Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| comparative pharmacological characterization of d1-like dopamine receptors from anopheles gambiae, aedes aegypti and culex quinquefasciatus suggests pleiotropic signaling in mosquito vector lineages. | small molecule antagonists of mosquito dopamine receptors (dars) are under investigation as a new class of vector-selective insecticides. antagonists that inhibit the d1-like dars aadop2 and cqdop2 from the mosquitoes aedes aegypti l. and culex quinquefasciatus say, respectively, also cause larval mortality in bioassays. here, we report on the orthologous dar, agdop2, from the malaria mosquito anopheles gambiae giles that was cloned and pharmacologically characterized in hek293 cells. larval bio ... | 2016 | 27048546 |
| comparative study of hippo pathway genes in cellular conveyor belts of a ctenophore and a cnidarian. | the hippo pathway regulates growth rate and organ size in fly and mouse, notably through control of cell proliferation. molecular interactions at the heart of this pathway are known to have originated in the unicellular ancestry of metazoans. they notably involve a cascade of phosphorylations triggered by the kinase hippo, with subsequent nuclear to cytoplasmic shift of yorkie localisation, preventing its binding to the transcription factor scalloped, thereby silencing proliferation genes. there ... | 2016 | 26900447 |
| duplication and diversification of dipteran argonaute genes, and the evolutionary divergence of piwi and aubergine. | genetic studies of drosophila melanogaster have provided a paradigm for rna interference (rnai) in arthropods, in which the microrna and antiviral pathways are each mediated by a single argonaute (ago1 and ago2) and germline suppression of transposable elements is mediated by a trio of piwi-subfamily argonaute proteins (ago3, aub, and piwi). without a suitable evolutionary context, deviations from this can be interpreted as derived or idiosyncratic. here we analyze the evolution of argonaute gen ... | 2016 | 26868596 |
| multiple functions of na/k-atpase in dopamine-induced salivation of the blacklegged tick, ixodes scapularis. | control of salivary secretion in ticks involves autocrine dopamine activating two dopamine receptors: d1 and invertebrate-specific d1-like dopamine receptors. in this study, we investigated na/k-atpase as an important component of the secretory process. immunoreactivity for na/k-atpase revealed basal infolding of lamellate cells in type-i, abluminal interstitial (epithelial) cells in type-ii, and labyrinth-like infolding structures opening towards the lumen in type-iii acini. ouabain (10 μmol l( ... | 2016 | 26861075 |
| mechanisms of sex determination and transmission ratio distortion in aedes aegypti. | more effective mosquito control strategies are urgently required due to the increasing prevalence of insecticide resistance. the sterile insect technique (sit) and the release of insects carrying a dominant lethal allele (ridl) are two proposed methods for environmentally-friendly, species-targeted population control. these methods may be more suitable for developing countries if producers reduce the cost of rearing insects. the cost of control programs could be reduced by producing all-male mos ... | 2016 | 26818000 |
| ligand selectivity in tachykinin and natalisin neuropeptidergic systems of the honey bee parasitic mite varroa destructor. | the varroa mite, varroa destructor, is a devastating ectoparasite of the honey bees apis mellifera and a. cerana. control of these mites in beehives is a challenge in part due to the lack of toxic agents that are specific to mites and not to the host honey bee. in searching for a specific toxic target of varroa mites, we investigated two closely related neuropeptidergic systems, tachykinin-related peptide (trp) and natalisin (ntl), and their respective receptors. honey bees lack both ntl and the ... | 2016 | 26817786 |
| first identification of kdr allele f1534s in vgsc gene and its association with resistance to pyrethroid insecticides in aedes albopictus populations from haikou city, hainan island, china. | aedes albopictus is distributed widely in china, as a primary vector of dengue fever and chikungunya fever in south of china. chemical insecticide control is one of the integrated programmes to prevent mosquito-borne diseases. long-term applications of pyrethroids have resulted in the development of resistance in ae. albopictus populations in china. however, the susceptibility of ae. albopictus to pyrethroids in hainan island was unclear. knockdown resistance (kdr), caused by point mutations in ... | 2016 | 27133234 |
| wolbachia blocks currently circulating zika virus isolates in brazilian aedes aegypti mosquitoes. | the recent association of zika virus with cases of microcephaly has sparked a global health crisis and highlighted the need for mechanisms to combat the zika vector, aedes aegypti mosquitoes. wolbachia pipientis, a bacterial endosymbiont of insect, has recently garnered attention as a mechanism for arbovirus control. here we report that aedes aegypti harboring wolbachia are highly resistant to infection with two currently circulating zika virus isolates from the recent brazilian epidemic. wolbac ... | 2016 | 27156023 |
| restriction to gene flow is associated with changes in the molecular basis of pyrethroid resistance in the malaria vector anopheles funestus. | resistance to pyrethroids, the sole insecticide class recommended for treating bed nets, threatens the control of major malaria vectors, including anopheles funestus effective management of resistance requires an understanding of the dynamics and mechanisms driving resistance. here, using genome-wide transcription and genetic diversity analyses, we show that a shift in the molecular basis of pyrethroid resistance in southern african populations of this species is associated with a restricted gen ... | 2016 | 28003461 |
