteria. the d. citri draft ... | 2016 | 27965582 |
| oviposition habitat selection of dengue vectors, aedes aegypti and aedes albopictus in response to fish predator. | to understand the effects of fish predator's kairomones on aedes mosquitoes' oviposition, we established an experiment using gravid aedes females. kairomones concentrations were established using hampala macrolepidota. one individual fish was placed inside containers with varying water levels (1 l, 5 l, and 10 l of water). the fish were kept in the containers for 24 hours and were removed immediately at the start of each trial in order to have the kairomones remnants. twenty gravid adult females ... | 0 | 27965749 |
| identification of development-related genes in the ovaries of adult harmonia axyridis (pallas) lady beetles using a time- series analysis by rna-seq. | adults of the lady beetle species harmonia axyridis (pallas) are bred artificially en masse for classic biological control, which requires egg-laying by the h. axyridis ovary. development-related genes may impact the growth of the h. axyridis adult ovary but have not been reported. here, we used integrative time-series rna-seq analysis of the ovary in h. axyridis adults to detect development-related genes. a total of 28,558 unigenes were functionally annotated using seven types of databases to o ... | 2016 | 27966611 |
| the influence of urbanization modes on the spatial circulation of flaviviruses within ouagadougou (burkina faso). | dengue is an emerging infectious disease of global significance. although this virus has been reported for a long time, its significance within the burden of diseases in west africa is not obvious, especially in burkina faso. our objective was to evaluate flavivirus presence in ouagadougou (burkina faso) and the link between anti-flavivirus antibody seroprevalence and urbanization modes. a population-based cross-sectional survey was conducted and 3015 children were enrolled from ouagadougou dist ... | 2016 | 27973402 |
| variations on a theme: antennal lobe architecture across coleoptera. | beetles comprise about 400,000 described species, nearly one third of all known animal species. the enormous success of the order coleoptera is reflected by a rich diversity of lifestyles, behaviors, morphological, and physiological adaptions. all these evolutionary adaptions that have been driven by a variety of parameters over the last about 300 million years, make the coleoptera an ideal field to study the evolution of the brain on the interface between the basic bauplan of the insect brain a ... | 2016 | 27973569 |
| effect of heavy-equipment aided environmental nebulization on aedes aegypti vectors of dengue, zika and chikungunya in são paulo, brazil. | the control of dengue constitutes a great challenge for public health; however, the methods normally used have shown themselves to be insufficient to keep the indices of infestation of aedes aegypti under control. recently, beyond the large number of cases and deaths associated with dengue, new risks have arisen such as those represented by chikungunya fever and zika. in the light of the great significance of these problems within the public health context, two areas in a municipality in the int ... | 2016 | 27974058 |
| rplp1 and rplp2 are essential flavivirus host factors that promote early viral protein accumulation. | the flavivirus genus contains several arthropod-borne viruses that pose global health threats, including dengue viruses (denv), yellow fever virus (yfv), and zika virus (zikv). in order to understand how these viruses replicate in human cells, we previously conducted genome-scale rna interference screens to identify candidate host factors. in these screens, we identified ribosomal proteins rplp1 and rplp2 (rplp1/2) to be among the most crucial putative host factors required for denv and yfv infe ... | 2017 | 27974556 |
| potential for zika virus to establish a sylvatic transmission cycle in the americas. | zika virus (zikv) originated and continues to circulate in a sylvatic transmission cycle between non-human primate hosts and arboreal mosquitoes in tropical africa. recently zikv invaded the americas, where it poses a threat to human health, especially to pregnant women and their infants. here we examine the risk that zikv will establish a sylvatic cycle in the americas, focusing on brazil. we review the natural history of sylvatic zikv and present a mathematical dynamic transmission model to as ... | 2016 | 27977671 |
| declining prevalence of disease vectors under climate change. | more than half of the world population is at risk of vector-borne diseases including dengue fever, chikungunya, zika, yellow fever, leishmaniasis, chagas disease, and malaria, with highest incidences in tropical regions. in ecuador, vector-borne diseases are present from coastal and amazonian regions to the andes mountains; however, a detailed characterization of the distribution of their vectors has never been carried out. we estimate the distribution of 14 vectors of the above vector-borne dis ... | 2016 | 27982119 |
