Publications

the encapsulation process in biomphalaria glabrata experimentally infected with the metastrongylid angiostrongylus cantonensis: enzyme histochemistry.		1975	1206232
the first authentic record of angiostrongylus cantonensis chen, 1935 peninsular malaysia.	angiostrongylus cantonensis chen, was recovered from a field rat, rattus tiomanicus from the east coast of peninsular malaysia. the parasite constitutes the first reported record occurring in this country. morphological character of the parasite are compared with the original description of a. cantonensis by chen (1935), a. cantonensis from formosa and a. malaysiensis from malaysia.	1975	1221505
presence of angiostrongylus cantonensis at la réunion.	the eosinophilic meningitis due to angiostrongylus cantonensis is well known on madagascar and on mauritius island, but was never described on reunion island. two cases have been lately oberved in doctor jay's department at gabriel martin's hospital. local achatines were dissected and contained larvae which, when absorbed by rats, were found in there brains ten days later. these larvae belong certainly to angiostrongylus genus, but the species has not yet been found with certitude. lately infest ...	1975	7126
incorporation of exogenous d-glucose-1-(14)c and d-manose-1-(14)c into glycogen and lactate excreted by angiostrongylus cantonensis in vitro.	the amount of labelled glucose incorporated into glycogen is 6 times as much as that of labelled mannose by the female worms. they excreted lactate of labelled glucose-origin 3-4 times as much as that of labelled mannose-origin. the amount of labelled glucose incorprated in worm bodies is about 3 times as much as that of labelled mannose. male worms absorbed a half amount of glucose by female worms. paralelled with radioactivity studies mentioned above, chemical determinations of sugars, lactate ...	1975	12913465
[histological studies of the african giant snail (achatina fulica) experimentally infected with angiostrongylus vasorum or angiostrongylus cantonensis (author's transl)].	african giant snails (achatina fulica) about 6 weeks old were experimentally infected with each 5,000 to 20,000 first stage larvae of angiostrongylus vasorum or a. cantonensis by exposure to a larval suspension. the snails were histologically examined after various intervals after infection: 1 hour post infectionem (p.i.) larvae were present in the foot and 2 hours p.i. in addition in the gastrointestinal tract. 12 hours p.i. larvae were seen for the first time in the lung which reached nearly h ...	1976	790803
eosinophilic meningoencephalitis caused by the rat lung worm, angiostrongylus cantonensis with special reference to a. malaysiensis in malaysia.		1976	822262
letter: granulomatous encephalomyelitis of puppies due to angiostrongylus cantonensis.		1976	971151
reaginic antibody productions in rabbits and rats infected with angiostrongylus cantonensis.		1976	985982
growth and localization of angiostrongylus cantonensis in the molluscan host, achatina fulica.	the development of the rat lung worm angiostrongylus cantonensis within the giant african snail achatina fulica is reported. in this host, ingested first stage larvae penetrate the intestinal wall into the hemocoel and migrate to the mantle where they undergo two molts and become third stage larvae within 24 days. the mantle, harboring 85% of the total number recovered is the major location of infective larvae. the kidney contains about 11% but few larvae are found in the remaining visceral org ...	1976	1027104
the bandicoot rat, a new host record for angiostrongylus cantonensis in indonesia.	a survey for angiostrongylus cantonensis in possible definitive and intermediate hosts was conducted in ancol, jakarta. adult worms were found in 43% of bandicoot rats, bandicota indica setifera, in 14% of rattus rattus diardii and 36% of the achatina fulica were infected with larval forms of the parasite. the finding of the parasite in the bandicoot rat constitutes a new host record for indonesia.	1976	1027106
delayed hypersensitivity responses of guinea pig and rat to angiostrongylus cantonensis infection.		1976	1034844
[presence of angiostrongylus cantonensis in the réunion island. isolation of the strain].	the detection of some cases of eosinophilic meningitis suggest that angiostrongylus cantonensis is present in reunion island. larvae of this nematode have been isolated after dissection of achatina fulica and have been used to infest laboratory rats. 30 days later, the dissection of these animals shows the presence of young worms in the brain and in the pulmonary arteries. 45 days later, first-stage larvae are recovered from the feces of animals. now, the strain is maintained in biomphalaria gla ...	1976	1037434
angiostrongylus cantonensis in rats on makung, pescadores islands (peng hu).		1976	1037538
angiostrongylus cantonensis: lymphoid cell responsiveness and antibody production in rats.	angiostrongylus cantonensis-infected rats were examined for the presence of antigen sensitive lymphocytes, as assessed by the in vitro uptake of tritiated thymidine by cells of various lymphoid organs (cervical, mediastinal and mesenteric lymph nodes, spleen and periphereal blood), following stimulation by adult worm antigen. the lymphoid cell response of rats to a. cantonensis appeared to be local in nature in that significant responses were noted only in the cervical lymph node cells during th ...	1976	1259083
