Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| first evidence of vertical infection of dengue virus 2 in aedes aegypti mosquitoes from sinaloa, mexico. | fourteen pools of aedes aegypti larvae collected within the urban area of culiacán, sinaloa, were analyzed by rt-pcr. the results demonstrate, for the first time, the vertical infection of serotype-2 dengue virus (denv-2) in sinaloa, mexico, suggesting that ae. aegypti acts as a natural reservoir of denv-2 in this region. | 2018 | 29485942 |
| hypericum japonicum: a double-headed sword to combat vector control and cancer. | mosquito control with naturally derived herbal insecticides has gained much momentum, with the increased insecticide resistance of vectors and the multiple infectious diseases spread by them. yet, recent studies also suggest that mosquitoes could probably transmit some cancerous cells or cancer-causing viruses from one individual to another between their blood meals. the current research thus focused on the screening and characterization of novel plants with both mosquitocidal and anticancerous ... | 2018 | 29476319 |
| in tune with nature: wolbachia does not prevent pre-copula acoustic communication in aedes aegypti. | mosquito-borne diseases are rapidly spreading to vast territories, putting at risk most of the world's population. a key player in this scenario is aedes aegypti, a hematophagous species which hosts and transmits viruses causing dengue and other serious illnesses. since vector control strategies relying only on insecticides have proven unsustainable, an alternative method involving the release of wolbachia-harboring individuals has emerged. its successful implementation vastly depends on how fit ... | 2018 | 29471864 |
| dengue viruses and promising envelope protein domain iii-based vaccines. | dengue viruses are emerging mosquito-borne pathogens belonging to flaviviridae family which are transmitted to humans via the bites of infected mosquitoes aedes aegypti and aedes albopictus. because of the wide distribution of these mosquito vectors, more than 2.5 billion people are approximately at risk of dengue infection. dengue viruses cause dengue fever and severe life-threatening illnesses as well as dengue hemorrhagic fever and dengue shock syndrome. all four serotypes of dengue virus can ... | 2018 | 29470620 |
| using adult aedes aegypti females to predict areas at risk for dengue transmission: a spatial case-control study. | traditional indices for measuring dengue fever risk in a given area are based on the immature forms of the vector (larvae and pupae surveys). however, this is inefficient because only adult female mosquitoes actually transmit the virus. based on these assumptions, our objective was to evaluate the association between an entomological index obtained from adult mosquito traps and the occurrence of dengue in a hyperendemic area. additionally, we compared its cost to that of the breteau index (bi). | 2018 | 29462598 |
| seasonal distribution and container preference ratio of the dengue fever vector (aedes aegypti, diptera: culicidae) in rawalpindi, pakistan. | aedes aegypti (l.) and aedes albopictus (skuse) are known vectors of dengue, chikungunya, and other pathogens; however, their ecology and role in virus transmission has not been well studied in pakistan. here, we report on an intensive survey of potential breeding sites of ae. aegypti in rawalpindi, punjab province, pakistan. the study continued for 11 mo and was divided into three seasons: january to june (pre-monsoon), july to september (monsoon), and october-november (post-monsoon). larval mo ... | 2018 | 29462424 |
| improving vector-borne pathogen surveillance: a laboratory-based study exploring the potential to detect dengue virus and malaria parasites in mosquito saliva. | vector-borne pathogen surveillance programmes typically rely on the collection of large numbers of potential vectors followed by screening protocols focused on detecting pathogens in the arthropods. these processes are laborious, time consuming, expensive, and require screening of large numbers of samples. to streamline the surveillance process, increase sample throughput, and improve cost-effectiveness, a method to detect dengue virus and malaria parasites (plasmodium falciparum) by leveraging ... | 2018 | 29460859 |
| entomological and epidemiological aspects of dengue epidemics in fortaleza, ceará, brazil, 2001-2012. | to characterize the entomological and epidemiological aspects of dengue epidemics occurred in fortaleza, ceará, brazil, from 2001 to 2012. | 2018 | 29451615 |
| dynamic remodeling of lipids coincides with dengue virus replication in the midgut of aedes aegypti mosquitoes. | we describe the first comprehensive analysis of the midgut metabolome of aedes aegypti, the primary mosquito vector for arboviruses such as dengue, zika, chikungunya and yellow fever viruses. transmission of these viruses depends on their ability to infect, replicate and disseminate from several tissues in the mosquito vector. the metabolic environments within these tissues play crucial roles in these processes. since these viruses are enveloped, viral replication, assembly and release occur on ... | 2018 | 29447265 |
| mosquitoes of northwestern uganda. | despite evidence of arbovirus activity in northwestern uganda (west nile sub-region), there is very limited information on the mosquito fauna of this region. the only published study reported 52 mosquito species in northwestern uganda but this study took place in 1950 and the information has not been updated for more than 60 yr. in january and june 2011, co2 baited-light traps were used to collect 49,231 mosquitoes from four different locations, paraa (9,487), chobe (20,025), sunguru (759), and ... | 2018 | 29444287 |
| the impact of insecticide applications on the dynamics of resistance: the case of four aedes aegypti populations from different brazilian regions. | in the tropics, the utilization of insecticides is still an important strategy for controlling aedes aegypti, the principle vector of dengue, chikungunya and zika viruses. however, increasing insecticide resistance in ae. aegypti populations might hinder insecticide efficacy on a long-term basis. it will be important to understand the dynamics and evolution of insecticide resistance by assessing its frequency and the mechanisms by which it occurs. | 2018 | 29432488 |
| optimal control approach for establishing wmelpop wolbachia infection among wild aedes aegypti populations. | wolbachia-based biocontrol has recently emerged as a potential method for prevention and control of dengue and other vector-borne diseases. major vector species, such as aedes aegypti females, when deliberately infected with wolbachia become less capable of getting viral infections and transmitting the virus to human hosts. in this paper, we propose an explicit sex-structured population model that describes an interaction of uninfected (wild) male and female mosquitoes and those deliberately inf ... | 2018 | 29429122 |