| detection of human anti-zika virus igg by elisa using an antigen from in vitro infected vero cells: preliminary results. | zika virus (zkv) infection is a huge public health problem in brazil because of the increased incidence of microcephaly in neonates from infected mothers. detection of specific igg antibodies in maternal serum samples constitutes an important approach for diagnosing zkv infection and evaluating its relationship with neonatal microcephaly. however, as there is no serological test produced in brazil to detect igm and igg antibodies against zkv, we sought to examine specific igg in serum samples fr ... | 2016 | 27982355 |
| chikungunya fever in traveler from angola to japan, 2016. | simultaneous circulation of multiple arboviruses presents diagnostic challenges. in may 2016, chikungunya fever was diagnosed in a traveler from angola to japan. travel history, incubation period, and phylogenetic analysis indicated probable infection acquisition in angola, where a yellow fever outbreak is ongoing. thus, local transmission of chikungunya virus probably also occurs in angola. | 0 | 27983938 |
| diverse subcellular localizations of the insect cmp-sialic acid synthetases. | the occurrence and biological importance of sialic acid (sia) and its metabolic enzymes in insects have been studied using drosophila melanogaster. the most prominent feature of d. melanogaster cmp-sia synthetase (dmcss) is its golgi-localization, contrasted with nuclear localization of vertebrate csss. however, it remains unclear if the golgi-localization is common to other insect csss and why it happens. to answer these questions, aedes aegypti (mosquito) css (aacss) and tribolium castaneum (b ... | 2017 | 27986833 |
| salinity alters snakeskin and mesh transcript abundance and permeability in midgut and malpighian tubules of larval mosquito, aedes aegypti. | this study examined the distribution and localization of the septate junction (sj) proteins snakeskin (ssk) and mesh in osmoregulatory organs of larval mosquito (aedes aegypti), as well as their response to altered environmental salt levels. ssk and mesh transcripts and immunoreactivity were detected in tissues of endodermal origin such as the midgut and malpighian tubules of a. aegypti larvae, but not in ectodermally derived hindgut and anal papillae. immunolocalization of ssk and mesh in the m ... | 2017 | 27988380 |
| zika in america: the year in review. | short on funds and with no therapeutics or vaccines in sight, u.s. health officials are scrambling to prepare for a protracted fight with zika virus and the mosquitoes that carry it. in this article, the author focuses on the arrival of zika in the u.s. | 0 | 27990081 |
| travel volume to the united states from countries and u.s. territories with local zika virus transmission. | air, land, and sea transportation can facilitate rapid spread of infectious diseases. in may 2015 the pan american health organization (paho) issued an alert regarding the first confirmed zika virus infection in brazil. as of march 8, 2016, the u.s. centers for disease control and prevention (cdc) had issued travel notices for 33 countries and 3 u.s. territories with local zika virus transmission. | 2016 | 27990321 |
| attempts to image the early inflammatory response during infection with the lymphatic filarial nematode brugia pahangi in a mouse model. | helminth parasites remain a major constraint upon human health and well-being in many parts of the world. treatment of these infections relies upon a very small number of therapeutics, most of which were originally developed for use in animal health. a lack of high throughput screening systems, together with limitations of available animal models, has restricted the development of novel chemotherapeutics. this is particularly so for filarial nematodes, which are long-lived parasites with a compl ... | 2016 | 27992545 |
| papular urticaria: a review of causal agents in colombia. | papular urticaria is a chronic allergic reaction induced by insect bites, which is common in the tropics. the objective of this review was to deepen on epidemiological and immunological aspects of this disease, focused on data published in latin american countries.we conducted a non-systematic review of the literature through electronic search on the epidemiology of papular urticaria, the entomological characteristics of the causative agents and associated immunological mechanisms.several report ... | 2016 | 27992990 |
| global risk model for vector-borne transmission of zika virus reveals the role of el niño 2015. | zika, a mosquito-borne viral disease that emerged in south america in 2015, was declared a public health emergency of international concern by the who in february of 2016. we developed a climate-driven r0 mathematical model for the transmission risk of zika virus (zikv) that explicitly includes two key mosquito vector species: aedes aegypti and aedes albopictus the model was parameterized and calibrated using the most up to date information from the available literature. it was then driven by ob ... | 2016 | 27994145 |
