Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| [a case of myelitis with eosinophilia of the cerebrospinal fluid]. | a 25-year-old woman developed numbness of the right flank two weeks after a one-month stay in thailand and laos, which are known as areas of angiostrongylosis cantonensis infections. the signs were numbness, pain sense disorder, and vibration sense disorder on the region of the 6th to 12th dermatome. on a mri t(2) weighted image (t(2)wi), signal hyperintensity in a longitudinal spinal lesion was seen. in the cerebrospinal fluid (csf), eosinophils were detected. the patient was diagnosed with eos ... | 2015 | 26165808 |
| effect of different helminth extracts on the development of asthma in mice: the influence of early-life exposure and the role of il-10 response. | it is not currently clear whether different parasites have distinct effects on the airway inflammatory response in asthma and whether exposure in early life to helminths have a stronger impact in a potential inhibitory effect on asthma. the aim of this study is to evaluate the effect of exposure to different helminth extracts on the development of allergic pulmonary response in mice, including early-life exposure. different helminth extracts (angiostrongylus costaricensis, angiostrongylus canton ... | 2015 | 26093162 |
| geographic range expansion for rat lungworm in north america. | using quantitative pcr analysis and dna sequencing, we provide evidence for the presence of rat lungworm (angiostrongylus cantonensis) in oklahoma, usa, and identified a potentially novel rat host (sigmodon hispidus). our results indicate a geographic range expansion for this medically and ecologically relevant parasite in north america. | 2015 | 26079818 |
| preliminary expression profile of cytokines in brain tissue of balb/c mice with angiostrongylus cantonensis infection. | angiostrongylus cantonensis (a. cantonensis) infection can result in increased risk of eosinophilic meningitis. accumulation of eosinophils and inflammation can result in the a. cantonensis infection playing an important role in brain tissue injury during this pathological process. however, underlying mechanisms regarding the transcriptomic responses during brain tissue injury caused by a. cantonensis infection are yet to be elucidated. this study is aimed at identifying some genomic and transcr ... | 2015 | 26070790 |
| canine neural angiostrongylosis: a case-control study in sydney dogs. | to determine the risk factors for canine neural angiostrongylosis in dogs domiciled in sydney, australia; geographic location, age, sex, neuter status, weight and breed were assessed. | 2015 | 26010924 |
| microglia activation: one of the checkpoints in the cns inflammation caused by angiostrongylus cantonensis infection in rodent model. | angiostrongylus cantonensis (a. cantonensis) is a rodent nematode. adult worms of a. cantonensis live in the pulmonary arteries of rats; humans are non-permissive hosts like the mice. the larva cannot develop into an adult worm and only causes serious eosinophilic meningitis or meningo-encephalitis if humans or mice eat food containing larva of a. cantonensis in the third stage. the differing consequences largely depend on differing immune responses of hosts to parasite during a. cantonensis inv ... | 2015 | 26002828 |
| the prevalence of angiostrongylus cantonensis/mackerrasae complex in molluscs from the sydney region. | angiostrongylus cantonensis and angiostrongylus mackerrasae are metastrongyloid nematodes that infect various rat species. terrestrial and aquatic molluscs are intermediate hosts of these worms while humans and dogs are accidental hosts. angiostrongylus cantonensis is the major cause of angiostrongyliasis, a disease characterised by eosinophilic meningitis. although both a. cantonensis and a. mackerrasae are found in australia, a. cantonensis appears to account for most infections in humans and ... | 2015 | 26000568 |
| spread of the rat lungworm (angiostrongylus cantonensis) in giant african land snails (lissachatina fulica) in florida, usa. | the rat lungworm (angiostrongylus cantonensis) is a parasitic nematode that causes rat lungworm disease. it is the leading cause of eosinophilic meningitis and is a zoonotic health risk. we confirmed the presence of a. cantonensis using species-specific, quantitative pcr in 18 of 50 (36%) giant african land snails (lissachatina fulica) collected from miami, florida, us in may 2013. these snails were collected from seven of 21 core areas that the florida department of agriculture and consumer ser ... | 2015 | 25973628 |
| draft genome of neurotropic nematode parasite angiostrongylus cantonensis, causative agent of human eosinophilic meningitis. | angiostrongylus cantonensis is a bursate nematode parasite that causes eosinophilic meningitis (or meningoencephalitis) in humans in many parts of the world. the genomic data from a. cantonensis will form a useful resource for comparative genomic and chemogenomic studies to aid the development of diagnostics and therapeutics. we have sequenced, assembled and annotated the genome of a. cantonensis. the genome size is estimated to be ∼260 mb, with 17,280 genomic scaffolds, 91x coverage, 81.45% for ... | 2015 | 25910624 |
