Publications

analogs of ldl receptor ligand motifs in dengue envelope and capsid proteins as potential codes for cell entry.	it is established that cell entry of low density lipoprotein particles (llps) containing apo b100 and apo e is mediated by receptors and gags. receptor ligand motifs, xbbbxxbx, xbbxbx, and ψbψxb, and mono- and bipartite nls sequences are abundant in apo e and apo b100 as well as in envelope and capsid proteins of dengue viruses 1-4 (denv1-4). synthetic, fluorescence-labeled peptides of sequences in denv2 envelope protein, and denv3 capsid that include these motifs were used to conduct a qualitat ...	27123468
dengue and its effects on liver.	dengue has emerged as an important arboviral disease with significant impact on the disease burden in population residing in tropical countries. dengue is spread by the bite of aedes mosquito. the virus seems to have some hepatotoxic effects. affliction of liver in form of derangements in the liver function tests is common and may include mild elevations in serum bilirubin, elevated transaminases and derangements in serum albumin. although asymptomatic in most cases, clinical manifestations like ...	25685758
dengue virus specific dual hla binding t cell epitopes induce cd8+ t cell responses in seropositive individuals.	dengue virus infects an estimated 300 million people each year and even more are at risk of becoming infected as the virus continues to spread into new areas. despite the increase in viral prevalence, no anti-viral medications or vaccines are approved for treating or preventing infection. cd8+ t cell responses play a major role in viral clearance. therefore, effective vaccines that induce a broad, multi-functional t cell response with substantial cross-reactivity between all virus serotypes can ...	25668665
el niño southern oscillation and vegetation dynamics as predictors of dengue fever cases in costa rica.	dengue fever (df) and dengue hemorrhagic fever (dhf) are growing health concerns throughout latin america and the caribbean. this study focuses on costa rica, which experienced over 100 000 cases of df/dhf from 2003 to 2007. we utilized data on sea-surface temperature anomalies related to the el niño southern oscillation (enso) and two vegetation indices derived from the moderate resolution imaging spectrometer (modis) from the terra satellite to model the influence of climate and vegetation dyn ...	19763186
reconstructing historical changes in the force of infection of dengue fever in singapore: implications for surveillance and control.	to reconstruct the historical changes in force of dengue infection in singapore, and to better understand the relationship between control of aedes mosquitoes and incidence of classic dengue fever.	18368205
dengue fever presenting as acute pancreatitis.	a 56-year-old non-alcoholic male was admitted with complaints of severe abdominal pain and was diagnosed with acute pancreatitis after blood investigations and a computed tomography scan of the abdomen. he developed a high-grade fever on the third day of admission, and serology tested positive for dengue. treatment for dengue was instituted, leading to a good response and complete resolution of pancreatitis. the patient has been doing well and has had no recurrence of pancreatitis at the end of ...	25610147
study of seroprevalence of dengue fever in central india.		21278875
observation on dengue cases from a virus diagnostic laboratory of a tertiary care hospital in north india.	the epidemiology of dengue fever (df) is complex in the indian subcontinent as all the four serotypes are circulating. this study reports observations on dengue cases from a virus diagnostic laboratory of a north indian tertiary care hospital catering to areas in and around lucknow, uttar pradesh.	26905245
dengue: an escalating problem.		12089096
rnai: antiviral therapy against dengue virus.	dengue virus infection has become a global threat affecting around 100 countries in the world. currently, there is no licensed antiviral agent available against dengue. thus, there is a strong need to develop therapeutic strategies that can tackle this life threatening disease. rna interference is an important and effective gene silencing process which degrades targeted rna by a sequence specific process. several studies have been conducted during the last decade to evaluate the efficiency of si ...	23620845
evasion of the human innate immune system by dengue virus.	dengue virus is a worldwide health problem, with billions of people at risk annually. dengue virus causes a spectrum of diseases, namely dengue fever, dengue hemorrhagic fever and dengue shock syndrome with the latter two being linked to death. understanding how dengue is able to evade the immune system and cause enhanced severity of disease is the main topics of interest in the fernandez-sesma laboratory at mount sinai school of medicine. using primary human immune cells, our group investigates ...	22569913