| salivary gland proteome during adult development and after blood feeding of female anopheles dissidens mosquitoes (diptera: culicidae). | understanding changes in mosquito salivary proteins during the time that sporozoite maturation occurs and after blood feeding may give information regarding the roles of salivary proteins during the malarial transmission. anopheles dissidens (formerly anopheles barbirostris species a1) is a potential vector of plasmodium vivax in thailand. in this study, analyses of the proteomic profiles of female an. dissidens salivary glands during adult development and after blood feeding were carried out us ... | 2016 | 27669021 |
| proceedings of the ix international symposium on phlebotomine sandflies (isops ix), reims, france, june 28th-july 1st, 2016. | 2016 | 27677701 | |
| molecular identification of mosquitoes (diptera: culicidae) in southeastern australia. | dna barcoding is a modern species identification technique that can be used to distinguish morphologically similar species, and is particularly useful when using small amounts of starting material from partial specimens or from immature stages. in order to use dna barcoding in a surveillance program, a database containing mosquito barcode sequences is required. this study obtained cytochrome oxidase i (coi) sequences for 113 morphologically identified specimens, representing 29 species, six trib ... | 2016 | 27217948 |
| consolidating tactical planning and implementation frameworks for integrated vector management in uganda. | integrated vector management (ivm) is the recommended approach for controlling some vector-borne diseases (vbd). in the face of current challenges to disease vector control, ivm is vital to achieve national targets set for vbd control. though global efforts, especially for combating malaria, now focus on elimination and eradication, ivm remains useful for uganda which is principally still in the control phase of the malaria continuum. this paper outlines the processes undertaken to consolidate t ... | 2016 | 27074809 |
| a review of bioinsecticidal activity of solanaceae alkaloids. | only a small percentage of insect species are pests. however, pest species cause significant losses in agricultural and forest crops, and many are vectors of diseases. currently, many scientists are focused on developing new tools to control insect populations, including secondary plant metabolites, e.g., alkaloids, glycoalkaloids, terpenoids, organic acids and alcohols, which show promise for use in plant protection. these compounds can affect insects at all levels of biological organization, b ... | 2016 | 26938561 |
| contraceptive sales in the setting of the zika virus epidemic. | has there been any influence of the zika virus (zikv) outbreak on the sales of contraceptive methods in brazil? | 2016 | 27932442 |
| perspectives on the role of mobility, behavior, and time scales in the spread of diseases. | the dynamics, control, and evolution of communicable and vector-borne diseases are intimately connected to the joint dynamics of epidemiological, behavioral, and mobility processes that operate across multiple spatial, temporal, and organizational scales. the identification of a theoretical explanatory framework that accounts for the pattern regularity exhibited by a large number of host-parasite systems, including those sustained by host-vector epidemiological dynamics, is but one of the challe ... | 2016 | 27965394 |
| a historic report of zika in mozambique: implications for assessing current risk. | 2016 | 27930650 | |
| public health interventions for aedes control in the time of zikavirus- a meta-review on effectiveness of vector control strategies. | there is renewed interest in effective measures to control zika and dengue vectors. a synthesis of published literature with a focus on the quality of evidence is warranted to determine the effectiveness of vector control strategies. | 2016 | 27926934 |
| the self-regulation model of illness: comparison between zika and dengue and its application to predict mosquito prevention behaviours in malaysia, a dengue-endemic country. | perceptions about illnesses may influence self-care and preventive health behaviours. illness perceptions of the zika virus (zikv) infection were investigated under the framework of the self-regulation model of illness. illness perception differences between zikv and dengue fever were also examined. lastly, associations between illness perceptions of zikv with mosquito prevention practices were studied. samples were drawn from landline telephone numbers using computer-assisted telephone intervie ... | 2016 | 27929451 |
| comparative genomics of beauveria bassiana: uncovering signatures of virulence against mosquitoes. | entomopathogenic fungi such as beauveria bassiana are promising biological agents for control of malaria mosquitoes. indeed, infection with b. bassiana reduces the lifespan of mosquitoes in the laboratory and in the field. natural isolates of b. bassiana show up to 10-fold differences in virulence between the most and the least virulent isolate. in this study, we sequenced the genomes of five isolates representing the extremes of low/high virulence and three rna libraries, and applied a genome c ... | 2016 | 27905873 |
| tracking insecticide resistance in mosquito vectors of arboviruses: the worldwide insecticide resistance network (win). | 2016 | 27906961 | |
| human igg antibody response to aedes nterm-34kda salivary peptide, an epidemiological tool to assess vector control in chikungunya and dengue transmission area. | arboviral diseases are an important public health concerns. vector control remains the sole strategy to fight against these diseases. because of the important limits of methods currently used to assess human exposure to aedes mosquito bites, much effort is being devoted to develop new indicators. recent studies have reported that human antibody (ab) responses to aedes aegypti nterm-34kda salivary peptide represent a promising biomarker tool to evaluate the human-aedes contact. the present study ... | 2016 | 27906987 |
