TitleAbstractYear(sorted descending)
evidence for the natural occurrence of wolbachia in aedes aegypti mosquitoes.wolbachia, a gram-negative bacterium, is widely known to be present in arthropods and nematodes. of late, great impetus is given to employ this intracellular bacterium, as an alternative to conventional biocontrol agents for the control of mosquitoes because of its inherent ability to induce sperm-egg incompatibility, feminisation etc. by employing molecular tools, we have shown the presence of wolbachia from aedes aegypti mosquito population collected from coimbatore, india by pcr amplifying th ...201930869785
corrigendum to "larvicidal potential of five selected dragonfly nymphs in sri lanka over aedes aegypti (linnaeus) larvae under laboratory settings".[this corrects the article doi: 10.1155/2018/8759459.].201930868069
first dengue virus seroprevalence study on madeira island after the 2012 outbreak indicates unreported dengue 2012, the first dengue virus outbreak was reported on the portuguese island of madeira with 1080 confirmed cases. dengue virus of serotype 1 (denv-1), probably imported from venezuela, caused this outbreak with autochthonous transmission by invasive aedes aegypti mosquitoes.201930867031
genome-wide divergence among invasive populations of aedes aegypti in the summer of 2013, aedes aegypti linnaeus was first detected in three cities in central california (clovis, madera and menlo park). it has now been detected in multiple locations in central and southern ca as far south as san diego and imperial counties. a number of published reports suggest that ca populations have been established from multiple independent introductions.201930866822
naturally infected aedes aegypti collected during a zika virus outbreak have viral titres consistent with transmission. 201930866777
costs of an aedes aegypti vector control program. 201930864616
larvicidal activity of selected essential oil in synergized combinations against aedes aegypti.this study was conducted to attain an alternate plant essential oil (eo) based mosquito larvicide against the dengue vector aedes aegypti. here three plants were selected based on their local availability, safety and insecticidal properties. eos were extracted from syzygium aromaticum (myrtaceae) flower buds, fruits of illicium verum (schisandraceae) and trachyspermum ammi (apiaceae) by hydro-distillation and tested against ae. aegypti larvae individually and in combinations to find synergistic ...201930861442
global outbreaks and origins of a chikungunya virus variant carrying mutations which may increase fitness for aedes aegypti: revelations from the 2016 mandera, kenya 2016, a chikungunya virus (chikv) outbreak was reported in mandera, kenya. this was the first major chikv outbreak in the country since the global reemergence of this virus in kenya in 2004. we collected samples and sequenced viral genomes from this outbreak. all kenyan genomes contained two mutations, e1:k211e and e2:v264a, recently reported to have an association with increased infectivity, dissemination, and transmission in the aedes aegypti vector. phylogeographic inference of temporal an ...201930860010
aedes aegypti agbr1 antibodies modulate early zika virus infection of mice.a recent epidemic of zika virus in the americas, affecting well over a million people, caused substantial mortality and morbidity, including guillain-barre syndrome, microcephaly and other fetal developmental defects1,2. preventive and therapeutic measures that specifically target the virus are not readily available. the transmission of zika virus is predominantly mosquito-borne, and aedes aegypti mosquitoes serve as a key vector for zika virus3. here, to identify salivary factors that modulate ...201930858571
modeling the impact of sterile males on an aedes aegypti population with optimal control.we use partial differential equations to describe the dynamics of an aedes aegypti mosquito population on an island, and the effects of a sterile male release. the model includes mosquito movement and an allee effect to capture extinction events. we apply optimal control theory to identify the release strategy that eliminates the mosquitoes most rapidly, conditional on a limited availability of sterile males. the optimal solution for a single location is to initially release a substantial number ...201930857942
laboratory evaluation of larvicidal and oviposition deterrent properties of edible plant oils for potential management of aedes aegypti (diptera: culicidae) in drinking water containers.the yellow fever mosquito, aedes aegypti (diptera: culicidae) transmits several devastating arboviruses, including dengue, chikungunya, and zika virus, making development of inexpensive and eco-friendly strategies for its control an urgent priority. we evaluated the lethality of 13 commonly used plant-derived edible oils against late-third instar ae. aegypti and then tested the three most lethal oils for stage-specific differences in lethality. we also examined the effects of the most lethal (he ...201930855084
udp-glycosyltransferase genes and their association and mutations associated with pyrethroid resistance in anopheles sinensis (diptera: culicidae).udp-glycosyltransferase (ugt) is an important biotransformation superfamily of enzymes. they catalyze the transfer of glycosyl residues from activated nucleotide sugars to acceptor hydrophobic molecules, and function in several physiological processes, including detoxification, olfaction, cuticle formation, pigmentation. the diversity, classification, scaffold location, characteristics, phylogenetics, and evolution of the superfamily of genes at whole genome level, and their association and muta ...201930845961
molecular epidemiology and genetic diversity of zika virus from field-caught mosquitoes in various regions of thailand.zika virus (zikv) infection is an emerging and re-emerging arbovirus disease that is transmitted to humans through the bite of infected mosquitoes. zikv infections were first described in thailand in 1954 from the sera of indigenous residents and several travelers returning from thailand in 2014. however, reported cases in thailand have been increasing since 2015 and 2016, and epidemiological information about the vectors of zikv is unclear. we investigated the molecular epidemiology and genetic ...201930845707
updated methods for the production of toxorhynchites rutilus septentrionalis (diptera, culicidae) for use as biocontrol agent against container breeding pest mosquitoes in harris county, texas.the complex biologies of pestiferous mosquito species complicate the development of a single, across the board effective control measure. the use of traditional biological control through predators, parasitoids, and microbes, though part of a multimodal, integrated pest management approach, is scant in current standard mosquito control operations. at this time, traditional, whole organism mosquito biocontrol agents are not commercially available, and if their integration into a release program i ...201930843583