oral presentation in dengue hemorrhagic fever: a rare entity.	one of the major health hazards which is prevalent and dangerous is the dengue fever which causes the death of many people. this may be associated with a variety of mucocutaneous manifestations which may be of help in early diagnosis. many biochemical assays and hematological investigations may aid in the further diagnosis and treatment of the fatal disease. oral lesions are rare to occur and if present, are often mistaken for platelet abnormality. this case report highlights the importance of o ...	23633881
dengue outbreaks in high-income area, kaohsiung city, taiwan, 2003-2009.	kaohsiung city, a modern metropolis of 1.5 million persons, has been the focus of dengue virus activity in taiwan for several decades. the aim of this study was to provide a temporal and spatial description of dengue virus epidemiology in kaohsiung city by using data for all laboratory-confirmed dengue cases during 2003-2009. we investigated age- and sex-dependent incidence rates and the spatiotemporal patterns of all cases confirmed through passive or active surveillance. elderly persons were a ...	23017369
dengue shock.	shock syndrome is a dangerous complication of dengue infection and is associated with high mortality. severe dengue occurs as a result of secondary infection with a different virus serotype. increased vascular permeability, together with myocardial dysfunction and dehydration, contribute to the development of shock, with resultant multiorgan failure. the onset of shock in dengue can be dramatic, and its progression relentless. the pathogenesis of shock in dengue is complex. it is known that endo ...	21633580
dengue in india.	dengue virus belongs to family flaviviridae, having four serotypes that spread by the bite of infected aedes mosquitoes. it causes a wide spectrum of illness from mild asymptomatic illness to severe fatal dengue haemorrhagic fever/dengue shock syndrome (dhf/dss). approximately 2.5 billion people live in dengue-risk regions with about 100 million new cases each year worldwide. the cumulative dengue diseases burden has attained an unprecedented proportion in recent times with sharp increase in the ...	23041731
seroprevalence and trend of dengue cases admitted to a government hospital, delhi - 5-year study (2006-2010): a look into the age shift.	diagnosis of dengue infection is easily and best accomplished by demonstration of specific igm antibodies in blood. we analyzed retrospectively the dengue igm seropositivity available for samples obtained over a period of 5 years (2006-2010) from patients with suspected dengue fever (df)-like illness to investigate whether there was an overall increase in the dengue igm prevalence over this period.	22973483
molecular characterization and phylogenetic analysis of dengue viruses imported into taiwan during 2008-2010.	we present our surveillance results on imported dengue cases in taiwan during 2008-2010. a total of 734 imported dengue patients were identified. the travelers were arriving from 18 countries, including southeast asia, the indian subcontinent, south pacific islands, and latin america. gene sequences from 358 dengue virus (denv) isolates were used to perform phylogenetic analyses, thus, providing an updated view of the geographic distribution and dynamic transmission of denv strains circulating i ...	22855770
dengue outbreak in hadramout, yemen, 2010: an epidemiological perspective.	we analyzed surveillance data of a dengue outbreak (2010) reported to the hadramout health office (yemen) and retrospectively analyzed dengue-related epidemiological and entomological events reported in hadramout from 2005 to 2009. a total of 630 immunoglobulin m (igm) -confirmed dengue cases of 982 febrile cases was reported during the period from february to june of 2010; 12 cases died, giving case fatality a rate of 1.9%. among febrile cases, the highest proportion of dengue cases (37.3%) was ...	22665621
dispersal of male aedes aegypti in a coastal village in southern mexico.	most aedes aegypti dispersal studies have focused on females because of their central role in dengue virus transmission. only a few mark-release-recapture (mrr) studies provided insights into male ae. aegypti dispersal. to fill this knowledge gap, we conducted five male ae. aegypti mrr experiments in a coastal village in southern mexico. small and large male cohorts were marked with fluorescent dusts, released outside buildings, and recaptures were carried out by using backpack aspirators. recap ...	22492152
dengue hemorrhagic fever in trinidad and tobago: a case for a conservative approach to platelet transfusion.	dengue fever is endemic to trinidad and tobago. a retrospective analysis of all adult admissions at a tertiary hospital in trinidad treated for dengue during january 1-december 31, 2008 was performed. a total of 186 patients were treated during this period: 98.9% (184) of the patients were thrombocytopenic; 45.2% were severely thrombocytopenic; 13 patients showed development of minor hemorrhage and only one case of major hemorrhage; platelet transfusion was given for 7% (13) of the cases; and 6 ...	22403331