| detection of angiostrongylus cantonensis in the blood and peripheral tissues of wild hawaiian rats (rattus rattus) by a quantitative pcr (qpcr) assay. | the nematode angiostrongylus cantonensis is a rat lungworm, a zoonotic pathogen that causes human eosinophilic meningitis and ocular angiostrongyliasis characteristic of rat lungworm (rlw) disease. definitive diagnosis is made by finding and identifying a. cantonensis larvae in the cerebral spinal fluid or by using a custom immunological or molecular test. this study was conducted to determine if genomic dna from a. cantonensis is detectable by qpcr in the blood or tissues of experimentally infe ... | 2015 | 25910229 |
| release of lungworm larvae from snails in the environment: potential for alternative transmission pathways. | gastropod-borne parasites may cause debilitating clinical conditions in animals and humans following the consumption of infected intermediate or paratenic hosts. however, the ingestion of fresh vegetables contaminated by snail mucus and/or water has also been proposed as a source of the infection for some zoonotic metastrongyloids (e.g., angiostrongylus cantonensis). in the meantime, the feline lungworms aelurostrongylus abstrusus and troglostrongylus brevior are increasingly spreading among cat ... | 2015 | 25884402 |
| a case of ocular angiostrongyliasis with molecular identification of the species in vietnam. | a 23-year-old female residing in a village of cao bang province, north vietnam, visited the hospital of hanoi medical university in july 2013. she felt dim eyes and a bulge-sticking pain in her left eye for some days before visiting the hospital. in the hospital, a clinical examination, an eye endoscopy, and an operation were carried out. a nematode specimen was collected from the eye of this patient. the body of this worm was thin and long and measured 22.0×0.3 mm. it was morphologically sugges ... | 2015 | 26797438 |
| effects of albendazole combined with tsii-a (a chinese herb compound) on optic neuritis caused by angiostrongylus cantonensis in balb/c mice. | angiostrongylus cantonensis (a. cantonensis) infection can lead to optic neuritis, retinal inflammation, damage to ganglion cells, demyelination of optic nerve and visual impairment. combined therapy of albendazole and dexamethasone is a common treatment for the disease in the clinic, but it plays no role in vision recovery. therefore, it has been necessary to explore alternative therapies to treat this disease. previous studies reported the neuro-productive effects of two constituents of danshe ... | 2015 | 26608105 |
| real-time polymerase chain reaction detection of angiostrongylus cantonensis dna in cerebrospinal fluid from patients with eosinophilic meningitis. | angiostrongylus cantonensis is the most common infectious cause of eosinophilic meningitis. timely diagnosis of these infections is difficult, partly because reliable laboratory diagnostic methods are unavailable. the aim of this study was to evaluate the usefulness of a real-time polymerase chain reaction (pcr) assay for the detection of a. cantonensis dna in human cerebrospinal fluid (csf) specimens. a total of 49 csf specimens from 33 patients with eosinophilic meningitis were included: a. ca ... | 2016 | 26526920 |
| levels of infection with the lungworm angiostrongylus cantonensis in terrestrial snails from thailand, with cryptozona siamensis as a new intermediate host. | angiostrongylus cantonensis is primarily considered an emerging infectious agent of eosinophilic meningitis or meningoencephalitis with a worldwide distribution. rodents and snails are important invasive hosts for transmission and expansion of a. cantonensis. the objective of this study was to investigate infection levels of a. cantonensis in snails, the most important natural intermediate host. our study location was mueang kamphaeng phet district, kamphaeng phet province, and was undertaken be ... | 2016 | 26767419 |
| the influence of angiostrongylus cantonensis (nematoda, metastrongylidae) infection on the aerobic metabolism of biomphalaria straminea and biomphalaria tenagophila (mollusca, gastropoda). | angiostrongylus cantonensis is considered the main agent responsible for human eosinophilic meningoencephalitis. this parasite has low specificity for mollusk hosts and it can also use aquatic snails as auxiliary hosts. studies based on the metabolic profile of biomphalaria spp. infected by a. cantonensis have been conducted to observe parasite-host interactions. in the present study, the glucose content in the hemolymph and glycogen content in the digestive gland and cephalopedal mass of biomph ... | 2016 | 27743973 |
| structural and functional characterisation of foxo/acan-daf-16 from the parasitic nematode angiostrongylus cantonensis. | fork head box transcription factors subfamily o (foxo) is regarded to be significant in cell-cycle control, cell differentiation, ageing, stress response, apoptosis, tumour formation and dna damage repair. in the free-living nematode caenorhabditis elegans, the foxo transcription factor is encoded by ce-daf-16, which is negatively regulated by insulin-like signaling (iis) and involved in promoting dauer formation through bringing about its hundreds of downstream genes expression. in nematode par ... | 2016 | 27619188 |