| prospects and challenges of crispr/cas genome editing for the study and control of neglected vector-borne nematode diseases. | neglected tropical diseases caused by parasitic nematodes inflict an immense health and socioeconomic burden throughout much of the developing world. current estimates indicate that more than two billion people are infected with nematodes, resulting in the loss of 14 million disability-adjusted life years per annum. although these parasites cause significant mortality, they primarily cause chronic morbidity through a wide range of severe clinical ailments. treatment options for nematode infectio ... | 2016 | 27300487 |
| metarhizium brunneum blastospore pathogenesis in aedes aegypti larvae: attack on several fronts accelerates mortality. | aedes aegypti is the vector of a wide range of diseases (e.g. yellow fever, dengue, chikungunya and zika) which impact on over half the world's population. entomopathogenic fungi such as metarhizium anisopliae and beauveria bassiana have been found to be highly efficacious in killing mosquito larvae but only now are the underlying mechanisms for pathogenesis being elucidated. recently it was shown that conidia of m. anisopliae caused stress induced mortality in ae. aegypti larvae, a different mo ... | 2016 | 27389584 |
| detecting guillain-barré syndrome caused by zika virus using systems developed for polio surveillance. | 2016 | 27708476 | |
| zika - an emerging global threat. | 2016 | 27822403 | |
| gut bacteria differentially affect egg production in the anautogenous mosquito aedes aegypti and facultatively autogenous mosquito aedes atropalpus (diptera: culicidae). | aedes aegypti and a. atropalpus are related mosquitoes that differ reproductively. aedes aegypti must blood-feed to produce eggs (anautogenous) while a. atropalpus always produces a first clutch of eggs without blood-feeding (facultatively autogenous). we recently characterized the gut microbiota of a. aegypti and a. atropalpus that were reared identically in the laboratory. here, we assessed the effects of specific members of the gut microbiota in a. aegypti and a. atropalpus on female fitness ... | 2016 | 27363842 |
| resistance status to the insecticides temephos, deltamethrin, and diflubenzuron in brazilian aedes aegypti populations. | insecticides are still largely applied in public health to control disease vectors. in brazil, organophosphates (op) and pyrethroids (py) are used against aedes aegypti for years. since 2009 insect growth regulators (igr) are also employed in the control of larvae. we quantified resistance to temephos (op), deltamethrin (py), and diflubenzuron (igr) of a. aegypti samples from 12 municipalities distributed throughout the country, collected between 2010 and 2012. high levels of resistance to neuro ... | 2016 | 27419140 |
| the current status of zika virus in southeast asia. | zika virus currently poses a global threat and is a major public health issue throughout latin america and the caribbean. however, zika virus infections in humans have also been observed in other regions, including southeast asia, where arboviral diseases are very common. in this study, we summarize the current status of zika virus in southeast asia. this review aims to provide an overview of the current situation and also to suggest ways of adequately managing the emergence of zika virus in sou ... | 2016 | 27336445 |
| the when and the where of zika epidemic potential in europe - an evidence base for public health preparedness. | 2016 | 27333025 | |
| potential risk of dengue and chikungunya outbreaks in northern italy based on a population model of aedes albopictus (diptera: culicidae). | the rapid invasion and spread of aedes albopictus (skuse, 1894) within new continents and climatic ranges has created favorable conditions for the emergence of tropical arboviral diseases in the invaded areas. we used mosquito abundance data from 2014 collected across ten sites in northern italy to calibrate a population model for aedes albopictus and estimate the potential of imported human cases of chikungunya or dengue to generate the condition for their autochthonous transmission in the abse ... | 2016 | 27304211 |
| zika virus in a traveler returning to china from caracas, venezuela, february 2016. | 2016 | 27070735 | |
| travel volume to the united states from countries and u.s. territories with local zika virus transmission. | air, land, and sea transportation can facilitate rapid spread of infectious diseases. in may 2015 the pan american health organization (paho) issued an alert regarding the first confirmed zika virus infection in brazil. as of march 8, 2016, the u.s. centers for disease control and prevention (cdc) had issued travel notices for 33 countries and 3 u.s. territories with local zika virus transmission. | 2016 | 27990321 |
| zika: what we do and do not know based on the experiences of brazil. | zika virus, which was first discovered in 1947, has become a global threat to human health as it is rapidly spreading through latin america, the caribbean, the us and asia, after causing a large outbreak in the northeast region of brazil in 2015. there is ample evidence to support that zika virus is associated with neurological complications such as microcephaly. the review aims to provide an overview on the complex issues involved in the emergence of zika virus's neurological disorders and to d ... | 2016 | 27283140 |
| using phenomenological models to characterize transmissibility and forecast patterns and final burden of zika epidemics. | the world health organization declared the ongoing zika virus (zikv) epidemic in the americas a public health emergency of international concern on february 1, 2016. zikv disease in humans is characterized by a "dengue-like" syndrome including febrile illness and rash. however, zikv infection in early pregnancy has been associated with severe birth defects, including microcephaly and other developmental issues. mechanistic models of disease transmission can be used to forecast trajectories and l ... | 2016 | 27366586 |
| zika in the united states of america and a fateful 1969 decision. | the united states gulf coast's current risk to zika transmitted by aedes aegypti mosquitoes can be traced back to some important federal health policy decisions made during the 1960s. | 2016 | 27227971 |