impact of insect salivary proteins in blood feeding, host immunity, disease, and in the development of biomarkers for vector exposure.	functional genomic approaches based on expression of recombinant proteins linked to biochemical and disease model approaches resulted in the discovery of novel biological activities and the role some of these proteins play in disease transmission. importantly, the expression of salivary proteins was recently shown to be affected by environmental factors and by the presence of the pathogen in the salivary gland. a practical application resulting from insect saliva research is the use of insect an ...	26339571
molecular insight into dengue virus pathogenesis and its implications for disease control.	dengue virus (denv) is a mosquito-transmitted rna virus that infects an estimated 390 million humans each year. here, we review recent advances in our understanding of the biology of denv and describe knowledge gaps that have impacted the development of effective vaccines and therapeutics.	26232221
clinical and laboratory profile of dengue in the elderly.	dengue is the most rapidly spreading mosquito-borne viral disease in the world with a 30-fold increase in incidence in the last 50 years. approximately, 50 million dengue infections occur annually.	26288776
dengue hemorrhagic fever at 60 years: early evolution of concepts of causation and treatment.	during the decade of the 1960s, the epidemiology of a new dengue disease, dengue hemorrhagic fever and dengue shock syndrome (dhf/dss), was described by collaborative research performed by thai scientists from many institutions and by workers at the u.s. army's seato medical research laboratory in bangkok, thailand. careful clinical and physiological studies provided the initial description of dss. dss cases were caused by each of the four dengue viruses (denv) and not chikungunya (chik) virus o ...	26085471
dengue: profile of hematological and biochemical dynamics.	the objective of this study was to correlate laboratory tests during the evolution of dengue fever, comparing frequencies between the different clinical forms in order to use test results to predict the severity of the disease.	23049382
chikungunya and dengue fever among hospitalized febrile patients in northern tanzania.	consecutive febrile admissions were enrolled at two hospitals in moshi, tanzania. confirmed acute chikungunya virus (chikv), dengue virus (denv), and flavivirus infection were defined as a positive polymerase chain reaction (pcr) result. presumptive acute denv infection was defined as a positive anti-denv immunoglobulin m (igm) enzyme-linked immunsorbent assay (elisa) result, and prior flavivirus exposure was defined as a positive anti-denv igg elisa result. among 870 participants, pcr testing w ...	22232469
dengue fever treatment with carica papaya leaves extracts.	the main objective of the current study is to investigate the potential of carica papaya leaves extracts against dengue fever in 45 year old patient bitten by carrier mosquitoes. for the treatment of dengue fever the extract was prepared in water. 25 ml of aqueous extract of c. papaya leaves was administered to patient infected with dengue fever twice daily i.e. morning and evening for five consecutive days. before the extract administration the blood samples from patient were analyzed. platelet ...	23569787
emergence of dengue in andaman & nicobar archipelago: eco-epidemiological perspective.		21911978
development of assure dengue iga rapid test for the detection of anti-dengue iga from dengue infected patients.	rapid and early dengue diagnosis is essential for patient management and early disease intervention. mp diagnostics assure(®) dengue iga rapid test (dengue iga rt) was developed for the rapid detection of anti-dengue iga in patients' biological samples. the performance of dengue iga rt was examined using multiple categories of well-characterized samples.	21887054
vertical transmission of key west dengue-1 virus by aedes aegypti and aedes albopictus (diptera: culicidae) mosquitoes from florida.	following the 2009 and 2010 dengue-1 (denv-1) outbreaks in key west, fl, we used florida aedes aegypti (l.) mosquitoes and denv-1 isolated from key west in 2010 to test the hypothesis that if the 2009 and 2010 denv-1 genome sequences are similar, then vertical transmission of denv-1 from infected ae. aegypti female mosquitoes to their eggs could have served as an interepidemic reservoir between outbreaks. we also investigated the ability of florida aedes albopictus (skuse) mosquitoes to vertical ...	24843934
atypical dengue meningitis in makkah, saudi arabia with slow resolving, prominent migraine like headache, phobia, and arrhythmia.	although dengue meningitis is a rare presentation of dengue infection, our aim is to focus on atypical presentation of dengue meningitis that may appear in dengue endemic area like the makkah region. we report two cases of clinical meningitis with positive dengue virus (denv) igm in cerebrospinal fluid, followed for minimal 3 months for their prominent attacks of migraine like headache, phobia, and arrhythmia. with special consideration to attack time, type, severity, and respond to classical th ...	24672183
