Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| ran involved in the development and reproduction is a potential target for rna-interference-based pest management in nilaparvata lugens. | ran (rangtpase) in insects participates in the 20-hydroxyecdysone signal transduction pathway in which downstream genes, ftz-f1, krüppel-homolog 1 (kr-h1) and vitellogenin, are involved. a putative ran gene (nlran) was cloned from nilaparvata lugens, a destructive phloem-feeding pest of rice. nlran has the typical ran primary structure features that are conserved in insects. nlran showed higher mrna abundance immediately after molting and peaked in newly emerged female adults. among the examined ... | 2015 | 26554926 |
| the impact of wolbachia on virus infection in mosquitoes. | mosquito-borne viruses such as dengue, west nile and chikungunya viruses cause significant morbidity and mortality in human populations. since current methods are not sufficient to control disease occurrence, novel methods to control transmission of arboviruses would be beneficial. recent studies have shown that virus infection and transmission in insects can be impeded by co-infection with the bacterium wolbachia pipientis. wolbachia is a maternally inherited endosymbiont that is commonly found ... | 2015 | 26556361 |
| psychiatric morbidity in patients with chikungunya fever: first report from india. | chikungunya fever is an acute illness caused by an arbovirus and has various complications like neurological, psychological, dermatological and even multi organ failure. psychiatric co-morbidity is not very well studied till now. this is the first report from india. | 2015 | 26557595 |
| dengue fever as a cause of hemophagocytic lymphohistiocytosis. | dengue is endemic in more than 100 countries in southeast asia, the americas, the western pacific, africa and the eastern mediterranean regions. the virus is transmitted by aedes mosquitoes. dengue disease is the most prevalent arthropod-borne viral disease in humans and is a global and national public health concern in several countries. a seasonal pattern of dengue disease is consistently observed. the highest incidences usually correspond to the period of highest rainfall and humidity, provid ... | 2015 | 26558245 |
| identification and analysis of the set-domain family in silkworm, bombyx mori. | as an important economic insect, bombyx mori is also a useful model organism for lepidopteran insect. set-domain-containing proteins belong to a group of enzymes named after a common domain that utilizes the cofactor s-adenosyl-l-methionine (sam) to achieve methylation of its substrates. many set-domain-containing proteins have been shown to display catalytic activity towards particular lysine residues on histones, but emerging evidence also indicates that various nonhistone proteins are specifi ... | 2015 | 26558257 |
| resource limitation, controphic ostracod density and larval mosquito development. | aquatic environments can be restricted with the amount of available food resources especially with changes to both abiotic and biotic conditions. mosquito larvae, in particular, are sensitive to changes in food resources. resource limitation through inter-, and intra-specific competition among mosquitoes are known to affect both their development and survival. however, much less is understood about the effects of non-culicid controphic competitors (species that share the same trophic level). to ... | 2015 | 26558896 |
| innate antiviral immunity against dengue virus. | dengue virus (denv), the most prevalent mosquito-borne viral diseases in humans worldwide, causes dengue fever, a mild form of the disease, as well as dengue hemorrhagic fever/dengue shock syndrome, a more severe form which can be life-threatening. the four serotypes of denv (denv1-4) are positive-sense, single stranded rna virus belonging to the flaviviridae family and are transmitted by aedes aegypti and aedes albopictus mosquitoes. together, they are estimated to cause almost 100 million symp ... | 2015 | 26559229 |
| immunogenicity and protective efficacy of brugia malayi heavy chain myosin as homologous dna, protein and heterologous dna/protein prime boost vaccine in rodent model. | we earlier demonstrated the immunoprophylactic efficacy of recombinant heavy chain myosin (bm-myo) of brugia malayi (b. malayi) in rodent models. in the current study, further attempts have been made to improve this efficacy by employing alternate approaches such as homologous dna (pcd-myo) and heterologous dna/protein prime boost (pcd-myo+bm-myo) in balb/c mouse model. the gene bm-myo was cloned in a mammalian expression vector pcdna 3.1(+) and protein expression was confirmed in mammalian vero ... | 2015 | 26560102 |
| a re-examination of the history of etiologic confusion between dengue and chikungunya. | contrary to the perception of many researchers that the recent invasion of chikungunya (chik) in the western hemisphere marked the first episode in history, a recent publication reminded them that chik had prevailed in the west indies and southern regions of the united states from 1827-1828 under the guise of "dengue" (den), and that many old outbreaks of so-called "dengue" actually represented the chik cases erroneously identified as "dengue." in hindsight, this confusion was unavoidable, given ... | 2015 | 26562299 |
| production of infectious dengue virus in aedes aegypti is dependent on the ubiquitin proteasome pathway. | dengue virus (denv) relies on host factors to complete its life cycle in its mosquito host for subsequent transmission to humans. denv first establishes infection in the midgut of aedes aegypti and spreads to various mosquito organs for lifelong infection. curiously, studies have shown that infectious denv titers peak and decrease thereafter in the midgut despite relatively stable viral genome levels. however, the mechanisms that regulate this decoupling of infectious virion production from vira ... | 2015 | 26566123 |
| negative feedbacks by isoprenoids on a mevalonate kinase expressed in the corpora allata of mosquitoes. | juvenile hormones (jh) regulate development and reproductive maturation in insects. jhs are synthesized through the mevalonate pathway (mvap), an ancient metabolic pathway present in the three domains of life. mevalonate kinase (mvk) is a key enzyme in the mvap. mvk catalyzes the synthesis of phosphomevalonate (pm) by transferring the γ-phosphoryl group from atp to the c5 hydroxyl oxygen of mevalonic acid (ma). despite the importance of mvks, these enzymes have been poorly characterized in insec ... | 2015 | 26566274 |
| surveillance of dengue vectors using spatio-temporal bayesian modeling. | at present, dengue control focuses on reducing the density of the primary vector for the disease, aedes aegypti, which is the only vulnerable link in the chain of transmission. the use of new approaches for dengue entomological surveillance is extremely important, since present methods are inefficient. with this in mind, the present study seeks to analyze the spatio-temporal dynamics of a. aegypti infestation with oviposition traps, using efficient computational methods. these methods will allow ... | 2015 | 26566610 |