| efficacy of ulv and thermal aerosols of deltamethrin for control of aedes albopictus in nice, france. | ultra-low volume (ulv) insecticidal aerosols dispensed from vehicle-mounted cold-foggers are widely considered the method of choice for control of aedes aegypti and ae. albopictus during outbreaks of dengue and chikungunya and, more recently, zika. nevertheless, their effectiveness has been poorly studied, particularly in europe. nearly all published studies of ulv efficacy are bio-assays based on the mortality of caged mosquitoes. in our study we preferred to monitor the direct impact of treatm ... | 2016 | 27881181 |
| assessment of icount software, a precise and fast egg counting tool for the mosquito vector aedes aegypti. | widespread in the tropics, the mosquito aedes aegypti is an important vector of many viruses, posing a significant threat to human health. vector monitoring often requires fecundity estimation by counting eggs laid by female mosquitoes. traditionally, manual data analyses have been used but this requires a lot of effort and is the methods are prone to errors. an easy tool to assess the number of eggs laid would facilitate experimentation and vector control operations. | 2016 | 27863526 |
| hiv and zika: when will we be able to end these epidemics? | 2016 | 27846847 | |
| zika virus may affect the universal two-child policy: a new challenge for china. | 2016 | 27832058 | |
| pyriproxyfen and the microcephaly epidemic in brazil - an ecological approach to explore the hypothesis of their association. | the microcephaly epidemic in brazil generated intense debate regarding its causality, and one hypothesised cause of this epidemic, now recognised as congenital zika virus syndrome, was the treatment of drinking water tanks with pyriproxyfen to control aedes aegypti larvae. we present the results of a geographical analysis of the association between the prevalence of microcephaly confirmed by fenton growth charts and the type of larvicide used in the municipalities that were home to the mothers o ... | 2016 | 27812601 |
| near-infrared spectroscopy, a rapid method for predicting the age of male and female wild-type and wolbachia infected aedes aegypti. | estimating the age distribution of mosquito populations is crucial for assessing their capacity to transmit disease and for evaluating the efficacy of available vector control programs. this study reports on the capacity of the near-infrared spectroscopy (nirs) technique to rapidly predict the ages of the principal dengue and zika vector, aedes aegypti. the age of wild-type males and females, and males and females infected with wmel and wmelpop strains of wolbachia pipientis were characterized u ... | 2016 | 27768689 |
| analyzing climate variations at multiple timescales can guide zika virus response measures. | the emergence of zika virus (zikv) in latin america and the caribbean in 2014-2016 occurred during a period of severe drought and unusually high temperatures, conditions that have been associated with the 2015-2016 el niño event, and/or climate change; however, no quantitative assessment has been made to date. analysis of related flaviviruses transmitted by the same vectors suggests that zikv dynamics are sensitive to climate seasonality and longer-term variability and trends. a better understan ... | 2016 | 27716414 |
| genetic variability and spatial distribution in small geographic scale of aedes aegypti (diptera: culicidae) under different climatic conditions in northeastern brazil. | the study of the genetic structure of aedes aegypti is essential to understanding their population dynamics as well as for the analysis of factors responsible for their resistance and ecological adaptation. the use of molecular markers in identifying differences amongst populations of ae. aegypti in different geographical areas as well as the temporal variation of the vector populations has contributed to the improvement of vector control strategies. the present study aims to determine the genet ... | 2016 | 27716392 |
| first detection of natural infection of aedes aegypti with zika virus in brazil and throughout south america. | zika virus (zikv) has caused a major epidemic in brazil and several other american countries. zikv is an arbovirus whose natural vectors during epidemics have been poorly determined. in this study, 1,683 mosquitoes collected in the vicinity of zikv suspected cases in rio de janeiro, brazil, from june 2015 to may 2016 were screened for natural infection by using molecular methods. three pools of aedes aegypti were found with the zikv genome, one of which had only one male. this finding supports t ... | 2016 | 27706382 |
| yellow fever-more a policy and planning problem than a biological one. | 2016 | 27479749 | |
| oviposition ecology and species composition of aedes spp. and aedes aegypti dynamics in variously urbanized settings in arbovirus foci in southeastern côte d'ivoire. | aedes mosquito-transmitted outbreaks of dengue and yellow fever have been reported from rural and urban parts of côte d'ivoire. the present study aimed at assessing aedes spp. oviposition ecology in variously urbanized settings within arbovirus foci in southeastern côte d'ivoire. | 2016 | 27682270 |
| vector competence of french polynesian aedes aegypti and aedes polynesiensis for zika virus. | in 2013-2014, french polynesia experienced for the first time a zika outbreak. two aedes mosquitoes may have contributed to zika virus (zikv) transmission in french polynesia: the worldwide distributed ae. aegypti and the polynesian islands-endemic ae. polynesiensis mosquito. | 2016 | 27654962 |
| assessment of local mosquito species incriminates aedes aegypti as the potential vector of zika virus in australia. | within the last 10 years zika virus (zikv) has caused unprecedented epidemics of human disease in the nations and territories of the western pacific and south america, and continues to escalate in both endemic and non-endemic regions. we evaluated the vector competence of australian mosquitoes for zikv to assess their potential role in virus transmission. | 2016 | 27643685 |
| insights into zika virus history, human health effects, and control measures. | 2016 | 27679523 | |