| fecal parasite identification by microscopy and pcr in scimitar-horned oryx, oryx dammah, managed at two sites. | the scimitar-horned oryx, oryx dammah, an endangered species extinct in the wild, is managed in various captive management programs and is the focus of reintroduction efforts. management variability can contribute to substantial parasite load differences, which can affect deworming programs and potentially transfer parasites to different regions with translocations. parasite studies in o. dammah are lacking. in this study, we determined fecal egg/oocyst counts of o. dammah in two captive herds, ... | 2016 | 27942456 |
| angiostrongylus cantonensis in the vector snails pomacea canaliculata and achatina fulica in china: a meta-analysis. | angiostrongyliasis is a food-borne parasitic disease induced by the nematode angiostrongylus cantonensis, and has been recognized as the main cause leading to human eosinophilic meningitis. humans usually acquire infection by digestion of infected pomacea canaliculata and achatina fulica, the most predominant intermediate hosts found in china. this meta-analysis was aimed to assess the prevalence of a. cantonensis infection among these two snails in china in the past 10 years. data were systemat ... | 2016 | 26621284 |
| angiostrongylus cantonensis infection on mayotte island, indian ocean, 2007-2012. | human angiostrongyliasis (ha) is a neurological helminthic disease caused by the lung worm angiostrongylus cantonensis. it is suspected in the combination of travel or a residence in an endemic area and eosinophilic meningitis. in mayotte, an island in the indian ocean, cases are rare but regular. the main objective of our study was to describe the epidemiological and diagnosis clues of ha in mayotte. the secondary objectives were to evaluate the contribution of real-time polymerase chain reacti ... | 2016 | 27144645 |
| a non-travel related case of angiostrongylus cantonensis eosinophilic meningomyelitis acquired in israel. | 2016 | 27772767 | |
| activation of the hypothalamic-pituitary-adrenal (hpa) axis contributes to the immunosuppression of mice infected with angiostrongylus cantonensis. | immunosuppression has been described as a consequence of brain injury and infection by different mechanisms. angiostrongylus cantonensis can cause injury to the central nervous system and eosinophilic meningitis to human. both t cell and b cell immunity play an essential role in the resistance of the infection. however, whether brain injury caused by a. cantonensis infection can lead to immunosuppression is not clear. therefore, the present study sought to observe the alteration of immune respon ... | 2016 | 27733201 |
| angiostrongylus cantonensis infection: a cause of fever of unknown origin in pediatric patients. | fever of unknown origin (fuo) in children is frequently caused by infectious diseases. angiostrongylus cantonensis, while a primary cause of eosinophilic meningitis, is rarely a cause of fuo. we present 2 pediatric cases of fuo caused by angiostrongylus cantonensis acquired in houston, texas, outside its usual geographic distribution. | 2016 | 27578821 |
| evaluation of library preparation methods for illumina next generation sequencing of small amounts of dna from foodborne parasites. | illumina library preparation methods for ultra-low input amounts were compared using genomic dna from two foodborne parasites (angiostrongylus cantonensis and cyclospora cayetanensis) as examples. the ovation ultralow method resulted in libraries with the highest concentration and produced quality sequencing data, even when the input dna was in the picogram range. | 2016 | 27553132 |
| angiostrongylus cantonensis and a. malaysiensis broadly overlap in thailand, lao pdr, cambodia and myanmar: a molecular survey of larvae in land snails. | angiostrongylus cantonensis is a zoonotic nematode parasite causing human eosinophilic meningitis (or meningoencephalitis) worldwide. a closely related species, angiostrongylus malaysiensis, might also be a human pathogen. larvae were obtained from land snails in lao pdr, cambodia, myanmar and thailand. we sequenced two nuclear gene regions (nuclear ribosomal its2 and ssu rrna) and a portion of one mitochondrial gene (coi) from these larvae. angiostrongylus cantonensis and a. malaysiensis were i ... | 2016 | 27513930 |
| development of lateral flow immunoassay for antigen detection in human angiostrongylus cantonensis infection. | angiostrongyliasis is difficult to be diagnosed for the reason that no ideal method can be used. serologic tests require specific equipment and are not always available in poverty-stricken zone and are time-consuming. a lateral flow immunoassay (lfia) may be useful for angiostrongyliasis control. we established a lfia for the diagnosis of angiostrongyliasis based on 2 monoclonal antibodies (mabs) against antigens of angiostrongylus cantonensis adults. the sensitivity and specificity were 91.1% a ... | 2016 | 27417097 |