urban and semi-urban mosquitoes of mexico city: a risk for endemic mosquito-borne disease transmission.since past century, vector-borne diseases have been a major public health concern in several states of mexico. however, mexico city continues to be free of endemic mosquito-borne viral diseases. the city is the most important politic and economic state of mexico and one of the most important city of latin america. its subtropical highland climate and high elevation (2240 masl) had historically made the occurrence of aedes species unlikely. however, the presence of other potential disease vectors ...201930840661
activity of additives and their effect in formulations of metarhizium anisopliae s.l. ip 46 against aedes aegypti adults and on post mortem conidiogenesis.oil formulations of entomopathogenic fungi have interest for biological mosquito control.201930836061
epidemiological and clinical characteristics of dengue virus outbreaks in two regions of china, 2014 - 2015.dengue virus (denv), a single-stranded rna virus and flaviviridae family member, is transmitted by aedes aegypti and aedes albopictus mosquitoes. denv causes dengue fever, which may progress to severe dengue. hospital-based surveillance was performed in two chinese regions, guangzhou and xishuangbanna, during the dengue epidemics in 2014 and 2015, respectively. acute-phase serum was obtained from 133 patients with suspected dengue infections during the peak season for dengue cases. viremia level ...201930835769
transcriptome sequencing and analysis of changes associated with insecticide resistance in the dengue mosquito (aedes aegypti) in vietnam.the mosquito aedes aegypti is a transmission vector for dangerous epidemic diseases in humans. insecticides have been used as the most general vector control method in the world. however, ae. aegypti have developed many resistant mechanisms such as reduced neuronal sensitivity to insecticides (target-site resistance), enhanced insecticide metabolism (metabolic resistance), altered transport, sequestration, and other mechanisms. it has become a major problem for vector control programs. transcrip ...201930834881
past and future spread of the arbovirus vectors aedes aegypti and aedes albopictus.the global population at risk from mosquito-borne diseases-including dengue, yellow fever, chikungunya and zika-is expanding in concert with changes in the distribution of two key vectors: aedes aegypti and aedes albopictus. the distribution of these species is largely driven by both human movement and the presence of suitable climate. using statistical mapping techniques, we show that human movement patterns explain the spread of both species in europe and the united states following their intr ...201930833735
discovery and characterization of 2-nitro-5-(4-(phenylsulfonyl)piperazin-1-yl)- n-(pyridin-4-ylmethyl)anilines as novel inhibitors of the aedes aegypti kir1 ( aekir1) channel.mosquito-borne arboviral diseases such as zika, dengue fever, and chikungunya are transmitted to humans by infected adult female aedes aegypti mosquitoes and affect a large portion of the world's population. the kir1 channel in ae. aegypti ( aekir1) is an important ion channel in the functioning of mosquito malpighian (renal) tubules and one that can be manipulated in order to disrupt excretory functions in mosquitoes. we have previously reported the discovery of various scaffolds that are activ ...201930832472
characterization, diversity, and structure-activity relationship study of lipoamino acids from pantoea sp. and synthetic analogues.a biological evaluation of a library of extracts from entomopathogen strains showed that pantoea sp. extract has significant antimicrobial and insecticidal activities. three hydroxyacyl-phenylalanine derivatives were isolated from this strain. their structures were elucidated by a comprehensive analysis of their nmr and ms spectroscopic data. the antimicrobial and insecticidal potencies of these compounds were evaluated, and compound 3 showed 67% mortality against aedes aegypti larvae at a conce ...201930832353
determination by chromatography and cytotoxotoxic and oxidative effects of pyriproxyfen and pyridalyl.pyriproxyfen (ppf) is a larvicide, used to combat the proliferation of aedes aegypti larvae. the objective of this study was to analyze the compounds of pyriproxyfen and pyridalyl (pyl) in a commercial larvicide to analyze the cytotoxic and oxidative effects of ppf and pyl. the toxic potential of ppf and pyl were assessed based on lethal concentration (lc50) in artemia salina, cytotoxicity based on the mitotic index and the chromosomal alterations in allium cepa and the oxidative damage in sacch ...201930831490
effects of methylmercury on mosquito oviposition behavior: maladaptive response to non-toxic exposure.animals can modulate their own exposure to environmental contaminants through behavioral plasticity such as diet and habitat choice. however, it remains unclear if behavior also has cascading effects on contaminant exposure across multiple generations. in insects, oviposition site selection is an important behavior females can use to modify offspring contaminant exposure risk. in this study, we use the yellow fever mosquito, aedes aegypti, to test how methylmercury (mehg) affects oviposition sit ...201930831364
protocols for testing the toxicity of novel insecticidal chemistries to classes of insecticides with novel modes of action are needed to control insecticide resistant populations of mosquitoes that transmit diseases such as zika, dengue and malaria. assays for rapid, high-throughput analyses of unformulated novel chemistries against mosquito larvae and adults are presented. we describe protocols for single point-dose and dose response assays to evaluate the toxicity of small molecule chemistries to the aedes aegypti vector of zika, dengue and yellow fever, the m ...201930829331
a comprehensive assessment of inbreeding and laboratory adaptation in aedes aegypti mosquitoes.modified aedes aegypti mosquitoes reared in laboratories are being released around the world to control wild mosquito populations and the diseases they transmit. several efforts have failed due to poor competitiveness of the released mosquitoes. we hypothesized that colonized mosquito populations could suffer from inbreeding depression and adapt to laboratory conditions, reducing their performance in the field. we established replicate populations of ae. aegypti mosquitoes collected from queensl ...201930828375
the first outbreak of dengue fever in greater darfur, western sudan.dengue virus (denv) is an arthropod-borne virus (arbovirus) transmitted by the aedes mosquitoes, mainly aedes aegypti. dengue fever is a rapidly growing disease with expanding geographical distribution worldwide. we investigated a high number of non-malaria febrile cases reported to health clinics in refugee camps in the five states of darfur between august 2015 and march 2016. the clinical presentation of cases and case definition criteria suggested involvement of one or more arboviral hemorrha ...201930823624
trap location and premises condition influences on aedes aegypti (diptera: culicidae) catches using biogents sentinel traps during a 'rear and release' program: implications for designing surveillance the incidence of arboviral diseases such as dengue, zika, chikungunya, and yellow fever increases globally, controlling their primary vector, aedes aegypti (l.) (diptera: culicidae), is of greater importance than ever before. mosquito control programs rely heavily on effective adult surveillance to ensure methodological efficacy. the biogents sentinel (bgs) trap is the gold standard for surveilling adult aedes mosquitoes and is commonly deployed worldwide, including during modern 'rear and re ...201930817823