transition in the cause of fever from malaria to dengue, northwestern ecuador, 1990-2011.	in tropical areas, the predominant cause of fever has historically been malaria. however by 2011, among febrile patients in northwestern ecuador, dengue was identified in 42% and malaria in none. this finding suggests a transition in the cause of fever from malaria to other illnesses, such as dengue.	24047566
global consensus sequence development and analysis of dengue ns3 conserved domains.	the dengue virus (denv) genome encodes 10 different genes including the ns3 gene, which has a protease and helicase domain used in virus replication. this domain is a potential target for antiviral agents against dengue. due to a high mutation rate, denv is classified into four major serotypes (denv1-denv4). this study was designed to perform conservancy analysis of all four serotypes by drawing a consensus sequence for each serotype and then drawing a global consensus sequence to study conserve ...	24083095
dual role of commensal bacteria in viral infections.	with our abilities to culture and sequence the commensal bacteria that dwell on and within a host, we can now study the host in its entirety, as a supraorganism that must be navigated by the pathogen invader. at present, the majority of studies have focused on the interaction between the host's microbiota and bacterial pathogens. this is not unwarranted, given that bacterial pathogens must compete with commensal organisms for the limited territory afforded by the host. however, viral pathogens a ...	23947358
cell phone-based system (chaak) for surveillance of immatures of dengue virus mosquito vectors.	capture of surveillance data on mobile devices and rapid transfer of such data from these devices into an electronic database or data management and decision support systems promote timely data analyses and public health response during disease outbreaks. mobile data capture is used increasingly for malaria surveillance and holds great promise for surveillance of other neglected tropical diseases. we focused on mosquito-borne dengue, with the primary aims of: 1) developing and field-testing a ce ...	23926788
commentary.		24250192
dengue: a growing menace -- a snapshot of recent facts, figures & remedies.	dengue is specially owing to inadequate water supply and poor solid waste management , which are favorable for multiplication of the main vectors including the aedes ageypti coupled with lack of proven anti viral therapy and no proven efficient vaccine .there are many cases of both dengue shock syndrome and dengue haemmorhagic fever making it a major public health burden sending ominous signal resulting both rising morbidity & mortality, deleterious effect on daly [disability adjusted life year] ...	23847455
dengue vaccine: a valuable asset for the future.	dengue has emerged as one of the major global public health problems. the disease has broken out of its shell and has spread due to increased international travel and climatic changes. globally, over 2.5 billion people accounting for >40% of the world's population are at risk from dengue. since the 1940s, dengue vaccines have been under investigation. a live-attenuated tetravalent vaccine based on chimeric yellow fever-dengue virus (cyd-tdv) has progressed to phase iii efficacy studies. dengue v ...	25424928
papaya extract to treat dengue: a novel therapeutic option?	dengue is a viral disease that today affects a vast number of people in over 125 countries and is responsible for a sizable number of deaths. in the absence of an effective antiviral drug to treat the disease, various treatments are being investigated. studies have indicated that the juice of the leaves of the carica papaya plant from the family caricaceae could help to increase the platelet levels in these patients. this review describes some of the published studies on this topic. the search w ...	24971201
mucocutaneous manifestations of dengue fever.	dengue viral infection is a cause of considerable morbidity and mortality and may be associated with a variety of mucocutaneous manifestations that may provide important early clues to the diagnosis of this condition. cutaneous and mucosal findings like confluent erythema, morbilliform eruptions, and hemorrhagic lesions may figure prominently in the clinical features of dengue. the differential diagnoses include a large number of bacterial and viral exanthems as well as drug rash.	20418984
dengue fever-induced cold-agglutinin syndrome.		25469236
acute pancreatitis complicating severe dengue.	dengue is an arthropod borne viral infection endemic in tropical and subtropical continent. severe dengue is life threatening. various atypical presentations of dengue have been documented. but we present a rare and fatal complication of severe dengue in form of acute pancreatitis. a 27-year-old male had presented with severe dengue in decompensated shock and with pain in abdomen due to pancreatitis. the pathogenesis of acute pancreatitis in dengue is not clearly understood, but various mechanis ...	24926168