clinical observations on eosinophilic meningitis and meningoencephalitis caused by angiostrongylus cantonensis on taiwan.	one hundred and twenty-five patients with eosinophilic meningitis or meningoencephalitis were studied in southern taiwan in 1968 and 1969. the majority of patients had mild to moderate disease, but several had severe manifestations. four patients died and three others had severe permanent sequelae such as blindness. young adult angiostrongylus cantonensis were recovered from nine patients, at autopsy in one, and from the cerebrospinal fluid of eight who survived. the clinical manifestations of c ...	1976	1259085
host-parasite relationship of angiostrongylus cantonensis in lymnaea palustris. ii. histopathology.		1976	1269582
host-parasite relationship of angiostrongylus cantonensis in lymnaea palustris. iii. oxygen uptake of lymnaea palustris.		1976	1269583
[1st case of eosinophilic meningitis in reunion, probably due to angiostrongylus].	report of the case of a six-year-old child who presented a meningitis with 40 % eosinophils in the cerebrospinal fluid and which spontaneously regressed. these clinical data and the serologic (positive test for many nematod antigens) and epidemiological findings (presence of angiostrongylus larvae in terrestrial gasteropod) lead to the conclusion that we were in presence of the first case of eosinophil meningitis due to angiostrongylus cantonensis reported in the island of la réunion.	1977	579615
[development of angiostrongylus cantonensis in the lung of achatina fulica (author's transl)].	twenty-four achatina fulica from pai-sha of the pescardores islands, where no angiostrogylus cantonensis has been found in a. fulica(4), were inoculated with the first stage larvae of a cantonensis. one snail was killed every day after 24 days following inoculation. the lung of each snail was separated and examined for larvae under microscope. the same lung was then digested with pepsin. the larvae recovered after pepsin digestion were examined for more detailed morphology. this study confirmed ...	1977	580235
commercially available, edible snails otala lactea (müller) and helix aperta (born) as laboratory hosts of angiostrongylus cantonensis.		1977	592047
epidemiological survey of angiostrongylus cantonensis in shimizu ship-port, shizuoka prefecture, japan.		1977	598977
experimental double infection of biomphalaria glabrata snails with angiostrongylus cantonensis and schistosoma mansoni.	two groups of biomphalaria glabrata snails primarily infected with angiostrongylus contonensis were secondarily exposed to infection with schistosoma mansoni. to investigate any anatagonistic effect of the first infection on a superimposed one and to compare to singly and non-infected snails, a series of experiments was undertaken in which snails were individually exposed, variously, to 1,000 and 2,000 first-stage larvae of a. cantonensis and then to 5 and 10 miracidia of s. mansoni 1 day and 3 ...	1977	605654
effect of immunization with metabolic antigens on experimental infection of rats with angiostrongylus cantonensis.	immunization of rats with excretions and secretions from an in vitro culture fluid (es antigens) of adult female angiostrongylus cantonensis markedly enhanced their resistance to infection by third-stage larvae. mortality rate, survival period, worm development and worm recovery, determined after a lethal challenge with infective larvae, were compared in immunized and unimmunized animals. with regard to these criteria, the results obtained with animals that had been immunized with es antigens fr ...	1977	614709
angiostrongylus cantonensis: phospholipase in nonsensitized and sensitized rats after challenge.	rats given an initial infection with angiostrongylus cantonensis had moderately elevated phospholipase b activity in the lungs at 8 and 15 days after challenge, and greatly elevated levels were evident at 35, 43, and 49 days. in the brain, the values were elevated at 15 through 35 days. these periods of increased activity in the lungs and brain coincided with the migration patterns of the third stage larvae and the adult worms in this host. the elevated enzyme levels also were were correlated wi ...	1977	832897
ocular angiostrongyliasis in semarang, central java.	a worm removed intact from the anterior chamber of the left eye of a 23-year-old woman from central java was identified as a mle angiostrongylus cantonensis, 11.1 mm in length and 0.24 mm in maximum width. a useful degree of eye function was preserved. five similar cases have been reported--three from thailand, two from south vietnam.	1977	842785
the mode of infection with and the distribution of angiostrongylus cantonensis larvae in the experimental intermediate hoist biomphalaria glabrata.		1977	919700
nematode parasites of rats in west java, indonesia.	from the indonesian rats, namely rattus rattus diardii, r. exulans, r. tiomanicus, r. niviventer, r. lepturus, r. bartelsii, r. cremoriventer, r. sabanus and pithecheir melanurus, surveyed for nematode parasites, the following parasites were recovered: angiostrongylus cantonensis, capillaria hepatica, cyclodontostomum purvisi, hepatojarakus malayae, rictularia tani, mastophorus muris, physaloptera sp. and subulura andersoni. of these, c. purvisi, h. malayae, physaloptera, sp. and s. andersoni ha ...	1978	571622