efficacy of novel indoor residual spraying methods targeting pyrethroid-resistant aedes aegypti within experimental houses.challenges in maintaining high effectiveness of classic vector control in urban areas has renewed the interest in indoor residual spraying (irs) as a promising approach for aedes-borne disease prevention. while irs has many benefits, application time and intrusive indoor applications make its scalability in urban areas difficult. modifying irs to account for ae. aegypti resting behavior, named targeted irs (tirs, spraying walls below 1.5 m and under furniture) can reduce application time; howeve ...201930817759
socio-ecological factors associated with dengue risk and aedes aegypti presence in the galápagos islands, ecuador.dengue fever is an emerging infectious disease in the galápagos islands of ecuador, with the first cases reported in 2002 and subsequent periodic outbreaks. we report results of a 2014 pilot study conducted in puerto ayora (pa) on santa cruz island, and puerto baquerizo moreno (pb) on san cristobal island. to assess the socio-ecological risk factors associated with dengue and mosquito vector presence at the household level, we conducted 100 household surveys (50 on each island) in neighborhoods ...201930813558
assessment of the effectiveness of bg-sentinel traps baited with co2 and bg-lure for the surveillance of vector mosquitoes in miami-dade county, florida.vector-borne diseases are an increasing issue to public health, endangering billions of people worldwide. controlling vector mosquitoes is widely accepted as the most effective way to prevent vector-borne disease outbreaks. mosquito surveillance is critical for the development of control strategies under the integrated vector management framework. we hypothesize that the effectiveness and reliability of using bg-sentinel traps for the surveillance strongly depend on the bait used to attract mosq ...201930794670
widespread insecticide resistance in aedes aegypti l. from new mexico, u.s.a.aedes aegypti mosquitoes are vectors of a variety of emerging viral pathogens, including yellow fever, dengue, chikungunya, and zika virus. this species has established endemic populations in all cities across southern new mexico sampled to date. presently, control of aedes-borne viruses relies on deployment of insecticides to suppress mosquito populations, but the evolution of insecticide resistance threatens the success of vector control programs. while insecticide resistance is quite common i ...201930794644
high frequencies of f1534c and v1016i kdr mutations and association with pyrethroid resistance in aedes aegypti from somgandé (ouagadougou), burkina faso.resistance to pyrethroid insecticides involving kdr mutations is widespread in aedes aegypti (l.) (diptera: culicidae) and potentially could impact control efforts in endemic countries. dengue cases had been sporadic in burkina faso for over a decade prior to the 2016-2017 outbreak that resulted in 15,074 suspected cases and 36 deaths, mainly in ouagadougou. these outbreaks highlighted the lack of information on numerous aspects of the biology, behaviour and insecticide status of local dengue ve ...201930787670
experimental study on the action of larvicides in aedes aegypti populations collected in the brazilian municipality of itabuna, bahia, under simulated field evaluate, under simulated field conditions, the efficacy of pyriproxyfen (juvenile hormone), novaluron (chitin inhibitor) and spinosad (biolarvicide) in controlling aedes aegypti.201930785572
entomological and virological surveillance for dengue virus in churches in merida, mexico.this study was designed to assess whether churches in endemic dengue districts in merida, mexico provide suitable breeding habitats for mosquitoes and are potential sites for dengue virus (denv) transmission. churches were inspected for immature and adult mosquitoes once every week from november 2015 to october 2016. a total of 10,997 immatures of five species were collected. the most abundant species were aedes aegypti (6,051) and culex quinquefasciatus (3,018). the most common source of immatu ...201930785563
origin and expansion of the mosquito aedes aegypti in madeira island (portugal).historically known as the yellow fever mosquito, aedes aegypti invaded madeira island in 2005 and was the vector of the island's first dengue outbreak in 2012. we have studied genetic variation at 16 microsatellites and two mitochondrial dna genes in temporal samples of madeira island, in order to assess the origin of the invasion and the population structure of this mosquito vector. our results indicated at least two independent colonization events occurred on the island, both having a south am ...201930783149
optimization of irradiation dose to aedes aegypti and ae. albopictus in a sterile insect technique program.the sterile insect technique (sit) may offer a means to control the transmission of mosquito borne diseases. sit involves the release of male insects that have been sterilized by exposure to ionizing radiation. we determined the effects of different doses of radiation on the survival and reproductive capacity of local strains of aedes aegypti and ae. albopictus in southern mexico. the survival of irradiated pupae was invariably greater than 90% and did not differ significantly in either sex for ...201930779779
larvicidal and ovicidal activities of artocarpus blancoi extracts against aedes aegypti.dengue control may be done by targeting its vector. in this study, we used artocarpus blancoi (elm.) merr. (moraceae) leaves, an endemic hematophagous insect repellent as a larvicide and ovicide.201930776315
natural vertical infection by dengue virus serotype 4, zika virus and mayaro virus in aedes (stegomyia) aegypti and aedes (stegomyia) albopictus.vertical transmission to progeny ensures the maintenance of arboviruses in their natural vectors. this mechanism is largely reported for dengue virus (denv) and yellow fever virus (yfv). few studies have addressed this mechanism for zika virus (zikv), mayaro virus (mayv) and other arboviruses. the present study investigated the natural infection rate by arboviruses in 4490 aedes (stegomyia) aegypti and 296 aedes (stegomyia) albopictus (diptera: culicidae) reared from eggs collected with ovitraps ...201930776139
interventions for the control of aedes aegypti in latin america and the caribbean: systematic review and determine the effectiveness and degree of implementation of interventions for the control of aedes aegypti in latin america and the caribbean (lac) as reported in scientific literature.201930771267
juvenile hormone controls ovarian development in female anopheles albimanus mosquitoes.anophelinae mosquitoes are vectors of human malaria, a disease that infects hundreds of millions of people and causes almost 600,000 fatalities annually. despite their medical importance, laboratory studies on key aspects of anophelinae reproductive biology have been limited, and in particular, relatively little is known about the role of juvenile hormone (jh) in the control of female reproduction. the study presented here attempts to fill a gap of knowledge in our understanding of the jh contro ...201930765796