| microbiota-dependent priming of antiviral intestinal immunity in drosophila. | enteric pathogens must overcome intestinal defenses to establish infection. in drosophila, the erk signaling pathway inhibits enteric virus infection. the intestinal microflora also impacts immunity but its role in enteric viral infection is unknown. here we show that two signals are required to activate antiviral erk signaling in the intestinal epithelium. one signal depends on recognition of peptidoglycan from the microbiota, particularly from the commensal acetobacter pomorum, which primes th ... | 0 | 26567510 |
| genomic mining reveals deep evolutionary relationships between bornaviruses and bats. | bats globally harbor viruses in order mononegavirales, such as lyssaviruses and henipaviruses; however, little is known about their relationships with bornaviruses. previous studies showed that viral fossils of bornaviral origin are embedded in the genomes of several mammalian species such as primates, indicative of an ancient origin of exogenous bornaviruses. in this study, we mined the available 10 bat genomes and recreated a clear evolutionary relationship of endogenous bornaviral elements an ... | 2015 | 26569285 |
| dissecting vectorial capacity for mosquito-borne viruses. | the inter-relationship between mosquitoes and the viruses they transmit is complex. while previously understood barriers to infection and transmission remain valid, additional factors have been uncovered that suggest an 'arms race' between mosquito and virus. these include the mosquito microbiota and interplay between mosquito and viral genetics. following an infectious blood meal, the mosquito mounts an immune and transcriptional response, leading to altered expression of multiple genes. these ... | 2015 | 26569343 |
| the impact of indoor residual spraying of deltamethrin on dengue vector populations in the peruvian amazon. | dengue is an important public health problem in the amazon area of peru, resulting in significant morbidity each year. as in other areas of the world, ultra-low volume (ulv) application of insecticides is the main strategy to reduce adult populations of the dengue vector aedes aegypti, despite growing evidence of its limitations as a single control method. this study investigated the efficacy of deltamethrin s.c. applied through indoor residual spraying (irs) of dwellings in reducing a. aegypti ... | 2016 | 26571068 |
| severe dengue fever outbreak in taiwan. | dengue fever (df) is a vector-borne disease caused by dengue viruses (denvs). epidemic dengue occurs intermittently in taiwan. in 2014, taiwan experienced its largest df outbreak. there were 15,732 df cases reported. there were a total of 136 dengue hemorrhagic fever (dhf) cases, of which 20 resulted in death. most df cases were reported in southern taiwan. a total of 15,043 (96%) cases were from kaohsiung, a modern city in southern taiwan. this report reviews df epidemics in taiwan during 2005- ... | 2015 | 26572871 |
| transcription analysis of neonicotinoid resistance in mediterranean (med) populations of b. tabaci reveal novel cytochrome p450s, but no nachr mutations associated with the phenotype. | bemisia tabaci is one of the most damaging agricultural pests world-wide. although its control is based on insecticides, b. tabaci has developed resistance against almost all classes of insecticides, including neonicotinoids. | 2015 | 26573457 |
| characterization and mosquitocidal potential of neem cake-synthesized silver nanoparticles: genotoxicity and impact on predation efficiency of mosquito natural enemies. | mosquitoes (diptera: culicidae) serve as important vectors for a wide number of parasites and pathogens of huge medical and veterinary importance. aedes aegypti is a primary dengue vector in tropical and subtropical urban areas. there is an urgent need to develop eco-friendly mosquitocides. in this study, silver nanoparticles (agnp) were biosynthesized using neem cake, a by-product of the neem oil extraction from the seed kernels of azadirachta indica. agnp were characterized using a variety of ... | 2016 | 26573518 |
| identification of a major quantitative trait locus determining resistance to the organophosphate temephos in the dengue vector mosquito aedes aegypti. | organophosphate insecticides (op) have extensively been used to control mosquitoes, such as the vector aedes aegypti. unfortunately, op resistance has hampered control programs worldwide. we used quantitative trait locus (qtl) mapping to evaluate temephos resistance in two f1 intercross populations derived from crosses between a resistant ae. aegypti strain (recr) and two susceptible strains (moyod and red). a single major effect qtl was identified on chromosome 2 of both segregating populations ... | 2016 | 26576515 |
| spatial and temporal variation in aedes aegypti and aedes albopictus (diptera: culicidae) numbers in the yogyakarta area of java, indonesia, with implications for wolbachia releases. | of mosquito vector populations, particularly through wolbachia endosymbionts. the success of these strategies depends on understanding the dynamics of vector populations. in preparation for wolbachia releases around yogyakarta, we have studied aedes populations in five hamlets. adult monitoring with biogent- sentinel (bg-s) traps indicated that hamlet populations had different dynamics across the year; while there was an increase in aedes aegypti (l.) and aedes albopictus (skuse) numbers in the ... | 2016 | 26576934 |
| the use of a chemically defined artificial diet as a tool to study aedes aegypti physiology. | aedes aegypti mosquitoes obtain from vertebrate blood nutrients that are essential to oogenesis, such as proteins and lipids. as with all insects, mosquitoes do not synthesize cholesterol but take it from the diet. here, we used a chemically defined artificial diet, hereafter referred to as substitute blood meal (sbm), that was supplemented with cholesterol to test the nutritional role of cholesterol. sbm-fed and blood-fed mosquitoes were compared regarding several aspects of the insect physiolo ... | 2015 | 26578294 |
| insectbase: a resource for insect genomes and transcriptomes. | the genomes and transcriptomes of hundreds of insects have been sequenced. however, insect community lacks an integrated, up-to-date collection of insect gene data. here, we introduce the first release of insectbase, available online at http://www.insect-genome.com. the database encompasses 138 insect genomes, 116 insect transcriptomes, 61 insect gene sets, 36 gene families of 60 insects, 7544 mirnas of 69 insects, 96,925 pirnas of drosophila melanogaster and chilo suppressalis, 2439 lncrna of n ... | 2015 | 26578584 |
| multitasking roles of mosquito labrum in oviposition and blood feeding. | reception of odorants by two main head appendages, antennae and maxillary palps, is essential for insects' survival and reproduction. there is growing evidence in the literature suggesting that the proboscis is also an olfactory appendage and its function as an additional "antenna" has been previously proposed. we surmised that movements of the labrum toward a blood vessel might be chemically oriented and, if so, there should be odorant receptors expressed in the labrum. to test this hypothesis, ... | 2015 | 26578978 |