"commercially available, edible snails otala lactea (müller) and helix aperta (born) as laboratory hosts of angiostrongylus cantonensis".		1978	627973
acetylcholinesterase levels in angiostrongylus cantonensis in relation to the immune response in rats.		1978	631982
nidality of eosinophilic meningitis with special reference to angiostrongylus cantonensis.		1978	632707
angiostrongylus cantonesis infection of the brain of a captive bennett's wallaby (macropus rufogriseus).	eleven immature adult angiostrongylus cantonensis were recovered from beneath the meninges of a captive bennett's wallaby (macropus rufogriseus) which died after displaying posterior paresis followed by paralysis and intermittent opisthotonic spasms of increasing frequency for 7 days. congestion and focal malacia with haemorrhage were seen in the brainstem and cerebellum. sections of worms with scanty inflammatory response were seen beneath the congested haemorrhagic leptomeninges of cerebrum an ...	1978	655984
the first record of angiostrongylus cantonensis from egypt.	in this paper the first record of the medically important nematode parasite, angiostrongylus cantonensis, is made from egypt. a survey of eight species of freshwater gastropods collected from natural water courses and of three species of wild rats caught from the same areas revealed respectively, that the ampullarid snail lanistes carinatus acts as the intermediate host transmitting this parasite, and that the rat rattus norvegicus is its definitive host. the life cycle of the parasite was succe ...	1978	706552
[eosinophilic meningoencephalitis caused by angiostrongylus cantonensis: a case report (author's transl)].		1978	709966
transplantation of intracranial young adult angiostrongylus cantonensis into the subdural spaces of the brains of rats and guinea pigs.		1978	713222
observations on the development of angiostrongylus cantonensis in mastomys and mongolian gerbils.		1978	723108
effects of parasitism and stress on hemolymph protein of the african giant snail, achatina fulica.	effects of parasitism and stress on the protein concentration of hemolymph have been investigated using the rat lungworm angiostromgylus cantonensis in the snail host achatina fulica. the normal hemolymph protein concentration, averaging 1.77 g/100 ml in noninfected snails, did not show any reduction when the hosts were infected with third stage larvae. when the infected snails were bled repeatedly, protein concentration showed a significant decrease by 0.6 g/100 ml. starved, infected snails wer ...	1978	735303
angiostrongyliasis in indonesia: additional geographic and host occurrence records.	geographical and host occurrence records for angiostrongylus cantonensis throughout the indonesian archipelago a;e reported. a. cantonensis was found in the following provinces: west sumatra, south sumatra, lampung, west java, central java, north sulawesi and east nusa tenggara. infections were diagnosed in the following rodents: rattus rattus diardii, rattus exulans, rattus tiomanicus jaloriensis, rattus lepturus, rattus norvegicus and bandicota indica setifera and in the giant african land sna ...	1978	751218
parasitic diseases of the nervous system in thailand.	in thailand there are 3 parasites that commonly cause neurological diseases in man. 1) in gnathostomiasis man becomes an accidental host by eating infected under-cooked fresh water fish. the tissue nematode involved, gnathostoma spinigerum, because of its high motility, may cause widespread damage in the spinal cord and brain stem. the common presenting neurological symptoms are severe nerve root pain, paralysis of limbs and urinary retention. less frequently seen are cranial nerve palsies and s ...	1978	756025
the humoral and cell-mediated immune responses to somatic and metabolic antigens in rats infected with angiostrongylus cantonensis.		1978	86211
occurrence of angiostrongylus cantonensis in the heart of a spider monkey.		1978	102677
effects of various numbers of adult angiostrongylus cantonensis on lung lysophospholipase activities and bone marrow eosinophil levels of specific pathogen-free rats.		1978	153956
eosinophilic meningitis in tahiti: clinical study of 54 patients.	eosinophilic meningitis is due to infestation of the nervous system by the larvae of angiostrongylus cantonensis. the infection is from infected prawns and slugs. in a study of 54 patients from tahiti the leading symptoms were headaches, neck stiffness, limb pains and sometimes a facial palsy. the diagnosis is made by examination of the csf when the leucocytes are usually over 100/mm3 and over half are eosinophilic cells. the blood eosinophil count is often raised, above 400/mm3. the disease is ...	1978	283329
immunodiagnosis of parasitic zoonoses: comparative efficacy of three immunofluorescence tests using antigens purified by affinity chromatography.	three immunofluorescent antibody assays were developed during this study: the direct (dfat) and indirect (ifat) fluorescent antibody tests using frozen worm sections, and the cyanogen bromide indirect fluorescent antibody test (cnbr-ifat) using helminth antigens purified by affinity chromatography bound on to commercially prepared cnbr-sepharose 4b beads. purified antigens used in the cnbr-ifat gave greater specificity and sensitivity than either the dfat or ifat. dirofilaria immitis, toxocara c ...	1978	354114