| predicting dengue fever outbreaks in french guiana using climate indicators. | dengue fever epidemic dynamics are driven by complex interactions between hosts, vectors and viruses. associations between climate and dengue have been studied around the world, but the results have shown that the impact of the climate can vary widely from one study site to another. in french guiana, climate-based models are not available to assist in developing an early warning system. this study aims to evaluate the potential of using oceanic and atmospheric conditions to help predict dengue f ... | 2016 | 27128312 |
| spread of the invasive mosquitoes aedes aegypti and aedes albopictus in the black sea region increases risk of chikungunya, dengue, and zika outbreaks in europe. | 2016 | 27115737 | |
| external quality assessment of dengue and chikungunya diagnostics in the asia pacific region, 2015. | to conduct an external quality assessment (eqa) of dengue and chikungunya diagnostics among national-level public health laboratories in the asia pacific region following the first round of eqa for dengue diagnostics in 2013. | 2016 | 27508088 |
| the mitotic spindle: linking teratogenic effects of zika virus with human genetics? | recently, an association between zika virus infection and microcephaly/ocular findings was found to be reasonable e.g. because of the demonstration that the virus was found in the brain of a fetus after presumed maternal infection. although there is no proof yet for a causal relationship, for an appropriate risk calculation efforts are urgently needed to either establish or disprove this assumption. | 2016 | 27099632 |
| characterization of lethal zika virus infection in ag129 mice. | mosquito-borne zika virus (zikv) typically causes a mild and self-limiting illness known as zika fever, which often is accompanied by maculopapular rash, headache, and myalgia. during the current outbreak in south america, zikv infection during pregnancy has been hypothesized to cause microcephaly and other diseases. the detection of zikv in fetal brain tissue supports this hypothesis. because human infections with zikv historically have remained sporadic and, until recently, have been limited t ... | 2016 | 27093158 |
| microcephaly and zika virus: neonatal neuroradiological aspects. | the aim of this study is to describe some radiological features in the newborns with microcephaly caused by zika virus infection during pregnancy. | 2016 | 27080092 |
| clinical features and neuroimaging (ct and mri) findings in presumed zika virus related congenital infection and microcephaly: retrospective case series study. | to report radiological findings observed in computed tomography (ct) and magnetic resonance imaging (mri) scans of the first cases of congenital infection and microcephaly presumably associated with the zika virus in the current brazilian epidemic. | 2016 | 27075009 |
| the zika pandemic - a perfect storm? | 2016 | 26991663 | |
| zika: structuring the european research response. | studies are needed to assess #zika virus risks and to develop diagnostic tests http://ow.ly/zaozw. | 2016 | 27730165 |
| on the seasonal occurrence and abundance of the zika virus vector mosquito aedes aegypti in the contiguous united states. | an ongoing zika virus pandemic in latin america and the caribbean has raised concerns that travel-related introduction of zika virus could initiate local transmission in the united states (u.s.) by its primary vector, the mosquito aedes aegypti. | 2016 | 27066299 |
| zika virus outbreak: 'a perfect storm'. | 2016 | 26956448 | |
| differential susceptibilities of aedes aegypti and aedes albopictus from the americas to zika virus. | since the major outbreak in 2007 in the yap island, zika virus (zikv) causing dengue-like syndromes has affected multiple islands of the south pacific region. in may 2015, the virus was detected in brazil and then spread through south and central america. in december 2015, zikv was detected in french guiana and martinique. the aim of the study was to evaluate the vector competence of the mosquito spp. aedes aegypti and aedes albopictus from the caribbean (martinique, guadeloupe), north america ( ... | 2016 | 26938868 |
| the expanding spectrum of modes of transmission of zika virus: a global concern. | 2016 | 26939897 | |
| highly divergent dengue virus type 1 genotype sets a new distance record. | dengue viruses (denvs) are the leading cause of mosquito-borne viral disease of humans. they exist in both endemic and sylvatic ecotypes. in 2014, a viremic patient who had recently visited the rainforests of brunei returned to australia displaying symptoms consistent with denv infection. a unique denv strain was subsequently isolated from the patient, which we propose belongs to a new genotype within denv serotype 1 (denv-1). bayesian evolutionary phylogenetic analysis suggests that the putativ ... | 2016 | 26924208 |
| zika virus infection: new threat in global health. | 2016 | 26955231 | |
| larvicidal potential of the halogenated sesquiterpene (+)-obtusol, isolated from the alga laurencia dendroidea j. agardh (ceramiales: rhodomelaceae), against the dengue vector mosquito aedes aegypti (linnaeus) (diptera: culicidae). | dengue is considered a serious public health problem in many tropical regions of the world including brazil. at the moment, there is no viable alternative to reduce dengue infections other than controlling the insect vector, aedes aegypti linnaeus. in the continuing search for new sources of chemicals targeted at vector control, natural products are a promising alternative to synthetic pesticides. in our work, we investigated the toxicity of a bioactive compound extracted from the red alga laure ... | 2016 | 26821032 |
| anticipating the international spread of zika virus from brazil. | 2016 | 26777915 | |
| the genetic basis of host preference and resting behavior in the major african malaria vector, anopheles arabiensis. | malaria transmission is dependent on the propensity of anopheles mosquitoes to bite humans (anthropophily) instead of other dead end hosts. recent increases in the usage of long lasting insecticide treated nets (llins) in africa have been associated with reductions in highly anthropophilic and endophilic vectors such as anopheles gambiae s.s., leaving species with a broader host range, such as anopheles arabiensis, as the most prominent remaining source of transmission in many settings. an. arab ... | 2016 | 27631375 |