| cloning and expression of a 16-kda recombinant protein from angiostrongylus cantonensis for use in immunoblot diagnosis of human angiostrongyliasis. | angistrongylus cantonensis is a zoonotic nematode parasite and causative agent of human angiostrongyliasis, which clinically presents as eosinophilic meningitis or meningoencephalitis. diagnosis of the disease is problematic since parasitologic findings are infrequent, and infection determinations must be based on the clinical symptoms and serological tests with limited specificities and sensitivities. the aim of the present study was to identify and generate a novel recombinant protein from a. ... | 2016 | 27406573 |
| phylogeny of angiostrongylus cantonensis in thailand based on cytochrome c oxidase subunit i gene sequence. | angiostrongylus cantonensis is an emerging infectious agent causing eosinophilic meningitis or meningoencephalitis in humans with clinical manifestation of severe headache. molecular genetic studies on classification and phylogeny of a. cantonensis in thailand are limited. this study surveyed a. cantonensis larvae prevalence in natural intermediate hosts across thailand and analyzed their phylogenetic relationships. a total of 14,032 freshwater and land snails were collected from 19 provinces of ... | 2016 | 27405119 |
| an epidemiological study of a. cantonensis in jamaica subsequent to an outbreak of human cases of eosinophilic meningitis in 2000. | the infection status of angiostrongylosis in jamaica was assessed in wild rats and molluscs in the 5 years following the major outbreak of eosinophilic meningitis (em) in 2000. parasitological analyses of 297 rattus rattus and 140 rattus norvegicus, and 777 terrestrial molluscs from all 14 parishes on the island revealed angiostrongylus cantonensis in 32·0% of the rats and in 12·5% of the molluscs. multivariate analyses confirmed that a. cantonensis occurred significantly more frequently in r. r ... | 2016 | 27350332 |
| vectors and spatial patterns of angiostrongylus cantonensis in selected rice-farming villages of muñoz, nueva ecija, philippines. | in the philippines, rats and snails abound in agricultural areas as pests and source of food for some of the local people which poses risks of parasite transmission to humans such as angiostrongylus cantonensis. this study was conducted to determine the extent of a. cantonensis infection among rats and snails collected from rice-farming villages of muñoz, nueva ecija. a total of 209 rats, 781 freshwater snails, and 120 terrestrial snails were collected for the study. heart and lungs of rats and ... | 2016 | 27313865 |
| comparative pathogenesis of eosinophilic meningitis caused by angiostrongylus mackerrasae and angiostrongylus cantonensis in murine and guinea pig models of human infection. | this study investigated comparatively the pathogenicity of experimental infection of mice and guinea pigs, with angiostrongylus mackerrasae and the closely related species a. cantonensis. time course analyses showed that a. mackerrasae causes eosinophilic meningitis in these hosts, which suggests that the species has the potential to cause meningitis in humans and domestic animals. both a. mackerrasae and the genetically similar a. cantonensis caused eosinophilic meningitis in mice at two time p ... | 2016 | 27278827 |
| soluble antigen derived from iv larva of angiostrongylus cantonensis promotes chitinase-like protein 3 (chil3) expression induced by interleukin-13. | angiostrongyliasis caused by angiostrongylus cantonensis (a. cantonensis) is an emerging food-borne parasitic disease, which refers basically to eosinophilic meningitis. chitinase-like protein 3 (chil3), a member of chitinase-like protein family which has chemotactic activity for eosinophils, is reported to be highly upregulated in brain of mouse infected with a. cantonensis. the mechanisms of high expression of chil3 and the association between a. cantonensis and chil3 are rarely reported. in o ... | 2016 | 27256220 |
| withdrawn: alterations in the mitochondrial physiology of biomphalaria glabrata (mollusca: gastropoda) after experimental infection by angiostrongylus cantonensis (nematoda: metastongylidae). | this article has been withdrawn at the request of the author(s) and/or editor. the publisher apologizes for any inconvenience this may cause. the full elsevier policy on article withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. | 2016 | 27240754 |
| angiostrongylus cantonensis: a review of its distribution, molecular biology and clinical significance as a human pathogen. | angiostrongylus cantonensis is a metastrongyloid nematode found widely in the asia-pacific region, and the aetiological agent of angiostrongyliasis; a disease characterized by eosinophilic meningitis. rattus rats are definitive hosts of a. cantonensis, while intermediate hosts include terrestrial and aquatic molluscs. humans are dead-end hosts that usually become infected upon ingestion of infected molluscs. a presumptive diagnosis is often made based on clinical features, a history of mollusc c ... | 2016 | 27225800 |