food-borne parasitic infections--old stories and new facts.	a review is presented of food-borne parasitic infections. parasitic infections with public health hazards both from conventional slaughter animals and from seafood (fish and shellfish) are discussed. the former category includes cysticercosis, echinococcosis, and trichinosis, the latter category covers various trematode, cestode, nematode, and possibly also protozoan infections. examples of trematode infections are heterophyidiasis, transmitted to man by marine fish, and paragonimus spp parasite ...	1979	369034
eosinophilic meningitis: a suspected case of angiostrongylosis found in shizuoka prefecture, honshu, japan.	a patient with eosinophilic meningitis in shizuoka prefecture, honshu, japan had nausea, vomiting and headache on admission; laboratory examinations revealed leukocytosis with eosinophilia. eight days later neck stiffness appeared. lumbar puncture showed an increase of the initial pressure in association with eosinophilic pleocytosis in the spinal fluid. the possibility of angiostrongylosis was considered because the patient had eaten raw slugs for 4 years as a remedy for lumbago. although the s ...	1979	434313
transplantation of young adult angiostrongylus cantonensis into the rat pulmonary vessels and its application to the assessment of acquired resistance.		1979	437939
changes in worm burden, haematological and serological response in rats after single and multiple angiostrongylus cantonensis infections.	thirteen groups of rats were first sensitized with single or double doses of 5--30 third-stage larvae of angiostrongylus cantonensis, followed by a challenge infection with 100 larvae at various periods after the primary infection. seven other groups of rats receiving only the sensitizing infection served as the controls. in all the sensitized rats, a significantly (p less than 0.05) smaller mean number of adult worms was found established in the challenge infection as compared to the control. t ...	1979	452645
recovery of angiostrongylus cantonensis from cerebrospinal fluid of a child with eosinophilic meningitis.	viable angiostrongylus cantonensis was recovered from the cerebrospinal fluid of a 17-month-old boy with eosinophilic meningitis. neurological findings were minimal, and the child had an uneventful recovery.	1979	479360
host-parasite relationship of angiostrongylus cantonensis. 1. intracranial transplantation into various hosts.	various stages of angiostrongylus cantonensis recovered from the brain of experimentally infected mice were transplanted intracranially into rats. third and fourth-stage worms recovered 2--7 days postinfection were able to develop normally after transplantation into recipient rats. the fifth-stage worm obtained 14--15 days postinfection would enter the brain tissue of rats but died shortly afterwards. however, the same stage of worms recovered from rats, after a similar transplantation, were fou ...	1979	479541
effect of vitamin a deficiency on susceptibility of rats to angiostrongylus cantonensis.		1979	482296
angiostrongylus cantonensis: infectivity of first stage larvae in the presence of rat fecal materials as tested by the in vitro cultivation technique.		1979	483014
cross-resistance between trichinella spiralis and angiostrongylus cantonensis in laboratory rats.		1979	494711
studies on susceptibility of pila ampullacea, to the infection with the rat lungworm, angiostrongylus cantonensis.	experimental infections of pila ampullacea with first stage larvae of angiostrongylus cantonensis were carried out to determine susceptibility of this molluscan host in relation to dose level and snail host size. snails were divided into 3 size groups and exposed to a. cantonensis first stage larval suspensions of varying concentrations. the results showed that overall, about 20% of larvae ingested by the snails developed into infective third stage larvae, but the percentage was inversely relate ...	1979	538501
acquired resistance and immune responses of eight strains of inbred rats to infection with angiostrongylus cantonensis.		1979	314012
hexokinase of angiostrongylus cantonensis: presence of a glucokinase.	1. angiostrongylus cantonensis contains a glucokinase which was isolated by deae-cellulose column chromatography. 2. this enzyme has a much higher affinity toward glucose (apparent km, 0.2 mm) than fructose (apparent km, 85 mm). glucose-6-phosphate (10 mm) does not inhibit glucose phosphorylation. 3. molecular weight obtained by a molecular sieve chromatography (60,000) is also close to the value of mammalian glucokinase. 4. while vmax value for mannose is one-third smaller than that for glucose ...	1979	318415
de novo purine ribonucleotide biosynthesis in adult angiostrongylus cantonensis (nematoda: metastrongyloidea).	1. radioactivity was found to be associated with purine ribonucleotides in extracts of gravid adult angiostrongylus cantonensis from the lungs of rats when the parasite was incubated in a medium containing [14c]glycine. 2. the rate of incorporation was at least 0.2 pmole/min per mg of parasite and approximately equal amounts of adenine and guanine ribonucleotides were synthesized. 3. this is the first demonstration of the capacity for a mammalian parasitic helminth to synthesize purines de novo.	1979	318440