| wolbachia and the insect immune system: what reactive oxygen species can tell us about the mechanisms of wolbachia-host interactions. | wolbachia are intracellular bacteria that infect a vast range of arthropod species, making them one of the most prevalent endosymbionts in the world. wolbachia's stunning evolutionary success is mostly due to their reproductive parasitism but also to mutualistic effects such as increased host fecundity or protection against pathogens. however, the mechanisms underlying wolbachia phenotypes, both parasitic and mutualistic, are only poorly understood. moreover, it is unclear how the insect immune ... | 2015 | 26579107 |
| el niño-southern oscillation, local weather and occurrences of dengue virus serotypes. | severe dengue fever is usually associated with secondary infection by a dengue virus (denv) serotype (1 to 4) that is different to the serotype of the primary infection. dengue outbreaks only occur following importations of denv in cairns, australia. however, the majority of imported cases do not result in autochthonous transmission in cairns. although denv transmission is strongly associated with the el niño-southern oscillation (enso) climate cycle and local weather conditions, the frequency a ... | 2015 | 26581295 |
| ixodes scapularis and ixodes ricinus tick cell lines respond to infection with tick-borne encephalitis virus: transcriptomic and proteomic analysis. | ixodid ticks are important vectors of a wide variety of viral, bacterial and protozoan pathogens of medical and veterinary importance. although several studies have elucidated tick responses to bacteria, little is known about the tick response to viruses. to gain insight into the response of tick cells to flavivirus infection, the transcriptomes and proteomes of two ixodes spp cell lines infected with the flavivirus tick-borne encephalitis virus (tbev) were analysed. | 2015 | 26582129 |
| viral interference and persistence in mosquito-borne flaviviruses. | mosquito-borne flaviviruses are important pathogens for humans, and the detection of two or more flaviviruses cocirculating in the same geographic area has often been reported. however, the epidemiological impact remains to be determined. mosquito-borne flaviviruses are primarily transmitted through aedes and culex mosquitoes; these viruses establish a life-long or persistent infection without apparent pathological effects. this establishment requires a balance between virus replication and the ... | 2015 | 26583158 |
| arthropod vectors and disease transmission: translational aspects. | 2015 | 26583380 | |
| insect resistance to bacillus thuringiensis toxin cry2ab is conferred by mutations in an abc transporter subfamily a protein. | the use of conventional chemical insecticides and bacterial toxins to control lepidopteran pests of global agriculture has imposed significant selection pressure leading to the rapid evolution of insecticide resistance. transgenic crops (e.g., cotton) expressing the bt cry toxins are now used world wide to control these pests, including the highly polyphagous and invasive cotton bollworm helicoverpa armigera. since 2004, the cry2ab toxin has become widely used for controlling h. armigera, often ... | 2015 | 26583651 |
| fast evolutionary rates associated with functional loss in class i glucose transporters of schistosoma mansoni. | the trematode parasite, schistosoma mansoni, has evolved to switch from oxidative phosphorylation to glycolysis in the presence of glucose immediately after invading the human host. this metabolic switch is dependent on extracellular glucose concentration. four glucose transporters are encoded in the genome of s. mansoni, however, only two were shown to facilitate glucose diffusion. | 2015 | 26584526 |
| deltamethrin resistance mechanisms in aedes aegypti populations from three french overseas territories worldwide. | aedes aegypti is a cosmopolite mosquito, vector of arboviruses. the worldwide studies of its insecticide resistance have demonstrated a strong loss of susceptibility to pyrethroids, the major class of insecticide used for vector control. french overseas territories such as french guiana (south america), guadeloupe islands (lesser antilles) as well as new caledonia (pacific ocean), have encountered such resistance. | 2015 | 26588076 |
| genomic analysis of detoxification supergene families in the mosquito anopheles sinensis. | anopheles sinensis is an important malaria vector in china and other southeast asian countries, and the emergence of insecticide resistance in this mosquito poses a serious threat to the efficacy of malaria control programs. the recently published an. sinensis genome and transcriptome provide an opportunity to understand the molecular mechanisms of insecticide resistance. analysis of the an. sinensis genome revealed 174 detoxification genes, including 93 cytochrome p450s (p450s), 31 glutathione- ... | 2015 | 26588704 |
| a novel in vitro bioassay to explore the repellent effects of compounds against mosquito aedes aegypti (diptera: culicidae). | mosquitoes are vectors for many pathogens resulting in many deaths of humans. repellents play an important role in reducing mosquito bites and the spread of mosquito-borne diseases. currently, klun & debboun (k & d) and human-arm-based bioassay systems are used to identify repellent properties of compounds, extracts, and essential oils. risks involved with human-arm-based systems are allergic reactions and limited replicates. we are reporting an in vitro bioassay method “ncnpr repellent bioassay ... | 2016 | 26590191 |
| comparison of sampling techniques for rift valley fever virus potential vectors, aedes aegypti and culex pipiens complex, in ngorongoro district in northern tanzania. | we investigated mosquito sampling techniques with two types of traps and attractants at different time for trapping potential vectors for rift valley fever virus. the study was conducted in six villages in ngorongoro district in tanzania from september to october 2012. a total of 1814 mosquitoes were collected, of which 738 were collected by cdc light traps and 1076 by mosquito magnet trapping technique. of the collected mosquitoes, 12.46% (n = 226) were aedes aegypti and 87.54% (n = 1588) were ... | 2013 | 26591704 |
| neuropeptides in the cerebral ganglia of the mud crab, scylla paramamosain: transcriptomic analysis and expression profiles during vitellogenesis. | neuropeptides play a critical role in regulating animal reproduction. in vertebrates, gnrh, gnih and kisspeptin are the key neuropeptide hormones of the reproductive axis, however, the reproductive axis for invertebrates is vague. knowledge on ovarian development of the mud crab, scylla paramamosain, is critical for aquaculture and resources management of the commercially important species. this study employed illumina sequencing, reverse transcription-polymerase chain reaction and quantitative ... | 2015 | 26592767 |
| chikungunya nsp2 protease is not a papain-like cysteine protease and the catalytic dyad cysteine is interchangeable with a proximal serine. | chikungunya virus is the pathogenic alphavirus that causes chikungunya fever in humans. in the last decade millions of cases have been reported around the world from africa to asia to the americas. the alphavirus nsp2 protein is multifunctional and is considered to be pivotal to viral replication, as the nsp2 protease activity is critical for proteolytic processing of the viral polyprotein during replication. classically the alphavirus nsp2 protease is thought to be papain-like with the enzyme r ... | 2015 | 26597768 |