| bacterial larvicide, bacillus thuringiensis israelensis strain am 65-52 water dispersible granule formulation impacts both dengue vector, aedes aegypti (l.) population density and disease transmission in cambodia. | a multi-phased study was conducted in cambodia from 2005-2011 to measure the impact of larviciding with the bacterial larvicide, bacillus thuringiensis israelensis (bti), a water dispersible granule (wg) formulation on the vector, aedes aegypti (l.) and the epidemiology. in our studies, all in-use containers were treated at 8 g/1000 l, including smaller containers and animal feeders which were found to contribute 23% of ae aegypti pupae. the treated waters were subjected to routine water exchang ... | 2016 | 27627758 |
| zika: an old virus with a new face. | zika virus is a mosquito-borne flavivirus that represents a public health emergency at the ongoing epidemic. this obscure virus was limited to sporadic cases in africa and asia, until the emergence of zika virus in brazil in 2015, when it rapidly spread throughout the americas. most zika virus infections are subclinical or characterized by mild febrile illness. however, neurological complications, including guillain-barré syndrome in adults, and congenital anomalies, including microcephaly in ba ... | 2016 | 27703544 |
| isolation of zika virus imported from tonga into australia. | the globally emergent zika virus (zikv) is a threat to australia, given the number of imported cases from epidemic regions and the presence of competent mosquito vectors. we report the isolation of zikv from a female traveler who recently returned from tonga to brisbane, queensland, australia in 2016. | 2016 | 27679739 |
| use of transgenic aedes aegypti in brazil: risk perception and assessment. | the ox513a strain of aedes aegypti, which was developed by the british company oxitec, expresses a self-limiting transgene that prevents larvae from developing to adulthood. in april 2014, the brazilian national technical commission on biosafety completed a risk assessment of ox513a and concluded that the strain did not present new biological risks to humans or the environment and could be released in brazil. at that point, brazil became the first country to approve the unconstrained release of ... | 2016 | 27843167 |
| an ecological assessment of the pandemic threat of zika virus. | the current outbreak of zika virus poses a severe threat to human health. while the range of the virus has been cataloged growing slowly over the last 50 years, the recent explosive expansion in the americas indicates that the full potential distribution of zika remains uncertain. moreover, many studies rely on its similarity to dengue fever, a phylogenetically closely related disease of unknown ecological comparability. here we compile a comprehensive spatially-explicit occurrence dataset from ... | 2016 | 27564232 |
| complete genome sequences of three historically important, spatiotemporally distinct, and genetically divergent strains of zika virus: mr-766, p6-740, and prvabc-59. | here, we report the 10,807-nucleotide-long consensus rna genome sequences of three spatiotemporally distinct and genetically divergent zika virus strains, with the functionality of their genomic sequences substantiated by reverse genetics: mr-766 (african lineage, uganda, 1947), p6-740 (asian lineage, malaysia, 1966), and prvabc-59 (asian lineage-derived american strain, puerto rico, 2015). | 2016 | 27540058 |
| zika virus: a call to action for physicians in the era of climate change. | in february 2016, the world health organization declared the mosquito-borne zika virus to be a "public health emergency of international concern" as the disease linked to thousands of birth defects in brazil spreads rapidly. the distribution of the aedes mosquitos has drastically increased over the past few decades, which have been the hottest decades on earth in more than 1000 years based on climate proxy measures. although a combination of factors explains the current zika virus outbreak, it's ... | 2016 | 27617189 |
| the importance of male body size on sperm uptake and usage, and female fecundity in aedes aegypti and aedes albopictus. | adult mosquito density is a critical factor in the transmission of arboviruses by container aedes spp. mosquitoes. female fecundity drives population growth, and therefore contributes to adult mosquito density. previous studies have focused on female body size as the major determinant of fecundity, paying little attention to male condition. in this study, we examined the effects of male body size on the abundance of sperm in spermatheca, depletion of sperm over time, and female fecundity. | 2016 | 27519588 |
| the critical role of early dengue surveillance and limitations of clinical reporting - implications for non-endemic countries. | the increasing dengue burden and epidemic severity worldwide have highlighted the need to improve surveillance. in non-endemic areas such as taiwan, where outbreaks start mostly with imported cases from southeast asia, a closer examination of surveillance dynamics to detect cases early is necessary. to evaluate problems with dengue surveillance and investigate the involvement of different factors at various epidemic stages, we investigated 632 laboratory-confirmed indigenous dengue cases in kaoh ... | 2016 | 27501302 |
| genetically modified (gm) mosquito use to reduce mosquito-transmitted disease in the us: a community opinion survey. | mosquito-borne infectious diseases such as dengue, chikungunya, and now zika, pose a public health threat to the us, particularly florida, the gulf coast states, and hawaii. recent autochthonous transmission of dengue and chikungunya in florida, the recent dengue outbreak in hawaii, and the potential for future local spread of zika in the us, has led to the consideration of novel approaches to mosquito management. one such novel approach, the release of sterile genetically modified mosquitoes, h ... | 2016 | 27366585 |