female resistance and harmonic convergence influence male mating success in aedes aegypti.despite the importance of mosquito mating biology to reproductive control strategies, a mechanistic understanding of individual mating interactions is currently lacking. using synchronised high-speed video and audio recordings, we quantified behavioural and acoustic features of mating attempts between tethered female and free-flying male aedes aegypti. in most couplings, males were actively displaced by female kicks in the early phases of the interaction, while flight cessation prior to adoption ...201930765779
surveillance of aedes aegypti indoors and outdoors using autocidal gravid ovitraps in south texas during local transmission of zika virus, 2016 to 2018.the yellow fever mosquito, aedes aegypti, has facilitated the re-emergence of dengue virus (denv) and emergence of chikungunya virus (chikv) and zika virus (zikv) in the americas and the caribbean. the recent transmission of these arboviruses in the continental united states has been limited, to date, to south florida and south texas despite ae. aegypti occurring over a much larger geographical region within the country. the main goal of our study was to provide the first long term longitudinal ...201930763563
potential for sylvatic and urban aedes mosquitoes from senegal to transmit the new emerging dengue serotypes 1, 3 and 4 in west africa.dengue fever (den) is the most common arboviral disease in the world and dengue virus (denv) causes 390 million annual infections around the world, of which 240 million are inapparent and 96 million are symptomatic. during the past decade a changing epidemiological pattern has been observed in africa, with den outbreaks reported in all regions. in senegal, all denv serotypes have been reported. these important changes in the epidemiological profile of den are occurring in a context where there i ...201930759080
exome-wide association of deltamethrin resistance in aedes aegypti from mexico.aedes aegypti is the major vector of a number of arboviruses that cause disease in humans. without vaccines or pharmaceuticals, pyrethroid insecticides remain the major tool for public health protection. pyrethroid resistance is now widespread. replacement substitutions in the voltage-gated sodium channel (vgsc) that reduce the stability of pyrethroid binding account for most of the resistance, but metabolic mechanisms also inactivate pyrethroids. high-throughput sequencing and the a. aegypti l5 ...201930758862
risk of dengue transmission in cocody (abidjan, ivory coast).in recent years, an upsurge of vector-borne diseases has been reported in several parts of the world. among these is dengue fever, the first arbovirus transmitted by mosquitoes of the genus aedes. after the detection of the dengue virus serological types (type 1, 2, and 3) in the health district of cocody-bingerville in ivory coast, entomological investigations were carried out in the city of cocody (host of most cases) to evaluate the risk of transmission of the disease in view of an effective ...201930755798
[effect of attraction of transfluthrin and linalool on the mosquito vector aedes aegypti]. 201930753763
citywide control of aedes aegypti (diptera: culicidae) during the 2016 zika epidemic by integrating community awareness, education, source reduction, larvicides, and mass mosquito trapping.this investigation was initiated to control aedes aegypti and zika virus transmission in caguas city, puerto rico, during the 2016 epidemic using integrated vector management (ivm), which included community awareness and education, source reduction, larviciding, and mass-trapping with autocidal gravid ovitraps (ago). the epidemic peaked in august to october 2016 and waned after april 2017. there was a preintervention period in october/november 2016 and ivm lasted until august 2017. the area unde ...201930753539
quantitative evaluation of the behavioral response to attractant and repellent compounds in anopheles pseudopunctipennis and aedes aegypti (diptera: culicidae) larvae.the mosquito anopheles pseudopunctipennis (theobald) is the principal vector for malaria in latin-america. aedes aegypti (l.) (diptera: culicidae) is the key vector of four important arboviral diseases: dengue, yellow fever, zika, and chikungunya. controlling larval stages to reduce the production of new adult mosquitoes is part of the integrated vector management strategies. however, there are few studies about the olfactory behavior on immature stages of mosquitoes, especially in an. pseudopun ...201930753516
vector competence of biting midges and mosquitoes for shuni virus.shuni virus (shuv) is an orthobunyavirus that belongs to the simbu serogroup. shuv was isolated from diverse species of domesticated animals and wildlife, and is associated with neurological disease, abortions, and congenital malformations. recently, shuv caused outbreaks among ruminants in israel, representing the first incursions outside the african continent. the isolation of shuv from a febrile child in nigeria and seroprevalence among veterinarians in south africa suggests that the virus ma ...201930753187
feasibility of feeding aedes aegypti mosquitoes on dengue virus-infected human volunteers for vector competence studies in iquitos, peru.transmission of dengue virus (denv) from humans to mosquitoes represents a critical component of dengue epidemiology. examinations of this process have generally been hampered by a lack of methods that adequately represent natural acquisition of denv by mosquitoes from humans. in this study, we assessed artificial and natural blood feeding methods based on rates of denv infection and dissemination within mosquitoes for use in a field-based epidemiological cohort study in iquitos, peru.201930753180
bacteria: a novel source for potent mosquito feeding-deterrents.antibiotic and insecticidal bioactivities of the extracellular secondary metabolites produced by entomopathogenic bacteria belonging to genus xenorhabdus have been identified; however, their novel applications such as mosquito feeding-deterrence have not been reported. here, we show that a mixture of compounds isolated from xenorhabdus budapestensis in vitro cultures exhibits potent feeding-deterrent activity against three deadly mosquito vectors: aedes aegypti, anopheles gambiae, and culex pipi ...201930746455
the long and short of hearing in the mosquito aedes aegypti.mating behavior in aedes aegypti mosquitoes occurs mid-air and involves the exchange of auditory signals at close range (millimeters to centimeters) [1-6]. it is widely assumed that this intimate signaling distance reflects short-range auditory sensitivity of their antennal hearing organs to faint flight tones [7, 8]. to the contrary, we show here that male mosquitoes can hear the female's flight tone at surprisingly long distances-from several meters to up to 10 m-and that unrestrained, resting ...201930744970