| zika virus (zikv). | 2016 | 27994533 | |
| beyond traditional antimicrobials: a caenorhabditis elegans model for discovery of novel anti-infectives. | the spread of antibiotic resistance amongst bacterial pathogens has led to an urgent need for new antimicrobial compounds with novel modes of action that minimize the potential for drug resistance. to date, the development of new antimicrobial drugs is still lagging far behind the rising demand, partly owing to the absence of an effective screening platform. over the last decade, the nematode caenorhabditis elegans has been incorporated as a whole animal screening platform for antimicrobials. th ... | 2016 | 27994583 |
| rna interference as a gene silencing tool to control tuta absoluta in tomato (solanum lycopersicum). | rna interference (rnai), a gene-silencing mechanism that involves providing double-stranded rna molecules that match a specific target gene sequence, is now widely used in functional genetic studies. the potential application of rnai-mediated control of agricultural insect pests has rapidly become evident. the production of transgenic plants expressing dsrna molecules that target essential insect genes could provide a means of specific gene silencing in larvae that feed on these plants, resultin ... | 2016 | 27994959 |
| exotic mosquito threats require strategic surveillance and response planning. | mosquito-borne diseases caused by endemic pathogens such as ross river, barmah forest and murray valley encephalitis viruses are an annual concern in new south wales (nsw), australia. more than a dozen mosquito species have been implicated in the transmission of these pathogens, with each mosquito occupying a specialised ecological niche that influences their habitat associations, host feeding preferences and the environmental drivers of their abundance. the nsw arbovirus surveillance and mosqui ... | 2016 | 27997935 |
| the effect of west nile virus infection on the midgut gene expression of culex pipiens quinquefasciatus say (diptera: culicidae). | the interaction of the mosquito and the invading virus is complex and can result in physiological and gene expression alterations in the insect. the association of west nile virus (wnv) and culex pipiens quinquefasciatus mosquitoes results in measurable changes in gene expression; 22 gene products were shown previously to have altered expression. sequence analysis of one product, cq g1a1, revealed 100% amino acid identity to gram negative bacteria binding proteins (cpqgbp) in cx. p. quinquefasci ... | 2016 | 27999244 |
| spatiotemporal frameworks for infectious disease diffusion and epidemiology. | emerging infectious diseases, and the resurgence of previously controlled infectious disease (e.g., malaria, tuberculosis), are a major focus for public health concern, as well as providing challenges for establishing aetiology and transmission. [...]. | 2016 | 27999420 |
| a biodegradable device for the controlled release of piper nigrum (piperaceae) standardized extract to control aedes aegypti (diptera, culicidae) larvae. | the significant increase in dengue, zika, and chikungunya and the resistance of the aedes aegypti mosquito to major insecticides emphasize the importance of studying alternatives to control this vector. the aim of this study was to develop a controlled-release device containing piper nigrum extract and to study its larvicidal activity against aedes aegypti. | 2017 | 28001214 |
| in vitro evaluation of the effect of botanical formulations used in the control of aedes aegypti l. (diptera: culicidae) on liver enzymes. | dengue fever is a viral disease transmitted by the aedes aegypti linn. (1792) (diptera: culicidae) mosquito, which is endemic in several regions of brazil. alternative methods for the control of the vector include botanical insecticides, which offer advantages such as lower environmental contamination levels and less likelihood of resistant populations. thus, in this study, the ability of botanical insecticide formulations to inhibit the activity of the liver enzymes serum cholinesterase and mal ... | 2017 | 28001215 |
| restriction to gene flow is associated with changes in the molecular basis of pyrethroid resistance in the malaria vector anopheles funestus. | resistance to pyrethroids, the sole insecticide class recommended for treating bed nets, threatens the control of major malaria vectors, including anopheles funestus effective management of resistance requires an understanding of the dynamics and mechanisms driving resistance. here, using genome-wide transcription and genetic diversity analyses, we show that a shift in the molecular basis of pyrethroid resistance in southern african populations of this species is associated with a restricted gen ... | 2016 | 28003461 |
| zika virus vector competency of mosquitoes, gulf coast, united states. | zika virus has recently spread throughout the americas. although aedes aegypti mosquitoes are considered the primary vector, culex quinquefasciatus and mosquitoes of other species may also be vectors. we tested cx. quinquefasciatus and ae. taeniorhynchus mosquitoes from the us gulf coast; both were refractory to infection and incapable of transmission. | 2017 | 28005002 |