clinical manifestations of eosinophilic memingitis due to angiostrongylus cantonensis.	between 1959 and 1976, 34 patients were seen in hawaii with eosinophilic meningitis. angiostrongylus cantonensis was recovered from two of these patients. the remaining cases were presumed to be due to this parasite because of clinical and epidemiologic findings. the most likely source of infection for eight patients was ingesting raw terrestrial snails or slugs, and for six patients eating raw or poorly cooked crustaceans. patients typically presented with severe headache; neck stiffness and fe ...	1979	574219
acid phosphatase activity demonstrated by intact angiostrongylus cantonesis with special reference to its function.	intact angiostrongylus cantonensis is able to hydrolyse glucose-phosphate esters, mononucleotides and rho-nitrophenyl phosphate as well as beta-glycerophosphate in vitro. reciprocal inhibition studies suggest that the hydrolysis of such substrates is due to a non-specific phosphomonoesterase. molybdate ions, which exert no effect on either the uptake of glucose or the production of lactate, inhibit the hydrolysis of glucose-1-phosphate in the external medium and simultaneously lower the producti ...	1979	44361
food-borne parasitic infections - old stories and new facts.	summary a review is presented of food-borne parasitic infections. parasitic infections with public health hazards both from conventional slaughter animals and from seafood (fish and shellfis) are discussed. the former category includes cysticercosis, echinococcosis, and trichinosis, the latter category covers various trematode, cestode, nematode, and possibly also protozoan infections. examples of trematode infections are heterophyidiasis, transmitted to man by marine fish, and paragonimus ...	1979	22040471
immunodiagnosis and seroepidemiology of angiostrongylus cantonensis zoonoses in man.	the development of serum and cellular assays to measure responses to angiostrongylus cantonensis antigen, purified by affinity chromatography, formed the basis of this study. the specificity and sensitivity of these techniques were established in immunized rabbits and in naturally and laboratory-infected rats. the assays were then used to determine levels of immunological responsiveness to a. cantonensis in four australian populations. there was a direct correlation between the prevalence of the ...	1980	7010689
use of excretory and secretory products from adult female worms to immunize rats and mice against angiostrongylus cantonensis infection.	to evaluate their protective potential, excretions and secretions of adult female angiostrongylus cantonensis were prepared from an in vitro culture fluid and injected together with freund's complete and incomplete adjuvants into rats and mice. under appropriate conditions, judging from reduced mortality rates and/or prolonged survival periods, these animals were protected against a lethal challenge infection with 3rd-stage larvae. although both 'immunized' and unimmunized mice died following su ...	1980	6156433
tadpole of the clawed frog, xenopus laevis, as an experimental intermediate host of angiostrongylus cantonensis.	frogs and toads, as paratenic hosts, are known to be sources of human angiostrongyliasis. the present investigation was carried out to examine the role of the tadpole as an experimental intermediate host. first-, second-, and third-stage larvae were found in tadpoles of xenopus laevis from the 1st, 14th, and 18th days, respectively, after exposure to the first-stage larva of angiostrongylus cantonensis. third-stage larvae collected from a frog which had metamorphosed from an exposed tadpole reac ...	1980	7369450
angiostrongylus cantonensis: development following pulmonary arterial transfers into permissive and nonpermissive hosts.		1980	7371736
acid phosphatase activity demonstrated in the nematodes, dirofilaria immitis and angiostrongylus cantonensis with special reference to the characters and distribution.	acid phosphatase activity was demonstrated in the intact blood nematodes, dirofilaria immitis and angiostrongylus cantonensis. biochemical studies on acid phosphatase, using intact females and whole worm, body-wall and visceral homogenates were undertaken to clarify the characteristics and the distribution of the enzyme. in d. immitis, high acid phosphatase activity was observed at ph 3.8--5.8 and in a. cantonensis, at ph 4.5--6.0. molybdate, fluoride, copper and zinc ions and l(+)-tartate were ...	1980	7383707
the cellular responses in marisa cornaurietis experimentally infected with angiostrongylus cantonensis.	the cellular responses in the poorly susceptible ampullariid snail marisa cornaurietis to angiostrongylus cantonensis, during a period of 40 days, involved focal and generalized proliferative reactions. the focal reactions appeared around all larvae as accumulations of variable numbers of amoebocytes at 24 h after infection in the loose connective tissues and somewhat later in the dense tissues. this cellular infiltration intensified gradually with time leading to the encapsulation of the parasi ...	1980	7395311
carbohydrate reserves and hemolymph sugars of the african giant snail, achatina fulica in relation to parasitic infection and starvation.	in the snail, achatina fulica, parasitized by the rat lungworm angiostrongylus cantonensis, levels of carbohydrate in hemolymph and digestive glands were determined. the normal level of hemolymph glucose of 11.7 mg% dropped to 4.25 mg% in the infected snails, a significant difference after only one week of infection. the level of total reducing sugar in the hemolymph also decreased significantly (12.3 mg% to 3.6 mg%) in this period. later on, the snails were capable of adapting themselves to the ...	1980	7415419