| a natural agonist of mosquito trpa1 from the medicinal plant cinnamosma fragrans that is toxic, antifeedant, and repellent to the yellow fever mosquito aedes aegypti. | plants produce various secondary metabolites that offer a potential source of novel insecticides and repellents for the control of mosquito vectors. plants of the genus cinnamosma are endemic to, and widely-distributed throughout, the island of madagascar. the barks of these species are commonly used in traditional medicines for treating a wide range of maladies. the therapeutic nature of the bark is thought to be associated with its enrichment of pungent drimane sesquiterpenes, which elicit ant ... | 2018 | 29425195 |
| evidence for chikungunya and dengue transmission in quelimane, mozambique: results from an investigation of a potential outbreak of chikungunya virus. | in january 2016, health authorities from zambézia province, mozambique reported the detection of some patients presenting with fever, arthralgia, and a positive result for chikungunya in an igm-based rapid diagnostic test (rdt). we initiated a study to investigate a potential chikungunya outbreak in the city of quelimane. | 2018 | 29415070 |
| aedes aegypti antiviral adaptive response against denv-2. | priming is the conceptual term defining memory phenomenon in innate immune response. numerous examples of enhanced secondary immune response have been described in diverse taxa of invertebrates; which naturally lacks memory response. in mosquitoes, a previous non-lethal challenge with some specific pathogens modify their immune response against the same microorganism; developing an improved antimicrobial reaction. in this work, we explore the ability of aedes aegypti to mount a higher antiviral ... | 2018 | 29408269 |
| existing and potential infection risk zones of yellow fever worldwide: a modelling analysis. | yellow fever cases are under-reported and the exact distribution of the disease is unknown. an effective vaccine is available but more information is needed about which populations within risk zones should be targeted to implement interventions. substantial outbreaks of yellow fever in angola, democratic republic of the congo, and brazil, coupled with the global expansion of the range of its main urban vector, aedes aegypti, suggest that yellow fever has the propensity to spread further internat ... | 2018 | 29398634 |
| immune response-related genes associated to blocking midgut dengue virus infection in aedes aegypti strains that differ in susceptibility. | aedes (stegomyia) aegypti, the principal global vector of dengue viruses, has differences in its' susceptibility to dengue virus infection. we compared the global expression of genes in the midguts of colombian ae. aegypti dengue-susceptible (cali-s) and dengue-refractory (cali-mib) field derived strains after ingesting either a sugarmeal, a bloodmeal, or a bloodmeal containing dengue virus serotype 2 (denv-2). microarray-based transcriptome analysis among treatments indicated a total of 4725 tr ... | 2018 | 29389079 |
| aedes mosquitoes and aedes-borne arboviruses in africa: current and future threats. | the zika crisis drew attention to the long-overlooked problem of arboviruses transmitted byaedesmosquitoes in africa. yellow fever, dengue, chikungunya and zika are poorly controlled in africa and often go unrecognized. however, to combat these diseases, both in africa and worldwide, it is crucial that this situation changes. here, we review available data on the distribution of each disease in africa, theiraedesvectors, transmission potential, and challenges and opportunities foraedescontrol. d ... | 2018 | 29382107 |
| an overview of mosquito vectors of zika virus. | the mosquito-borne arbovirus zika virus (zikv, flavivirus, flaviviridae), has caused an outbreak impressive by its magnitude and rapid spread. first detected in uganda in africa in 1947, from where it spread to asia in the 1960s, it emerged in 2007 on the yap island in micronesia and hit most islands in the pacific region in 2013. subsequently, zikv was detected in the caribbean, and central and south america in 2015, and reached north america in 2016. although zikv infections are in general asy ... | 2018 | 29481868 |
| vector competence of selected north americananophelesandculexmosquitoes for zika virus. | zika virus (zikv) is a vector-borne flavivirus that has caused recent outbreaks associated with serious disease in infants and newborns in the americas.aedesmosquitoes are the primary vectors for zikv, but little is known about the diversity of mosquitoes that can transmit zikv in north america. we chose three abundant north american mosquito species (anopheles freeborni,anopheles quadrimaculatus, andculex tarsalis) and one known vector species (aedes aegypti), fed them blood meals supplemented ... | 2018 | 29472998 |
| potential occurrence of zika from subtropical to temperate argentina considering the basic reproduction number (r0). | to assess the potential occurrence of zika transmission throughout argentina by the mosquito aedes aegypti considering the basic reproduction number (r0). | 2018 | 29466517 |
| alterations of mitochondrial electron transport chain and oxidative stress induced by alkaloid-like α-aminonitriles on aedes aegypti larvae. | aedes aegypti mosquitoes are responsible for dengue, chikungunya, and zika virus transmission in tropical and subtropical areas around the world. due to the absence of vaccines or antiviral drugs for human treatment, the majority of control strategies are targeted at ae. aegypti elimination. our research on mosquito control insecticidal agents has previously shown that the alkaloid girgensohnine and its analogues (α-aminonitriles) present in vitro acetylcholinesterase inhibition and in vivo inse ... | 2018 | 29463410 |
| synergistic effect of entomopathogenic fungus fusarium oxysporum extract in combination with temephos against three major mosquito vectors. | mosquito control using chemical insecticides is facing a major challenge due to development of insecticide resistance. improving the efficiency of existing insecticides using synergistic secondary metabolites of biological origin is increasingly being researched. herein, we evaluated the toxicity of fusarium oxysporum extract alone and in binary combinations with temephos, on larvae and pupae of anopheles stephensi, aedes aegypti and culex quinquefaciatus. f. oxysporum extract was characterized ... | 2018 | 29457957 |
| modeling the spread of the zika virus using topological data analysis. | zika virus (zikv), a disease spread primarily through the aedes aegypti mosquito, was identified in brazil in 2015 and was declared a global health emergency by the world health organization (who). epidemiologists often use common state-level attributes such as population density and temperature to determine the spread of disease. by applying techniques from topological data analysis, we believe that epidemiologists will be able to better predict how zikv will spread. we use the vietoris-rips fi ... | 2018 | 29438377 |
| integrated vector control of aedes aegypti mosquitoes around target houses. | the developing fetuses of pregnant women are at high risk of developing serious birth defects following zika virus infections. we applied an integrated vector control (ivc) approach using source reduction, larviciding, and mass trapping with non-insecticidal sticky traps to protect targeted houses by reducing the density of female aedes aegypti mosquitoes. | 2018 | 29422087 |