| detection of persistent chikungunya virus rna but not infectious virus in experimental vertical transmission in aedes aegypti from malaysia. | vertical transmission may contribute to the maintenance of arthropod-borne viruses, but its existence in chikungunya virus (chikv) is unclear. experimental vertical transmission of infectious clones of chikv in aedes aegypti mosquitoes from malaysia was investigated. eggs and adult progeny from the second gonotrophic cycles of infected parental mosquitoes were tested. using polymerase chain reaction (pcr), 56.3% of pooled eggs and 10% of adult progeny had detectable chikv rna, but no samples had ... | 2015 | 26598564 |
| plasmodium evasion of mosquito immunity and global malaria transmission: the lock-and-key theory. | plasmodium falciparum malaria originated in africa and became global as humans migrated to other continents. during this journey, parasites encountered new mosquito species, some of them evolutionarily distant from african vectors. we have previously shown that the pfs47 protein allows the parasite to evade the mosquito immune system of anopheles gambiae mosquitoes. here, we investigated the role of pfs47-mediated immune evasion in the adaptation of p. falciparum to evolutionarily distant mosqui ... | 2015 | 26598665 |
| highly efficient cas9-mediated gene drive for population modification of the malaria vector mosquito anopheles stephensi. | genetic engineering technologies can be used both to create transgenic mosquitoes carrying antipathogen effector genes targeting human malaria parasites and to generate gene-drive systems capable of introgressing the genes throughout wild vector populations. we developed a highly effective autonomous clustered regularly interspaced short palindromic repeats (crispr)-associated protein 9 (cas9)-mediated gene-drive system in the asian malaria vector anopheles stephensi, adapted from the mutagenic ... | 2015 | 26598698 |
| purification and characterization of a novel nad(p)+-farnesol dehydrogenase from polygonum minus leaves. | juvenile hormones have attracted attention as safe and selective targets for the design and development of environmentally friendly and biorational insecticides. in the juvenile hormone iii biosynthetic pathway, the enzyme farnesol dehydrogenase catalyzes the oxidation of farnesol to farnesal. in this study, farnesol dehydrogenase was extracted from polygonum minus leaves and purified 204-fold to apparent homogeneity by ion-exchange chromatography using deae-toyopearl, sp-toyopearl, and super-q ... | 2015 | 26600471 |
| trace samples of human blood in mosquitoes as a forensic investigation tool. | investigations of any type of crime invariably starts at the crime scene by collecting evidence. thus, the purpose of this research was to collect and analyze an entomological trace from an environment that is similar to those of indoor crime scenes. hematophagous mosquitoes were collected from two residential units; saliva of volunteers that were residents in the units was also collected for genetic analysis as reference samples. we examined the allele frequencies of 15 short tandem repeat loci ... | 2015 | 26600546 |
| repellant and insecticidal activities of shyobunone and isoshyobunone derived from the essential oil of acorus calamus rhizomes. | it was found that the essential oil of acorus calamus rhizomes showed insecticidal activity. | 0 | 26600710 |
| chikungunya. | chikungunya is an acute viral disease characterised by fever and painful arthralgia. the arthritic symptoms associated with chikungunya can be debilitating and may persist for months or even years in some patients. severe neurological complications such as encephalitis have also been reported during recent large outbreaks. the disease is caused by chikungunya virus (chikv), a mosquito-borne alphavirus from the togaviridae family, which has recently emerged to become one of the most important exo ... | 2015 | 26601450 |
| a genome-scale investigation of incongruence in culicidae mosquitoes. | comparison of individual gene trees in several recent phylogenomic studies from diverse lineages has revealed a surprising amount of topological conflict or incongruence, but we still know relatively little about its distribution across the tree of life. to further our understanding of incongruence, the factors that contribute to it and how it can be ameliorated, we examined its distribution in a clade of 20 culicidae mosquito species through the reconstruction and analysis of the phylogenetic h ... | 2015 | 26608059 |
| mosquito salivary allergen aed a 3: cloning, comprehensive molecular analysis, and clinical evaluation. | allergic reactions to mosquito bites are an increasing clinical concern. due to the lack of availability of mosquito salivary allergens, they are underdiagnosed. here, we reported a newly cloned mosquito aedes (ae.) aegypti salivary allergen. | 2016 | 26608594 |
| natural vertical transmission of dengue viruses in aedes aegypti in selected sites in cebu city, philippines. | we attempted to determine the vertical transmission of dengue virus (denv) in aedes aegypti in selected sites in cebu city, philippines. mosquito sub-adults were collected monthly from households and the field during the wet-dry-wet season from november, 2011 to july, 2012 and were laboratory-reared to adults. viral rna extracts in mosquitoes were assayed by hemi-nested rt-pcr. results showed that 62 (36.26%; n=679) out of 171 mosquito pools (n=2,871) were denv+. the minimum infection rate (mir) ... | 2015 | 26611963 |
| intraspecific variation in desiccation survival time of aedes aegypti (l.) mosquito eggs of australian origin. | aedes aegypti (l.) mosquitoes preferentially oviposit in natural and artificial receptacles where their eggs are able to withstand drying as water levels fluctuate. desiccation-resistant eggs also increase the potential for establishment in non-native habitats while providing logistical impediments to control programs. viability and mean survival times of eggs stored under three dryness conditions for up to 367 days were investigated among three field-derived colonies of australian ae. aegypti t ... | 2015 | 26611964 |
| comparative efficacy of existing surveillance tools for aedes aegypti in western kenya. | all traditional surveillance techniques for aedes aegypti have been developed for the cosmopolitan domestic subspecies ae. aegypti aegypti, and not the sylvatic subspecies, ae. aegypti formosus. the predominant form in western kenya is ae. aegypti formosus that is rarely associated with human habitations but is linked to transmission of sylvatic dengue virus strains. we compared five surveillance methods for their effectiveness in sampling ae. aegypti formosus with the goal of determining a sust ... | 2015 | 26611965 |
| the effects of plant essential oils on escape response and mortality rate of aedes aegypti and anopheles minimus. | the high throughput screening system (hitss) has been applied in insecticide behavioral response studies with various mosquito species. in general, chemical or natural compounds can produce a range of insect responses: contact irritancy, spatial repellency, knock-down, and toxicity. this study characterized these actions in essential oils derived from citronella, hairy basil, catnip, and vetiver in comparison to deet and picaridin against aedes aegypti and anopheles minimus mosquito populations. ... | 2015 | 26611967 |