detection of rna-dependent rna polymerase of hubei reo-like virus 7 by next-generation sequencing in aedes aegypti and culex quinquefasciatus mosquitoes from brazil.advancements in next-generation sequencing and bioinformatics have expanded our knowledge of the diversity of viruses (pathogens and non-pathogens) harbored by mosquitoes. hubei reo-like virus 7 (hrlv 7) was recently detected by the virome analysis of fecal samples from migratory birds in australia. we now report the detection of rna-dependent rna polymerase sequences of hrlv 7 in pools of aedes aegypti and culex quinquefasciatus mosquitoes species from the brazilian amazon forest. phylogenetic ...201930744159
modeling the present and future distribution of arbovirus vectors aedes aegypti and aedes albopictus under climate change scenarios in mainland china.aedes aegypti and aedes albopictus are two important mosquito species which transmit various infectious arbovirus diseases represented mainly by dengue fever. these two species of mosquito have a wide range of distribution and strong transfer capacity. with ongoing global climate change, we are facing an increasing public health threat from the rapid spread of vectors in wider geographical areas. based on observed occurrence records of ae. aegypti and ae. albopictus and high-resolution environme ...201930743113
acceptability of aedes aegypti blood feeding on dengue virus-infected human volunteers for vector competence studies in iquitos, part of a study to investigate drivers of dengue virus (denv) transmission dynamics, this qualitative study explored whether denv-infected residents of iquitos, peru, considered it acceptable (1) to participate in direct mosquito feeding experiments (lab-reared aedes aegypti mosquitoes fed directly on human volunteers) and (2) to provide blood meals indirectly (ae. aegypti fed on blood drawn from participants by venipuncture). twelve focus group discussions (fgds; 94 participants: 82 females ...201930742621
mathematical modeling of dengue epidemic: control methods and vaccination strategies.dengue is, in terms of death and economic cost, one of the most important infectious diseases in the world. so, its mathematical modeling can be a valuable tool to help us to understand the dynamics of the disease and to infer about its spreading by the proposition of control methods. in this paper, control strategies, which aim to eliminate the aedes aegypti mosquito, as well as proposals for the vaccination campaign are evaluated. in our mathematical model, the mechanical control is accomplish ...201930740641
small-molecule agonists of ae. aegypti neuropeptide y receptor block mosquito biting.female aedes aegypti mosquitoes bite humans to obtain blood to develop their eggs. remarkably, their strong attraction to humans is suppressed for days after the blood meal by an unknown mechanism. we investigated a role for neuropeptide y (npy)-related signaling in long-term behavioral suppression and discovered that drugs targeting human npy receptors modulate mosquito host-seeking. in a screen of all 49 predicted ae. aegypti peptide receptors, we identified npy-like receptor 7 (npylr7) as the ...201930735632
the perfect appetizer: a pharmacological strategy for a non-biting possibilities for vector-borne disease control are revealed by duvall et al. (2019), who link host-seeking behavioral modulation in aedes aegypti to neuropeptide y (npy)-like receptor 7. small-molecule screening yields agonist compounds able to activate npylr7 and suppress attraction to hosts.201930735629
loop-mediated isothermal amplification (lamp) for the identification of invasive aedes mosquito species.invasive aedes mosquito species (diptera: culicidae) are of public health concern in europe because they are either recognized or potential vectors of pathogens. loop-mediated isothermal amplification (lamp) is a rapid and simple method for amplifying dna with high specificity and efficiency, with the technique having potential for application in the field, including in high-throughput format. specific lamp assays based on rdna internal transcribed spacers 1 or 2 sequences, considering intraspec ...201930734975
impacts of hurricanes irma and maria on aedes aegypti populations, aquatic habitats, and mosquito infections with dengue, chikungunya, and zika viruses in puerto rico.puerto rico was severely impacted by hurricanes irma and maria in september 2017. the island has been endemic for dengue viruses (denv) and recently suffered epidemics of chikungunya (chikv 2014) and zika (zikv 2016) viruses. although severe storms tend to increase the number of vector and nuisance mosquitoes, we do not know how they influence aedes aegypti populations and arboviral transmission. we compared the abundance of female ae. aegypti in autocidal gravid ovitraps (ago traps), container ...201930963992
publisher correction: past and future spread of the arbovirus vectors aedes aegypti and aedes albopictus.this article was mistakenly not made open access when originally published; this has now been amended, and information about the creative commons attribution 4.0 international license has been added into the 'additional information' section.201930962571
differences in mosquito communities in six cities in oklahoma.vector-borne diseases in the united states have recently increased as a result of the changing nature of vectors, hosts, reservoirs, pathogens, and the ecological and environmental conditions. current information on vector habitats and how mosquito community composition varies across space and time is vital to successful vector-borne disease management. this study characterizes mosquito communities in urban areas of oklahoma, united states, an ecologically diverse region in the southern great pl ...201930950499
vector competence of australian aedes aegypti and aedes albopictus for an epidemic strain of zika virus.recent epidemics of zika virus (zikv) in the pacific and the americas have highlighted its potential as an emerging pathogen of global importance. both aedes (ae.) aegypti and ae. albopictus are known to transmit zikv but variable vector competence has been observed between mosquito populations from different geographical regions and different virus strains. since australia remains at risk of zikv introduction, we evaluated the vector competence of local ae. aegypti and ae. albopictus for a braz ...201930946747
linking water quality to aedes aegypti and zika in flood-prone neighborhoods.the ability of ecosystems to regulate water quality and flood events has been linked to health outcomes, including mosquito-borne illnesses. in the san juan bay estuary watershed of puerto rico, habitat alterations and land-use development have disrupted watershed hydrology, exacerbating wastewater discharges and subjecting some neighborhoods to frequent flooding events. in 2016, the mosquito-borne illness zika became a new cause for concern. we hypothesized that nutrient-enriched flood water co ...201930945160