| zika and aedes aegypti: new and old challenges. | infection with the zika virus had a great impact not only on pregnant women and newborns, but also on public health, on popular ideas about aedes aegypti and with respect to women's social rights. the objective of this paper is to identify this impact and the historical, social and health changes of the disease and the legacy of the zika virus. interventions by researchers from different specialties foster conditions for more comprehensive investigations into future epidemic threats in brazil an ... | 2018 | 29412263 |
| zika virus mb16-23 in mosquitoes, miami-dade county, florida, usa, 2016. | we isolated a strain of zika virus, mb16-23, from aedes aegypti mosquitoes collected in miami beach, florida, usa, on september 2, 2016. phylogenetic analysis suggests that mb16-23 most likely originated from the caribbean region. | 2018 | 29400646 |
| mission accomplished? we need a guide to the 'post release' world of wolbachia for aedes-borne disease control. | historically, sustained control of aedes aegypti, the vector of dengue, chikungunya, yellow fever, and zika viruses, has been largely ineffective. subsequently, two novel 'rear and release' control strategies utilizing mosquitoes infected with wolbachia are currently being developed and deployed widely. in the incompatible insect technique, male aedes mosquitoes, infected with wolbachia, suppress populations through unproductive mating. in the transinfection strategy, both male and female wolbac ... | 2018 | 29396201 |
| larvicidal activity of selected plant extracts and their combination against the mosquito vectors culex quinquefasciatus and aedes aegypti. | in order to develop an environment-friendly botanical mosquito larvicide alternative to the chemical larvicides, extracts were made from the leaves of hyptis suaveolens, lantana camara, nerium oleander, and tecoma stans with three organic solvents such as methanol (me), chloroform (ch), and petroleum ether (pe) using a soxhlet extractor. the plant extracts were screened for larvicidal activity individually and in combination against the larvae of aedes aegypti and culex quinquefasciatus as per w ... | 2018 | 29460245 |
| mosquito saliva: the hope for a universal arbovirus vaccine? | arthropod-borne viruses (arboviruses) are taxonomically diverse causes of significant morbidity and mortality. in recent decades, important mosquito-borne viruses such as west nile, chikungunya, dengue, and zika have re-emerged and spread widely, in some cases pandemically, to cause serious public health emergencies. there are no licensed vaccines against most of these viruses, and vaccine development and use has been complicated by the number of different viruses to protect against, by subtype ... | 2018 | 29617849 |
| the potential impacts of 21st century climatic and population changes on human exposure to the virus vector mosquitoaedes aegypti. | the mosquitoaedes (ae). aegyptitransmits the viruses that cause dengue and chikungunya, two globally-important vector-borne diseases. we investigate how choosing alternate emissions and/or socioeconomic pathways may modulate future human exposure toae. aegypti. occurrence patterns forae. aegyptifor 2061-2080 are mapped globally using empirically downscaled air temperature and precipitation projections from the community earth system model, for the representative concentration pathway (rcp) 4.5 a ... | 2018 | 29610543 |
| identification of hub genes and pathways in zika virus infection using rna-seq data: a network-based computational approach. | zika virus (zikv), a single-strand rna flavivirus, is transmitted primarily through aedes aegypti. the recent outbreaks in america and unexpected association between zikv infection and birth defects have triggered the global attention. this vouches to understand the molecular mechanisms of zikv infection to develop effective drug therapy. a systems-level understanding of biological process affected by zikv infection in fetal brain sample led us to identify the candidate genes for pharmaceutical ... | 2018 | 29608426 |
| pyrethroid resistance persists after ten years without usage against aedes aegypti in governmental campaigns: lessons from são paulo state, brazil. | aedes aegypti, vector of dengue, chikungunya and zika viruses, is found at high densities in tropical urban areas. the dissemination of this vector is partially the consequence of failures in current vector control methods, still mainly relying upon insecticides. in the state of são paulo (sp), brazil, public health managers employed pyrethroids against ae. aegypti adults from 1989 to 2000, when a robust insecticide resistance monitoring system detected resistance to pyrethroids in several ae. a ... | 2018 | 29601580 |
| zika virus pathogenesis in infant mice after natural transmission by the bite of infected mosquitoes. | the objective of this study was to understand natural disease progression in infant cd1 mice after the bite of aedes aegypti mosquitoes infected by the zika virus (zikv, mr-766 strain). | 2018 | 29597193 |
| commentary: zika virus in the americas-yet anotherarbovirusthreat. | 2018 | 29593683 | |
| diverse laboratory colonies of aedes aegypti harbor the same adult midgut bacterial microbiome. | host-associated microbes, collectively known as the microbiota, play an important role in the biology of multicellular organisms. in mosquito vectors of human pathogens, the gut bacterial microbiota influences vectorial capacity and has become the subject of intense study. in laboratory studies of vector biology, genetic effects are often inferred from differences between geographically and genetically diverse colonies of mosquitoes that are reared in the same insectary. it is unclear, however, ... | 2018 | 29587819 |
| a vaccinia-based single vector construct multi-pathogen vaccine protects against both zika and chikungunya viruses. | zika and chikungunya viruses have caused major epidemics and are transmitted by aedes aegypti and/or aedes albopictus mosquitoes. the "sementis copenhagen vector" (scv) system is a recently developed vaccinia-based, multiplication-defective, vaccine vector technology that allows manufacture in modified cho cells. herein we describe a single-vector construct scv vaccine that encodes the structural polyprotein cassettes of both zika and chikungunya viruses from different loci. a single vaccination ... | 2018 | 29581442 |
| characterization of the adult aedes aegypti early midgut peritrophic matrix proteome using lc-ms. | the aedes aegypti mosquito is the principal vector of arboviruses such as dengue, chikungunya, yellow fever, and zika virus. these arboviruses are transmitted during adult female mosquito bloodfeeding. while these viruses must transverse the midgut to replicate, the blood meal must also reach the midgut to be digested, absorbed, or excreted, as aggregation of blood meal metabolites can be toxic to the female mosquito midgut. the midgut peritrophic matrix (pm), a semipermeable extracellular layer ... | 2018 | 29570734 |
| treatment of chikungunya chronic arthritis: a systematic review. | chikungunya (chik) is a tropical arbovirus, transmitted by the female mosquito aedes aegypti and aedes albopictus. in brazil, there have been cases reported since 2014. the initial manifestations of this virus are sudden onset high fever, headache, chills, rashes, myalgia and intense joint pain. usually, chik presents the acute and chronic phases, the latter characterized by bilateral polyarthralgia, which can last for months or even years. during this period, autoimmune diseases can be triggere ... | 2018 | 29561944 |