| new records of aedes aegypti at the southern limit of its distribution in buenos aires province, argentina. | 2015 | 26611978 | |
| dengue-associated acute kidney injury. | dengue is presently the most relevant viral infection transmitted by a mosquito bite that represents a major threat to public health worldwide. acute kidney injury (aki) is a serious and potentially lethal complication of this disease, and the actual incidence is unknown. in this review, we will assess the most relevant epidemiological and clinical data regarding dengue and the available evidence on the frequency, etiopathogenesis, outcomes and treatment of dengue-associated aki. | 2015 | 26613023 |
| sucupira as a potential plant for arthritis treatment and other diseases. | trees of the genus pterodon, commonly known as "sucupira-branca" or "faveira," are native to central brazil. the pterodon fruits are traditionally used in ethnomedicine as an infusion, in small doses, and at regular time intervals as an antirheumatic, anti-inflammatory, tonic, and depurative agent. the various compounds present in the pterodon class are, generally, water-insoluble and derived from the fusion of high-molecular weight pentacarbonate units. scientific research has shown that the ma ... | 2015 | 26613051 |
| sustained efficacy of the novel topical repellent tt-4302 against mosquitoes and ticks. | mosquitoes and ticks are blood-feeding pests of humans and animals that can vector many important aetiological agents of disease. previous research demonstrated that tt-4302 (guardian(®) wilderness) containing 5% geraniol applied to human subjects gave 5-6 h of repellency against mosquitoes (depending on species) and was repellent to ticks in vitro. this study was conducted to obtain an independent third-party evaluation of tt-4302 against stegomyia aegypti (= aedes aegypti) (diptera: culicidae) ... | 2016 | 26614394 |
| chile confronts its environmental health future after 25 years of accelerated growth. | chile has recently been reclassified by the world bank from an upper-middle-income country to a high-income country. there has been great progress in the last 20 to 30 years in relation to air and water pollution in chile. yet after 25 years of unrestrained growth, there remain clear challenges posed by air and water pollution, as well as climate change. | 0 | 26615070 |
| the fucomic potential of mosquitoes: fucosylated n-glycan epitopes and their cognate fucosyltransferases. | fucoconjugates are key mediators of protein-glycan interactions in prokaryotes and eukaryotes. as examples, n-glycans modified with the non-mammalian core α1,3-linked fucose have been detected in various organisms ranging from plants to insects and are immunogenic in mammals. the rabbit polyclonal antibody raised against plant horseradish peroxidase (anti-hrp) is able to recognize the α1,3-linked fucose epitope and is also known to specifically stain neural tissues in the fruit fly drosophila me ... | 2015 | 26617287 |
| screening analogs of β-og pocket binder as fusion inhibitor of dengue virus 2. | dengue is an infectious disease caused by dengue virus (denv) and transmitted between human hosts by mosquitoes. recently, indonesia was listed as a country with the highest cases of dengue by the association of southeast asian nations. the current treatment for dengue disease is supportive therapy; there is no antiviral drug available in the market against dengue. therefore, a research on antiviral drug against dengue is very important, especially to prevent outbreak explosion. in this research ... | 2015 | 26617459 |
| rna-seq de novo assembly reveals differential gene expression in glossina palpalis gambiensis infected with trypanosoma brucei gambiense vs. non-infected and self-cured flies. | trypanosoma brucei gambiense (tbg), causing the sleeping sickness chronic form, completes its developmental cycle within the tsetse fly vector glossina palpalis gambiensis (gpg) before its transmission to humans. within the framework of an anti-vector disease control strategy, a global gene expression profiling of trypanosome infected (susceptible), non-infected, and self-cured (refractory) tsetse flies was performed, on their midguts, to determine differential genes expression resulting from in ... | 2015 | 26617594 |
| increased production of pirnas from euchromatic clusters and genes in anopheles gambiae compared with drosophila melanogaster. | specific genomic loci, termed piwi-interacting rna (pirna) clusters, manufacture pirnas that serve as guides for the inactivation of complementary transposable elements (tes). the pirna pathway has been accurately detailed in drosophila melanogaster, while it remains poorly examined in other insects. this pathway is increasingly recognized as critical for germline development and reproduction. understanding of the pirna functions in mosquitoes could offer an opportunity for disease vector contro ... | 2015 | 26617674 |
| infectious uveitis. | infectious uveitis is one of the most common and visually devastating causes of uveitis in the us and worldwide. this review provides a summary of the identification, treatment, and complications associated with certain forms of viral, bacterial, fungal, helminthic, and parasitic uveitis. in particular, this article reviews the literature on identification and treatment of acute retinal necrosis due to herpes simplex virus, varicella virus, and cytomegalovirus. while no agreed-upon treatment has ... | 2015 | 26618074 |
| towards a hybrid agent-based model for mosquito borne disease. | agent-based models (abm) are used to simulate the spread of infectious disease through a population. detailed human movement, demography, realistic business location networks, and in-host disease progression are available in existing abms, such as the epidemic simulation system (episims). these capabilities make possible the exploration of pharmaceutical and non-pharmaceutical mitigation strategies used to inform the public health community. there is a similar need for the spread of mosquito bor ... | 0 | 26618203 |
| hydrothermal synthesis of titanium dioxide nanoparticles: mosquitocidal potential and anticancer activity on human breast cancer cells (mcf-7). | mosquito vectors (diptera: culicidae) are responsible for transmission of serious diseases worldwide. mosquito control is being enhanced in many areas, but there are significant challenges, including increasing resistance to insecticides and lack of alternative, cost-effective, and eco-friendly products. to deal with these crucial issues, recent emphasis has been placed on plant materials with mosquitocidal properties. furthermore, cancers figure among the leading causes of morbidity and mortali ... | 2016 | 26621285 |
| socio-economic and climate factors associated with dengue fever spatial heterogeneity: a worked example in new caledonia. | understanding the factors underlying the spatio-temporal distribution of infectious diseases provides useful information regarding their prevention and control. dengue fever spatio-temporal patterns result from complex interactions between the virus, the host, and the vector. these interactions can be influenced by environmental conditions. our objectives were to analyse dengue fever spatial distribution over new caledonia during epidemic years, to identify some of the main underlying factors, a ... | 2015 | 26624008 |