phospholipase b in the brains and meninges of nonsensitized and sensitized rats after challenge with angiostrongylus cantonensis.	after a primary infection with 100 angiostrongylus cantonensis larvae, infected rats showed elevated phospholipase b activity in meningeal and brain homogenates beginning with the first week and continuing through the first month of infection. the rise in phospholipase b values through the first 4 weeks, with a prolonged peak spanning days 30 to 31, coincided with the invasion and maturation of the parasites in the brain, and the ensuing sharp decline in phospholipase b levels, shown by the read ...	1980	7216437
transfer of young adult angiostrongylus cantonensis from mastomys and mice to the pulmonary arteries of rats immunized against the donor hosts.		1980	7230566
experimental light infection of angiostrongylus cantonensis in hamsters.	an experimental infection with a small number of larvae of a. cantonensis in hamster was carried out. when hamsters were infected with one larva, infection rate and recovery rate were 66.7%. in the case of infection with more than two larvae, all hamsters were infected had recovery rates were around 65%. the recovered worms were all matured and showed no important morphological differences. it was concluded that the hamster would be able to serve as a final host for a. cantonensis only in the ca ...	1980	7251256
eosinophilic meningoencephalitis in cuba, caused by angiostrongylus cantonensis.	five cases of eosinophilic meningoencephalitis presumed to be caused by the rat lungworm, angiostrongylus cantonensis, are reported from localities in or near havana, cuba. the first typical case occurred in 1973. lungworms identified as a. cantonensis were found in rats from the same localities. the clinical picture in the cuban cases, as in cases from other countries, is that of a self-limiting disease without apparent sequelae.	1981	7283014
first record of angiostrongylus cantonensis in cuba.	the occurrence of human eosinophilic meningoencephalitis in several localities of havana, cuba, prompted a search for the rat lungworm, angiostrongylus cantonensis, in the same localities. twenty rats (rattus norvegicus) and about 370 terrestrial mollusks (70 slugs, veronicella cubensis, and about 300 snails, mostly bradybaena similaris) were collected in six communities of the province of havana, and in the gardens of the pedro kouri institute for tropical medicine in havana city. adult lungwor ...	1981	7283015
[two cases of natural infection of angiostrongylus cantonensis in cynomolgus monkeys (macaca fascicularis) (author's transl)].	two of 80 cynomolgus monkeys, macaca fascicularis, imported from indonesia showed weakness, anorexia, paralysis of extremities and dysstasia. the blood test conducted at the time of autopsy proved that the white blood cell count markedly decreased in both cases and the blood urea nitrogen content increased in case no. 1. in case no. 2, a high blood sugar value, a low red blood cell count and a low hematocrit value were recognized. histologic examinations revealed the presence of fragments of a n ...	1981	7318930
localized distribution of angiostrongylus cantonensis among wild rat populations in brisbane, australia.		1981	7344114
angiostrongylus cantonensis: rejection of pulmonary arterial transfers of lung stage worms.		1981	7461084
immunodiagnosis of parasitic zoonoses: sensitivity and specificity of in vitro lymphocyte proliferative responsiveness using nematode antigens purified by affinity chromatography.	the sensitivity of in vitro lymphocyte proliferative responsiveness using antigens purified by affinity chromatography, was greater than that of three serological tests and allowed the specific identification of dirofilaria immitis, toxocara canis, angiostrongylus cantonensis and ascaris lumbricoides in animals sensitized with parasite antigens, and the diagnosis of natural (d. immitis, t. canis and angiostrongylus cantonensis) and zoonotic nematode infections. lymphocytes remained viable in who ...	1981	6168047
host-parasite relationship of angiostrongylus cantonensis. 2. angiotropic behaviour and abnormal site development.	migratory young fifth-stage angiostrongylus cantonensis transplanted intracranially into recipient rats were found to reach the lungs 3-4 days later by randomly entering cerebral veins. however, worms which were transplanted close to extracranial veins such as the jugular and femoral veins, or into the pleural and peritoneal cavities failed to enter these blood vessels. third-stage larvae were capable of infecting rats via skin wounds. protease activity was not detected around young fifth and th ...	1981	7210820
[finding of angiostrongylus cantonensis in the cerebrospinal fluid of a boy with eosinophilic meningoencephalitis].		1981	7034073
[angiostrongylus cantonensis. intermediate hosts in the 2 havana provinces].		1981	7038791
[bradybaena similaris (ferussac): intermediate host of angiostrongylus cantonensis in cuba].		1981	7038796