viruses and the microbiota.	every surface of the human body is colonized by a diverse microbial community called the microbiota, yet the impact of microbiota on viruses is unclear. recent research has advanced our understanding of how microbiota influence viral infection. microbiota inhibit infection of some viruses and promote infection of other viruses. these effects can occur through direct and/or indirect effects on the host and/or virus. this review examines the known effects and mechanisms by which the microbiota inf ...	25821837
functional genomics approach for the identification of human host factors supporting dengue viral propagation.	dengue virus (denv) is endemic throughout tropical regions of the world and there are no approved treatments or anti-transmission agents currently available. consequently, there exists an enormous unmet need to treat the human diseases caused by denv and block viral transmission by the mosquito vector. rnai screening represents an efficient method to expand the pool of known host factors that could become viable targets for treatments or provide rationale to consider available drugs as anti-denv ...	24696344
latest developments and future directions in dengue vaccines.	dengue is a mosquito-borne disease which is currently an expanding global health problem. the disease is caused by four closely related viruses, the dengue virus. there are no specific dengue therapeutics and prevention is currently limited to vector control measures. development of an effective tetravalent dengue vaccine would therefore represent a major advance in the control of the disease and is considered a high public health priority. while a licensed dengue vaccine is not yet available, t ...	24757522
seropositive status of dengue virus infection among blood donors in north malaysia.		24678182
urban epidemic of dengue virus serotype 3 infection, senegal, 2009.	an urban epidemic of dengue in senegal during 2009 affected 196 persons and included 5 cases of dengue hemorrhagic fever and 1 fatal case of dengue shock syndrome. dengue virus serotype 3 was identified from all patients, and aedes aegypti mosquitoes were identified as the primary vector of the virus.	24572297
dengue in costa rica: the gap in local scientific research.		17316494
fever screening at airports and imported dengue.	airport fever screening in taiwan, july 2003-june 2004, identified 40 confirmed dengue cases. results obtained by capture immunoglobulin (ig) m and igg enzyme-linked immunoassay, real time 1-step polymerase chain reaction, and virus isolation showed that 33 (82.5%) of 40 patients were viremic. airport fever screening can thus quickly identify imported dengue cases.	15757566
reemergence of dengue in southern texas, 2013.	during a dengue epidemic in northern mexico, enhanced surveillance identified 53 laboratory-positive cases in southern texas; 26 (49%) patients acquired the infection locally, and 29 (55%) were hospitalized. of 83 patient specimens that were initially igm negative according to elisa performed at a commercial laboratory, 14 (17%) were dengue virus positive by real-time reverse transcription pcr performed at the centers for disease control and prevention. dengue virus types 1 and 3 were identified ...	27191223
the brazilian zika virus strain causes birth defects in experimental models.	zika virus (zikv) is an arbovirus belonging to the genus flavivirus (family flaviviridae) and was first described in 1947 in uganda following blood analyses of sentinel rhesus monkeys. until the twentieth century, the african and asian lineages of the virus did not cause meaningful infections in humans. however, in 2007, vectored by aedes aegypti mosquitoes, zikv caused the first noteworthy epidemic on the yap island in micronesia. patients experienced fever, skin rash, arthralgia and conjunctiv ...	27279226
spontaneous arterial hemorrhage as a complication of dengue.	bleeding complications of dengue hemorrhagic fever such as epistaxis, gum bleeding, gastrointestinal bleeding, hypermenorrhea, hematuria, and thrombocytopenia have been documented. a 49-year-old female presented with complaints of intermittent high-grade fever for the past 4 days, lower abdominal pain and altered sensorium for 1 day. laboratory investigations revealed severe anemia, mild thrombocytopenia, hypofibrinogenemia, and positive dengue serology. emergency ultrasound examination of the a ...	27275081
primary dengue virus infections induce differential cytokine production in mexican patients.	severe dengue pathogenesis is not fully understood, but high levels of proinflammatory cytokines have been associated with dengue disease severity. in this study, the cytokine levels in 171 sera from mexican patients with primary dengue fever (df) and dengue haemorrhagic fever (dhf) from dengue virus (denv) 1 (n = 116) or 2 (n = 55) were compared. df and dhf were defined according to the patient's clinical condition, the primary infections as indicated by igg enzymatic immunoassay negative resul ...	27008374
can radiology play a role in early diagnosis of dengue fever?	dengue fever (df) is a viral hemorrhagic fever causing severe morbidity and mortality in affected patients.	27042608