| model-based inference from multiple dose, time course data reveals wolbachia effects on infection profiles of type 1 dengue virus in aedes aegypti. | infection is a complex and dynamic process involving a population of invading microbes, the host and its responses, aimed at controlling the situation. depending on the purpose and level of organization, infection at the organism level can be described by a process as simple as a coin toss, or as complex as a multi-factorial dynamic model; the former, for instance, may be adequate as a component of a population model, while the latter is necessary for a thorough description of the process beginn ... | 2018 | 29558464 |
| mosquito-borne human viral diseases: whyaedes aegypti? | although numerous viruses are transmitted by mosquitoes, four have caused the most human suffering over the centuries and continuing today. these are the viruses causing yellow fever, dengue, chikungunya, and zika fevers. africa is clearly the ancestral home of yellow fever, chikungunya, and zika viruses and likely the dengue virus. several species of mosquitoes, primarily in the genusaedes, have been transmitting these viruses and their direct ancestors among african primates for millennia allo ... | 2018 | 29557341 |
| dengue virus infection inaedes albopictusduring the 2014 autochthonous dengue outbreak in tokyo metropolis, japan. | in 2014 in japan, 162 autochthonous dengue cases were reported for the first time in nearly 70 years. here, we report the results of the detection and isolation of dengue virus (denv) from mosquitoes collected in tokyo metropolis in 2014 and 2015. the phylogenetic relationship among denv isolates from mosquitoes and from patients based on both the entire envelope gene and whole coding sequences was evaluated. herein, 2,298 female and 956 maleaedes albopictusmosquitoes were collected at six suspe ... | 2018 | 29557338 |
| identification of aanat5b as a spermine n-acetyltransferase in the mosquito, aedes aegypti. | mosquitoes transmit a number of diseases in animals and humans, including dengue, chikungunya and zika viruses that affect millions of people each year. controlling the disease-transmitting mosquitoes has proven to be a successful strategy to reduce the viruses transmission. polyamines are required for the life cycle of the rna viruses, chikungunya virus and zika virus, and a depletion of spermidine and spermine in the host via induction of spermine n-acetyltransferase restricts their replicatio ... | 2018 | 29554129 |
| the mixture of cashew nut shell liquid and castor oil results in an efficient larvicide against aedes aegypti that does not alter embryo-fetal development, reproductive performance or dna integrity. | dengue fever, chikungunya fever and zika virus are epidemics in brazil that are transmitted by mosquitoes, such as aedes aegypti or aedes albopictus. the liquid from shells of cashew nuts is attractive for its important biological and therapeutic activities, which include toxicity to mosquitoes of the genus aedes. the present study evaluated the effects of a mixture of surfactants from natural cashew nutshell liquid and castor oil (named talcc-20) on the mortality of larvae and on the reproducti ... | 2018 | 29554095 |
| mapping the virome in wild-caught aedes aegypti from cairns and bangkok. | medically important arboviruses such as dengue, zika, and chikungunya viruses are primarily transmitted by the globally distributed mosquito aedes aegypti. increasing evidence suggests that transmission can be influenced by mosquito viromes. herein rna-seq was used to characterize rna metaviromes of wild-caught ae. aegypti from bangkok (thailand) and from cairns (australia). the two mosquito populations showed a high degree of similarity in their viromes. blast searches of assembled contigs sugg ... | 2018 | 29549363 |
| estimating the probability of dengue virus introduction and secondary autochthonous cases in europe. | given the speed of air travel, diseases even with a short viremia such as dengue can be easily exported to dengue naïve areas within 24 hours. we set out to estimate the risk of dengue virus introductions via travelers into europe and number of secondary autochthonous cases as a result of the introduction. we applied mathematical modeling to estimate the number of dengue-viremic air passengers from 16 dengue-endemic countries to 27 european countries, taking into account the incidence of dengue ... | 2018 | 29545610 |
| house screening with insecticide-treated netting provides sustained reductions in domestic populations of aedes aegypti in merida, mexico. | there is a need for effective methods to control aedes aegypti and prevent the transmission of dengue, chikungunya, yellow fever and zika viruses. insecticide treated screening (its) is a promising approach, particularly as it targets adult mosquitoes to reduce human-mosquito contact. | 2018 | 29543805 |
| the seasonal influence of climate and environment on yellow fever transmission across africa. | yellow fever virus (yfv) is a vector-borne flavivirus endemic to africa and latin america. ninety per cent of the global burden occurs in africa where it is primarily transmitted by aedes spp, with aedes aegypti the main vector for urban yellow fever (yf). mosquito life cycle and viral replication in the mosquito are heavily dependent on climate, particularly temperature and rainfall. we aimed to assess whether seasonal variations in climatic factors are associated with the seasonality of yf rep ... | 2018 | 29543798 |
| risk perception and level of knowledge of diseases transmitted by aedes aegypti. | diseases caused by viruses such as dengue, chikungunya and zika are mosquito-borne diseases transmitted by aedes aegypti. we performed a cross-sectional study of healthcare personnel and the general population using questionnaires to identify the level of knowledge, attitudes and practices, and risk perception for dengue, chikungunya and zika. a total of 248 questionnaires were applied, 63.3% to healthcare personnel and 36.7% to the general population. of the healthcare personnel, 53% were men, ... | 2018 | 29538507 |
| dengue virus in aedes aegypti and aedes albopictus in urban areas in the state of rio grande do norte, brazil: importance of virological and entomological surveillance. | vector control remains the sole effective method to prevent dengue virus (denv) transmission, although a vaccine for dengue has recently become available and testing of its efficacy and coverage is being performed in multiple places. entomological surveillance is a key factor in alerting authorities to possible outbreaks, but until now natural denv infection of mosquito populations has been scarcely used as an early warning system to monitor fluctuating prevalence of infected mosquitoes. the pur ... | 2018 | 29534105 |
| chikungunya virus: a rheumatologist's perspective. | chikungunya virus (chikv) is an arthropod-borne alphavirus, transmitted by aedes aegypti and aedes albopictus mosquitoes. it is responsible for a febrile illness, typically accompanied by maculopapular rash and severe, incapacitating arthralgia. the disease, although generally self-limiting, frequently evolves into a long-lasting, debilitating rheumatic disorder, which shares many clinical features with rheumatoid arthritis (ra). the underlying mechanism by which chikv induces persistent arthrit ... | 2018 | 29533749 |