| pepsin is a positive regulator of ac-cathb-2 involved in the rat gut penetration of angiostrongylus cantonensis. | angiostrongyliasis caused by the rat lungworm, angiostrongylus cantonensis (a. cantonensis), has globally spread from the traditional epidemic areas. the small intestine is the site where the third-stage larvae (l3) of this worm entered the host body, and parasite proteases are involved in this process. ac-cathb-2, a cathepsin b-like cysteine of a. cantonensis, was formerly isolated from the insoluble part of fragmentised escherichia coli without activity. the unplanned low activity of prokaryot ... | 2016 | 27189461 |
| eosinophilic meningitis caused by angiostrongylus cantonensis mimicking embolic stroke. | 2016 | 27185606 | |
| infection by the nematode angiostrongylus cantonensis induces differential expression of mirnas in mouse brain. | the parasitic nematode angiostrongylus cantonensis is the primary pathogen causing eosinophilic meningitis and meningoencephalitis in nonpermissive hosts. the larval parasites are eliminated by the host's immune responses in the central nervous system (cns) through infiltration of eosinophils and lymphocytes. this study aimed to determine primary alterations of microrna (mirna) during a. cantonensis infection in mice. | 2016 | 27156837 |
| characterization of the n-glycans of female angiostrongylus cantonensis worms. | glycoconjugates play a crucial role in the host-parasite relationships of helminthic infections, including angiostrongyliasis. it has previously been shown that the antigenicity of proteins from female angiostrongylus cantonensis worms may depend on their associated glycan moieties. here, an n-glycan profile of a. cantonensis is reported. a total soluble extract (te) was prepared from female a. cantonensis worms and was tested by western blot before and after glycan oxidation or n- and o-glycosi ... | 2016 | 27107931 |
| characterizing longitudinal changes in rabbit brains infected with angiostrongylus cantonensis based on diffusion anisotropy. | angiostrongylus cantonensis has become a global source of infection in recent years, and the differential diagnosis and timely follow-up are crucial in the management of the infection. magnetic resonance imaging (mri) has been suggested as a non-invasive technique in characterizing and localizing lesions during the parasitic infections in the brain. non-invasive diffusion tensor imaging (dti) can be used to distinguish microscopic cerebral structures but cannot resolve the more complicated neura ... | 2016 | 26808581 |
| anti-st2 monoclonal antibody inhibits eosinophil infiltration in angiostrongylus cantonensis-infected mice. | interleukin-33 (il-33) could play an important role in the pathogenesis of angiostrongylosis. however, the role of il-33/st2 pathway in this parasitic infection is uncertain. | 2016 | 24657070 |
| integrating morphology, breeding ground and mitochondrial coi gene analysis for species identification of bellamya lithophaga (gastropoda: viviparidae) in china. | angiostrongylus cantonensis is a zoonotic public health concern that causes human severe eosinophilic meningitis in southeast asia and china. as a medically important intermediate host of a. cantonensis, bellamya lithophaga (gastropoda: viviparidae) is often confused with other morphologically similar sibling species of genus bellamya, such as b. aeruginosa and b. purificata in the past. hence, the aim of the present study was to investigate evidences to discriminate these equivocal bellamya spe ... | 2017 | 25848394 |
| phylogeography of angiostrongylus cantonensis (nematoda: angiostrongylidae) in southern china and some surrounding areas. | angiostrongylus cantonensis is of increasing public health importance as the main zoonotic pathogen causing eosinophilic meningitis or meningoencephalitis, which has been documented all over the world. however, there are very limited studies about its phylogeography and spread pattern. in the present study, the phylogeography of a. cantonensis in southern china (including taiwan) and partial areas of southeast asia were studied based on the sequences of complete mitochondrial cytochrome b (cytb) ... | 2017 | 28827809 |
| angiostrongyliasis (rat lungworm disease): viewpoints from hawai'i island. | hawai'i, particularly east hawai'i island, is the epicenter for angiostrongyliasis in the united states. case numbers have been increasing and appear to parallel the introduction and spread of the semislug (parmarion martensi) to east hawai'i. the infective larvae in rainwater catchment as a source for household and agricultural water may also play a role. the spread of angiostrongylus cantonensis as well as the potential introduction of the semislug p. martensi should be a concern to the mainla ... | 2017 | 28820576 |
| torn from the headlines: angiostrongylus cantonensis (rat lungworm) is established in florida. | 2017 | 28810745 | |
| angiostrongylus cantonensis daf-2 regulates dauer, longevity and stress in caenorhabditis elegans. | the insulin-like signaling (iis) pathway is considered to be significant in regulating fat metabolism, dauer formation, stress response and longevity in caenorhabditis elegans. "dauer hypothesis" indicates that similar iis transduction mechanism regulates dauer development in free-living nematode c. elegans and the development of infective third-stage larvae (il3) in parasitic nematodes, and this is bolstered by a few researches on structures and functions of the homologous genes in the iis path ... | 2017 | 28576337 |