correlation study between platelet count, leukocyte count, nonhemorrhagic complications, and duration of hospital stay in dengue fever with thrombocytopenia.	dengue is one of the common diseases presenting as fever with thrombocytopenia, also causing significant morbidity and complications.	27453855
dengue virus: a global human threat: review of literature.	dengue is an acute viral illness caused by rna virus of the family flaviviridae and spread by aedes mosquitoes. presenting features may range from asymptomatic fever to dreaded complications such as hemorrhagic fever and shock. a cute-onset high fever, muscle and joint pain, myalgia, cutaneous rash, hemorrhagic episodes, and circulatory shock are the commonly seen symptoms. oral manifestations are rare in dengue infection; however, some cases may have oral features as the only presenting manifes ...	27011925
chikungunya virus susceptibility & variation in populations of aedes aegypti (diptera: culicidae) mosquito from india.	although having immense clinical relevance, yet only a few studies have been targeted to understand the chikungunya virus (chikv) susceptibility and growth in aedes aegypti populations from india. this study was undertaken to investigate chikv susceptibility and growth kinetics in ae. aegypti along with genetic heterogeneity of ae. aegypti populations.	26905240
knowledge, attitude, and practices regarding vector-borne diseases in western jamaica.	outbreaks of vector-borne diseases (vbds) such as dengue and malaria can overwhelm health systems in resource-poor countries. environmental management strategies that reduce or eliminate vector breeding sites combined with improved personal prevention strategies can help to significantly reduce transmission of these infections.	27036722
waiting for chikungunya fever in argentina: spatio-temporal risk maps.	chikungunya virus (chikv) transmission has been detected in america in 2013 and recently reached south up to bolivia, brazil and paraguay, bordering countries of argentina. the presence of the mosquito aedes aegypti in half of the country together with the regional context drove us to make a rapid assessment of transmission risk. temperature thresholds for vector breeding and for virus transmission, together with adult activity from the literature, were mapped on a monthly basis to estimate risk ...	25946252
high dose intraveneous vitamin c and chikungunya fever: a case report.	the chikungunya (chikv) fever is a viral disease produced by a single-stranded rna alphavirus from the togaviridae genus. its transmission occurs only through mosquito vectors, principally aedes aegypti. it requires a human-mosquito-human transmission cycle. it is associated with severe arthritis/arthralgias, myalgias, high fever, headache, and maculopapular rash. joint ache appears to be symmetrical. the virus has an incubation period of 2 to 7 days, where the high fever is typically presented. ...	25705076
chikungunya virus outbreak, dominica, 2014.		25898214
east/central/south african genotype chikungunya virus, brazil, 2014.		25898939
chikungunya fever outbreak, bhutan, 2012.	in 2012, chikungunya virus (chikv) was reported for the first time in bhutan. igm elisa results were positive for 36/210 patient samples; pcr was positive for 32/81. phylogenetic analyses confirmed that bhutan chikv belongs to the east/central/south african genotype. appropriate responses to future outbreaks require a system of surveillance and improved laboratory capacity.	24047543
genomes to hits in silico - a country path today, a highway tomorrow: a case study of chikungunya.	these are exciting times for bioinformaticians, computational biologists and drug designers with the genome and proteome sequences and related structural databases growing at an accelerated pace. the post-genomic era has triggered high expectations for a rapid and successful treatment of diseases. however, in this biological information rich and functional knowledge poor scenario, the challenges are indeed grand, no less than the assembly of the genome of the whole organism. these include functi ...	23260020
chikungunya virus infection, brazzaville, republic of congo, 2011.		23968609
outbreak of chikungunya virus infection, vanimo, papua new guinea.	in june 2012, health authorities in papua new guinea detected an increase in febrile illnesses in vanimo. chikungunya virus of the eastern/central/southern african genotype harboring the e1:a226v mutation was identified. this ongoing outbreak has spread to ≥8 other provinces and has had a harmful effect on public health.	23965757
nonstructural protein 2 (nsp2) of chikungunya virus (chikv) enhances protective immunity mediated by a chikv envelope protein expressing dna vaccine.	chikungunya virus (chikv) is an important emerging mosquito-borne alphavirus, indigenous to tropical africa and asia. it can cause epidemic fever and acute illness characterized by fever and arthralgias. the epidemic cycle of this infection is similar to dengue and urban yellow fever viral infections. the generation of an efficient vaccine against chikv is necessary to prevent and/or control the disease manifestations of the infection. in this report, we studied immune response against a chikv-e ...	23409931