| comparative phylogeography ofaedesmosquitoes and the role of past climatic change for evolution within africa. | the study of demographic processes involved in species diversification and evolution ultimately provides explanations for the complex distribution of biodiversity on earth, indicates regions important for the maintenance and generation of biodiversity, and identifies biological units important for conservation or medical consequence. african and forest biota have both received relatively little attention with regard to understanding their diversification, although one possible mechanism is that ... | 2018 | 29531714 |
| natural variation in resistance to virus infection in dipteran insects. | the power and ease ofdrosophilagenetics and the medical relevance of mosquito-transmitted viruses have made dipterans important model organisms in antiviral immunology. studies of virus-host interactions at the molecular and population levels have illuminated determinants of resistance to virus infection. here, we review the sources and nature of variation in antiviral immunity and virus susceptibility in model dipteran insects, specifically the fruit flydrosophila melanogasterand vector mosquit ... | 2018 | 29522475 |
| update: noncongenital zika virus disease cases - 50 u.s. states and the district of columbia, 2016. | zika virus is a flavivirus primarily transmitted to humans by aedes aegypti mosquitoes (1). zika virus infections also have been documented through intrauterine transmission resulting in congenital infection; intrapartum transmission from a viremic mother to her newborn; sexual transmission; blood transfusion; and laboratory exposure (1-3). most zika virus infections are asymptomatic or result in mild clinical illness, characterized by acute onset of fever, maculopapular rash, arthralgia, or non ... | 2018 | 29518067 |
| impacts of diurnal temperature and larval density on aquatic development of aedes aegypti. | the increasing range of aedes aegypti, vector for zika, dengue, chikungunya, and other viruses, has brought attention to the need to understand the population and transmission dynamics of this mosquito. it is well understood that environmental factors and breeding site characteristics play a role in organismal development and the potential to transmit pathogens. in this study, we observe the impact of larval density in combination with diurnal temperature on the time to pupation, emergence, and ... | 2018 | 29513751 |
| zika virus epidemiology in bolivia: a seroprevalence study in volunteer blood donors. | zika virus (zikv), was widely reported in latin america and has been associated with neuropathologies, as microcephaly, but only few seroprevalence studies have been published to date. our objective was to determine the seroprevalence amongst bolivian blood donors and estimate the future potential circulation of the virus. | 2018 | 29513667 |
| swift fabrication of ag nanostructures using a colloidal solution of holostemma ada-kodien (apocynaceae) - antibiofilm potential, insecticidal activity against mosquitoes and non-target impact on water bugs. | recent research in entomology and parasitology focused on the efficacy of green fabricated nanomaterials as novel insecticides. in this study, we synthesized poly-dispersed and stable silver nanoparticles (agnps) using the leaf extract of holostemma ada-kodien. the nanostructures were characterized by ultraviolet-visible spectroscopy, fourier-transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, energy dispersive x-ray, and x-ray diffraction analysis. t ... | 2018 | 29510358 |
| salivary factor ltrin from aedes aegypti facilitates the transmission of zika virus by interfering with the lymphotoxin-β receptor. | pathogens have co-evolved with mosquitoes to optimize transmission to hosts. mosquito salivary-gland extract is known to modulate host immune responses and facilitate pathogen transmission, but the underlying molecular mechanisms of this have remained unknown. in this study, we identified and characterized a prominent 15-kilodalton protein, ltrin, obtained from the salivary glands of the mosquito aedes aegypti. ltrin expression was upregulated in blood-fed mosquitoes, and ltrin facilitated the t ... | 2018 | 29507355 |
| transovarial transmission of dengue 1 virus in aedes aegypti larvae: real-time pcr analysis in a brazilian city with high mosquito population density. | transovarial transmission is among the reported factors able to influence environmental maintenance of dengue virus (denv). endemic areas with active transmission of dengue are suitable for studying transovarial transmission. brazil is a country where dengue is endemic and where denv-1 is the most common disease-related virus serotype. this study aimed to identify transovarial transmission of denv-1 in aedes aegypti larvae by reverse-transcriptase nested real-time polymerase chain reaction. betw ... | 2018 | 29505732 |
| screening of plant extracts and fractions on aedes aegypti larvae found in the state of mato grosso do sul (linnaeus, 1762) (culicidae). | the constant use of chemical insecticides for aedes aegypti control has caused resistance in the mosquito populations. thus, the objective of this study was to analyze the larvicidal potential of extracts and fractions of plants on a. aegypti larvae. the analysis included sixty one extracts and twenty five fractions of fifty botanical species at concentrations of 0.25; 0.12; 0.06 to 0.03 mg ml-1; 4 replications and one negative control of dechlorinate water and 1% dmso; and a positive control wi ... | 2018 | 28640344 |
| quantification through tlc-densitometric analysis, repellency and anticholinesterase activity of the homemade extract of indian cloves. | the rise of the mosquitoes-transmitted diseases, like dengue, zika and chikungunya in brazil in the last years has increased concerns on protection against mosquitoes bites. however, the prohibitive prices of the commercially available repellents for the majority of the brazilian population has provoked a search for cheaper solutions, like the use of the homemade ethanolic extract of indian clove (syzygium aromaticum l.) as repellent, which has been reported as quite efficient by the local press ... | 2018 | 28913959 |
| influence of location and distance of biogents sentinel™ traps from human-occupied experimental huts on aedes aegypti recapture and entry into huts. | a mark-release-recapture study was conducted to refine the "push-pull" strategy for controlling the dengue, chikungunya, and zika virus vector aedes aegypti in a peridomestic environment by determining optimal locations and distances from human-occupied experimental huts for placement of the "pull" component (biogents sentinel™ [bgs] traps) to maximize the capture of mosquitoes. the bgs traps were placed at portals of entry (windows or doors) or corners of the experimental huts and at varying di ... | 2018 | 31442172 |