| effects of experimental angiostrongylus cantonensis infection on the reproductive biology of biomphalaria straminea and biomphalaria tenagophila. | eosinophilic meningoencephalitis is an endemic zoonosis in southeast asia and the pacific islands, but in recent years, new cases have been reported in various countries outside these regions, including brazil, where it is considered an emerging disease. in this study, the effect of infection by the nematode angiostrongylus cantonensis, one of the main etiologic agent of this disease, on the reproductive biology of the planorbid snails biomphalaria straminea and b. tenagophila was investigated d ... | 2017 | 28802946 |
| soluble antigens from the neurotropic pathogen angiostrongylus cantonensis directly induce thymus atrophy in a mouse model. | the nematode angiostrongylus cantonensis (a.c.) is a neurotropic pathogen; stage-iii larva invade the human (non-permissive host) central nervous system (cns) to cause eosinophilic meningitis or meningoencephalitis accompanied by immunosuppression. in an a.c.-infectedmouse (another non-permissive host) model, cns damage-associated t cell immune deficiency and severe inflammation were proposed to result from activation of the hypothalamic-pituitary-adrenal (hpa) axis. however, glucocorticoids are ... | 2017 | 28548945 |
| resveratrol relieves angiostrongylus cantonensis - induced meningoencephalitis by activating sirtuin-1. | resveratrol, a natural herbal compound found in high levels in grapes and red wine, is frequently used as activator of sirtuin-1. this study investigated the potential function of sirtuin-1 in regulating angiostrongyliasis meningoencephalitis in resveratrol-treated mice. mice were subjected to meningoencephalitis to study the protective effect of resveratrol against meningoencephalitis and investigate the effects of sirtuin-1 activation on brain. results demonstrated that sirtuin-1 level decreas ... | 2017 | 28545897 |
| geographic distribution of angiostrongylus cantonensis in wild rats (rattus rattus) and terrestrial snails in florida, usa. | the parasitic nematode angiostrongylus cantonensis is a major cause of eosinophilic meningitis in humans, and has been documented in other incidental hosts such as birds, horses, dogs and non-human primates. it is endemic in hawaii, and there have been sporadic reports in the southern continental united states. this parasite uses rats as definitive hosts and snails as intermediate hosts. in this study, we collected potential definitive and intermediate hosts throughout florida to ascertain the g ... | 2017 | 28542310 |
| immunologic evaluation of extracted intestinal proteins from angiostrongylus cantonensis adult worms. | to determine whether intestinal angiostrongylus cantonensis antigens can induce protective immunity in rats, gut antigens prepared from female adults (fagp) and somatic antigens prepared from both male (ma) and female (fa) adult worms were used to immunize rats. | 2017 | 28778593 |
| neuronal apoptosis: pathological basis of behavioral dysfunctions induced by angiostrongylus cantonensis in rodents model. | angiostrongylus cantonensis invades the central nervous system (cns) of humans to induce eosinophilic meningitis and meningoencephalitis and leads to persistent headache, cognitive dysfunction, and ataxic gait. infected mice (nonpermissive host), admittedly, suffer more serious pathological injuries than rats (permissive host). however, the pathological basis of these manifestations is incompletely elucidated. in this study, the behavioral test, histological and immunohistochemical techniques, a ... | 2017 | 28719951 |
| eosinophilic meningitis caused by angiostrongylus cantonensis. | rat lungworm, angiostrongylus cantonensis, is one major cause of human eosinophilic meningitis. this helminth is endemic in southeast asia, pacific islands, and the caribbean and has recently expanded to south america. the infection is characterized by an elevated eosinophil count in cerebrospinal fluid. common symptoms and signs include headache, neck stiffness, paresthesia and nausea/vomiting. the unique history of eating freshwater and land snails or slugs within 2 weeks before onset is helpf ... | 2017 | 28704038 |
| autochthonous case of eosinophilic meningitis caused by angiostrongylus cantonensis, france, 2016. | we report a case of a 54-year-old moroccan woman living in france diagnosed with eosinophilic meningitis caused by angiostrongylus cantonensis. diagnosis was based on clinical symptoms and confirmed by testing of serum and cerebrospinal fluid samples. physicians should consider the risk for a. cantonensis infection outside of endemic areas. | 2017 | 28518042 |
| angiostrongylus cantonensis meningitis and myelitis, texas, usa. | infection with angiostrongylus cantonensis roundworms is endemic in southeast asia and the pacific basin. a. cantonensis meningitis and myelitis occurred in summer 2013 in a child with no history of travel outside of texas, usa. angiostrongyliasis is an emerging neurotropic helminthic disease in texas and warrants increased awareness among healthcare providers. | 2017 | 28518035 |