| a sequence of flushing and drying of breeding habitats of aedes aegypti (l.) prior to the low dengue season in singapore. | in dengue-endemic areas, transmission shows both a seasonal and interannual variability. to investigate how rainfall impacts dengue seasonality in singapore, we carried out a longitudinal survey in the geylang neighborhood from august 2014 to august 2015. the survey comprised of twice-weekly random inspections to outdoor breeding habitats and continuous monitoring for positive ones. in addition, observations of rainstorms were collected. out of 6824 inspected habitats, 67 contained aedes aegypti ... | 2016 | 27459322 |
| a review of chikungunya virus-induced arthralgia: clinical manifestations, therapeutics, and pathogenesis. | chikungunya virus (chikv) is a mosquito-borne alphavirus that circulates predominantly in tropical and subtropical regions, potentially affecting over 1 billion people. recently, an outbreak began in the western hemisphere and has resulted in over 1.8 million reported suspected cases. infection often results in severe fever, rash and debilitating polyarthralgia lasting weeks to months. additionally, the current literature reports that chikv can result in a severe chronic arthralgia and/or arthri ... | 2016 | 28077980 |
| analysis of chikungunya virus proteins reveals that non-structural proteins nsp2 and nsp3 exhibit rna interference (rnai) suppressor activity. | rnai pathway is an antiviral defence mechanism employed by insects that result in degradation of viral rna thereby curbing infection. several viruses including flaviviruses encode viral suppressors of rnai (vsrs) to counteract the antiviral rnai pathway. till date, no vsr has been reported in alphaviruses. the present study was undertaken to evaluate chikungunya virus (chikv) proteins for rnai suppressor activity. we systematically analyzed all nine chikv proteins for rnai suppressor activity us ... | 2016 | 27901124 |
| diet-induced nutritional stress and pathogen interference in wolbachia-infected aedes aegypti. | the pathogen interference phenotype greatly restricts infection with dengue virus (denv) and other pathogens in wolbachia-infected aedes aegypti, and is a vital component of wolbachia-based mosquito control. critically, the phenotype's causal mechanism is complex and poorly understood, with recent evidence suggesting that the cause may be species specific. to better understand this important phenotype, we investigated the role of diet-induced nutritional stress on interference against denv and t ... | 2016 | 27893736 |
| cross-mating compatibility and competitiveness among aedes albopictus strains from distinct geographic origins - implications for future application of sit programs in the south west indian ocean islands. | the production of large numbers of males needed for a sustainable sterile insect technique (sit) control program requires significant developmental and operational costs. this may constitute a significant economic barrier to the installation of large scale rearing facilities in countries that are undergoing a transition from being largely dependent on insecticide use to be in a position to integrate the sit against aedes albopictus. alternative options available for those countries could be to r ... | 2016 | 27806056 |
| recent chikungunya virus infection in 2 travelers returning from mogadishu, somalia, to italy, 2016. | 2016 | 27513985 | |
| chikungunya virus infection: an update on joint manifestations and management. | the advent of sophisticated diagnostics has enabled the discovery of previously unknown arthropod-borne viruses like chikungunya. this infection has become increasingly prevalent in the last 10 years across the indian ocean and has been brought to media attention by a recent outbreak in the caribbean. the outbreak has been aided by a drastic rise in air travel, allowing infected individuals to transport the virus to previously unaffected regions. in addition, a recently documented viral mutation ... | 2016 | 27824550 |
| in silico study on anti-chikungunya virus activity of hesperetin. | the re-emerging, aedes spp. transmitted chikungunya virus (chikv) has recently caused large outbreaks in a wide geographical distribution of the world including countries in europe and america. though fatalities associated with this self-remitting disease were rarely reported, quality of patients' lives have been severely diminished by polyarthralgia recurrence. neither effective antiviral treatment nor vaccines are available for chikv. our previous in vitro screening showed that hesperetin, a b ... | 2016 | 27812412 |
| use of household cluster investigations to identify factors associated with chikungunya virus infection and frequency of case reporting in puerto rico. | chikungunya virus (chikv) is transmitted by aedes species mosquitoes and is the cause of an acute febrile illness characterized by potentially debilitating arthralgia. after emerging in the caribbean in late 2013, the first locally-acquired case reported to public health authorities in puerto rico occurred in may 2014. during june-august 2014, household-based cluster investigations were conducted to identify factors associated with infection, development of disease, and case reporting. | 2016 | 27764085 |
| chikungunya virus transmission between aedes albopictus and laboratory mice. | chikungunya virus (chikv) is a mosquito-borne alphavirus associated with epidemics of acute and chronic arthritic disease in humans. aedes albopictus has emerged as an important new natural vector for chikv transmission; however, mouse models for studying transmission have not been developed. | 2016 | 27760560 |
| mapping of courses on vector biology and vector-borne diseases systems: time for a worldwide effort. | major emergency efforts are being mounted for each vector-borne disease epidemiological crisis anew, while knowledge about the biology of arthropods vectors is dwindling slowly but continuously, as is the number of field entomologists. the discrepancy between the rates of production of knowledge and its use and need for solving crises is widening, in particular due to the highly differing time spans of the two concurrent processes. a worldwide web based search using multiple key words and search ... | 2016 | 27759770 |