| health seeking behaviour and treatment intentions of dengue and fever: a household survey of children and adults in venezuela. | dengue in venezuela is a major public health problem with an increasing incidence of severe cases. early diagnosis and timely treatment influences the outcome of dengue illness, as delay in care-seeking is significantly associated with complications leading to severe dengue. we aimed to understand patterns of health seeking behaviour (hsb) in individuals exposed to high dengue incidence in order to improve early attendance to health centres. | 2015 | 26624283 |
| spatial distribution of epidemiological cases of dengue fever in suriname, 2001-2012. | to characterize the frequency, incidence and severity of dengue fever in suriname and to detect historic clusters of disease by integrating epidemiological data into a spatial visualization platform. | 2015 | 26624585 |
| "salivary gland cellular architecture in the asian malaria vector mosquito anopheles stephensi". | anopheles mosquitoes are vectors for malaria, a disease with continued grave outcomes for human health. transmission of malaria from mosquitoes to humans occurs by parasite passage through the salivary glands (sgs). previous studies of mosquito sg architecture have been limited in scope and detail. | 2015 | 26627194 |
| genome of rhodnius prolixus, an insect vector of chagas disease, reveals unique adaptations to hematophagy and parasite infection. | rhodnius prolixus not only has served as a model organism for the study of insect physiology, but also is a major vector of chagas disease, an illness that affects approximately seven million people worldwide. we sequenced the genome of r. prolixus, generated assembled sequences covering 95% of the genome (∼ 702 mb), including 15,456 putative protein-coding genes, and completed comprehensive genomic analyses of this obligate blood-feeding insect. although immune-deficiency (imd)-mediated immune ... | 2015 | 26627243 |
| aedes aegypti has spatially structured and seasonally stable populations in yogyakarta, indonesia. | dengue fever, the most prevalent global arboviral disease, represents an important public health problem in indonesia. control of dengue relies on the control of its main vector, the mosquito aedes aegypti, yet nothing is known about the population history and genetic structure of this insect in indonesia. our aim was to assess the spatio-temporal population genetic structure of ae. aegypti in yogyakarta, a densely populated region on java with common dengue outbreaks. | 2015 | 26627473 |
| genetic deviation in geographically close populations of the dengue vector aedes aegypti (diptera: culicidae): influence of environmental barriers in south india. | mosquitoes are vectors of devastating pathogens and parasites, causing millions of deaths every year. dengue is a mosquito-borne viral infection found in tropical and subtropical regions around the world. recently, dengue transmission has strongly increased in urban and semiurban areas, becoming a major international public health concern. aedes aegypti (diptera: culicidae) is a primary vector of dengue. shedding light on genetic deviation in a. aegypti populations is of crucial importance to fu ... | 2016 | 26627691 |
| within-species divergence in the seminal fluid proteome and its effect on male and female reproduction in a beetle. | male seminal fluid proteins (sfps), transferred to females during mating, are important reproductive proteins that have multifarious effects on female reproductive physiology and that often show remarkably rapid and divergent evolution. inferences regarding natural selection on sfps are based primarily on interspecific comparative studies, and our understanding of natural within-species variation in sfps and whether this relates to reproductive phenotypes is very limited. here, we introduce an e ... | 2015 | 26627998 |
| self-experimenting physicians: mavericks or martyrs? | 2015 | 26629369 | |
| arbovirus-mosquito interactions: rnai pathway. | arthropod-borne (arbo) viruses infect hematophagous arthropods (vectors) to maintain virus transmission between vertebrate hosts. the mosquito vector actively controls arbovirus infection to minimize its fitness costs. the rna interference (rnai) pathway is the major antiviral response vectors use to restrict arbovirus infections. we know this because depleting rnai gene products profoundly impacts arbovirus replication, the antiviral rnai pathway genes undergo positive, diversifying selection a ... | 2015 | 26629932 |
| consolidating strategic planning and operational frameworks for integrated vector management in eritrea. | contemporary malaria vector control relies on the use of insecticide-based, indoor residual spraying (irs) and long-lasting insecticidal nets (llins). however, malaria-endemic countries, including eritrea, have struggled to effectively deploy these tools due technical and operational challenges, including the selection of insecticide resistance in malaria vectors. this manuscript outlines the processes undertaken in consolidating strategic planning and operational frameworks for vector control t ... | 2015 | 26630934 |
| the interrelationship between dengue incidence and diurnal ranges of temperature and humidity in a sri lankan city and its potential applications. | temperature, humidity, and other weather variables influence dengue transmission. published studies show how the diurnal fluctuations of temperature around different mean temperatures influence dengue transmission. there are no published studies about the correlation between diurnal range of humidity and dengue transmission. | 2015 | 26632645 |
| a venom gland extracellular chitin-binding-like protein from pupal endoparasitoid wasps, pteromalus puparum, selectively binds chitin. | chitin-binding proteins (cbps) are present in many species and they act in a variety of biological processes. we analyzed a pteromalus puparum venom apparatus proteome and transcriptome and identified a partial gene encoding a possible cbp. here, we report cloning a full-length cdna of a sequence encoding a chitin-binding-like protein (ppcbp) from p. puparum, a pupal endoparasitoid of pieris rapae. the cdna encoded a 96-amino-acid protein, including a secretory signal peptide and a chitin-bindin ... | 2015 | 26633500 |
| arbovirus infections. | arbovirus (arthropod-borne virus) infections are increasingly important causes of neurologic disease in the united states through both endemic transmission and travel-associated infections. this article reviews the major arbovirus infections that can cause neurologic disease likely to be encountered in the united states. | 0 | 26633778 |
| oviposition behavior in aedes aegypti and aedes albopictus (diptera: culicidae) in response to the presence of heterospecific and conspecific larvae. | in mosquitoes, location of suitable sites for oviposition requires a set of visual, tactile, and olfactory cues that influences females before laying their eggs. the ability of gravid females to distinguish among potential oviposition sites that will or will not support the growth, development, and survival of their progeny is critical. aedes aegypti (l.) and aedes albopictus (skuse) share ecological niches, being highly competitive in larval stage. we studied the oviposition behavior of both sp ... | 2016 | 26634825 |