| functional evolution of a morphogenetic gradient. | bone morphogenetic proteins (bmps) pattern the dorsal-ventral axis of bilaterian embryos; however, their roles in the evolution of body plan are largely unknown. we examined their functional evolution in fly embryos. bmp signaling specifies two extraembryonic tissues, the serosa and amnion, in basal-branching flies such as megaselia abdita, but only one, the amnioserosa, in drosophila melanogaster. the bmp signaling dynamics are similar in both species until the beginning of gastrulation, when b ... | 2016 | 28005004 |
| animals in the zika virus life cycle: what to expect from megadiverse latin american countries. | zika virus (zikv) was first isolated in 1947 in primates in uganda, west africa. the virus remained confined to the equatorial regions of africa and asia, cycling between infecting monkeys, arboreal mosquitoes, and occasionally humans. the zikv asiatic strain was probably introduced into brazil in or around late 2013. presently, zikv is in contact with the rich biodiversity in all brazilian biomes, bordering on other latin american countries. infections in brazilian primates have been reported r ... | 2016 | 28005902 |
| exon-enriched libraries reveal large genic differences between aedes aegypti from senegal, west africa, and populations outside africa. | aedes aegypti is one of the most studied mosquito species, and the principal vector of several arboviruses pathogenic to humans. recently failure to oviposit, low fecundity, and poor egg-to-adult survival were observed when ae. aegypti from senegal (senaae) west africa were crossed with ae. aegypti (aaa) from outside of africa, and in senaae intercrosses. fluorescent in situ hybridization analyses indicated rearrangements on chromosome 1, and pericentric inversions on chromosomes 2 and 3. herein ... | 2017 | 28007834 |
| artificial diets for mosquitoes. | mosquito-borne diseases are responsible for more than a million human deaths every year. modern mosquito control strategies such as sterile insect technique (sit), release of insects carrying a dominant lethal (ridl), population replacement strategies (pr), and wolbachia-based strategies require the rearing of large numbers of mosquitoes in culture for continuous release over an extended period of time. anautogenous mosquitoes require essential nutrients for egg production, which they obtain thr ... | 2016 | 28009851 |
| toxicity and synergistic activities of chalcones against aedes aegypti (diptera: culicidae) and drosophila melanogaster (diptera: drosophilidae). | mosquito-borne illnesses are of great concern throughout the world, and chemical insecticides are commonly employed to decrease mosquito populations. however, the developmental insecticide pipeline for vector control has primarily been filled by repurposed agricultural products, and is hampered by their widespread use and insecticide resistance. the present study was performed in the search for new chemical insecticides or insecticide synergists. screening of 31 chalcone analogs was performed us ... | 2017 | 28011724 |
| indoor resting behavior of aedes aegypti (diptera: culicidae) in acapulco, mexico. | the markedly anthropophilic and endophilic behaviors of aedes aegypti (l.) make it a very efficient vector of dengue, chikungunya, and zika viruses. although a large body of research has investigated the immature habitats and conditions for adult emergence, relatively few studies have focused on the indoor resting behavior and distribution of vectors within houses. we investigated the resting behavior of ae. aegypti indoors in 979 houses of the city of acapulco, mexico, by performing exhaustive ... | 2017 | 28011725 |
| influence of the length of storage on aedes aegypti (diptera: culicidae) egg viability. | aedes aegypti (l.) is one of the most important arboviral vectors worldwide. vector control is targeted at immature and adult stages; however, eggs are resistant to desiccation and may repopulate treated areas long after treatment ceases. we investigated the effect of age on ae. aegypti egg hatching rates using newly colonized populations (f2) from an arid region. we found a strongly negative association where older eggs had lower hatch rates. the capacity of eggs to survive for long periods of ... | 2017 | 28011737 |
| mosquito repellent activity of volatile oils from selected aromatic plants. | essential oils from fresh leaves of four aromatic plants viz., ocimum sanctum, mentha piperita, eucalyptus globulus and plectranthus amboinicus were extracted by hydrodistillation. the test solutions were prepared as 20% essential oil in ethanol and positive control as 20% deet in ethanol. essential oil blend was prepared as 5% concentration. nulliparous, 3-5-day-old female adult aedes aegypti mosquitoes were used for repellency screening as per icmr protocol. the study showed that the repellenc ... | 2017 | 28013374 |