estimation of population size and dispersal of aedes polynesiensis on toamaro motu, french polynesia.	mark-release-recapture methods were used to compare aedes polynesiensis marks adult numbers and dispersal between dry and wet seasons in a closed population on a small island (motu) in french polynesia. females were more than three times more common during wet (december 2008) than dry (may 2007) season samplings although high numbers of vectors were collected during both seasons. lincoln-petersen estimates for ae. polynesiensis females on the motu were 6,055 per hectare for the dry season and 18 ...	23025176
two disciplines, one priority: the seamless integration of human and veterinary microbiology is urgent.		26038422
perinatal chikungunya in twins.	we report a case of vertically transmitted chikungunya infection in heterozygous twin neonates presenting as seizures, encephalopathy, midfacial hyperpigmentation, anemia, and thrombocytopenia. this could be considered as a rare cause of neonatal seizure and identification would help in appropriate management.	27857791
chikungunya fever among patients with acute febrile illness attending a tertiary care hospital in mumbai.	chikungunya fever (chik) is an arboviral disease. dengue fever (deng) and chik are indistinguishable clinically and need to be differentiated by laboratory investigations.	27365916
a comparative study of clinical features between monotypic and dual infection cases with chikungunya virus and dengue virus in west bengal, india.	chikungunya virus (chikv) and dengue virus (denv) are circulating individually in the state of west bengal, india. however, after 1965 the dual-infection caused by both viruses had not been recorded until 2010. in 2010, an investigation of the febrile cases was carried out to confirm the involvement of both viruses simultaneously. a total of 550 blood samples were tested for the detection of immunoglobulin m (igm) antibody against both chikv and denv. serology by the enzyme-linked immunosorbent ...	22492160
molecular characterization of chikungunya virus, philippines, 2011-2013.	during 2011-2013, a nationwide outbreak of chikungunya virus infection occurred in the philippines. the asian genotype was identified as the predominant genotype; sporadic cases of the east/central/south african genotype were detected in mindanao. further monitoring is needed to define the transmission pattern of this virus in the philippines.	27088593
the chikungunya virus: an emerging us pathogen.	the chikungunya (chik) virus was recently reported by the cdc to have spread to the united states. we report an early documented case of chik from the state of pennsylvania after a patient recently returned from haiti in june of 2014.	27006742
cutaneous manifestations in patients suspected of chikungunya disease.	an epidemic of chikungunya disease occurred in india during late 2005 through 2006 affecting nearly 1,400,000 people.	20101307
movement of chikungunya virus into the western hemisphere.		25061832
preparedness for threat of chikungunya in the pacific.	chikungunya virus (chikv) caused significant outbreaks of illness during 2005-2007 in the indian ocean region. chikungunya outbreaks have also occurred in the pacific region, including in papua new guinea in 2012; new caledonia in april 2013; and yap state, federated states of micronesia, in august 2013. chikv is a threat in the pacific, and the risk for further spread is high, given several similarities between the pacific and indian ocean chikungunya outbreaks. island health care systems have ...	25062306
chikungunya virus in the americas--what a vectorborne pathogen can do.		25184860
mucocutaneous manifestations of chikungunya fever: a study from an epidemic in coastal karnataka.	chikungunya fever (cf) epidemic has recently re-emerged in india affecting large population. mucocutaneous manifestations are an important clinical feature of the disease. we have reviewed mucocutaneous manifestations of the disease during a recent epidemic in coastal karnataka.	21772590
bed bugs: clinical relevance and control options.	since the late 1990s, bed bugs of the species cimex lectularius and cimex hemipterus have undergone a worldwide resurgence. these bed bugs are blood-sucking insects that readily bite humans. cutaneous reactions may occur and can start out as small macular lesions that can develop into distinctive wheals of around 5 cm in diameter, which are accompanied by intense itching. occasionally, bullous eruptions may result. if bed bugs are numerous, the patient can present with widespread urticaria or ey ...	22232375
epidemiological investigation of an outbreak of chikungunya in hyderabad and nalgonda districts of andhra pradesh, india.	after about three decades, chikungunya infection has re-emerged in india and the first cases were reported in december, 2005. the outbreak has currently affected about 8 states in the country. although known to be commonly non fatal, since the present outbreak involved a large population, it has been raised as an issue of public health concern and also attracted wide media attention. the clinico-epidemiological and entomological review of the chikungunya outbreak situation in hyderabad and nalgo ...	21475442