| dengue: what it is and why there is more. | in 2014, china experienced the worst outbreak of dengue fever in the last decade with over 40,000 dengue cases including six deaths by the end of october. as one of the "neglected" tropical diseases, dengue is affecting substantially increasing number of people and proportion of global population due to factors including globalization, human settlement, and possibly climate change. here, the authors summarized the most recent data about dengue outbreaks in china and reviewed the global trend of ... | 2015 | 26640300 |
| cloning and functional characterization of two btb genes in the predatory mite metaseiulus occidentalis. | proteins containing the btb (bric-à-brac, tramtrack, and broad complex) domain typically share low sequence similarities and are involved in a wide range of cellular functions. we previously identified two putative and closely related btb genes, btb1 and btb2, in the genome of the predatory mite metaseiulus occidentalis. in the current study, full-length btb1 and btb2 cdnas were cloned and sequenced. btb1 and btb2 encode proteins of 380 and 401 amino acids, respectively. btb1 and btb2 proteins e ... | 2015 | 26640898 |
| molecular differentiation of the african yellow fever vector aedes bromeliae (diptera: culicidae) from its sympatric non-vector sister species, aedes lilii. | yellow fever continues to be a problem in sub-saharan africa with repeated epidemics occurring. the mosquito aedes bromeliae is a major vector of yellow fever, but it cannot be readily differentiated from its non-vector zoophilic sister species ae. lilii using morphological characters. genetic differences have been reported between anthropophilic ae. bromeliae and zoophilic ae. lilii and between forest and domestic populations. however, due to the application of different molecular markers and n ... | 2015 | 26641858 |
| clinical and epidemiological characterization of the first recognized outbreak of dengue virus-type 2 in mozambique, 2014. | since the first reported epidemic of dengue in pemba, the capital of cabo delgado province, in 1984-1985, no further cases have been reported in mozambique. in march 2014, the provincial health directorate of cabo delgado reported a suspected dengue outbreak in pemba, associated with a recent increase in the frequency of patients with nonmalarial febrile illness. an investigation conducted between march and june detected a total of 193 clinically suspected dengue patients in pemba and nampula, t ... | 2016 | 26643534 |
| seroprevalence of asian lineage chikungunya virus infection on saint martin island, 7 months after the 2013 emergence. | at the end of 2013, chikungunya virus (chikv) emerged in saint martin island, caribbean. the asian lineage was identified. seven months after this introduction, the seroprevalence was 16.9% in the population of saint martin and 39.0% of infections remained asymptomatic. this moderate attack rate and the apparent limited size of the outbreak in saint martin could be explained by control measures involved to lower the exposure of the inhabitants. other drivers such as climatic factors and populati ... | 2015 | 26643536 |
| the ancestral gene repertoire of animal stem cells. | stem cells are pivotal for development and tissue homeostasis of multicellular animals, and the quest for a gene toolkit associated with the emergence of stem cells in a common ancestor of all metazoans remains a major challenge for evolutionary biology. we reconstructed the conserved gene repertoire of animal stem cells by transcriptomic profiling of totipotent archeocytes in the demosponge ephydatia fluviatilis and by tracing shared molecular signatures with flatworm and hydra stem cells. phyl ... | 2015 | 26644562 |
| nutritional control of insect reproduction. | the amino acid-target of rapamycin (aa/tor) and insulin pathways play a pivotal role in reproduction of female insects, serving as regulatory checkpoints that guarantee the sufficiency of nutrients for developing eggs. being evolutionary older, the aa/tor pathway functions as an initial nutritional sensor that not only activates nutritional responses in a tissue-specific manner, but is also involved in the control of insect insulin-like peptides (ilps) secretion. insulin and aa/tor pathways also ... | 0 | 26644995 |
| transcriptional cellular responses in midgut tissue of aedes aegypti larvae following intoxication with cry11aa toxin from bacillus thuringiensis. | although much is known about the mechanism of action of bacillus thuringiensis cry toxins, the target tissue cellular responses to toxin activity is less understood. previous transcriptomic studies indicated that significant changes in gene expression occurred during intoxication. however, most of these studies were done in organisms without a sequenced and annotated reference genome. a reference genome and transcriptome is available for the mosquito aedes aegypti, and its importance as a diseas ... | 2015 | 26645277 |
| estimating dengue type reproduction numbers for two provinces of sri lanka during the period 2013-14. | dengue is an endemic disease in the southeast asian country sri lanka. two seasonal peaks of dengue incidence were observed every year since 2002 onwards. in this study, we formulate a 2-strain dengue model for analyzing the monthly seasonal dengue incidence data from 2 provinces of sri lanka during the period april 2013 to september 2014. the seasonality is incorporated in the model in terms of mosquito biting rate, which we assume to be time periodic. we estimated 2 primary reproduction number ... | 2015 | 26646355 |
| accelerated evolution of constraint elements for hematophagic adaptation in mosquitoes. | comparative genomics is a powerful approach that comprehensively interprets the genome. herein, we performed whole genome comparative analysis of 16 diptera genomes, including four mosquitoes and 12 drosophilae. we found more than 540 000 constraint elements (ces) in the diptera genome, with the majority found in the intergenic, coding and intronic regions. accelerated elements (aes) identified in mosquitoes were mostly in the protein-coding regions (>93%), which differs from vertebrates in geno ... | 0 | 26646568 |
| (e)-caryophyllene and α-humulene: aedes aegypti oviposition deterrents elucidated by gas chromatography-electrophysiological assay of commiphora leptophloeos leaf oil. | aedes aegypti is responsible for the transmission of dengue, a disease that infects millions of people each year. although essential oils are well recognized as sources of compounds with repellent and larvicidal activities against the dengue mosquito, much less is known about their oviposition deterrent effects. commiphora leptophloeos, a tree native to south america, has important pharmacological properties, but the chemical profile and applicability of its essential oil in controlling the spre ... | 2015 | 26650757 |