| n-glycosylation influences the catalytic activity of mosquito α-glucosidases associated with susceptibility or refractoriness to lysinibacillus sphaericus. | cqm1 and aam1 are α-glucosidases (ec 3.2.1.20) expressed in culex quinquefasciatus and aedes aegypti larvae midgut, respectively. these orthologs share high sequence similarity but while cqm1 acts as a receptor for the binary (bin) insecticidal toxin from lysinibacillus sphaericus, aam1 does not bind the toxin, rendering ae. aegypti refractory to this bacterium. aam1 is heavily glycosylated, contrasting to cqm1, but little is known regarding how glycosylation impacts on its function. this study ... | 2017 | 28017798 |
| detection and perception of generic host volatiles by mosquitoes modulate host preference: context dependence of (r)-1-octen-3-ol. | natural selection favours a restricted host breadth in disease vector mosquitoes, indicating that there is an adaptive value associated with maintaining plasticity in host preference. one mechanism to maintain such plasticity is via the detection of generic cues by conserved peripheral olfactory pathways, which when perceived in different host odour contexts enable the identification of and discrimination among potential host species. here, we show that the context of an odour cue shapes host pe ... | 2016 | 28018630 |
| expression of heat shock proteins (hsps) in aedes aegypti (l) and aedes albopictus (skuse) (diptera: culicidae) larvae in response to thermal stress. | climatic changes are responsible, to a certain extent for the occurrence and spread of arboviral pathogens world over. temperature is one of the important abiotic factors influencing the physiological processes of mosquitoes. several genes of heat shock protein (hsp) families are known to be expressed in mosquitoes, which aid in overcoming stress induced by elevated temperature. in order to understand expression of hsp family genes in the andaman population of aedes aegypti and aedes albopictus, ... | 2017 | 28024869 |
| imitedb: the genome-wide landscape of miniature inverted-repeat transposable elements in insects. | miniature inverted-repeat transposable elements (mites) have attracted much attention due to their widespread occurrence and high copy numbers in eukaryotic genomes. however, the systematic knowledge about mites in insects and other animals is still lacking. in this study, we identified 6012 mite families from 98 insect species genomes. comparison of these mites with known mites in the ncbi non-redundant database and repbase showed that 5701(∼95%) of 6012 mite families are novel. the abundance o ... | 2016 | 28025339 |
| toxicity and physiological actions of carbonic anhydrase inhibitors to aedes aegypti and drosophila melanogaster. | the physiological role of carbonic anhydrases in ph and ion regulation is crucial to insect survival. we examined the toxic and neurophysiological effects of five carbonic anhydrase inhibitors (cais) against aedes aegypti. the 24 h larvicidal toxicities followed this rank order of potency: dichlorphenamide > methazolamide > acetazolamide = brinzolamide = dorzolamide. larvicidal activity increased modestly in longer exposures, and affected larvae showed attenuated responses to probing without ove ... | 2016 | 28025488 |
| clinical profiles of dengue infection during an outbreak in northern india. | introduction. dengue fever is an arboviral disease, which is transmitted by mosquito vector and presents as varied clinical spectrum of dengue fever (df), dengue hemorrhagic fever (dhf), dengue shock syndrome (dss), and expanded dengue syndrome (eds) with atypical presentations, thus posing a diagnostic dilemma. unless we are aware of these presentations, diagnosis as well as early initiation of treatment becomes difficult. we studied the various clinical presentations of dengue infection during ... | 2016 | 28025597 |
| scavenger receptor c mediates phagocytosis of white spot syndrome virus and restricts virus proliferation in shrimp. | scavenger receptors are an important class of pattern recognition receptors that play several important roles in host defense against pathogens. the class c scavenger receptors (srcs) have only been identified in a few invertebrates, and their role in the immune response against viruses is seldom studied. in this study, we firstly identified an src from kuruma shrimp, marsupenaeus japonicus, designated mjsrc, which was significantly upregulated after white spot syndrome virus (wssv) challenge at ... | 2016 | 28027319 |
| molecular virologic and clinical characteristics of a chikungunya fever outbreak in la romana, dominican republic, 2014. | since emerging in saint martin in 2013, chikungunya virus (chikv), an alphavirus transmitted by the aedes aegypti mosquito, has infected approximately two million individuals in the americas, with over 500,000 reported cases in the dominican republic (dr). chikv-infected patients typically present with a febrile syndrome including polyarthritis/polyarthralgia, and a macropapular rash, similar to those infected with dengue and zika viruses, and malaria. nevertheless, many dominican cases are unco ... | 2016 | 28030537 |