| habitat characteristics for immature stages of aedes aegypti in zanzibar city, tanzania. | aedesaegypti is the main vector for dengue, chikungunya, yellow fever, zika, and other arboviruses of public health importance. the presence of ae. aegypti has never been systematically assessed in zanzibar, including its preferred larval habitats. in 2016 we conducted a cross-sectional entomological survey to describe the preferred larval habitats of ae. aegypti in zanzibar city, the main urban area of the zanzibar archipelago. the surveys for container habitats were conducted for a 17-wk perio ... | 2018 | 31442169 |
| rapid immobilization of adult aedes aegypti caused by plant essential oils at sublethal concentrations. | many synthetic insecticides cause immobilization in insect pests after they are exposed. this immobilization or knockdown is an important feature of intoxication that contributes to the abatement of pest insect populations, while preventing vectors of disease from biting and spreading pathogenic organisms to susceptible individuals. we have previously demonstrated that certain plant essential oils rapidly immobilize adult female mosquitoes that have been exposed via topical application. to furth ... | 2018 | 31442168 |
| entomological investigation of aedes aegypti in neighborhoods with confirmed human arbovirus infection in puerto rico. | the exotic arboviruses chikungunya (chikv) and zika (zikv) recently caused large outbreaks and continue to circulate in puerto rico, prompting entomological investigations at 9 locations with confirmed chikv- or zikv-infected human cases. adult mosquitoes were collected using the centers for disease control and prevention autocidal gravid ovitraps over a 14-day period at each site. mean female aedes aegypti captured per trap-week ranged from 13.47 per trap-week to 1.27 per trap-week. arbovirus-p ... | 2018 | 31442166 |
| repellent activity of carrot seed essential oil and its pure compound, carotol, against mosquitoes. | in our natural products screening program for mosquitoes, carrot seed essential oil showed high repellency. the gas chromatography (gc)/flame ionization detector and gc/mass spectrometry analysis of the essential oil revealed the presence of 47 compounds. carotol was more than 75% w/w, followed by muurolene (4.86%), (z)-β-farnesene (2.9%), and diepicedrene (1.1%). systematic bioassay-guided fractionation of the essential oil was performed to identify active repellent compounds. in both klun and ... | 2018 | 31442148 |
| origin of aedes aegypti in clark county, nevada. | aedesaegypti is the primary vector for serious diseases, including those caused by chikungunya, dengue, and zika viruses. in 2017, the southern nevada health district first detected this invasive species in clark county, nv, including in the city of las vegas. we analyzed ae. aegypti from the city of north las vegas to determine the likely source of the invasion. we genotyped a sample of ae. aegypti at 12 highly variable microsatellites and analyzed the data in reference to published data from 2 ... | 2018 | 31442147 |
| scaled deployment of wolbachia to protect the community from dengue and other aedes transmitted arboviruses. | background: a number of new technologies are under development for the control of mosquito transmitted viruses, such as dengue, chikungunya and zika that all require the release of modified mosquitoes into the environment. none of these technologies has been able to demonstrate evidence that they can be implemented at a scale beyond small pilots. here we report the first successful citywide scaled deployment of wolbachia in the northern australian city of townsville. methods: the wmel strain of ... | 2018 | 30596205 |
| effects of multiple transmission pathways on zika dynamics. | although the zika virus is transmitted to humans primarily through the bite of infected female aedes aegypti mosquitoes, it can also be sexually and vertically transmitted within both populations. in this study, we develop a new mathematical model of the zika virus which incorporates sexual transmission in humans and mosquitos, vertical transmission in mosquitos, and mosquito to human transmission through bites. analysis of this deterministic model shows that the secondary transmission routes of ... | 2018 | 30839920 |
| green synthesis of copper oxide nanoparticles and mosquito larvicidal activity against dengue, zika and chikungunya causing vector aedes aegypti. | in the present study, high purity copper oxide nanoparticles (nps) were synthesised using tridax procumbens leaf extract. green syntheses of nano-mosquitocides rely on plant compounds as reducing and stabilising agents. copper oxide nps were characterised using x-ray diffraction (xrd) analysis, fourier transform infrared (ft-ir), field-emission scanning electron microscopy with energy dispersive spectroscopy, ultraviolet-visible spectrophotometry and fluorescence spectroscopy. xrd studies of the ... | 2018 | 30964011 |
| [communication for arboviral disease prevention: tailoring paho initiatives to the cuban contextcomunicação para prevenção de arboviroses: adequação das iniciativas da opas ao contexto cubano]. | the purpose of this paper is to describe the opportunities and challenges of training processes in the coordination of regional and national communication initiatives for arboviral disease prevention, using the lessons learned in the cuban context as an example. in february 2016 and december 2017, professional staff from the pedro kourí institute of tropical medicine attended workshops for strengthening communication capacities for arboviral disease prevention in primary health care settings thr ... | 2018 | 31093174 |
| [current distribution and bioecological characterizations of aedes aegypti and aedes albopictus in brazzaville]. | aedes aegypti is a mosquito that has been known in congo for decades. it has always been involved in the transmission of some arboviruses. ae. albopictus is an invasive species native from asia. its presence was reported in congo in 2009. the proliferation of ae. albopictus, especially in brazzaville, in association with ae. aegypti, have increased the risk of arbovirus transmission. the distribution and bio-ecology of these two species remain poorly studied. we undertook entomological investiga ... | 2018 | 30950593 |
| variation in wolbachia effects on aedes mosquitoes as a determinant of invasiveness and vectorial capacity. | wolbachia has been introduced into aedes aegypti mosquitoes to control the spread of arboviruses, such as dengue, chikungunya and zika. studies showed that certain wolbachia strains (such as wmel) reduce replication of dengue viruses in the laboratory, prompting the release of mosquitoes carrying the bacterium into the field, where vectorial capacity can be realistically assessed in relation to native non-carriers. here we apply a new analysis to two published datasets, and show that wmel increa ... | 2018 | 29662096 |
| numerical modeling of mosquito population dynamics of aedes aegypti. | the global incidences of dengue virus have increased the interest in studying and understanding the mosquito population dynamics. it is predominantly spread by aedes aegypti in the tropical and sub-tropical countries in the world. understanding these dynamics is important for public health in countries where climatic and environmental conditions are favorable for the propagation of these diseases. for this reason, a new model has been proposed to investigate the population dynamics of mosquitoes ... | 2018 | 29661212 |