elisa for the detection of angiostrongylus cantonensis antibodies in patients with eosinophilic meningitis.	the enzyme-linked immunosorbent assay (elisa) was used to examine sera from twelve taiwanese children with eosinophilic meningitis suspected to be induced by infection with angiostrongylus cantonensis. polystyrene tubes were coated with angiostrongylus cantonensis antigens (5 micrograms/ml protein) prepared from fourth-stage larvae recovered from the brains of experimentally infected rats. alkaline phosphatase labelled goat antihuman igg conjugate was used in a dilution of 1 to 500; sera were di ...	1982	7051339
experimental light infection of angiostrongylus cantonensis in rats.	an experimental infection with a smaller number of angiostrongylus cantonensis, using rats as hosts, was carried out. when the rats were infected with one and two larvae of a. cantonensis, the infection rates were 45.5% and 73.3% and recovery rates of the adult worms were 45.5% and 66.7%, respectively. in cases when more than three larvae were given to rats, all rats were found to be infected and recovery rates were around 70%, which is the same as in the case of infection with many larvae. the ...	1982	7086927
eosinophilic meningitis and hydrocephalus in an infant.	central nervous system invasion by helminths is the most frequent cause of eosinophilic pleocytosis in the csf. although csf eosinophilia is an unusual finding in the continental united states, it is not an uncommon observation in cases of meningitis in hawaii and the south pacific. the rat lungworm, angiostrongylus cantonensis has been implicated as the causal agent responsible for cases of eosinophilic meningitis in these areas. the diagnosis of eosinophilic meningitis secondary to a cantonens ...	1982	7092618
[eosinophil response in albino rats to infection with angiostrongylus cantonensis (author's transl)].	five male wistar rats (200 grams each) were infected with 100 third stage larvae of angiostrongylus cantonensis by gastric intubation. after 42 days of infection, a large number of first stage larvae was found in the feces of all infected rats. blood examination revealed that the number of eosinophil increased substantially, when compared to controls, at 6, 36, and 46 days after infection. the percentages of eosinophils in blood obtained at day 6, 36, and 46 was about 4 to 6-fold of control grou ...	1982	7094683
angiostrongylus cantonensis: biogenic amines in the lungs of infected rats.		1982	7095071
glycolytic enzymes in juvenile and adult angiostrongylus cantonensis.	in extracts of adult angiostrongylus cantonensis, the activities of enzymes including glucokinase, phosphoglucoisomerase, phosphofructokinase, aldolase, triosepho sphate isomerase, glyceraldehydephosphate dehydrogenase, phosphoglycerokinase, phosphoglyceromutase, enolase, pyruvate kinase, lactate dehydrogenase, pyruvate decarboxylase, alcohol dehydrogenase, glucose 6-phosphate dehydrogenase, glycerophosphate dehydrogenase and pyruvate dehydrogenase complex were demonstrated. the present of signi ...	1982	7112211
studies on chemotherapy of parasitic helminths (vii). effects of various cholinergic agents on the motility of angiostrongylus cantonensis.	effects of various cholinergic agents on the motility of angiostrongylus cantonensis were studied to define the neuropharmacological properties of this worm. stimulation of the motility and/or contraction were shown by eserine, ach, carbachol, nicotine, dmpp, pyrantel, and ba2+, but not by pilocarpine and mcn-a-343. contraction was similarly observed by these agents in the preparations paralyzed with praziquantel. paralysis was caused remarkably by d-tubocurarine and slightly by succinylcholine, ...	1982	7131950
antibody responses in rats infected with angiostrongylus cantonensis and the passive transfer of protective immunity with immune serum.	little haemagglutinating antibody was detected in the serum of rats with primary angiostrongylus cantonensis infections until the juvenile worms left the brain and lodged in the lungs about 35 days after infection. antibody titres reached a peak 50 days after infection and were maintained for at least a further 95 days. increasing the infective dose of a. cantonensis larvae increased the peak antibody titres attained by the infected rats. re-infection temporarily reduced the serum antibody titre ...	1982	7136191
passive immunity in rats infected with angiostrongylus cantonensis: interactions between syngeneic immune serum and sensitized lymph node cells.	immune serum injected into the peritoneum of rats passively protected them against angiostrongylus cantonensis; this protection was greater than that conferred by passively transferred immune lymph node cells. when immune lymph node cells and serum were transferred together into the same rat, no enhanced protection was observed. the protective effect of serum was inhibited by the lymph node cells to levels commensurate with those conferred by immune lymph node cells alone. normal lymph node cell ...	1982	7136196
population dynamics of angiostrongylus cantonensis during primary infections in rats.	about 35% of angiostrongylus cantonensis larvae became patent adults irrespective of the dose used to establish primary infections in laboratory rats. worm growth and fecundity was depressed in infections from high compared with low doses of infective larvae. rats infected with up to 50 a. cantonensis larvae survived infection better than rats given greater numbers of larvae. the biology of a. cantonensis surviving in laboratory rats from single infections with 50 larvae for over a year was stud ...	1982	7145479