| administration of ivermectin to peridomestic cattle: a promising approach to target the residual transmission of human malaria. | the success of current control tools in combatting malaria vectors is well established. however, sustained residual transmission of plasmodium parasites persists. mass drug administration (mda) to humans of the endectocide ivermectin for vector control is receiving increasing attention. however, vectors feeding upon animals escape this promising approach. zoophagy of mosquitoes sustains both the vector population and endemic population of vector-borne pathogens. therefore, only a strategy that w ... | 2015 | 26651335 |
| genome-wide identification and expression profiling of serine proteases and homologs in the diamondback moth, plutella xylostella (l.). | serine proteases (sps) are crucial proteolytic enzymes responsible for digestion and other processes including signal transduction and immune responses in insects. serine protease homologs (sphs) lack catalytic activity but are involved in innate immunity. this study presents a genome-wide investigation of sps and sphs in the diamondback moth, plutella xylostella (l.), a globally-distributed destructive pest of cruciferous crops. | 2015 | 26653876 |
| nmr structure and function of helicoverpa armigera sterol carrier protein-2, an important insecticidal target from the cotton bollworm. | the cotton bollworm, helicoverpa armigera, has developed strong resistance to many insecticides. sterol carrier protein-2 (scp-2) is an important non-specific lipid transfer protein in insects and appears to be a potential new target. in order to elucidate the structure and function of helicoverpa armigera scp-2 (hascp-2), nmr spectroscopy, docking simulations, mutagenesis and bioassays were performed. hascp-2 composed of five α-helices and four stranded β-sheets. the folds of α-helices and β-sh ... | 2015 | 26655641 |
| only a minority of broad-range detoxification genes respond to a variety of phytotoxins in generalist bemisia tabaci species. | generalist insect can utilize two different modes for regulating their detoxification genes, the constitutive mode and the induced mode. here, we used the bemisia tabaci sibling species meam1 and med, as a model system for studying constitutive and induced detoxification resistance and their associated tradeoffs. b. tabaci adults were allowed to feed through membranes for 24 h on diet containing only sucrose or sucrose with various phytotoxins. quantitative real-time pcr analyses of 18 detoxific ... | 2015 | 26655836 |
| enhanced performance of an innovative dengue igg/igm rapid diagnostic test using an anti-dengue edi monoclonal antibody and dengue virus antigen. | high levels of anti-dengue igm or igg can be detected using numerous rapid diagnostic tests (rdts). however, the sensitivity and specificity of these tests are reduced by changes in envelope glycoprotein antigenicity that inevitably occur in limited expression systems. a novel rdt was designed to enhance diagnostic sensitivity. dengue viruses cultured in animal cells were used as antigens to retain the native viral coat protein. monoclonal antibodies (mabs) were then developed, for the first tim ... | 2015 | 26655854 |
| human social behavior and demography drive patterns of fine-scale dengue transmission in endemic areas of colombia. | dengue is known to transmit between humans and a. aegypti mosquitoes living in neighboring houses. although transmission is thought to be highly heterogeneous in both space and time, little is known about the patterns and drivers of transmission in groups of houses in endemic settings. we carried out surveys of pcr positivity in children residing in 2-block patches of highly endemic cities of colombia. we found high levels of heterogeneity in pcr positivity, varying from less than 30% in 8 of th ... | 2015 | 26656072 |
| knockdown of a nutrient amino acid transporter gene ldnat1 reduces free neutral amino acid contents and impairs leptinotarsa decemlineata pupation. | a leptinotarsa decemlineata slc6 nat gene (ldnat1) was cloned. ldnat1 was highly expressed in the larval alimentary canal especially midgut. ldnat1 mrna levels were high right after the molt and low just before the molt. jh and a jh analog pyriproxyfen activated ldnat1 expression. rnai of an allatostatin gene ldas-c increased jh and upregulated ldnat1 transcription. conversely, silencing of a jh biosynthesis gene ldjhamt decreased jh and reduced ldnat1 expression. moreover, 20e and an ecdysteroi ... | 2015 | 26657797 |
| methoprene-tolerant (met) and krüpple-homologue 1 (kr-h1) are required for ovariole development and egg maturation in the brown plant hopper. | the brown plant hopper is one of the most destructive known pests of rice. we studied the roles of the jh receptor met and the downstream transcription factor kr-h1 in ovariole development and egg maturation. the predicted met protein in n. lugens (nlmet) contained 517 amino acids. qrt-pcr showed that nlmet was expressed in all tissues and that the highest expression occurred in the embryonic stage. in nlmet- or nlkr-h1-silenced female adults, ovarian development varied significantly, whereas th ... | 2015 | 26658174 |
| the drosophila zinc finger transcription factor ouija board controls ecdysteroid biosynthesis through specific regulation of spookier. | steroid hormones are crucial for many biological events in multicellular organisms. in insects, the principal steroid hormones are ecdysteroids, which play essential roles in regulating molting and metamorphosis. during larval and pupal development, ecdysteroids are synthesized in the prothoracic gland (pg) from dietary cholesterol via a series of hydroxylation and oxidation steps. the expression of all but one of the known ecdysteroid biosynthetic enzymes is restricted to the pg, but the transc ... | 2015 | 26658797 |
| coevolution of the ile1,016 and cys1,534 mutations in the voltage gated sodium channel gene of aedes aegypti in mexico. | worldwide the mosquito aedes aegypti (l.) is the principal urban vector of dengue viruses. currently 2.5 billion people are at risk for infection and reduction of ae. aegypti populations is the most effective means to reduce the risk of transmission. pyrethroids are used extensively for adult mosquito control, especially during dengue outbreaks. pyrethroids promote activation and prolong the activation of the voltage gated sodium channel protein (vgsc) by interacting with two distinct pyrethroid ... | 2015 | 26658798 |
| potential applications of insect symbionts in biotechnology. | symbiotic interactions between insects and microorganisms are widespread in nature and are often the source of ecological innovations. in addition to supplementing their host with essential nutrients, microbial symbionts can produce enzymes that help degrade their food source as well as small molecules that defend against pathogens, parasites, and predators. as such, the study of insect ecology and symbiosis represents an important source of chemical compounds and enzymes with potential biotechn ... | 2015 | 26659224 |
| neurotropic virus infections as the cause of immediate and delayed neuropathology. | a wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt the complex structural and functional architecture of the central nervous system, frequently leaving the patient or affected animal with a poor or fatal prognosis. mechanisms that govern neuropathogenes ... | 2015 | 26659576 |