| impact of autocidal gravid ovitraps on chikungunya virus incidence in aedes aegypti (diptera: culicidae) in areas with and without traps. | puerto rico detected the first confirmed case of chikungunya virus (chikv) in may 2014 and the virus rapidly spread throughout the island. the invasion of chikv allowed us to observe aedes aegypti (l.) densities, infection rates, and impact of vector control in urban areas using cdc autocidal gravid ovitraps (ago traps) for mosquito control over several years. because local mosquitoes can only get the virus from infectious residents, detecting the presence of virus in mosquitoes functions as a p ... | 2016 | 28031347 |
| economic report on the cost of dengue fever in vietnam: case of a provincial hospital. | dengue is a mosquito-borne viral illness with the world's fastest rate of infection. in 2014, vietnam had recorded 43,000 cases in 53 provinces, with 28 deaths. | 2016 | 28031723 |
| retrospective analysis of prognostic factors in dengue infected patients with intracranial bleed. | dengue is one of the most common mosquito-transmitted arboviral disease of tropical and a few subtropical areas in the world. it is estimated that approximately 100 million cases occur per year and approximately 2.5 billion people are at risk of developing dengue infection. hemorrhagic complications causing encephalopathy are quite rare but fatal consequences of this deadly disease. this study was conducted to discuss the prognostic factors in the management of intracranial hemorrhage in dengue ... | 2016 | 28031986 |
| laboratory evaluation of temephos against anopheles stephensi and culex pipiens larvae in iran. | malaria is still a health problem in iran. there are several vector control activities, including indoor residual spraying, using insecticide treated nets and larviciding including temephos. in addition nuisance mosquitos are prevalent in the urban areas. so that evaluation of this species to larvicide will provide a clue for management of vector control activities. | 2016 | 28032103 |
| genetic analysis of aedes aegypti using random amplified polymorphic dna (rapd) markers from dengue outbreaks in pakistan. | keeping in view the havoc situation of dengue fever in pakistan, the current study was designed to demonstrate the genetic variations, gene flow and rate of migration from lahore and faisalabad. | 2016 | 28032107 |
| vorticella sp: prospective mosquito biocontrol agent. | considering the disadvantages of chemical insecticides, we aimed to evaluate vorticella parasites for control of mosquito larvae of anopheles stephensi and aedes aegypti at different larval stages. | 2016 | 28032113 |
| piwis go viral: arbovirus-derived pirnas in vector mosquitoes. | vector mosquitoes are responsible for transmission of the majority of arthropod-borne (arbo-) viruses. virus replication in these vectors needs to be sufficiently high to permit efficient virus transfer to vertebrate hosts. the mosquito immune response therefore is a key determinant for arbovirus transmission. mosquito antiviral immunity is primarily mediated by the small interfering rna pathway. besides this well-established antiviral machinery, the piwi-interacting rna (pirna) pathway processe ... | 2016 | 28033427 |
| gc content heterogeneity transition of conserved noncoding sequences occurred at the emergence of vertebrates. | conserved non-coding sequences (cnss) of eukaryotes are known to be significantly enriched in regulatory sequences. cnss of diverse lineages follow different patterns in abundance, sequence composition, and location. here, we report a thorough analysis of cnss in diverse groups of eukaryotes with respect to gc content heterogeneity. we examined 24 fungi, 19 invertebrates, and 12 non-mammalian vertebrates so as to find lineage specific features of cnss. we found that fungi and invertebrate cnss a ... | 2016 | 28040773 |
| oral delivery of dsrna by microbes: beyond pest control. | rna interference (rnai) by oral delivery of dsrna in insects has great potential as a tool for integrated pest management (ipm), especially with respect to addressing the need to reduce off-target effect and slow down resistance development to chemical insecticides. employing the natural association existing between insect and yeast, we developed a novel method to enable the knock down of vital genes in the pest insect drosophila suzukii through oral delivery of species-specific dsrna using gene ... | 2016 | 28042376 |
| artesunate-tafenoquine combination therapy promotes clearance and abrogates transmission of the avian malaria parasite plasmodium gallinaceum. | clinical manifestations of malaria infection in vertebrate hosts arise from the multiplication of the asexual stage parasites in the blood, while the gametocytes are responsible for the transmission of the disease. antimalarial drugs that target the blood stage parasites and transmissible gametocytes are rare, but are essentially needed for the effective control of malaria and for limiting the spread of resistance. artemisinin and its derivatives are the current first-line antimalarials that are ... | 2017 | 28043395 |