| study on the tolerance and adaptation of rats to angiostrongylus cantonensis infection. | angiostrongylus cantonensis (a. cantonensis) is the most common infectious agent causing eosinophilic meningitis. as an important food-borne parasitic disease, angiostrongyliasis cantonensis is an emerging infectious disease which brings severe harm to central nerve system of human. rat, one of the few permissive hosts of a. cantonensis known to date, plays an indispensable role in the worm's life cycle. however, the tolerance and adaptation of rat to a. cantonensis infection is rarely understoo ... | 2017 | 28493001 |
| scientometrics of zoonoses transmitted by the giant african snail achatina fulica bowdich, 1822. | the dissemination of the giant african snail achatina fulica in several countries has triggered a great number of studies on the mollusk, including those on zoonoses related to health in humans. the current research is a scientific survey on articles published in four databases, namely, pubmed, bireme, scielo and lilacs. results indicate that brazil has a prominent position in international scientific production on this subject, with focus on angiostrongylus cantonensis occurrences. | 2017 | 28423090 |
| comparative transcriptomic analysis of two important life stages of angiostrongylus cantonensis: fifth-stage larvae and female adults. | the mechanisms involved in the fast growth of angiostrongylus cantonensis from fifth-stage larvae (l5) to female adults and how l5 breaks through the blood-brain barrier in a permissive host remain unclear. in this work, we compared the transcriptomes of these two life stages to identify the main factors involved in the rapid growth and transition to adulthood. rna samples from the two stages were sequenced and assembled de novo. gene ontology and kyoto encyclopedia of genes and genomes pathway ... | 2017 | 28644509 |
| eosinophilic meningoencephalitis associated with rat lungworm (angiostrongylus cantonensis) migration in two nine-banded armadillos (dasypus novemcinctus) and an opossum (didelphis virginiana) in the southeastern united states. | angiostrongylus cantonensis, the rat lungworm, was the cause of neural larval migrans in two nine-banded armadillos (dasypus novemcinctus) and one virginia opossum (didelphis virginiana) from the southeastern united states. histologic findings in all three cases included eosinophilic meningoencephalitis with variable numbers of nematode larvae in the meninges or the neuroparenchyma. in two of the three cases, nematodes were extracted from brain tissue via a "squash prep" method. identification o ... | 2017 | 28626635 |
| angiostrongylus cantonensis: an optimized cultivation of this parasitic nematode under laboratory conditions. | angiostrongylus cantonensis (a. cantonensis), a parasitic nematode, is the important neurotropic pathogen which causes human angiostrongyliasis. it has a complex life-cycle and severe parasite-host interaction in contrast to free-living nematode. establishment of a well-suited life-cycle and in vitro cultivation of a. cantonensis in the laboratory will be one of the key techniques to elucidate the mechanism of parasite-host interaction. however, the low survival and growth rate of worms is still ... | 2017 | 28616635 |
| natural infection of the feline lungworm aelurostrongylus abstrusus in the invasive snail achatina fulica from argentina. | the giant african snail achatina fulica is an invasive mollusk native to africa, the first record in argentina was in puerto iguazú, in northeastern argentina in 2010. recently it was reported in corrientes province. this snail can act as an intermediate host of metastrongyloidea nematodes of importance in public health as: angiostrongylus cantonensis, angiostrongylus costaricensis and angiostrongylus vasorum. taking into account the presence of a. fulica in argentina, the objectives of this stu ... | 2017 | 28215862 |
| anti-apoptotic effects of sonic hedgehog signalling through oxidative stress reduction in astrocytes co-cultured with excretory-secretory products of larval angiostrongylus cantonensis. | angiostrongylus cantonensis, the rat lungworm, is an important aetiologic agent of eosinophilic meningitis and meningoencephalitis in humans. co-culturing astrocytes with soluble antigens of a. cantonensis activated the sonic hedgehog (shh) signalling pathway and inhibited the apoptosis of astrocytes via the activation of bcl-2. this study was conducted to determine the roles of the shh signalling pathway, apoptosis, and oxidative stress in astrocytes after treatment with excretory-secretory pro ... | 2017 | 28169282 |
| prevalence and distribution of angiostrongylus cantonensis (nematoda, angiostrongylidae) in achatina fulica (mollusca, gastropoda) in baixada santista, são paulo, brazil. | angiostrongylus cantonensis is causes eosinophilic meningoencephalitis in humans. worldwide expansion of this nematode is linked to the dispersion of their hosts. this study aimed to determine the prevalence of a. cantonensis infection in achatina fulica in the nine municipalities that make up baixada santista, são paulo, brazil. | 2017 | 28327808 |