| factors related to aedes aegypti (diptera: culicidae) populations and temperature determine differences on life-history traits with regional implications in disease transmission. | aedes aegypti (l.) (diptera: culicidae) is a vector of many medically significant viruses in the americas, including dengue virus, chikungunya virus, and zika virus. traits such as longevity, fecundity, and feeding behavior contribute to the ability of ae. aegypti to serve as a vector of these pathogens. both local environmental factors and population genetics could contribute to variability in these traits. we performed a comparative study of ae. aegypti populations from four geographically and ... | 2018 | 29659944 |
| detection of aedes (stegomyia) aegypti (diptera: culicidae) populations in southern alabama following a 26-yr absence and public perceptions of the threat of zika virus. | with the establishment of zika virus in the americas, an accurate understanding of the geographic range of its primary vector, aedes (stegomyia) aegypti (l.) (diptera: culicidae), is vital to assessing transmission risk. in an article published in june 2016, hahn and colleagues compiled county-level records in the united states for the presence of ae. aegypti and aedes (stegomyia) albopictus (skuse) (diptera: culicidae) reported between january 1995 and march 2016. despite ecological suitability ... | 2018 | 29659928 |
| coinfection with zika virus (zikv) and dengue virus results in preferential zikv transmission by vector bite to vertebrate host. | several tropical cities are permissive to aedes aegypti and dengue virus (denv) endemicity and have allowed for invasion and circulation of zika virus (zikv) in the same areas. people living in arbovirus-endemic regions have been simultaneously infected with ≥2 arboviruses. | 2018 | 29659904 |
| current and future distribution of aedes aegypti and aedes albopictus (diptera: culicidae) in who eastern mediterranean region. | aedes-borne diseases as dengue, zika, chikungunya and yellow fever are an emerging problem worldwide, being transmitted by aedes aegypti and aedes albopictus. lack of up to date information about the distribution of aedes species hampers surveillance and control. global databases have been compiled but these did not capture data in the who eastern mediterranean region (emr), and any models built using these datasets fail to identify highly suitable areas where one or both species may occur. the ... | 2018 | 29444675 |
| a point mutation v419l in the sodium channel gene from natural populations of aedes aegypti is involved in resistance to λ-cyhalothrin in colombia. | resistance to pyrethroids in mosquitoes is mainly caused by target site insensitivity known as knockdown resistance (kdr). in this work, we examined the point mutations present in portions of domains i, ii, iii, and iv of the sodium channel gene in aedes aegypti mosquitoes from three colombian municipalities. a partial region coding for the sodium channel gene from resistant mosquitoes was sequenced, and a simple allele-specific pcr-based assay (as-pcr) was used to analyze mutations at the popul ... | 2018 | 29443870 |
| analysis of peptide ligand specificity of different insect adipokinetic hormone receptors. | adipokinetic hormone (akh) is a highly researched insect neuropeptide that induces the mobilization of carbohydrates and lipids from the fat body at times of high physical activity, such as flight and locomotion. as a naturally occurring ligand, akh has undergone quite a number of amino acid changes throughout evolution, and in some insect species multiple akhs are present. akh acts by binding to a rhodopsin-like g protein-coupled receptor, which is related to the vertebrate gonadotropin-releasi ... | 2018 | 29439466 |
| functional characterization and quantitative expression analysis of two gnrh-related peptide receptors in the mosquito, aedes aegypti. | to cope with stressful events such as flight, organisms have evolved various regulatory mechanisms, often involving control by endocrine-derived factors. in insects, two stress-related factors include the gonadotropin-releasing hormone-related peptides adipokinetic hormone (akh) and corazonin (crz). akh is a pleiotropic hormone best known as a substrate liberator of proteins, lipids, and carbohydrates. although a universal function has not yet been elucidated, crz has been shown to have roles in ... | 2018 | 29432729 |
| history dependence in insect flight decisions during odor tracking. | natural decision-making often involves extended decision sequences in response to variable stimuli with complex structure. as an example, many animals follow odor plumes to locate food sources or mates, but turbulence breaks up the advected odor signal into intermittent filaments and puffs. this scenario provides an opportunity to ask how animals use sparse, instantaneous, and stochastic signal encounters to generate goal-oriented behavioral sequences. here we examined the trajectories of flying ... | 2018 | 29432454 |
| carica papaya (papaya) latex: a new paradigm to combat against dengue and filariasis vectors aedes aegypti and culex quinquefasciatus (diptera: culicidae). | this study manifests the larvicidal efficacy of carica papaya latex extract and silver nanoparticles (cpagnps) synthesized using latex, against developing immature juveniles of aedes aegypti and culex quinquefasciatus. briefly, the latex was collected and fractioned with different solvents such as chloroform, methanol and aqueously. the obtained crude extracts were subjected to larvicidal activity in the dose-dependent method. after 24 h, the mortality rate was calculated and statistically analy ... | 2018 | 29430347 |
| re-emergence of aedes aegypti in egypt. | 2018 | 29412959 | |
| entomopathogenic fungi and their potential for the management of aedes aegypti (diptera: culicidae) in the americas. | classical biological control has been used extensively for the management of exotic weeds and agricultural pests, but never for alien insect vectors of medical importance. this simple but elegant control strategy involves the introduction of coevolved natural enemies from the centre of origin of the target alien species. aedes aegypti - the primary vector of the dengue, yellow fever and zika flaviviruses - is just such an invasive alien in the americas where it arrived accidentally from its west ... | 2018 | 29412361 |
| the influence of a light and dark cycle on the egg laying activity of aedes aegypti (linnaeus, 1762) (diptera: culicidae). | the epidemiological importance of the mosquito aedes aegypti as a vector of multiple human pathogens has generated a growing number of studies on the physiology and behaviour of its blood-feeding females. the activity of oviposition is one of the critical elements contributing to the expansion of ae. aegypti's populations. although there is a vast literature about oviposition behaviour, significant specific knowledge about egg viability and female fertility under light and dark conditions is sti ... | 2018 | 29412343 |
| clinical and epidemiological teaching of dengue through simulated practice. | to describe the experience of clinical teaching on dengue and the practice of epidemiological surveillance using problematization methodology. | 2018 | 29412306 |
| [eradication of aedes aegypti: new perspectives on international health cooperation in the americas]. | 2018 | 29412266 | |