interpreting mosquito feeding patterns in australia through an ecological lens: an analysis of blood meal studies.mosquito-borne pathogens contribute significantly to the global burden of disease, infecting millions of people each year. mosquito feeding is critical to the transmission dynamics of pathogens, and thus it is important to understanding and interpreting mosquito feeding patterns. in this paper we explore mosquito feeding patterns and their implications for disease ecology through a meta-analysis of published blood meal results collected across australia from more than 12,000 blood meals from 22 ...201930944025
v1016g point mutation: the key mutation in the voltage-gated sodium channel (vgsc) gene of pyrethroid-resistant aedes aegypti (diptera: culicidae) in indonesia.resistance to pyrethroid insecticides is widespread in indonesian aedes aegypti (linnaeus), the primary vector of dengue viruses. this study aims to investigate the mutations in the voltage-gated sodium channel (vgsc) conferring pyrethroid resistance against ae. aegypti populations from indonesia. molecular genotyping of mutations using polymerase chain reaction assay and direct dna sequencing were performed at positions 989 and 1,016 in iis6 region, and 1,534 in iiis6 region of the voltage-gate ...201930942885
influence of strategic points in the dispersion of aedes aegypti in infested evaluate whether sites with large amount of potential breeding sites for immature forms of aedes aegypti, called strategic points, influence in the active vector's dispersion into properties in their surroundings.201930942271
detrimental effects of induced antibodies on aedes aegypti reproduction.aedes aegypti (linnaeus) (diptera: culicidae) is the main vector of viruses causing dengue, chikungunya, zika, and yellow fever, worldwide. this report focuses on immuno-blocking four critical proteins in the female mosquito when fed on blood containing antibodies against ferritin, transferrin, one amino acid transporter (naat1), and acetylcholinesterase (ache). peptides from these proteins were selected, synthetized, conjugated to carrier proteins, and used as antigens to immunize new zealand r ...201930941675
correction to: complete nmr chemical shift assignments of odorant binding protein 22 from the yellow fever mosquito, aedes aegypti, bound to arachidonic acid.the article listed above was initially published with incorrect copyright information. upon publication of this correction, the copyright of the article is changed to "the author(s)". the original article has been corrected.201930941584
glycoprotein hormone receptor knockdown leads to reduced reproductive success in male aedes aegypti.glycoprotein hormone receptors mediate a diverse range of physiological functions in vertebrate and invertebrate organisms. the heterodimeric glycoprotein hormone gpa2/gpb5 and its receptor lgr1, constitute a recently discovered invertebrate neuroendocrine signaling system that remains to be functionally characterized. we previously reported that lgr1 is expressed in the testes of adult aedes aegypti mosquitoes, where its immunoreactivity is particularly regionalized. here, we show that lgr1 imm ...201930941056
enhanced mosquitocidal efficacy of colloidal dispersion of pyrethroid nanometric emulsion with benignity towards non-target species.the rising threat of vector-borne diseases and environmental pollution has instigated the investigation of nanotechnology-based applications. the current study deals with a nanotechnological application involving the usage of nanometric pesticides such as permethrin nanoemulsion. the mean droplet diameter and zeta potential of the prepared permethrin nanoemulsion were found to be 12.4 ± 1.13 nm and -20.4 ± 0.56 mv, respectively. the temporal stability of permethrin nanoemulsion was found to be 4 ...201930939406
endogenous non-retroviral elements in genomes of aedes mosquitoes and vector competence.recent extensive (re)emergences of arthropod-borne viruses (arboviruses) such as chikungunya (chikv), zika (zikv) and dengue (denv) viruses highlight the role of the epidemic vectors, aedes aegypti and aedes albopictus, in their spreading. differences of vector competence to arboviruses highlight different virus/vector interactions. while both are highly competent to transmit chikv (alphavirus,togaviridae), only ae. albopictus is considered as a secondary vector for denv (flavivirus, flavivirida ...201930938223
larvicidal, histopathological, antibacterial activity of indigenous fungus penicillium sp. against aedes aegypti l and culex quinquefasciatus (say) (diptera: culicidae) and its acetylcholinesterase inhibition and toxicity assessment of zebrafish (danio rerio).fungal metabolites are considered to be most efficient tools to overcome the issues related to insecticide resistance and environmental pollution. the present study focus on the evaluation of the mosquito larvicidal efficacy of metabolites of seven indigenous fungal isolates (penicillium sp. aspergillus niger, a. flavus, a. parasiticus, rhizopus sp. mucor sp. and aspergillus sp.) on the larvae of aedes aegypti and culex quinquefasciatus under the laboratory condition. the preliminary screening o ...201930936853
local transmission of zika virus in miami-dade county: the florida department of health rises to the early as 2015, florida and centers for disease control and prevention (cdc) public health officials recognized the potential danger of zika for us residents and visitors. the zika virus, a mosquito-borne flavivirus, is transmitted through the bite of the aedes aegypti mosquito. a physician in miami-dade notified the florida department of health (doh) of the first non-travel-related zika case in the united states. a 23-year old pregnant woman had presented on july 7, 2016, at 23 weeks of gesta ...201930933006
aedes aegypti mosquitoes detect acidic volatiles found in human odor using the ir8a pathway.mosquitoes use olfaction as a primary means of detecting their hosts. previously, the functional ablation of a family of aedes aegypti olfactory receptors, the odorant receptors (ors), was not sufficient to reduce host seeking in the presence of carbon dioxide (co2). this suggests the olfactory receptors that remain, such as the ionotropic receptors (irs), could play a significant role in host detection. to test this, we disrupted the ir8a co-receptor in ae. aegypti using crispr/cas9. we found t ...201930930038
evaluation of toxicity and environmental safety in use of spinosad to rationalize control strategies against aedes aegypti.spinosad is a naturally-occurring insecticide used for the management of ae. aegypti larvae. the assessment of ecotoxicological parameters of spinosad is required for verifying the environmentally-friendly behavior of the compound and for evaluating toxicity values on non-target species. thus, the aim of the study was to conduct toxicity tests using daphnia magna as model organism after exposure to different concentrations of spinosad. immobility effects were observed in both acute and chronic t ...201930927668
preliminary screening of mosquito spatial distribution in togo: with special focus on the aedes (diptera: culicidae) species.the togolese republic has a tropical and humid climate which constitutes an ideal environment for mosquitoes to breed and transmit diseases. the aedes mosquito is known to transmit yellow fever (yf), dengue, chikungunya, and zika viruses in west africa. togo has been suffering from yf virus transmission, despite vaccination efforts. unfortunately, there is scarcity in the data that reflect mosquito spatial distribution in togo, specifically possible yf vectors. in the current study, mosquito sur ...201930927005