| the transcriptome of the mosquito aedes fluviatilis (diptera: culicidae), and transcriptional changes associated with its native wolbachia infection. | wolbachia is a bacterial endosymbiont that naturally infects a wide range of insect species, and causes drastic changes to host biology. stable infections of wolbachia in mosquitoes can inhibit infection with medically important pathogens such as dengue virus and malaria-causing plasmodium parasites. however, some native wolbachia strains can enhance infection with certain pathogens, as is the case for the mosquito aedes fluviatilis, where infection with plasmodium gallinaceum is enhanced by the ... | 2017 | 28049478 |
| pterodon emarginatus oleoresin-based nanoemulsion as a promising tool for culex quinquefasciatus (diptera: culicidae) control. | preparation of nanoformulations using natural products as bioactive substances is considered very promising for innovative larvicidal agents. on this context, oil in water nanoemulsions develop a main role, since they satisfactorily disperse poor-water soluble substances, such as herbal oils, in aqueous media. pterodon emarginatus, popularly known as sucupira, has a promising bioactive oleoresin. however, to our knowledge, no previous studies were carried out to evaluate its potential against cu ... | 2017 | 28049483 |
| the dangers of accepting a single diagnosis: case report of concurrent plasmodium knowlesi malaria and dengue infection. | dengue and malaria are two common, mosquito-borne infections, which may lead to mortality if not managed properly. concurrent infections of dengue and malaria are rare due to the different habitats of its vectors and activities of different carrier mosquitoes. the first case reported was in 2005. since then, several concurrent infections have been reported between the dengue virus (denv) and the malaria protozoans, plasmodium falciparum and plasmodium vivax. symptoms of each infection may be mas ... | 2017 | 28049485 |
| comparison of stable and transient wolbachia infection models in aedes aegypti to block dengue and west nile viruses. | pathogen replication and transmission in wolbachia infected insects are currently studied using three wolbachia infection systems: naturally infected wolbachia hosts, hosts transinfected with wolbachia (stably maintained and inherited infections) and hosts transiently infected with wolbachia. all three systems have been used to test the effect of wolbachia on mosquito transmitted pathogens such as dengue virus (denv), west nile virus (wnv) and plasmodium. from these studies it is becoming increa ... | 2017 | 28052065 |
| evaluation of the importance of fever with respect to dengue prognosis according to the 2009 who classification: a retrospective study. | the 2009 revised world health organization (who) guidelines for dengue describe fever as the core symptom. accordingly, the diagnosis of non-febrile patients is complicated. the aim of this study was to evaluate the importance of fever in patients with dengue according to the 2009 revised who classification. | 2017 | 28052760 |
| functional analysis of the abcs of eye color in helicoverpa armigera with crispr/cas9-induced mutations. | many insect pigments are localized in subcellular pigment granules, and transport of pigment precursors from the cytoplasm is accomplished by abc proteins. drosophila melanogaster has three half-transporter genes (white, scarlet, and brown, all affecting eye pigments) and bombyx mori has a fourth (ok). the white, brown, scarlet and ok proteins each have one transmembrane and one cytoplasmic domain and they heterodimerize to form functional transporters with different substrate specificities. we ... | 2017 | 28053351 |
| data documenting the potential distribution of aedes aegypti in the center of veracruz, mexico. | the data presented in this article are related to the research article entitled "establishment of aedes aegypti (l.) in mountainous regions in mexico: increasing number of population at risk of mosquito-borne disease and future climate conditions" (m. equihua, s. ibáñez-bernal, g. benítez, i. estrada-contreras, c.a. sandoval-ruiz, f.s. mendoza-palmero, 2016) [1]. this article provides presence records in shapefile format used to generate maps of potential distribution of aedes aegypti with diffe ... | 2016 | 28054003 |
| identification and initial characterization of matrix metalloproteinases in the yellow fever mosquito, aedes aegypti. | aedes aegypti is a major vector for arboviruses such as dengue, chikungunya and zika viruses. during acquisition of a viremic bloodmeal, an arbovirus infects mosquito midgut cells before disseminating to secondary tissues, including the salivary glands. once virus is released into the salivary ducts it can be transmitted to another vertebrate host. the midgut is surrounded by a basal lamina (bl) in the extracellular matrix, consisting of a proteinaceous mesh composed of collagen iv and laminin. ... | 2017 | 28054419 |