distinguishing between zika and spondweni viruses.		27843157
detection of autochthonous zika virus transmission in sincelejo, colombia.		27089253
bloodfeeding patterns of sylvatic arbovirus vectors in southeastern senegal.	dengue (denv), yellow fever (yfv) and chikungunya (chikv) viruses circulate in sylvatic, enzootic transmission cycles in southeastern senegal, but understanding of the vector-host interactions involved is limited.	23423342
highly diversified zika viruses imported to china, 2016.		27209301
emerging infectious disease and fast-track publication: when public health gets priority over the formality of scholarly publishing.		27223865
projecting month of birth for at-risk infants after zika virus disease outbreaks.	the marked increase in infants born with microcephaly in brazil after a 2015 outbreak of zika virus (zika virus) disease suggests an association between maternal zika virus infection and congenital microcephaly. to project the timing of delivery of infants born to mothers infected during early pregnancy in 1 city in bahia state, brazil, we incorporated data on reported zika virus disease cases and microcephaly cases into a graphical schematic of weekly birth cohorts. we projected that these birt ...	27088494
threat from emerging vectorborne viruses.		27551712
asian genotype zika virus detected in traveler returning to mexico from colombia, october 2015.		27088574
tropical islands as new hubs for emerging arboviruses.		27088243
bioethical considerations at times of zika virus.		27462882
brazil's scientists scramble to solve the zika puzzle.	the world health organization has declared the recent leap in the number of microcephaly cases and their suspected association with zika virus a public health emergency of international concern. ana bispo tells andréia azevedo soares why brazil should have some scientific answers in coming months.	26966326
autochthonous chikungunya fever in traveler returning to japan from cuba.		27533717
the epidemiology and transmissibility of zika virus in girardot and san andres island, colombia, september 2015 to january 2016.	transmission of zika virus (zikv) was first detected in colombia in september 2015. as of april 2016, colombia had reported over 65,000 cases of zika virus disease (zvd). we analysed daily surveillance data of zvd cases reported to the health authorities of san andres and girardot, colombia, between september 2015 and january 2016. zvd was laboratory-confirmed by reverse transcription-polymerase chain reaction (rt-pcr) in the serum of acute cases within five days of symptom onset. we use daily i ...	27452806
zika - global concern.		27610070
public health round-up.		27516631
larvicidal efficacies of plants from midwestern brazil: melianodiol from guarea kunthiana as a potential biopesticide against aedes aegypti.	a total of 36 ethanol extracts from different anatomical parts of 27 plant species (18 families), native to the pantanal and cerrado biomes in midwest brazil, was assessed for their effect against aedes aegypti larvae, the vector of dengue, hemorrhagic dengue, zika and chikungunya fevers. only the extract obtained from seeds of guarea kunthiana (meliaceae) proved active (lc50 = 169.93 μg/ml). a bioassay-guided investigation of this extract led to the isolation and identification of melianodiol, ...	27333366
zika is not a reason for missing the olympic games in rio de janeiro: response to the open letter of dr attaran and colleagues to dr margaret chan, director - general, who, on the zika threat to the olympic and paralympic games.	attaran and colleagues in an open letter to who expressed their concern about the upcoming olympic and paralympic games in rio de janeiro and the threat posed by the zika epidemic (attaran 2016). we agree that zika virus is of great public health concern and much remains to be known about this disease. care should be taken to reduce the risk of infection, especially to pregnant women. however, we argue that this is not sufficient reason for changing the original plans for the games, in particula ...	27304097
microcephaly in north-east brazil: a retrospective study on neonates born between 2012 and 2015.	to assess the number of children born with microcephaly in the state of paraíba, north-east brazil.	27821886
editorial brain malformation surveillance in the zika era.	the current surveillance systems for congenital microcephaly are necessary to monitor the impact of zika virus (zikv) on the developing human brain, as well as the zikv prevention efforts. however, these congenital microcephaly surveillance systems are insufficient. abnormalities of neuronal differentiation, development and migration may occur among infants with normal head circumference who have intrauterine exposure to zikv. therefore, surveillance for congenital microcephaly does not ascertai ...	27891785