voltage-gated sodium channel intron polymorphism and four mutations comprise six haplotypes in an aedes aegypti population in taiwan.knockdown resistance (kdr) to dichlorodiphenyltrichloroethane (ddt) and pyrethroids is known to link amino acid substitutions in the voltage-gated sodium channel (vgsc) in aedes aegypti. dengue fever primarily transmitted by ae. aegypti is an annual public health issue in taiwan. accordingly, pyrethroid insecticides have been heavily used for decades to control mosquito populations in the summer and autumn. in taiwan, an ae. aegypti population with two vgsc mutations, v1016g and d1763y, was desc ...201930925149
the electronic song "scary monsters and nice sprites" reduces host attack and mating success in the dengue vector aedes aegypti.sound and its reception are crucial for reproduction, survival, and population maintenance of many animals. in insects, low-frequency vibrations facilitate sexual interactions, whereas noise disrupts the perception of signals from conspecifics and hosts. despite evidence that mosquitoes respond to sound frequencies beyond fundamental ranges, including songs, and that males and females need to struggle to harmonize their flight tones, the behavioral impacts of music as control targets remain unex ...201930922800
use of mechanical and behavioural methods to eliminate female aedes aegypti and aedes albopictus for sterile insect technique and incompatible insect technique separation of mosquitoes at different stages is currently being attempted to ensure the successful release of male mosquitoes in novel vector control approaches. mechanical and behavioral techniques have been tried most frequently.201930922368
investigating the probability of establishment of zika virus and detection through mosquito surveillance under different temperature conditions.because of the increasing threat that zika virus (zikv) poses to more sub-tropical area due to increased global travel, there is a need for better understanding of the effect(s) of temperature on the establishment potential of zikv within these subtropical, temperate, and/or seasonal ae. aegypti populations. the first step to determining risk establishment of zikv in these regions is to assess zikv's ability to infect mosquitoes at less tropical temperatures, and thus be detected through common ...201930921386
global expansion and redistribution of aedes-borne virus transmission risk with climate change.forecasting the impacts of climate change on aedes-borne viruses-especially dengue, chikungunya, and zika-is a key component of public health preparedness. we apply an empirically parameterized model of viral transmission by the vectors aedes aegypti and ae. albopictus, as a function of temperature, to predict cumulative monthly global transmission risk in current climates, and compare them with projected risk in 2050 and 2080 based on general circulation models (gcms). our results show that if ...201930921321
modelling the potential distribution of arbovirus vector aedes aegypti under current and future climate scenarios in taiwan, china.aedes aegypti is one of the most important mosquito species and is a common disease-transmitting pest in tropical areas. various infectious arbovirus diseases can be transmitted by ae. aegypti. with ongoing global climate change, we are facing an increasing public health threat from the rapid spread of disease vectors into wider geographical areas. to better understand the current ecological niche range and possible future expansion of ae. aegypti, an ecological niche modelling approach was adop ...201930919547
genome sequences of chikungunya virus isolates circulating in midwestern brazil.chikungunya virus (chikv) is a reemerging arbovirus of the family togaviridae that causes chikv fever, a disease that can extend from weeks to years depending on whether clinical signs of arthralgia persist. chikv is mainly transmitted by aedes aegypti mosquitoes and possibly reached the americas in 2013, causing an outbreak in brazil in 2015. so far, two evolutionary lineages of chikv have been reported in brazil: the asian and the east-central-south african (ecsa) lineages. in this study, six ...201930729309
repellency assessment of nepeta cataria essential oils and isolated nepetalactones on aedes aegypti.there is an increased need for improved and affordable insect repellents to reduce transmission of rapidly spreading diseases with high mortality rates. natural products are often used when deet cannot be afforded or accessed and when consumers choose not to use a synthetic repellent. the essential oils from two newly bred nepeta cataria (catnip) plants representing two different chemotypes and their respective isolated nepetalactone isomers were evaluated as mosquito repellents against aedes ae ...201930728370
engineered resistance to zika virus in transgenic aedes aegypti expressing a polycistronic cluster of synthetic small rnas.recent zika virus (zikv) outbreaks have highlighted the necessity for development of novel vector control strategies to combat arboviral transmission, including genetic versions of the sterile insect technique, artificial infection with wolbachia to reduce population size and/or vectoring competency, and gene drive-based methods. here, we describe the development of mosquitoes synthetically engineered to impede vector competence to zikv. we demonstrate that a polycistronic cluster of engineered ...201930723148
genotoxic and mutagenic assessment of spinosad using bioassays with tradescantia pallida and drosophila melanogaster.spinosad (spn) is a naturally-occurring insecticide obtained from the fermentation process of the actinomycete saccharopolyspora spinosa. owing to the larvicidal action, the compound has been used in the control of aedes aegypti. as a new insecticide commercially available in the market, few data are reported on genotoxic effects in non-target organisms. the objective of the present study was to evaluate the mutagenic effect of spn through the micronucleus test in tradescantia pallida (trad-mcn) ...201930721808
assessment of acute toxicity and cytotoxicity of fluorescent markers produced by cardanol and glycerol, which are industrial waste, to different biological models.the amphyphylic triazoanilines recently synthesized 1-(4-(3-aminophenyl)-1h-1,2,3- triazole-1-yl)-3-(3-pentadecylphenoxy)propan-2-ol (1) and 1-(4-(4-aminophenyl)-1h- 1,2,3-triazole-1-yl)-3-(3-pentadecylphenoxy)propan-2-ol (2), synthesized from cardanol and glycerol, have photophysical properties which allow their use in the development of fluorescent biomarkers with applicability in the biodiesel quality control. based on this, the present research evaluated the toxic effects of both compounds i ...201930719661
evaluation of enhanced oviposition attractant formulations against aedes and culex vector mosquitoes in urban and semi-urban areas.surveillance is not only an important tool to assess the population dynamics of vector mosquitoes, but it can also be used to control vector-borne diseases. mosquito vectors that belong to several genera such as anopheles, aedes, and culex play a crucial role in the transmission of malaria, dengue, chikungunya, zika, and elephantiasis diseases worldwide. we tested the efficacy of two commercial-grade oviposition attractant formulations that were developed for the container-inhabiting aedes aegyp ...201930719534