| cryptic lineage diversity in the zoonotic pathogen angiostrongylus cantonensis. | delimitation of species is still a necessity among parasitic pathogens especially where morphological characters provide limited discernibility. identification of cryptic lineages (independently evolving lineages that are morphologically similar) is critical as there could be lineage-specific traits that are of epidemiological importance. angiostrongylus cantonensis is a zoonotic pathogen that can cause eosinophilic meningitis in humans. recent reports of single marker sequence divergence hint a ... | 2017 | 27940331 |
| spleen atrophy related immune system changes attributed to infection of angiostrongylus cantonensis in mouse model. | the spleen is one of the most important peripheral immune organs, which is frequently affected in infectious diseases. infectious diseases can induce splenic alterations including splenic atrophy and functional alteration, while splenic atrophy may in turn interferes with recovery of infectious diseases. angiostrongyliasis is an infectious disease by angiostrongylus cantonensis (a. cantonensis), which invade non-permissive hosts, such as humans and mice, to cause severe damage to the central ner ... | 2017 | 27878389 |
| cross-reactivity of the 31 kda antigen of angiostrongylus cantonensis - dealing with the immunodiagnosis of meningoencephalitis. | the primary causative agent of eosinophilic meningoencephalitis (eom) in endemic regions is the nematode angiostrongylus cantonensis. the occurrence of eom was previously restricted to countries in southeast asia and the pacific islands; however, more recently, it has been reported from other regions, including brazil. the commonly used diagnosis is detection of specific antibody reactivity to the 31 kda antigen, which is derived from female worm somatic extracts. here we report the occurrence o ... | 2017 | 27866477 |
| cytochrome c oxidase subunit i haplotype diversity of angiostrongylus cantonensis (nematoda: angiostrongylidae). | the rat lungworm angiostrongylus cantonensis is a food-borne zoonotic parasite of public health importance worldwide. it is the primary etiologic agent of eosinophilic meningitis and eosinophilic meningoencephalitis in humans in many countries. it is highly endemic in thailand especially in the northeast region. in this study, a. cantonensis adult worms recovered from the lungs of wild rats in different geographical regions/provinces in thailand were used to determine their haplotype by means of ... | 2017 | 28347653 |
| cytochrome c oxidase subunit i haplotype reveals high genetic diversity of angiostrongylus malaysiensis (nematoda: angiostrongylidae). | the rat lungworm angiostrongylus malaysiensis is a metastrongyloid nematode parasite. it has been reported in malaysia, thailand, laos, myanmar, indonesia and japan. in this study, a. malaysiensis adult worms recovered from the lungs of wild rats in different geographical regions/provinces in thailand were used to determine their haplotype by means of the mitochondrial partial cytochrome c oxidase subunit i (coi) gene sequence. the results revealed high coi haplotype diversity of a. malaysiensis ... | 2017 | 28330511 |
| anti-n-methyl-d-aspartate receptor encephalitis associated with intracranial angiostrongylus cantonensis infection: a case report. | anti-n-methyl-d-aspartate (nmda) receptor encephalitis is a recently described paraneoplastic syndrome with prominent neuropsychiatric symptoms. many of these cases are associated with neoplasma especially teratoma. in addition, a few of cases with anti-nmdar antibodies triggered by viral infection have been reported, but never by parasitic infection. here, we report a novel case of nmda receptor encephalitis in a 51-year-old male related to the development of anti-nmdar antibodies triggered by ... | 2017 | 27778112 |
| angiostrongylus cantonensis is an important cause of eosinophilic meningitis in southern vietnam. | 2017 | 28158507 | |
| first evidence of angiostrongyliasis caused by angiostrongylus cantonensis in guadeloupe, lesser antilles. | infection by the rat lungworm angiostrongylus cantonensis represents the most common cause of infectious eosinophilic meningitis in humans, causing central nervous system (cns) angiostrongyliasis. most of cns angiostrongyliasis cases were described in asia, pacific basin, australia, and some limited parts of africa and america. cns angiostrongyliasis has been reported in the caribbean but never in the lesser antilles. the primary objectives of this study were to depict the first case of cns angi ... | 2017 | 28070007 |
| larval development of angiostrongylus chabaudi, the causative agent of feline angiostrongylosis, in the snail cornu aspersum. | nematodes of the angiostrongylidae family, such as angiostrongylus vasorum and angiostrongylus cantonensis, may cause potentially life-threatening diseases in several mammal species. alongside these well-known species, angiostrongylus chabaudi has been recently found affecting the cardiopulmonary system of domestic and wild cats from italy, germany, greece, romania and bulgaria. nonetheless, significant gaps in the understanding of a. chabaudi epidemiology include the lack of information of spec ... | 2017 | 28805181 |