the biology of angiostrongylus cantonensis larvae in immune rats.	rats acquired protective immunity to angiostrongylus cantonensis after a single infection with 50 infective larvae. immunity was stronger after subsequent infections. fewer worms were recovered which were shorter and produced fewer progeny after secondary and tertiary infections. however, the growth of a. cantonensis during the early developmental stages in the brain and the ability of the young adult parasites to migrate to the lungs was not affected in the immune host.	1982	7147005
eosinophilic radiculomyeloencephalitis: an angiostrongyliasis outbreak in american samoa related to ingestion of achatina fulica snails.	for the first time in american samoa an outbreak of eosinophilic radiculomyeloencephalitis was related to eating giant african snails (achatina fulica) infected with angiostrongylus cantonensis. among 24 korean fisherman sharing the same infective meal, 16 who ate raw or partially cooked snails became ill; five who ate boiled snails and three who ate none remained well. the ensuing illnesses began within 1-6 days, persisted up to 10 weeks, and were characterized by both peripheral blood and spin ...	1982	7149098
prevalence of angiostrongylus cantonensis infection in commensal rats in bombay.		1982	7166636
[angiostrongylus cantonensis in madagascar].		1982	7186336
[studies on chemotherapy of parasitic helminths (iv). effects of alkaloids from sophora flavescens on the motility of parasitic helminths and isolated host tissues (author's transl)].	effects of n-methylcytisine (n-mc) and matrine (mat), alkaloids from sophora flavescens on the motility of parasitic helminths and isolated frog rectus and mouse ileum were studied. 1) the motility of angiostrongylus cantonensis was affected spastically by n-mc (1.2 x 10(-6) approximately 1.2 x 10(-4) m), but paralytically by mat (10(-5) approximately 10(-4) m). 2) the motility of dipylidium caninum and fasciola hepatica was affected paralytically by n-mc (1.2 x 10(-4) approximately 1.2 x 10(-3) ...	1982	7200047
[studies on chemotherapy of parasitic helminths (iii). effects of tuberostemonine from stemona japonica on the motility of parasitic helminths and isolated host tissues (author's transl)].	effects of tuberostemonine (ts), an alkaloid from stemona japonica, on the motility of parasitic helminths and isolated frog rectus and mouse ileum were studied. 1) ts (6.7 x 10(-6) approximately 2 x 10(-5) m) paralyzed the motility of angiostrongylus cantonensis. 2) ts (6.7 x 10(-5) m) showed contractive effects on the motility of dipylidium caninum and fasciola hepatica. 3) treatment with ts (6.7 x 10(-5) approximately 4.8 x 10(-4) m) had little effect on the motility of schistosoma japonicum. ...	1982	7200048
studies on chemotherapy of parasitic helminths (viii). effects of some possible neurotransmitters on the motility of angiostrongylus cantonensis.	effects of some possible neurotransmitters such as gaba, adrenergic drugs, and 5-ht and their antagonists on the motility of angiostrongylus cantonensis were studied. paralysis was caused by gaba, avermectin bia (av-bia), piperazine and alpha-adrenergic agonists such as adrenaline, noradrenaline, phenylephrine, clonidine and methoxamine, but not by beta-adrenergic agonists such as isoproterenol. the paralysis by gaba or av-bia was antagonized by gaba antagonists such as picrotoxin and/or bicucul ...	1982	6127426
a probable case of ocular angiostrongyliasis in new britain, papua new guinea.	unilateral iritis, keratitis and episcleritis presented in a 45-year-old female melanesian from new britain, papua new guinea. a motile nematode was seen in the anterior vitreous but was not recovered. inflammation resolved with topical corticosteroid and antibiotic treatment, but visual impairment persisted. she failed to return for repeat serology after discharge, and measurement of serum antibody levels to angiostrongylus cantonensis in the single specimen obtained, using the direct and indir ...	1982	6926775
the course of angiostrongylus cantonensis infection in athymic nude and neonatally thymectomized mice.	balb/c athymic nude and thymus-reconstituted nude mice and neonatally thymectomized balb/c mice were infected with stage 3 larvae of angiostrongylus cantonensis and the worm burdens of the mice were determined at various times after infection. when the nude and thymectomized mice were exposed to the parasite, some worms were found to migrate from the brain to lungs but died there without reaching maturity. this pulmonary arterial migration of the worms in the nude did not occur following thymic ...	1982	6981266
the role of the spleen in protective immunity against angiostrongylus cantonensis in rats: splenectomy and passive spleen cell transfers.		1983	6853017
immunological regulation of angiostrongylus cantonensis infections in rats: modulation of population density and enhanced parasite growth following one or two superimposed infections.	rats acquired a degree of protective immunity to reinfection with angiostrongylus cantonensis after a single infection with 50 infective larvae. infected rats resisted the establishment of most challenging larvae and protective immunity increased with subsequent reinfections. part of the primary infection was lost after a superimposed second and also following a superimposed third infection, but the total size of the concurrent adult worm populations remained the same as that from a primary infe ...	1983	6875253