homologs of human dengue-resistance genes, fkbp1b and atcay, confer antiviral resistance in aedes aegypti mosquitoes.dengue virus (denv) is transmitted by mosquitoes and is a major public health concern. the study of innate mosquito defense mechanisms against denv have revealed crucial roles for the toll, imd, jak-stat, and rnai pathways in mediating denv in the mosquito. often overlooked in such studies is the role of intrinsic cellular defense mechanisms that we hypothesize to work in concert with the classical immune pathways to affect organismal defense. our understanding of the molecular interaction of de ...201930717390
attraction of female aedes aegypti (l.) to aphid honeydew.plant sugar is an essential dietary constituent for mosquitoes, and hemipteran honeydew is one of the many forms of plant sugar that is important to mosquitoes. many insects rely on volatile honeydew semiochemicals to locate aphids or honeydew itself. mosquitoes exploit volatile semiochemicals to locate sources of plant sugar but their attraction to honeydew has not previously been investigated. here, we report the attraction of female yellow fever mosquitoes, aedes aegypti, to honeydew odorants ...201930717169
analysis of salivary glands and saliva from aedes albopictus and aedes aegypti infected with chikungunya viruses.chikungunya virus (chikv) is a medically important mosquito-borne virus transmitted to humans by infected aedes (stegomyia) species. in 2013⁻2014, ae. aegypti transmitted chikv to humans in the caribbean and in 2005⁻2006, ae. albopictus transmitted chikv on la réunion island (indian ocean basin). chikv lr2006 opy1 from the la réunion epidemic was associated with a mutation (e1:a226v) in the viral e1 glycoprotein that enhanced chikv transmission by ae. albopictus. chikv r99659 from the caribbean ...201930717086
water-induced strong protection against acute exposure to low subzero temperature of adult aedes an important vector of dengue and zika, aedes albopictus has been the fastest spreading invasive mosquitoes in the world over the last 3-4 decades. cold tolerance is important for survival and expansion of insects. ae. albopictus adults are generally considered to be cold-intolerant that cannot survive at subzero temperature. however, we found that ae. albopictus could survive for several hours' exposure to -9 to -19 oc so long as it was exposed with water. median lethal time (lt50) of ae. al ...201930716071
pyrethroids use: threats on metabolic-mediated resistance mechanisms in the primary dengue vector aedes aegypti (diptera: culicidae).the emergence of pyrethroid resistance in aedes aegypti (l.) has limited the success of vector control. early detection of resistance could assist authorities in deciding well-suited control strategies to minimize operational failures of ae. aegypti control. herein, biochemical analysis was performed to investigate the mechanisms involved in pyrethroid resistance in nine populations of indonesian ae. aegypti. enzymes of adult ae. aegypti such as esterases (ests), glutathione-s-transferases (gsts ...201930715464
transcriptional profile of aedes aegypti leucine-rich repeat proteins in response to zika and chikungunya viruses.aedes aegypti (l.) is the primary vector of chikungunya, dengue, yellow fever, and zika viruses. the leucine-rich repeats (lrr)-containing domain is evolutionarily conserved in many proteins associated with innate immunity in invertebrates and vertebrates, as well as plants. we focused on the aaelrim1 and aaeapl1 gene expressions in response to zika virus (zikv) and chikungunya virus (chikv) infection using a time course study, as well as the developmental expressions in the eggs, larvae, pupae, ...201930708982
glycosaminoglycan compositional analysis of relevant tissues in zika virus pathogenesis and in vitro evaluation of heparin as an antiviral against zika virus infection.zika virus (zikv) is an enveloped rna virus from the flavivirus family that can cause fetal neural abnormalities in pregnant women. previously, we established that zikv-ep (envelope protein) binds to human placental chondroitin sulfate (cs), suggesting that cs may be a potential host cell surface receptor in zikv pathogenesis. in this study, we further characterized the gag disaccharide composition of other biological tissues (i.e., mosquitoes, fetal brain cells, and eye tissues) in zikv pathoge ...201930698412
presence of the point mutations val1016gly in the voltage-gated sodium channel detected in a single mosquito from panama, arboviroses such as dengue fever, and more recently chikungunya fever and zika disease, are transmitted by aedes aegypti and aedes albopictus. their control is based on the elimination of breeding sites and fogging with pyrethroid insecticides. however, one of the significant issues derived from the prolonged use of pyrethroid insecticide is the development of resistance mechanisms, such as knockdown resistance or kdr. the objective of this study was to evaluate the presence of kdr mu ...201930691518
identification of potential inhibitors from pyriproxyfen with insecticidal activity by virtual screening.aedes aegypti is the main vector of dengue fever transmission, yellow fever, zika, and chikungunya in tropical and subtropical regions and it is considered to cause health risks to millions of people in the world. in this study, we search to obtain new molecules with insecticidal potential against ae. aegypti via virtual screening. pyriproxyfen was chosen as a template compound to search molecules in the database zinc_natural_stock (znst) with structural similarity using rocs (rapid overlay of c ...201930691028
factors affecting short-range host-seeking for the yellow fever mosquito (diptera: culicidae).understanding short-range cues (e.g., host odorants, heat, moisture) of host-seeking female aedes aegypti l. is very important for attempts to reduce mosquito bites, to complement current control strategies, and to develop potential spatial repellents. we investigated behavior under semi-field conditions utilizing a new portable uni-port taxis box with a caged chicken host. the combined influences of airflow regimes (0, 1.5, 3, 5, and 6 m/s), distance from host odor (10, 50, 100 cm), host-odor c ...201930689913
predation on eggs of aedes aegypti (diptera: culicidae): temporal dynamics and identification of potential predators during the winter season in a temperate temperate regions, the populations of aedes aegypti (l.) remain in the egg stage during the cold season. the ability of these eggs to survive until the next favorable season is affected by several mortality factors, including the action of predators. in the present study, we analyzed the temporal dynamics of the loss of eggs and identified predators of ae. aegypti eggs along the unfavorable season in a temperate region of argentina. to this end, eggs were exposed in field conditions in pitfal ...201930689912
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