| chikungunya virus in febrile humans and aedes aegypti mosquitoes, yucatan, mexico. | chikungunya virus (chikv) was isolated from 12 febrile humans in yucatan, mexico, in 2015. one patient was co-infected with dengue virus type 1. two additional chikv isolates were obtained from aedes aegypti mosquitoes collected in the homes of patients. phylogenetic analysis showed that the chikv isolates belong to the asian lineage. | 2016 | 27347760 |
| climate change influences potential distribution of infected aedes aegypti co-occurrence with dengue epidemics risk areas in tanzania. | dengue is the second most important vector-borne disease of humans globally after malaria. incidence of dengue infections has dramatically increased recently, potentially due to changing climate. climate projections models predict increases in average annual temperature, precipitation and extreme events in the future. the objective of this study was to assess the effect of changing climate on distribution of dengue vectors in relation to epidemic risk areas in tanzania. | 2016 | 27681327 |
| culex quinquefasciatus from rio de janeiro is not competent to transmit the local zika virus. | the americas have suffered a dramatic epidemic of zika since may in 2015, when zika virus (zikv) was first detected in brazil. mosquitoes belonging to subgenus stegomyia of aedes, particularly aedes aegypti, are considered the primary vectors of zikv. however, the rapid spread of the virus across the continent raised several concerns about the transmission dynamics, especially about potential mosquito vectors. the purpose of this work was to assess the vector competence of the house mosquito cul ... | 2016 | 27598421 |
| knowledge and use of prevention measures for chikungunya virus among visitors - virgin islands national park, 2015. | in june 2014, the mosquito-borne chikungunya virus (chikv) emerged in the u.s. virgin islands (usvi), a location where tourists comprise the majority of the population during peak season (january-april). limited information is available concerning visitors' chikv awareness and prevention measures. | 2016 | 27597388 |
| genetic evidence of expansion by passive transport of aedes (stegomyia) aegypti in eastern argentina. | 2016 | 27583521 | |
| zika virus, a new threat for europe? | since its emergence in 2007 in micronesia and polynesia, the arthropod-borne flavivirus zika virus (zikv) has spread in the americas and the caribbean, following first detection in brazil in may 2015. the risk of zikv emergence in europe increases as imported cases are repeatedly reported. together with chikungunya virus (chikv) and dengue virus (denv), zikv is transmitted by aedes mosquitoes. any countries where these mosquitoes are present could be potential sites for future zikv outbreak. we ... | 2016 | 27505002 |
| expression and characterization of yeast derived chikungunya virus like particles (chik-vlps) and its evaluation as a potential vaccine candidate. | chikungunya virus (chikv) has emerged as a global health concern due to its recent spread in both old and new world. so far, no chikv specific drug or vaccine is licensed for human use. in this study, we report production of chikungunya virus like particles (chik-vlps) using novel yeast expression system (pichia pastoris) and its evaluation as vaccine candidate. the gene encoding structural polyprotein of chikv from a recent epidemic strain was cloned into yeast expression system. the multicopy ... | 2016 | 27399001 |
| vector competence of aedes aegypti in transmitting chikungunya virus: effects and implications of extrinsic incubation temperature on dissemination and infection rates. | aedes aegypti is a competent arthropod vector of chikungunya virus (chikv). the rate at which the virus disseminate in the vector is limited by temperature of their environment which can be an important determinant of geographical and seasonal limits to transmission by the arthropods in the tropics. this study investigated the vector competence of ae. aegypti for chikv at ambient temperature of 32 and 26 °c (coastal and western kenya respectively) reared at extrinsic incubation temperature (eit) ... | 2016 | 27357190 |
| development of neutralization assay using an egfp chikungunya virus. | chikungunya virus (chikv), a member of the alphavirus genus, is an important human emerging/re-emerging pathogen. currently, there are no effective antiviral drugs or vaccines against chikv infection. herein, we construct an infectious clone of chikv and an egfp reporter chikv (egfp-chikv) with an isolated strain (assigned to asian lineage) from chikv-infected patients. the egfp-chikv reporter virus allows for direct visualization of viral replication through the levels of egfp expression. using ... | 2016 | 27367716 |
| isolation of infective zika virus from urine and saliva of patients in brazil. | zika virus (zikv) is an emergent threat provoking a worldwide explosive outbreak. since january 2015, 41 countries reported autochthonous cases. in brazil, an increase in guillain-barré syndrome and microcephaly cases was linked to zikv infections. a recent report describing low experimental transmission efficiency of its main putative vector, ae. aegypti, in conjunction with apparent sexual transmission notifications, prompted the investigation of other potential sources of viral dissemination. ... | 2016 | 27341420 |
| seroprevalence of anti-chikungunya virus antibodies in children and adults in managua, nicaragua, after the first chikungunya epidemic, 2014-2015. | chikungunya is a viral disease transmitted by aedes aegypti and ae. albopictus mosquitoes. in late 2013, chikungunya virus (chikv) was introduced into the caribbean island of st. martin. since then, approximately 2 million chikungunya cases have been reported by the pan american health organization, and most countries in the americas report autochthonous transmission of chikv. in nicaragua, the first imported case was described in july 2014 and the first autochthonous case in september 2014. her ... | 2016 | 27322692 |