| context-dependent interactive effects of non-lethal predation on larvae impact adult longevity and body composition. | predation impacts development, behavior and morphology of prey species thereby shaping their abundances, distribution and community structure. non-lethal threat of predation, specifically, can have a strong influence on prey lifehistory characteristics. while investigations often focus on the impact of predation threat on prey in isolation, tests of its interactive effects with food availability and resource competition on prey survival and fitness can improve understanding of costs, benefits an ... | 2018 | 29401513 |
| molecular identification, transcript expression, and functional deorphanization of the adipokinetic hormone/corazonin-related peptide receptor in the disease vector, aedes aegypti. | the recently discovered adipokinetic hormone/corazonin-related peptide (acp) is an insect neuropeptide structurally intermediate between corazonin (crz) and adipokinetic (akh) hormones, which all demonstrate homology to the vertebrate gonadotropin-releasing hormone (gnrh). to date, the function of the acp signaling system remains unclear. in the present study, we molecularly identified the complete open reading frame encoding the aedes aegypti acp receptor (acpr), which spans nine exons and unde ... | 2018 | 29391531 |
| [the recent epidemic spread of zika virus disease]. | zika virus (zikv) is one of the members of the spondweni serocomplex within the genus flavivirus of the family flaviviridae. the virus was first isolated from a serum specimen from a sentinel non-human primate in the zika forest of uganda in 1947. zikv is transmitted by aedes aegypti and a. albopictus in an urban cycle and maintained in a sylvatic cycle between aedes mosquitoes and monkeys in africa and asia. initially, the virus was thought to cause only mild and nonspecific clinical symptoms i ... | 2018 | 31105130 |
| erratum to "comparative oviposition site selection in containers by aedes aegypti and aedes albopictus (diptera: culicidae) from florida". | 2018 | 29618025 | |
| a comparative analysis of corpora allata-corpora cardiaca microrna repertoires revealed significant changes during mosquito metamorphosis. | the corpora allata (ca) are a pair of endocrine glands with neural connections to the brain and close association with another neuroendocrine organ, the corpora cardiaca (cc). the ca from adult female aedes aegypti mosquitoes synthesize fluctuating levels of juvenile hormone (jh), which have been linked to the ovarian development and are influenced by nutritional signals. in this study, we investigated the potential involvement of micrornas (mirnas), a type of small non-coding rnas, in the regul ... | 2018 | 29605533 |
| mosquito responses to trait- and density-mediated interactions of predation. | mosquito and predatory larvae often share the same habitat. predators may influence mosquito prey populations through both lethal effect and non-lethal pathways. a series of experimental manipulations were used to distinguish between lethal (density-mediated interaction) and non-lethal (trait-mediated interaction) effects in a model system comprised of invasive prey mosquito, aedes aegypti, and a predatory mosquito toxorhynchites rutilus. treatments with predators present or manipulations mimick ... | 2018 | 29594613 |
| effect of relaxation of deltamethrin pressure on metabolic resistance in a pyrethroid-resistant aedes aegypti (diptera: culicidae) strain harboring fixed p989p and g1016g kdr alleles. | mutation of the voltage-gated sodium channel genes or knockdown resistance (kdr) and metabolic resistance in aedes aegypti (l.) (diptera: culicidae) are important resistance mechanisms against pyrethroids. the present study investigated the effect of relaxation of deltamethrin selection pressure on the level of mixed-function oxidases (mfo), when the allele frequency of s989p+v1016g mutations is fixed in a resistant ae. aegypti strain (upk-r) from chiang mai, thailand. the mosquitoes were divide ... | 2018 | 29590378 |
| maternal invasion history of aedes aegypti and aedes albopictus into the isthmus of panama: implications for the control of emergent viral disease agents. | despite an increase in dengue outbreaks and the arrival of chikungunya and zika disease in panama, studies on the demographic history of the invasive aedes mosquitoes that are the principle vectors of these diseases are still lacking in this region. here, we assess the genetic diversity of these mosquitoes in order to decipher their invasion histories into the isthmus of panama. dna sequences from the mitochondrial cytochrome c oxidase i gene obtained from 30 localities in 10 provinces confirmed ... | 2018 | 29579112 |
| frequency and intensity of pyrethroid resistance through the cdc bottle bioassay and their association with the frequency of kdr mutations in aedes aegypti (diptera: culicidae) from mexico. | the control of aedes aegypti (l.), the main urban vector that causes arboviral diseases such as dengue, chikungunya and zika, has proved to be a challenge because of a rapid increase in insecticide resistance. therefore, adequate monitoring of insecticide resistance is an essential element in the control of ae. aegypti and the diseases it transmits. we estimated the frequency and intensity (resistance frequency rapid diagnostic test [f-rdt] and resistance intensity rapid diagnostic test [i-rdt]) ... | 2018 | 29575404 |
| population dynamics of engineered underdominance and killer-rescue gene drives in the control of disease vectors. | a number of different genetics-based vector control methods have been proposed. two approaches currently under development in aedes aegypti mosquitoes are the two-locus engineered underdominance and killer-rescue gene drive systems. each of these is theoretically capable of increasing in frequency within a population, thus spreading associated desirable genetic traits. thus they have gained attention for their potential to aid in the fight against various mosquito-vectored diseases. in the case ... | 2018 | 29570717 |
| repellent activity of trig (n-n diethyl benzamide) against man-biting mosquitoes. | a study was conducted to assess efficacy of a new repellent brand trig (15% n-n diethyl benzamide) when compared to deet (20% n-n methyl toluamide). the repellents were tested in laboratory and field. in the laboratory, the repellence was tested on human volunteers, by exposing their repellent-treated arms on starved mosquitoes in cages for 3 minutes at hourly intervals, while counting the landing and probing attempts. anopheles gambiae and aedes aegypti mosquitoes were used. field evaluation wa ... | 2018 | 29552040 |
| hr38, an ortholog of nr4a family nuclear receptors, mediates 20-hydroxyecdysone regulation of carbohydrate metabolism during mosquito reproduction. | the aedes aegypti mosquito is the principal vector for many dangerous human viral diseases. carbohydrate metabolism (cm) is essential for supplying the energy necessary for host seeking, blood digestion and rapid egg development of this vector insect. the steroid hormone 20-hydroxyecdysone (20e) and the ecdysone receptor (ecr) are important regulators of cm, coordinating it with female reproductive events. we report here that the nr4a nuclear receptor ahr38 plays a critical role in mediating the ... | 2018 | 29526770 |